This is Potential E3 ubiquitin-protein ligase ariadne-2 protein, from Caenorhabditis elegans, contains 482 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBC-2/UBE2L3, and then transfers it to substrates

Belongs to the RBR family, Ariadne subfamily


This is Zinc finger protein pat-9 protein, from Caenorhabditis elegans, contains 470 amino acids, has 3 C2H2-type Zinc finger.

Probable transcription factor; required for proper organization of muscle myofilaments and for their recruitment to the M line

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Protein tumorous imaginal discs, mitochondrial protein, from Fruit fly, contains 529 amino acids, has 1 CR-type Zinc finger.

CR-type

May act as a tumor suppressor in larval imaginal disks


This is Zinc finger HIT domain-containing protein 1 protein, from Bovine, contains 154 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A,Z into the genome to regulate gene expression (By similarity), Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (By similarity), Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone H2AZ1 to chromatin and induces muscle-specific gene expression (By similarity), Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (By similarity), Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (By similarity), Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (By similarity), Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (By similarity), Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (By similarity), During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (By similarity), In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (By similarity), Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (By similarity), Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (By similarity), Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (By similarity), Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (By similarity), Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (By similarity)


This is AT-rich binding protein protein, from Flesh fly, contains 354 amino acids, has 3 C2H2-type Zinc finger.

May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions, Binds to AT rich DNA


This is Vitamin D3 receptor protein, from Bovine, contains 426 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells, Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR, The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity), Plays a central role in calcium homeostasis (By similarity), Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Brevican core protein protein, from Bovine, contains 912 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a role in the terminally differentiating and the adult nervous system during postnatal development, Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

Secreted, extracellular space, extracellular matrix

Belongs to the aggrecan/versican proteoglycan family


This is T-cell-specific surface glycoprotein CD28 protein, from Bovine, contains 219 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival, Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation


This is T-cell surface glycoprotein CD3 gamma chain protein, from Bovine, contains 173 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways, In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface, Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G


This is Low affinity immunoglobulin gamma Fc region receptor II protein, from Bovine, contains 296 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Binds to the Fc region of immunoglobulins gamma, Low affinity receptor


This is Advanced glycosylation end product-specific receptor protein, from Bovine, contains 416 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans, Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes, These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses, Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B, Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (By similarity), Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity), Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons, ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space, Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability, Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome, Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (By similarity)


This is Protein DBF4 homolog B protein, from African clawed frog, contains 784 amino acids, has 1 DBF4-type Zinc finger.

Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation, Specifically required during the initiation of DNA replication in egg and during early embryonic development, The complex cdc7-dbf4b phosphorylates mcm2 and mcm4 subunits and is required for cdc45 loading


This is Thyroid hormone receptor alpha protein, from Sheep, contains 410 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine


This is Thyroid hormone receptor beta protein, from Sheep, contains 411 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Intercellular adhesion molecule 5 protein, from Rabbit, contains 912 amino acids, has 9 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

Belongs to the immunoglobulin superfamily, ICAM family


This is Basigin protein, from Rabbit, contains 270 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like C2-type

Ig-like V-type

Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity), Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (By similarity), Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity), Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like protein, from Western clawed frog, contains 639 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs), Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs, Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation

Belongs to the Dus family, Dus3 subfamily


This is Maternal DNA replication licensing factor mcm6 protein, from Western clawed frog, contains 821 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development


This is Ubiquitin carboxyl-terminal hydrolase 33 protein, from Western clawed frog, contains 892 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling, Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate, Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling, Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2), Deubiquitinates dio2, thereby regulating thyroid hormone regulation, Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)

Belongs to the peptidase C19 family, USP20/USP33 subfamily


This is TNF receptor-associated factor 6 protein, from Western clawed frog, contains 558 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation

Belongs to the TNF receptor-associated factor family, A subfamily


This is E3 ubiquitin-protein ligase SH3RF1 protein, from Western clawed frog, contains 861 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity, In the absence of an external substrate, it can catalyze self-ubiquitination, Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway


This is E3 ubiquitin-protein ligase MARCHF2 protein, from Western clawed frog, contains 246 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is F-box only protein 5 protein, from Western clawed frog, contains 391 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC), Binds to the APC activators cdc20 to prevent APC activation, Can also bind directly to the APC to inhibit substrate-binding, Required to arrest unfertilized eggs at metaphase of meiosis II, by preventing their release from metaphase of meiosis II, through inhibition of APC-dependent cyclin B destruction leading to stabilization of cyclin B-cdk1 complex activity


This is E3 ubiquitin-protein ligase MARCHF8 protein, from Western clawed frog, contains 264 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that mediates ubiquitination of cd86 and MHC class II proteins, such as hla-dr alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies


This is Aggrecan core protein protein, from Pig, contains 537 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues, A major function of this protein is to resist compression in cartilage, It binds avidly to hyaluronic acid via an N-terminal globular region, May play a regulatory role in the matrix assembly of the cartilage


This is T-cell surface glycoprotein CD4 protein, from Common squirrel monkey, contains 457 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is Interleukin-1 receptor type 2 protein, from Green monkey, contains 393 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Non-signaling receptor for IL1A, IL1B and IL1RN, Reduces IL1B activities, Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1, Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B, IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN, The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity)

Belongs to the interleukin-1 receptor family


This is DNA replication licensing factor Mcm6 protein, from Fruit fly, contains 815 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity


This is E3 ubiquitin-protein ligase TRIM9 protein, from Bovine, contains 710 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation, May play a role in regulation of neuronal functions, May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation


This is E3 ubiquitin-protein ligase RNF128 protein, from Bovine, contains 431 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation, Functions as an inhibitor of cytokine gene transcription, Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production, Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse, Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals


This is DNA topoisomerase 1 protein, from Staphylococcus aureus (strain USA300), contains 689 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is DNA topoisomerase 1 protein, from Staphylococcus aureus (strain NCTC 8325 / PS 47), contains 689 amino acids, has 3 C4-type Zinc finger.


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Soil fungus, contains 713 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)


This is Protein Mdm4 protein, from Bovine, contains 491 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Inhibits degradation of MDM2, Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity)


This is DnaJ homolog subfamily A member 2 protein, from Bovine, contains 412 amino acids, has 1 CR-type Zinc finger.

CR-type

Co-chaperone of Hsc70, Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha protein, from Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3), contains 618 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity)

In the C-terminal section; belongs to the AccA family


This is Sodium channel subunit beta-3 protein, from Bovine, contains 215 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Modulates channel gating kinetics, Causes unique persistent sodium currents, Inactivates the sodium channel opening more slowly than the subunit beta-1, Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity)

Belongs to the sodium channel auxiliary subunit SCN3B (TC 8,A,17) family


This is Four and a half LIM domains protein 2 protein, from Bovine, contains 279 amino acids, has 1 C4-type Zinc finger.

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation, Negatively regulates the transcriptional repressor E4F1 and may function in cell growth, Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation, Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (By similarity)


This is Trem-like transcript 2 protein protein, from Mouse, contains 329 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor that may play a role in the innate and adaptive immune response, Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity)


This is Zinc finger protein 674 protein, from Human, contains 581 amino acids, has 11 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Tomato, contains 490 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity), Is up-regulated upon chromoplast differentiation, presumably for fatty acid biosynthesis


This is Zinc finger protein STAR3 protein, from Rice, contains 465 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

C2H2-type 4; atypical

Transcriptional activator that regulates the expression of genes involved in aluminum (Al) tolerance, Binds to the promoter of STAR1 and regulates transcript expression of STAR1 STAR2 and ART1 required for Al tolerance


This is E3 ubiquitin-protein ligase TRIM17 protein, from Bovine, contains 475 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation, Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation, Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies, Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity), Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death, In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities, Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity), Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity)


This is Arf-GAP domain and FG repeat-containing protein 1 protein, from Bovine, contains 562 amino acids, has 1 C4-type Zinc finger.

Required for vesicle docking or fusion during acrosome biogenesis, May play a role in RNA trafficking or localization (By similarity)


This is Peroxynitrite isomerase THAP4 protein, from Bovine, contains 584 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate, Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively), Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region

In the C-terminal section; belongs to the nitrobindin family


This is Matrix metalloproteinase-23 protein, from Bovine, contains 393 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease, May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yellow koji mold, contains 730 amino acids, has 2 C3H1-type Zinc finger.


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Potato, contains 490 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Zinc finger protein 703-B protein, from African clawed frog, contains 531 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters, Regulates cell adhesion, migration and proliferation (By similarity), Involved in specification of the lateral neural plate border (NPB) (PubMed:28716930), May be required for segmental gene expression during hindbrain development (By similarity)


This is Fez family zinc finger protein 2 protein, from Bovine, contains 458 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor, Binds to 5'GCAG-3' core sequence, Required for the specification of corticospinal motor neurons and other subcerebral projection neurons, May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation, Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity), May be responsible for mastitis resistance and innate immunity


This is Cell surface glycoprotein CD200 receptor 1-A protein, from Chicken, contains 300 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type


This is DNA topoisomerase 1 protein, from Staphylococcus aureus (strain bovine RF122 / ET3-1), contains 689 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is Mamu class II histocompatibility antigen, DR alpha chain protein, from Rhesus macaque, contains 254 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Hornwort, contains 313 amino acids, has 1 C4-type Zinc finger.


This is E3 ubiquitin-protein ligase RNF138 protein, from Bovine, contains 245 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger, has 2 C2H2-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination, Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination, Two different, non-exclusive, mechanisms have been proposed, According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination, According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP, Together with NLK, involved in the ubiquitination and degradation of TCF/LEF, Also exhibits auto-ubiquitination activity in combination with UBE2K, May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway


This is Zinc finger protein 699 protein, from Human, contains 642 amino acids, has 14 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 9; degenerate


This is E3 ubiquitin-protein ligase arih1 protein, from African clawed frog, contains 529 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3, Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets, The initial ubiquitin is then elongated, E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes


This is Ubiquitin thioesterase OTU1 protein, from Rat, contains 343 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore, Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel, Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains, Also able to hydrolyze 'Lys-11'-linked ubiquitin chains, Cleaves both polyubiquitin and di-ubiquitin, May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes, May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Tobacco, contains 495 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein dnaJ 1, mitochondrial protein, from Mouse-ear cress, contains 408 amino acids, has 1 CR-type Zinc finger.

CR-type

Plays a continuous role in plant development probably in the structural organization of compartments

Belongs to the DnaJ family, B/II subfamily


This is Diacylglycerol kinase 1 protein, from Mouse-ear cress, contains 728 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule, PA is required for plant development and responses to abiotic stress and pathogen attack, May be involved in the accumulation of PA during cold stress (By similarity)

Belongs to the eukaryotic diacylglycerol kinase family


This is Zinc finger protein 2 protein, from Mouse-ear cress, contains 150 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor involved in the regulation of floral organ abscission, Participates in processes that directly or indirectly influence shedding of floral organs


This is Zinc finger protein 3 protein, from Mouse-ear cress, contains 235 amino acids, has 1 C2H2-type Zinc finger.

Acts as negative regulator of abscisic acid (ABA) signaling during germination and early seedling development, Involved in the regulation of vegetative development and fertility, Modulates red light signaling in seedling photomorphogenesis


This is Zinc finger protein 4 protein, from Mouse-ear cress, contains 260 amino acids, has 1 C2H2-type Zinc finger.

Acts as negative regulator of abscisic acid (ABA) signaling during germination and early seedling development


This is Zinc finger protein 7 protein, from Mouse-ear cress, contains 209 amino acids, has 1 C2H2-type Zinc finger.


This is Zinc finger and BTB domain-containing protein 24 protein, from Rat, contains 705 amino acids, has 8 C2H2-type Zinc finger.

May be involved in BMP2-induced transcription


This is Pre-mRNA-splicing factor RBM22 protein, from Bovine, contains 420 amino acids, has 1 C3H1-type Zinc finger.

Required for pre-mRNA splicing as component of the activated spliceosome, Involved in the first step of pre-mRNA splicing, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle, Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses


This is Zinc finger protein 746 protein, from Bovine, contains 630 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 2 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 1; atypical

C2H2-type 4; degenerate

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death


This is Formamidopyrimidine-DNA glycosylase protein, from Xanthomonas campestris pv. vesicatoria (strain 85-10), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Wood tobacco, contains 495 amino acids, has 1 C4-type Zinc finger.


This is E3 ubiquitin-protein ligase MARCHF5 protein, from Mouse, contains 278 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission, May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control, Promotes ubiquitination of FIS1, DNM1L and MFN1


This is Carcinoembryonic antigen-related cell adhesion molecule 21 protein, from Human, contains 293 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Belongs to the immunoglobulin superfamily, CEA family


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like protein, from Rat, contains 640 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs), Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs, Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation


This is mRNA export factor ICP27 homolog protein, from HHV-4, contains 479 amino acids, has 1 CHC2-type Zinc finger.

Promotes the nuclear export of a subset of early and late viral mRNAs by interacting with mRNAs and cellular export proteins, Additionally may prevent the establishment of cellular antiviral state, by acting as an alternative splicing factor for cellular RNAs such as STAT1, resulting in a STAT1 mRNA incapable of producing the STAT1alpha isoform

Belongs to the HHV-1 ICP27 protein family


This is Large T antigen protein, from SV-12, contains 699 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription


This is B-lymphocyte antigen CD19 protein, from White-tufted-ear marmoset, contains 558 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes, Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity), Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores, Is not required for early steps during B cell differentiation in the blood marrow, Required for normal differentiation of B-1 cells, Required for normal B cell differentiation and proliferation in response to antigen challenges, Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (By similarity)


This is Endonuclease 8-like 3 protein, from Bovine, contains 606 amino acids, has 1 FPG-type Zinc finger, has 1 RanBP2-type Zinc finger, has 2 GRF-type Zinc finger.

FPG-type

GRF-type

GRF-type

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (By similarity), Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity), In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA, No activity on 8-oxoG detected, Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity, In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (By similarity)


This is Lethal(3)malignant brain tumor-like protein 2 protein, from Rat, contains 703 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Putative Polycomb group (PcG) protein, PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility, Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis, Binds to monomethylated and dimethylated 'Lys-20' on histone H4, Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity)


This is TNF receptor-associated factor 6-A protein, from African clawed frog, contains 556 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation


This is E3 ubiquitin-protein ligase RNF183 protein, from Bovine, contains 188 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1, May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling


This is Zinc finger protein interacting with ribonucleoprotein K protein, from Human, contains 487 amino acids, has 9 C2H2-type Zinc finger.


This is Transcription factor GATA-5 protein, from Bovine, contains 403 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcription factor required during cardiovascular development, Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity, Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity)


This is Inhibitor of growth protein 4 protein, from Bovine, contains 248 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4, Through chromatin acetylation it may function in DNA replication, May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation, Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA, May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC, Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity), Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity)


This is CCHC-type zinc finger nucleic acid binding protein protein, from Bovine, contains 170 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity), Has a role as transactivator of the Myc promoter (By similarity), Binds single-stranded RNA in a sequence-specific manner (By similarity), Binds G-rich elements in target mRNA coding sequences (By similarity), Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity)


This is Serine/arginine-rich splicing factor 7 protein, from Bovine, contains 235 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for pre-mRNA splicing, Represses the splicing of MAPT/Tau exon 10, May function as export adapter involved in mRNA nuclear export such as of histone H2A, Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity, RNA-binding is semi-sequence specific (By similarity)

Belongs to the splicing factor SR family


This is Splicing factor U2AF 26 kDa subunit protein, from Bovine, contains 220 amino acids, has 2 C3H1-type Zinc finger.

RNA-binding protein that function as a pre-mRNA splicing factor, Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection, Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts, Also participates in the regulation of alternative pre-mRNA splicing, Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1, Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity), Shows a preference for AGC or AGA (By similarity)


This is E3 ubiquitin-protein ligase RNF146-B protein, from Bovine, contains 347 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex, Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2, Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity)


This is Zinc finger-containing ubiquitin peptidase 1 protein, from Mouse, contains 577 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains, Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains, Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage, Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress

Belongs to the peptidase C78 family, ZUFSP subfamily


This is Pleckstrin homology domain-containing family F member 1 protein, from Mouse, contains 279 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May induce apoptosis through the lysosomal-mitochondrial pathway, Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm, Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity)


This is Myelin protein zero-like protein 1 protein, from Mouse, contains 270 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor, which is involved in signal transduction processes, Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2, Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases, Isoform 2 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA, Isoform 1, but not isoform 2, may be involved in regulation of integrin-mediated cell motility (By similarity)


This is U4/U6.U5 tri-snRNP-associated protein 2 protein, from Mouse, contains 564 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome, Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint, Does not have ubiquitin-specific peptidase activity


This is Transcription factor YY2 protein, from Mouse, contains 378 amino acids, has 4 C2H2-type Zinc finger.

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes, May antagonize YY1 and function in development and differentiation

Belongs to the YY transcription factor family


This is RUN and FYVE domain-containing protein 4 protein, from Mouse, contains 563 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Positively regulates macroautophagy in primary dendritic cells, Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes, Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger


This is E3 ubiquitin-protein ligase MARCHF9 protein, from Mouse, contains 348 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is T-cell surface protein tactile protein, from Mouse, contains 602 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response, Promotes NK cell-target adhesion by interacting with PVR present on target cells, May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity)


This is Zinc finger protein 692 protein, from Mouse, contains 531 amino acids, has 5 C2H2-type Zinc finger.

May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Transcription factor IIIB 50 kDa subunit protein, from Mouse, contains 420 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase III transcription, Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites, Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress, Down-regulates expression of target genes in response to oxidative stress, Overexpression protects cells against apoptosis in response to oxidative stress


This is Box C/D snoRNA protein 1 protein, from Mouse, contains 460 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis


This is Carcinoembryonic antigen-related cell adhesion molecule 5 protein, from Mouse, contains 947 amino acids, has 7 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression, Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6, Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells


This is Fanconi anemia core complex-associated protein 20 protein, from Mouse, contains 186 amino acids, has 1 UBZ2-type Zinc finger.

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair, Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex, Promotes translesion synthesis via interaction with REV1 (By similarity)


This is Retrotransposon Gag-like protein 4 protein, from Mouse, contains 304 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in cognitive function in the brain, possibly via the noradrenergic system


This is E3 ubiquitin ligase TRIM40 protein, from Mouse, contains 246 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response, Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation, Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation


This is RING finger protein 207 protein, from Mouse, contains 635 amino acids, has 1 RING-type Zinc finger, has 1 B box-type; atypical Zinc finger.

RING-type

B box-type; atypical

Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner


This is Myelin protein zero-like protein 3 protein, from Mouse, contains 237 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Mineralocorticoid receptor protein, from Ma's night monkey, contains 984 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol, Binds to mineralocorticoid response elements (MRE) and transactivates target genes, The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity)

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Pre-mRNA-splicing factor SLU7 protein, from Bovine, contains 586 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for pre-mRNA splicing as component of the spliceosome, Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron, Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region, May be involved in the activation of proximal AG, Probably also involved in alternative splicing regulation


This is E3 ubiquitin-protein ligase MARCHF5 protein, from Bovine, contains 278 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission, May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control, Promotes ubiquitination of FIS1, DNM1L and MFN1


This is Anaphase-promoting complex subunit 11 protein, from Bovine, contains 84 amino acids, has 1 RING-type Zinc finger.

RING-type

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity)


This is Zinc finger protein 260 protein, from Human, contains 412 amino acids, has 13 C2H2-type Zinc finger.

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling, Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA, Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity)


This is Zinc finger protein 568 protein, from Human, contains 644 amino acids, has 15 C2H2-type Zinc finger.

Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction, Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers, Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta, May enhance proliferation or maintenance of neural stem cells


This is PHD finger protein Alfin1 protein, from Alfalfa, contains 257 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes (By similarity), Transcriptional regulator that binds specifically to DNA sequences 5'-GNGGTG-3' or 5'-GTGGNG-3', including promoter elements of the salt-inducible PRP2 gene, Plays a role in salinity tolerance


This is Dof zinc finger protein DOF3.7 protein, from Mouse-ear cress, contains 296 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor specifically involved in the maternal control of seed germination, Regulates transcription by binding to a 5'-AA[AG]G-3' consensus core sequence, May ensure the inactivity of a component that would be activated to trigger germination as a consequence of red light perception


This is Protein lin-28 homolog A protein, from Chicken, contains 202 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism, Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity), 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis, Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization, Suppressor of microRNA (miRNA) biogenesis, including that of let-7, Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase, This results in the terminal uridylation of target pre-miRNAs, Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity), Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins, Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation, Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity)


This is Tripartite motif-containing protein 60 protein, from Human, contains 471 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 SUMO-protein ligase that mediates SUMOylation of TAB2 leading to inhibition of NF-kappa-B and MAPK pathways by suppressing the TRAF6/TAB2/TAK1 complex


This is LON peptidase N-terminal domain and RING finger protein 3 protein, from Human, contains 759 amino acids, has 2 RING-type Zinc finger.

RING-type

RING-type


This is Inhibitor of growth protein 3 protein, from Rat, contains 421 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair, NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage, Component of a SWR1-like complex that specifically mediates the removal of histone H2A,Z/H2AZ1 from the nucleosome (By similarity)


This is Non-structural maintenance of chromosomes element 1 homolog protein, from Rat, contains 266 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate, Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex, Involved in maintenance of genome integrity, DNA damage response and DNA repair, NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair


This is DNA topoisomerase 1 protein, from Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41), contains 688 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is Antigen-presenting glycoprotein CD1d protein, from Chimpanzee, contains 335 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells


This is Putative E3 ubiquitin-protein ligase XBAT35 protein, from Mouse-ear cress, contains 462 amino acids, has 1 RING-type Zinc finger.

RING-type

No E3 ubiquitin-protein ligase activity observed when associated with the E2 enzyme UBC8 in vitro


This is Fibroblast growth factor receptor protein, from Transparent sea squirt, contains 747 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for basic fibroblast growth factor

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Alpha-aminoadipate/glutamate carrier protein LysW protein, from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770), contains 56 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

Carrier protein that bears the covalently bound substrates for arginine and lysine biosynthesis; bound L-glutamate is sequentially converted to L-ornithine, while bound alpha-aminoadipate (AAA) is sequentially converted to L-lysine


This is Probable ATP-dependent RNA helicase vasa-like protein, from Whiteleg shrimp, contains 703 amino acids, has 3 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

Involved in translational control mechanisms operating in early stages of oogenesis, Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts, Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation

Belongs to the DEAD box helicase family, DDX4/VASA subfamily


This is Mineralocorticoid receptor protein, from Bolivian squirrel monkey, contains 982 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol, Binds to mineralocorticoid response elements (MRE) and transactivates target genes, The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity)


This is AN1-type zinc finger protein 2B protein, from Rat, contains 257 amino acids, has 2 AN1-type Zinc finger.

Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum, It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum, It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed, May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation, By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway


This is Transcription elongation factor A protein 1 protein, from Rat, contains 301 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity)


This is E3 ubiquitin-protein ligase ZNRF3 protein, from African clawed frog, contains 784 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (PubMed:22575959), Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)


This is Speckle targeted PIP5K1A-regulated poly(A) polymerase protein, from Zebrafish, contains 797 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs, In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs, In addition to adenylyltransferase activity, also has uridylyltransferase activity, However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase

Belongs to the DNA polymerase type-B-like family


This is DNA topoisomerase 1 protein, from Staphylococcus haemolyticus (strain JCSC1435), contains 689 amino acids, has 3 C4-type Zinc finger.


This is Semaphorin-3G protein, from Mouse, contains 780 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Has chemorepulsive activities for sympathetic axons, Ligand of NRP2


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Corn smut fungus, contains 867 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)

Belongs to the Dus family, Dus3 subfamily


This is Vacuolar protein sorting-associated protein 27 protein, from Corn smut fungus, contains 916 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane


This is Sodium channel subunit beta-1 protein, from Dog, contains 218 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle, Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation, Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A

Belongs to the sodium channel auxiliary subunit SCN1B (TC 8,A,17) family


This is Zinc finger-containing ubiquitin peptidase 1 protein, from Crab-eating macaque, contains 578 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains, Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains, Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage, Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress


This is Pre-mRNA-splicing factor RBM22 protein, from Crab-eating macaque, contains 420 amino acids, has 1 C3H1-type Zinc finger.

Required for pre-mRNA splicing as component of the activated spliceosome, Involved in the first step of pre-mRNA splicing, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle, Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses


This is E3 ubiquitin-protein ligase ZNRF4 protein, from Crab-eating macaque, contains 429 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2, Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (By similarity), Could have a role in spermatogenesis (By similarity)


This is Calcium-binding and coiled-coil domain-containing protein 2 protein, from Crab-eating macaque, contains 398 amino acids, has 1 UBZ1-type Zinc finger.

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity), Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity), Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity), Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity), May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity)


This is E3 ubiquitin-protein transferase MAEA protein, from Crab-eating macaque, contains 396 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, MAEA is required for normal cell proliferation, The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity), Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity), Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity), Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis, Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity), May contribute to nuclear architecture and cells division events (By similarity)


This is Protein Tax-3 protein, from HTLV-3, contains 350 amino acids, has 1  Zinc finger.

Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways, Binds to two 21 bp repeat elements located within the LTRs, referred to as Tax-responsive element (TRE), Binding to TRE requires the interaction with CREB1 and CREBBP, Activation of NF-kappa-B leads to up-regulation of the expression of gene promoters containing NFkB motifs like IL8 or BCL2L1, Inhibits the action of p53/TP53 and MYCB, All these functions could lead to the possible occurrence of lymphoproliferative disorders, Required for viral replication

Belongs to the deltaretrovirus Tax protein family


This is E3 ubiquitin-protein ligase RNF114 protein, from Bovine, contains 230 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates, In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity, Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3, May promote the ubiquitination of TRAF6 as well, Acts also as a negative regulator of T-cell activation, Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation, Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C, This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence, May play a role in spermatogenesis


This is DNA topoisomerase 1 protein, from Rickettsia azadi, contains 776 amino acids, has 1 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is Pre-mRNA-splicing factor RBM22 protein, from Rat, contains 420 amino acids, has 1 C3H1-type Zinc finger.


This is F-box only protein 5-B protein, from African clawed frog, contains 384 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC), Binds to the APC activators cdc20 to prevent APC activation, Can also bind directly to the APC to inhibit substrate-binding, Required to arrest unfertilized eggs at metaphase of meiosis II, by preventing their release from metaphase of meiosis II, through inhibition of APC-dependent cyclin B destruction leading to stabilization of cyclin B-cdk1 complex activity


This is E3 ubiquitin-protein ligase Hakai protein, from African clawed frog, contains 496 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 C2H2-type Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing


This is Transcription factor IIIB 50 kDa subunit protein, from Rat, contains 416 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase III transcription, Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites, Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress, Down-regulates expression of target genes in response to oxidative stress, Overexpression protects cells against apoptosis in response to oxidative stress


This is Neurotrophin receptor-interacting factor 1 protein, from Rat, contains 822 amino acids, has 5 C2H2-type Zinc finger.

Transcription regulator which may participate in NGFR/p75(NTR)-mediated apoptosis, Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (By similarity)


This is Transcription factor E4F1 protein, from Zebrafish, contains 719 amino acids, has 7 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 3; degenerate

C2H2-type 9; degenerate

May function as a transcriptional repressor, May also function as a ubiquitin ligase, Functions in cell survival and proliferation through control of the cell cycle


This is Nuclear receptor subfamily 6 group A member 1-B protein, from Zebrafish, contains 455 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Probable orphan nuclear receptor, Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity)

Belongs to the nuclear hormone receptor family, NR6 subfamily


This is HEPACAM family member 2 protein, from Mouse, contains 463 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Required during prometaphase for centrosome maturation, Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (By similarity)


This is Forkhead box protein P2 protein, from African clawed frog, contains 706 amino acids, has 1 C2H2-type Zinc finger.


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Neosartorya fumigata, contains 726 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)


This is GATA-type transcription factor sreA protein, from Neosartorya fumigata, contains 546 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence element 5'-ATCWGATAA-3' of target promoters (PubMed:18721228), Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity) (PubMed:18721228), SreA targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis (PubMed:18721228)


This is Transmembrane E3 ubiquitin-protein ligase FLY2 protein, from Mouse-ear cress, contains 559 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that may be involved in xylem development


This is V-set domain-containing T-cell activation inhibitor 1 protein, from Rat, contains 282 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity, When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity, Involved in promoting epithelial cell transformation (By similarity)

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Zinc finger and BTB domain-containing protein 45 protein, from Mouse, contains 520 amino acids, has 4 C2H2-type Zinc finger.

May be involved in transcriptional regulation (Probable), In the central nervous system, may play a role in glial cell differentiation (PubMed:21131782)


This is Zinc finger protein 394 protein, from Human, contains 561 amino acids, has 7 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Arrestin domain-containing protein A protein, from Social amoeba, contains 580 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like protein, from Social amoeba, contains 671 amino acids, has 2 C3H1-type Zinc finger.


This is DnaJ homolog subfamily A member 1 homolog protein, from Social amoeba, contains 459 amino acids, has 1 CR-type Zinc finger.

CR-type

Co-chaperone for Hsp70 family members, Plays a role in protein transport into mitochondria and in the regulation of apoptosis via its role as co-chaperone (By similarity)


This is Inhibitor of growth protein 1 homolog protein, from Social amoeba, contains 324 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Involved in regulation of the growth and differentiation transition (GDT) process, probably by regulating gene expression via histone modification


This is Peroxisome biogenesis factor 10 protein, from Social amoeba, contains 374 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is Transcription factor stalky protein, from Social amoeba, contains 872 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Probable transcription factor, Seems to act on the expression of the genes culC, culD, rnpA and sigB


This is Ubiquitin thioesterase OTU1 protein, from Zebrafish, contains 301 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore, Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel, Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains, Also able to hydrolyze 'Lys-11'-linked ubiquitin chains, Cleaves both polyubiquitin and di-ubiquitin


This is Protein odd-skipped-related 2 protein, from Zebrafish, contains 238 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional repressor (By similarity), Required for pronephric kidney development

Belongs to the Odd C2H2-type zinc-finger protein family


This is Zinc finger protein 354C protein, from Mouse, contains 560 amino acids, has 11 C2H2-type Zinc finger.

May function as a transcription repressor, Binds to 5'-CCACA-3' core sequence, Suppresses osteogenic effects of RUNX2, May be involved in osteoblastic differentiation (By similarity), Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912)


This is TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 protein, from Mouse, contains 716 amino acids, has 1 RanBP2-type Zinc finger.

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF), Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains, The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1


This is RNA-binding protein ZCH321 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 461 amino acids, has 2 C3H1-type Zinc finger.

RNA-binding protein involved in regulation of mRNA stability (PubMed:31743541), Promotes mRNA stabilization by recruiting MKT1 and PBP1 (By similarity), Stabilizes transcripts encoding mitochondrial proteins (PubMed:31743541)


This is Transcription initiation factor IIB protein, from Methanococcus jannaschii, contains 673 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

Stabilizes TBP binding to an archaeal box-A promoter, Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB)


This is tRNA endonuclease ANKZF1 protein, from Bovine, contains 728 amino acids, has 1 C2H2-type Zinc finger.

Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation, The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts, ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs, ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1, Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress


This is E3 ubiquitin-protein ligase TRIM38 protein, from Bovine, contains 460 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity, Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation, Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling, Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity), Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (By similarity)


This is E3 ubiquitin-protein ligase rnf152 protein, from Zebrafish, contains 198 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation, Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability, Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation


This is Nectin-3-like protein protein, from Zebrafish, contains 574 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type


This is DNA topoisomerase 1 protein, from Methanococcus jannaschii, contains 761 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is Transcriptional regulator of yeast form adherence 2 protein, from Yeast, contains 371 amino acids, has 2 C3H1-type Zinc finger.

Transcription factor required for yeast cell adherence to silicone substrate


This is Transcriptional regulator of yeast form adherence 3 protein, from Yeast, contains 494 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Transcriptional regulator GZF3 protein, from Yeast, contains 712 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Probable transcription factor involved in response to fluconazole, LiCl, and copper


This is Transcriptional regulator of yeast form adherence 5 protein, from Yeast, contains 988 amino acids, has 2 C2H2-type Zinc finger.


This is White-opaque regulator 3 protein, from Yeast, contains 641 amino acids, has 1 dksA C4-type Zinc finger.

dksA C4-type

Transcription factor that modulates the white-opaque switch


This is Filamentous growth regulator 15 protein, from Yeast, contains 518 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor involved in the regulation of filamentous growth


This is PAN2-PAN3 deadenylation complex subunit PAN3 protein, from Yeast, contains 697 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1

Belongs to the protein kinase superfamily, PAN3 family


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yeast, contains 613 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)


This is Transcriptional regulator of yeast form adherence 4 protein, from Yeast, contains 286 amino acids, has 2 C2H2-type Zinc finger.