This is Transcription factor Ovo-like 2 protein, from Human, contains 275 amino acids, has 4 C2H2-type Zinc finger.

Zinc-finger transcription repressor factor (PubMed:19700410), Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity), Positively regulates neuronal differentiation (By similarity), Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410), Important for the correct development of primordial germ cells in embryos (By similarity), Plays dual functions in thermogenesis and adipogenesis to maintain energy balance, Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes, In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity)


This is Pygopus homolog 2 protein, from Human, contains 406 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Involved in signal transduction through the Wnt pathway


This is Zinc finger protein with KRAB and SCAN domains 3 protein, from Human, contains 538 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy, Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2, Associates with chromatin at the ITGB4 and VEGF promoters, Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase TRIM56 protein, from Human, contains 755 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904), In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity), Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904), Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha (PubMed:35952808), Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling, Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160), Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160), Acts as restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region (PubMed:31251739)


This is Zinc finger protein 670 protein, from Human, contains 389 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 9; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 2 protein, from Human, contains 425 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 9; degenerate


This is Polycomb group RING finger protein 1 protein, from Human, contains 259 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A, Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway, Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element), Promotes cell cycle progression and enhances cell proliferation as well, May have a positive role in tumor cell growth by down-regulating CDKN1A, Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332), Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479)


This is THAP domain-containing protein 7 protein, from Human, contains 309 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors


This is Metastasis-associated protein MTA3 protein, from Human, contains 594 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12705869, PubMed:28977666), Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869), Contributes to transcriptional repression by BCL6 (PubMed:15454082)


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 3 protein, from Human, contains 628 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Promotes neurite outgrowth in hippocampal neurons (By similarity)


This is Zinc finger BED domain-containing protein 2 protein, from Human, contains 218 amino acids, has 1 BED-type Zinc finger.

BED-type

Transcriptional regulator which has intrinsic repressor activity and which competes with the transcriptional activator IRF1 for binding to the 5'-[CA]GAA[AC]C[CT]-3' consensus sequence in gene promoters (PubMed:32385160), May thereby play a role in keratinocyte differentiation (PubMed:31552090)


This is Zinc finger protein 692 protein, from Human, contains 519 amino acids, has 5 C2H2-type Zinc finger.

May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway


This is PHD finger protein 23 protein, from Human, contains 403 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria


This is Zinc finger protein 426 protein, from Human, contains 554 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 11 C2H2-type Zinc finger.

C2H2-type 1; atypical


This is TNF receptor-associated factor 4 protein, from Human, contains 470 amino acids, has 1 RING-type Zinc finger, has 3 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

TRAF-type

Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522), Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854), Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633), Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935), In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522), Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors, Required for normal skeleton development, and for normal development of the respiratory tract (By similarity), Required for activation of RPS6KB1 in response to TNF signaling, Modulates TRAF6 functions, Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273)

Belongs to the TNF receptor-associated factor family, B subfamily


This is Melanophilin protein, from Human, contains 600 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab effector protein involved in melanosome transport, Serves as link between melanosome-bound RAB27A and the motor protein MYO5A


This is E3 ubiquitin-protein ligase RNF126 protein, from Human, contains 311 amino acids, has 1 C4-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174), Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity), Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome, Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515), May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455), May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353), By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136), May monoubiquitinate AICDA (PubMed:23277564)


This is E3 ubiquitin-protein ligase TRIM62 protein, from Human, contains 475 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816), E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750)


This is Replication initiator 1 protein, from Human, contains 567 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 14 C2H2-type Zinc finger.

C2H2-type 1; atypical

Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication, Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone, Facilitates DNA bending


This is E3 ubiquitin-protein ligase TRAIP protein, from Human, contains 469 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26781088, PubMed:27462463, PubMed:26711499, PubMed:26595769, PubMed:31545170), Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity), Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity), Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity), If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity), Only catalyzes ubiquitination of MCM7 when forks converge (By similarity), Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity), Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286), The function in translesion synthesis is however controversial (PubMed:26595769), Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891), Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920), Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920)


This is RNA-binding protein 4 protein, from Human, contains 364 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation, Modulates alternative 5'-splice site and exon selection, Acts as a muscle cell differentiation-promoting factor, Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation, Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin, Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs, Required for the translational activation of PER1 mRNA in response to circadian clock, Binds directly to the 3'-UTR of the PER1 mRNA, Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation, Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress, Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions, Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs, Associates with miRNAs during muscle cell differentiation, Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro


This is Sodium channel modifier 1 protein, from Human, contains 230 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634), Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634)


This is Transcriptional repressor scratch 1 protein, from Human, contains 348 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; atypical Zinc finger.

C2H2-type 5; atypical

Transcriptional repressor that binds E-box motif CAGGTG, Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation

Belongs to the snail C2H2-type zinc-finger protein family


This is PHD finger protein 7 protein, from Human, contains 381 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type Zinc finger, has 1 RING-type; degenerate Zinc finger.

C2HC pre-PHD-type

PHD-type

RING-type; degenerate


This is Transcription factor GATA-5 protein, from Human, contains 397 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcription factor required during cardiovascular development (PubMed:23289003), Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity), Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888)


This is Tapasin-related protein protein, from Human, contains 468 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M, Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC)


This is Junctional adhesion molecule C protein, from Human, contains 310 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis

Belongs to the immunoglobulin superfamily


This is Endogenous retrovirus group K member 6 Pol protein protein, from Human, contains 956 amino acids, has 1 Integrase-type Zinc finger.

Integrase-type

Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA, The RNase H domain of the reverse transcriptase performs two functions, It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid, Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome, Endogenous Pol proteins may have kept, lost or modified their original function during evolution

Belongs to the beta type-B retroviral polymerase family, HERV class-II K(HML-2) pol subfamily


This is Cell adhesion molecule 1 protein, from Human, contains 442 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:22438059, PubMed:12050160), Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity), Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952), In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536), CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059), By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity), Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity), Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity), Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity), May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity), May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity), Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973), May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246)


This is E3 ubiquitin-protein ligase RNF26 protein, from Human, contains 433 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102), Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1 (PubMed:27368102, PubMed:33472082), Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082), Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379, PubMed:32614325), Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379)


This is Polycomb group RING finger protein 6 protein, from Human, contains 350 amino acids, has 1 RING-type Zinc finger.

RING-type

Transcriptional repressor (PubMed:12167161), May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162), Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332)


This is E3 ubiquitin-protein ligase TRIM34 protein, from Human, contains 488 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853), Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853), During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966), In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966), Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709), Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507)


This is RanBP-type and C3HC4-type zinc finger-containing protein 1 protein, from Human, contains 510 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448), Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548), Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448), Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:19136968), LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:19136968), Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181), LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:19136968), The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331), LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331), The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331), Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998), Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181)


This is Zinc finger protein 341 protein, from Human, contains 854 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 11 C2H2-type Zinc finger.

C2H2-type 1; atypical

Transcriptional activator of STAT3 involved in the regulation of immune homeostasis, Also able to activate STAT1 transcription


This is Tripartite motif-containing protein 54 protein, from Human, contains 358 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

May bind and stabilize microtubules during myotubes formation


This is Tripartite motif-containing protein 55 protein, from Human, contains 548 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

May regulate gene expression and protein turnover in muscle cells


This is Zinc finger protein GLIS2 protein, from Human, contains 524 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context, Acts as a repressor of the Hedgehog signaling pathway (By similarity), Represses the Hedgehog-dependent expression of Wnt4 (By similarity), Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity), Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway, May act by recruiting the corepressors CTBP1 and HDAC3, May be involved in neuron differentiation (By similarity)

Belongs to the GLI C2H2-type zinc-finger protein family


This is Serine/threonine-protein kinase D2 protein, from Human, contains 878 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613), May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity), In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613), In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809), Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180), During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity), In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771), During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391), In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217), Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381), In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756), Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978), Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is E3 ubiquitin-protein ligase TRIM8 protein, from Human, contains 551 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:27981609, PubMed:28747347), Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497), Plays a positive role in the TNFalpha and IL-1beta signaling pathways, Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791, PubMed:27981609, PubMed:34871740), Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148), Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347)


This is Forkhead box protein P3 protein, from Human, contains 431 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:30513302, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:32644293), Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781), Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479), The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479), Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681), Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565), Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532), Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049), Inhibits the transcriptional activator activity of RORA (PubMed:18354202), Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity)


This is Natural killer cell receptor 2B4 protein, from Human, contains 370 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776), Activating function implicates association with SH2D1A and FYN (PubMed:15713798), Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL, Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798), Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776), Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity), Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393), At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118), Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity), Inhibits inflammatory responses in dendritic cells (DCs) (By similarity)


This is E3 ubiquitin-protein ligase TRIM31 protein, from Human, contains 425 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:18773414, PubMed:27929086, PubMed:27992402), Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402), Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086), Regulator of Src-induced anchorage independent cell growth (By similarity)


This is E3 ubiquitin-protein ligase TRIM15 protein, from Human, contains 465 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:34142270, PubMed:23077300), Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368), Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296), Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300), Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1, Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740), Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs)


This is E3 ubiquitin-protein ligase TRIM9 protein, from Human, contains 710 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation, May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders, May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation


This is E3 ubiquitin-protein ligase TRIM7 protein, from Human, contains 511 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

(Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination


This is Tripartite motif-containing protein 6 protein, from Human, contains 488 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

(Microbial infection) Ubiquitinates ebolavirus protein VP35 leading to enhanced viral transcriptase activity


This is Tripartite motif-containing protein 5 protein, from Human, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811), Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057), Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057)


This is E3 ubiquitin-protein ligase TRIM4 protein, from Human, contains 500 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase, Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction


This is Tripartite motif-containing protein 2 protein, from Human, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11, Plays a neuroprotective function, May play a role in neuronal rapid ischemic tolerance, Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738)


This is INO80 complex subunit B protein, from Human, contains 356 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is RING finger protein unkempt homolog protein, from Human, contains 810 amino acids, has 5 C3H1-type Zinc finger, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development, Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system, Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif, Associated with polysomes (PubMed:25737280)


This is Semaphorin-4C protein, from Human, contains 833 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling, PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248', Required for normal brain development, axon guidance and cell migration (By similarity), Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade


This is Endoplasmic reticulum junction formation protein lunapark protein, from Human, contains 428 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983), Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977), May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289), May be involved in limb development (By similarity), Is involved in central nervous system development (PubMed:30032983)


This is Zinc finger protein 436 protein, from Human, contains 470 amino acids, has 12 C2H2-type Zinc finger.


This is B-cell lymphoma/leukemia 11B protein, from Human, contains 894 amino acids, has 6 C2H2-type Zinc finger.

Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals, Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755), Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611), Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity), May also function in the P53-signaling pathway (By similarity)


This is Extra-large guanine nucleotide-binding protein 3 protein, from Mouse-ear cress, contains 848 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity), Binds GTP with specificity, Plays a role in the root morphogenesis by regulation of the cell proliferation, Acts with GB1 in the positive regulation of root waving and root skewing

Belongs to the G-alpha family, XLG subfamily


This is Protein SUPPRESSOR OF FRI 4 protein, from Mouse-ear cress, contains 367 amino acids, has 1 BED-type Zinc finger.

BED-type

Sequence-specific DNA binding factor that recognizes the 5'-CCAAATTTTAAGTTT-3' sequence, Recruits the FRI-C complex to the FLC promoter, Required for FRI-mediated FLC activation, but has no effect on the expression of MAF1, MAF2, MAF3, MAF5, UFC and CO, Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development


This is E3 ubiquitin-protein ligase BRE1-like 2 protein, from Mouse-ear cress, contains 900 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1, H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me, It thereby plays a central role in histone code and gene regulation, Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6


This is Protein SENSITIVE TO PROTON RHIZOTOXICITY 1 protein, from Mouse-ear cress, contains 499 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Probable transcription factor, Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+), Required for the expression of genes in response to acidic stress (e,g, ALMT1 and MATE), and Al-activated citrate exudation


This is Zinc finger CCCH domain-containing protein 15 protein, from Mouse-ear cress, contains 308 amino acids, has 2 C3H1-type Zinc finger.

Functions probably as a transcriptional factor that activates genes involved in secondary cell wall biosynthesis (PubMed:25228083, PubMed:25732536), Functions redudantly with C3H14 to regulate secondary cell wall formation (PubMed:25732536), C3H14 and C3H15 have overlapping roles in the regulation of secondary cell wall formation and anther development (PubMed:25732536), C3H14 may contribute more to secondary cell wall thickening while C3H15 could be more important in anther development (PubMed:25732536), May regulate at both the transcriptional and post-transcriptional levels the expression of many genes involved in various biological processes, particularly those associated with cell wall metabolism and pollen development (PubMed:25732536), Involved in the regulation of callose metabolism in male meiocytes, in integrity of newly formed microspores, and promotes male fertility (PubMed:24567187), May be involved in the regulation of the callose synthesis genes CALS5 and CALS12, the potential degradation of callose walls-related genes A6 and MYB80, as well as other putative beta-1,3-glucanase genes (PubMed:24567187), Negatively regulates cell elongation by inhibiting brassinosteroid (BR) signaling (PubMed:35139225), Functions downstream of the BRI1 receptor as a negative regulator in the BR pathway (PubMed:35139225)


This is Zinc finger protein GIS3 protein, from Mouse-ear cress, contains 244 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin, Acts upstream of GIS, GIS2, ZFP8, and the trichome initiation factors GL1 and GL3, Binds the promoter region of GIS and GIS2, which may be direct targets of GIS3


This is Protein indeterminate-domain 14 protein, from Mouse-ear cress, contains 419 amino acids, has 3 C2H2-type Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

CCHC-type 2; atypical

Transcription factor regulating starch metabolism by binding directly to the promoter of QQS (PubMed:21556057), The IDD14beta isoform attenuates the transcription factor activity by competitively forming heterodimers with reduced DNA-binding capacity(PubMed:21556057), Regulates lateral organ morphogenesis and gravitropic responses (PubMed:24039602), Has a redundant role with IDD16 in directing leaf and floral organ morphogenesis (PubMed:24039602), Involved in the establishment of auxin gradients through the regulation of auxin biosynthesis and transport (PubMed:24039602)


This is Mini zinc finger protein 1 protein, from Mouse-ear cress, contains 102 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate

Inhibits zinc finger homeodomain (ZHD) transcription factors, such as ZHD5, by interacting with them to prevent both their nuclear localization and their DNA-binding properties, Involved in integrating signals from multiple hormones by preventing the expression of genes involved in gibberellic acid (GA), auxin and brassinosteroid signaling and by promoting the expression of abscisic acid (ABA)-responsive genes, Regulates several development aspects, including photomorphogenesis, apical dominance, longevity, flower morphology and fertility, as well as root and stem elongation, Promotes the formation of ectopic shoot meristems on leaf margins


This is Nuclear intron maturase 4, mitochondrial protein, from Mouse-ear cress, contains 798 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Nuclear-encoded maturase required for splicing of group-II introns in mitochondria, Involved in NAD1 pre-mRNA processing and maturation of introns 1, 3 and 4, Necessary for mitochondrial biogenesis during early developmental stages, Essential for respiratory holocomplex I biogenesis in mitochondria

Belongs to the plant nuclear intron maturase (nMat) family


This is Peroxisome biogenesis protein 2 protein, from Mouse-ear cress, contains 333 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:17478547, PubMed:20679226, PubMed:23336935, PubMed:25214533), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (PubMed:17478547, PubMed:20679226, PubMed:23336935), PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity)


This is U11/U12 small nuclear ribonucleoprotein 31 kDa protein protein, from Mouse-ear cress, contains 261 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

RNA chaperone required for proper U12 intron splicing and for normal growth and development of plants, Mainly responsible for meristem activity, Plays a role in regulating cell division


This is E3 ubiquitin-protein ligase RING2 protein, from Mouse, contains 336 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365), H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365), May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528), Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:22325148, PubMed:16710298), PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:22325148, PubMed:16710298), E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298), Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298), Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355), Association with the chromosomal DNA is cell-cycle dependent, In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696), Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (PubMed:24980959)


This is E3 ubiquitin-protein ligase FANCL protein, from Mouse, contains 375 amino acids, has 1 RING-type Zinc finger.

RING-type

Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway, Also mediates monoubiquitination of FANCI, May stimulate the ubiquitin release from UBE2W, May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth


This is RING finger and CHY zinc finger domain-containing protein 1 protein, from Mouse, contains 261 amino acids, has 1 CHY-type Zinc finger, has 1 CTCHY-type Zinc finger, has 1 RING-type Zinc finger.

CHY-type

CTCHY-type

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (By similarity), Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (By similarity), Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:12654245), Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity)


This is Histone-lysine N-methyltransferase SMYD3 protein, from Mouse, contains 428 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Histone methyltransferase, Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation, Also methylates 'Lys-5' of histone H4, Plays an important role in transcriptional activation as a member of an RNA polymerase complex, Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family


This is DNA (cytosine-5)-methyltransferase 3-like protein, from Mouse, contains 421 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (PubMed:11719692, PubMed:15318244, PubMed:15671018, PubMed:24074865), Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:15671018), Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:15671018), Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (By similarity), Plays a key role in embryonic stem cells and germ cells (PubMed:11719692, PubMed:15318244, PubMed:24074865), In germ cells, required for the methylation of imprinted loci together with DNMT3A (PubMed:11719692), In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (PubMed:15318244), Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (PubMed:24074865), While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (PubMed:24074865), Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (PubMed:24074865), Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (PubMed:24074865)


This is E3 ubiquitin-protein ligase RNF135 protein, from Mouse, contains 417 amino acids, has 1 RING-type Zinc finger.

RING-type

E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531), Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:21147464, PubMed:28469175, PubMed:31006531), Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531), This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (PubMed:31006531), Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (By similarity), It is not involved in the innate immune response against DNA viruses (PubMed:21147464)


This is CXXC-type zinc finger protein 1 protein, from Mouse, contains 660 amino acids, has 1 PHD-type Zinc finger, has 1 CXXC-type Zinc finger.

PHD-type

CXXC-type

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG


This is PHD finger protein 19 protein, from Mouse, contains 578 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23104054, PubMed:23160351, PubMed:22438827, PubMed:23273982), Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351), Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal (PubMed:22438827), Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (By similarity)


This is E3 ubiquitin-protein ligase TRIM13 protein, from Mouse, contains 407 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD), This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins, Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, Regulates ER stress-induced autophagy, and may act as a tumor suppressor, Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway, Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation, Participates as well in T-cell receptor-mediated NF-kappa-B activation, In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B


This is Zinc finger CCHC domain-containing protein 12 protein, from Mouse, contains 402 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway, It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex, It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression


This is E3 ubiquitin-protein ligase RNF146 protein, from Mouse, contains 359 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex, Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2, Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation, Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48', May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location, Neuroprotective protein (By similarity), Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (PubMed:21602803, PubMed:21825151), Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (PubMed:21602803, PubMed:21825151), Does not affect PARP1 activation, Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (PubMed:21602803, PubMed:21825151), Promotes cell survival after gamma-irradiation, Facilitates DNA repair (By similarity)


This is E3 ubiquitin-protein ligase MGRN1 protein, from Mouse, contains 532 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, Mediates TSG101 monoubiquitination at multiple sites, Plays a role in the regulation of endosome-to-lysosome trafficking, Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production, Does not inhibit ADRB2-signaling, Does not promote MC1R ubiquitination (By similarity), Acts also as a negative regulator of hedgehog signaling (PubMed:29290584)


This is E3 ubiquitin-protein ligase RNF115 protein, from Mouse, contains 305 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes, Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4


This is Zinc finger BED domain-containing protein 3 protein, from Mouse, contains 228 amino acids, has 1 BED-type Zinc finger.

BED-type

Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (PubMed:19141611), Involved in transcription activation of Wnt target gene expression (PubMed:19141611), Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (PubMed:28992324), Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (PubMed:28992324)


This is Pygopus homolog 1 protein, from Mouse, contains 417 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Involved in signal transduction through the Wnt pathway


This is Histone acetyltransferase KAT8 protein, from Mouse, contains 458 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Histone acetyltransferase which may be involved in transcriptional activation (PubMed:31794431), May influence the function of ATM, As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (Probable), As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues, That activity is less specific than the one of the MSL complex, Can also acetylate TP53/p53 at 'Lys-120' (By similarity)


This is Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 protein, from Mouse, contains 614 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors, Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity), Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development


This is E3 ubiquitin-protein ligase RNF186 protein, from Mouse, contains 226 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress, Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis, Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens (PubMed:34623328), Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR, Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2, Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498), Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity


This is Transcription factor Sp2 protein, from Mouse, contains 612 amino acids, has 3 C2H2-type Zinc finger.

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Dystrobrevin alpha protein, from Mouse, contains 746 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Involved in synapse maturation and required for normal muscle function

Belongs to the dystrophin family, Dystrobrevin subfamily


This is Carcinoembryonic antigen-related cell adhesion molecule 20 protein, from Mouse, contains 577 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response

Belongs to the immunoglobulin superfamily, CEA family


This is E3 ubiquitin-protein ligase RNF128 protein, from Mouse, contains 428 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation, Functions as an inhibitor of cytokine gene transcription, Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production, Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse, Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity)


This is SLAM family member 8 protein, from Mouse, contains 278 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor


This is PHD finger protein 14 protein, from Mouse, contains 941 amino acids, has 4 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

PHD-type

PHD-type

Histone-binding protein (By similarity), Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity), Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (PubMed:22730381), Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (PubMed:33035772)


This is PHD finger protein 6 protein, from Mouse, contains 364 amino acids, has 2 C2HC pre-PHD-type Zinc finger, has 2 PHD-type Zinc finger.

C2HC pre-PHD-type

PHD-type

C2HC pre-PHD-type

PHD-type

Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription


This is V-type immunoglobulin domain-containing suppressor of T-cell activation protein, from Mouse, contains 308 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Immunoregulatory receptor which inhibits the T-cell response (PubMed:21383057, PubMed:24743150, PubMed:25267631), May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (PubMed:20042595), May stimulate MMP14-mediated MMP2 activation (By similarity)


This is Transmembrane and immunoglobulin domain-containing protein 1 protein, from Mouse, contains 261 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival


This is V-set and transmembrane domain-containing protein 5 protein, from Mouse, contains 199 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics, Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia, In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution, Promotes formation of unstable neuronal spines such as thin and branched types, Regulates neuronal morphogenesis and migration during cortical development in the brain


This is Large ribosomal subunit protein eL37 protein, from Mouse, contains 97 amino acids, has 1 C4-type Zinc finger.

Component of the large ribosomal subunit (PubMed:36517592), The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)

Belongs to the eukaryotic ribosomal protein eL37 family


This is Aprataxin and PNK-like factor protein, from Mouse, contains 499 amino acids, has 2 PBZ-type Zinc finger.

PBZ-type

PBZ-type

Histone chaperone involved in single-strand and double-strand DNA break repair (By similarity), Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (By similarity), Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:27875275), Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (By similarity), Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity), Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721), Also acts as a negative regulator of cell pluripotency by promoting histone exchange (PubMed:27875275), Required for the embryo implantation during the epithelial to mesenchymal transition in females (PubMed:33277378)


This is Splicing factor U2AF 35 kDa subunit protein, from Mouse, contains 239 amino acids, has 2 C3H1-type Zinc finger.

Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection, Recruits U2 snRNP to the branch point, Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity)

Belongs to the splicing factor SR family


This is Junctional adhesion molecule C protein, from Mouse, contains 310 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis


This is PHD finger protein 10 protein, from Mouse, contains 497 amino acids, has 1 PHD-type 1; degenerate Zinc finger, has 1 PHD-type 2; degenerate Zinc finger.

PHD-type 1; degenerate

PHD-type 2; degenerate

Involved in transcription activity regulation by chromatin remodeling, Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors, During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth


This is Inhibitor of growth protein 5 protein, from Mouse, contains 240 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4, Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity, Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator, Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner


This is Izumo sperm-egg fusion protein 1 protein, from Mouse, contains 397 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg (PubMed:15759005, PubMed:24739963, PubMed:27309808), The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:15759005, PubMed:24739963, PubMed:27309808), The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:15759005, PubMed:24739963, PubMed:27309808)


This is E3 ubiquitin-protein ligase RNF125 protein, from Mouse, contains 233 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53, Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation, Mediates ubiquitination and subsequent degradation of p53/TP53, Mediates ubiquitination and subsequent degradation of JAK1, Acts as a positive regulator of T-cell activation


This is E3 ubiquitin-protein ligase Zswim2 protein, from Mouse, contains 631 amino acids, has 1 SWIM-type Zinc finger, has 2 RING-type Zinc finger, has 1 ZZ-type Zinc finger.

SWIM-type

RING-type

ZZ-type

RING-type

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis, Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes


This is E3 ubiquitin-protein ligase ZNRF4 protein, from Mouse, contains 327 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (By similarity), Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (By similarity), Could have a role in spermatogenesis (PubMed:10191088)


This is Abscission/NoCut checkpoint regulator protein, from Mouse, contains 389 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage, Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis, Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity)

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome


This is E3 ubiquitin-protein ligase MARCHF8 protein, from Mouse, contains 286 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:16785530, PubMed:35503863), Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins, Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation, Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway, Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination, Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863)


This is A-kinase anchor protein 8 protein, from Mouse, contains 687 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II), Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis, Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (By similarity), Specifically involved in recruitment of CAPD2 to, and condensation of maternal but not paternal chromosomes (PubMed:12082153), May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107), Required for cell cycle G2/M transition and histone deacetylation during mitosis, In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L, Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation, May be involved in regulation of DNA replication by acting as scaffold for MCM2, Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation, In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation, May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells, May act as a carrier protein of GJA1 for its transport to the nucleus, May play a repressive role in the regulation of rDNA transcription, Preferentially binds GC-rich DNA in vitro, In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (By similarity), Involved in modulation of Toll-like receptor signaling, Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (PubMed:19531803)


This is 5'-3' exoribonuclease 2 protein, from Mouse, contains 951 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Possesses 5'->3' exoribonuclease activity, May promote the termination of transcription by RNA polymerase II, During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase, The processive degradation of this 3' fragment by this protein may promote termination of transcription, Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity)

Belongs to the 5'-3' exonuclease family, XRN2/RAT1 subfamily


This is E3 ubiquitin-protein ligase RNF6 protein, from Mouse, contains 667 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation, Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover, Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity, May also bind DNA and function as a transcriptional regulator


This is Matrix remodeling-associated protein 8 protein, from Mouse, contains 442 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220), Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072), Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581), Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220), Stimulates formation of primary cilia in chondrocytes (PubMed:29702220), Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220), Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity), Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity), Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity), May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461)


This is Forkhead box protein P4 protein, from Mouse, contains 795 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional repressor that represses lung-specific expression


This is E3 ubiquitin-protein ligase synoviolin protein, from Mouse, contains 612 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12975321, PubMed:15611074), Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12975321, PubMed:15611074), Also promotes the degradation of normal but naturally short-lived proteins such as SGK, Protects cells from ER stress-induced apoptosis, Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702), Required for embryogenesis (PubMed:15611074), Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (PubMed:21911472), During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (PubMed:29907570)


This is Transmembrane protein 25 protein, from Mouse, contains 365 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

In neurons, modulates the degradation of NMDA receptor GRIN2B subunit, Plays a role in the regulation of neuronal excitability


This is AN1-type zinc finger protein 6 protein, from Mouse, contains 223 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger.

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis, Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity), Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6, In vitro involved in PEX5 export from the cytosol to peroxisomes


This is Transcriptional activator protein protein, from TYLCCNV, contains 134 amino acids, has 1  Zinc finger.

Strong activator of the late viral genes promoters, Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs, TrAP suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway, Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense, Determines pathogenicity (By similarity)

Belongs to the geminiviridae transcriptional activator protein family


This is Programmed cell death 1 ligand 1 protein, from Mouse, contains 290 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:12218188, PubMed:27281199), The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:12218188), The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:12218188)

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Dystrophin-related protein 2 protein, from Rat, contains 957 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells, Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane, Possibly involved in membrane-cytoskeleton interactions of the central nervous system


This is Cell surface glycoprotein MUC18 protein, from Rat, contains 648 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue, Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread, Could be an adhesion molecule active in neural crest cells during embryonic development, Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity)


This is Krueppel-like factor 15 protein, from Mouse, contains 415 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity), Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart, Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis, Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity, Is a negative regulator of TP53 acetylation, Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation (By similarity), Involved in podocyte differentiation


This is Zinc finger protein 384 protein, from Rat, contains 579 amino acids, has 8 C2H2-type Zinc finger.

Transcription factor that binds the consensus DNA sequence [GC]AAAAA, Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Sharpin protein, from Rat, contains 381 amino acids, has 1 RanBP2-type Zinc finger.

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation, LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways, Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation, LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex, The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria, LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin, The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation, Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis


This is DNA-binding protein SMUBP-2 protein, from Rat, contains 988 amino acids, has 1 AN1-type Zinc finger.

5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (By similarity), Specific to 5'-phosphorylated single-stranded guanine-rich sequences (By similarity), May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (By similarity), May play a role in regulation of transcription (PubMed:11106437), Interacts with tRNA-Tyr (By similarity)

Belongs to the DNA2/NAM7 helicase family


This is Tripartite motif-containing protein 54 protein, from Mouse, contains 366 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

May bind and stabilize microtubules during myotubes formation


This is Zinc finger protein 704 protein, from Mouse, contains 566 amino acids, has 1 C2H2-type Zinc finger.

Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer


This is Interleukin-1 receptor-like 2 protein, from Mouse, contains 574 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for interleukin-36 (IL36A, IL36B and IL36G), After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways, The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system, Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway

Belongs to the interleukin-1 receptor family


This is E3 ubiquitin-protein ligase makorin-2 protein, from Mouse, contains 416 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:28378844), Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappa-B transactivation and negatively regulating inflammatory responses (PubMed:28378844), Plays a role in the regulation of spermiation and in male fertility (PubMed:28008940)


This is Nuclear protein localization protein 4 homolog protein, from Rat, contains 608 amino acids, has 1 RanBP2-type Zinc finger.

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome, The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (PubMed:10811609, PubMed:11740563, PubMed:11781570, PubMed:12411482, PubMed:12644454, PubMed:14636562), Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity)


This is Cell surface glycoprotein CD200 receptor 1 protein, from Mouse, contains 326 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein, Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli


This is Cell surface glycoprotein CD200 receptor 1 protein, from Rat, contains 327 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein, Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity)


This is Inhibitor of growth protein 2 protein, from Mouse, contains 281 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53, Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones, ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity)


This is Hyaluronan and proteoglycan link protein 2 protein, from Mouse, contains 341 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Mediates a firm binding of versican V2 to hyaluronic acid, May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization, Binds to hyaluronic acid

Secreted, extracellular space, extracellular matrix