This is Pre-mRNA-splicing factor SLU7 protein, from Mouse, contains 585 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for pre-mRNA splicing as component of the spliceosome, Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron, Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region, May be involved in the activation of proximal AG, Probably also involved in alternative splicing regulation


This is Sodium channel subunit beta-3 protein, from Mouse, contains 215 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Modulates channel gating kinetics, Causes unique persistent sodium currents, Inactivates the sodium channel opening more slowly than the subunit beta-1, Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity)

Belongs to the sodium channel auxiliary subunit SCN3B (TC 8,A,17) family


This is SLAM family member 7 protein, from Mouse, contains 333 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922), Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (By similarity), Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B, In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation, However, in the absence of SH2D1B, inhibits NK cell function, Acts also inhibitory in T-cells (PubMed:19151721), May play a role in lymphocyte adhesion (By similarity), In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (By similarity)


This is Zinc finger and BTB domain-containing protein 46 protein, from Mouse, contains 600 amino acids, has 2 C2H2-type Zinc finger.

Functions as a transcriptional repressor for PRDM1


This is RUN and FYVE domain-containing protein 1 protein, from Mouse, contains 712 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking


This is Probable ribonuclease ZC3H12D protein, from Mouse, contains 533 amino acids, has 1 C3H1-type Zinc finger.

May regulate cell growth likely by suppressing RB1 phosphorylation (By similarity), May function as RNase and regulate the levels of target RNA species (Potential), In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560), Serve as a tumor suppressor in certain leukemia cells (By similarity), Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (By similarity)


This is Kazal-type serine protease inhibitor domain-containing protein 1 protein, from Mouse, contains 313 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Involved in the proliferation of osteoblasts during bone formation and bone regeneration, Promotes matrix assembly

Secreted, extracellular space, extracellular matrix


This is E3 ubiquitin-protein ligase RNF144B protein, from Mouse, contains 301 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation, Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism, However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By similarity)

Belongs to the RBR family, RNF144 subfamily


This is Zinc finger protein 410 protein, from Mouse, contains 478 amino acids, has 5 C2H2-type Zinc finger.

Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416), Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416), May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (By similarity), May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (By similarity), However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (By similarity)


This is RING finger protein unkempt homolog protein, from Mouse, contains 810 amino acids, has 5 C3H1-type Zinc finger, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development, Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system, Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif, Associated with polysomes (PubMed:25737280)


This is Serine/arginine-rich splicing factor 7 protein, from Mouse, contains 267 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for pre-mRNA splicing, Represses the splicing of MAPT/Tau exon 10, May function as export adapter involved in mRNA nuclear export such as of histone H2A, Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity, RNA-binding is semi-sequence specific (By similarity)

Belongs to the splicing factor SR family


This is Lethal(3)malignant brain tumor-like protein 3 protein, from Mouse, contains 883 amino acids, has 1 CCHHC-type; degenerate Zinc finger.

CCHHC-type; degenerate

Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression, It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (By similarity), Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713), Also involved in the regulation of ubiquitin-dependent degradation of methylated DNMT1 and E2F1 (By similarity), Required for normal maturation of myeloid progenitor cells


This is Cell adhesion molecule 2 protein, from Mouse, contains 435 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation, Important for synapse organization, providing regulated trans-synaptic adhesion, Preferentially binds to oligodendrocytes (By similarity)


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 3 protein, from Mouse, contains 626 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Promotes neurite outgrowth in hippocampal neurons


This is Pleckstrin homology domain-containing family M member 3 protein, from Mouse, contains 761 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in skeletal muscle differentiation (PubMed:19028694), May act as a scaffold protein for AKT1 during muscle differentiation (PubMed:19028694)


This is E3 ubiquitin-protein ligase MYLIP protein, from Mouse, contains 445 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8, Activity depends on E2 enzymes of the UBE2D family, Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth, Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR


This is Cilium assembly protein DZIP1 protein, from Mouse, contains 852 amino acids, has 1 C2H2-type Zinc finger.

Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:23955340, PubMed:25860027, PubMed:31118289, PubMed:32051257), At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (PubMed:25860027), Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium (PubMed:27979967), It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (PubMed:23955340), Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (PubMed:23955340), It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum (PubMed:32051257), Also indirectly involved in heart development through its function in ciliogenesis (PubMed:31118289)

Cytoplasm, cytoskeleton, cilium basal body

Belongs to the DZIP C2H2-type zinc-finger protein family


This is Transcriptional regulator Kaiso protein, from Mouse, contains 671 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator with bimodal DNA-binding specificity, Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS), May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters, Contributes to the repression of target genes of the Wnt signaling pathway, May also activate transcription of a subset of target genes by the recruitment of CTNND2, Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (By similarity)


This is Methionine aminopeptidase 1 protein, from Mouse, contains 386 amino acids, has 1 C6H2-type Zinc finger.

Cotranslationally removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

Belongs to the peptidase M24A family, Methionine aminopeptidase type 1 subfamily


This is Zinc finger CCHC domain-containing protein 3 protein, from Mouse, contains 400 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424), Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424), Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (By similarity), Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (By similarity), Promotes sensing of viral RNA by RIG-I-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (By similarity)


This is E3 ubiquitin-protein ligase NHLRC1 protein, from Mouse, contains 401 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways, In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS), Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation, Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation, Also promotes proteasome-independent protein degradation through the macroautophagy pathway


This is Kin of IRRE-like protein 3 protein, from Mouse, contains 778 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Synaptic adhesion molecule required for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286), Required for formation of target-specific synapses at hippocampal mossy fiber synapses, Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons, Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation (PubMed:26575286), Required for the coalescence of vomeronasal sensory neuron axons (PubMed:23637329), May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells (PubMed:12665856)

Belongs to the immunoglobulin superfamily


This is CCR4-NOT transcription complex subunit 4 protein, from Mouse, contains 575 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 C3H1-type Zinc finger.

RING-type; degenerate

Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins, Involved in activation of the JAK/STAT pathway, Catalyzes ubiquitination of methylated RBM15, Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA, As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy


This is SET and MYND domain-containing protein 4 protein, from Mouse, contains 799 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a critical role in cardiac development (By similarity), Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is RAS guanyl-releasing protein 4 protein, from Mouse, contains 673 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP, May function in mast cells differentiation


This is Polycomb group RING finger protein 3 protein, from Mouse, contains 241 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:28596365), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity), Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365)


This is Tripartite motif-containing protein 14 protein, from Mouse, contains 440 amino acids, has 1 B box-type Zinc finger.

B box-type

Plays an essential role in the innate immune defense against viruses and bacteria, Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways, Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593), Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression, Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (PubMed:14592421)


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 5 protein, from Mouse, contains 719 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Promotes neurite outgrowth in hippocampal neurons (By similarity)


This is Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 protein, from Mouse, contains 857 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ARF1 and, to a lesser extent, ARF5, Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system (By similarity)

Belongs to the centaurin gamma-like family


This is Zinc finger and BTB domain-containing protein 49 protein, from Mouse, contains 756 amino acids, has 7 C2H2-type Zinc finger.

Transcription factor, Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription

Belongs to the krueppel C2H2-type zinc-finger protein family


This is FYVE, RhoGEF and PH domain-containing protein 2 protein, from Mouse, contains 655 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Activates JNK1 via CDC42 but not RAC1, Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate


This is Serine/threonine-protein kinase D2 protein, from Mouse, contains 875 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:17226786, PubMed:20819079), May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (PubMed:17226786), In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-718 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (By similarity), In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (By similarity), Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation, During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (PubMed:20819079), In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (By similarity), During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (By similarity), In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (By similarity), Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (By similarity), In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (By similarity), Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (By similarity)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is SH3 and cysteine-rich domain-containing protein 3 protein, from Mouse, contains 360 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization (PubMed:23818578, PubMed:27621462, PubMed:29467163), Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction (PubMed:23818578), Probably functions via its effects on muscle calcium channels, Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane (PubMed:27621462), Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (PubMed:25548159, PubMed:27621462, PubMed:29467163), Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593)


This is Zinc finger protein 322 protein, from Mouse, contains 410 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger, has 1 C2H2-type 10; degenerate Zinc finger.

C2H2-type 9; degenerate

C2H2-type 10; degenerate

Transcriptional activator, Important for maintenance of pluripotency in embryonic stem cells, Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes, Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly, Promotes inhibition of MAPK signaling during embryonic stem cell differentiation


This is PR domain zinc finger protein 8 protein, from Mouse, contains 688 amino acids, has 3 C2H2-type Zinc finger.

Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955), Histone methyltransferase activity has not been confirmed in other species, Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955), Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184), In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183)


This is E3 ubiquitin-protein ligase SH3RF2 protein, from Mouse, contains 735 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity, Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation, Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation, Inhibits PPP1CA phosphatase activity (By similarity)


This is E3 ubiquitin-protein ligase TRIM35 protein, from Mouse, contains 501 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response (By similarity) (PubMed:32562145), Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway, Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2, Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling, Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway, Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (By similarity)


This is Leucine-rich repeat-containing protein 4C protein, from Mouse, contains 640 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May promote neurite outgrowth of developing thalamic neurons


This is Zinc fingers and homeoboxes protein 2 protein, from Mouse, contains 836 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor (PubMed:19515908), Represses the promoter activity of the CDC25C gene stimulated by NFYA (By similarity), May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (PubMed:30146259), In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (PubMed:19515908)


This is Inhibitor of growth protein 4 protein, from Mouse, contains 249 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4, Through chromatin acetylation it may function in DNA replication, May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation, Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA, May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC, Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity), Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890)


This is E3 ubiquitin-protein ligase TRIM47 protein, from Mouse, contains 641 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD


This is Zinc fingers and homeoboxes protein 3 protein, from Mouse, contains 951 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor, Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation, Is a regulator of podocyte gene expression during primary glomerula disease, Binds to promoter DNA


This is Zinc finger MYND domain-containing protein 15 protein, from Mouse, contains 736 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs), May regulate haploid genes important for spermiogenesis


This is E3 ubiquitin-protein ligase SH3RF3 protein, from Mouse, contains 878 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity


This is Protein mono-ADP-ribosyltransferase TIPARP protein, from Mouse, contains 657 amino acids, has 1 C3H1-type Zinc finger.

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity), Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable)


This is Zinc finger protein Eos protein, from Mouse, contains 586 amino acids, has 6 C2H2-type Zinc finger.

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence, Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2, May be involved in the development of central and peripheral nervous systems, Essential for the inhibitory function of regulatory T-cells (Treg), Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (PubMed:19696312)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Ubiquitin carboxyl-terminal hydrolase 44 protein, from Mouse, contains 711 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset (PubMed:23187126), Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C), Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C, Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint, Promotes also the deubiquitination of histone H2A and H2B, Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (By similarity), Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (PubMed:23187126), Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability, Plays also a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (By similarity)

Belongs to the peptidase C19 family, USP44 subfamily


This is E3 SUMO-protein ligase PIAS2 protein, from Mouse, contains 621 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway, The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied, However, it seems to be mostly involved in gene silencing, Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity, Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation, Isoform PIASx-alpha promotes PARK7 sumoylation, Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha (By similarity), Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity)


This is Ubiquitin carboxyl-terminal hydrolase 20 protein, from Mouse, contains 916 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis, Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination, Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization, Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1, Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2), Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2, Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2, This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins, Deubiquitinates DIO2, thereby regulating thyroid hormone regulation, Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity, Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability, Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol

Belongs to the peptidase C19 family, USP20/USP33 subfamily


This is Zinc finger protein 57 protein, from Mouse, contains 421 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 3 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 5; degenerate

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation, Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:15070898, PubMed:18854139, PubMed:23059534, PubMed:30602440), Acts together with ZNF445, but ZFP57 plays the predominant role in imprinting maintenance, In contrast, in humans, ZNF445 seems to be the major factor early embryonic imprinting maintenance (PubMed:30602440), Required for the establishment of maternal methylation imprints at SNRPN locus, Acts as a transcriptional repressor in Schwann cells, Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (PubMed:15070898, PubMed:18854139, PubMed:23059534)


This is E3 ubiquitin-protein ligase TRIM9 protein, from Mouse, contains 817 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation, May play a role in regulation of neuronal functions, May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation


This is RNA-binding protein 4 protein, from Mouse, contains 361 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation, Modulates alternative 5'-splice site and exon selection, Acts as a muscle cell differentiation-promoting factor, Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation, Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin, Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs, Required for the translational activation of PER1 mRNA in response to circadian clock, Binds directly to the 3'-UTR of the PER1 mRNA, Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation, Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress, Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions, Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs, Associates with miRNAs during muscle cell differentiation, Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro


This is Ubiquitin thioesterase OTU1 protein, from Mouse, contains 343 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore, Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel, Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains, Also able to hydrolyze 'Lys-11'-linked ubiquitin chains, Cleaves both polyubiquitin and di-ubiquitin, May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes, May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation


This is E3 ubiquitin-protein ligase RNF170 protein, from Mouse, contains 286 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway, Also involved in ITPR1 turnover in resting cells


This is Immunoglobulin-like domain-containing receptor 1 protein, from Mouse, contains 537 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027), Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs (PubMed:25217574), Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine (PubMed:23863714), In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060)

Belongs to the immunoglobulin superfamily, LISCH7 family


This is Transcription factor E4F1 protein, from Mouse, contains 783 amino acids, has 7 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 3; degenerate

C2H2-type 9; degenerate

May function as a transcriptional repressor, May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53, Functions in cell survival and proliferation through control of the cell cycle, Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription


This is RING1 and YY1-binding protein protein, from Mouse, contains 228 amino acids, has 1 RanBP2-type Zinc finger.

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:22325148, PubMed:28596365), Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365), May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (PubMed:22325148, PubMed:28596365), Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity), May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:17874297), May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity), May bind to DNA (PubMed:19170609), May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911)


This is F-box only protein 43 protein, from Mouse, contains 640 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization, Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase, Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:16456547), Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis (PubMed:28723571)


This is Zinc finger protein 263 protein, from Mouse, contains 680 amino acids, has 9 C2H2-type Zinc finger.

Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (By similarity), Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (By similarity), Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (By similarity)


This is Krueppel-like factor 17 protein, from Mouse, contains 341 amino acids, has 3 C2H2-type Zinc finger.

Transcription repressor that binds to the promoter of target genes and prevents their expression, Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer, Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression, May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is ATPase WRNIP1 protein, from Rat, contains 660 amino acids, has 1 UBZ4-type Zinc finger.

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis, In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased, Also plays a role in the innate immune defense against viruses, Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination, In turn, RIGI transmits the signal through mitochondrial MAVS

Belongs to the AAA ATPase family, RarA/MGS1/WRNIP1 subfamily


This is Calcium-binding and coiled-coil domain-containing protein 1 protein, from Mouse, contains 691 amino acids, has 1 UBZ1-type Zinc finger.

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR), Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2, During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1, Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway, Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1, Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions, In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781)


This is E3 ubiquitin-protein ligase TRIM32 protein, from Mouse, contains 655 amino acids, has 1 RING-type Zinc finger, has 1 B box-type; atypical Zinc finger.

RING-type

B box-type; atypical

Has an E3 ubiquitin ligase activity (PubMed:14578165, PubMed:16816390), Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (By similarity), May ubiquitinate BBS2 (By similarity), Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (PubMed:14578165, PubMed:16816390)Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (By similarity)


This is Histone acetyltransferase KAT5 protein, from Mouse, contains 513 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:28694333, PubMed:30297459, PubMed:32542325), Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (By similarity), The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17728759), The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:30297459), Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (By similarity), The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A,Z/H2AZ1 at MYC target genes (PubMed:32542325), The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (PubMed:28694333), Component of a SWR1-like complex that specifically mediates the removal of histone H2A,Z/H2AZ1 from the nucleosome (By similarity), Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:22539723, PubMed:24835996, PubMed:31294688), Directly acetylates and activates ATM (By similarity), Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (By similarity), Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (By similarity), Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:24835996), Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311), Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (By similarity), Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (PubMed:31294688), Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:22539723), Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (By similarity), Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:29765047), Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (By similarity), Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation and 2-hydroxyisobutyrylation, respectively (By similarity), Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (By similarity), Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (By similarity), Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (By similarity), Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (By similarity), Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (By similarity)


This is Zinc finger CCCH domain-containing protein 3 protein, from Mouse, contains 950 amino acids, has 5 C3H1-type Zinc finger.

Required for the export of polyadenylated mRNAs from the nucleus (By similarity), Enhances ACVR1B-induced SMAD-dependent transcription, Binds to single-stranded DNA but not to double-stranded DNA in vitro, Involved in RNA cleavage (PubMed:16115198)


This is Transcriptional adapter 2-alpha protein, from Mouse, contains 443 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity), Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity), Binds double-stranded DNA (PubMed:16299514), Binds dinucleosomes, probably at the linker region between neighboring nucleosomes (PubMed:16299514), Plays a role in chromatin remodeling (By similarity), May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (By similarity), May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (By similarity)


This is Transcriptional repressor p66 alpha protein, from Mouse, contains 629 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional repressor, Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin, Enhances MBD2-mediated repression, Efficient repression requires the presence of GATAD2B


This is N-acetyltransferase ESCO2 protein, from Mouse, contains 592 amino acids, has 1 CCHH-type Zinc finger.

CCHH-type

Acetyltransferase required for the establishment of sister chromatid cohesion, Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together, In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase, Acetylates the cohesin component SMC3

Belongs to the acetyltransferase family, ECO subfamily


This is Lysine-specific histone demethylase 1B protein, from Mouse, contains 826 amino acids, has 1 CW-type Zinc finger.

CW-type

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor, Required for de novo DNA methylation of a subset of imprinted genes during oogenesis, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Demethylates both mono- and di-methylated 'Lys-4' of histone H3, Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (PubMed:19407342, PubMed:19727073), Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (By similarity)

Belongs to the flavin monoamine oxidase family


This is E3 ubiquitin-protein ligase RFWD3 protein, from Mouse, contains 774 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage, Plays a key role in RPA-mediated DNA damage signaling and repair, Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination, Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint, May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome, In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53


This is E3 ubiquitin-protein ligase rififylin protein, from Rat, contains 362 amino acids, has 1 FYVE-type Zinc finger, has 1 RING-type Zinc finger.

FYVE-type

RING-type

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins, Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex, Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors, Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation, Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation, Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN, May also play a role in endocytic recycling


This is Transcription factor Ovo-like 2 protein, from Mouse, contains 274 amino acids, has 4 C2H2-type Zinc finger.

Zinc-finger transcription repressor factor (PubMed:15225875, PubMed:23319585, PubMed:36228616), Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (PubMed:24735878, PubMed:24735879), Positively regulates neuronal differentiation (PubMed:16423343, PubMed:23319585), Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (By similarity), Important for the correct development of primordial germ cells in embryos (PubMed:28059165), Plays dual functions in thermogenesis and adipogenesis to maintain energy balance, Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes, In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (PubMed:36228616)


This is E3 ubiquitin-protein ligase NEURL3 protein, from Mouse, contains 254 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:15936721, PubMed:35792897), Seems to utilize UBE2E1, Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897)


This is Protein disulfide-isomerase LQY1, chloroplastic protein, from Mouse-ear cress, contains 154 amino acids, has 1 CR-type Zinc finger.

CR-type

Protein disulfide-isomerase probably involved upon formation of a complex with HHL1 in maintaining photosystem II (PSII) activity under high light by regulating repair and reassembly of PSII complexes


This is Lysine-specific demethylase JMJ14 protein, from Mouse-ear cress, contains 954 amino acids, has 1 C5HC2 Zinc finger.

Transcriptional repressor (PubMed:25578968), Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a higher activity for H3K4me3 and H3K4me2 than H3K4me1 (PubMed:29233856), No activity on H3K9me3/2, H3K36me3/2 and H3K27me3/2 (PubMed:29233856), Function as a nocturne 'eraser' to counteract the diurnal 'writer' methylase activity of ATXR3/SDG2 thus orchestrating the circadian rythm of histone modifications (e,g, H3K4me3) and modulating the rythmic expression of diurnal target genes; this mechanism relies also on the circadian clock oscillators CCA1 and LHY (PubMed:31429787), Involved in a negative regulation of root meristem growth upon suboptimal root growth conditions (PubMed:31826870), Represses FT and TSF expression to inhibit the floral transition, Binds around the transcription start site of the FT locus, Involved in the DRM2-mediated maintenance of DNA methylation, but not required for the de novo DNA methylation, Required for demethylating histone H3K4me3 at the target of RNA silencing, Counteracts the DNA methylation of expressed transgenes; specific attenuation of transgene DNA methylation enhances the production of aberrant RNAs (e,g, uncapped and antisense) that readily induce systemic RDR6-dependent post-transcriptional transgene silencing (PTGS) spreading (PubMed:33986281), Together with NAC051/NAC052 and NAC050, regulates gene expression and flowering time, probably by the promotion of RNA-mediated gene silencing (PubMed:25578968), Together with JMJ16 and JMJ17, required for plant growth and development (PubMed:31038749), Promotes local and systemic immunity (especially toward the bacterial pathogen Pseudomonas syringae Pst DC3000 avrRpt2) by regulating positively pathogen-induced H3K4me3 enrichment and expression of defense genes involved in salicylic acid (SA)- and pipecolic acid (Pip)-mediated defense pathways (e,g, PR1, FMO1, ALD1 and SARD4) (PubMed:31622519)

Belongs to the JARID1 histone demethylase family


This is E3 ubiquitin-protein ligase RMA3 protein, from Mouse-ear cress, contains 243 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Axial regulator YABBY 5 protein, from Mouse-ear cress, contains 164 amino acids, has 1 C4-type Zinc finger.

Promotes adaxial cell identity, Regulates the initiation of embryonic shoot apical meristem (SAM) development


This is Chaperone protein dnaJ GFA2, mitochondrial protein, from Mouse-ear cress, contains 456 amino acids, has 1 CR-type Zinc finger.

CR-type

Chaperone that may play a role in mitochondrial protein folding, Involved in female gametophyte development, Required for cell death of the synergid cells during fertilization process, and fusion of the polar nuclei during megagametogenesis


This is E3 ubiquitin-protein ligase SGR9, amyloplastic protein, from Mouse-ear cress, contains 283 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Modulates amyloplast dynamics and sedimentation in statocytes during inflorescence, hypocotyl and root gravitropism, probably by regulating amyloplast interaction with actin filaments (AFs) in endodermal cells


This is Histone deacetylase 15 protein, from Mouse-ear cress, contains 552 amino acids, has 1 RanBP2-type Zinc finger.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:23548744), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23548744), Histone deacetylases act via the formation of large multiprotein complexes (Probable), Represses chlorophyll biosynthesis and photosynthesis in the dark (PubMed:23548744), Is recruited by PIF3 to the promoters of chlorophyll biosynthetic and photosynthetic genes, and represses their transcription by histone deacetylation (PubMed:23548744), Involved in the repression of hypocotyl cell elongation to promote photomorphogenesis (PubMed:31061103), Is recruited by HY5 to the promoters of a subset of cell wall organization and auxin signaling-related genes, and represses gene expression by decreasing the levels of histone H4 acetylation in a light-dependent manner (PubMed:31061103), Promotes abscisic acid (ABA) signaling (PubMed:30979883), Is recruited by MYB96 to the promoters of a subset of Rho GTPase (ROP) genes, which repress ABA signaling at the early stages of signal transduction (PubMed:30979883), Represses ROP expression by removing acetyl groups of histone H3 and H4 from the cognate regions, particularly in the presence of ABA (PubMed:30979883), Represses the plant response to elevated ambient temperature by directly repressing warm temperature-responsive genes (PubMed:31400169)

Belongs to the histone deacetylase family, HD type 2 subfamily


This is Squamosa promoter-binding-like protein 8 protein, from Mouse-ear cress, contains 333 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3', Binds specifically to the 5'-GTAC-3' core sequence, Involved in development and floral organogenesis, Required for ovule differentiation, pollen production, filament elongation, seed formation and siliques elongation, Also seems to play a role in the formation of trichomes on sepals, May positively modulate gibberellin (GA) signaling in flower


This is GATA transcription factor 24 protein, from Mouse-ear cress, contains 297 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters

Belongs to the type IV zinc-finger family, Class C subfamily


This is Protein indeterminate-domain 4, chloroplastic protein, from Mouse-ear cress, contains 516 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor that may act a transcriptional activator of nuclear-encoded photosynthetic gene expression (Probable), Binds DNA via its zinc fingers (PubMed:24821766), Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766)


This is E3 SUMO-protein ligase MMS21 protein, from Mouse-ear cress, contains 249 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

E3 SUMO-protein ligase that modulates cell cycle progression and functions as a repressor of endocycle onset in meristems, May function downstream of the meristem patterning transcription factors PLETHORA 1 and 2 (PLT1 and PLT2) in root meristem development, Modulates the expression of the mitotic cyclins CYCB1-1 and CYCB1-2 and cyclin-dependent kinases CDKB1-1 and CDKB2-1 in root meristem, Involved in cytokinin signaling in root development


This is Protein ULTRAPETALA 1 protein, from Mouse-ear cress, contains 237 amino acids, has 1 CW-type Zinc finger.

CW-type

Putative transcription factor that acts as a key negative regulator of cell accumulation in shoot and floral meristems, Negatively regulates the size of the WUSCHEL (WUS)-expressing organizing center in inflorescence meristems, May act by down-regulating expression of WUS, Acts as an antirepressor that counteracts EMF1 action through modulation of trimethylated 'Lys-4' on histone H3 (H3K4me3) marks on target gene loci (including genes involved in salt stress response and flower development) (PubMed:23632855), Collaboratively with RBL and CYP40/SQN, influences floral meristem (FM) determinacy in an AGAMOUS and SUPERMAN-dependent manner, thus contributing to the floral developmental homeostasis (PubMed:18441215)


This is GATA transcription factor 28 protein, from Mouse-ear cress, contains 302 amino acids, has 1 GATA-type Zinc finger.

GATA-type


This is Lysine-specific demethylase JMJ28 protein, from Mouse-ear cress, contains 927 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

May function as histone H3 lysine demethylase and be involved in regulation of gene expression (By similarity), Regulates flowering time by promoting CONSTANS (CO) and CONSTANS-LIKE genes (e,g, COL2 and COL5) expression via interaction with FBH transcription factors (FBH1, FBH2, FBH3 and FBH4) at their loci to remove H3K9me2 repressive histone marks (PubMed:33604650), Modulates also the expression of several develpmental genes such as MYB30, TFS1, AGL6 and RVE2 (PubMed:33604650)


This is Homeobox protein HAZ1 protein, from Rice, contains 792 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Transcriptional repressor involved in the regulation of gibberrelin (GA) signaling, Binds to the 5'-GATC-3' motif of HD16/EL1 promoter, Functions as a positive regulator of GA signaling by suppressing the expression of HD16/EL1, a negative regulator of GA signaling

Belongs to the PHD-associated homeobox family


This is Major histocompatibility complex class I-related gene protein protein, from Mouse, contains 341 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells, In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:20581831, PubMed:15802267), Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis, Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively, May present microbial antigens to various TRAV1-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin, Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity), During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (PubMed:12634786, PubMed:31113973), Acts as an immune sensor of cancer cell metabolome, May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity)


This is MHC class I-like protein MILL2 protein, from Mouse, contains 355 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds to heparan sulfate proteoglycans on the surface of fibroblast (NIH-3T3) cells


This is MHC class I-like protein MILL1 protein, from Mouse, contains 395 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is E3 ubiquitin-protein ligase sina protein, from Fruit fly, contains 331 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons, Also involved in external sensory organ development

Belongs to the SINA (Seven in absentia) family


This is Histone-lysine N-methyltransferase set-18 protein, from Caenorhabditis elegans, contains 507 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Histone methyltransferase (PubMed:29514099), Specifically methylates 'Lys-36' of histone H3, inducing di-methylation (PubMed:29514099), Plays a role in modulating lifespan and oxidative stress resistance, in a manner dependent upon daf-16/Forkhead box protein O and the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:29514099), Represses transcription of daf-16 isoform a, perhaps by methylating histone H3 at the daf-16 promoter, which in turn leads to recruitment of histone deacetylases and thus modulation of expression (PubMed:29514099)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family


This is Transcription factor hamlet protein, from Fruit fly, contains 990 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 6; atypical

Transcription factor that plays a crucial role in external sensory organ (ESO) that elaborates from a single precursor cell (ESOP cell), Mediates the differentiation of lineage branch that generates the internal 'ES' and 'th' cells (external sensory neuron and thecogen cells, respectively) from the IIIB cell, Its absence leads to re-specification of IIIB daughter cells into external tormagen cells (tr cells), or internal multidendritic neurons (MD cells), One of its role in the development of the ESO lineage is to modulate the activity of Notch and PAX2 signals


This is Transcriptional adapter 2B protein, from Fruit fly, contains 555 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Required for the function of some acidic activation domains, which activate transcription from a distant site, Binds double-stranded DNA, Binds dinucleosomes, probably at the linker region between neighboring nucleosomes, Plays a role in chromatin remodeling


This is Methionine aminopeptidase 1b protein, from Plasmodium falciparum (isolate 3D7), contains 517 amino acids, has 1 C6H2-type Zinc finger.

Cotranslationally removes the N-terminal methionine from nascent proteins (PubMed:16983082, PubMed:27023914), The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity), May play an important role in parasite growth during the blood asexual stage (PubMed:16983082)

Belongs to the peptidase M24A family, Methionine aminopeptidase type 1 subfamily


This is Sex determination protein fruitless protein, from Fruit fly, contains 955 amino acids, has 1 C2H2-type Zinc finger.

Probably acts as a transcriptional regulator, Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site, Vital for the development of males and females, Controls the development of the male specific abdominal muscle of Lawrence, Plays a role in male courtship behavior and sexual orientation, Enhances male-specific expression of takeout in brain-associated fat body


This is Zinc finger protein indra protein, from Fruit fly, contains 733 amino acids, has 6 C2H2-type Zinc finger.

Required for rDNA copy number maintenance and non-random sister chromatid segregation (NRSS) following unequal sister chromatid exchange (PubMed:35895823), Binds ribosomal DNA (rDNA) preferentially binding to intergenic spacers (IGS) regions on both X and Y chromosomes (PubMed:35895823), Essential for NRSS, a mechanism which contributes to the recovery and maintenance of inherently unstable rDNA copy numbers so that the integrity of the germline genome is upheld over generations and germline immortality is sustained (PubMed:35895823), May be involved in transcriptional regulation (Probable)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Nuclear hormone receptor family member nhr-80 protein, from Caenorhabditis elegans, contains 504 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor (PubMed:16839188, PubMed:35021096), Binds to regulatory elements and regulates transcription of target genes, including acyltransferase dgat-2 (PubMed:35021096), As part of a lysosome-to-nucleus retrograde lipid signaling pathway, acts as a direct nuclear receptor of oleoylethanolamide (OEA) and, acting in concert with nuclear hormone receptor nhr-49, activates the transcription of genes promoting longevity and mitochondrial beta-oxidation (PubMed:25554789, PubMed:26671266), Required to modulate expression of delta-9 fatty acid desaturases, thereby regulating lipid metabolism; in some contexts, acting in concert with nhr-49 (PubMed:16839188, PubMed:21423649, PubMed:22511885), Involved in modulation of lipid metabolism in response to the citrate-induced mitochondrial unfolded protein response (mtUPR), acting downstream of transcription factor dve-1 and ubiquitin-like protein 5 (PubMed:35021096), Plays a role in modulating mitochondrial morphology and function (PubMed:22511885), Involved in positively modulating life-span in a germline-dependent manner, acting in concert with nuclear hormone receptor daf-12 (PubMed:21423649), Plays a role in transgenerational lipid accumulation in response to a high-fat diet (PubMed:35140229)

Belongs to the nuclear hormone receptor family


This is Interferon regulatory factor 2-binding protein 1 protein, from Human, contains 584 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities, May act as an E3 ligase towards JDP2, enhancing its polyubiquitination, Represses ATF2-dependent transcriptional activation


This is E3 ubiquitin-protein ligase RNF135 protein, from Human, contains 432 amino acids, has 1 RING-type Zinc finger.

RING-type

E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531), Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531), Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531), This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable), Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531)


This is E3 ubiquitin-protein ligase SIAH1 protein, from Human, contains 282 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595, PubMed:28546513, PubMed:32430360, PubMed:33591310), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595), Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595), Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443), Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714, PubMed:33591310), It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595), Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595), Induces apoptosis in cooperation with PEG3 (By similarity), Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity), GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity), Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity), Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (PubMed:28546513, PubMed:32430360)


This is Ras guanyl-releasing protein 3 protein, from Human, contains 690 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Guanine nucleotide exchange factor (GEF) for Ras and Rap1


This is Forkhead box protein P4 protein, from Human, contains 680 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional repressor that represses lung-specific expression


This is Zinc finger protein 547 protein, from Human, contains 402 amino acids, has 10 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Kinase suppressor of Ras 1 protein, from Human, contains 923 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity), Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126), Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity), Its kinase activity is unsure (By similarity), Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity)

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family


This is V-set and transmembrane domain-containing protein 4 protein, from Human, contains 320 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors


This is Aprataxin and PNK-like factor protein, from Human, contains 511 amino acids, has 2 PBZ-type Zinc finger.

PBZ-type

PBZ-type

Histone chaperone involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:21211722, PubMed:30104678, PubMed:29905837), Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:30104678), Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:21211722, PubMed:30104678, PubMed:29905837), Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (PubMed:17353262, PubMed:17396150), Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150), Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721, PubMed:23689425), Also acts as a negative regulator of cell pluripotency by promoting histone exchange (By similarity), Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity)


This is WD repeat and FYVE domain-containing protein 1 protein, from Human, contains 410 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1, Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436)


This is Tripartite motif-containing protein 59 protein, from Human, contains 403 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:30231667), Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174), Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 (PubMed:30231667), On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway, On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex, In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation (PubMed:30231667), Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (By similarity)


This is PHD finger protein 6 protein, from Human, contains 365 amino acids, has 2 C2HC pre-PHD-type Zinc finger, has 2 PHD-type Zinc finger.

C2HC pre-PHD-type

PHD-type

C2HC pre-PHD-type

PHD-type

Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription


This is Sodium channel subunit beta-4 protein, from Human, contains 228 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Modulates channel gating kinetics, Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation, Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom

Belongs to the sodium channel auxiliary subunit SCN4B (TC 8,A,17) family


This is E3 ubiquitin-protein ligase TRIM48 protein, from Human, contains 224 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase which promotes K48-linked polyubiquitination of protein methyltransferase PRMT1, leading to PRMT1 degradation (PubMed:29186683), This suppresses methylation of the PRMT1 substrate MAP3K5/ASK1, promoting its activation and increasing MAP3K5-dependent cell death induced by oxidative stress (PubMed:29186683), TRIM48-mediated ubiquitination of PRMT1 also suppresses methylation of FOXO1 by PRMT1, leading to inhibition of FOXO1 transcriptional activity (PubMed:29186683)


This is Tripartite motif-containing protein 42 protein, from Human, contains 723 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type


This is Polyhomeotic-like protein 2 protein, from Human, contains 858 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility


This is Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 protein, from Human, contains 612 amino acids, has 1 RTR1-type Zinc finger.

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes, Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600), Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681)


This is Zinc finger CCCH domain-containing protein 3 protein, from Human, contains 948 amino acids, has 5 C3H1-type Zinc finger.

Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924), Enhances ACVR1B-induced SMAD-dependent transcription, Binds to single-stranded DNA but not to double-stranded DNA in vitro, Involved in RNA cleavage (By similarity)


This is YY1-associated factor 2 protein, from Human, contains 180 amino acids, has 1 RanBP2-type Zinc finger.

Binds to MYC and inhibits MYC-mediated transactivation, Also binds to MYCN and enhances MYCN-dependent transcriptional activation, Increases calpain 2-mediated proteolysis of YY1 in vitro, Component of the E2F6,com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling


This is Stromal membrane-associated protein 1 protein, from Human, contains 467 amino acids, has 1 C4-type Zinc finger.

GTPase activating protein that acts on ARF6, Plays a role in clathrin-dependent endocytosis, May play a role in erythropoiesis (By similarity)


This is ZZ-type zinc finger-containing protein 3 protein, from Human, contains 903 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978), Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755)


This is Zinc finger protein 440 protein, from Human, contains 595 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 10 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 5; degenerate


This is E3 ubiquitin-protein ligase TRIM22 protein, from Human, contains 498 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed:25683609, PubMed:35777501), Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed:25683609, PubMed:35777501, PubMed:36042495), Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed:25683609), Acts also by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed:36042495), Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed:26683615), Plays also a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed:36159777), Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed:35777501)


This is SET and MYND domain-containing protein 4 protein, from Human, contains 804 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a critical role in cardiac development (PubMed:30110327), Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Osteoclast-associated immunoglobulin-like receptor protein, from Human, contains 282 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation

Belongs to the leukocyte receptor complex/polymeric immunoglobulin receptor (PIR/LRC) family


This is Izumo sperm-egg fusion protein 1 protein, from Human, contains 350 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg, The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion, The ligand-receptor interaction probably does not act as a membrane 'fusogen', Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization (PubMed:36070373), FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion (PubMed:36070373)


This is E3 ubiquitin-protein ligase RNF168 protein, from Human, contains 571 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage, Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination, Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates, This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1, Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites, Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region, Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)


This is Cilium assembly protein DZIP1L protein, from Human, contains 767 amino acids, has 1 C2H2-type Zinc finger.

Involved in primary cilium formation (PubMed:19852954, PubMed:28530676), Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (PubMed:28530676)

Belongs to the DZIP C2H2-type zinc-finger protein family


This is Tissue-resident T-cell transcription regulator protein ZNF683 protein, from Human, contains 524 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites, Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells


This is Zinc finger protein 101 protein, from Human, contains 436 amino acids, has 9 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

May be involved in transcriptional regulation


This is Netrin receptor UNC5B protein, from Human, contains 945 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance, Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding, Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity), Functions as netrin receptor that negatively regulates vascular branching during angiogenesis, Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906), Mediates apoptosis by activating DAPK1, In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity)


This is Kin of IRRE-like protein 3 protein, from Human, contains 778 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Synaptic adhesion molecule required for the formation of target-specific synapses, Required for formation of target-specific synapses at hippocampal mossy fiber synapses, Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons, Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation, Required for the coalescence of vomeronasal sensory neuron axons, May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells

Belongs to the immunoglobulin superfamily