This is Nectin-3 protein, from Mouse, contains 549 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions, Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1, Also involved in the formation of cell-cell junctions, including adherens junctions and synapses, Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation, Plays a role in the morphology of the ciliary body


This is Erythroid membrane-associated protein protein, from Mouse, contains 566 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Possible role as a cell-adhesion or receptor molecule of erythroid cells

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is ARF GTPase-activating protein GIT2 protein, from Mouse, contains 708 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1


This is Single Ig IL-1-related receptor protein, from Mouse, contains 409 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways, Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4, Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity)

Belongs to the interleukin-1 receptor family


This is E3 SUMO-protein ligase PIAS4 protein, from Mouse, contains 507 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway, Involved in gene silencing, In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations, Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (By similarity), Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs) (PubMed:11731474), Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity), Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (By similarity)


This is Rab5 GDP/GTP exchange factor protein, from Mouse, contains 491 amino acids, has 1 A20-type Zinc finger.

Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A, Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes, Stimulates nucleotide exchange on RAB5A (By similarity), Can act as a ubiquitin ligase (By similarity)


This is Cytokine receptor-like factor 1 protein, from Mouse, contains 425 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity), Plays a role in the initiation and/or maintenance of suckling in neonatal mice (PubMed:10359701), May also play a regulatory role in the immune system (By similarity)

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is BUB3-interacting and GLEBS motif-containing protein ZNF207 protein, from Mouse, contains 495 amino acids, has 2 C2H2-type Zinc finger.

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly, ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets, Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440), Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3, Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3, According to another report, the stabilization is independent of the proteasome (By similarity)


This is Type II restriction enzyme BslI subunit alpha protein, from Bacillus sp. (strain NEB-606), contains 225 amino acids, has 2 C4-type Zinc finger.

A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-CCN(7)GG-3' and cleaves after N-7


This is Axial regulator YABBY 4 protein, from Mouse-ear cress, contains 231 amino acids, has 1 C4-type Zinc finger.

Essential for the formation and the abaxial-adaxial asymmetric growth of the ovule outer integument


This is Zinc finger protein ZAT18 protein, from Mouse-ear cress, contains 175 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor involved in stress responses (Probable) (PubMed:28586434), Positive regulator of the jasmonic acid (JA)- mediated signaling pathway (PubMed:14973281), Triggers the up-regulation of LOX3, VSP2, PAL1 and PAL2 in a JA-dependent manner (PubMed:14973281), Promotes drought and osmotic stress tolerance by preventing reactive oxygen species (ROS) production (e,g, H(2)O(2)) (PubMed:28586434)


This is Zinc finger protein STAMENLESS 1 protein, from Rice, contains 263 amino acids, has 1 C2H2-type Zinc finger.

Regulates floral organ identity and cell proliferation in the inner floral whorls, Probably specifies the identities of lodicule and stamen through positive regulation of MADS16 expression, May contribute to morphogenesis by suppressing OSH1 expression in the lateral organs


This is Zinc-finger homeodomain protein 9 protein, from Mouse-ear cress, contains 312 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate


This is VIN3-like protein 1 protein, from Mouse-ear cress, contains 602 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Involved in both the vernalization and photoperiod pathways by regulating expression of the related floral repressors FLOWERING LOCUS C (FLC) and FLOWERING LOCUS M (FLM), Together with VIN3, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e,g, chromatin modifications, histone deacetylation, and trimethylated H3 'Lys-4' H3K4me3 and 'Lys-27' H3K27me3) and with acquisition of competence to flower, Promotes flowering in short days (SD=8 hours light/16 hours dark), Associates dynamically at FLC locus; during vernalization, binds to specific sites, but when in warm conditions, distributed along the whole locus


This is Protein FAR-RED ELONGATED HYPOCOTYL 3 protein, from Mouse-ear cress, contains 839 amino acids, has 1 SWIM-type Zinc finger.

SWIM-type

Transcription activator that recognizes and binds to the DNA consensus sequence 5'-CACGCGC-3', Activates the expression of FHY1 and FHL involved in light responses, When associated with PHYA, protects it from being recognized and degraded by the COP1/SPA complex, Positive regulator of chlorophyll biosynthesis via the activation of HEMB1 gene expression


This is Glycine-rich RNA-binding protein RZ1A protein, from Mouse-ear cress, contains 245 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Binds RNA and DNA sequences with a preference to single-stranded nucleic acids, Displays strong affinity to poly(G) and poly(U) sequences, May be involved in tolerance to cold stress


This is PHD finger protein ING1 protein, from Mouse-ear cress, contains 234 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is B-box zinc finger protein 32 protein, from Mouse-ear cress, contains 225 amino acids, has 1 B box-type; atypical Zinc finger.

B box-type; atypical

Repressor of light-mediated regulation of seedling development, Functions by suppressing the activities of positive cofactors like BBX21 and HY5 involved in modulating light-regulated gene expression and growth


This is DNA replication licensing factor MCM2 protein, from Mouse-ear cress, contains 936 amino acids, has 1 C4-type Zinc finger.

Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells, May play a crucial role in the control of de-differentiation and cell proliferation processes required for lateral root formation, Is essential for embryo development, Is involved in the geminivirus mungbean yellow mosaic virus (MYMV) DNA replication, presumably in conjunction with other host factors


This is Zinc-finger homeodomain protein 14 protein, from Mouse-ear cress, contains 168 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate


This is E3 ubiquitin-protein ligase MPSR1 protein, from Mouse-ear cress, contains 204 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in protein quality control (PQC) under proteotoxic stress, Is essential to plant survival under proteotoxic stress, Functions by removing damaged proteins before they form cytotoxic aggregates, Recognizes misfolded proteins selectively and tethers polyubiquitin chains to the proteins directly for subsequent degradation by the 26S proteasome pathway, Targets misfolded proteins independently of cytoplasmic chaperones, Associates with the 26S proteasome and sustains the structural integrity of the proteasome complex at the initial stage of proteotoxic stress, Under normal conditions, MPSR1 becomes highly unstable by its autoubiquitination activity and is stabilized during proteotoxic stress by conjugating ubiquitins on misfolded proteins


This is B-box zinc finger protein 21 protein, from Mouse-ear cress, contains 331 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Transcription activator that acts as positive regulator of seedling photomorphogenesis (PubMed:17965270), Acts downstream of COP1 and play an important role in early and long-term adjustment of the shade avoidance syndrome (SAS) responses in natural environments (PubMed:21070414)


This is E3 ubiquitin-protein ligase EL5 protein, from Rice, contains 325 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Functions as a E3 ubiquitin-protein ligase in cooperation with the E2 ubiquitin conjugating enzymes UBC5A and UBC5B, Involved in root development, Required for the maintenance of cell viability after the initiation of root primordial formation, May mediate the degradation of cytotoxic proteins produced in root cells after the actions of auxin, cytokinin and jasmonic acid, Mediates 'Lys-48'-linked polyubiquitination of MBP in vitro


This is GATA transcription factor 25 protein, from Mouse-ear cress, contains 309 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters

Belongs to the type IV zinc-finger family, Class C subfamily


This is E3 ubiquitin-protein ligase WAV3 protein, from Mouse-ear cress, contains 740 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in the regulation of root growth, Acts as positive regulator of root gravitropism, Possesses E3 protein ligase activity in vitro


This is Splicing factor-like protein 1 protein, from Mouse-ear cress, contains 804 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Necessary for the splicing of pre-mRNA, Required during development and for abscisic acid (ABA) responses


This is Protein OBERON 2 protein, from Mouse-ear cress, contains 574 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Probable transcription factor that acts together with OBE1 for the maintenance and/or establishment of both the shoot and root meristems, probably by controlling the expression of the meristem genes such as WUS, PLT1 and PLT2 and of genes required for auxin responses, Promotes cell meristematic activity via the WUSCHEL-CLAVATA pathway, Involved in the development of the basal pole and in auxin-mediated root and vascular development in the embryo, Confers sensitivity to turnip mosaic virus (TuMV) probably by promoting viral movement and multiplication via interaction with TuMV VPg


This is RING-H2 finger protein ATL63 protein, from Mouse-ear cress, contains 308 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Belongs to the RING-type zinc finger family, ATL subfamily


This is Protein INCREASED RESISTANCE TO MYZUS PERSICAE 1 protein, from Mouse-ear cress, contains 113 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is DNA topoisomerase 3-alpha protein, from Mouse-ear cress, contains 926 amino acids, has 1 C4-type Zinc finger, has 2 CCHC-type Zinc finger, has 1 GRF-type Zinc finger.

CCHC-type

GRF-type

CCHC-type

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone, Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells, Together with RMI1, is essential for the resolution of meiotic recombination intermediates, a step that prevents entanglement of the parental chromosomes, May have DNA decatenation activity

Belongs to the type IA topoisomerase family


This is Zinc finger protein ENHYDROUS protein, from Mouse-ear cress, contains 500 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor promoting the transition to germination by regulating light and hormonal signaling during seed maturation (PubMed:21571950), Acts as a positive regulator of phytochrome and/or gibberellin action (PubMed:21571950, PubMed:25035403)


This is Transcription factor KUA1 protein, from Mouse-ear cress, contains 365 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Transcriptional repressor (PubMed:23888064, PubMed:24806884), Direct regulator of the transcription of peroxidase (Prxs) and reactive oxygen species (ROS)-related genes via the recognition of 5'-ATCACA-3' motif (PubMed:24806884), Binds to 5'-TATCCA-3' motif (TA box) and represses the activity of corresponding promoters (e,g, sugar response genes) (PubMed:25920996), Regulates hypocotyl elongation in response to darkness by enhancing auxin accumulation in a phytochrome-interacting factor (PIF) proteins-dependent manner, Promotes lateral roots formation (PubMed:23888064), Promotes cell expansion during leaves development via the modulation of cell wall-located Prxs (PubMed:24806884), Plays a critical role in developmentally regulated and dark-induced onset of leaf senescence by repressing the transcription of several genes involved in chloroplast function and responses to light and auxin, Promotes responses to auxin, abscisic acid (ABA), and ethylene (PubMed:25920996)


This is E3 ubiquitin-protein ligase RING1 protein, from Mouse-ear cress, contains 301 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that may be involved in positive regulation of programmed cell death (PCD) by facilitating degradation of negative regulators of PCD, May be involved in the early steps of the plant defense signaling pathway, Undergoes auto-ubiquitination


This is Histone acetyltransferase of the MYST family 2 protein, from Mouse-ear cress, contains 445 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Histone acetyltransferase which may be involved in transcriptional activation, Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:16648464, PubMed:17877703), Essential for gametophyte development (PubMed:19040736), Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925)


This is Zinc-finger homeodomain protein 8 protein, from Mouse-ear cress, contains 271 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate


This is E3 ubiquitin-protein ligase RGLG2 protein, from Mouse-ear cress, contains 468 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains, Regulates apical dominance by acting on the auxin transport proteins abundance (PubMed:17586653), Mediates ubiquitination and subsequent proteasomal degradation of ERF053 in response to drought stress, Acts as a negative regulator of drought stress response (PubMed:22095047)


This is FCS-Like Zinc finger 10 protein, from Mouse-ear cress, contains 344 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway (PubMed:24600465), Negatively regulates KIN10 leading to a repression of the SnRK1 signaling pathway (PubMed:29406622)


This is Probable E3 ubiquitin-protein ligase LUL1 protein, from Mouse-ear cress, contains 337 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro)

Belongs to the RING-type zinc finger family, LOG2 subfamily


This is Dof zinc finger protein DOF5.1 protein, from Mouse-ear cress, contains 399 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity), Binds to 5'-TAAAGT-3' motif in REV promoter to triggers its transcription, thus regulating adaxial-abaxial polarity and influencing leaf axial patterning in an auxin transport- and response-dependent manner (e,g, IAA6 and IAA19 genes expression) (PubMed:20807212), Probably involved in early processes for vascular development (PubMed:17583520), The PEAR proteins (e,g, DOF2,4, DOF5,1, DOF3,2, DOF1,1, DOF5,6 and DOF5,3) activate gene expression that promotes radial growth of protophloem sieve elements (PubMed:30626969)


This is Histone deacetylase HDT3 protein, from Mouse-ear cress, contains 294 amino acids, has 1 C2H2-type Zinc finger.

Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Involved in the modulation of abscisic acid and stress-responsive genes

Belongs to the histone deacetylase HD2 family


This is E3 ubiquitin-protein ligase AIRP2 protein, from Mouse-ear cress, contains 242 amino acids, has 1 RING-type Zinc finger.

RING-type

Possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E2 enzyme UBC8 in vitro (PubMed:21969385, PubMed:28626006), Plays combinatory roles with AIRP1 in the positive regulation of the abscisic acid-mediated drought stress response (PubMed:21969385), Plays a positive role in abscisic acid- and high salinity-regulated seed germination through the ubiquitin-proteasome-dependent down-regulation of ATP1/SDIRIP1 (PubMed:28626006)


This is Dof zinc finger protein DOF3.2 protein, from Mouse-ear cress, contains 245 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that negatively affects seed germination and opposes TCP14 function in the regulation of a specific set of abscisic acid-related genes (PubMed:22155632), The PEAR proteins (e,g, DOF2,4, DOF5,1, DOF3,2, DOF1,1, DOF5,6 and DOF5,3) activate gene expression that promotes radial growth of protophloem sieve elements (PubMed:30626969)


This is RING-box protein 1b protein, from Mouse-ear cress, contains 115 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development, Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate (By similarity)


This is Zinc finger BED domain-containing protein DAYSLEEPER protein, from Mouse-ear cress, contains 696 amino acids, has 1 BED-type Zinc finger.

BED-type

Transposase-like protein that is essential for plant growth and development, Binds the promoter region of the DNA helicase KU70 and genes involved in chromatin remodeling, May regulate global gene expression by recruiting other cellular factors


This is E3 ubiquitin-protein ligase SINAT2 protein, from Mouse-ear cress, contains 308 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:28351989, PubMed:32786047), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:28351989, PubMed:32786047), It probably triggers the ubiquitin-mediated degradation of different substrates (PubMed:28351989, PubMed:32786047), Mediates the proteasomal-dependent degradation of ATG6, a component of the autophagosome complex (PubMed:28351989), Requires TRAF1A/MUSE14 and TRAF1B/MUSE13 to target ATG6 for ubiquitination and subsequent regulation of autophagosome assembly (PubMed:28351989), Modulates directly the ubiquitination and proteasomal-dependent degradation of FREE1, a component of the ESCRT-I complex (PubMed:32786047, PubMed:32753431), Modulates directly the ubiquitination and proteasomal-dependent degradation of ELC/VPS23A, a component of the ESCRT-I complex (PubMed:32753431)

Belongs to the SINA (Seven in absentia) family


This is E3 ubiquitin-protein ligase SDIR1 protein, from Mouse-ear cress, contains 273 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a positive regulator of abscisic acid-related stress signal transduction (PubMed:17573536, PubMed:18685183), Interacts with and ubiquitinates ATP1/SDIRIP1 to modulate ATP1/SDIRIP1 stability through the 26S proteasome pathway, Regulates abscisic acid (ABA) and salt stress responses by negatively affecting ATP1/SDIRIP1 stability, The SDIR1-ATP1/SDIRIP1 complex plays an important role in ABA signaling through the ubiquitination pathway (PubMed:25616872)


This is Protein NCA1 protein, from Mouse-ear cress, contains 405 amino acids, has 1 RING-type Zinc finger.

RING-type

Has holdase chaperone activity that may fold catalase to a functional structure (PubMed:25700484), Not required for the peroxisome import of catalases (PubMed:25700484), Required for the activity of catalases and acts mainly at the post-transcriptional level (PubMed:24285797)


This is Phragmoplastin interacting protein 1 protein, from Mouse-ear cress, contains 597 amino acids, has 3 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

RNA-binding protein which mediates polarized mRNA (e,g, Ran2 transcripts mRNA) transport from the nucleus to the vicinity of the cell plate during cytokinesis and phragmoplast formation


This is Receptor homology region, transmembrane domain- and RING domain-containing protein 1 protein, from Mouse-ear cress, contains 310 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Involved in the trafficking of vacuolar proteins, Functions probably as a sorting receptor for protein trafficking to the protein storage vacuole (PSV) by binding the C-terminal vacuolar sorting determinant (VSD) of vacuolar-sorted proteins


This is Peroxisome biogenesis protein 12 protein, from Mouse-ear cress, contains 393 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:16113209, PubMed:16813573, PubMed:17478547, PubMed:19594707, PubMed:20679226, PubMed:23336935), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is Protein ABA AND ROS SENSITIVE 1 protein, from Mouse-ear cress, contains 313 amino acids, has 1 C2H2-type Zinc finger.

Essential for breaking seed dormancy before seed germination (PubMed:26583028), Prevents reactive oxygen species (ROS) accumulation in response to abscisic acid (ABA) and oxidative stress, probably by repressing the accumulation of ABA-induced ROS-scavenging enzymes (e,g, CSD3) (PubMed:26583028)


This is Zinc-finger homeodomain protein 4 protein, from Mouse-ear cress, contains 312 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate

Putative transcription factor, Probably involved in the regulation of floral induction


This is E3 ubiquitin protein ligase DRIP1 protein, from Mouse-ear cress, contains 421 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress, Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A, Functionally redundant with DRIP2


This is B-cell receptor CD22 protein, from Pygmy chimpanzee, contains 847 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates B-cell B-cell interactions, May be involved in the localization of B-cells in lymphoid tissues, Binds sialylated glycoproteins; one of which is CD45, Preferentially binds to alpha-2,6-linked sialic acid (By similarity), Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling, Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is B-cell receptor CD22 protein, from Chimpanzee, contains 847 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Glucocorticoid receptor protein, from Pig, contains 782 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is E3 ubiquitin-protein ligase makorin protein, from Caenorhabditis elegans, contains 413 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase which catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity), Promotes the larval to adult transition by binding to the long non-coding RNA lep-5 to target the heterochronic protein lin-28 for degradation by the proteasome (PubMed:26811380, PubMed:30956008), This association and degradation of lin-28 also controls the timing of the sexual differentiation of individual neurons in males including the AIM, AWA, ADF, ASJ and CEM neurons (PubMed:31264582), Plays a role in governing the developmental timing of male tail tip morphogenesis (PubMed:26811380), Plays a role in two aspects of male mating behavior: response to hermaphrodite contact and vulva location (PubMed:26811380, PubMed:31264582), May play a role in the detection of preferred food sources (PubMed:31264582)


This is Dauer abnormal formation protein 25 protein, from Caenorhabditis elegans, contains 388 amino acids, has 1 MYND-type Zinc finger.

MYND-type

May be involved in the trafficking and dendritic transport of signaling proteins, such as the receptor-type guanylate cyclases gcy-12 and daf-11, to the cilia, In ciliated sensory neurons, required for the calcium flux to the cytoplasm in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response to NO-producing organisms like P,aeruginosa (PubMed:30014846)


This is Poly [ADP-ribose] polymerase 1 protein, from Caenorhabditis elegans, contains 945 amino acids, has 1 PARP-type Zinc finger, has 1 PARP-type 2; degenerate Zinc finger.

PARP-type

PARP-type 2; degenerate

Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death (PubMed:15923155), Involved in protection of the genome against mutations (PubMed:12600937)


This is Zinc finger protein lsy-2 protein, from Caenorhabditis elegans, contains 365 amino acids, has 5 C2H2-type Zinc finger.

Involved in transcriptional regulation (By similarity), Required to specify left-right asymmetry of the ASE gustatory neurons, probably acting upstream of microRNA lsy-6 (PubMed:16291785, PubMed:26050091), Involved in maintaining the distinction between somatic and germ cells, perhaps acting by repressing germ cell-specific genes in somatic cells (PubMed:26050091)


This is Zinc finger protein sens protein, from Fruit fly, contains 541 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS), Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation, Correct expression requires expression of scalloped (sd), Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination


This is Histone-lysine N-methyltransferase mes-4 protein, from Caenorhabditis elegans, contains 898 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Histone methyltransferase, Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation, Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage, Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes (PubMed:12077420, PubMed:16968818), Not related to transcription elongation (PubMed:12077420, PubMed:16968818), Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259), May suppress sensitivity to RNAi (PubMed:16507136), May regulate the expression of genes required for vulval development (PubMed:16507136, PubMed:16710447)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily


This is Protein vav protein, from Fruit fly, contains 793 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, Probably plays a pivotal role as a signal transducer protein during fruit fly development


This is RING-box protein 1B protein, from Fruit fly, contains 122 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity)


This is Polycomb protein Su(z)12 protein, from Fruit fly, contains 900 amino acids, has 1 C2H2-type Zinc finger.

Polycomb group (PcG) protein, While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state, Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene, The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is X-linked interleukin-1 receptor accessory protein-like 2 protein, from Human, contains 686 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is ADP-ribosylation factor GTPase-activating protein 3 protein, from Human, contains 516 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes


This is Zinc finger CCHC domain-containing protein 17 protein, from Human, contains 241 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Triggering receptor expressed on myeloid cells 1 protein, from Human, contains 234 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad


This is E3 ubiquitin-protein ligase CCNB1IP1 protein, from Human, contains 277 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase, Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase, Overexpression causes delayed entry into mitosis


This is Myoneurin protein, from Human, contains 610 amino acids, has 8 C2H2-type Zinc finger.

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Arf-GAP with dual PH domain-containing protein 2 protein, from Human, contains 381 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for the ADP ribosylation factor family (Potential), Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4), Possesses a stoichiometry of two binding sites for InsP4 with identical affinity


This is Interleukin-1 receptor accessory protein protein, from Human, contains 570 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Unable to mediate canonical IL-1 signaling (PubMed:19481478), Required for Src phosphorylation by IL1B, May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity)


This is Semaphorin-4B protein, from Human, contains 837 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons


This is SLAM family member 7 protein, from Human, contains 335 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Isoform 3 does not mediate any NK cell activation


This is E3 ubiquitin-protein ligase TRIM36 protein, from Human, contains 728 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 B box-type Zinc finger.

RING-type; degenerate

B box-type

B box-type

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins, Involved in chromosome segregation and cell cycle regulation (PubMed:28087737), May play a role in the acrosome reaction and fertilization


This is E3 ubiquitin-protein ligase Jade-2 protein, from Human, contains 790 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653), Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020), Also acts as a ubiquitin ligase E3 toward itself, Positive regulator of neurogenesis (By similarity)


This is Nectin-3 protein, from Human, contains 549 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions, Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1, Also involved in the formation of cell-cell junctions, including adherens junctions and synapses, Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation, Plays a role in the morphology of the ciliary body


This is Histone-lysine N-methyltransferase PRDM9 protein, from Human, contains 894 amino acids, has 13 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727, PubMed:27129774), Can also methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727), Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity), During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727), Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity), During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema, EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity), In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity), Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity), In addition performs automethylation (By similarity), Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is PR domain zinc finger protein 8 protein, from Human, contains 689 amino acids, has 3 C2H2-type Zinc finger.

Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity), Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity), Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity), In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity)


This is Putative histone-lysine N-methyltransferase PRDM6 protein, from Human, contains 595 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 2 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 4; degenerate

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression, Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells, Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation, It is unclear whether it has histone methyltransferase activity in vivo, According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a, According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro, 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression


This is PR domain zinc finger protein 5 protein, from Human, contains 630 amino acids, has 14 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

Sequence-specific DNA-binding transcription factor, Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1, Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes, May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2, May cause G2/M arrest and apoptosis in cancer cells


This is Zinc finger C4H2 domain-containing protein protein, from Human, contains 224 amino acids, has 1 C4H2-type Zinc finger.

Plays a role in interneurons differentiation (PubMed:26056227), Involved in neuronal development and in neuromuscular junction formation


This is Endothelial zinc finger protein induced by tumor necrosis factor alpha protein, from Human, contains 489 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein 302 protein, from Human, contains 478 amino acids, has 7 C2H2-type Zinc finger.


This is Muscleblind-like protein 1 protein, from Human, contains 388 amino acids, has 4 C3H1-type Zinc finger.

Mediates pre-mRNA alternative splicing regulation, Acts either as activator or repressor of splicing on specific pre-mRNA targets, Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle, Antagonizes the alternative splicing activity pattern of CELF proteins, Regulates the TNNT2 exon 5 skipping through competition with U2AF2, Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA, Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly, Binds to the 5'-YGCU(U/G)Y-3'consensus sequence, Binds to the IR RNA, Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues


This is SLC2A4 regulator protein, from Human, contains 387 amino acids, has 1 C2H2-type Zinc finger.

Transcription factor involved in SLC2A4 and HD gene transactivation, Binds to the consensus sequence 5'-GCCGGCG-3'


This is N-lysine methyltransferase SMYD2 protein, from Human, contains 433 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'


This is Ras association domain-containing protein 1 protein, from Human, contains 344 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Potential tumor suppressor, Required for death receptor-dependent apoptosis, Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation, When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation, Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression, Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein, Isoform C has been shown not to perform these roles, no function has been identified for this isoform, Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage


This is E3 ubiquitin-protein ligase RAD18 protein, from Human, contains 495 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA, Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA, Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164', Has ssDNA binding activity


This is Zinc finger protein 275 protein, from Human, contains 429 amino acids, has 11 C2H2-type Zinc finger.


This is Leucine-rich repeat-containing protein 4B protein, from Human, contains 713 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Synaptic adhesion protein, Regulates the formation of excitatory synapses, The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity)


This is Semaphorin-4G protein, from Human, contains 838 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB2, May play a role in axon guidance (By similarity)


This is Zinc finger protein 64 protein, from Human, contains 645 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

May be involved in the regulation of mesenchymal cell differentiation through transactivation of NOTCH1 target genes


This is E3 ubiquitin-protein ligase RNF146 protein, from Human, contains 359 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation (PubMed:21478859, PubMed:21799911, PubMed:22267412), May regulate many important biological processes, such as cell survival and DNA damage response (PubMed:21825151, PubMed:22267412), Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex (PubMed:21478859, PubMed:21799911), Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2 (PubMed:21799911), Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation (PubMed:21799911), Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48' (PubMed:21799911), May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location (PubMed:21799911), Neuroprotective protein (PubMed:21602803), Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity), Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity), Does not affect PARP1 activation (By similarity), Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity), Promotes cell survival after gamma-irradiation (PubMed:21825151), Facilitates DNA repair (PubMed:21825151)


This is Zinc finger protein 57 homolog protein, from Human, contains 452 amino acids, has 6 C2H2-type Zinc finger, has 1 C2H2-type 7; degenerate Zinc finger.

C2H2-type 7; degenerate

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation, Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440), Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance, In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440), Required for the establishment of maternal methylation imprints at SNRPN locus, Acts as a transcriptional repressor in Schwann cells, Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family, ZFP57 subfamily


This is Zinc finger CCHC domain-containing protein 3 protein, from Human, contains 403 amino acids, has 3 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424), Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424), Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424), Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424), Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (PubMed:30193849)


This is Muscleblind-like protein 3 protein, from Human, contains 354 amino acids, has 4 C3H1-type Zinc finger.

Mediates pre-mRNA alternative splicing regulation, Acts either as activator or repressor of splicing on specific pre-mRNA targets, Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle, Antagonizes the alternative splicing activity pattern of CELF proteins, May play a role in myotonic dystrophy pathophysiology (DM), Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction


This is E3 ubiquitin-protein ligase RNF19A protein, from Human, contains 838 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR, Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection

Belongs to the RBR family, RNF19 subfamily


This is THAP domain-containing protein 1 protein, from Human, contains 213 amino acids, has 1 THAP-type Zinc finger.

THAP-type

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression, Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1, Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1, May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis


This is E3 ubiquitin-protein ligase RLIM protein, from Human, contains 624 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex, Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM, Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1, By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals


This is E3 ubiquitin-protein ligase FANCL protein, from Human, contains 375 amino acids, has 1 RING-type Zinc finger.

RING-type

Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026), Also mediates monoubiquitination of FANCI (PubMed:19589784), May stimulate the ubiquitin release from UBE2W, May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth


This is Pre-mRNA-splicing factor RBM22 protein, from Human, contains 420 amino acids, has 1 C3H1-type Zinc finger.

Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30705154), Involved in the first step of pre-mRNA splicing, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle, Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses


This is E3 ubiquitin-protein ligase RNF216 protein, from Human, contains 866 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome, Promotes degradation of TRAF3, TLR4 and TLR9, Contributes to the regulation of antiviral responses, Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production, Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B, Promotes TNF and RIP mediated apoptosis


This is Box C/D snoRNA protein 1 protein, from Human, contains 470 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis


This is Zinc finger protein 446 protein, from Human, contains 450 amino acids, has 3 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is E3 ubiquitin-protein ligase MARCHF5 protein, from Human, contains 278 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission, May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control, Promotes ubiquitination of FIS1, DNM1L and MFN1


This is Cell growth-regulating nucleolar protein protein, from Human, contains 379 amino acids, has 2 C2HC LYAR-type Zinc finger.

C2HC LYAR-type

C2HC LYAR-type

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227), Also acts at the level of transcription regulation, Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918), In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580), Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918), Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131), In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (PubMed:31413131), Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity), Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity)


This is Zinc finger and SCAN domain-containing protein 32 protein, from Human, contains 697 amino acids, has 6 C2H2-type Zinc finger.


This is tRNA (guanine(26)-N(2))-dimethyltransferase protein, from Human, contains 659 amino acids, has 1 C3H1-type Zinc finger.

Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

Belongs to the class I-like SAM-binding methyltransferase superfamily, Trm1 family


This is E3 ubiquitin-protein ligase RNF186 protein, from Human, contains 227 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122), Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122), Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens, Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR (PubMed:34623328), Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3, Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498), Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity (PubMed:31586034)


This is Inhibitor of growth protein 3 protein, from Human, contains 418 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair, NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage, Component of a SWR1-like complex that specifically mediates the removal of histone H2A,Z/H2AZ1 from the nucleosome


This is Sodium channel subunit beta-3 protein, from Human, contains 215 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Modulates channel gating kinetics, Causes unique persistent sodium currents, Inactivates the sodium channel opening more slowly than the subunit beta-1, Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity)

Belongs to the sodium channel auxiliary subunit SCN3B (TC 8,A,17) family


This is Anaphase-promoting complex subunit 11 protein, from Human, contains 84 amino acids, has 1 RING-type Zinc finger.

RING-type

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, May recruit the E2 ubiquitin-conjugating enzymes to the complex


This is TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 protein, from Human, contains 693 amino acids, has 1 RanBP2-type Zinc finger.

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:33184450, PubMed:36681779), Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122), The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122), Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity), Involved in heart development (PubMed:20493459)


This is RB-associated KRAB zinc finger protein protein, from Human, contains 714 amino acids, has 15 C2H2-type Zinc finger, has 1 C2H2-type 10; degenerate Zinc finger.

C2H2-type 10; degenerate

May repress E2F-dependent transcription, May promote AR-dependent transcription


This is Sialic acid-binding Ig-like lectin 8 protein, from Human, contains 499 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619), Preferentially binds to alpha-2,3-linked sialic acid, Also binds to alpha-2,6-linked sialic acid, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619), Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose, Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658)


This is Triggering receptor expressed on myeloid cells 2 protein, from Human, contains 230 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849), Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356), Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity), Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018), Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (PubMed:29794134), Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity), Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881), Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity), Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity), It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity), During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity), Plays a role in microglial MTOR activation and metabolism (By similarity), Regulates age-related changes in microglial numbers (PubMed:29752066), Triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849), Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity), In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640), Involved in the positive regulation of osteoclast differentiation (PubMed:12925681)


This is Zinc finger protein 224 protein, from Human, contains 707 amino acids, has 17 C2H2-type Zinc finger, has 1 C2H2-type 14; degenerate Zinc finger.

C2H2-type 14; degenerate

May be involved in transcriptional regulation as a transcriptional repressor, The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells


This is Interleukin-1 receptor accessory protein-like 1 protein, from Human, contains 696 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849), May activate the MAP kinase JNK (PubMed:15123616), Plays a role in neurite outgrowth (By similarity), During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity)

Belongs to the interleukin-1 receptor family


This is Programmed cell death 1 ligand 1 protein, from Human, contains 290 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410), The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity), The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity)

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Bifunctional apoptosis regulator protein, from Human, contains 450 amino acids, has 1 RING-type Zinc finger.

RING-type

Apoptosis regulator, Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors


This is Zinc finger imprinted 2 protein, from Human, contains 527 amino acids, has 5 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase KCMF1 protein, from Human, contains 381 amino acids, has 1 ZZ-type Zinc finger, has 1 C2H2-type Zinc finger.

ZZ-type

Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination


This is Zinc finger protein with KRAB and SCAN domains 7 protein, from Human, contains 754 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 11; degenerate Zinc finger.

C2H2-type 11; degenerate

May be involved in transcriptional regulation


This is E3 ubiquitin-protein ligase MARCHF2 protein, from Human, contains 246 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

(Microbial infection) Positively regulates the degradation of Vesicular stomatitis virus (VSV) G protein via the lysosomal degradation pathway (PubMed:29573664), Represses HIV-1 viral production and may inhibit the translocation of HIV-1 env to the cell surface, resulting in decreased viral cell-cell transmission (PubMed:29573664)


This is E3 ubiquitin-protein ligase RNF181 protein, from Human, contains 153 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:18331836), Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1 (PubMed:24811749)


This is Zinc finger protein 581 protein, from Human, contains 197 amino acids, has 4 C2H2-type Zinc finger.


This is CXXC-type zinc finger protein 1 protein, from Human, contains 656 amino acids, has 1 PHD-type Zinc finger, has 1 CXXC-type Zinc finger.

PHD-type

CXXC-type

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG


This is SLAM family member 8 protein, from Human, contains 285 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor


This is GEM-interacting protein protein, from Human, contains 970 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Stimulates, in vitro and in vivo, the GTPase activity of RhoA


This is Neurotrimin protein, from Human, contains 344 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, IgLON family


This is DNA-directed RNA polymerase I subunit RPA12 protein, from Human, contains 126 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I which synthesizes ribosomal RNA precursors

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is Signal-regulatory protein gamma protein, from Human, contains 387 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Ig-like C1-type

Probable immunoglobulin-like cell surface receptor, On binding with CD47, mediates cell-cell adhesion, Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation


This is Calcium-binding and coiled-coil domain-containing protein 1 protein, from Human, contains 691 amino acids, has 1 UBZ1-type Zinc finger.

Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG), Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth


This is Vacuolar protein sorting-associated protein 18 homolog protein, from Human, contains 973 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways, Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion, The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes, The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203), Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203), Involved in dendrite development of Pukinje cells (By similarity)


This is Prostaglandin F2 receptor negative regulator protein, from Human, contains 879 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant, Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity), In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity)


This is E3 ubiquitin-protein ligase MARCHF4 protein, from Human, contains 410 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Zinc finger protein 319 protein, from Human, contains 582 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 7; degenerate Zinc finger, has 1 C2H2-type 11; degenerate Zinc finger, has 1 C2H2-type 13; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 7; degenerate

C2H2-type 11; degenerate

C2H2-type 13; degenerate


This is Zinc finger protein 219 protein, from Human, contains 722 amino acids, has 9 C2H2-type Zinc finger.

Transcriptional regulator (PubMed:14621294, PubMed:19549071), Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294), Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294), Regulates SNCA expression in primary cortical neurons (PubMed:19549071), Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity), Plays a role in chondrocyte differentiation (By similarity)


This is E3 ubiquitin-protein ligase dbl4 protein, from Fission yeast, contains 504 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones, Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation


This is E3 ubiquitin-protein ligase pep5 protein, from Fission yeast, contains 906 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole, Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes, Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion, HOPS is an effector for the vacuolar Rab GTPase ypt7 and is required for vacuolar SNARE complex assembly, It remains bound to SNARE complexes after vacuole fusion, Acts as component of the CORVET complex that is required for transport between endosome and vacuole, CORVET is an effector for the endosomal Rab GTPase ypt5, Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones, Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation


This is Transcription factor IIIB 60 kDa subunit protein, from Fission yeast, contains 492 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase III transcription


This is Transcriptional adapter 2 protein, from Fission yeast, contains 437 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA, SAGA is involved in RNA polymerase II-dependent transcriptional regulation, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation, SLIK is proposed to have partly overlapping functions with SAGA, It preferentially acetylates methylated histone H3, ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (By similarity), Required for full activation of chromatin alteration and meiotic recombination at meiotic recombination hot spot ade6-M26, Also required for the regulation of transcription and chromatin structure around ade6-M26 in response to osmotic stress, Needed for hyperacetylation of histone H3 around ade6-M26


This is Structure-specific endonuclease subunit slx1 protein, from Fission yeast, contains 271 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA, Has a preference for stem-loop (SL) and splayed arm Y structures, Introduces a single-strand cut in duplex DNA on the 3' side of a double-strand/single-strand junction with respect to the single-strand moving 3' to 5' away from the junction, Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks, The complex initiates homologous recombination (HR) events, used to maintain rDNA copy number, in the rDNA repeats that are processed by a mechanism that requires rad22, but not rhp51, It is also required for suppression of methyl methanesulfonate (MMS) and UV-C irradiation hypersensitivity of the structural maintenance of chromosome (SMC) protein mutant, smc6-74, by overexpression of brc1, Has Holliday junction resolvase activity in vitro


This is Linear element-associated protein hop1 protein, from Fission yeast, contains 528 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Facilitates initiation of meiotic recombination and DNA double-strand break (DSB) formation at DSB hotspot sites by enhancing the interaction between rec10 and rec15


This is Vitamin D3 receptor A protein, from Zebrafish, contains 453 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells, Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR, The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes, Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association, Plays a central role in calcium homeostasis

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Thyroid hormone receptor beta protein, from Zebrafish, contains 395 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for the thyroid gland hormone triiodothyronine (T3), Transactivating activity is ligand-dependent, and is repressed in the absence of T3


This is Gag polyprotein protein, from HIV-1, contains 498 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Gag polyprotein protein, from HIV-1, contains 495 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-1, contains 496 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-1, contains 492 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-1, contains 491 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is DNA polymerase kappa protein, from Mouse, contains 852 amino acids, has 2 UBZ4-type Zinc finger.

DNA polymerase specifically involved in DNA repair, Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:12432099), Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts, Lacks 3'-5' proofreading exonuclease activity, Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity)

Belongs to the DNA polymerase type-Y family


This is RAS guanyl-releasing protein 2 protein, from Mouse, contains 608 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP, May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS, Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation, May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway


This is Signaling lymphocytic activation molecule protein, from Mouse, contains 343 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

(Microbial infection) Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulated of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396, PubMed:22493499)


This is Semaphorin-7A protein, from Mouse, contains 664 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses, Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3, Promotes production of pro-inflammatory cytokines by monocytes and macrophages, Plays an important role in modulating inflammation and T-cell-mediated immune responses, Promotes axon growth in the embryonic olfactory bulb, Promotes attachment, spreading and dendrite outgrowth in melanocytes


This is Nuclear receptor subfamily 1 group I member 3 protein, from Rat, contains 358 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes, Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity)


This is Probable E3 ubiquitin-protein ligase MID2 protein, from Mouse, contains 705 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; degenerate

B box-type

E3 ubiquitin ligase that plays a role in microtubule stabilization, Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons, This ubiquitination inhibits LRRK2 kinase activation by RAB29


This is Transcription elongation factor A protein 2 protein, from Mouse, contains 299 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus


This is Polyhomeotic-like protein 2 protein, from Mouse, contains 850 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility


This is Nuclear receptor subfamily 5 group A member 2 protein, from Rat, contains 560 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis, Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism, Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex, Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver, May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development (By similarity), Activates the transcription of CYP2C38 (By similarity)

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is Zinc finger protein neuro-d4 protein, from Mouse, contains 387 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor, Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth


This is E3 ubiquitin-protein ligase RAD18 protein, from Mouse, contains 509 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA, Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA, Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164', Has ssDNA binding activity


This is Activating signal cointegrator 1 protein, from Mouse, contains 581 amino acids, has 1 C4-type Zinc finger.

Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription, May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions, Plays a role in thyroid hormone receptor and estrogen receptor transactivation (By similarity), Also involved in androgen receptor transactivation (PubMed:12077347), Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1, Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B, May play a role in the development of neuromuscular junction (By similarity), May play a role in late myogenic differentiation (PubMed:27008887), Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (By similarity)


This is E3 ubiquitin-protein ligase makorin-1 protein, from Mouse, contains 481 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, These substrates include FILIP1, p53/TP53, CDKN1A and TERT, Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions, Acts as a negative regulator of telomerase (By similarity), Has negative and positive effects on RNA polymerase II-dependent transcription


This is Inhibitor of growth protein 1 protein, from Mouse, contains 279 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein, Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor


This is FMR1-interacting protein NUFIP1 protein, from Mouse, contains 484 amino acids, has 1 C2H2-type Zinc finger.


This is Photoreceptor-specific nuclear receptor protein, from Mouse, contains 395 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor of retinal photoreceptor cells, Transcriptional factor that is an activator of rod development and repressor of cone development, Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit, Enhances rhodopsin expression, Represses M- and S-cone opsin expression

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Zinc finger protein SNAI3 protein, from Mouse, contains 287 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 5; degenerate

Seems to inhibit myoblast differentiation, Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes, Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'

Belongs to the snail C2H2-type zinc-finger protein family


This is Zinc finger protein PLAG1 protein, from Mouse, contains 499 amino acids, has 7 C2H2-type Zinc finger.

Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed, Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction, Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas, Cooperates with CBFB-MYH11


This is B-cell lymphoma/leukemia 11A protein, from Mouse, contains 773 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor (By similarity), Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491), Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes (By similarity), May play a role in hematopoiesis (PubMed:10757802), Essential factor in lymphopoiesis, required for B-cell formation in fetal liver (PubMed:12717432), May function as a modulator of the transcriptional repression activity of NR2F2 (PubMed:10744719)


This is RING finger protein 11 protein, from Mouse, contains 154 amino acids, has 1 RING-type Zinc finger.

RING-type

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways, Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains, This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B, Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome