This is Postreplication repair E3 ubiquitin-protein ligase RAD18 protein, from Baker's yeast, contains 487 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group, Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA, The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR, The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine


This is Hyaluronan and proteoglycan link protein 1 protein, from Human, contains 354 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix

Secreted, extracellular space, extracellular matrix


This is T-cell surface glycoprotein CD8 beta chain protein, from Human, contains 210 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex, The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched, Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs), Additionally, plays a critical role in thymic selection of CD8+ T-cells


This is E3 SUMO-protein ligase EGR2 protein, from Human, contains 476 amino acids, has 3 C2H2-type Zinc finger.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity

Belongs to the EGR C2H2-type zinc-finger protein family


This is Gag polyprotein protein, from Radiation murine leukemia virus, contains 537 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome, Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome, This binding is dependent on genome dimerization


This is Gag polyprotein protein, from MMTV, contains 591 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is RAF proto-oncogene serine/threonine-protein kinase protein, from Rat, contains 648 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation, RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2), The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75', Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation, Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity, Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1), Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death, Regulates Rho signaling and migration, and is required for normal wound healing, Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN, Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity), Phosphorylates TNNT2/cardiac muscle troponin T

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is Raf homolog serine/threonine-protein kinase Raf protein, from Fruit fly, contains 739 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Serine/threonine kinase required in the early embryo for the formation of terminal structure (PubMed:3135183, PubMed:8423783), Also required during the proliferation of imaginal cells (PubMed:3135183), May act downstream of Ras85D in the tor signal transduction pathway (PubMed:8423783), During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758)


This is Fibroblast growth factor receptor 1 protein, from Human, contains 822 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration, Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system, Phosphorylates PLCG1, FRS2, GAB1 and SHB, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2, In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription, FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Retinoic acid receptor alpha protein, from Mouse, contains 462 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid (PubMed:17205979), Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:17205979), The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:17205979), In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity), On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:17205979, PubMed:9230306, PubMed:19078967), Formation of heterocomplex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (By similarity), Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (By similarity), RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (PubMed:15901285), Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (PubMed:15901285, PubMed:17905941), In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (PubMed:10660575, PubMed:17905941), In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355), Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity), In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Pregnancy-specific beta-1-glycoprotein 1 protein, from Human, contains 419 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, CEA family


This is Vitamin D3 receptor protein, from Human, contains 427 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179), Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609), The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609), Plays a central role in calcium homeostasis (By similarity), Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638)


This is Steroid hormone receptor ERR1 protein, from Human, contains 423 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3', Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter, Binds to the C1 region of the lactoferrin gene promoter, Requires dimerization and the coactivator, PGC-1A, for full activity, The ERRalpha/PGC1alpha complex is a regulator of energy metabolism, Induces the expression of PERM1 in the skeletal muscle

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Steroid hormone receptor ERR2 protein, from Rat, contains 433 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (By similarity), Plays a role, in a LIF independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways, Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells, Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity), Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (By similarity), Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity), During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase, Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation, This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program, Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity)


This is Antigen-presenting glycoprotein CD1d1 protein, from Mouse, contains 336 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells


This is Antigen-presenting glycoprotein CD1d2 protein, from Mouse, contains 336 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is B-cell antigen receptor complex-associated protein alpha chain protein, from Mouse, contains 220 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation, Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells, Stimulates SYK autophosphorylation and activation, Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK, Also interacts with and increases activity of some Src-family tyrosine kinases, Represses BCR signaling during development of immature B-cells


This is B-cell antigen receptor complex-associated protein alpha chain protein, from Human, contains 226 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type


This is T-cell surface glycoprotein CD3 gamma chain protein, from Mouse, contains 182 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways, In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface, Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G (PubMed:25920998)


This is Immunoglobulin iota chain protein, from Human, contains 145 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells, This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation

Belongs to the immunoglobulin superfamily


This is High affinity immunoglobulin gamma Fc receptor I protein, from Human, contains 374 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

High affinity receptor for the Fc region of immunoglobulins gamma, Functions in both innate and adaptive immune responses, Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells

Belongs to the immunoglobulin superfamily, FCGR1 family


This is Low affinity immunoglobulin gamma Fc region receptor II-a protein, from Human, contains 317 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Binds to the Fc region of immunoglobulins gamma, Low affinity receptor, By binding to IgG it initiates cellular responses against pathogens and soluble antigens, Promotes phagocytosis of opsonized antigens


This is High affinity immunoglobulin epsilon receptor subunit alpha protein, from Human, contains 257 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

High-affinity receptor for immunoglobulin epsilon/IgE, Mediates IgE effector functions in myeloid cells, Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation, On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes, Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity, When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions


This is High affinity immunoglobulin epsilon receptor subunit alpha protein, from Rat, contains 245 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like


This is Gag polyprotein protein, from HIV-2, contains 520 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Gag polyprotein protein, from HIV-1, contains 500 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-1, contains 501 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag polyprotein protein, from SIV-sm, contains 507 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1


This is Gag-Pol polyprotein protein, from HIV-1, contains 532 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Aspartyl protease that mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell, Also cleaves Nef and Vif, probably concomitantly with viral structural proteins on maturation of virus particles, Hydrolyzes host EIF4GI and PABP1 in order to shut off the capped cellular mRNA translation, The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response, Also mediates cleavage of host YTHDF3, Mediates cleavage of host CARD8, thereby activating the CARD8 inflammasome, leading to the clearance of latent HIV-1 in patient CD4(+) T-cells after viral reactivation; in contrast, HIV-1 can evade CARD8-sensing when its protease remains inactive in infected cells prior to viral budding (By similarity)


This is 43 kDa receptor-associated protein of the synapse protein, from Mouse, contains 412 amino acids, has 1 RING-type Zinc finger.

RING-type

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction, It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity)


This is Nuclear receptor subfamily 4 group A member 1 protein, from Mouse, contains 601 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration, Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3', May inhibit NF-kappa-B transactivation of IL2, Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity), Plays a role in the vascular response to injury (PubMed:22427340)

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is Vitamin D3 receptor protein, from Rat, contains 423 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:17227670), Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity), The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity), Plays a central role in calcium homeostasis (PubMed:17227670), Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)


This is Nuclear receptor subfamily 2 group C member 1 protein, from Human, contains 603 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism, Primarily repressor of a broad range of genes, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription, Also activator of OCT4 gene expression, May be involved in stem cell proliferation and differentiation, Mediator of retinoic acid-regulated preadipocyte proliferation

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is mRNA export factor ICP27 homolog protein, from SaHV-2, contains 417 amino acids, has 1 CHC2-type Zinc finger.

Probably acts as a viral splicing factor that regulates viral RNA splicing, Functions as a multifunctional regulator of the expression of viral lytic genes (By similarity), Early protein that promotes the accumulation and nuclear export of viral intronless RNA transcripts by interacting with mRNAs and cellular export proteins

Belongs to the HHV-1 ICP27 protein family


This is Protein glass protein, from Fruit fly, contains 604 amino acids, has 5 C2H2-type Zinc finger.

Transcription factor required for gene expression specific to photoreceptor cells


This is Macrophage colony-stimulating factor 1 receptor protein, from Cat, contains 980 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes, Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development, Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy, Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion, Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity), Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL, Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD, Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway, Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1, Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2, Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B, Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1, Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor (By similarity), In the central nervous system, may play a role in the development of microglia macrophages (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Interleukin-1 receptor type 1 protein, from Mouse, contains 576 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Unable to mediate canonical IL-1 signaling, Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation

Belongs to the interleukin-1 receptor family


This is Neural cell adhesion molecule 1 protein, from Human, contains 858 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for Zika virus


This is Neural cell adhesion molecule 1 protein, from Rat, contains 858 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc


This is Intercellular adhesion molecule 1 protein, from Mouse, contains 537 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity)

Belongs to the immunoglobulin superfamily, ICAM family


This is Intercellular adhesion molecule 2 protein, from Human, contains 275 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion, It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance


This is IgG receptor FcRn large subunit p51 protein, from Rat, contains 366 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn, Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:18818657, PubMed:7969498), IgG in the milk is bound at the apical surface of the intestinal epithelium, The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (PubMed:7298722, PubMed:18818657), Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation, Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation, In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (By similarity)


This is Retinoic acid receptor gamma protein, from Human, contains 454 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors, Required for limb bud development, In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity)


This is Protein kinase C, eye isozyme protein, from Fruit fly, contains 700 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme, This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation, Negative regulation is dependent on interaction with scaffolding protein inaD, Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Protein kinase C protein, from Fruit fly, contains 739 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins, PKC also serves as the receptor for phorbol esters, a class of tumor promoters


This is Zinc finger protein 35 protein, from Human, contains 527 amino acids, has 11 C2H2-type Zinc finger.

May be involved in transcriptional regulation, Involved in cell differentiation and/or proliferation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Carcinoembryonic antigen-related cell adhesion molecule 1 protein, from Human, contains 526 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity), Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity)


This is HLA class I histocompatibility antigen, alpha chain E protein, from Human, contains 358 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

(Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32859121), Binds SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121)


This is Patr class I histocompatibility antigen, A-108 alpha chain protein, from Chimpanzee, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is Patr class I histocompatibility antigen, A-126 alpha chain protein, from Chimpanzee, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Patr class I histocompatibility antigen, B-1 alpha chain protein, from Chimpanzee, contains 359 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Patr class I histocompatibility antigen, B-2 alpha chain protein, from Chimpanzee, contains 362 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is BOLA class I histocompatibility antigen, alpha chain BL3-6 protein, from Bovine, contains 360 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is BOLA class I histocompatibility antigen, alpha chain BL3-7 protein, from Bovine, contains 364 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is HLA class II histocompatibility antigen, DR beta 4 chain protein, from Human, contains 266 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells, The peptide binding cleft accommodates peptides of 10-30 residues, The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases, Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous, As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components, Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments, In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract, To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer, Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide), The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released, HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound, The MHC II molecule bound to a peptide is then transported to the cell membrane surface, In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO, Primary dendritic cells (DCs) also to express HLA-DO, Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading


This is HLA class II histocompatibility antigen, DO beta chain protein, from Human, contains 273 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells, Modifies peptide exchange activity of HLA-DM


This is Serine/threonine-protein kinase A-Raf protein, from Rat, contains 604 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus, May also regulate the TOR signaling cascade (By similarity), Phosphorylates PFKFB2 (By similarity)


This is Gag-Pro polyprotein protein, from HTLV-1, contains 651 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell (Potential), Cleaves the translation initiation factor eIF4G leading to the inhibition of host cap-dependent translation (By similarity)


This is Gag polyprotein protein, from HTLV-1, contains 429 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Binds strongly to viral nucleic acids and promote their aggregation, Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs


CCHC-type

CCHC-type


This is Protein Tax-1 protein, from HTLV-1, contains 353 amino acids, has 1  Zinc finger.

Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways, Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE), Binding to TRE requires the interaction with CREB1 and CREBBP, Also induces chromatin remodeling of proviral LTR-mediated gene expression by recruiting the histone acetyl transferases CREBBP and EP300 to the chromatin, which results in histone acetylation, Via its interaction with IKK regulatory subunit IKBKG, Tax-1 persistently stimulates I-kappa-B kinase (IKK), resulting in constitutive activation of the transcription factor NF-kappa-B, Induction of the nuclear expression of members of the NFkB family of transcription factors, which leads to up-regulated expression of many gene promoters containing NFkB motifs, These genes include those encoding IL2, IL15, IL2RA and IL15RA, leading to autocrine IL2/IL2RA and IL15/IL15RA loops, The resulting T-cell proliferation leads to malignant transformation and to the development of adult T-cell leukemia (ATL), IL13, known to be linked to leukemogenesis, is also up-regulated by Tax-1, Interaction with PDZ domain-containing proteins induce IL2-independent growth, which may be a factor in multi-step leukemogenesis, Inhibits the action of at least three cellular tumor suppressors p53/TP53, RB1 and DLG1, and suppresses their abilities to dictate apoptosis in primary cells, Required for viral replication (By similarity)

Belongs to the deltaretrovirus Tax protein family


This is Protein ref(2)P protein, from Fruit fly, contains 599 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Required for selective autophagy activation by ubiquitinated proteins (PubMed:22622177), Implicated in sigma rhabdovirus multiplication and necessary for male fertility, Involved in activating transcription of Drs (PubMed:12446795, PubMed:2510997)


This is Zinc finger protein RFP protein, from Human, contains 513 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

(Microbial infection) Positively regulates hepatitis C virus replication by suppressing type I IFN response during infection


This is H-2 class I histocompatibility antigen, D-K alpha chain protein, from Mouse, contains 362 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class I histocompatibility antigen, D-P alpha chain protein, from Mouse, contains 368 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class I histocompatibility antigen, K-Q alpha chain protein, from Mouse, contains 328 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class I histocompatibility antigen, Q7 alpha chain protein, from Mouse, contains 334 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class I histocompatibility antigen, Q8 alpha chain protein, from Mouse, contains 326 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class I histocompatibility antigen, TLA(B) alpha chain protein, from Mouse, contains 384 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-B alpha chain protein, from Mouse, contains 256 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-F alpha chain protein, from Mouse, contains 233 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-R alpha chain protein, from Mouse, contains 233 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-S alpha chain protein, from Mouse, contains 233 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-U alpha chain protein, from Mouse, contains 227 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, E-U alpha chain protein, from Mouse, contains 255 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A beta chain protein, from Mouse, contains 265 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Interleukin-1 receptor-like 1 protein, from Mouse, contains 567 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Interleukin-1 receptor type 1 protein, from Human, contains 569 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for IL1A, IL1B and IL1RN (PubMed:2950091), After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways, Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits, Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex, Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850)


This is Serine/threonine-protein kinase B-raf protein, from Human, contains 766 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable), Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126), Phosphorylates PFKFB2 (PubMed:36402789), May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is Polymeric immunoglobulin receptor protein, from Rat, contains 769 amino acids, has 1 Ig-like V-type 1; required for binding to polymeric IgA and IgM Immunoglobulin domain, has 4 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens, On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells


This is Poliovirus receptor protein, from Human, contains 417 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells


This is Thyroid hormone receptor alpha-A protein, from African clawed frog, contains 418 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

High affinity receptor for triiodothyronine (T3)


This is Androgen receptor protein, from Rat, contains 902 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation, Transcription activation is also down-regulated by NR0B2, Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity)


This is BDNF/NT-3 growth factors receptor protein, from Mouse, contains 821 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation, Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions, Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is Fasciclin-3 protein, from Fruit fly, contains 508 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Mediates cell adhesion in a Ca(2+)-independent manner, It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system


This is Cyclic AMP-dependent transcription factor ATF-2 protein, from Human, contains 505 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response, Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'), In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death, In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death, The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF), Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277), In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM, Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type

Belongs to the bZIP family, ATF subfamily


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Fruit fly, contains 156 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome, Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is Protein embryonic gonad protein, from Fruit fly, contains 373 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

May play a critical role in development of the progeny of eagle-positive neuroblasts

Belongs to the nuclear hormone receptor family, NR0 subfamily


This is B-lymphocyte antigen CD19 protein, from Human, contains 556 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes, Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701), Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701), Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126), Required for normal differentiation of B-1 cells (By similarity), Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518), Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701)


This is Proto-oncogene vav protein, from Human, contains 845 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation


This is B-cell antigen receptor complex-associated protein beta chain protein, from Mouse, contains 228 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation, Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation


This is Tripartite motif-containing protein 30A protein, from Mouse, contains 496 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain, May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences, Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination, Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex, This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18, No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses


This is Zinc finger protein 250 protein, from Human, contains 560 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is T-cell surface glycoprotein CD1e, membrane-associated protein, from Human, contains 388 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface, The membrane-associated form is not active


This is Antigen-presenting glycoprotein CD1d protein, from Human, contains 335 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells


This is Immunoglobulin lambda-like polypeptide 1 protein, from Human, contains 213 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Gag polyprotein protein, from HIV-2, contains 521 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1


This is N-chimaerin protein, from Human, contains 459 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

GTPase-activating protein for p21-rac and a phorbol ester receptor, Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance


This is Erythroid transcription factor protein, from Human, contains 413 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251), It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells, Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781)


This is T-cell surface glycoprotein CD4 protein, from Chimpanzee, contains 458 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is Protein kinase C epsilon type protein, from Mouse, contains 737 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis, Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts, Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes, Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein, In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact, Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration, During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA, In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1, During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length, Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3), Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement, May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation, Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol, Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons, Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2,2), Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production, In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2, May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1, Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (By similarity)


This is Estrogen receptor protein, from Rainbow trout, contains 622 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Fibroblast growth factor receptor 1 protein, from Mouse, contains 822 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration, Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system, Phosphorylates PLCG1, FRS2, GAB1 and SHB, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2, In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription, FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Patr class I histocompatibility antigen, A-2 alpha chain protein, from Chimpanzee, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is Patr class I histocompatibility antigen, A-5 alpha chain protein, from Chimpanzee, contains 362 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Popy Class I histocompatibility antigen, A-1 alpha chain protein, from Bornean orangutan, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Popy class I histocompatibility antigen, alpha chain E protein, from Bornean orangutan, contains 359 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Platelet endothelial cell adhesion molecule protein, from Human, contains 738 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Steroid receptor seven-up, isoforms B/C protein, from Fruit fly, contains 543 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor that is required in photoreceptors R1, R3, R4 and R6 during eye development; generation of the ganglion mother cell-2 (GMC-2) fate in the nb7-3 lineage, coinciding with the transition in the expression of HB to KR in the neuroblasts (NBs)


This is Steroid receptor seven-up, isoform A protein, from Fruit fly, contains 746 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is RT1 class I histocompatibility antigen, AA alpha chain protein, from Rat, contains 371 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Cytotoxic T-lymphocyte protein 4 protein, from Human, contains 223 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor acting as a major negative regulator of T-cell responses, The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28


This is Carcinoembryonic antigen-related cell adhesion molecule 1 protein, from Rat, contains 519 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion proteins that mediates homophilic cell adhesion in a calcium-independent manner (PubMed:8536699, PubMed:7774714), Promotes populations of T-cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity)

Belongs to the immunoglobulin superfamily, CEA family


This is Cyclic AMP-dependent transcription factor ATF-2 protein, from Mouse, contains 487 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response, Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'), In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death, In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death, The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF), Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro, In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM, Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (By similarity)


This is Zinc finger X-chromosomal protein protein, from Human, contains 805 amino acids, has 13 C2H2-type Zinc finger.

Belongs to the krueppel C2H2-type zinc-finger protein family, ZFX/ZFY subfamily


This is Zinc finger X-chromosomal protein protein, from Mouse, contains 799 amino acids, has 13 C2H2-type Zinc finger.


This is Zinc finger protein 12 protein, from Human, contains 697 amino acids, has 15 C2H2-type Zinc finger.

Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity


This is Zinc finger protein 16 protein, from Human, contains 682 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 15 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

Acts as a transcriptional activator, Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase, Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively, Also plays a role as an inhibitor of cell apoptosis


This is Zinc finger protein 17 protein, from Human, contains 662 amino acids, has 16 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein 18 protein, from Human, contains 549 amino acids, has 5 C2H2-type Zinc finger.


This is Zinc finger protein 19 protein, from Human, contains 458 amino acids, has 9 C2H2-type Zinc finger, has 1 C2H2-type 10; atypical Zinc finger.

C2H2-type 10; atypical


This is Zinc finger protein 20 protein, from Human, contains 532 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 12 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; degenerate

C2H2-type 3; degenerate


This is Zinc finger protein 23 protein, from Human, contains 643 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 16 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation, May have a role in embryonic development


This is Zinc finger protein 24 protein, from Human, contains 368 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor required for myelination of differentiated oligodendrocytes, Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state, In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle, Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity), Has transcription repressor activity in vitro


This is Zinc finger protein 3 protein, from Human, contains 446 amino acids, has 8 C2H2-type Zinc finger.

Involved in cell differentiation and/or proliferation


This is Zinc finger protein 32 protein, from Human, contains 273 amino acids, has 6 C2H2-type Zinc finger, has 1 C2H2-type 7; degenerate Zinc finger.

C2H2-type 7; degenerate


This is Protein kinase C alpha type protein, from Human, contains 672 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP, Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle, Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells, In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B, Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2, During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development, After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion, Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility, During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151), Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers, Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries, Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area, Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility, In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation, Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation, In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion, During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation, But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA), Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation, Phosphorylates KIT, leading to inhibition of KIT activity, Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription, Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity)


This is Gag polyprotein protein, from SIV-cpz, contains 508 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Nitrogen regulatory protein areA protein, from Aspergillus nidulans, contains 876 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcription activator that binds the consensus DNA element 5'-CGATAG-3' and mediates nitrogen metabolite repression, Activates the transcription of uapA


This is mRNA decay activator protein ZFP36L1 protein, from Rat, contains 338 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10751406, PubMed:12748283), Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:12748283), Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:12748283), Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (PubMed:11279239), Binds to 3'-UTR ARE of numerous mRNAs (PubMed:10751406), Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs), Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress, Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA, Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA, Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation, May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA, In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation, Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA, Participates in the delivery of target ARE-mRNAs to processing bodies (PBs), In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells, Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion, Plays a role in vasculogenesis and endocardial development, Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis, Plays a role in myoblast cell differentiation (By similarity)


This is Cyclic AMP-dependent transcription factor ATF-7 protein, from Human, contains 483 amino acids, has 1 C2H2-type Zinc finger.

Acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities, It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation


This is Erythroid transcription factor protein, from Chicken, contains 304 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator or repressor which serves as a general switch factor for erythroid development, It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells


This is Erythroid transcription factor protein, from Mouse, contains 413 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development, It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells, Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (By similarity)


This is HLA class I histocompatibility antigen, alpha chain G protein, from Human, contains 338 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Likely does not bind B2M and presents peptides


This is Gag polyprotein protein, from HIV-2, contains 521 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1


This is Protein tramtrack, beta isoform protein, from Fruit fly, contains 643 amino acids, has 2 C2H2-type Zinc finger.

Binds to a number of sites in the transcriptional regulatory region of ftz (PubMed:2104801), Isoform beta is required to repress inappropriate segmentation gene transcription and repress genes incompatible with development of photoreceptor cell fates (PubMed:12384587, PubMed:18160715), Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en (PubMed:8223261), Inhibits Trl-dependent activation of eve (PubMed:12384587), May bind to the region AGGGC/TGG (PubMed:8247159), Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk (PubMed:18160715, PubMed:17962185), A second method of degradation exists that is phyl-independent, this is mediated by recognition of motifs in the C-terminus of ttk (PubMed:17962185)


This is Basigin protein, from Chicken, contains 388 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Ig-like V-type

Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity), Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (By similarity), Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity), Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity)


This is Primosomal protein N' protein, from Escherichia coli (strain K12), contains 732 amino acids, has 2 C4-type Zinc finger.

Involved in the restart of stalled replication forks, Recognizes and binds the arrested nascent DNA chain at stalled replication forks, It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA, Is also involved in initiation of normal DNA replication in various plasmids and phages, Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS), Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition

Belongs to the helicase family, PriA subfamily


This is Gag polyprotein protein, from HIV-2, contains 522 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


CCHC-type

CCHC-type


This is Protein tailless protein, from Fruit fly, contains 452 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity, This receptor binds to the consensus sequence [AG][AG]AAGTCAA, Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo, It may also play a role in the nervous system, The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains, Involved in the regulation of early eye development, In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Thyroid hormone receptor beta protein, from Rat, contains 461 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Thyroid hormone receptor alpha-B protein, from African clawed frog, contains 418 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

High affinity receptor for triiodothyronine (T3)


This is Thyroid hormone receptor beta-A protein, from African clawed frog, contains 373 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Early growth response protein 1 protein, from Human, contains 543 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator (PubMed:20121949), Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity), Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311), Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia, Plays a role in the regulation of cell survival, proliferation and cell death, Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation, Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy, Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia, Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity), Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription, Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity)

Belongs to the EGR C2H2-type zinc-finger protein family


This is CD48 antigen protein, from Mouse, contains 240 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:9881969, PubMed:21278219), Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex, In turn, promotes LCK phosphorylation and subsequent activation (PubMed:9881969), Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (By similarity) (PubMed:9881969, PubMed:21278219)


This is Rano class II histocompatibility antigen, D-1 beta chain protein, from Rat, contains 264 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is Fibroblast growth factor receptor 3 protein, from Chicken, contains 806 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis, Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development, Regulates both osteogenesis and postnatal bone mineralization by osteoblasts, Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation, Phosphorylates PLCG1, CBL and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)


This is Fibroblast growth factor receptor 2 protein, from Chicken, contains 823 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development, Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development, Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development, Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts, Phosphorylates PLCG1, FRS2 and PAK4, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation, Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling, Over-expressed FGFR2 promotes activation of STAT1 (By similarity)


This is H-2 class II histocompatibility antigen, I-A beta chain protein, from Mouse, contains 264 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, I-E beta chain protein, from Mouse, contains 264 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Nitrogen regulatory protein GLN3 protein, from Baker's yeast, contains 730 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Positive nitrogen regulatory protein, Required for the activation of transcription of a number of genes (including the allantoin pathway genes) in response to the replacement of glutamine by glutamate as source of nitrogen, Binds the nitrogen upstream activation sequence of GLN1, the gene encoding glutamine synthetase, URE2 may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine


This is RING finger protein Z protein, from LCMV, contains 90 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a crucial role in virion assembly and budding, Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L, Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP, Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway, The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z, Also selectively represses protein production by associating with host eIF4E

Belongs to the arenaviridae Z protein family


This is Basigin protein, from Mouse, contains 389 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Ig-like V-type

Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity), Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane (PubMed:12601063), Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity), Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity), Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (PubMed:23727514, PubMed:11882021)


This is Lymphocyte activation gene 3 protein protein, from Human, contains 525 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response


This is Gag polyprotein protein, from HIV-1, contains 497 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Garden pea, contains 590 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Retinoic acid receptor gamma protein, from Mouse, contains 458 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity), Required for limb bud development, In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function


This is Androgen receptor protein, from Mouse, contains 899 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation, Transcription activation is also down-regulated by NR0B2, Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3


This is Lymphocyte function-associated antigen 3 protein, from Human, contains 250 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Ligand of the T-lymphocyte CD2 glycoprotein, This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes, In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells


This is Vascular cell adhesion protein 1 protein, from Human, contains 739 amino acids, has 7 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649), Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034), During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700), Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567)


This is Protein snail homolog Sna protein, from African clawed frog, contains 259 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional repressor, Acts upstream of snai2/slug, zic5 and other neural crest markers in the specification of the neural crest and neural crest migration, Involved in embryonic mesoderm formation

Belongs to the snail C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase TRIM21 protein, from Human, contains 475 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2, Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination, Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes, A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome, Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling, Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3, Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway, Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages, Plays a role in the regulation of the cell cycle progression, Enhances the decapping activity of DCP2, Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules, At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified, The common feature of these proteins is their ability to bind HY RNAs,2, Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma, Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy, Regulates also autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability (PubMed:36359729), Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139, PubMed:16297862, PubMed:16316627, PubMed:16472766, PubMed:16880511, PubMed:18022694, PubMed:18361920, PubMed:18641315, PubMed:18845142, PubMed:19675099), Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI (PubMed:26342464), During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation (PubMed:36426955), When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity (PubMed:29743353)