This is Immunoglobulin heavy variable 4-34 protein, from Human, contains 123 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin heavy constant epsilon protein, from Mouse, contains 421 amino acids, has 4 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Constant region of immunoglobulin heavy chains, Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens, The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen


This is Protein E6 protein, from Human papillomavirus 33, contains 149 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT), The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis, E6 also inhibits immune response by interacting with host IRF3 and TYK2, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway

Belongs to the papillomaviridae E6 protein family


This is Protein E7 protein, from Human papillomavirus type 18, contains 105 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26405230)

Belongs to the papillomaviridae E7 protein family


This is Protein E6 protein, from Bovine papillomavirus type 1, contains 137 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Hyaluronan and proteoglycan link protein 1 protein, from Chicken, contains 355 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix

Secreted, extracellular space, extracellular matrix


This is Serendipity locus protein beta protein, from Fruit fly, contains 356 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 5 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Binds to the consensus DNA sequence 5'-YCAGAGATGCGCA-3'


This is Zinc finger protein 1 protein, from Mouse, contains 402 amino acids, has 7 C2H2-type Zinc finger, has 1 C2H2-type 7; degenerate Zinc finger.

C2H2-type 7; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is 43 kDa receptor-associated protein of the synapse protein, from Pacific electric ray, contains 412 amino acids, has 1 RING-type Zinc finger.

RING-type

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction, It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity)


This is mRNA export factor ICP27 homolog protein, from HHV-3, contains 452 amino acids, has 1 CHC2-type Zinc finger.

Multifunctional regulator of the expression of viral genes that mediates nuclear export of viral intronless mRNAs, This immediate early (EI) protein promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP (By similarity)

Belongs to the HHV-1 ICP27 protein family


This is RAF proto-oncogene serine/threonine-protein kinase protein, from African clawed frog, contains 638 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions, RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity)

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is Membrane glycoprotein US3 protein, from HHV-5, contains 186 amino acids, has 1 Ig-like H-type Immunoglobulin domain.

Ig-like H-type

Retains, but does not degrade MHC class I heterodimers in the endoplasmic reticulum during the immediate-early period of virus infection, thereby impairing their transport and maturation, Forms a complex with beta-2-microglobulin-associated class I heavy chains, which accumulate in the ER, In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes

Belongs to the cytomegalovirus US2 family


This is Unique short US2 glycoprotein protein, from HHV-5, contains 199 amino acids, has 1 Ig-like H-type Immunoglobulin domain.

Ig-like H-type

Participates in the inhibition of the host immune response, Early protein that redirects newly synthesized major histocompatibility complex (MHC) class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction (PubMed:19121997), In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes, Seems so far to be specific for HLA-A, HLA-B, and HFE loci products, Does not interact with HLA-DR or HLA-DM


This is Unique short US9 glycoprotein protein, from HHV-5, contains 247 amino acids, has 1 Ig-like H-type Immunoglobulin domain.

Ig-like H-type

Influences cell-to-cell spread of virus in polarized cells, Promotes dissemination of virus across cell-cell junctions of polarized epithelial cells, maybe through the association with the cytoskeletal matrix

Belongs to the cytomegalovirus US6 family


This is Chaperone protein DnaJ protein, from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity), Necessary for invasion of epithelial cells, secretion of invasion proteins and proliferation within macrophages


This is DNA topoisomerase 1 protein, from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), contains 865 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is DNA topoisomerase 1 protein, from Salmonella typhi, contains 865 amino acids, has 3 C4-type Zinc finger.


This is Thioredoxin 2 protein, from Escherichia coli (strain K12), contains 139 amino acids, has 1  Zinc finger.

Efficient electron donor for the essential enzyme ribonucleotide reductase, Is also able to reduce the interchain disulfide bridges of insulin


This is Ubiquitin-ribosomal protein eS31A fusion protein protein, from Fission yeast, contains 150 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is Protein Tax-1 protein, from HTLV-1, contains 353 amino acids, has 1  Zinc finger.

Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways, Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE), Binding to TRE requires the interaction with CREB1 and CREBBP, Also induces chromatin remodeling of proviral LTR-mediated gene expression by recruiting the histone acetyl transferases CREBBP and EP300 to the chromatin, which results in histone acetylation, Via its interaction with IKK regulatory subunit IKBKG, Tax-1 persistently stimulates I-kappa-B kinase (IKK), resulting in constitutive activation of the transcription factor NF-kappa-B, Induction of the nuclear expression of members of the NFkB family of transcription factors, which leads to up-regulated expression of many gene promoters containing NFkB motifs, These genes include those encoding IL2, IL15, IL2RA and IL15RA, leading to autocrine IL2/IL2RA and IL15/IL15RA loops, The resulting T-cell proliferation leads to malignant transformation and to the development of adult T-cell leukemia (ATL), IL13, known to be linked to leukemogenesis, is also up-regulated by Tax-1, Interaction with PDZ domain-containing proteins induce IL2-independent growth, which may be a factor in multi-step leukemogenesis, Inhibits the action of at least three cellular tumor suppressors p53/TP53, RB1 and DLG1, and suppresses their abilities to dictate apoptosis in primary cells, Required for viral replication (By similarity)

Belongs to the deltaretrovirus Tax protein family


This is Protein Tax-1 protein, from HTLV-1, contains 352 amino acids, has 1  Zinc finger.


This is WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 protein, from Rat, contains 552 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease-inhibitor that contains multiple distinct protease inhibitor domains, Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)


This is RAS guanyl-releasing protein 2 protein, from Rat, contains 608 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP, May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS, Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation, May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway


This is Immunoglobulin superfamily member 11 protein, from Mouse, contains 428 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Functions as a cell adhesion molecule through homophilic interaction, Stimulates cell growth (By similarity)


This is OX-2 membrane glycoprotein homolog protein, from HHV-8, contains 271 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Dramatically stimulates primary monocytes, macrophages, and dendritic cells to produce the inflammatory cytokines interleukin 1-beta, IL-6, monocyte chemoattractant protein 1, and TNF-alpha, The induction of inflammatory cytokine production potentially promotes the cytokine-mediated angiogenic proliferation of KSHV-infected cells


This is Putative E3 ubiquitin-protein ligase ARI6 protein, from Mouse-ear cress, contains 552 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates

Belongs to the RBR family, Ariadne subfamily


This is Ubiquitin-ribosomal protein eS31B fusion protein protein, from Fission yeast, contains 150 amino acids, has 1 C4-type Zinc finger.


This is Ubiquitin carboxyl-terminal hydrolase 22 protein, from Bovine, contains 514 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA, Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator, Recruited to specific gene promoters by activators such as MYC, where it is required for transcription, Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity)

Belongs to the peptidase C19 family, UBP8 subfamily


This is B-cell antigen receptor complex-associated protein alpha chain protein, from Dog, contains 236 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation, Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells, Stimulates SYK autophosphorylation and activation, Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK, Also interacts with and increases activity of some Src-family tyrosine kinases, Represses BCR signaling during development of immature B-cells (By similarity)


This is Immunoglobulin lambda constant 6 protein, from Human, contains 106 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Constant region of immunoglobulin light chains, Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)


This is Ubiquitin-ribosomal protein eS31z fusion protein protein, from Barley, contains 155 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome


This is Ubiquitin-ribosomal protein eS31y fusion protein protein, from Barley, contains 155 amino acids, has 1 C4-type Zinc finger.


This is E3 ubiquitin-protein ligase RING1 protein, from Upland cotton, contains 338 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Promotes polyubiquitination of target proteins


This is Tripartite motif-containing protein 49 protein, from Human, contains 452 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Filobasidiella neoformans, contains 725 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)

Belongs to the Dus family, Dus3 subfamily


This is Vacuolar protein sorting-associated protein 27 protein, from Filobasidiella neoformans, contains 750 amino acids, has 1 FYVE-type; degenerate Zinc finger.

FYVE-type; degenerate

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane


This is Large ribosomal subunit protein eL43A protein, from Baker's yeast, contains 92 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL43 family


This is Large ribosomal subunit protein eL43B protein, from Baker's yeast, contains 92 amino acids, has 1 C4-type Zinc finger.


This is Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2 protein, from Mouse-ear cress, contains 813 amino acids, has 1 C2H2-type Zinc finger.

Polycomb group (PcG) protein, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility, Required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization, Regulates the anteroposterior organization of the endosperm

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is Chaperone protein dnaJ A8, chloroplastic protein, from Rice, contains 447 amino acids, has 1 CR-type Zinc finger.

CR-type

Plays pivotal roles in chloroplast development, Is essential for the regulation of chloroplast development and differentiation


This is FCS-Like Zinc finger 18 protein, from Mouse-ear cress, contains 126 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is Large T antigen protein, from KIPyV, contains 641 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription


T-ag D1-type


This is Large T antigen protein, from MPyV, contains 782 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type


This is Immunoglobulin delta heavy chain protein, from Human, contains 512 amino acids, has 4 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170), IgD is the major antigen receptor isotype on the surface of most peripheral B cells, where it is coexpressed with IgM, The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases, Soluble IgD (sIgD) concentration in serum is below those of IgG, IgA, and IgM but much higher than that of IgE, IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites, After the antigen binds to the B cell receptor, the secreted form sIgD is shut off, IgD is a potent inducer of TNF, IL1B, and IL1RN, IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells, Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:11282392, PubMed:10702483, PubMed:16895553)


This is Immunoglobulin epsilon heavy chain protein, from Human, contains 547 amino acids, has 5 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin gamma-1 heavy chain protein, from Human, contains 449 amino acids, has 4 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like


This is Immunoglobulin mu heavy chain protein, from Human, contains 576 amino acids, has 5 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170), IgM antibodies play an important role in primary defense mechanisms, They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions, The membrane-bound form is found in the majority of normal B cells alongside with IgD, Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases, It may cause death of cells by apoptosis, It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer, After the antigen binds to the B cell receptor, the secreted form is secreted in large amounts (, PubMed:16895553)


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Chinese hamster, contains 275 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG), Binds with intermediate affinity to both IgG2a and IgG2b, Can bind to IgG2a and IgG2b monomers, Does not display binding to IgG1 or IgG3 (By similarity), Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC), Confers protection to lethal influenza virus infection (By similarity), On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (By similarity), Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (By similarity), Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (By similarity), Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE), Binds with low affinity to both the a and b allotypes of IgE, Has also been shown to bind to IgE allotype a only but not to allotype b, Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes, Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821)


This is Polymeric immunoglobulin receptor protein, from Donkey, contains 762 amino acids, has 1 Ig-like V-type 1; required for binding to polymeric IgA and IgM Immunoglobulin domain, has 4 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens, On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells


This is Zinc finger TRAF-type-containing protein 1 protein, from Mouse, contains 399 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type


This is Zinc finger protein 875 protein, from Human, contains 659 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein 28 protein, from Mouse, contains 825 amino acids, has 14 C2H2-type Zinc finger, has 1 C2H2-type 15; degenerate Zinc finger.

C2H2-type 15; degenerate

May be involved in transcriptional regulation, May have a role in embryonic development


This is Tripartite terminase subunit 1 protein, from HHV-1, contains 785 amino acids, has 1 C3H1-type Zinc finger.

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging, Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm, Once the complex reaches the host nucleus, it interacts with the capsid portal vertex, This portal forms a ring in which genomic DNA is translocated into the capsid, TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes

Belongs to the herpesviridae TRM1 protein family


This is Nuclear egress protein 1 protein, from HHV-1, contains 306 amino acids, has 1 CCCH-type Zinc finger.

CCCH-type

Plays an essential role in virion nuclear egress, the first step of virion release from infected cell, Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2, Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space, There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network

Belongs to the herpesviridae NEC1 protein family


This is Envelope glycoprotein C protein, from HHV-1, contains 511 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate, Also plays several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions (By similarity)

Belongs to the herpesviridae glycoprotein C family


This is Putative P4-specific DNA primase protein, from Bacteriophage P4, contains 777 amino acids, has 1 CHC2-type Zinc finger.

This protein acts as a DNA primase generating di- to pentaribonucleotides; the predominant product being the dimer pppApG, It complexes specifically to the P4 origin of replication (ori) and its cis replication region (crr), It also acts as a DNA helicase


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Common tobacco, contains 495 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Transposable element Hobo transposase protein, from Fruit fly, contains 644 amino acids, has 1 BED-type Zinc finger.

BED-type


This is Intracisternal A-particle Pol-related polyprotein protein, from IAP-IL3, contains 814 amino acids, has 1 Integrase-type Zinc finger.

Integrase-type

Belongs to the retroviral Pol polyprotein family


This is Large T antigen protein, from MPyV, contains 777 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type


This is Large T antigen protein, from BFPyV, contains 587 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription (By similarity)


This is Large ribosomal subunit protein eL24 protein, from Halobacterium marismortui, contains 67 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL24 family


This is Unique short US6 glycoprotein protein, from HHV-5, contains 183 amino acids, has 1 Ig-like H-type Immunoglobulin domain.

Ig-like H-type

Inhibits peptide loading of MHC class I molecules by transporters associated with antigen processing (TAP), Does not prevent peptide binding to TAP, but binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1, but not TAP2, Also prevents the conformational rearrangement of TAP induced by peptide binding, In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes


This is Envelope glycoprotein C homolog protein, from BoHV-1, contains 521 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans (By similarity), Plays also a role in host immune evasion by inhibiting the host complement cascade activation


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Social amoeba, contains 154 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 154 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel


This is Large T antigen protein, from BKPyV, contains 691 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription


This is Protein amalgam protein, from Fruit fly, contains 333 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type


This is Serendipity locus protein H-1 protein, from Fruit fly, contains 869 amino acids, has 8 C2H2-type Zinc finger.

May belong to a complex set of multifingered proteins which play an important role in gene activation or regulation at early embryonic stages through a maximal accumulation of their transcripts (or protein product) in the mature oocyte


This is Zinc finger protein 271 protein, from Mouse, contains 580 amino acids, has 18 C2H2-type Zinc finger.

May act to control gene activity during the pachytene stage of meiotic prophase, May function as a transcription activator

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein 44 protein, from Human, contains 663 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 15 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; degenerate


This is Class I histocompatibility antigen, Non-RT1.A alpha-1 chain protein, from Rat, contains 319 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is Class I histocompatibility antigen, F10 alpha chain protein, from Chicken, contains 345 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is T-cell surface glycoprotein CD4 protein, from Rhesus macaque, contains 458 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is Patr class I histocompatibility antigen, CH28 alpha chain protein, from Chimpanzee, contains 346 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Protein OPG185 protein, from VACV, contains 315 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane, The OPG185-OPG040 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation, Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack

Belongs to the orthopoxvirus OPG185 family


This is mRNA export factor ICP27 homolog protein, from HHV-5, contains 744 amino acids, has 1 CHC2-type Zinc finger.

Immediate early (EI) protein that plays many roles during productive infection including regulation of host cell cycle progression, regulation of viral gene expression or nuclear export of intronless viral RNAs, Acts as a transcriptional transactivator via interaction with the cellular transcription elongation factor SUPT6H (PubMed:22171252), In addition, acts as a post-transcriptional transactivator that mediates the nuclear export of unspliced mRNAs via interaction with DDX39B, a component of the cellular mRNA export machinery (PubMed:16478985, PubMed:26178996)

Belongs to the HHV-1 ICP27 protein family


This is Nuclear egress protein 1 protein, from HHV-5, contains 376 amino acids, has 1 CCCH-type Zinc finger.

CCCH-type


This is Zinc finger protein 708 protein, from Human, contains 563 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 182 protein, from Human, contains 639 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Zinc finger protein 22 protein, from Human, contains 224 amino acids, has 5 C2H2-type Zinc finger.

Binds DNA through the consensus sequence 5'-CAATG-3', May be involved in transcriptional regulation and may play a role in tooth formation (By similarity)


This is Zinc finger protein with KRAB and SCAN domains 1 protein, from Human, contains 563 amino acids, has 6 C2H2-type Zinc finger.


This is Zinc finger protein 25 protein, from Human, contains 456 amino acids, has 12 C2H2-type Zinc finger.


This is Zinc finger protein 26 protein, from Human, contains 533 amino acids, has 13 C2H2-type Zinc finger.


This is Zinc finger protein 37A protein, from Human, contains 561 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 10 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate


This is Zinc finger protein 28 protein, from Human, contains 718 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 15 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 4; degenerate


This is Zinc finger protein 43 protein, from Human, contains 809 amino acids, has 19 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 3; degenerate

C2H2-type 4; degenerate


This is Zinc finger protein 30 protein, from Human, contains 623 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 16 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 3; degenerate


This is Zinc finger protein 7 protein, from Human, contains 686 amino acids, has 15 C2H2-type Zinc finger.


This is Zinc finger protein 8 protein, from Human, contains 575 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional repressor, May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins


This is Zinc finger protein 37 protein, from Mouse, contains 594 amino acids, has 12 C2H2-type Zinc finger.

May have a role in regulating spermiogenesis


This is Protein E7 protein, from Human papillomavirus 31, contains 98 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)

Belongs to the papillomaviridae E7 protein family


This is Thyroid hormone receptor beta-B protein, from African clawed frog, contains 414 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

High affinity receptor for triiodothyronine (T3)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is DLA class I histocompatibility antigen, A9/A9 alpha chain protein, from Dog, contains 362 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Patr class II histocompatibility antigen, DO beta chain protein, from Chimpanzee, contains 273 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells, Modifies peptide exchange activity of HLA-DM


This is Retinoic acid receptor alpha protein, from Eastern newt, contains 458 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), Retinoic acid signaling appears to be involved in specifying proximal-distal axis in limb regeneration


This is Retinoic acid receptor gamma protein, from Eastern newt, contains 505 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity)


This is Butyrophilin subfamily 1 member A1 protein, from Bovine, contains 526 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

May function in the secretion of milk-fat droplets, May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane, Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity)

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Pre-mRNA-splicing factor PRP9 protein, from Baker's yeast, contains 530 amino acids, has 2 Matrin-type Zinc finger.

Matrin-type

Matrin-type

mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly


This is Transcription elongation factor S-II protein, from Fruit fly, contains 313 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus


This is DNA helicase/primase protein, from Bacteriophage T3, contains 566 amino acids, has 1 C4-like; zinc ribbon fold Zinc finger.

C4-like; zinc ribbon fold

ATP-dependent DNA helicase and primase essential for viral DNA replication and recombination, The helicase moves 5' -> 3' on the lagging strand template, unwinding the DNA duplex ahead of the leading strand polymerase at the replication fork and generating ssDNA for both leading and lagging strand synthesis, ATP or dTTP hydrolysis propels each helicase domain to translocate sequentially along DNA, Mediates strand transfer when a joint molecule is available and participates in recombinational DNA repair through its role in strand exchange, Primase activity synthesizes short RNA primers at the sequence 5'-GTC-3' on the lagging strand that the polymerase elongates using dNTPs and providing the primase is still present

Belongs to the Teseptimavirus DNA helicase/primase family


This is Zinc finger Y-chromosomal protein 2 protein, from Mouse, contains 777 amino acids, has 12 C2H2-type Zinc finger.

Probable transcriptional activator, Binds to the consensus sequence 5'-AGGCCY-3' (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family, ZFX/ZFY subfamily


This is Zinc finger protein 10 protein, from Human, contains 573 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 9 C2H2-type Zinc finger, has 1 C2H2-type 11; atypical Zinc finger.

C2H2-type 1; atypical

C2H2-type 11; atypical


This is Protein SAN1 protein, from Baker's yeast, contains 610 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays a specific role in mating-type regulation of yeast, by acting post-translationally to control the stability or activity of the SIR4 proteins


This is Envelope glycoprotein C protein, from EHV-4, contains 485 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans, Also plays a role in host immune evasion by inhibiting the host complement cascade activation


This is Envelope glycoprotein C homolog protein, from GaHV-2, contains 501 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

May play an immunoevasive role in the pathogenesis of Marek's disease, It is a candidate for causing the early-stage immunosuppression that occurs after MDHV infection


This is Gag polyprotein protein, from Duplan murine leukemia virus, contains 529 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome, Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome, This binding is dependent on genome dimerization


This is Transcription elongation factor A protein 3 protein, from Mouse, contains 347 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type


This is Small ribosomal subunit protein eS27-like protein, from Rat, contains 84 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eS27 family


This is Large T antigen protein, from MPyV, contains 648 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription


This is E3 ubiquitin-protein ligase IE2 protein, from AcMNPV, contains 408 amino acids, has 1 RING-type Zinc finger.

RING-type

RING-finger E3 ubiquitin ligase that plays an important regulatory role during the initial stages of infection, Migrates to specific nuclear foci early in infection supposely to prepare the sites for viral transcription and replication by targeting and ubiquitinating host proteins, Acts as a transcriptional activator and activates a number of viral promoters including itself, IE1 and the promoter of 39K gene

Belongs to the alphabaculovirus IE2 protein family


This is Protein E6 protein, from Human papillomavirus 39, contains 158 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT), The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis, E6 also inhibits immune response by interacting with host IRF3 and TYK2, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway

Belongs to the papillomaviridae E6 protein family


This is Large T antigen protein, from BPyV, contains 619 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type


This is Hemolin protein, from Cecropia moth, contains 413 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Insect-immune protein, Forms a protein complex at the bacterial surface, Can inhibit hemocyte aggregation


This is Soluble interferon alpha/beta receptor OPG204 protein, from VACV, contains 351 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like V-type

Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1 (PubMed:28877647), Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor

Belongs to the interleukin-1 receptor family


This is B-lymphocyte antigen CD19 protein, from Guinea pig, contains 430 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes, Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity), Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores, Is not required for early steps during B cell differentiation in the blood marrow, Required for normal differentiation of B-1 cells, Required for normal B cell differentiation and proliferation in response to antigen challenges, Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (By similarity)


This is Nitrogen regulatory protein DAL80 protein, from Baker's yeast, contains 269 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Negative regulator of multiple nitrogen catabolic genes including the allantoin pathway genes


This is DNA repair protein complementing XP-A cells homolog protein, from African clawed frog, contains 267 amino acids, has 1  Zinc finger.

Involved in DNA excision repair, Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity)


This is Protein E6 protein, from Human papillomavirus 35, contains 149 amino acids, has 2  Zinc finger.


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Maize, contains 155 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Turnip fern, contains 314 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is DNA repair protein complementing XP-A cells homolog protein, from Fruit fly, contains 296 amino acids, has 1  Zinc finger.


This is Retinoic acid receptor gamma protein, from African clawed frog, contains 476 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity)


This is Envelope glycoprotein C protein, from HHV-1, contains 511 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate, Also plays several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions


This is E3 ubiquitin-protein ligase ICP0 protein, from EHV-1, contains 532 amino acids, has 1 RING-type Zinc finger.

RING-type

Evades nuclear antiviral defenses triggered by dsDNA viruses, Acts during the initial stages of lytic infection and the reactivation of latent viral genome, Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100


This is Transcription initiation factor IIB protein, from African clawed frog, contains 316 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II), Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA, Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex, Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle, Associates with chromatin to core promoter-specific regions, Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element, Modulates transcription start site selection, Exhibits also autoacetyltransferase activity that contributes to the activated transcription


This is Gag polyprotein protein, from Murine leukemia virus (strain DEF27), contains 536 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is E3 ubiquitin-protein ligase sina protein, from Fruit fly, contains 314 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons, Also involved in external sensory organ development

Belongs to the SINA (Seven in absentia) family


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Tobacco hawkmoth, contains 155 amino acids, has 1 C4-type Zinc finger.


This is Protein M2-1 protein, from BRS, contains 186 amino acids, has 1 C3H1-type Zinc finger.

Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription, Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription, Preferentially binds to poly(A)-rich sequences, Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding

Belongs to the pneumoviridae M2-1 protein family


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Beechdrops, contains 493 amino acids, has 1 C4-type Zinc finger.


This is N-chimaerin protein, from Rat, contains 334 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

GTPase-activating protein for p21-rac and a phorbol ester receptor, Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance


This is T-cell-specific surface glycoprotein CD28 homolog protein, from Chicken, contains 221 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Southern Asian dodder, contains 497 amino acids, has 1 C4-type Zinc finger.


This is Large ribosomal subunit protein eL37 protein, from Halobacterium marismortui, contains 57 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL37 family


This is Large ribosomal subunit protein eL42 protein, from Halobacterium marismortui, contains 92 amino acids, has 1 C4-type Zinc finger.

Binds to the 23S rRNA, Binds deacetylated tRNA in the E site; when the tRNA binds a stretch of 7 amino acids are displaced to allow binding

Belongs to the eukaryotic ribosomal protein eL42 family


This is Poliovirus receptor homolog protein, from Green monkey, contains 417 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Mediates NK cell adhesion and triggers NK cell effector functions, Binds two different NK cell receptors: CD96 and CD226, These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell, This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells, May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell (By similarity)


This is Genome polyprotein protein, from Mengo encephalomyocarditis virus (strain 37A), contains 901 amino acids, has 1  Zinc finger.

VP0 precursor is a component of immature procapsids

Belongs to the picornaviruses polyprotein family


This is Zinc finger protein FZF1 protein, from Baker's yeast, contains 299 amino acids, has 5 C2H2-type Zinc finger.


This is Postreplication repair E3 ubiquitin-protein ligase rad18 protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 501 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group, Associates to the E2 ubiquitin conjugating enzyme mus-8/ubc2 to form the mus-8/ubc2-uvs-2/rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA


This is Zinc finger protein MSN4 protein, from Baker's yeast, contains 630 amino acids, has 2 C2H2-type Zinc finger.

Positive transcriptional factor that acts as a component of the stress responsive system, Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc,), Involved in the regulation of the CTT1, DDR2, HSP12 genes


This is V(D)J recombination-activating protein 2 protein, from Rabbit, contains 527 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical

Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination, V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments, DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends, The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps, The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes, The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele, In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1, It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity)


This is Zinc finger BED domain-containing protein 39 protein, from Caenorhabditis elegans, contains 943 amino acids, has 1 BED-type; degenerate Zinc finger.

BED-type; degenerate

Regulates the timing and orientation of distal tip cell migration during gonadal development, May act in parallel to cacn-1 and Rac GTPases to control the anterior and posterior migration of distal tip cells


This is Protein lin-36 protein, from Caenorhabditis elegans, contains 962 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Required to negatively regulate vulval development, Antagonizes Ras-mediated vulval induction, Acts cell autonomously


This is tRNA endonuclease vms-1 protein, from Caenorhabditis elegans, contains 618 amino acids, has 1 C2H2-type Zinc finger.

Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (By similarity), The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (By similarity), Dispensable for viability and growth but is required for protection against oxidative stress and for wild-type life span (PubMed:21070972)


This is Zinc finger protein 93 protein, from Human, contains 620 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 16 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305), Not able to repress expression of all subtypes of L1 elements, Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes, Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs, 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Transcription factor BYE1 protein, from Baker's yeast, contains 594 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Negative regulator of transcription elongation


This is DNA-directed RNA polymerase II subunit RPB9 protein, from Fruit fly, contains 129 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity)

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is Peroxisome proliferator-activated receptor delta protein, from African clawed frog, contains 396 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues, Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid, Once activated by a ligand, the receptor binds to promoter elements of target genes, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the acyl-CoA oxidase gene, Decreases expression of NPC1L1 once activated by a ligand


This is Peroxisome proliferator-activated receptor gamma protein, from African clawed frog, contains 477 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription, It therefore controls the peroxisomal beta-oxidation pathway of fatty acids, Key regulator of adipocyte differentiation and glucose homeostasis, May play a role in the regulation of circadian rhythm (By similarity)


This is DNA repair protein RadA protein, from Bacillus subtilis (strain 168), contains 458 amino acids, has 1 C4-type Zinc finger.

Plays a role in DNA repair (PubMed:9141693, PubMed:11810266), Might stabilize or process Holliday junction intermediates (PubMed:15317759), May work with DisA following methyl methanesulfonate (MMS) but not H(2)O(2) damage; DisA is a DNA integrity scanning protein with c-di-AMP synthase activity

Belongs to the RecA family, RadA subfamily


This is Probable transcriptional regulator NRG2 protein, from Baker's yeast, contains 220 amino acids, has 2 C2H2-type Zinc finger.


This is Structure-specific endonuclease subunit SLX1 protein, from Baker's yeast, contains 304 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA, Has a preference for simple Y, 5'-flap and replication fork-like structures, It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates, Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks, Has Holliday junction resolvase activity in vitro


This is Dof zinc finger protein MNB1A protein, from Maize, contains 238 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence at the MNF1-binding site


This is ADP-ribosylation factor GTPase-activating protein GLO3 protein, from Baker's yeast, contains 493 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for the ADP ribosylation factor (ARF) family, Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum


This is RING finger protein ETP1 protein, from Baker's yeast, contains 585 amino acids, has 1 RING-type Zinc finger, has 1 UBP-type; degenerate Zinc finger.

RING-type

UBP-type; degenerate

May act as a cytoplasmic retention protein with a role in regulating nuclear transport, Binds nuclear localization sequences in vitro, Needed to adapt efficiently to ethanol, either as sole carbon source or as cell stressor, Involved in ethanol-dependent transcriptional activation of several genes and ethanol-induced protein turnover of some proteins


This is Box C/D snoRNA protein 1 protein, from Baker's yeast, contains 366 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis


This is DnaJ protein homolog XDJ1 protein, from Baker's yeast, contains 459 amino acids, has 1 CR-type Zinc finger.

CR-type


This is DNA topoisomerase 1 protein, from Bacillus subtilis (strain 168), contains 691 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is Transcription factor IIIA protein, from Baker's yeast, contains 429 amino acids, has 9 C2H2-type Zinc finger.

Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III, Also binds the transcribed 5S RNA's


This is DNA topoisomerase 1 protein, from Bacillus anthracis, contains 870 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)


This is DNA-dependent ATPase MGS1 protein, from Baker's yeast, contains 587 amino acids, has 1 UBZ4-type Zinc finger.

Involved in the maintenance of proper DNA topology and chromosome integrity via annealing of single-stranded DNA breaks, Modulates DNA polymerase delta during replication or replication-associated repair, May function as a modulator for SGS1 when DNA is damaged

Belongs to the AAA ATPase family, RarA/MGS1/WRNIP1 subfamily


This is Eukaryotic translation initiation factor 2 subunit 2 protein, from Rabbit, contains 333 amino acids, has 1 C4-type Zinc finger.

Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC), Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex, In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B


This is Asparagine-rich zinc finger protein AZF1 protein, from Baker's yeast, contains 914 amino acids, has 4 C2H2-type Zinc finger.

Potential transcription factor; suppressor for a mitochondrial RNA polymerase mutant


This is Nuclear hormone receptor family member nhr-10 protein, from Caenorhabditis elegans, contains 395 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Probable transcription factor that acts in a feed-forward loop with nhr-68 to activate genes involved in the vitamin B12-independent breakdown of the short-chain fatty acid propionate (PubMed:30625328), This pathway is triggered in response to a diet low in vitamin B12, when canonical vitamin B12-dependent propionate breakdown cannot function; the resulting accumulation of propionate is probably sensed by nhr-10 and/or nhr-68 (PubMed:30625328)

Belongs to the nuclear hormone receptor family


This is Class II receptor tyrosine kinase protein, from Sponge, contains 605 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is Protein GZF3 protein, from Baker's yeast, contains 551 amino acids, has 1 GATA-type Zinc finger.

GATA-type


This is DNA topoisomerase 1 protein, from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), contains 868 amino acids, has 3 C4-type Zinc finger.


This is Early growth response protein 3 protein, from Rat, contains 387 amino acids, has 3 C2H2-type Zinc finger.

Probable transcription factor involved in muscle spindle development

Belongs to the EGR C2H2-type zinc-finger protein family


This is Transcriptional regulatory protein GAT1 protein, from Baker's yeast, contains 510 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Positive regulator of multiple nitrogen catabolic genes


This is Pre-mRNA-splicing factor SAD1 protein, from Baker's yeast, contains 448 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Promotes the assembly of newly synthesized U4 snRNA into the U4/U6 snRNP particle, Required for splicing of pre-mRNA


This is Killer cell immunoglobulin-like receptor 2DL2 protein, from Human, contains 348 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes, Inhibits the activity of NK cells thus preventing cell lysis

Belongs to the immunoglobulin superfamily


This is Transcription factor GATA-5 protein, from Chicken, contains 391 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Probably involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression, Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions


This is Formamidopyrimidine-DNA glycosylase protein, from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is Ecdysone-induced protein 78C protein, from Fruit fly, contains 862 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Induces the early late puff 78C which triggers puparium formation and development

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Transcription factor IIIB 70 kDa subunit protein, from Yeast, contains 556 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase III transcription, Interacts with TBP, Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC


This is T-cell surface glycoprotein CD4 protein, from Rabbit, contains 459 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is DNA topoisomerase 1 protein, from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8), contains 633 amino acids, has 1 C4-type Zinc finger.


This is DNA topoisomerase 1 protein, from Mycoplasmoides genitalium, contains 709 amino acids, has 2 C4-type Zinc finger.


This is Programmed cell death protein 2 protein, from Rat, contains 343 amino acids, has 1 MYND-type; atypical Zinc finger.

MYND-type; atypical

May be a DNA-binding protein with a regulatory function, May play an important role in cell death and/or in regulation of cell proliferation


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from White lupine, contains 155 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome


This is Protein TIS11 protein, from Fruit fly, contains 436 amino acids, has 2 C3H1-type Zinc finger.


This is Interleukin-12 subunit beta protein, from Rhesus macaque, contains 328 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity, IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues, IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines, IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity)


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Rape, contains 489 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Soybean, contains 432 amino acids, has 1 C4-type Zinc finger.


This is Large ribosomal subunit protein bL32 protein, from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1), contains 60 amino acids, has 1 C4-type Zinc finger.

Forms a cluster with L17 and L22, and with L22, a pair of 'tweezers' that hold together all the domains of the 23S rRNA, Interacts with the antibiotic troleandomycin which blocks the peptide exit tunnel

Belongs to the bacterial ribosomal protein bL32 family


This is Vitamin D3 receptor protein, from Japanese quail, contains 448 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells, Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR, The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity), Plays a central role in calcium homeostasis (By similarity), Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)


This is Nuclear hormone receptor FTZ-F1 protein, from Silk moth, contains 534 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

May play an important role in development

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is Ecdysone receptor protein, from Silk moth, contains 606 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone, Binds to ecdysone response elements (ECRES), May play a role in the implementation of the choriogenic program at the end of vitellogenesis


This is Ecdysone receptor protein, from Tobacco hawkmoth, contains 556 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone, Binds to ecdysone response elements (ECRES)


This is Ecdysone-inducible protein E75 protein, from Greater wax moth, contains 711 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor possibly involved in the regulation of genes in the ecdysteroid cascade


This is Estrogen receptor protein, from Israeli tilapia, contains 583 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Estrogen receptor protein, from Atlantic salmon, contains 535 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is T-cell antigen CD7 protein, from Mouse, contains 210 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Peroxisomal biogenesis factor 2 protein, from Pleurage anserina, contains 554 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity), PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity), Involved in caryogamy (nuclear fusion), a process required for sexual sporulation (PubMed:7600573)


This is Retinoic acid receptor RXR-gamma protein, from African clawed frog, contains 470 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Ubiquitin-ribosomal protein eS31y fusion protein protein, from Rice, contains 155 amino acids, has 1 C4-type Zinc finger.

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is Zinc finger protein 80 protein, from Human, contains 273 amino acids, has 6 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 3; atypical

May be involved in transcriptional regulation


This is Zinc finger protein 81 protein, from Human, contains 661 amino acids, has 12 C2H2-type Zinc finger.


This is Zinc finger protein 83 protein, from Human, contains 516 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Ciliary neurotrophic factor receptor subunit alpha protein, from Chicken, contains 362 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to CNTF (GPA), The alpha subunit provides the receptor specificity

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Zinc finger protein 75D protein, from Human, contains 510 amino acids, has 5 C2H2-type Zinc finger.


This is Zinc finger protein 136 protein, from Human, contains 540 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 13 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain


This is Zinc finger protein 134 protein, from Human, contains 427 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Japanese black pine, contains 321 amino acids, has 1 C4-type Zinc finger.


This is Late endosome and vacuole interface protein 11 protein, from Baker's yeast, contains 860 amino acids, has 1 BED-type Zinc finger.

BED-type

Involved in vacuolar processing and morphology


This is Zinc finger protein GIS2 protein, from Baker's yeast, contains 153 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

May act in the sexual differentiation pathway


This is J protein JJJ1 protein, from Baker's yeast, contains 590 amino acids, has 2 C2H2-type Zinc finger.


This is FKBP12-associated protein 1 protein, from Baker's yeast, contains 965 amino acids, has 1 RING-type; degenerate Zinc finger, has 5 NF-X1-type Zinc finger.

RING-type; degenerate

May play a role in transcription regulation


This is Formamidopyrimidine-DNA glycosylase protein, from Neisseria meningitidis serogroup B (strain MC58), contains 275 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is Myelin-oligodendrocyte glycoprotein protein, from Bovine, contains 246 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Mediates homophilic cell-cell adhesion (By similarity), Minor component of the myelin sheath, May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Formamidopyrimidine-DNA glycosylase protein, from Mycoplasmoides genitalium, contains 284 amino acids, has 1 FPG-type Zinc finger.

FPG-type