This is Protein DBF4 homolog A protein, from Mouse, contains 663 amino acids, has 1 DBF4-type Zinc finger.

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role DNA in replication and cell proliferation, Required for progression of S phase, The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle


This is Zinc finger and BTB domain-containing protein 7A protein, from Rat, contains 569 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (By similarity) (PubMed:10477728), Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity) (PubMed:10477728), Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms, That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity), Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity), Also directly interacts with transcription factors like SP1 to prevent their binding to DNA, Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation, Involved in the switch between fetal and adult globin expression during erythroid cells maturation, Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (By similarity), Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene, Efficiently abrogates E2F1-dependent CDKN2A transactivation, Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity), Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis, Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity), Plays a key role in the differentiation of lymphoid progenitors into B and T lineages, Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity), Also regulates osteoclast differentiation (PubMed:10477728), May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ, Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity), May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity)


This is Nuclear receptor subfamily 4 group A member 3 protein, from Mouse, contains 627 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner (PubMed:12709428), Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity), Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation, Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (PubMed:21868379), Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression, In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity), Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner (PubMed:24806827), During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (PubMed:11784868), Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance (PubMed:20566846, PubMed:15456880), Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation, Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (PubMed:19153266), Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (PubMed:20558821), In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (PubMed:24586680), Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1 (PubMed:23897430, PubMed:19523439), Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (PubMed:18325999), Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (By similarity), Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration (PubMed:13129926), Inhibits adipogenesis (PubMed:18945812), Also participates in cardiac hypertrophy by activating PARP1 (By similarity)

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is BRCA1-associated RING domain protein 1 protein, from Rat, contains 768 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability, Plays a central role in the control of the cell cycle in response to DNA damage, Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function, Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage


This is Estrogen receptor protein, from Golden hamster, contains 595 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP, Can activate the transcriptional activity of TFF1, Also mediates membrane-initiated estrogen signaling involving various kinase cascades, Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity)

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is PR domain zinc finger protein 4 protein, from Rat, contains 798 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger.

C2H2-type 6; degenerate

May function as a transcription factor involved in cell differentiation

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is E3 ubiquitin-protein ligase RNF25 protein, from Mouse, contains 456 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity), Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (By similarity), RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (By similarity), Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (By similarity), Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (PubMed:10500182, PubMed:18757723), May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (By similarity)


This is E3 ubiquitin-protein ligase RNF4 protein, from Mouse, contains 194 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:20681948), Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (By similarity), Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (By similarity), Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (By similarity), Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (By similarity), Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (By similarity)


This is E3 ubiquitin-protein ligase AMFR protein, from Mouse, contains 643 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:16987818, PubMed:18216283), Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:16987818, PubMed:18216283), The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:22863805), In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (By similarity), The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction (By similarity), In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (By similarity), Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (By similarity), Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (By similarity), Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (By similarity), Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (By similarity), Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:12650607), In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040), Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (By similarity)


This is Four and a half LIM domains protein 3 protein, from Mouse, contains 289 amino acids, has 1 C4-type Zinc finger.

Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1


This is Coxsackievirus and adenovirus receptor homolog protein, from Rat, contains 365 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity, Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes, The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair, Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases, It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair (By similarity)


This is Zinc finger protein 346 protein, from Mouse, contains 294 amino acids, has 4 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

Matrin-type

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (By similarity) (PubMed:10488071), May bind to specific miRNA hairpins (By similarity)


This is Guanine nucleotide exchange factor VAV3 protein, from Mouse, contains 847 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1, Binds physically to the nucleotide-free states of those GTPases (By similarity), Plays an important role in angiogenesis, Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly, May be important for integrin-mediated signaling, at least in some cell types, In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function, This signaling pathway involves RAC1, but not RHO, activation, Necessary for proper wound healing, In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils, Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion, Does not affect integrin beta-1-mediated adhesion


This is E3 ubiquitin-protein ligase XIAP protein, from Rat, contains 496 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis, Acts as a direct caspase inhibitor, Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry, Inactivates CASP9 by keeping it in a monomeric, inactive state, Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin, Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling, 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2, Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation, Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation, Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation, Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation, Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation, Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis, Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner, Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8, Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES, Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program


This is A-kinase anchor protein 8-like protein, from Mouse, contains 642 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9, Increases CTE-dependent nuclear unspliced mRNA export, Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA, May be involved in nuclear envelope breakdown and chromatin condensation, May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis, May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta, Required for cell cycle G2/M transition and histone deacetylation during mitosis, In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8, May be involved in regulation of pre-mRNA splicing (By similarity)


This is Synaptotagmin-like protein 4 protein, from Mouse, contains 673 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary, Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner


This is Metastasis-associated protein MTA2 protein, from Mouse, contains 668 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

May function as a transcriptional coregulator (By similarity), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity)


This is Nuclear receptor subfamily 1 group I member 2 protein, from Rat, contains 431 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds, Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs, Response to specific ligands is species-specific, due to differences in the ligand-binding domain, Activated by naturally occurring steroids, such as pregnenolone and progesterone, Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is E3 ubiquitin-protein ligase COP1 protein, from Mouse, contains 733 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Involved in JUN ubiquitination and degradation, Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis, Ubiquitinates p53 independently of MDM2 or RCHY1, Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes, In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1, Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival, Ubiquitinates MTA1 leading to its proteasomal degradation, Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif


This is Diacylglycerol kinase epsilon protein, from Mouse, contains 564 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11287665), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11287665), Also plays an important role in the biosynthesis of complex lipids (By similarity), Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:11287665, PubMed:19744926), Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (By similarity)

Belongs to the eukaryotic diacylglycerol kinase family


This is Transcriptional repressor CTCF protein, from Rat, contains 737 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 11; atypical Zinc finger.

C2H2-type 11; atypical

Chromatin binding factor that binds to DNA sequence specific sites, Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers, Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene, Also binds to the PLK and PIM1 promoters, Acts as a transcriptional activator of APP, Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression, Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription, Seems to act as tumor suppressor, Plays a critical role in the epigenetic regulation, Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus, On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2, Plays a critical role in gene silencing over considerable distances in the genome, Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones, Inversely, binding to target sites is prevented by CpG methylation, Plays an important role in chromatin remodeling, Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping, Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory, Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription, When bound to chromatin, it provides an anchor point for nucleosomes positioning, Seems to be essential for homologous X-chromosome pairing, May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation, May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation, Involved in sister chromatid cohesion, Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites, Regulates asynchronous replication of IGF2/H19, Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis

Belongs to the CTCF zinc-finger protein family


This is RAS guanyl-releasing protein 1 protein, from Rat, contains 795 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:9789079, PubMed:9582122), Activates the Erk/MAP kinase cascade, Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras, Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity), Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses, May also function in differentiation of other cell types, Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (By similarity)


This is Tripartite motif-containing protein 3 protein, from Mouse, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:24086586, PubMed:26527743), In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation (By similarity), Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (PubMed:26527743), Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity), Positively regulates motility of microtubule-dependent motor protein KIF21B (PubMed:24086586), Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A, Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:26527743), In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity)


This is Inducible T-cell costimulator protein, from Rat, contains 200 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells, Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens, Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10, Prevents the apoptosis of pre-activated T-cells, Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)


This is Hypermethylated in cancer 1 protein protein, from Mouse, contains 733 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional repressor (PubMed:18347096), Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (By similarity), May act as a tumor suppressor (PubMed:16269335, PubMed:18347096), Involved in development of head, face, limbs and ventral body wall (PubMed:10655551), Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335), The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (By similarity), In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (By similarity), Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (By similarity), Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (By similarity), Probably represses transcription from ACKR3, FGFBP1 and EFNA1 (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family, Hic subfamily


This is Tapasin protein, from Mouse, contains 465 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)


This is Splicing factor U2af small subunit A protein, from Mouse-ear cress, contains 296 amino acids, has 2 C3H1-type Zinc finger.

Necessary for the splicing of pre-mRNA (By similarity), Probably active at the 3' splice sites

Belongs to the splicing factor SR family


This is Protein OBERON 1 protein, from Mouse-ear cress, contains 566 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Probable transcription factor that acts together with OBE2 for the maintenance and/or establishment of both the shoot and root meristems, probably by controlling the expression of the meristem genes such as WUS, PLT1 and PLT2 and of genes required for auxin responses, Promotes cell meristematic activity via the WUSCHEL-CLAVATA pathway, Involved in the development of the basal pole and in auxin-mediated root and vascular development in the embryo, Confers sensitivity to turnip mosaic virus (TuMV) probably by promoting viral movement and multiplication via interaction with TuMV VPg


This is Probable E3 ubiquitin-protein ligase LOG2 protein, from Mouse-ear cress, contains 388 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro), Required for GLUTAMINE DUMPER 1(GDU1)-induced amino acid secretion and for amino acid homeostasis, Ubiquitinates GDU1 (in vitro)

Belongs to the RING-type zinc finger family, LOG2 subfamily


This is E3 ubiquitin-protein ligase RGLG4 protein, from Mouse-ear cress, contains 401 amino acids, has 1 RING-type Zinc finger.

RING-type

Possesses E3 ubiquitin-protein ligase in vitro, Acts as upstream modulator of jasmonate (JA) signaling in response to various stimuli, such as JA-inhibited root growth, JA-inductive gene expression, coronatine-mediated pathogen susceptibility, wound-stimulated expression of JA-responsive genes and wound-induced JA biosynthesis (PubMed:22898498), Controls fumonisin B1 (FB1)-triggered programmed cell death (PCD) by modulating the JA signaling pathway, May mediate salicylic acid (SA) suppression of JA signaling in FB1-induced responses (PubMed:25788731), May mediate the formation of 'Lys-48'-linked multiubiquitin chains, Mediates the polyubiquitination and subsequent proteasomal degradation of the target protein GRXS17 (PubMed:27497447)


This is Zinc-finger homeodomain protein 2 protein, from Mouse-ear cress, contains 220 amino acids, has 1 ZF-HD dimerization-type Zinc finger.

ZF-HD dimerization-type

Essential protein, Putative transcription factor


This is Protein NBR1 homolog protein, from Mouse-ear cress, contains 704 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Autophagic substrate degraded in the vacuole by non-selective autophagy, Requires ATG8 protein expression to be recognized as an autophagic substrate (PubMed:21606687), Acts probably as a receptor for autophagosomal degradation of ubiquitinated proteins, Targets ubiquitinated protein aggregates derived from denatured or damaged non-native proteins generated under stress conditions (PubMed:23341779), Functions additively with the E3 ubiquitin-protein ligase CHIP for autophagosomal degradation of proteotoxic aggregates formed under stress conditions (PubMed:24497840)


This is Zinc finger protein GAI-ASSOCIATED FACTOR 1 protein, from Mouse-ear cress, contains 452 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling, GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins


This is Zinc-finger homeodomain protein 11 protein, from Mouse-ear cress, contains 242 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate

Transcription factor involved in the up-regulation of several stress-inducible genes, Acts as a transcriptional activator by interacting with MED25 and NAC proteins, Involved in increased drought tolerance


This is Probable DNA helicase MCM8 protein, from Mouse-ear cress, contains 801 amino acids, has 1 C4-type Zinc finger.

Probable DNA helicase that plays a role in meiotic double-strand break (DSB) repair, but seems not required for recombination with the homologous chromosome, May be involved with RAD51 in a backup pathway that repairs meiotic DSB without giving meiotic crossover, in parallel to the meiotic homologous recombination which relies on DMC1


This is Transcriptional adapter ADA2a protein, from Mouse-ear cress, contains 548 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Required for the function of some acidic activation domains, which activate transcription from a distant site, The exact mechanism of action is not yet known (By similarity), ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region


This is Transcription factor VOZ1 protein, from Mouse-ear cress, contains 486 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical

Transcriptional activator acting positively in the phytochrome B signaling pathway, Functions redundantly with VOZ2 to promote flowering downstream of phytochrome B (phyB), Down-regulates 'FLOWERING LOCUS C' (FLC) and up-regulates 'FLOWERING LOCUS T' (FT), Binds to the 38-bp cis-acting region of the AVP1 gene, Interacts with phyB in the cytoplasm and is translocated to the nucleus at signal transmission, where it is subjected to degradation in a phytochrome-dependent manner


This is FCS-Like Zinc finger 6 protein, from Mouse-ear cress, contains 162 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway (PubMed:24600465), Negatively regulates KIN10 leading to a repression of the SnRK1 signaling pathway (PubMed:29406622)


This is Probable E3 ubiquitin-protein ligase XERICO protein, from Mouse-ear cress, contains 162 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Function on abscisic acid homeostasis at post-translational level, probably through ubiquitin/proteasome-dependent substrate-specific degradation


This is B-box zinc finger protein 25 protein, from Mouse-ear cress, contains 238 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Acts as negative regulator of seedling photomorphogenesis (PubMed:18540109), BBX25/STH and BBX24/STO function as transcriptional corepressors of HY5 activity, leading to the down-regulation of BBX22 expression, BBX25/STH acts additively with BBX24/STO during de-etiolation and the hypocotyl shade avoidance response (PubMed:23624715)


This is Vacuolar protein-sorting-associated protein 11 homolog protein, from Mouse-ear cress, contains 932 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment


This is B-box zinc finger protein 18 protein, from Mouse-ear cress, contains 172 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Acts as negative regulator of seedling photomorphogenesis (PubMed:18540109), Acts as a negative regulator of blue light-mediated inhibition of hypocotyl elongation through increase of bioactive gibberellin levels (PubMed:20872270), Acts as a repressor of thermotolerance by modulating expression of a set of heat shock-responsive genes (PubMed:23238922)


This is Replication protein A 70 kDa DNA-binding subunit A protein, from Mouse-ear cress, contains 640 amino acids, has 1 C4-type Zinc finger.

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication, The activity of RPA is mediated by single-stranded DNA binding and protein interactions, Plays an essential role at later stages of meiotic recombination events required for the formation of class I crossovers, Is essential for normal progression through meiosis in pollen mother cells, Is involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses, but does not seem to be required for the repair of meiotic DSBs

Belongs to the replication factor A protein 1 family


This is Transcription factor VOZ2 protein, from Mouse-ear cress, contains 450 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical

Transcriptional activator acting positively in the phytochrome B signaling pathway, Functions redundantly with VOZ1 to promote flowering downstream of phytochrome B (phyB), Down-regulates 'FLOWERING LOCUS C' (FLC) and up-regulates 'FLOWERING LOCUS T' (FT), Binds to the 38-bp cis-acting region of the AVP1 gene, Binds as a dimer to the palindromic sequence 5'-GCGTNNNNNNNACGC-3', Interacts with phyB in the cytoplasm and is translocated to the nucleus at signal transmission, where it is subjected to degradation in a phytochrome-dependent manner


This is Squamosa promoter-binding-like protein 1 protein, from Mouse-ear cress, contains 881 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3' of AP1 promoter, Binds specifically to the 5'-GTAC-3' core sequence


This is Protein BUNDLE SHEATH DEFECTIVE 2, chloroplastic protein, from Mouse-ear cress, contains 136 amino acids, has 1 CR-type Zinc finger.

CR-type

Chloroplast chaperone required for RuBisCo biogenesis and translational regulation of the RuBisCo large subunit (RbcL) (PubMed:29217567), Stabilizes an end-state assembly intermediate of eight RbcL subunits until the small subunits (RBCSs) become available to produce a complete stable RuBisCo complex containing eight small and eight large subunits (PubMed:29217567)


This is E3 ubiquitin-protein ligase RDUF1 protein, from Mouse-ear cress, contains 395 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid-dependent drought stress responses (PubMed:22405823), Involved in the positive regulation of responses to salt and osmotic stresses during seed germination and early seedling development (PubMed:23951086), Possesses E3 ubiquitin ligase activity in vitro (PubMed:22405823, PubMed:23951086)


This is E3 ubiquitin-protein ligase CIP8 protein, from Mouse-ear cress, contains 334 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, Probably forms a minimal ubiquitin ligase complex in cooperation with the E2 enzyme UBC8, Its interaction with COP1 suggests that it may participate in proteasome-mediated degradation of HY5 in vivo


This is E3 ubiquitin-protein ligase NLA protein, from Mouse-ear cress, contains 335 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates E2-dependent protein ubiquitination (PubMed:17355433), Plays a role in salicylic acid-mediated negative feedback regulation of salicylic acid (SA) accumulation (PubMed:18753285), May be involved in the overall regulation of SA, benzoic acid and phenylpropanoid biosynthesis (PubMed:18753285), Involved in defense response (PubMed:35839945), May act as negative regulator of resistance to the necrotrophic fungal pathogen Plectosphaerella cucumerina by modulating the accumulation of the phytoalexin camalexin and the salicylic acid- and jasmonate- dependent defense pathways (PubMed:35839945), Controls the adaptability to nitrogen limitation by channeling the phenylpropanoid metabolic flux to the induced anthocyanin synthesis (PubMed:17355433, PubMed:18552353), Involved in the regulation of inorganic phosphate (Pi) homeostasis in a nitrate-dependent fashion (PubMed:21455488), Directs the ubiquitination and subsequent degradation of the plasma membrane-localized inorganic phosphate transporters PHT1-1 and PHT1-4, to maintain phosphate homeostasis (PubMed:24122828), The ubiquitination of PHTs triggers their clathrin-dependent endocytosis and trafficking to the vacuole through the endosomal pathway for degradation (PubMed:24122828), Functions cooperatively with UBC24/PHO2 to regulate the abundance of PHT1-1, PHT1-2 and PHT1-3 in different subcellular compartments (PubMed:24122828), Regulates Pi homeostasis by mediating, cooperatively with UBC24/PHO2, polyubiquitination of PHT1-4 and its targeting for degradation (PubMed:24474629), Directs the polyubiquitination and subsequent degradation of the plasma membrane-localized nitrate transporter NPF2,13/NRT1,7, to help plants to adapt to nitrogen deficiency by regulating the source-to-sink remobilization of nitrate (PubMed:28032637), Regulates leaf senescence during nitrogen deficiency by mediating, cooperatively with UBC24/PHO2, polyubiquitination of NAC92/ORE1 and its targeting for degradation (PubMed:30374089)


This is E3 ubiquitin-protein ligase RGLG1 protein, from Mouse-ear cress, contains 489 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains, Regulates apical dominance by acting on the auxin transport proteins abundance (PubMed:17586653), Together with RGLG5, mediates the ubiquitination and subsequent proteasomal degradation of the target protein PP2CA, Functions as positive regulator of abscisic acid (ABA) signaling through ABA-dependent degradation of PP2CA, a major inhibitor of ABA signaling (PubMed:27577789), Acts as a negative regulator of drought stress response (PubMed:22095047)


This is Zinc finger protein AZF2 protein, from Mouse-ear cress, contains 273 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional repressor involved in the inhibition of plant growth under abiotic stress conditions, Can repress the expression of various genes, including osmotic stress and abscisic acid-repressive genes and auxin-inducible genes, by binding to their promoter regions in a DNA sequence-specific manner, Acts as a negative regulator of abscisic acid (ABA) signaling during seed germination, Probably involved in jasmonate (JA) early signaling response, May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade, May act as a positive regulator of leaf senescence, Has been identified as a suppressor of the deficiency of yeast snf4 mutant to grow on non-fermentable carbon source


This is E3 ubiquitin-protein ligase SINAT4 protein, from Mouse-ear cress, contains 327 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:32786047), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:32786047), It probably triggers the ubiquitin-mediated degradation of different substrates (PubMed:32786047), Modulates directly the ubiquitination and proteasomal-dependent degradation of FREE1, a component of the ESCRT-I complex (PubMed:32786047, PubMed:32753431), Modulates directly the ubiquitination and proteasomal-dependent degradation of ELC/VPS23A, a component of the ESCRT-I complex (PubMed:32753431)

Belongs to the SINA (Seven in absentia) family


This is Origin of replication complex subunit 1B protein, from Mouse-ear cress, contains 813 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Essential protein required for ovules fertilization (PubMed:15634699, PubMed:19171893), Component of the origin recognition complex (ORC) that binds origins of replication, It has a role in both chromosomal replication and mating type transcriptional silencing, Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity), H3K4me3 effector that regulates positively the transcription of a subset of genes (PubMed:19171893)


This is VIN3-like protein 2 protein, from Mouse-ear cress, contains 714 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Maybe involved in both the vernalization and photoperiod pathways by regulating gene expression, Binds preferentially to dimethylated histone H3 'Lys-9' (H3K9me2), Promotes flowering in non-inductive photoperiods (e,g, short days) through the maintenance of the epigenetically repressed state of MAF5 via H3K9me2 and plant homeodomain / polycomb repressive complex 2 (PHD-PRC2)-dependent H3K27me3


This is Zinc-finger homeodomain protein 7 protein, from Mouse-ear cress, contains 249 amino acids, has 1 ZF-HD dimerization-type Zinc finger.

ZF-HD dimerization-type


This is Zinc finger protein WIP2 protein, from Mouse-ear cress, contains 383 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

C2H2-type 4; atypical

Transcriptional regulator required for normal differentiation of the ovary transmitting tract cells and pollen tube growth, In Arabidopsis, the transmitting tract facilitates the transport of pollen tubes to the ovules for fertilization (PubMed:17600712), May play a role in the regulation of AGL8/FUL, which is required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique (PubMed:23515580), Plays a role in replum development by the activation of the homeobox protein KNAT1 (PubMed:25039392)

Belongs to the WIP C2H2-type zinc-finger protein family


This is Protein FAR-RED IMPAIRED RESPONSE 1 protein, from Mouse-ear cress, contains 827 amino acids, has 1 SWIM-type Zinc finger.

SWIM-type

Transcription activator that recognizes and binds to the DNA consensus sequence 5'-CACGCGC-3', Activates the expression of FHY1 and FHL involved in light responses, Positive regulator of chlorophyll biosynthesis via the activation of HEMB1 gene expression


This is BTB/POZ and TAZ domain-containing protein 3 protein, from Mouse-ear cress, contains 364 amino acids, has 1 TAZ-type Zinc finger.

TAZ-type

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Essential for female and male gametophyte development


This is B-box zinc finger protein 22 protein, from Mouse-ear cress, contains 299 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Acts as positive regulator of seedling photomorphogenesis and light-regulated inhibition of hypocotyl elongation, independently and in concert with HY5 and BBX21 (PubMed:18540109, PubMed:18796637, PubMed:18182030, PubMed:21427283), Acts as a positive regulator of de-etiolation and influences chloroplast biogenesis and function through regulation of genes encoding chloroplast proteins (PubMed:18182030), Acts downstream of COP1 and plays an important role in early and long-term adjustment of the shade avoidance syndrome (SAS) responses in natural environments (PubMed:21070414), Regulates the expression of genes responsive to light hormone signals which may contribute to optimal seedling development (PubMed:21427283)


This is Peroxisome biogenesis factor 10 protein, from Mouse-ear cress, contains 381 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:12883010, PubMed:14576288, PubMed:17215364, PubMed:17478547, PubMed:20679226, PubMed:23336935, PubMed:25214533), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:23336935, PubMed:25214533), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is Putative GATA transcription factor 22 protein, from Mouse-ear cress, contains 352 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters (PubMed:22102866, PubMed:25077795), Involved in the modulation of chloroplast development, growth and division in a cytokinin-dependent manner (PubMed:22102866, PubMed:22811435), Repressor of the gibberellic acid (GA) signaling pathway that regulates flowering and modulates greening, in a SOC1-dependent manner (PubMed:20844019, PubMed:23739688, PubMed:25077795), Prevents the accumulation of SOC1 during flowering (PubMed:23739688), Promotes chlorophyll biosynthesis throughout the plant, by regulating chlorophyll biosynthetic genes (e,g, HEMA1 and GUN4) and chloroplast localized glutamate synthase (e,g, GLU1) (PubMed:18417639, PubMed:20844019, PubMed:21453984, PubMed:22102866, PubMed:23878229, PubMed:25077795), Involved in the regulation of sugar-sensing genes (e,g, HXK1, HXK2, STP13 and PLT6) (PubMed:18417639), Regulator of germination, senescence, elongation growth and flowering time (PubMed:20844019, PubMed:22102866, PubMed:23878229), Influences also leaf starch content (PubMed:22102866)

Belongs to the type IV zinc-finger family, Class B subfamily


This is Polycomb complex protein BMI-1 protein, from Cat, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A, In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2


This is Androgen receptor protein, from Dog, contains 907 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation, Transcription activation is also down-regulated by NR0B2, Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3


This is Gag polyprotein protein, from KoRV, contains 521 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome, Binds with high affinity to conserved elements within the packaging signal, located near the 5'-end of the genome, This binding is dependent on genome dimerization


This is COUP transcription factor 2 protein, from Bovine, contains 414 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro), Regulation of the apolipoprotein A-I gene transcription, Binds to DNA site A, May be required to establish ovary identity during early gonad development

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Estrogen receptor protein, from Horse, contains 594 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP, Can activate the transcriptional activity of TFF1, Also mediates membrane-initiated estrogen signaling involving various kinase cascades,Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity)


This is Transcription elongation factor SPT4 protein, from Fruit fly, contains 116 amino acids, has 1 C4-type Zinc finger.

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II, DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex, DSIF may also promote transcriptional elongation within coding regions, DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By similarity)


This is Histone acetyltransferase Tip60 homolog protein, from Caenorhabditis elegans, contains 458 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Probable catalytic subunit of the Tip60 chromatin-remodeling complex, May acetylate nucleosomal histone H4 and H2A (PubMed:15068795), Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates (PubMed:15068795, PubMed:20181741)


This is Kruppel-like factor 1 protein, from Caenorhabditis elegans, contains 497 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor which modulates genes involved in lipid metabolism and the phase I detoxification pathway, including cytochrome P450 oxidases (PubMed:18680432, PubMed:24805825, PubMed:31346165), Required for diet restriction- and mitochondrial dysfunction-mediated lifespan extension, perhaps acting in a ubiquitination-dependent manner (PubMed:24805825, PubMed:31346165), Involved in the response to oxidative stress (PubMed:31346165), Plays a role in cell death (PubMed:18680432)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Lysine-specific demethylase 4 protein, from Caenorhabditis elegans, contains 922 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type; degenerate Zinc finger.

C2HC pre-PHD-type

PHD-type; degenerate

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:16603238, PubMed:24685137), Demethylation of Lys residue generates formaldehyde and succinate, Involved in the negative regulation of lifespan in a germline-dependent fashion (PubMed:22212395)

Belongs to the JHDM3 histone demethylase family


This is 5'-3' exoribonuclease 2 homolog protein, from Caenorhabditis elegans, contains 975 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Possesses 5'->3' exoribonuclease activity (PubMed:19734881, PubMed:21397849), Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA (PubMed:19734881, PubMed:21397849, PubMed:26779609), Degradation role is enhanced when in complex with paxt-1 (PubMed:24462208, PubMed:26779609), Partially redundant to xrn-1 in miRNA guide strand degradation (PubMed:19734881, PubMed:21397849), Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA (PubMed:19734881, PubMed:21397849), Positively regulates molting of the pharyngeal cuticle (PubMed:16122351, PubMed:19734881)

Belongs to the 5'-3' exonuclease family, XRN2/RAT1 subfamily


This is Probable E3 ubiquitin-protein ligase plr-1 protein, from Caenorhabditis elegans, contains 487 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity), Acts on both canonical and non-canonical Wnt signaling pathway (By similarity), Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG (PubMed:24401370, PubMed:25448694), Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the Wnt signaling proteins cfz-2, mig-1 and mom-5 to endosomes which thereby reduces their cell surface expression and negatively regulates Wnt signaling (PubMed:24401370), May also regulate AVG polarity and axon guidance through Wnt-independent mechanisms involving unc-53/Nav2, unc-73/Trio and cytosolic protein vab-8 (PubMed:25448694)


This is Transcription factor grauzone protein, from Fruit fly, contains 570 amino acids, has 8 C2H2-type Zinc finger.

Transcription factor essential for the completion of meiosis in oocytes, Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries


This is Protein borderless protein, from Fruit fly, contains 719 amino acids, has 4 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

In the developing eye, has a role in axonal targeting of the R7 photoreceptor where it functions together with tutl, Probably mediates homotypic cell adhesion; the effect is inhibited by Lar

Belongs to the immunoglobulin superfamily


This is DNA (cytosine-5)-methyltransferase 3B protein, from Human, contains 853 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development, DNA methylation is coordinated with methylation of histones, May preferentially methylates nucleosomal DNA within the nucleosome core region, May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation, Seems to be involved in gene silencing (By similarity), In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9, Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs, Functions as a transcriptional corepressor by associating with ZHX1, Required for DUX4 silencing in somatic cells (PubMed:27153398)

Belongs to the class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family


This is RING-box protein 2 protein, from Human, contains 113 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089), CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity), Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate, Promotes the neddylation of CUL5 via its interaction with UBE2F, May play a role in protecting cells from apoptosis induced by redox agents


This is Myotilin protein, from Human, contains 498 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Component of a complex of multiple actin cross-linking proteins, Involved in the control of myofibril assembly and stability at the Z lines in muscle cells


This is Set1/Ash2 histone methyltransferase complex subunit ASH2 protein, from Human, contains 628 amino acids, has 1 PHD-type; atypical Zinc finger, has 1 C4-type Zinc finger.

PHD-type; atypical

Transcriptional regulator (PubMed:12670868), Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338), Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245), As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245), May play a role in hematopoiesis (PubMed:12670868), In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653)


This is E3 ubiquitin-protein ligase RNF14 protein, from Human, contains 474 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793), Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates ubiquitination of EEF1A1/eEF1A, leading to its degradation (PubMed:36638793), In addition to EEF1A1/eEF1A, RNF14 catalyzes ubiquitination of other translation factors on stalled ribosomes: mediates ubiquitination and degradation of ETF1/eRF1 and ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793), Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interation with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499), May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326)

Belongs to the RBR family, RNF14 subfamily


This is DNA polymerase kappa protein, from Human, contains 870 amino acids, has 2 UBZ4-type Zinc finger.

DNA polymerase specifically involved in DNA repair, Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls, Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts, Lacks 3'-5' proofreading exonuclease activity, Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity

Belongs to the DNA polymerase type-Y family


This is Protein DBF4 homolog A protein, from Human, contains 674 amino acids, has 1 DBF4-type Zinc finger.

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation, Required for progression of S phase, The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle


This is DNA-(apurinic or apyrimidinic site) endonuclease 2 protein, from Human, contains 518 amino acids, has 1 GRF-type Zinc finger.

GRF-type

Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656), Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598), Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450), Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656), Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450), In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153), Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598), Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity), Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity)

Belongs to the DNA repair enzymes AP/ExoA family


This is Zinc finger protein 69 protein, from Human, contains 566 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 13 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 212 protein, from Human, contains 495 amino acids, has 4 C2H2-type Zinc finger.


This is Zinc finger matrin-type protein 5 protein, from Human, contains 170 amino acids, has 1 C3H1-type Zinc finger.


This is Tripartite motif-containing protein 10 protein, from Human, contains 481 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells, May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity), In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity, Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647)


This is Mucosa-associated lymphoid tissue lymphoma translocation protein 1 protein, from Human, contains 824 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955), Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101), Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101), Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity), Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753), May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475)


This is Zinc finger protein 629 protein, from Human, contains 869 amino acids, has 19 C2H2-type Zinc finger.


This is Zinc finger and BTB domain-containing protein 47 protein, from Human, contains 747 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate


This is Ubiquitin thioesterase ZRANB1 protein, from Human, contains 708 amino acids, has 3 RanBP2-type Zinc finger.

Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577), Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465), Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465), Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724), Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987), Required in the stress fiber dynamics and cell migration (PubMed:21834987)


This is CMRF35-like molecule 8 protein, from Human, contains 299 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027), Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923)


This is Zinc finger CCCH domain-containing protein 7B protein, from Human, contains 977 amino acids, has 4 C3H1-type Zinc finger, has 1 C2H2-type Zinc finger.

May be a specific regulator of miRNA biogenesis, Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop


This is Transcription factor COE1 protein, from Human, contains 591 amino acids, has 1 C5-type Zinc finger.

(Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461), In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314)


This is E3 ubiquitin-protein ligase makorin-1 protein, from Human, contains 482 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, These substrates include FILIP1, p53/TP53, CDKN1A and TERT, Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions, Acts as a negative regulator of telomerase, Has negative and positive effects on RNA polymerase II-dependent transcription


This is FMR1-interacting protein NUFIP1 protein, from Human, contains 495 amino acids, has 1 C2H2-type Zinc finger.


This is SLAM family member 5 protein, from Human, contains 345 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity), Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process, Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway, May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647, PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation, In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity), In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234), In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity), Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592)


This is Zinc finger protein 639 protein, from Human, contains 485 amino acids, has 8 C2H2-type Zinc finger.

Binds DNA and may function as a transcriptional repressor


This is Zinc finger protein 230 protein, from Human, contains 474 amino acids, has 9 C2H2-type Zinc finger, has 1 C2H2-type 10; atypical Zinc finger.

C2H2-type 10; atypical


This is Krueppel-like factor 15 protein, from Human, contains 416 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator that binds to the GA element of the CLCNKA promoter, Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity), Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis, It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity), Involved in podocyte differentiation (By similarity), Inhibits MYOCD activity, Is a negative regulator of TP53 acetylation, Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is PHD finger protein 11 protein, from Human, contains 331 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type Zinc finger.

C2HC pre-PHD-type

PHD-type

Positive regulator of Th1-type cytokine gene expression


This is Butyrophilin-like protein 2 protein, from Human, contains 455 amino acids, has 3 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type

Negative regulator of T-cell proliferation

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Methyl-CpG-binding domain protein 1 protein, from Human, contains 605 amino acids, has 3 CXXC-type Zinc finger.

CXXC-type

CXXC-type

CXXC-type

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides, Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS), Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1, Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation, Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters


This is Rab5 GDP/GTP exchange factor protein, from Human, contains 491 amino acids, has 1 A20-type Zinc finger.

Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A, Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes, Stimulates nucleotide exchange on RAB5A, Can act as a ubiquitin ligase (By similarity)


This is Zinc finger MYM-type protein 5 protein, from Human, contains 669 amino acids, has 4 MYM-type Zinc finger.

MYM-type

MYM-type

MYM-type

MYM-type

Functions as a transcriptional regulator


This is Zinc finger protein 69 homolog B protein, from Human, contains 534 amino acids, has 9 C2H2-type Zinc finger.

May be involved in transcriptional regulation, Essential for Golgi structural integrity (PubMed:29851555)


This is Probable E3 ubiquitin-protein ligase MID2 protein, from Human, contains 735 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; degenerate

B box-type

E3 ubiquitin ligase that plays a role in microtubule stabilization, Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons, This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954)


This is Probable ATP-dependent RNA helicase DDX41 protein, from Human, contains 622 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Probable ATP-dependent RNA helicase, Is required during post-transcriptional gene expression, May be involved in pre-mRNA splicing

Belongs to the DEAD box helicase family, DDX41 subfamily


This is DNA (cytosine-5)-methyltransferase 3-like protein, from Human, contains 386 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity), Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327), Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327), Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327), Plays a key role in embryonic stem cells and germ cells (By similarity), In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity), In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity), Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity), While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity), Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity), Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity)


This is Zinc finger protein 180 protein, from Human, contains 692 amino acids, has 12 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein 580 protein, from Human, contains 172 amino acids, has 3 C2H2-type Zinc finger.

Involved in the regulation of endothelial cell proliferation and migration, Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation, May be involved in transcriptional regulation


This is Inhibitor of growth protein 1 protein, from Human, contains 422 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation, Implicated as a tumor suppressor gene


This is Paired immunoglobulin-like type 2 receptor alpha protein, from Human, contains 303 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

(Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1


This is PR domain zinc finger protein 4 protein, from Human, contains 801 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 4 C2H2-type Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 1; atypical

C2H2-type 6; atypical

May function as a transcription factor involved in cell differentiation

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Zinc finger protein Helios protein, from Human, contains 526 amino acids, has 6 C2H2-type Zinc finger.

Associates with Ikaros at centromeric heterochromatin

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is F-box only protein 5 protein, from Human, contains 447 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029), During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029), During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408), Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408), As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:23708605, PubMed:23708001, PubMed:16921029), Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940), During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex, Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity), Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity), Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565)


This is Zinc finger protein Aiolos protein, from Human, contains 509 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 4; atypical

C2H2-type 6; atypical

Transcription factor that plays an important role in the regulation of lymphocyte differentiation, Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state, Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner


This is E3 ubiquitin-protein ligase AMFR protein, from Human, contains 643 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676), Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410), The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767), In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569), The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569), In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676), Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353), Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408), Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303), Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303), Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327), In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040), Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296)


This is Guanine nucleotide exchange factor VAV3 protein, from Human, contains 847 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1, Binds physically to the nucleotide-free states of those GTPases, Plays an important role in angiogenesis, Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity), May be important for integrin-mediated signaling, at least in some cell types, In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function, This signaling pathway involves RAC1, but not RHO, activation, Necessary for proper wound healing, In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils, Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion, Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity)


This is Zinc fingers and homeoboxes protein 1 protein, from Human, contains 873 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor, Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA, May link molecule between DNMT3B and other co-repressor proteins


This is Zinc finger protein 346 protein, from Human, contains 294 amino acids, has 4 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

Matrin-type

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053), May bind to specific miRNA hairpins (PubMed:28431233)


This is Paraneoplastic antigen Ma3 protein, from Human, contains 463 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Zinc finger protein 777 protein, from Human, contains 831 amino acids, has 9 C2H2-type Zinc finger.

May be involved in transcriptional repression (PubMed:31856708), Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148)


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 2 protein, from Human, contains 789 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Promotes neurite outgrowth in hippocampal neurons, Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A, May play a role in redistributing DLG4 to the cell periphery (By similarity)


This is Zinc finger protein 490 protein, from Human, contains 529 amino acids, has 13 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase ZNRF3 protein, from Human, contains 936 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6, Acts on both canonical and non-canonical Wnt signaling pathway, Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959), Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)


This is Cip1-interacting zinc finger protein protein, from Human, contains 898 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

May regulate the subcellular localization of CIP/WAF1


This is E3 ubiquitin-protein ligase CBL-C protein, from Human, contains 474 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome, Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3, Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR, Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation, Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival


This is RNA-binding protein NOB1 protein, from Human, contains 412 amino acids, has 1 NOB1 Zinc finger.

May play a role in mRNA degradation (Probable), Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity)


This is RING finger protein 112 protein, from Human, contains 631 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development, During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:28684796), Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage, Exhibits GTPase and E3 ubiquitin-protein ligase activities, Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily


This is A-kinase anchor protein 8-like protein, from Human, contains 646 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

(Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity


This is HERV-H LTR-associating protein 2 protein, from Human, contains 414 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Ig-like V-type

Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation, Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade


This is Zinc finger protein PLAGL1 protein, from Human, contains 463 amino acids, has 7 C2H2-type Zinc finger.

Acts as a transcriptional activator (PubMed:9722527), Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide


This is Intercellular adhesion molecule 5 protein, from Human, contains 924 amino acids, has 9 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

Belongs to the immunoglobulin superfamily, ICAM family


This is Rab effector Noc2 protein, from Human, contains 315 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity), Acts as a potential RAB3B effector protein in epithelial cells


This is Inhibitor of growth protein 4 protein, from Human, contains 249 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653), Through chromatin acetylation it may function in DNA replication (PubMed:16387653), May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276), Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197), May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197), Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452), Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)


This is Zinc finger protein 232 protein, from Human, contains 417 amino acids, has 5 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein PLAGL2 protein, from Human, contains 496 amino acids, has 6 C2H2-type Zinc finger.

Shows weak transcriptional activatory activity


This is Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 protein, from Human, contains 857 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ARF1 and, to a lesser extent, ARF5, Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system

Belongs to the centaurin gamma-like family