This is Zinc finger protein GLI1 protein, from Chicken, contains 556 amino acids, has 5 C2H2-type Zinc finger.

Acts as a transcriptional activator, Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity), May regulate the transcription of specific genes during normal development (PubMed:8948590), May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract (PubMed:8948590), Mediates SHH signaling (PubMed:8948590), Plays a role in cell proliferation and differentiation via its role in SHH signaling

Belongs to the GLI C2H2-type zinc-finger protein family


This is DNA topoisomerase 1 protein, from Campylobacter pylori, contains 736 amino acids, has 4 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is Zinc finger protein neuro-d4 protein, from Rat, contains 397 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor, Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)


This is E3 ubiquitin-protein ligase Mdm2 protein, from African clawed frog, contains 473 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome


This is Probable eukaryotic translation initiation factor 2 subunit beta protein, from Fission yeast, contains 321 amino acids, has 1 C4-type Zinc finger.

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex, Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex, In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)


This is DNA topoisomerase 1 protein, from Acyrthosiphon pisum symbiotic bacterium, contains 861 amino acids, has 3 C4-type Zinc finger.


This is Estrogen receptor protein, from Atlantic croaker, contains 525 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Estrogen receptor beta protein, from Atlantic croaker, contains 673 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner


This is Estrogen receptor beta protein, from Rainbow trout, contains 568 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Estrogen receptor gamma protein, from Atlantic croaker, contains 565 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Ras GTPase-activating protein 2 protein, from Mouse, contains 847 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Inhibitory regulator of the Ras-cyclic AMP pathway, Binds inositol tetrakisphosphate (IP4) and phospholipids


This is Zinc finger protein DPF3 protein, from Chicken, contains 427 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology), Specifically binds acetylated lysines on histone 3 and 4, In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling, It thereby probably plays an essential role in heart and skeletal muscle development, Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development


This is Zinc finger protein 121 protein, from Human, contains 390 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 9 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Receptor-transporting protein 1 protein, from Human, contains 263 amino acids, has 1 3CxxC-type Zinc finger.

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs


This is Ubiquitin-ribosomal protein eS31x fusion protein protein, from Mouse-ear cress, contains 157 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is Large ribosomal subunit protein eL37A protein, from Fission yeast, contains 89 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL37 family


This is Hereditary hemochromatosis protein homolog protein, from Chimpanzee, contains 348 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin


This is Zinc finger protein ZFPM1 protein, from Zebrafish, contains 224 amino acids, has 2 CCHC FOG-type Zinc finger.

CCHC FOG-type

CCHC FOG-type

Transcription regulator that modulates expression mediated by transcription factors of the GATA family, Cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family, Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context (By similarity)

Belongs to the FOG (Friend of GATA) family


This is MAM domain-containing glycosylphosphatidylinositol anchor protein 2 protein, from Rat, contains 949 amino acids, has 6 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

May be involved in cell-cell interactions


This is Large ribosomal subunit protein eL43 protein, from Rat, contains 92 amino acids, has 1 C4-type Zinc finger.

Component of the large ribosomal subunit, The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell

Belongs to the eukaryotic ribosomal protein eL43 family


This is Aprataxin protein, from Zebrafish, contains 324 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair, Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species, Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined, Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity), Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)


This is Aprataxin protein, from Japanese pufferfish, contains 356 amino acids, has 1 C2H2-type Zinc finger.


This is Aprataxin protein, from Western clawed frog, contains 347 amino acids, has 1 C2H2-type Zinc finger.


This is Aprataxin protein, from Transparent sea squirt, contains 380 amino acids, has 1 C2H2-type; atypical Zinc finger.

C2H2-type; atypical


This is Large ribosomal subunit protein eL37 protein, from Rat, contains 97 amino acids, has 1 C4-type Zinc finger.


This is Tripartite motif-containing protein 26 protein, from Rat, contains 542 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs), Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA, Promotes nuclear IRF3 ubiquitination and proteasomal degradation, Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1, Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling, In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation, Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein, Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity), Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity)


This is Endogenous retrovirus group K member 21 Gag polyprotein protein, from Human, contains 666 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle, During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell, Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA, Endogenous Gag proteins may have kept, lost or modified their original function during evolution

Belongs to the beta type-B retroviral Gag protein family, HERV class-II K(HML-2) gag subfamily


This is Endogenous retrovirus group K member 113 Gag polyprotein protein, from Human, contains 666 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Endogenous retrovirus group K member 8 Gag polyprotein protein, from Human, contains 647 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Tomato, contains 156 amino acids, has 1 C4-type Zinc finger.


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Potato, contains 156 amino acids, has 1 C4-type Zinc finger.


This is Endogenous retrovirus group K member 9 Gag polyprotein protein, from Human, contains 666 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Endogenous retrovirus group K member 7 Gag polyprotein protein, from Human, contains 666 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Endogenous retrovirus group K member 113 Pol protein protein, from Human, contains 956 amino acids, has 1 Integrase-type Zinc finger.

Integrase-type

Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA, The RNase H domain of the reverse transcriptase performs two functions, It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid, Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome, Endogenous Pol proteins may have kept, lost or modified their original function during evolution

Belongs to the beta type-B retroviral polymerase family, HERV class-II K(HML-2) pol subfamily


This is Endogenous retrovirus group K member 8 Pol protein protein, from Human, contains 956 amino acids, has 1 Integrase-type Zinc finger.

Integrase-type


This is Endogenous retrovirus group K member 25 Pol protein protein, from Human, contains 954 amino acids, has 1 Integrase-type Zinc finger.

Integrase-type

Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA, The RNase H domain of the reverse transcriptase performs two functions, It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid, Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome, Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity)


This is Endogenous retrovirus group K member 24 Gag polyprotein protein, from Human, contains 666 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Transcription elongation factor SPT4-A protein, from Mouse, contains 117 amino acids, has 1 C4-type Zinc finger.

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II, DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A, DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter, Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex, DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II, TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme, Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity)


This is Formamidopyrimidine-DNA glycosylase protein, from Xylella fastidiosa (strain 9a5c), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is Formamidopyrimidine-DNA glycosylase protein, from Xylella fastidiosa (strain Temecula1 / ATCC 700964), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Channel catfish, contains 156 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome, Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Diamondback moth, contains 155 amino acids, has 1 C4-type Zinc finger.


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Fall armyworm, contains 156 amino acids, has 1 C4-type Zinc finger.


This is Interleukin-12 subunit beta protein, from Sheep, contains 327 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity, IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues, IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines, IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity)


This is Thyroid hormone receptor beta protein, from Chicken, contains 369 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Viral late gene transcription factor 3 protein, from VACV, contains 224 amino acids, has 1  Zinc finger.

Acts with RNA polymerase to initiate transcription from late gene promoters

Belongs to the orthopoxvirus VLTF-3/OPG127 family


This is Dof zinc finger protein DOF1.5 protein, from Mouse-ear cress, contains 175 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence, Acts as a negative regulator in the phytochrome-mediated light responses, Controls phyB-mediated end-of-day response and the phyA-mediated anthocyanin accumulation, Not involved in direct flowering time regulation


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Yeast, contains 150 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome


This is Gag polyprotein protein, from EIAV, contains 486 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p9 plays a role in budding of the assembled particle by interacting with PDCD6IP/AIP1

Belongs to the equine lentivirus group gag polyprotein family


CCHC-type

CCHC-type


This is GATA transcription factor 12 protein, from Mouse-ear cress, contains 331 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters, May be involved in the regulation of some light-responsive genes (By similarity), Transcription activator involved in xylem formation, Functions upstream of NAC030/VND7, a master switch of xylem vessel differentiation (PubMed:25265867)

Belongs to the type IV zinc-finger family, Class A subfamily


This is GATA-binding factor 6-B protein, from African clawed frog, contains 391 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that binds 5'-GATA-3'-containing motifs within gene promoters, Regulates cardiac-specific transcription during embryogenesis and thereby cardiogenesis


This is Zinc fingers and homeoboxes protein 1 protein, from Mouse, contains 873 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor, Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA, May link molecule between DNMT3B and other co-repressor proteins (By similarity)


This is Interleukin-11 receptor subunit alpha-2 protein, from Mouse, contains 432 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Receptor for interleukin-11, The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission, The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Formamidopyrimidine-DNA glycosylase protein, from Synechocystis sp. (strain PCC 6803 / Kazusa), contains 287 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is DNA topoisomerase 1 protein, from Mycoplasmoides pneumoniae, contains 711 amino acids, has 2 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is White collar 2 protein protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 530 amino acids, has 1 GATA-type Zinc finger.

GATA-type

May function as a transcription factor involved in light regulation, Binds and affects blue light regulation of the al-3 gene, Wc-1 and wc-2 interact via homologous PAS domains, bind to promoters of light regulated genes such as frq, and activate transcription, May bind directly to frq


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Bovine, contains 250 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG), Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC), Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity), Mediates IgG effector functions on natural killer (NK) cells, Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity), Fc-binding subunit that associates with FCER1G adapters to form functional signaling complexes, Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (By similarity)


This is T-cell surface glycoprotein CD4 protein, from Japanese macaque, contains 458 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is T-cell surface glycoprotein CD4 protein, from Crab-eating macaque, contains 458 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Krueppel-like factor 9 protein, from Pig, contains 244 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to GC box promoter elements, Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box, Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Progesterone receptor protein, from Tammar wallaby, contains 180 amino acids, has 1 NR C4-type Zinc finger.

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcriptional activator of several progesteron-dependent promoters in a variety of cell types, Involved in activation of SRC-dependent MAPK signaling on hormone stimulation


This is Wilms tumor protein homolog B protein, from African clawed frog, contains 407 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor required for development of the vascular component of the pronephric kidney, the glomus; may repress tubule-specific gene expression in the portion of the pronephros fated to form the glomus (PubMed:16818449), Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity), Inhibits Wnt-signaling during embryonic development (By similarity)

Belongs to the EGR C2H2-type zinc-finger protein family


This is Immunoglobulin lambda variable 3-21 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)


This is Estrogen receptor protein, from African clawed frog, contains 586 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues


This is E3 ubiquitin-protein ligase Midline-1 protein, from Western Mediterranean mouse, contains 667 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination


This is Venom metalloproteinase inhibitor DM43 protein, from Southern opossum, contains 291 amino acids, has 3 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type


This is Putative protein kinase C delta type homolog protein, from Fruit fly, contains 671 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is T-cell immunoreceptor with Ig and ITIM domains protein, from Mouse, contains 249 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells


This is SWM histone demethylase complex subunit phf1 protein, from Fission yeast, contains 461 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor, Has a role in regulating heterochromatin propagation and euchromatic transcription


This is Endogenous retrovirus group K member 10 Gag polyprotein protein, from Human, contains 666 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle, During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell, Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA, Endogenous Gag proteins may have kept, lost or modified their original function during evolution


This is E3 ubiquitin-protein ligase hrd-like protein 1 protein, from Caenorhabditis elegans, contains 564 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Proposed to have a role in neuroprotection


This is E3 ubiquitin-protein ligase trul-1 protein, from Caenorhabditis elegans, contains 451 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin ligase that acts as a key regulator of DNA repair in response to replication stress (PubMed:31545170, PubMed:30849395), Acts by mediating ubiquitination of the CMG helicase complex, promoting the unloading of the CMG helicase complex by the p97 ATPase (cdc-48,1 or cdc-48,2) (PubMed:31545170, PubMed:30849395)


This is GATA-binding factor C protein, from Fruit fly, contains 486 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcription factor that is vital to the development of multiple organ systems, Binds to the core consensus sequence 5'-WGATAR-3'


This is E3 ubiquitin-protein ligase COP1 protein, from Garden pea, contains 672 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors, Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm, Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways


This is Retinitis pigmentosa 9 protein homolog protein, from Mouse, contains 213 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Is thought to be a target protein for the PIM1 kinase, May play some roles in B-cell proliferation in association with PIM1


This is Zinc finger X-linked protein ZXDB protein, from Human, contains 803 amino acids, has 10 C2H2-type Zinc finger.

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes


This is Chaperone protein DnaJ 2 protein, from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), contains 382 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity), Inhibits the beta-lactamase and RNase activity of RNase J


This is Chaperone protein DnaJ 1 protein, from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), contains 395 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is DNA primase protein, from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), contains 639 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is Early growth response protein 4 protein, from Rat, contains 478 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator, Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG), Activates the transcription of target genes whose products are required for mitogenesis and differentiation


This is Peroxisome biogenesis factor 10 protein, from Yeast, contains 295 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling, The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane, PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase, When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation


This is Protein OPG185 protein, from VACV, contains 314 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane, The OPG185-OPG040 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation, Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack

Belongs to the orthopoxvirus OPG185 family


This is Replication protein A 70 kDa DNA-binding subunit protein, from African clawed frog, contains 609 amino acids, has 1 C4-type Zinc finger.

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress, It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism, Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage

Belongs to the replication factor A protein 1 family


This is Krueppel-like factor 9 protein, from Rat, contains 244 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to GC box promoter elements, Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box, Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation


This is Peroxisome assembly protein 12 protein, from Yeast, contains 409 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 and/or PEX20 receptors from peroxisomes to the cytosol, thereby promoting PEX5 and PEX20 recycling (PubMed:23344950), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 and/or PEX20 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 and/or PEX20 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity), When PEX5 or PEX20 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5 and/or PEX20, leading to its subsequent degradation (By similarity)


This is Zinc-binding protein A33 protein, from Iberian ribbed newt, contains 625 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

May be a nuclear regulatory protein that is stored in the germinal vesicle for use during early embryogenesis and may play a role in the synthesis or processing of pre-mRNA during oogenesis, Binds 3 Zn(2+) ions


This is Zinc finger protein 45 protein, from Human, contains 682 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 17 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Postreplication repair E3 ubiquitin-protein ligase rad18 protein, from Aspergillus nidulans, contains 443 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group, Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA


This is Thyroid hormone receptor alpha protein, from American bullfrog, contains 418 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine


This is Beta-chimaerin protein, from Rat, contains 295 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type


This is RING finger protein nhl-1 protein, from Caenorhabditis elegans, contains 974 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Zinc finger protein 92 protein, from Human, contains 586 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 11 C2H2-type Zinc finger, has 1 C2H2-type 14; degenerate Zinc finger, has 1 C2H2-type 15; degenerate Zinc finger, has 1 C2H2-type 16; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 14; degenerate

C2H2-type 15; degenerate

C2H2-type 16; degenerate


This is ADP-ribosylation factor GTPase-activating protein effector protein 1 protein, from Baker's yeast, contains 482 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for the ADP ribosylation factors ARF1 and ARF2, May be involved in the endocytic pathway


This is DnaJ protein homolog protein, from Cucumber, contains 413 amino acids, has 1 CR-type Zinc finger.

CR-type

Plays a continuous role in plant development probably in the structural organization of compartments


This is Homeobox protein HAT3.1 protein, from Mouse-ear cress, contains 723 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Binds only to large DNA fragments, Recognizes a DNA fragment carrying 8 copies of box7 motif of the light-induced cab-E promoter of Nicotiana plumbaginifolia, Also recognizes the box7m1 motif

Belongs to the PHD-associated homeobox family


This is Early growth response protein 2b protein, from Zebrafish, contains 412 amino acids, has 3 C2H2-type Zinc finger.

Sequence-specific DNA-binding transcription factor, Binds to two specific DNA sites located in the promoter region of HOXA4


This is Vacuolar import and degradation protein 22 protein, from Baker's yeast, contains 901 amino acids, has 1 BED-type Zinc finger.

BED-type

Has a role in the negative regulation of gluconeogenesis, Imports fructose-1,6-bisphosphatase (FBPase) into the intermediate vacuole import and degradation (Vid) vesicles, This is an indirect role and requires cyclophilin A


This is RNA-binding E3 ubiquitin-protein ligase MEX3C protein, from Mouse, contains 652 amino acids, has 1 RING-type Zinc finger.

RING-type

RNA-binding protein, May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity, May act as suppressor of replication stress and chromosome missegregation


This is Ubiquitin thioesterase OTU1 protein, from Bovine, contains 348 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore, Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel, Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains, Also able to hydrolyze 'Lys-11'-linked ubiquitin chains, Cleaves both polyubiquitin and di-ubiquitin, May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes, May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation


This is E3 ubiquitin-protein ligase MAG2 protein, from Baker's yeast, contains 670 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase involved in the degradation of non-functional 18S rRNAs in response to stalled ribosomes (PubMed:30893611), Catalyzes monoubiquitination of RPS3/uS3 in response to stalled ribosomes, initiating a HEL2-dependent response that activates the degradation of non-functional 18S rRNAs (PubMed:30893611)


This is Transcriptional activator protein protein, from ToMoV, contains 129 amino acids, has 1  Zinc finger.

Strong activator of the late viral genes promoters, Enhances the expression of the capsid protein and nuclear shuttle protein, Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs, Suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway, Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense, Determines pathogenicity (By similarity)

Belongs to the geminiviridae transcriptional activator protein family


This is Cytoplasmic 60S subunit biogenesis factor REH1 protein, from Baker's yeast, contains 432 amino acids, has 3 C2H2-type Zinc finger.

Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit, May act redundantly with REI1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on the REI1-specific ARX1 recycling


This is Nuclear receptor subfamily 2 group F member 5 protein, from Zebrafish, contains 403 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Putative receptor that is required in photoreceptor cells precursors during eye development

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Zinc finger protein 33B protein, from Human, contains 778 amino acids, has 16 C2H2-type Zinc finger.


This is Alcohol-sensitive RING finger protein 1 protein, from Baker's yeast, contains 288 amino acids, has 1 RING-type 1; atypical Zinc finger, has 1 RING-type 2; degenerate Zinc finger.

RING-type 1; atypical

RING-type 2; degenerate


This is Rabphilin-3A protein, from Bovine, contains 704 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity), At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:9450942), In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability, Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity)

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane


This is DNA topoisomerase 1 protein, from Staphylococcus aureus, contains 689 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is Nanos homolog 1 protein, from African clawed frog, contains 128 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type

Acts as a translational repressor, Can mediate repression affecting different steps in the translation process: cap-driven, IRES-driven, polyadenylated RNAs or nonpolyadenylated RNAs, Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival


This is Formamidopyrimidine-DNA glycosylase protein, from Anacystis nidulans, contains 282 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is T-cell surface glycoprotein CD4 protein, from Sooty mangabey, contains 397 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is T-cell surface glycoprotein CD4 protein, from Green monkey, contains 458 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is T-cell surface glycoprotein CD4 protein, from Pig-tailed macaque, contains 458 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is E3 ubiquitin-protein ligase RNF19B protein, from African clawed frog, contains 687 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1, Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells, Protects against staurosporin-induced cell death (By similarity)

Belongs to the RBR family, RNF19 subfamily


This is E3 ubiquitin-protein ligase znrf2 protein, from Zebrafish, contains 217 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Lysine-specific demethylase 7A protein, from Western clawed frog, contains 922 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone demethylase required for brain development, Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity)

Belongs to the JHDM1 histone demethylase family, JHDM1D subfamily


This is RING finger protein 11 protein, from Bovine, contains 154 amino acids, has 1 RING-type Zinc finger.

RING-type

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways, Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains, This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B, Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome (By similarity)


This is Proto-oncogene vav protein, from Bovine, contains 844 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation


This is PHD finger protein 6 protein, from Bovine, contains 365 amino acids, has 2 C2HC pre-PHD-type Zinc finger, has 2 PHD-type Zinc finger.

C2HC pre-PHD-type

PHD-type

C2HC pre-PHD-type

PHD-type

Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription


This is E3 ubiquitin-protein ligase RNF220 protein, from Bovine, contains 566 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity), Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (By similarity)


This is Sodium channel subunit beta-4 protein, from Bovine, contains 228 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Modulates channel gating kinetics, Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation, Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity)

Belongs to the sodium channel auxiliary subunit SCN4B (TC 8,A,17) family


This is E3 ubiquitin-protein ligase RNF10 protein, from Bovine, contains 810 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling, Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome, Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation, The action of RNF10 in iRQC is counteracted by USP10 (By similarity), May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression, Acts as a regulator of Schwann cell differentiation and myelination (By similarity)


This is WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 protein, from Bovine, contains 574 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease-inhibitor that contains multiple distinct protease inhibitor domains, Probably has serine protease- and metalloprotease-inhibitor activity, Inhibits the biological activity of mature myostatin, but not activin (By similarity)


This is Zinc finger protein 543 protein, from Human, contains 600 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is 43 kDa receptor-associated protein of the synapse homolog protein, from Caenorhabditis elegans, contains 596 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction


This is E3 ubiquitin-protein ligase arc-1 protein, from Caenorhabditis elegans, contains 539 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

In the C-terminal section; belongs to the small GTPase superfamily, Arf family


This is Probable ubiquitin carboxyl-terminal hydrolase 8 protein, from Fission yeast, contains 449 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Belongs to the peptidase C19 family, UBP8 subfamily


This is Protein BZZ1 protein, from Fission yeast, contains 642 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Plays a role in endocytosis and trafficking to the vacuole, Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress (By similarity)


This is Putative general negative regulator of transcription C16C9.04c protein, from Fission yeast, contains 489 amino acids, has 1 RING-type Zinc finger, has 1 C3H1-type Zinc finger.

RING-type

May negatively regulate the basal and activated transcription of many genes


This is SWM histone demethylase complex subunit phf2 protein, from Fission yeast, contains 538 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor, Has a role in regulating heterochromatin propagation and euchromatic transcription


This is Gag polyprotein protein, from HTLV-3, contains 422 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Nucleocapsid protein p15 is involved in the packaging and encapsidation of two copies of the genome


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Olive baboon, contains 254 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG), Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC), Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity), Mediates IgG effector functions on natural killer (NK) cells, Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation, Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC, Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity), Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes, Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation, The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation, Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity), Mediates the antitumor activities of therapeutic antibodies, Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (By similarity)


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Sooty mangabey, contains 254 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG), Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC), Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity), Mediates IgG effector functions on natural killer (NK) cells, Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation, Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC, Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity), Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes, Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation, The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (By similarity), Costimulates NK cells and trigger lysis of target cells independently of IgG binding, Mediates the antitumor activities of therapeutic antibodies, Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Aspergillus terreus (strain NIH 2624 / FGSC A1156), contains 719 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)

Belongs to the Dus family, Dus3 subfamily


This is Zinc finger protein 763 protein, from Human, contains 394 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 6 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate


This is DEAD-box ATP-dependent RNA helicase 3, chloroplastic protein, from Rice, contains 758 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Nuclear genome-encoded factor involved in ribosome biogenesis in chloroplasts, Binds specific group II introns in chloroplasts and facilitates their splicing, Required for normal development of chloroplasts

Belongs to the DEAD box helicase family, DDX21/DDX50 subfamily


This is Retinoic acid receptor RXR-gamma protein, from Pig, contains 463 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)


This is Ubiquitin thioesterase OTU1 protein, from African clawed frog, contains 304 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore, Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel, Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains, Also able to hydrolyze 'Lys-11'-linked ubiquitin chains, Cleaves both polyubiquitin and di-ubiquitin


This is Protein YABBY 5 protein, from Rice, contains 266 amino acids, has 1 C4-type Zinc finger.

May be involved in leaf cell growth and differentiation, rather than abaxial cell fate determination


This is E3 ubiquitin-protein ligase MARCHF4 protein, from Zebrafish, contains 421 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is N-lysine methyltransferase SMYD2 protein, from Bovine, contains 433 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Zinc finger CCCH domain-containing protein 18 protein, from Mouse, contains 948 amino acids, has 1 C3H1-type Zinc finger.


This is Transcription factor GATA-4 protein, from Dog, contains 442 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development, In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression, Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression, Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions, Acts as a transcriptional activator of ANF in cooperation with NKX2-5, Promotes cardiac myocyte enlargement, Required during testicular development, May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase


CCHC-type

CCHC-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha protein, from Frankia alni (strain ACN14a), contains 609 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity)

In the C-terminal section; belongs to the AccA family


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Glume blotch fungus, contains 739 amino acids, has 2 C3H1-type Zinc finger.


This is Ubiquitin carboxyl-terminal hydrolase 44 protein, from Western clawed frog, contains 652 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset, Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity)

Belongs to the peptidase C19 family, USP44 subfamily


This is E3 ubiquitin-protein ligase arkadia protein, from Western clawed frog, contains 954 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity), Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP, Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP, Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity), The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity)


This is Retinoic acid receptor RXR-gamma protein, from Bovine, contains 463 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Zinc finger protein 367 protein, from Mouse, contains 340 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional activator, Isoform 1 may be involved in transcriptional activation of erythroid genes (By similarity)


This is Probable E3 ubiquitin-protein ligase WAVH2 protein, from Mouse-ear cress, contains 717 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable E3 ubiquitin-protein ligase involved in the regulation of root growth, Acts as positive regulator of root gravitropism


This is Protein SENSITIVE TO PROTON RHIZOTOXICITY 2 protein, from Mouse-ear cress, contains 373 amino acids, has 2 C2H2-type Zinc finger.

Probable transcription factor, Together with STOP1, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+), Required for the expression of genes in response to acidic stress (e,g, ALMT1 and MATE), and Al-activated citrate exudation


This is E3 ubiquitin-protein ligase MARCHF5 protein, from Green monkey, contains 278 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission, May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control, Promotes ubiquitination of FIS1, DNM1L and MFN1


This is Peroxisome proliferator-activated receptor delta protein, from Dog, contains 441 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues, Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid, Once activated by a ligand, the receptor binds to promoter elements of target genes, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the acyl-CoA oxidase gene, Decreases expression of NPC1L1 once activated by a ligand

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Probable ribosylation factor GTPase-activating protein cnt6 protein, from Fission yeast, contains 923 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for the ADP ribosylation factor family


This is SET domain-containing protein 3 protein, from Fission yeast, contains 859 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin, Required for both gene activation and repression, Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis, Required for the transcriptional activation of genes with high activity (By similarity)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET3 subfamily


This is RNA-binding protein rnp-1 protein, from Caenorhabditis elegans, contains 305 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development


This is E3 ubiquitin-protein ligase SRFP1 protein, from Rice, contains 260 amino acids, has 1 CHY-type Zinc finger, has 1 CTCHY-type Zinc finger, has 1 RING-type; atypical Zinc finger.

CHY-type

CTCHY-type

RING-type; atypical

Possesses E3 ubiquitin-protein ligase activity in vitro, Possesses transactivation activity in yeast cells, May modulate abiotic stress responses by negatively regulating antioxidant enzymes-mediated reactive oxygen species (ROS) removal


This is Protein TITANIA protein, from Rice, contains 727 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Probable transcription factor that functions as regulator of metal transporter genes responsible for essential metals delivery to shoots and normal plant growth (PubMed:30194869), Required for the maintenance of metal transporter gene expression, such as IRT1, IRT2, ZIP1, ZIP9, NRAMP1 and NRAMP5 (PubMed:30194869)


This is Replication protein A 70 kDa DNA-binding subunit B protein, from Rice, contains 630 amino acids, has 1 C4-type Zinc finger.

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication, The activity of RPA is mediated by single-stranded DNA binding and protein interactions, Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity)

Belongs to the replication factor A protein 1 family


This is Receptor homology region, transmembrane domain- and RING domain-containing protein 1 protein, from Rice, contains 533 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Involved in the trafficking of vacuolar proteins, Functions probably as a sorting receptor for protein trafficking to the protein storage vacuole (PSV) by binding the C-terminal vacuolar sorting determinant (VSD) of vacuolar-sorted proteins


This is Ubiquitin carboxyl-terminal hydrolase 14 protein, from Fission yeast, contains 775 amino acids, has 1 UBP-type 1; degenerate Zinc finger, has 1 UBP-type Zinc finger.

UBP-type 1; degenerate

UBP-type


This is Poly [ADP-ribose] polymerase protein, from Flesh fly, contains 996 amino acids, has 2 PARP-type Zinc finger.

PARP-type

PARP-type

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair, Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units


This is Translation machinery-associated protein 46 protein, from Baker's yeast, contains 345 amino acids, has 2 C3H1-type Zinc finger.


This is General transcription and DNA repair factor IIH subunit TFB4 protein, from Baker's yeast, contains 338 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription


This is RING finger protein PSH1 protein, from Baker's yeast, contains 406 amino acids, has 1 RING-type Zinc finger.

RING-type


This is RNA polymerase II subunit B1 CTD phosphatase RTR2 protein, from Baker's yeast, contains 196 amino acids, has 1 RTR1-type Zinc finger.

Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription, May have functional redundancy with RTR1


This is Zinc finger protein 155 protein, from Human, contains 538 amino acids, has 11 C2H2-type Zinc finger, has 1 C2H2-type 12; degenerate Zinc finger.

C2H2-type 12; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Myosin-binding protein H protein, from Human, contains 477 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Binds to myosin; probably involved in interaction with thick myofilaments in the A-band

Belongs to the immunoglobulin superfamily, MyBP family


This is Putative E3 ubiquitin-protein ligase makorin-4 protein, from Human, contains 485 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins


This is Dystrophin-related protein 2 protein, from Human, contains 957 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells, Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane, Possibly involved in membrane-cytoskeleton interactions of the central nervous system


This is Zinc finger protein 235 protein, from Human, contains 738 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 15 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Zinc finger protein 273 protein, from Human, contains 569 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 10 C2H2-type Zinc finger, has 1 C2H2-type 8; degenerate Zinc finger, has 1 C2H2-type 13; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 8; degenerate

C2H2-type 13; degenerate


This is Matrix remodeling-associated protein 8 protein, from Bovine, contains 463 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3, Mediates heterophilic cell-cell interactions in vitro, Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38, Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes, Stimulates formation of primary cilia in chondrocytes, Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway, Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis, Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells, Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK, May play a role in the maturation and maintenance of the blood-brain barrier


This is Killer cell immunoglobulin-like receptor 2DS3 protein, from Human, contains 304 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for HLA-C alleles, Does not inhibit the activity of NK cells

Belongs to the immunoglobulin superfamily


This is Platelet-derived growth factor receptor-like protein protein, from Human, contains 375 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is Pregnancy-specific beta-1-glycoprotein 5 protein, from Human, contains 335 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, CEA family


This is Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 protein, from Human, contains 479 amino acids, has 2 C3H1-type Zinc finger.


This is Zinc finger protein 77 protein, from Human, contains 545 amino acids, has 12 C2H2-type Zinc finger.


This is Zinc finger protein 79 protein, from Human, contains 498 amino acids, has 11 C2H2-type Zinc finger.


This is Pregnancy-specific beta-1-glycoprotein 3 protein, from Human, contains 428 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Calcium-dependent protein kinase C protein, from California sea hare, contains 649 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins, PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Calcium-independent protein kinase C protein, from California sea hare, contains 743 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type


This is Zinc finger protein mnm-2 protein, from Caenorhabditis elegans, contains 249 amino acids, has 3 C2H2-type Zinc finger.

Required in the M3 pharyngeal motor neuron to guide the growth cone of the sister M2 motor neuron during axon development


This is Sodium channel subunit beta-1 protein, from Bovine, contains 218 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle, Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation, Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A

Belongs to the sodium channel auxiliary subunit SCN1B (TC 8,A,17) family


This is Nuclear hormone receptor family member nhr-31 protein, from Caenorhabditis elegans, contains 583 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Belongs to the nuclear hormone receptor family


This is FLYWCH transcription factor 2 protein, from Caenorhabditis elegans, contains 470 amino acids, has 1 FLYWCH-type Zinc finger.

FLYWCH-type

Probable transcription factor (PubMed:18794349), May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-1 and flh-3 (PubMed:18794349)


This is Nuclear hormone receptor family member nhr-43 protein, from Caenorhabditis elegans, contains 449 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor (By similarity), Positively modulates expression of homeobox protein lin-39, perhaps by binding to the sequence motif 5'-TGAC-3' in regulatory regions of the lin-39 gene, acting in the embryo, and also in the vulval lineage (PubMed:24885717)


This is Neuronal immunoglobulin domain-containing protein rig-3 protein, from Caenorhabditis elegans, contains 487 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling


This is REST corepressor spr-1 protein, from Caenorhabditis elegans, contains 558 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1 (PubMed:12381669), Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones (PubMed:12381669), Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation (PubMed:17070797)


This is Peroxisome assembly protein 12 protein, from Caenorhabditis elegans, contains 359 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5/prx-5 receptor from peroxisomes to the cytosol, thereby promoting PEX5/prx-5 recycling (By similarity), The retrotranslocation channel is composed of PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5/prx-5 through the peroxisomal membrane (By similarity), PEX12/prx-12 also regulates PEX5/prx-5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10/prx-10 (By similarity), When PEX5 recycling is compromised, PEX12/prx-12 stimulates PEX10-mediated polyubiquitination of PEX5/prx-5, leading to its subsequent degradation (By similarity)


This is Zinc finger protein ztf-2 protein, from Caenorhabditis elegans, contains 360 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor (PubMed:16777607), Represses gene expression, probably via binding to DNA consensus sequence 5'-[AT][CT]TTCC[AC][AG]-3' in promoter regions (PubMed:16777607), May play a role in pharynx morphogenesis (PubMed:16777607)


This is Zinc finger BED domain-containing protein 3 protein, from Caenorhabditis elegans, contains 599 amino acids, has 1 BED-type Zinc finger.

BED-type

Probable transcription factor (PubMed:20005870, PubMed:24885717), Involved in vulval organogenesis (PubMed:20005870, PubMed:24885717), During vulval development, may play a role in the regulation of cell cycle regulators such as cul-1 (PubMed:20005870), Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717), Plays a role in larval molting (PubMed:20005870)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Valley fever fungus, contains 724 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)


This is Protein RGF1 INDUCIBLE TRANSCRIPTION FACTOR 1 protein, from Mouse-ear cress, contains 256 amino acids, has 1 B box-type Zinc finger.

B box-type

Probable transcription factor that plays a central role in mediating RGF1 hormone peptide signaling leading to the production of reactive oxygen species (ROS) in roots to modulate meristem size and root growth, probably via oxidative post-translational modification of the transcription factor PLETHORA (e,g, PLT1 and PLT2)


This is Telomere zinc finger-associated protein protein, from Mouse, contains 681 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Telomere-binding protein that acts as a regulator of telomere length, Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat, Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres, Also acts as a transcription regulator that binds to promoter regions, Regulates expression of a small subset of genes, including MTFP1, Regulates expression the J and/or S elements in MHC II promoter, Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A


This is Hemolin protein, from Moth, contains 413 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Bristle toxin involved in caterpillar defense by participating in hemorrhagic syndrome characterized by a consumptive coagulopathy (PubMed:21177860), Exhibits procoagulant activity through selective factor X proteolytic activation (PubMed:21177860), Activates factor X in a dose- and time-dependent manner but does not activate gamma-carboxyglutamic acid domainless factor X (PubMed:21177860), Its activity does not depend on calcium ions (PubMed:21177860), Also functions as a growth stimulator and an inhibitor of cellular death for endothelial cells (PubMed:16597435), In vitro, increases proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits the apoptosis induced by starvation (PubMed:16597435), Also increases slightly the complement decay-accelerating factor (CD55), which protects cells from complement-mediated lysis (PubMed:16597435), On the other hand, does not alter the release or expression of von Willebrand factor (VWF), tissue factor (F3), intercellular adhesion molecule-1 (ICAM1), interleukin-8 (CXCL8), and prostacyclin (PubMed:16597435), Does not show fibrinolytic or fibrinogenolytic activities (PubMed:21177860)


This is E3 ubiquitin-protein ligase RNF19B protein, from Zebrafish, contains 701 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1, Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells, Protects against staurosporin-induced cell death

Belongs to the RBR family, RNF19 subfamily


This is E3 ubiquitin-protein ligase MARCHF2 protein, from Zebrafish, contains 249 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Putative histone deacetylase complex subunit cti6 protein, from Fission yeast, contains 424 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Could be a component of the RPD3C(L) histone deacetylase complex (HDAC)


This is DNA topoisomerase 1 protein, from Rickettsia bellii (strain RML369-C), contains 800 amino acids, has 1 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is RNA-binding protein 5 protein, from Bovine, contains 815 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type Zinc finger.

Component of the spliceosome A complex, Regulates alternative splicing of a number of mRNAs, May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron, May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2, In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis, In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity)


This is Cell adhesion molecule 3 protein, from Rat, contains 396 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Involved in the cell-cell adhesion, Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3, Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)


This is Tripartite motif-containing protein 72 protein, from Rabbit, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites, Specifically binds phosphatidylserine, Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site, This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation, Probably acts upstream of the Ca(2+)-dependent membrane resealing process, Required for transport of DYSF to sites of cell injury during repair patch formation, Regulates membrane budding and exocytosis, May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity)


This is Histone deacetylase 6 protein, from Caenorhabditis elegans, contains 955 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Probable histone deacetylase, Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Histone deacetylases act via the formation of large multiprotein complexes (By similarity)

Belongs to the histone deacetylase family, HD type 2 subfamily


This is Suppressor of activated egl-4 protein 1 protein, from Caenorhabditis elegans, contains 900 amino acids, has 1 C2H2-type Zinc finger.

As a likely component of a histone deacetylase complex, together with saeg-2 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging


This is Nuclear hormone receptor family member nhr-34 protein, from Caenorhabditis elegans, contains 631 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Eukaryotic translation initiation factor 2 subunit 2 protein, from Caenorhabditis elegans, contains 250 amino acids, has 1 C4-type Zinc finger.

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex, Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex, In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)


This is Nuclear hormone receptor family member nhr-1 protein, from Caenorhabditis elegans, contains 445 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor which acts in concert with the insulin/IGF-1-like signaling (IIS) pathway during osmotic stress, perhaps in response to a ligand modified by the sulfotransferase ssu-1


This is Zwei Ig domain protein zig-6 protein, from Caenorhabditis elegans, contains 243 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons


This is Nuclear hormone receptor family member nhr-40 protein, from Caenorhabditis elegans, contains 450 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor (Probable), Plays a role in morphogenesis and elongation during embryonic and larval development (PubMed:16920335), Plays a role in muscle formation and motility (PubMed:16920335, PubMed:18616929)