This is Muscle, skeletal receptor tyrosine protein kinase protein, from Rat, contains 868 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:23326516), Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May positively regulate Rho family GTPases through FNTA, Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation


This is ADP-ribosylation factor GTPase-activating protein 1 protein, from Rat, contains 415 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1), Involved in membrane trafficking and /or vesicle transport, Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment, Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2, Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated, Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine


This is RanBP-type and C3HC4-type zinc finger-containing protein 1 protein, from Rat, contains 508 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (By similarity), Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (By similarity), Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:18303026), Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity), LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity), Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity), LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (By similarity), The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity), LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity), The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity), Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity), Binds polyubiquitin of different linkage types (By similarity)


This is Estrogen receptor beta protein, from Rat, contains 530 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is A-kinase anchor protein 8 protein, from Rat, contains 687 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:8125992), Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis, Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring, May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression, Required for cell cycle G2/M transition and histone deacetylation during mitosis, In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L, Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation, May be involved in regulation of DNA replication by acting as scaffold for MCM2, Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation, In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation, May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells, May act as a carrier protein of GJA1 for its transport to the nucleus, May play a repressive role in the regulation of rDNA transcription, Preferentially binds GC-rich DNA in vitro, In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions, Involved in modulation of Toll-like receptor signaling, Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity)


This is Low affinity immunoglobulin gamma Fc region receptor II protein, from Rat, contains 285 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Binds to the Fc region of immunoglobulins gamma, Low affinity receptor, By binding to IgG it initiates cellular responses against pathogens and soluble antigens


This is Myelin-oligodendrocyte glycoprotein protein, from Rat, contains 245 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Mediates homophilic cell-cell adhesion (By similarity), Minor component of the myelin sheath, May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is E3 ubiquitin-protein ligase Praja-2 protein, from Rat, contains 707 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Has E2-dependent E3 ubiquitin-protein ligase activity, Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation, Essential for PKA-mediated long-term memory processes (PubMed:21423175), Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype, Plays a role in ciliogenesis by ubiquitinating OFD1 (By similarity)


This is Transcription factor COE1 protein, from Rat, contains 584 amino acids, has 1 C5-type Zinc finger.

Key pioneer transcription factor of B-cell specification and commitment, Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3', Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates, For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage, In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold


This is Progesterone receptor protein, from Rat, contains 923 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator of several progesteron-dependent promoters in a variety of cell types, Involved in activation of SRC-dependent MAPK signaling on hormone stimulation


This is Antigen-presenting glycoprotein CD1d protein, from Rat, contains 336 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells


This is Advanced glycosylation end product-specific receptor protein, from Rat, contains 402 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed:19910580, PubMed:28627626), Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes, These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses, Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B, Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (By similarity), Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity), Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons, ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space, Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability, Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome, Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (By similarity)


This is Nuclear receptor subfamily 1 group D member 1 protein, from Rat, contains 615 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1, Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis, Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis, Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG, Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells, Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1, Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway, Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep, In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function, In addition to its activity as a repressor, can also act as a transcriptional activator (By similarity), In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis (PubMed:22425774), In collaboration with SP1, activates GJA1 transcription in a heme-independent manner (By similarity), Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity), Represses the transcription of CES2 (By similarity), Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity), Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity), Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity), Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity), Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Nuclear receptor subfamily 1 group D member 2 protein, from Rat, contains 578 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK, Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1, Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN, Regulates hepatic lipid metabolism via the repression of APOC3, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), In addition to its activity as a repressor, can also act as a transcriptional activator, Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity), Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity), Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity), May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity)


This is Semaphorin-3A protein, from Rat, contains 772 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts, Binds to neuropilin, Involved in the development of the olfactory system and in neuronal control of puberty (By similarity)


This is BDNF/NT-3 growth factors receptor protein, from Rat, contains 821 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation, Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions, May also play a role in neutrophin-dependent calcium signaling in glial cells

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is Interleukin-1 receptor accessory protein protein, from Rat, contains 570 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity), Coreceptor with IL1R1 in the IL-1 signaling system, Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways, Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits, Recruits TOLLIP to the signaling complex, Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex, The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor, Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity), Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity), May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity)

Belongs to the interleukin-1 receptor family


This is Transcription elongation factor A protein 2 protein, from Rat, contains 299 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus


This is Myeloid cell surface antigen CD33 protein, from Mouse, contains 403 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity), Preferentially binds sialic acid to the short O-linked glycans of certain mucins (PubMed:12773563)

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is Insulinoma-associated protein 1 protein, from Mouse, contains 521 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 4 C2H2-type Zinc finger.

C2H2-type 1; atypical

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development, Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters, Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner, Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway, Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases, Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism, Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (By similarity), Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex, Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system, Promotes cell cycle signaling arrest and inhibition of cellular proliferation


This is PAN2-PAN3 deadenylation complex subunit Pan3 protein, from Mouse, contains 837 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP), PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins

Belongs to the protein kinase superfamily, PAN3 family


This is Nuclear receptor subfamily 2 group E member 1 protein, from Mouse, contains 385 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity), Regulates cell cycle progression in neural stem cells of rhe developing brain, Involved in the regulation of retinal development and essential for vision, During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity, May be involved in retinoic acid receptor (RAR) regulation in retinal cells

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Semaphorin-4C protein, from Mouse, contains 834 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling, PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248', Required for normal brain development, axon guidance and cell migration, Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade


This is E3 ubiquitin-protein ligase RNF12-A protein, from African clawed frog, contains 622 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner, Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the formation of a ldb1-lhx1/lim1 complex, Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1


This is Splicing factor 1 protein, from Mouse, contains 653 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Necessary for the ATP-dependent first step of spliceosome assembly, Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA, May act as transcription repressor (By similarity)


This is Nuclear receptor subfamily 6 group A member 1 protein, from Mouse, contains 495 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds to a response element containing the sequence 5'-TCAAGGTCA-3', May be involved in the regulation of gene expression in germ cell development during gametogenesis

Belongs to the nuclear hormone receptor family, NR6 subfamily


This is DNA repair protein complementing XP-A cells homolog protein, from Mouse, contains 272 amino acids, has 1  Zinc finger.

Involved in DNA excision repair, Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region, Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity)


This is Leukocyte immunoglobulin-like receptor subfamily B member 4A protein, from Mouse, contains 335 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931), Receptor for FN1 (PubMed:34089617), Receptor for integrin ITGAV/ITGB3 (PubMed:11323698), Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:8855262, PubMed:10026201, PubMed:11457897, PubMed:11323698), Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301), Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931), Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239), Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399), Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414), Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953), Inhibits lysis by natural killer cells (PubMed:8977169)


This is Zinc finger and BTB domain-containing protein 7B protein, from Mouse, contains 544 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors, Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner (PubMed:15729333, PubMed:29420538), Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment, Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively, Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision (PubMed:15729333, PubMed:24880459, PubMed:18258917, PubMed:23481257), Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling, induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate (PubMed:24880459), During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci (PubMed:22730529), Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells (PubMed:23105140), Also functions as an important metabolic regulator in the lactating mammary glands, Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (PubMed:29420538), Transcriptional repressor of the collagen COL1A1 and COL1A2 genes, May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:7937772), Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation (PubMed:28784777), Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (PubMed:28784777)


This is Sequestosome-1 protein, from Mouse, contains 442 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Autophagy receptor required for selective macroautophagy (aggrephagy) (By similarity), Functions as a bridge between polyubiquitinated cargo and autophagosomes (By similarity), Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (By similarity), Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity), Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (By similarity), Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (By similarity), May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (By similarity), May play a role in titin/TTN downstream signaling in muscle cells (By similarity), May regulate signaling cascades through ubiquitination (By similarity), Adapter that mediates the interaction between TRAF6 and CYLD (PubMed:14960283, PubMed:18382763), May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels (By similarity), Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity), Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity), Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20421418, PubMed:20173742, PubMed:24011591), Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (By similarity)


This is Interleukin-11 receptor subunit alpha-1 protein, from Mouse, contains 432 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity, The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Protein kinase C eta type protein, from Rat, contains 683 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells, In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation, Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes, In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation, In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement, Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs, In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation, Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1, Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation, In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis, Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria, Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 protein, from Mouse, contains 428 amino acids, has 2 C3H1-type Zinc finger.

Plays a role in splicing of the U12-type introns (PubMed:29617656), Implicated also in removal of U2 introns positioned adjacent to a U12 intron (PubMed:29617656)


This is Zinc finger protein ehn-3 protein, from Caenorhabditis elegans, contains 262 amino acids, has 6 C2H2-type Zinc finger.

Required for proper gonadal primordium assembly and somatic gonad precursor cell morphology

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase RNF13 protein, from Rat, contains 380 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that regulates cell proliferation, Involved in apoptosis regulation, Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA, Also involved in protein trafficking and localization


This is Calcium-binding and coiled-coil domain-containing protein 1 protein, from Rat, contains 691 amino acids, has 1 UBZ1-type Zinc finger.

Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG), Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth (By similarity)


This is Transcription factor E4F1 protein, from Human, contains 784 amino acids, has 7 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 3; degenerate

C2H2-type 9; degenerate

Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes


This is E3 ubiquitin-protein ligase ORTHRUS 5 protein, from Mouse-ear cress, contains 623 amino acids, has 1 PHD-type Zinc finger, has 2 RING-type Zinc finger.

PHD-type

RING-type

RING-type

E3 ubiquitin-protein ligase, Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing, Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11


This is E3 SUMO-protein ligase SIZ1 protein, from Mouse-ear cress, contains 884 amino acids, has 1 PHD-type Zinc finger, has 1 SP-RING-type Zinc finger.

PHD-type

SP-RING-type

E3 SUMO protein ligase involved in regulation processes, Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses (PubMed:15894620), Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling, Probably not involved in jasmonic acid (JA)-mediated defense response, Participates in abiotic stress-induced sumoylation, Controls heat shock-induced SUMO1 and SUMO2 conjugation and facilitates basal thermotolerance, Involved in freezing tolerance by mediating sumoylation of ICE1, a transcription activator of the cold signaling regulator CBF3/DREB1A, Acts as positive regulator of drought stress tolerance, Acts as floral repressor that promotes FLC expression by repressing FLD activity through sumoylation, Acts as negative regulator of abscisic acid (ABA) signaling through ABI5 sumoylation, Mediates sumoylation of SCE1, GTE3 and GTE5, Functions as negative regulator of SnRK1 signaling through sumoylation of several components of the SnRK1 complex (PubMed:26662259)


This is E3 ubiquitin-protein ligase ORTHRUS-LIKE 1 protein, from Mouse-ear cress, contains 465 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, May participate in methylation-dependent transcriptional regulation, Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11


This is Natural cytotoxicity triggering receptor 3 ligand 1 protein, from Human, contains 454 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Triggers NCR3-dependent natural killer cell activation


This is E3 ubiquitin-protein ligase RNF43 protein, from Human, contains 783 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled, Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187), Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity)


This is Zinc finger protein 57 protein, from Human, contains 555 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

May be involved in transcriptional regulation


This is ARF GTPase-activating protein GIT1 protein, from Mouse, contains 770 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1, Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity), Through PAK1 activation, positively regulates microtubule nucleation during interphase, Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (By similarity), May promote cell motility both by regulating focal complex dynamics and by the activation of RAC1 (By similarity), May act as scaffold for MAPK1/3 signal transduction, recruiting MAPK1/3 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (By similarity), Plays a role in brain development and function (PubMed:25792865, PubMed:33010377), Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (PubMed:20043896, PubMed:29554125), Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502), In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane, These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502), May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity), In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity), In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (By similarity), May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (PubMed:21499268), Required for successful bone regeneration during fracture healing (PubMed:25138700, PubMed:24586541, PubMed:32460388), The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (PubMed:32460388), May play a role in angiogenesis during fracture healing (PubMed:24586541, PubMed:31502302), In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (By similarity), Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721)


This is Zinc finger C4H2 domain-containing protein protein, from Mouse, contains 224 amino acids, has 1 C4H2-type Zinc finger.

Plays a role in interneurons differentiation, Involved in neuronal development and in neuromuscular junction formation


This is Junctional adhesion molecule C protein, from Rat, contains 310 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis

Belongs to the immunoglobulin superfamily


This is DNA-(apurinic or apyrimidinic site) endonuclease 2 protein, from Mouse, contains 516 amino acids, has 1 GRF-type Zinc finger.

GRF-type

Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (By similarity), Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (By similarity), Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities, Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (By similarity), Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents, In the nucleus functions in the PCNA-dependent BER pathway (By similarity), Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (By similarity), Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (PubMed:18025127, PubMed:19556307), Required for proper cell cycle progression during proliferation of peripheral lymphocytes (PubMed:15319281)

Belongs to the DNA repair enzymes AP/ExoA family


This is Fc receptor-like protein 5 protein, from Mouse, contains 596 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Polycomb group protein EMF2B protein, from Rice, contains 604 amino acids, has 1 C2H2-type Zinc finger.

Polycomb group (PcG) protein, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, They act via the methylation of histones, rendering chromatin heritably changed in its expressibility (Probable), Polycomb group (PcG) protein involved in the repression of flowering under long day (LD) conditions, Regulates floret development (PubMed:19825651)

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is RNA-binding protein MEX3B protein, from Mouse, contains 601 amino acids, has 1 RING-type Zinc finger.

RING-type

RNA-binding protein, May be involved in post-transcriptional regulatory mechanisms (By similarity)


This is N-acetyltransferase ESCO1 protein, from Mouse, contains 843 amino acids, has 1 CCHH-type Zinc finger.

CCHH-type

Acetyltransferase required for the establishment of sister chromatid cohesion, Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together, In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase, Acts by mediating the acetylation of cohesin component SMC3

Belongs to the acetyltransferase family, ECO subfamily


This is E3 ubiquitin-protein ligase SH3RF1 protein, from Mouse, contains 892 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity, In the absence of an external substrate, it can catalyze self-ubiquitination, Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis (By similarity), Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway, Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation, Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells (PubMed:23963642, PubMed:27084103, PubMed:9482736), Plays a crucial role in the migration of neocortical neurons in the developing brain, Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (PubMed:22959435)


This is Izumo sperm-egg fusion protein 1 protein, from Rat, contains 383 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg, The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion, The ligand-receptor interaction probably does not act as a membrane 'fusogen'


This is Protein odd-skipped-related 2 protein, from Rat, contains 276 amino acids, has 3 C2H2-type Zinc finger.

Belongs to the Odd C2H2-type zinc-finger protein family


This is Transcriptional adapter 2-alpha protein, from Rat, contains 443 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4, Required for the function of some acidic activation domains, which activate transcription from a distant site, Binds double-stranded DNA, Binds dinucleosomes, probably at the linker region between neighboring nucleosomes, Plays a role in chromatin remodeling, May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity, May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage


This is E3 ubiquitin-protein ligase RNF34 protein, from Rat, contains 381 amino acids, has 1 FYVE-type Zinc finger, has 1 RING-type Zinc finger.

FYVE-type

RING-type

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins, Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis, May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway, Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation, Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN, Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells, Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation


This is Cell adhesion molecule 1 protein, from Rat, contains 476 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner, Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (By similarity), In mast cells, may mediate attachment to and promote communication with nerves (By similarity), CADM1, together with MITF, is essential for development and survival of mast cells in vivo, By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node, Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells, Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells, Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly, May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons, May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity)


This is E3 SUMO-protein ligase PIAS2 protein, from Rat, contains 572 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway, The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied, However, it seems to be mostly involved in gene silencing, Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity (By similarity), Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity)


This is E3 ubiquitin-protein ligase TRIM68 protein, from Human, contains 485 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Functions as a ubiquitin E3 ligase, Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity


This is Fc receptor-like B protein, from Human, contains 426 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is Histone acetyltransferase ESA1 protein, from Yeast, contains 521 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


This is Histone acetyltransferase ESA1 protein, from Yeast, contains 469 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate


This is Histone acetyltransferase ESA1 protein, from Yeast, contains 439 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate


This is E3 ubiquitin-protein ligase APD2 protein, from Mouse-ear cress, contains 444 amino acids, has 1 RING-type Zinc finger.

RING-type

Exhibits E2-dependent E3 ligase activity (PubMed:22897245), Involved in pollen mitosis II (PMII) regulation during male gametogenesis (PubMed:22897245)


This is SH3 and cysteine-rich domain-containing protein 3 protein, from Zebrafish, contains 334 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization (PubMed:23736855), Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction, Probably functions via its effects on muscle calcium channels, Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane, Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity)


This is DNA-(apurinic or apyrimidinic site) endonuclease 2 protein, from African clawed frog, contains 517 amino acids, has 1 GRF-type Zinc finger.

GRF-type

Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:23754435, PubMed:29361157, PubMed:28028224, PubMed:32516598), Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (PubMed:28028224, PubMed:32516598), Exhibits 3'-5' exonuclease activity on a 3' DNA substrate; nuclease activity is stimulated by interaction with pcna (PubMed:28028224, PubMed:32516598), Has a preference for the 3' recessed ends over blunt-ended substrates, in both the presence and the absence of pcna (PubMed:28028224), Generates single-stranded DNA (ssDNA) via 3'-5' single-strand break (SSB) end resection, thereby promoting a DNA damage response via replication protein A (rpa2)-binding to ssDNA and the recruitment of a checkpoint protein complex, including atr, atr-interacting protein atrip, and rad9, to damage sites following oxidative stress (PubMed:23754435, PubMed:29361157, PubMed:28028224), Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598), Required for chek1 phosphorylation induced by hydrogen peroxide but not by stalled replication forks (PubMed:23754435)


This is Endoplasmic reticulum junction formation protein lunapark protein, from African clawed frog, contains 440 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology, Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:27619977), May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network (By similarity)


This is Zinc finger protein PLAG1 protein, from Human, contains 500 amino acids, has 7 C2H2-type Zinc finger.

Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed, Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction, Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas, Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood, Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia


This is Fc receptor-like protein 6 protein, from Human, contains 434 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Acts as a MHC class II receptor (PubMed:20519654), When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291), Does not act as an Fc receptor (PubMed:18991291)


This is Pro-neuregulin-1, membrane-bound isoform protein, from Mouse, contains 645 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors, Perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart, Binds to ERBB4 and ERBB3, Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4, Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity), Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity)


This is BTB/POZ and TAZ domain-containing protein 5 protein, from Mouse-ear cress, contains 368 amino acids, has 1 TAZ-type Zinc finger.

TAZ-type

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins


This is AN1-type zinc finger protein 6 protein, from Human, contains 208 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger.

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis, Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1, Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6, In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)


This is Histone acetyltransferase ESA1 protein, from Yeast, contains 446 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate


This is E3 ubiquitin-protein ligase RMND5A protein, from African clawed frog, contains 391 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

E3 ubiquitin-protein ligase component of the CTLH complex


This is Histone-lysine N-trimethyltransferase SMYD5 protein, from Human, contains 418 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity), In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity), Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (By similarity), Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity), Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28951459)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is XIAP-associated factor 1 protein, from Human, contains 301 amino acids, has 1 TRAF-type Zinc finger.

TRAF-type

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family, Inhibits anti-caspase activity of BIRC4, Induces cleavage and inactivation of BIRC4 independent of caspase activation, Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells, May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway, After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria, Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm, The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4, Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL, May be a tumor suppressor by mediating apoptosis resistance of cancer cells


This is OTU domain-containing protein 7B protein, from Human, contains 843 amino acids, has 1 A20-type Zinc finger.

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses, In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B, Negatively regulates mucosal immunity against infections (By similarity), Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241), Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity), Mediates deubiquitination of EGFR (PubMed:22179831), Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584), Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584), Hydrolyzes both linear and branched forms of polyubiquitin


This is Leukocyte-associated immunoglobulin-like receptor 1 protein, from Human, contains 287 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells, Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11, It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation, May also play its inhibitory role independently of SH2-containing phosphatases, Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta, Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion, Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells, Inhibits the differentiation of peripheral blood precursors towards dendritic cells


This is Single Ig IL-1-related receptor protein, from Human, contains 410 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways, Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4, Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP


This is Endonuclease 8-like 2 protein, from Bovine, contains 329 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles), Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is Protein Jade-1 protein, from Human, contains 842 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767), Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767), May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158), Promotes apoptosis (PubMed:16046545), May act as a renal tumor suppressor (PubMed:16046545), Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112)


This is U11/U12 small nuclear ribonucleoprotein 48 kDa protein protein, from Human, contains 339 amino acids, has 1 CHHC U11-48K-type Zinc finger.

CHHC U11-48K-type

Likely involved in U12-type 5' splice site recognition


This is E3 ubiquitin-protein ligase NHLRC1 protein, from Rat, contains 396 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways, In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS), Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation, Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation, Also promotes proteasome-independent protein degradation through the macroautophagy pathway


This is E3 ubiquitin-protein ligase rnf168 protein, from African clawed frog, contains 557 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage, Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination, Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates, This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of tp53bp1 and brca1, Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)


This is Zinc finger protein 219 protein, from Mouse, contains 726 amino acids, has 9 C2H2-type Zinc finger.

Transcriptional regulator (PubMed:20940257), Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:20940257), Binds to the HMGN1 promoter and may repress HMGN1 expression (By similarity), Regulates SNCA expression in primary cortical neurons (By similarity), Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (PubMed:20940257), Plays a role in chondrocyte differentiation (PubMed:20940257)


This is Zinc finger CW-type PWWP domain protein 1 protein, from Mouse, contains 630 amino acids, has 1 CW-type Zinc finger.

CW-type

Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) that facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (PubMed:32374261, PubMed:32352380, PubMed:32744506), Essential for male fertility and spermatogenesis (PubMed:31453335, PubMed:32374261, PubMed:32352380, PubMed:32744506), Required for meiosis prophase I progression in male but not in female germ cells (PubMed:31453335)


This is TNF receptor-associated factor 6 protein, from Zebrafish, contains 542 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation

Belongs to the TNF receptor-associated factor family, A subfamily


This is DNA polymerase kappa protein, from Mouse-ear cress, contains 671 amino acids, has 1 UBZ3-type Zinc finger.

Template-directed low-fidelity DNA polymerase specifically involved in DNA repair (PubMed:15200644, PubMed:17550419), Able to extend primer-terminal mispairs, and to insert nucleotides opposite to a single 7,8-dihydro-8-oxoGuanine (8-oxoG) lesion and moderately extend from the resulting primer end, thus leading to both error-free and error-prone bypass of 8-oxoG DNA lesions (PubMed:17550419), Probably involved in consecutive DNA replication cycles in the absence of mitosis (PubMed:15200644), Binds preferentially template-primer DNA substrates or single-stranded DNA (PubMed:17550419), Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls, Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts (By similarity)

Belongs to the DNA polymerase type-Y family


This is ZZ-type zinc finger-containing protein 3 protein, from Mouse, contains 910 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (By similarity), Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)


This is E3 ubiquitin-protein ligase TRIM39 protein, from Rat, contains 488 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase (By similarity), May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity), Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity), Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity)


This is E3 ubiquitin-protein ligase RING1 protein, from Rat, contains 406 amino acids, has 1 RING-type Zinc finger.

RING-type

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation, H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility, Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity)


This is Zinc finger protein 280D protein, from Human, contains 979 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate


This is DNA-directed RNA polymerases II, IV and V subunit 9A protein, from Mouse-ear cress, contains 114 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements, Required for RNA silencing

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is E3 ubiquitin-protein ligase XBAT32 protein, from Mouse-ear cress, contains 508 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of ACC synthases (ACS), Negatively regulates ethylene biosynthesis probably via ubiquitin-dependent degradation of ACS4 and ACS7 enzymes, Regulates lateral root formation and development by controlling ethylene production which inhibits lateral root formation at high concentration


This is Protein DAMAGED DNA-BINDING 2 protein, from Mouse-ear cress, contains 557 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 (By similarity), Required for DNA repair, Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex), The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:18551167), Involved in UV-B tolerance and genome integrity, In association with ATCSA-1, is necessary for repair of UV-B-induced DNA lesions (PubMed:20128879)

Belongs to the WD repeat DDB2/WDR76 family


This is Protein VACUOLELESS GAMETOPHYTES protein, from Mouse-ear cress, contains 248 amino acids, has 1 ZZ-type 1; degenerate Zinc finger, has 1 ZZ-type 2; degenerate Zinc finger.

ZZ-type 1; degenerate

ZZ-type 2; degenerate

Essential for development of both female (megagametogenesis) and male (microgametogenesis) gametophytes by promoting the formation of large vacuoles early in development, maybe via the regulation of vesicular fusion


This is E3 ubiquitin-protein ligase SH3RF1 protein, from African clawed frog, contains 826 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity, In the absence of an external substrate, it can catalyze self-ubiquitination, Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway (By similarity), Plays an essential role in the anterior neural development


This is E3 ubiquitin-protein ligase rnf8-B protein, from African clawed frog, contains 532 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites, Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF), H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins, In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation


This is E3 ubiquitin-protein ligase TRAIP protein, from African clawed frog, contains 464 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:30979826, PubMed:30849395, PubMed:30842657), Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (PubMed:30979826, PubMed:30849395, PubMed:30842657), Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of mcm7 subunit of the CMG helicase complex (PubMed:30842657), Short ubiquitin chains on mcm7 promote recruitment of DNA glycosylase neil3 (PubMed:30842657), If the interstrand cross-link cannot be cleaved by neil3, the ubiquitin chains continue to grow on mcm7, promoting the unloading of the CMG helicase complex by the vcp/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (PubMed:30979826, PubMed:30842657), Only catalyzes ubiquitination of mcm7 when forks converge (PubMed:30842657), Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (PubMed:30595436), Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (By similarity)


This is Diacylglycerol kinase beta protein, from Mouse, contains 802 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:20657643), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable), Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity), Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (PubMed:20657643)

Belongs to the eukaryotic diacylglycerol kinase family


This is Zinc finger protein 746 protein, from Human, contains 644 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death


This is Zinc finger protein 774 protein, from Human, contains 483 amino acids, has 12 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Histone deacetylase complex subunit SAP30L protein, from Zebrafish, contains 178 amino acids, has 1 Atypical Zinc finger.

Atypical

Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:22821512), Required for normal expression of numerous target genes (PubMed:22821512), Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus, Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA, Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (By similarity)


This is Fanconi anemia core complex-associated protein 20 protein, from Human, contains 180 amino acids, has 1 UBZ2-type Zinc finger.

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair, Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex, Promotes translesion synthesis via interaction with REV1


This is E3 ubiquitin-protein ligase MARCHF1 protein, from Mouse, contains 289 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system


This is Zinc finger CCHC domain-containing protein 8 protein, from Human, contains 707 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484), NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation, May be involved in pre-mRNA splicing (Probable), It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579)


This is Insulinoma-associated protein 1a protein, from Zebrafish, contains 383 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

May act as a transcriptional regulator, May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity)


This is Zinc finger protein 343 protein, from Human, contains 599 amino acids, has 12 C2H2-type Zinc finger.


This is Histone-lysine N-methyltransferase PRDM9 protein, from Zebrafish, contains 853 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger, has 1 C2H2-type 10; degenerate Zinc finger.

C2H2-type 5; degenerate

C2H2-type 6; degenerate

C2H2-type 10; degenerate

Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination, Can also methylate all four core histones with H3 being the best substrate and the most highly modified, Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate, During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity, Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression, During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema, EWSR1 joins PRDM9 with the chromosomal axis through REC8, In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation, Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation, In addition performs automethylation, Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation


This is Zinc finger protein 1 homolog protein, from Human, contains 407 amino acids, has 8 C2H2-type Zinc finger.


This is Diacylglycerol kinase theta protein, from Mouse, contains 934 amino acids, has 3 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:26748701), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:26748701), Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity), Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity), Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701)


This is MBT domain-containing protein 1 protein, from Mouse, contains 631 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR), MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively), In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me, Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR)


This is Protrudin protein, from Rat, contains 404 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457), Promotes axonal elongation and contributes to the establishment of neuronal cell polarity, Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner, Contributes to both the formation and stabilization of the tubular ER network, Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections, Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons, Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (By similarity)


This is E3 ubiquitin ligase TRIM40 protein, from Human, contains 258 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565), Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709), Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709)


This is Zinc finger protein 449 protein, from Human, contains 518 amino acids, has 7 C2H2-type Zinc finger.


This is ATM interactor protein, from Mouse, contains 818 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Transcription factor, Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage, Involved in regulating the activity of ATM in the absence of DNA damage, May play a role in stabilizing ATM (By similarity), Binds to the DYNLL1 promoter and activates its transcription


This is Ubiquitin carboxyl-terminal hydrolase 16 protein, from African clawed frog, contains 901 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator, Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis, Regulates Hox gene expression via histone H2A deubiquitination, Prefers nucleosomal substrates, Does not deubiquitinate histone H2B

Belongs to the peptidase C19 family, USP16 subfamily


This is F-box/LRR-repeat protein 19 protein, from Mouse, contains 674 amino acids, has 1 CXXC-type Zinc finger, has 1 PHD-type Zinc finger.

CXXC-type

PHD-type

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:28453857, PubMed:29809150), Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner, Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration, Mediates also ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (PubMed:22660580), Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:28453857, PubMed:29809150), Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation (PubMed:29809150), In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (PubMed:28453857)


This is E3 ubiquitin-protein ligase RFWD3 protein, from Human, contains 774 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658), Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929), Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658), Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098), May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098), In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098)