This is Receptor-transporting protein 4 protein, from Human, contains 246 amino acids, has 1 3CxxC-type Zinc finger.

Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs), Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576), Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity)


This is RING finger protein 112 protein, from Mouse, contains 654 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development, During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:21566658, PubMed:28684796), Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage (PubMed:27918959, PubMed:26792191, PubMed:26951452), Exhibits GTPase and E3 ubiquitin-protein ligase activities, Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (PubMed:26212327)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily


This is Zinc finger MYND domain-containing protein 19 protein, from Human, contains 227 amino acids, has 1 MYND-type; degenerate Zinc finger.

MYND-type; degenerate

May be involved as a regulatory molecule in GPR24/MCH-R1 signaling


This is Zinc finger protein 837 protein, from Human, contains 531 amino acids, has 8 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is THAP domain-containing protein 11 protein, from Human, contains 314 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells, Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)


This is E3 ubiquitin-protein ligase CHFR protein, from Human, contains 664 amino acids, has 1 RING-type Zinc finger, has 1 PBZ-type Zinc finger.

RING-type

PBZ-type

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons, Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus, Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome, Promotes the ubiquitination and subsequent degradation of AURKA and PLK1, Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation, May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress


This is E3 ubiquitin-protein ligase RNF125 protein, from Human, contains 232 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375), Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation (PubMed:17460044, PubMed:26471729), Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766), Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934), Acts as a positive regulator of T-cell activation (PubMed:15843525)


This is Histone-lysine N-methyltransferase PRDM9 protein, from Mouse, contains 843 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:16292313, PubMed:24095733, PubMed:27362481, PubMed:24785241, PubMed:29478809), Can also methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24785241, PubMed:27362481), Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (PubMed:24785241, PubMed:27362481), During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:22028627, PubMed:27362481, PubMed:29478809), Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (PubMed:16292313, PubMed:29478809), During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema (PubMed:27932493), EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493), In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (PubMed:25894966, PubMed:16292313), Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (PubMed:16292313), In addition performs automethylation (PubMed:28126738), Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (PubMed:27362481)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is DnaJ homolog subfamily A member 3, mitochondrial protein, from Human, contains 480 amino acids, has 1 CR-type Zinc finger.

CR-type

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix, Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation, Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis, Can modulate IFN-gamma-mediated transcriptional activity, Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway


This is E3 ubiquitin-protein ligase TRIM11 protein, from Human, contains 468 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (By similarity), Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (By similarity), May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (By similarity), May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity), Mediates MED15 ubiquitination leading to proteasomal degradation (PubMed:16904669), May contribute to the innate restriction of retroviruses (PubMed:18248090), Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090), Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090), May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090), Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (PubMed:27498865), Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (PubMed:27498865)


This is Zinc finger protein 503 protein, from Human, contains 646 amino acids, has 1 C2H2-type Zinc finger.

May function as a transcriptional repressor


This is Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 protein, from Human, contains 620 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321), Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088), Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like protein, from Human, contains 650 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860), Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860), Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860)

Belongs to the Dus family, Dus3 subfamily


This is E3 ubiquitin-protein transferase RMND5B protein, from Human, contains 393 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972), Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972), The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972)


This is Neurotrophin receptor-interacting factor homolog protein, from Human, contains 653 amino acids, has 5 C2H2-type Zinc finger.

Probable transcription repressor, Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression, The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610)


This is E3 ubiquitin-protein ligase RNF185 protein, from Human, contains 192 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693), Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036), Protects cells from ER stress-induced apoptosis (PubMed:27485036), Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521), Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS at 'Lys-173' and 'Lys-384', thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161), Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521)


This is Target of EGR1 protein 1 protein, from Human, contains 510 amino acids, has 1 C3H1-type Zinc finger.

Inhibits cell growth rate and cell cycle, Induces CDKN1A expression as well as TGF-beta expression, Mediates the inhibitory growth effect of EGR1, Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684)


This is Brevican core protein protein, from Human, contains 911 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a role in the terminally differentiating and the adult nervous system during postnatal development, Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

Belongs to the aggrecan/versican proteoglycan family


This is T-cell immunoglobulin and mucin domain-containing protein 4 protein, from Human, contains 378 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

(Microbial infection) Plays a positive role in exosome-mediated trafficking of HIV-1 virus and its entry into immune cells

Belongs to the immunoglobulin superfamily, TIM family


This is Zinc finger protein 764 protein, from Human, contains 408 amino acids, has 7 C2H2-type Zinc finger.

Zinc finger protein that functions as a cofactor for steroid hormone receptors, such as NR3C1/GR (PubMed:28139699), Directs NR3C1/GR transcriptional activity toward specific biologic pathways by changing NR3C1/GR binding and transcriptional activity on the glucocorticoid-responsive genes (PubMed:28139699)


This is Zinc finger protein 625 protein, from Human, contains 306 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 8 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 414 protein, from Human, contains 312 amino acids, has 3 C2H2-type Zinc finger.


This is Zinc finger protein 496 protein, from Human, contains 587 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 4 C2H2-type Zinc finger.

C2H2-type 1; degenerate

DNA-binding transcription factor that can both act as an activator and a repressor


This is Zinc finger BED domain-containing protein 3 protein, from Human, contains 234 amino acids, has 1 BED-type Zinc finger.

BED-type

Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (By similarity), Involved in transcription activation of Wnt target gene expression (By similarity), Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (By similarity), Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (By similarity)


This is Kin of IRRE-like protein 1 protein, from Human, contains 757 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Required for proper function of the glomerular filtration barrier, It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902), It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity)

Belongs to the immunoglobulin superfamily


This is Hypermethylated in cancer 2 protein protein, from Human, contains 615 amino acids, has 5 C2H2-type Zinc finger.

Belongs to the krueppel C2H2-type zinc-finger protein family, Hic subfamily


This is Zinc finger protein 333 protein, from Human, contains 665 amino acids, has 10 C2H2-type Zinc finger.


This is Chromosome alignment-maintaining phosphoprotein 1 protein, from Human, contains 812 amino acids, has 1 C2H2-type Zinc finger.

Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis, Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation, May recruit CENPE and CENPF to the kinetochore


This is Lethal(3)malignant brain tumor-like protein 3 protein, from Human, contains 780 amino acids, has 1 CCHHC-type; degenerate Zinc finger.

CCHHC-type; degenerate

Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483), It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483), Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1, It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713, PubMed:29691401), Required for normal maturation of myeloid progenitor cells (By similarity)


This is E3 ubiquitin-protein ligase ZFP91 protein, from Human, contains 570 amino acids, has 5 C2H2-type Zinc finger.

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK, It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway, May also play an important role in cell proliferation and/or anti-apoptosis


This is E3 ubiquitin-protein ligase RNF170 protein, from Human, contains 258 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway, Also involved in ITPR1 turnover in resting cells


This is Abscission/NoCut checkpoint regulator protein, from Human, contains 471 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage, Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis, Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome


This is Zinc finger protein 668 protein, from Human, contains 619 amino acids, has 16 C2H2-type Zinc finger.

May be involved in transcriptional regulation, May play a role in DNA repair process


This is Zinc finger CCCH domain-containing protein 10 protein, from Human, contains 434 amino acids, has 3 C3H1-type Zinc finger.

Specific regulator of miRNA biogenesis, Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA


This is Zinc finger protein 512B protein, from Human, contains 892 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 4 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 1; atypical

C2H2-type 4; atypical

C2H2-type 6; atypical


This is Fc receptor-like protein 2 protein, from Human, contains 508 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May have an regulatory role in normal and neoplastic B cell development


This is Fc receptor-like protein 1 protein, from Human, contains 429 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May function as an activating coreceptor in B-cells, May function in B-cells activation and differentiation


This is Sialic acid-binding Ig-like lectin 10 protein, from Human, contains 697 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity), The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface, In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025), Involved in negative regulation of B-cell antigen receptor signaling, The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity), In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity), In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598), Plays a role in the control of autoimmunity (By similarity), During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes, The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity)

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is E3 ubiquitin-protein ligase TRIM47 protein, from Human, contains 638 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD


This is Zinc finger protein 597 protein, from Human, contains 424 amino acids, has 7 C2H2-type Zinc finger.


This is FYVE, RhoGEF and PH domain-containing protein 4 protein, from Human, contains 766 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Plays a role in regulating the actin cytoskeleton and cell shape, Activates MAPK8 (By similarity)


This is SH3 and cysteine-rich domain-containing protein 3 protein, from Human, contains 364 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization, Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction, Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335), Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane, Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity), Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335)


This is E3 SUMO-protein ligase NSE2 protein, from Human, contains 247 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316), Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316), The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316), The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526), Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850), Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526), SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526), Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785)


This is Zinc finger protein 42 homolog protein, from Human, contains 310 amino acids, has 4 C2H2-type Zinc finger.

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency, Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST, Binds DXPas34 enhancer within the TSIX promoter, Involved in ES cell self-renewal (By similarity)


This is Zinc finger protein 488 protein, from Human, contains 340 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional repressor, Plays a role in oligodendrocyte differentiation, together with OLIG2, Mediates Notch signaling-activated formation of oligodendrocyte precursors, Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury


This is Zinc finger protein 48 protein, from Human, contains 618 amino acids, has 12 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein 578 protein, from Human, contains 590 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 10 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate


This is Zinc finger protein 641 protein, from Human, contains 438 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional activator, Activates transcriptional activities of SRE and AP-1


This is Zinc finger protein 396 protein, from Human, contains 335 amino acids, has 3 C2H2-type Zinc finger.

Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors


This is Zinc finger protein 830 protein, from Human, contains 372 amino acids, has 1 C2H2-type Zinc finger.

May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396), Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity, During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation, Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells, During the embryo preimplantation, controls different aspects of M phase, During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity)


This is Zinc finger matrin-type protein 2 protein, from Human, contains 199 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the spliceosome


This is Zinc finger protein 558 protein, from Human, contains 402 amino acids, has 9 C2H2-type Zinc finger.


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 5 protein, from Human, contains 719 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Promotes neurite outgrowth in hippocampal neurons


This is Nectin-4 protein, from Human, contains 510 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for measles virus


This is WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 protein, from Human, contains 548 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease-inhibitor that contains multiple distinct protease inhibitor domains, Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)


This is Baculoviral IAP repeat-containing protein 8 protein, from Human, contains 236 amino acids, has 1 RING-type Zinc finger.

RING-type

Protects against apoptosis mediated by BAX


This is Fc receptor-like protein 3 protein, from Human, contains 734 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation, Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366), Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases, Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936), Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275), Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion (PubMed:36070373), Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion (PubMed:36070373)


This is Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 protein, from Human, contains 875 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for the ADP ribosylation factor family (Potential), GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway

Belongs to the centaurin gamma-like family


This is WD repeat and FYVE domain-containing protein 2 protein, from Human, contains 400 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651), Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859), Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity), Participates in transferrin receptor endocytosis (PubMed:16873553)


This is Fc receptor-like protein 4 protein, from Human, contains 515 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May function as an inhibitor of the B-cell receptor signaling, May function in the B-cell-mediated immune response


This is Erythroid membrane-associated protein protein, from Human, contains 475 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Possible role as a cell-adhesion or receptor molecule of erythroid cells

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is RING finger and CHY zinc finger domain-containing protein 1 protein, from Human, contains 261 amino acids, has 1 CHY-type Zinc finger, has 1 CTCHY-type Zinc finger, has 1 RING-type Zinc finger.

CHY-type

CTCHY-type

RING-type

Has no E3 ubiquitin-protein ligase activity


This is Zinc finger protein 385A protein, from Human, contains 386 amino acids, has 3 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

RNA-binding protein that affects the localization and the translation of a subset of mRNA, May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation, Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation, With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A, Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity, May also bind CCNB1 mRNA, Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction, Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes, May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest, Also plays a role in megakaryocytes differentiation


This is Sialic acid-binding Ig-like lectin 12 protein, from Human, contains 595 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface


This is Zinc finger protein 317 protein, from Human, contains 595 amino acids, has 13 C2H2-type Zinc finger.

May function as a transcription factor, May play an important role in erythroid maturation and lymphoid proliferation


This is E3 ubiquitin-protein ligase UHRF2 protein, from Human, contains 802 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:29506131, PubMed:27743347, PubMed:23404503), Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:27129234, PubMed:24813944), This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity), Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639), Ubiquitinates also PCNP leading to its degradation by the proteasome (PubMed:14741369, PubMed:12176013), Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055), Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor, Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751), Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395)


This is E3 ubiquitin ligase RNF157 protein, from Human, contains 679 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469), Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469), May act as a scaffold molecule to regulate this process (PubMed:25342469), Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764)


This is Serine/threonine-protein phosphatase 1 regulatory subunit 10 protein, from Human, contains 940 amino acids, has 1 C3H1-type Zinc finger.

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex, The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase, Mediates interaction of WDR82 and PPP1CA, Inhibitor of PPP1CA and PPP1CC phosphatase activities, Has inhibitory activity on PPP1CA only when phosphorylated, Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity)


This is Fc receptor-like protein 5 protein, from Human, contains 977 amino acids, has 8 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages, May have an immunoregulatory role in marginal zone B-cells, May play a role in fertilization (By similarity)


This is Zinc finger protein 300 protein, from Human, contains 604 amino acids, has 12 C2H2-type Zinc finger.

Has a transcriptional repressor activity


This is Bile acid receptor protein, from Human, contains 486 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is BRCA1-A complex subunit RAP80 protein, from Human, contains 719 amino acids, has 1 UBZ4-type Zinc finger.

Ubiquitin-binding protein (PubMed:24627472), Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref,38), Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs), The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin, May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo, Does not bind Lys-48'-linked ubiquitin, May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1


This is Sialic acid-binding Ig-like lectin 11 protein, from Human, contains 698 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, Preferentially binds to alpha-2,8-linked sialic acid, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface, In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules


This is ATPase WRNIP1 protein, from Human, contains 665 amino acids, has 1 UBZ4-type Zinc finger.

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis, In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased, Also plays a role in the innate immune defense against viruses, Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination, In turn, RIGI transmits the signal through mitochondrial MAVS

Belongs to the AAA ATPase family, RarA/MGS1/WRNIP1 subfamily


This is Pleckstrin homology domain-containing family F member 1 protein, from Human, contains 279 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May induce apoptosis through the lysosomal-mitochondrial pathway, Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm, Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8


This is Zinc finger protein 587 protein, from Human, contains 575 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger and SCAN domain-containing protein 10 protein, from Human, contains 725 amino acids, has 14 C2H2-type Zinc finger.

Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency, Can both activate and /or repress expression of target genes, depending on the context, Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence, Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4


This is RUN and FYVE domain-containing protein 1 protein, from Human, contains 708 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking


This is E3 ubiquitin-protein ligase UHRF1 protein, from Human, contains 793 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification, Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication, In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins, Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication, Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications, Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML, It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo, Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation


This is Thyroid hormone receptor alpha-A protein, from Zebrafish, contains 427 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

High affinity receptor for triiodothyronine (By similarity), In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor, Whereas in the presence of thyroid hormone, can act as an activator of transcription, In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development


This is Tyrosine-protein kinase receptor TYRO3 protein, from Chicken, contains 873 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands, Regulates many physiological processes including cell survival, migration and differentiation, Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules, Following activation by ligand, enhances PI3-kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Granulocyte colony-stimulating factor receptor protein, from Human, contains 836 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation, Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage, In addition it may function in some adhesion or recognition events at the cell surface

Belongs to the type I cytokine receptor family, Type 2 subfamily


This is Transposon Ty3-I Gag polyprotein protein, from Baker's yeast, contains 290 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Nucleocapsid protein p9 (NC) forms the nucleocore that coats the retro-elements dimeric RNA, Binds these RNAs through its zinc fingers (By similarity), Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription


This is SH3 and cysteine-rich domain-containing protein protein, from Human, contains 402 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity, Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity, Slows down the inactivation rate of the calcium channel CACNA1C


This is E3 ubiquitin-protein ligase RING2 protein, from Human, contains 336 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:33864376, PubMed:21772249, PubMed:25355358, PubMed:26151332), H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, May be involved in the initiation of both imprinted and random X inactivation (By similarity), Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332), PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332), E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249), Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable), Association with the chromosomal DNA is cell-cycle dependent, In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity), Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (By similarity)


This is Zinc finger and BTB domain-containing protein 18 protein, from Human, contains 522 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development, Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis, Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons, Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes, May also play a role in the organization of chromosomes in the nucleus

Belongs to the krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily


This is Krueppel-like factor 6 protein, from Human, contains 283 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional activator (By similarity), Binds a GC box motif, Could play a role in B-cell growth and development


This is Cell growth regulator with RING finger domain protein 1 protein, from Human, contains 332 amino acids, has 1 RING-type Zinc finger.

RING-type

Able to inhibit growth in several cell lines


This is Zinc finger protein Gfi-1 protein, from Human, contains 422 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor essential for hematopoiesis, Functions in a cell-context and development-specific manner, Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes, Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development, Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development, Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity), Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling, Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA, Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth, Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters, Required for the maintenance of inner ear hair cells


This is Killer cell immunoglobulin-like receptor 2DL4 protein, from Human, contains 377 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for non-classical major histocompatibility class Ib HLA-G molecules, Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M), In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734), May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734), Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272)


This is BRCA1-associated RING domain protein 1 protein, from Human, contains 777 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability, Plays a central role in the control of the cell cycle in response to DNA damage, Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function, Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage


This is Cell surface A33 antigen protein, from Human, contains 319 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

May play a role in cell-cell recognition and signaling


This is E3 ubiquitin-protein ligase RNF5 protein, from Human, contains 180 amino acids, has 1 RING-type Zinc finger.

RING-type

Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19285439, PubMed:19269966), May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381), Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019), Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924), Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966), Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439), Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945)


This is Semaphorin-3C protein, from Human, contains 751 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to plexin family members and plays an important role in the regulation of developmental processes, Required for normal cardiovascular development during embryogenesis, Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity)


This is Krueppel-like factor 7 protein, from Mouse, contains 301 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional factor (PubMed:11245580), Plays a critical role in neuronal morphogenesis (PubMed:11336497, PubMed:15964824), Represses the corneal epithelium differentiation (By similarity), Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells, Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (By similarity)


This is Forkhead box protein P3 protein, from Mouse, contains 429 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:22813742), Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells, Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases, The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG), Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681), Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity), Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532), Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049), Inhibits the transcriptional activator activity of RORA (By similarity), Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (PubMed:19696312)


This is TNFAIP3-interacting protein 2 protein, from Mouse, contains 430 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG, Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation, Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific, Required for stability of MAP3K8, Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival, May act as transcriptional coactivator when translocated to the nucleus, Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes


This is ADP-ribosylation factor GTPase-activating protein 2 protein, from Mouse, contains 520 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum, Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)


This is TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 protein, from Mouse, contains 693 amino acids, has 1 RanBP2-type Zinc finger.

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (By similarity), Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (By similarity), The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:19927120), Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (PubMed:12150997), Involved in heart development (By similarity)


This is Zinc finger protein 64 protein, from Mouse, contains 643 amino acids, has 12 C2H2-type Zinc finger.

May be involved in the regulation of mesenchymal cell differentiation through transactivation of NOTCH1 target genes


This is RNA-binding protein 10 protein, from Mouse, contains 930 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type; atypical Zinc finger.

C2H2-type; atypical

Not known, Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity), May bind to specific miRNA hairpins (By similarity)


This is Lipolysis-stimulated lipoprotein receptor protein, from Mouse, contains 594 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Probable role in the clearance of triglyceride-rich lipoprotein from blood, Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (PubMed:15265030), Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (PubMed:21245199, PubMed:23239027)

Belongs to the immunoglobulin superfamily, LISCH7 family


This is E3 ubiquitin-protein ligase RNF34 protein, from Mouse, contains 376 amino acids, has 1 FYVE-type Zinc finger, has 1 RING-type Zinc finger.

FYVE-type

RING-type

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins, Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis, May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway, Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation, Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN, Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484), Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation


This is Eukaryotic translation initiation factor 2 subunit 2 protein, from Mouse, contains 331 amino acids, has 1 C4-type Zinc finger.

Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC), Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex, In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B


This is Ubiquitin carboxyl-terminal hydrolase 16 protein, from Mouse, contains 825 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator, Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis, In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696), Regulates Hox gene expression via histone H2A deubiquitination, Prefers nucleosomal substrates, Does not deubiquitinate histone H2B, Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit

Belongs to the peptidase C19 family, USP16 subfamily


This is Zinc finger protein 281 protein, from Mouse, contains 893 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation, Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones, Not required for establishement and maintenance of ESCs, Represses the transcription of a number of genes including GAST, ODC1 and VIM, Binds to the G-rich box in the enhancer region of these genes

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Hepatocyte growth factor-regulated tyrosine kinase substrate protein, from Mouse, contains 775 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Involved in intracellular signal transduction mediated by cytokines and growth factors, When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF, Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin, May concentrate ubiquitinated receptors within clathrin-coated regions, Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex), The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes, May contribute to the efficient recruitment of SMADs to the activin receptor complex, Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation


This is E3 ubiquitin-protein ligase MARCHF2 protein, from Mouse, contains 246 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity), Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity), Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity), Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (PubMed:32935379), May be involved in endosomal trafficking through interaction with STX6


This is DnaJ homolog subfamily A member 3, mitochondrial protein, from Mouse, contains 480 amino acids, has 1 CR-type Zinc finger.

CR-type

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix, Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation, Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis, Can modulate IFN-gamma-mediated transcriptional activity (By similarity), Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway


This is Interleukin-11 receptor subunit alpha protein, from Rat, contains 431 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity, The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Histone acetyltransferase KAT5 protein, from Rat, contains 513 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4, Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription, The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (By similarity), The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A,Z/H2AZ1 at MYC target genes, The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity), Component of a SWR1-like complex that specifically mediates the removal of histone H2A,Z/H2AZ1 from the nucleosome, Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, ULK1 and RUBCNL/Pacer, Directly acetylates and activates ATM, Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex, Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2, Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity, Involved in skeletal myoblast differentiation by mediating acetylation of SOX4, Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (By similarity), Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity), Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer, Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation, Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1, Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase, Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol, In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation and 2-hydroxyisobutyrylation, respectively, Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins, Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis, Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes, Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment, Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (By similarity)


This is Ras association domain-containing protein 1 protein, from Mouse, contains 340 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Potential tumor suppressor, Required for death receptor-dependent apoptosis, Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation, When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation, Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression, Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein, Isoform C has been shown not to perform these roles, no function has been identified for this isoform, Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage (By similarity)


This is Zinc finger MYND domain-containing protein 10 protein, from Mouse, contains 440 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a role in axonemal structure organization and motility (PubMed:29601588), Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (PubMed:29601588), May act by indirectly regulating transcription of dynein proteins (By similarity)


This is E3 ubiquitin-protein ligase Arkadia protein, from Mouse, contains 989 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (PubMed:11298452), Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019), Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019), In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity), Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (By similarity), Associates with UBE2D2 as an E2 enzyme (By similarity), Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23530056), Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (By similarity), Mediates ubiquitination and degradation of sumoylated PML (PubMed:23530056), The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (PubMed:23530056)


This is BRCA1-associated protein protein, from Mouse, contains 591 amino acids, has 1 RING-type Zinc finger, has 1 UBP-type; degenerate Zinc finger.

RING-type

UBP-type; degenerate

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein, Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation, May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity)


This is Cell adhesion molecule 3 protein, from Mouse, contains 396 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Involved in the cell-cell adhesion, Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3, Interaction with EPB41L1 may regulate structure or function of cell-cell junctions


This is RAF proto-oncogene serine/threonine-protein kinase protein, from Mouse, contains 648 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation, RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2), The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75', Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation, Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity, Phosphorylates TNNT2/cardiac muscle troponin T, Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1), Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death, Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN, Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity), Regulates Rho signaling and migration, and is required for normal wound healing

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is Polycomb group RING finger protein 6 protein, from Mouse, contains 353 amino acids, has 1 RING-type Zinc finger.

RING-type

Transcriptional repressor, May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase, Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity


This is Triggering receptor expressed on myeloid cells 2 protein, from Mouse, contains 227 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:11241283), Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356), Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (PubMed:27477018, PubMed:29518356), Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018), Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (By similarity), Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (PubMed:28077724), Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881), Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (PubMed:15728241, PubMed:28592261, PubMed:29752066, PubMed:25631124), Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (PubMed:30232263, PubMed:29663649, PubMed:28483841, PubMed:29859094), It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (PubMed:29663649), During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (PubMed:28592261), Plays a role in microglial MTOR activation and metabolism (PubMed:28802038), Regulates age-related changes in microglial numbers (PubMed:30548312, PubMed:29752066, PubMed:25631124), Triggers activation of the immune responses in macrophages and dendritic cells (By similarity), Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693), In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity), Involved in the positive regulation of osteoclast differentiation (PubMed:16418779)


This is Leucine-rich repeat-containing protein 4 protein, from Mouse, contains 652 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Synaptic adhesion protein, Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins, Organize the lamina/pathway-specific differentiation of dendrites, Plays an important role for auditory synaptic responses, Involved in the suppression of glioma


This is E3 ubiquitin-protein ligase TRIM8 protein, from Mouse, contains 551 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:28747347, PubMed:31360105), Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497), Plays a positive role in the TNFalpha and IL-1beta signaling pathways, Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (By similarity), Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (By similarity), Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347)


This is Tripartite motif-containing protein 26 protein, from Mouse, contains 545 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs), Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA, Promotes nuclear IRF3 ubiquitination and proteasomal degradation, Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1, Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling (PubMed:34017102), In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation, Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein, Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity), Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (PubMed:33869196)


This is E3 ubiquitin-protein ligase TRIM34A protein, from Mouse, contains 485 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity), Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses, During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination, In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity), Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis, Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity), Plays an essential role in sustaining the integrity of the inner mucus layer in the colon by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504)


This is Tripartite motif-containing protein 16 protein, from Mouse, contains 556 amino acids, has 2 B box-type Zinc finger.

B box-type

B box-type

E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages, Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2, Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B, In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage


This is Tripartite motif-containing protein 12A protein, from Mouse, contains 284 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is E3 ubiquitin-protein ligase TRIM11 protein, from Mouse, contains 467 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (PubMed:18628401), Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (PubMed:18628401), May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (PubMed:18628401), May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (PubMed:12670303), Mediates MED15 ubiquitination leading to proteasomal degradation (By similarity), May contribute to the innate restriction of retroviruses (PubMed:18248090), Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090), Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090), May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090), Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (By similarity), Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity)


This is INO80 complex subunit B protein, from Mouse, contains 375 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is B-cell lymphoma/leukemia 11B protein, from Mouse, contains 884 amino acids, has 6 C2H2-type Zinc finger.

Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals (PubMed:12717433), Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity), Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611), Tumor-suppressor protein involved in T-cell lymphomas, May function on the P53-signaling pathway, Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element


This is Protein FREE1 protein, from Mouse-ear cress, contains 601 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Endosomal sorting complex required for transport (ESCRT) component regulating multivesicular body (MVB) protein sorting and plant growth (PubMed:25438943), Required for the formation of intra-luminal vesicles (ILVs)in MVBs (PubMed:25438943), Binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin (PubMed:24843126, PubMed:25438943), Controls IRT1 recycling to the plasma membrane and impacts the polar delivery of this transporter to the outer plasma membrane domain (PubMed:24843126), Regulates ubiquitin-dependent membrane protein degradation, vacuolar transport, autophagy, and vacuole biogenesis (PubMed:25624505, PubMed:25699591), ESCRT component that binds ubiquitin and regulates vacuolar sorting of proteins (PubMed:27495812), Attenuates abscisic acid (ABA) signaling through RSL1-triggered degradation of the ABA receptors PYR1 and PYL4 (PubMed:27495812), Interacts with PYL4 and PYR1, and delivers the ubiquitinated ABA receptors as cargo to the vacuolar degradation pathway (PubMed:27495812), In response to ABA, is phosphorylated by SnRK2 kinases which mediate FREE1 nuclear import (PubMed:30962512), In the nucleus, interacts with the ABA-responsive transcription factors ABF4 and ABI5 to reduce their ability to bind to their cis-regulatory sequences of downstream genes, thus leading to transcriptional inhibition of ABA signaling pathway (PubMed:30962512), Negatively regulates salt stress tolerance via a negative feedback loop involving ABA signaling pathway (PubMed:32540007)


This is Transcriptional adapter ADA2b protein, from Mouse-ear cress, contains 487 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Required for the function of some acidic activation domains, which activate transcription from a distant site, The exact mechanism of action is not yet known (By similarity), ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region, Mediates auxin and cytokinin signals in the control of cell proliferation and might be involved in repression of a freezing tolerance pathway at warm temperature (PubMed:12615937, PubMed:12747832), Involved in the positive regulation of salt-induced gene expression by maintaining locus-specific acetylation of histones H4 and H3 (PubMed:21193996)


This is Major histocompatibility complex class I-related gene protein protein, from Chimpanzee, contains 341 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells, In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity), Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis, Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity), May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin, Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity), During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity), Acts as an immune sensor of cancer cell metabolome, May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity)


This is RNA-binding protein 4 protein, from Rabbit, contains 359 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation, Modulates alternative 5'-splice site and exon selection, Acts as a muscle cell differentiation-promoting factor, Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation, Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin, Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs, Required for the translational activation of PER1 mRNA in response to circadian clock, Binds directly to the 3'-UTR of the PER1 mRNA, Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation, Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress, Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions, Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs, Associates with miRNAs during muscle cell differentiation, Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity)


This is RNA-binding protein 4B protein, from Human, contains 359 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for the translational activation of PER1 mRNA in response to circadian clock, Binds directly to the 3'-UTR of the PER1 mRNA (By similarity)


This is Zinc finger FYVE domain-containing protein 21 protein, from Human, contains 234 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions, Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression


This is Programmed cell death 1 ligand 2 protein, from Human, contains 273 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner, Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity)


This is Structure-specific endonuclease subunit SLX1 protein, from Human, contains 275 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA, Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs), Resolves HJs by generating two pairs of ligatable, nicked duplex products


This is Histone H4 transcription factor protein, from Human, contains 517 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 4; degenerate

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter, Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT, Also activates transcription of the ATM and PRKDC genes, Autoregulates its expression by associating with its own promoter


This is Transcription factor COE4 protein, from Human, contains 602 amino acids, has 1 C5-type Zinc finger.

Transcription factor (PubMed:35939714), Binds to specific sequence motif 5'-CCCNNG[GA]G-3' in regulatory elements of putative target immunoregulatory genes such as NKG7, GZMA, and TBX21 (PubMed:35939714), Positively modulates transcription of NKG7 (PubMed:35939714), May play a role in regulating FAS/CD95-mediated apoptosis in cytotoxic NK cells and T-cells, probably downstream of interleukin IL2 signaling (PubMed:35939714)


This is Matrix remodeling-associated protein 8 protein, from Human, contains 442 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

(Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses