This is Zinc finger protein 24 protein, from Mouse, contains 368 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor required for myelination of differentiated oligodendrocytes, Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state, In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle, Specifically binds to the 5'-TCAT-3' DNA sequence, Has transcription repressor activity in vitro


This is Probable ATP-dependent RNA helicase DDX41 protein, from Mouse, contains 622 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Probable ATP-dependent RNA helicase, Is required during post-transcriptional gene expression, May be involved in pre-mRNA splicing

Belongs to the DEAD box helicase family, DDX41 subfamily


This is E3 SUMO-protein ligase NSE2 protein, from Mouse, contains 247 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination, Is not be required for the stability of the complex, The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks, Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2, Required for recruitment of telomeres to PML nuclear bodies, Required for sister chromatid cohesion during prometaphase and mitotic progression


This is Zinc finger protein with KRAB and SCAN domains 3 protein, from Mouse, contains 553 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy, Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2, Associates with chromatin at the ITGB4 and VEGF promoters (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Stromal membrane-associated protein 1 protein, from Mouse, contains 440 amino acids, has 1 C4-type Zinc finger.

GTPase activating protein that acts on ARF6, Plays a role in clathrin-dependent endocytosis, May play a role in erythropoiesis


This is Ubiquitin carboxyl-terminal hydrolase 3 protein, from Mouse, contains 520 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B, Required for proper progression through S phase and subsequent mitotic entry, May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites, Associates with the chromatin (By similarity)

Belongs to the peptidase C19 family, USP3 subfamily


This is Vacuolar protein sorting-associated protein 11 homolog protein, from Mouse, contains 941 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways, Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion, The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes, The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations, Required for fusion of endosomes and autophagosomes with lysosomes, Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity)


This is Sharpin protein, from Mouse, contains 380 amino acids, has 1 RanBP2-type Zinc finger.

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181), LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181), Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17538631, PubMed:21455173, PubMed:21455180, PubMed:21455181), LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex, The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria, LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin, The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation, Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity)


This is Diacylglycerol kinase gamma protein, from Mouse, contains 788 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:32033984), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:32033984), Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity), Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma (PubMed:32033984), Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (PubMed:32033984)

Belongs to the eukaryotic diacylglycerol kinase family


This is Set1/Ash2 histone methyltransferase complex subunit ASH2 protein, from Mouse, contains 623 amino acids, has 1 PHD-type; atypical Zinc finger, has 1 C4-type Zinc finger.

PHD-type; atypical

Transcriptional regulator (By similarity), Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (By similarity), Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (By similarity), As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity), May play a role in hematopoiesis (By similarity), In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity)


This is AN1-type zinc finger protein 2B protein, from Mouse, contains 257 amino acids, has 2 AN1-type Zinc finger.

Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum (PubMed:24160817, PubMed:26337389, PubMed:26692333), It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum (PubMed:24160817), It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed (PubMed:18467495, PubMed:26337389), May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:24160817, PubMed:26337389), By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)


This is E3 ubiquitin-protein ligase RNF167 protein, from Mouse, contains 347 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway, Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1, Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex, Also involved in protein trafficking and localization, Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2, Does not catalyze ubiquitination of GluA1/GRIA1, Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3, Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B, Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18, Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N


This is ATPase WRNIP1 protein, from Mouse, contains 660 amino acids, has 1 UBZ4-type Zinc finger.

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis, In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased, Also plays a role in the innate immune defense against viruses, Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination, In turn, RIGI transmits the signal through mitochondrial MAVS

Belongs to the AAA ATPase family, RarA/MGS1/WRNIP1 subfamily


This is Sialic acid-binding Ig-like lectin 12 protein, from Mouse, contains 467 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface, In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is Egl nine homolog 1 protein, from Mouse, contains 400 amino acids, has 1 MYND-type; atypical Zinc finger.

MYND-type; atypical

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A, Also hydroxylates HIF2A, Has a preference for the CODD site for both HIF1A and HIF1B, Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex, Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes, EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality, Target proteins are preferentially recognized via a LXXLAP motif


This is E3 ubiquitin-protein ligase RNF126 protein, from Mouse, contains 313 amino acids, has 1 C4-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (By similarity), Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (PubMed:23418353), Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome (By similarity), Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (By similarity), May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (By similarity), May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353), By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (By similarity), May monoubiquitinate AICDA (By similarity)


This is E3 ubiquitin-protein ligase RNF185 protein, from Mouse, contains 192 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity), Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (By similarity), Protects cells from ER stress-induced apoptosis (By similarity), Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (By similarity), Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161), Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity)


This is E3 ubiquitin-protein ligase TRIM63 protein, from Rat, contains 351 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase, Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH, Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids, Inhibits de novo skeletal muscle protein synthesis under amino acid starvation, Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins, May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway, May regulate the organization of myofibrils through TTN in muscle cells


This is Protein odd-skipped-related 2 protein, from Mouse, contains 312 amino acids, has 5 C2H2-type Zinc finger.

Belongs to the Odd C2H2-type zinc-finger protein family


This is FYVE, RhoGEF and PH domain-containing protein 4 protein, from Mouse, contains 766 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Activates MAPK8 (By similarity), Plays a role in regulating the actin cytoskeleton and cell shape, Promotes the formation of lamellipodia


This is E3 ubiquitin-protein ligase TRIM9 protein, from Rat, contains 710 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation, May play a role in regulation of neuronal functions (By similarity), May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle


This is Sialic acid-binding Ig-like lectin 5 protein, from Mouse, contains 569 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, Preferentially binds to alpha-2,3-linked sialic acid, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface


This is E3 ubiquitin-protein ligase SIAH1 protein, from Rat, contains 282 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11786535, PubMed:15951807), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11786535, PubMed:15951807), Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11786535, PubMed:15951807), Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:11786535), Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity), It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription, spermatogenesis and TNF-alpha signaling (By similarity), Has some overlapping function with SIAH2 (By similarity), Induces apoptosis in cooperation with PEG3 (By similarity), Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (PubMed:15951807), GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (PubMed:15951807), Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity), Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1

Belongs to the SINA (Seven in absentia) family


This is Neurotrophin receptor-interacting factor 2 protein, from Mouse, contains 824 amino acids, has 5 C2H2-type Zinc finger.

Transcription regulator which may participate in NGFR/p75(NTR)-mediated apoptosis, Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (By similarity)


This is Peroxisome biogenesis factor 10 protein, from Yeast, contains 419 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 and/or PEX20 receptors from peroxisomes to the cytosol, thereby promoting PEX5 and PEX20 recycling (PubMed:23344950), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 and/or PEX20 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 and/or PEX20 recycling by acting as a E3 ubiquitin-protein ligase (By similarity), When PEX5 or PEX20 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 and/or PEX20 during their passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is E3 ubiquitin-protein ligase TRAF7 protein, from Mouse, contains 594 amino acids, has 1 RING-type Zinc finger, has 1 TRAF-type Zinc finger.

RING-type

TRAF-type

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3, Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators, Induces apoptosis when overexpressed, Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3


This is Protein arginine N-methyltransferase 3 protein, from Mouse, contains 528 amino acids, has 1 C2H2-type Zinc finger.

Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (By similarity), May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (By similarity)

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family


This is Tripartite motif-containing protein 59 protein, from Mouse, contains 403 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:29467473), Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174), Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1, On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway, On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex, In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation, Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (PubMed:29467473)


This is Replication factor A protein 1 protein, from Fission yeast, contains 609 amino acids, has 1 C4-type Zinc finger.

As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair, Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism

Belongs to the replication factor A protein 1 family


This is Neurotrophin receptor-interacting factor 1 protein, from Mouse, contains 828 amino acids, has 5 C2H2-type Zinc finger.

Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis, Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis, Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons, May also regulate expression of neuronal cholesterol biosynthesis genes, Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression


This is E3 ubiquitin-protein ligase NEURL1 protein, from Mouse, contains 574 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory, Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3, Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2, Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway, Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway


This is E3 ubiquitin-protein ligase TRIM7 protein, from Mouse, contains 510 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration, Acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein, Mechanistically, recognizes the C-terminal glutamine-containing motif generated by viral proteases that process the polyproteins and trigger their ubiquitination and subsequent degradation (PubMed:35972292), Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (By similarity), Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (PubMed:30928727), Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response, Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation, Mediates the ubiquitination of the SIN3-HDAC chromatin remodeling complex component BRMS1, Modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells by ubiquitinating NCOA4, leading to its degradation (PubMed:32126128)


This is Metastasis-associated protein MTA3 protein, from Mouse, contains 591 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin, Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels, Contributes to transcriptional repression by BCL6


This is Interleukin-12 subunit beta protein, from Guinea pig, contains 332 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity, IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues, IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines, IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity)


This is Endothelial transcription factor GATA-2 protein, from Rat, contains 480 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells, Binds to the consensus sequence 5'-AGATAG-3' (By similarity), Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P,carinii infection


This is Nuclear receptor subfamily 4 group A member 3 protein, from Human, contains 626 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner, Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity), Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation, Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity), Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression, In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity), Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner, During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity), Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance, Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation, Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity), Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821), In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity), Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1, Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity), Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864), Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration, Inhibits adipogenesis (By similarity), Also participates in cardiac hypertrophy by activating PARP1 (By similarity)

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is Endothelial cell-selective adhesion molecule protein, from Mouse, contains 394 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Can mediate aggregation most likely through a homophilic molecular interaction


This is E3 ubiquitin-protein ligase RNF144A protein, from Mouse, contains 292 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC

Belongs to the RBR family, RNF144 subfamily


This is RING finger protein 37 protein, from Mouse, contains 539 amino acids, has 1 RING-type Zinc finger.

RING-type

May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates


This is Carcinoembryonic antigen-related cell adhesion molecule 2 protein, from Mouse, contains 520 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Isoform 2 may be an adhesion molecule contributing to cell to cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium

Belongs to the immunoglobulin superfamily, CEA family


This is Protein Jade-3 protein, from Human, contains 823 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity


This is Putative high affinity immunoglobulin gamma Fc receptor IB protein, from Human, contains 280 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A, May function in the humoral immune response

Belongs to the immunoglobulin superfamily, FCGR1 family


This is Nectin-2 protein, from Human, contains 538 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV)


This is Estrogen receptor beta protein, from Human, contains 530 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Nuclear receptor ROR-beta protein, from Human, contains 470 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina, Regulates the expression of PTF1A synergistically with FOXN4 (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Zinc finger protein neuro-d4 protein, from Human, contains 387 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor, Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)


This is Zinc finger protein DPF3 protein, from Human, contains 378 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Acts as a regulator of myogenesis in cooperation with HDGFL2 (PubMed:32459350), Mediates the interaction of HDGFL2 with the BAF complex (PubMed:32459350), HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350)


This is Zinc finger protein ubi-d4 protein, from Human, contains 391 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714), Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407), Might also have a role in the development and maturation of lymphoid cells (By similarity), Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684)


This is TATA-binding protein-associated factor 2N protein, from Human, contains 592 amino acids, has 1 RanBP2-type Zinc finger.

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters, Can enter the preinitiation complex together with the RNA polymerase II (Pol II)


This is TRAF family member-associated NF-kappa-B activator protein, from Human, contains 425 amino acids, has 1 UBZ1-type Zinc finger.

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity, Acts as a regulator of TRAF function by maintaining them in a latent state, Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation, Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989), Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989), Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989), May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2


This is Semaphorin-4D protein, from Human, contains 862 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282), Regulates GABAergic synapse development (By similarity), Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity), Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569), Promotes the migration of cerebellar granule cells (PubMed:16055703), Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214), Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703)


This is Transcription factor GATA-6 protein, from Human, contains 595 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924), Regulates SEMA3C and PLXNA2 (PubMed:19666519), Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713), May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778), Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity), Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity), In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit, Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea, Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production, Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG, Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341)


This is Rho guanine nucleotide exchange factor 2 protein, from Human, contains 986 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Activates Rho-GTPases by promoting the exchange of GDP for GTP, May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer, Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026, May stimulate instead the cortical activity of Rac, Inactive toward CDC42, TC10, or Ras-GTPases, Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens, Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S,flexneri cell invasion, Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA, Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase, Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2, Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity), Involved in neuronal progenitor cell division and differentiation (PubMed:28453519), Involved in the migration of precerebellar neurons (By similarity)


This is Histone acetyltransferase KAT5 protein, from Human, contains 513 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29335245, PubMed:29174981, PubMed:33076429, PubMed:32822602), Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270), The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608), The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608), Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602), The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A,Z/H2AZ1 at MYC target genes (By similarity), The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity), Component of a SWR1-like complex that specifically mediates the removal of histone H2A,Z/H2AZ1 from the nucleosome (PubMed:24463511), Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:32034146, PubMed:32817552, PubMed:34077757), Directly acetylates and activates ATM (PubMed:16141325), Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146), Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965), Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996), Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311), Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178), Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity), Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899), Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552), Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757), Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757), Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293), Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293), Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474), Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603), Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912), Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293)


This is Transcription factor IIIB 90 kDa subunit protein, from Human, contains 677 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters, The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA, Isoform 2 is required for transcription of the U6 promoter


This is Ubiquitin carboxyl-terminal hydrolase 13 protein, from Human, contains 863 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD), Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes, Also deubiquitinates USP10, an essential regulator of p53/TP53 stability, In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13, Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD), Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex, Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination, Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains, In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly, Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data


This is B lymphocyte-induced maturation protein 1 homolog protein, from Caenorhabditis elegans, contains 817 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 5; degenerate

Transcription factor which binds to enhancer elements in the promoter region of genes (PubMed:26234645), Regulates the expression of the transcription factor bed-3 to control vulval development (PubMed:26234645, PubMed:32417234), Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage (PubMed:24613396), Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning (PubMed:24968003), Plays a role in male tail tip morphogenesis (PubMed:21408209)


This is Transcription factor unc-3 protein, from Caenorhabditis elegans, contains 491 amino acids, has 1 C5-type Zinc finger.

Transcription factor (PubMed:28056346), Involved in motor neuron fate determination and maintenance, acting as an activator of gene expression in a subset of motor neurons (PubMed:28056346, PubMed:18817768), May act in concert with GFI1 homolog pag-3 in motor neuron fate determination (PubMed:18817768), Required to maintain the expression of transcriptional repressors bnc-1 and cfi-1, which play roles in the cell fate of motor neurons (PubMed:28056346), May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons (PubMed:9502737), Cooperates with jmjd-3,1 and wdr-5,1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442)


This is Probable inactive E3 ubiquitin-protein ligase SINAT6 protein, from Mouse-ear cress, contains 216 amino acids, has 1 SIAH-type Zinc finger.

SIAH-type

Probable inactive E3 ubiquitin-protein ligase that plays a role in regulation of autophagy, Upon starvation, involved in maintaining ATG6 homeostasis by competitively associating with ATG6, a component of the autophagosome complex (PubMed:28351989), Acts as positive regulator of drought stress response, Functions as positive regulator of abscisic acid-mediated stomatal closure (PubMed:24350984)


This is E3 ubiquitin-protein ligase DA2 protein, from Mouse-ear cress, contains 401 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase involved in the regulation of organ and seed size, Acts synergistically with DA1 to regulate seed size, Functions synergistically with DA1 to restrict cell proliferation in the maternal integuments of ovules and developing seeds, Seems to function independently of BB, Possesses E3 ubiquitin-protein ligase activity in vitro (PubMed:24045020), Polyubiquitinates DA1, DAR1 and DAR2, but not DAR3 (PubMed:28167503)


This is E3 ubiquitin-protein ligase AIRP1 protein, from Mouse-ear cress, contains 153 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E2 enzyme UBC8 in vitro (PubMed:20884812, PubMed:15644464), Plays combinatory roles with AIRP2 in the positive regulation of the abscisic acid-mediated drought stress response (PubMed:20884812)


This is Cyclic dof factor 2 protein, from Mouse-ear cress, contains 457 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity), Regulates a photoperiodic flowering response, Transcriptional repressor of 'CONSTANS' expression, The stability of CDF2 is controlled by 'GIGANTEA' and redundantly by ADO3, ADO2 and/or ADO1


This is E3 ubiquitin-protein ligase RDUF2 protein, from Mouse-ear cress, contains 407 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid-dependent drought stress responses, Possesses E3 ubiquitin ligase activity in vitro


This is RING-box protein 1a protein, from Mouse-ear cress, contains 118 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development, Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate, Promotes the neddylation of CUL1


This is Pharynx and intestine in excess protein 1 protein, from Caenorhabditis elegans, contains 335 amino acids, has 2 C3H1-type Zinc finger.

Maternally provided PIE-1 is required for germline cell fate determination, Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline, Required for expression of nos-2 in P4 germline blastomere cells, Inhibits the histone deacetylase activity of hda-1, Represses transcriptional activation of cdk-9 and cit-1,1, which are members of the P-TEFb complex


This is F-box protein dre-1 protein, from Caenorhabditis elegans, contains 936 amino acids, has 1 UBR-type Zinc finger.

UBR-type

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including blmp-1 (PubMed:17336909, PubMed:23431138, PubMed:24613396, PubMed:24968003), Heterochronic protein which is required for the timing of gonad development and epidermal seam cell differentiation (PubMed:17336909), Regulates tail-spike cell death through inhibition of the apoptosis regulator ced-9 (PubMed:23431138)


This is E3 SUMO-protein ligase gei-17 protein, from Caenorhabditis elegans, contains 780 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type smo-1 ligase (PubMed:15654100, PubMed:16701625, PubMed:16549501, PubMed:25475837), Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment (PubMed:25475837), In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation (PubMed:15654100), In embryos, plays a role in determining telomere localization in the nucleus (PubMed:24297748)


This is Zinc finger protein BALDIBIS protein, from Mouse-ear cress, contains 446 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor that, together with JKD, regulates tissue boundaries and asymmetric cell division in roots by a rapid up-regulation of 'SCARECROW' (SCR), thus controlling the nuclear localization of 'SHORT-ROOT' (SHR) and restricting its action (PubMed:25829440), Confines CYCD6 expression to the cortex-endodermis initial/daughter (CEI/CEID) tissues (PubMed:25829440), Binds DNA via its zinc fingers (PubMed:24821766), Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766)


This is Splicing factor U2af 38 kDa subunit protein, from Fruit fly, contains 264 amino acids, has 2 C3H1-type Zinc finger.

Necessary for the splicing of pre-mRNA, Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity)

Belongs to the splicing factor SR family


This is Set1/Ash2 histone methyltransferase complex subunit ASH2 protein, from Fruit fly, contains 556 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Transcriptional regulator, Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development, Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks, Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3, Plays a role in maintenance of transcriptionally active chromatin through down-regulation of histone H1 hyperphosphorylation


This is RNA-binding protein lark protein, from Fruit fly, contains 352 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Essential RNA-binding protein, May be required for circadian repression of eclosion, Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development


This is Protein vein protein, from Fruit fly, contains 623 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ligand for the EGF receptor, Seems to play a role in the global proliferation of wing disc cells and the larval patterning, Shows a strong synergistic genetic interaction with spi, suggesting a molecular interdependence, Required for the development of interveins cells


This is E3 ubiquitin-protein ligase ariadne-1 protein, from Fruit fly, contains 503 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10 (PubMed:10880484, PubMed:21900267, PubMed:29689197), Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex (PubMed:29689197), Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation (PubMed:29689197), Appears to function, at least partially redundantly, with the RBR E3 ligase family member park in nuclear localization and morphology (PubMed:29689197), Likely to function in metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and its heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A (PubMed:21900267)

Belongs to the RBR family, Ariadne subfamily


This is Histone-lysine N-methyltransferase ASHR3 protein, from Mouse-ear cress, contains 497 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone methyltransferase (By similarity), Involved in stamen development

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily


This is Probable E3 ubiquitin-protein ligase ARI1 protein, from Mouse-ear cress, contains 597 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates


This is E3 ubiquitin-protein ligase RZF1 protein, from Mouse-ear cress, contains 320 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that promotes osmotic stress responses, Regulates negatively drought-mediated control of early seedling development, probably by influencing proline content, water loss, membrane ion leakage and the expression of dehydration stress-related genes (e,g, RAB18, RD29A, RD29B, AOX1A, ERD15, ERD1, COR15A, P5CS1 and P5CR)


This is Chaperone protein dnaJ 3 protein, from Mouse-ear cress, contains 420 amino acids, has 1 CR-type Zinc finger.

CR-type

Plays a continuous role in plant development probably in the structural organization of compartments

Belongs to the DnaJ family, A/I subfamily


This is E3 ubiquitin protein ligase DRIP2 protein, from Mouse-ear cress, contains 420 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress, Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A, Functionally redundant with DRIP1


This is Protein OBERON 3 protein, from Mouse-ear cress, contains 733 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Probable transcription factor that functions redundantly with OBE4 in specification of the hypophysis and establishment of the embryonic root (PubMed:22378640), Involved in the activation of ARF5/MP-dependent gene expression during embryonic root meristem initiation (PubMed:22378640), Involved in shoot meristem homeostasis (PubMed:27196372)


This is BTB/POZ and TAZ domain-containing protein 2 protein, from Mouse-ear cress, contains 364 amino acids, has 1 TAZ-type Zinc finger.

TAZ-type

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Plays a key role as a component of the TAC1-mediated telomerase activation pathway certainly by targeting a telomerase repressor to degradation, Seems to occupy an integral position in a complex signaling network that perceives, integrates, and responds to multiple, and sometimes competing, signals, Enhances responses to auxin in postgermination and vegetative development, Also negatively regulates ABA- and sugar-mediated inhibition of the germination, Essential for female and male gametophyte development


This is Helicase-like transcription factor CHR28 protein, from Mouse-ear cress, contains 981 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Probable helicase-like transcription factor involved in transcriptional gene silencing, Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci, May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin (PubMed:25420628), Associates with SUVR2 and functions redundantly with FRG1, Required for the efficient methylation of a broad range of RdDM target loci (PubMed:25425661)

Belongs to the SNF2/RAD54 helicase family, RAD16 subfamily


This is Cold shock domain-containing protein 3 protein, from Mouse-ear cress, contains 301 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Chaperone that binds to RNA, single- (ssDNA) and double-stranded (dsDNA) DNA, and unwinds nucleic acid duplex, Promotes freezing tolerance

Belongs to the cold shock protein (CSP) family


This is E3 ubiquitin-protein ligase SPL1 protein, from Mouse-ear cress, contains 338 amino acids, has 1 RING-type Zinc finger.

RING-type

Possesses E3 ubiquitin-protein ligase activity


This is Glucocorticoid receptor protein, from Common tree shrew, contains 776 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression


This is Major histocompatibility complex class I-related gene protein protein, from Human, contains 341 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells (PubMed:23051753, PubMed:26795251, PubMed:12794138, PubMed:19416870, PubMed:22692454, PubMed:23846752), In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:26795251, PubMed:24695216, PubMed:20581831), Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis, Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (PubMed:24695216), May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin (PubMed:27527800, PubMed:31113973), Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (PubMed:24695216, PubMed:27527800, PubMed:23846752), During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity), Acts as an immune sensor of cancer cell metabolome (PubMed:31959982), May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38,2-DV8*TRAJ31 alpha chain paired with a TRBV25,1*TRBJ2,3 beta chain on a non-MAIT CD8-positive T cell clone (MC,7,G5), triggering T cell-mediated killing of a wide range of cancer cell types (PubMed:31959982)


This is DnaJ homolog subfamily A member 1 protein, from Green monkey, contains 397 amino acids, has 1 CR-type Zinc finger.

CR-type

Co-chaperone for HSPA8/Hsc70, Plays a role in protein transport into mitochondria via its role as co-chaperone, Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis, Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro), Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity)


This is NF-kappa-B essential modulator protein, from Bovine, contains 419 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor, Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways, Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin, Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity, Essential for viral activation of IRF3, Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination


This is Signaling lymphocytic activation molecule protein, from Dog, contains 342 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells, Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates, Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2, However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1, Mediates IL-2-independent proliferation of activated T cells during immune responses and induces IFN-gamma production, Downstreaming signaling involves INPP5D/SHIP1, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production, Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells, Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells, Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells, May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells, May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion, In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage, Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type, In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS), In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A, In conjunction with SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response


This is Peroxisome proliferator-activated receptor alpha protein, from Dog, contains 468 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Key regulator of lipid metabolism, Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC), Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety, Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the ACOX1 and P450 genes, Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2, May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity)


This is Nuclear protein localization protein 4 homolog 2 protein, from Caenorhabditis elegans, contains 529 amino acids, has 1 RanBP2-type Zinc finger.

In association with ufd-1 and ATPase cdc-48,1 and/or cdc-48,2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:22768338), This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:22768338), During S phase and in association with ufd-1, cdc-48,1 and/or cdc-48,2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371), Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564)


This is ARF GTPase-activating protein Git protein, from Fruit fly, contains 731 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1, Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity), Through Pak activation, may positively regulate microtubule nucleation during interphase, May play a role in the regulation of cytokinesis (By similarity), During embryogenesis, promotes proper muscle morphogenesis and proper guidance and targeting of subsets of myotubes (PubMed:18996366), Required for the recruitment of Pak to muscle attachments in the embryo, probably indirectly through pix/dPIX (PubMed:18996366), May be important for brain development (PubMed:25792865)


This is E3 ubiquitin-protein ligase HRD1 protein, from Fruit fly, contains 626 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation, Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins, Also promotes the degradation of normal but naturally short-lived proteins, Protects cells from ER stress-induced apoptosis, Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis


This is Semaphorin-2A protein, from Caenorhabditis elegans, contains 658 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Required for the guidance of axons from neurons, including AIY interneurons, into the nerve ring


This is DNA replication licensing factor mcm-4 protein, from Caenorhabditis elegans, contains 823 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity), Required for DNA replication as well as for the subsequent DNA replication checkpoint controlling entry into M phase in embryos and in postembryonic somatic blast cells (PubMed:21146520), Required for normal growth and viability, specifically via tissue-specific expression in the hypodermis (PubMed:21146520)


This is Endoribonuclease rege-1 protein, from Caenorhabditis elegans, contains 634 amino acids, has 1 C3H1-type Zinc finger.

Endonuclease which binds to the 3'UTR of target mRNAs and induces degradation of the transcript (PubMed:27746047), Negatively regulates the expression of the transcription factor ets-4, which probably controls the expression of lipid metabolism genes (PubMed:27746047), May play a role in the clearance of apoptotic cell corpses (PubMed:18425118)


This is Histone acetyltransferase Tip60 protein, from Fruit fly, contains 541 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic subunit of the Tip60 chromatin-remodeling complex which is involved in DNA repair, Upon induction of DNA double-strand breaks, acetylates phosphorylated histone H2AV in nucleosomes on 'Lys-4' and exchanges it with unmodified H2AV


This is Hepatocyte growth factor-regulated tyrosine kinase substrate protein, from Fruit fly, contains 760 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs, Required during gastrulation and appears to regulate early embryonic signaling pathways, Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs, The MVBs are then trafficked to the lysosome where their contents are degraded


This is B-box zinc finger protein 24 protein, from Mouse-ear cress, contains 248 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Acts as negative regulator of seedling photomorphogenesis and light-regulated inhibition of hypocotyl elongation (PubMed:17605755, PubMed:18540109, PubMed:21685177), BBX24/STO and BBX25/STH function as transcriptional corepressors of HY5 activity, leading to the down-regulation of BBX22 expression, BBX24/STO acts additively with BBX25/STH during de-etiolation and the hypocotyl shade avoidance response (PubMed:23624715), Functions as negative regulator of photomorphogenic UV-B responses by interacting with both COP1 and HY5 (PubMed:22410790), May act as a transcription factor in the salt-stress response (PubMed:12909688)


This is Zinc finger protein ZAT10 protein, from Mouse-ear cress, contains 227 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional repressor involved in abiotic stress responses, Can repress the stress responsive genes DREB1A and LTI78, Probably involved in jasmonate (JA) early signaling response, May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade


This is Leucine-rich repeats and immunoglobulin-like domains protein sma-10 protein, from Caenorhabditis elegans, contains 881 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro, Has a role in regulation of body size


This is Transcription factor che-1 protein, from Caenorhabditis elegans, contains 279 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor essential for the identity of ASE chemosensory neurons, Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase, Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36


This is ATP-dependent RNA helicase glh-2 protein, from Caenorhabditis elegans, contains 974 amino acids, has 6 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Belongs to the DEAD box helicase family, DDX4/VASA subfamily


This is Zinc finger protein with KRAB and SCAN domains 4 protein, from Human, contains 545 amino acids, has 7 C2H2-type Zinc finger.

May be involved in the transcriptional activation of MDM2 and EP300 genes

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase RNF34 protein, from Human, contains 372 amino acids, has 1 FYVE-type Zinc finger, has 1 RING-type Zinc finger.

FYVE-type

RING-type

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins, Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192), May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref,13), Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812), Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127), Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484), Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219)


This is Immunoglobulin superfamily member 8 protein, from Human, contains 613 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function, May regulate proliferation and differentiation of keratinocytes, May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers, May also play a role on integrin-dependent morphology and motility functions, May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain


This is E3 ubiquitin-protein ligase TRIM63 protein, from Human, contains 353 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase, Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH, Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids, Inhibits de novo skeletal muscle protein synthesis under amino acid starvation, Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins, May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway, May regulate the organization of myofibrils through TTN in muscle cells


This is Lethal(3)malignant brain tumor-like protein 2 protein, from Human, contains 705 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Putative Polycomb group (PcG) protein, PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility, Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis, Binds to monomethylated and dimethylated 'Lys-20' on histone H4, Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'


This is Endonuclease 8-like 2 protein, from Human, contains 332 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles), Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Cytoplasmic 60S subunit biogenesis factor ZNF622 protein, from Human, contains 477 amino acids, has 2 U1-type Zinc finger.

Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit


This is Mitochondrial ubiquitin ligase activator of NFKB 1 protein, from Human, contains 352 amino acids, has 1 RING-type Zinc finger.

RING-type

Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793), Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation (PubMed:22410793), Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (PubMed:21597459), Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830), Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395), Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855), May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830), Inhibits cell growth (PubMed:18591963, PubMed:22410793), When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697), Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (PubMed:23399697), Can mediate RIGI sumoylation and disrupt its polyubiquitination (PubMed:23399697)


This is E3 ubiquitin-protein ligase RNF166 protein, from Human, contains 237 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896), In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896), Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228), Also plays a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896), Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896)


This is E3 ubiquitin-protein ligase TRIM52 protein, from Human, contains 297 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type; degenerate

B box-type

(Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV), Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation


This is Zinc finger-containing ubiquitin peptidase 1 protein, from Human, contains 578 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains, Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094), Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527), Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501)

Belongs to the peptidase C78 family, ZUFSP subfamily


This is Endothelial cell-selective adhesion molecule protein, from Human, contains 390 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Can mediate aggregation most likely through a homophilic molecular interaction


This is E3 ubiquitin-protein ligase MIB2 protein, from Human, contains 955 amino acids, has 1 ZZ-type Zinc finger, has 2 RING-type Zinc finger.

ZZ-type

RING-type

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins, Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors


This is PHD finger protein 21A protein, from Human, contains 680 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells, The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier, In the BHC complex, it may act as a scaffold, Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation


This is Transmembrane and immunoglobulin domain-containing protein 2 protein, from Human, contains 282 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Plays a role in cell-cell interaction, cell migration, and angiogenesis, Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation, Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade


This is E3 ubiquitin-protein ligase RNF25 protein, from Human, contains 459 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793), Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (PubMed:36638793), RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793), Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (PubMed:36638793), Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity), May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (PubMed:12748188)


This is Zinc finger protein 669 protein, from Human, contains 464 amino acids, has 9 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger and BTB domain-containing protein 8A protein, from Human, contains 441 amino acids, has 2 C2H2-type Zinc finger.


This is Zinc finger and BTB domain-containing protein 9 protein, from Human, contains 473 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical


This is Synaptotagmin-like protein 4 protein, from Human, contains 671 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary, Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity)


This is Zinc finger protein 524 protein, from Human, contains 264 amino acids, has 4 C2H2-type Zinc finger.


This is Baculoviral IAP repeat-containing protein 7 protein, from Human, contains 298 amino acids, has 1 RING-type Zinc finger.

RING-type

Blocks etoposide-induced apoptosis (PubMed:11162435, PubMed:11322947), Protects against natural killer (NK) cell-mediated killing (PubMed:18034418)


This is Integrator complex subunit 12 protein, from Human, contains 462 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing, The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144), Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267)

Belongs to the Integrator subunit 12 family


This is Zinc finger protein 653 protein, from Human, contains 615 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional repressor, May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity


This is Optineurin protein, from Human, contains 577 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

(Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14,7 or Bluetongue virus, to inhibit innate immune response (PubMed:9488477, PubMed:27538435), During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559)


This is Hepatitis A virus cellular receptor 1 protein, from Human, contains 364 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

(Microbial infection) Plays a positive role in Chikungunya virus cell entry

Belongs to the immunoglobulin superfamily, TIM family


This is E3 ubiquitin-protein ligase RNF183 protein, from Human, contains 192 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230), Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230), May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849)


This is Zinc finger and BTB domain-containing protein 10 protein, from Human, contains 871 amino acids, has 2 C2H2-type Zinc finger.


This is SLAM family member 6 protein, from Human, contains 332 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955), Positive signaling in NK cells implicates phosphorylation of VAV1, NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955), In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity), Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955), Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874), In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response, In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells, Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP, However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity)


This is Tripartite motif-containing protein 44 protein, from Human, contains 344 amino acids, has 1 B box-type Zinc finger.

B box-type

May play a role in the process of differentiation and maturation of neuronal cells (By similarity), May regulate the activity of TRIM17, Is a negative regulator of PAX6 expression (PubMed:26394807)