This is Transcriptional activator protein protein, from ACMV, contains 135 amino acids, has 1  Zinc finger.

Strong activator of the late viral genes promoters, Enhances the expression of the capsid protein and nuclear shuttle protein, Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs, Suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway, Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense, Determines pathogenicity (By similarity)

Belongs to the geminiviridae transcriptional activator protein family


This is SMH class II histocompatibility antigen, beta-1 chain protein, from Middle East blind mole rat, contains 258 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Capsid protein protein, from Soybean chlorotic mottle virus, contains 441 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Self assembles to form an icosahedral capsid, about 50 nm in diameter, nm, composed of 420 subunits of the viral capsid protein, The capsid encapsulates the genomic dsDNA, Following virus entry into host cell, provides nuclear import of the viral genome, Virus particles do not enter the nucleus, but dock at the nuclear membrane through the interaction with host importins (By similarity)

Belongs to the caulimoviridae capsid protein family


This is SLA class II histocompatibility antigen, DQ haplotype C alpha chain protein, from Pig, contains 254 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is SLA class II histocompatibility antigen, DQ haplotype D alpha chain protein, from Pig, contains 255 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is SLA class II histocompatibility antigen, DQ haplotype C beta chain protein, from Pig, contains 261 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is SLA class II histocompatibility antigen, DQ haplotype D beta chain protein, from Pig, contains 258 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Gag polyprotein protein, from FIV, contains 450 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA, Binds these RNAs through its zinc fingers (By similarity)

Belongs to the feline lentivirus group gag polyprotein family


This is Zinc finger protein 58 protein, from Mouse, contains 489 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May have a role during differentiation processes

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein 59 protein, from Mouse, contains 653 amino acids, has 16 C2H2-type Zinc finger.


This is Zinc finger protein 60 protein, from Mouse, contains 707 amino acids, has 19 C2H2-type Zinc finger.


This is Zinc finger protein 823 protein, from Human, contains 610 amino acids, has 15 C2H2-type Zinc finger, has 1 C2H2-type 11; atypical Zinc finger.

C2H2-type 11; atypical

May be involved in transcriptional regulation


This is Tripartite terminase subunit 1 protein, from HHV-5, contains 850 amino acids, has 1 C3H1-type Zinc finger.

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging, Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm, Once the complex reaches the host nucleus, it interacts with the capsid portal vertex, This portal forms a ring in which genomic DNA is translocated into the capsid, TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes

Belongs to the herpesviridae TRM1 protein family


This is Viral Fc-gamma receptor-like protein UL119 protein, from HHV-5, contains 345 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Serves as a receptor for the Fc part of human IgG, May thus be involved in interfering with host Ig-mediated immune responses


This is Gag polyprotein protein, from SA-OMVV, contains 446 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Belongs to the Ovine/caprine lentivirus group gag polyprotein family


This is Zinc finger protein 14 protein, from Human, contains 642 amino acids, has 17 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 2; degenerate

C2H2-type 4; atypical


This is DNA primase protein, from HHV-5, contains 946 amino acids, has 1 CHC2-type Zinc finger.

Essential component of the helicase/primase complex, Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis, The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs

Belongs to the herpesviridae DNA primase family


This is Protein E6 protein, from Human papillomavirus 31, contains 149 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT), The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis, E6 also inhibits immune response by interacting with host IRF3 and TYK2, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway

Belongs to the papillomaviridae E6 protein family


This is Tripartite terminase subunit 1 protein, from BoHV-2, contains 664 amino acids, has 1 C3H1-type Zinc finger.


This is Chaperone protein DnaJ protein, from Bacillus subtilis (strain 168), contains 375 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Transcription factor IIIA protein, from Kenyan clawed frog, contains 339 amino acids, has 9 C2H2-type Zinc finger.

Involved in ribosomal large subunit biogenesis (By similarity), Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III (By similarity), Also binds the transcribed 5S RNA's (PubMed:2331751)


This is T-cell surface glycoprotein CD3 gamma chain protein, from Sheep, contains 147 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways, In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface, Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G


This is DLA class II histocompatibility antigen, DR-1 beta chain protein, from Dog, contains 266 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Retinoic acid receptor beta protein, from Eastern newt, contains 158 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Envelope glycoprotein C homolog protein, from MeHV-1, contains 489 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Belongs to the herpesviridae glycoprotein C family


This is Gastrula zinc finger protein 5-1 protein, from African clawed frog, contains 445 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 7 C2H2-type Zinc finger.

C2H2-type 1; atypical


This is Gag polyprotein protein, from FIV, contains 450 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Formamidopyrimidine-DNA glycosylase protein, from Bacillus firmus, contains 274 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is RING finger protein Z protein, from LCMV, contains 72 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a crucial role in virion assembly and budding, Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L, Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP, The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z (By similarity)

Belongs to the arenaviridae Z protein family


This is RING finger protein Z protein, from LCMV, contains 51 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Protein E6 protein, from Human papillomavirus 43, contains 155 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation, In turn, apoptosis induced by DNA damage is inhibited, E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Protein E6 protein, from Human papillomavirus 44, contains 150 amino acids, has 2  Zinc finger.


This is H-2 class II histocompatibility antigen, E-Q beta chain protein, from Mouse, contains 264 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is RLA class II histocompatibility antigen, DP beta chain protein, from Rabbit, contains 257 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Ig alpha-1 chain C region protein, from Western lowland gorilla, contains 353 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig alpha is the major immunoglobulin class in body secretions, It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system (By similarity)


This is Immunoglobulin lambda-like polypeptide 1 protein, from Mouse, contains 209 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Myelin protein P0 protein, from Horn shark, contains 246 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae


This is Protein OPG185 protein, from VACV, contains 315 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane, The OPG185-OPG040 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation, Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack

Belongs to the orthopoxvirus OPG185 family


This is DNA-directed RNA polymerase 30 kDa polypeptide protein, from VACV, contains 259 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates, Responsible for the transcription of early, intermediate and late genes, DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG134, thereby allowing the early genes transcription, Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase

Belongs to the poxviridae DNA-directed RNA polymerase 30 kDa subunit family


This is Protein E6 protein, from Human papillomavirus 45, contains 158 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 45, contains 106 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)

Belongs to the papillomaviridae E7 protein family


This is Capsid protein protein, from AbMV, contains 251 amino acids, has 1  Zinc finger.

Encapsidates the viral DNA into characteristic twinned ('geminate') particles, Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus, The CP of bipartite geminiviruses is not required for cell-to-cell or systemic movement

Belongs to the geminiviridae capsid protein family


This is Transcriptional activator protein protein, from AbMV, contains 129 amino acids, has 1  Zinc finger.

Strong activator of the late viral genes promoters, Enhances the expression of the capsid protein and nuclear shuttle protein, Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs, Suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway, Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense, Determines pathogenicity (By similarity)


This is Protein E6 protein, from Human papillomavirus 57, contains 153 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Rhpv 1, contains 191 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 57, contains 92 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Rhpv 1, contains 113 amino acids, has 1  Zinc finger.


This is Chaperone protein DnaJ protein, from Caulobacter crescentus, contains 385 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Protein E6 protein, from Human papillomavirus 47, contains 156 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Protein E7 protein, from Human papillomavirus 47, contains 103 amino acids, has 1  Zinc finger.


This is Fasciclin-2 protein, from American grasshopper, contains 898 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Neuronal recognition molecule, Involved in a pathway recognition for axons during the development of nerve fascicles


This is Envelope glycoprotein C homolog protein, from GaHV-2, contains 501 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

May play an immunoevasive role in the pathogenesis of Marek's disease, It is a candidate for causing the early-stage immunosuppression that occurs after MDHV infection


This is Antigen-presenting glycoprotein CD1d protein, from Cottontail rabbit, contains 275 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells


This is Class II histocompatibility antigen, B-L beta chain protein, from Chicken, contains 231 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Gag polyprotein protein, from MVV, contains 442 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Encapsulates and protects viral dimeric unspliced genomic RNA (gRNA), Binds these RNAs through its zinc fingers, Acts as a nucleic acid chaperone which is involved in rearrangement of nucleic acid secondary structure during gRNA retrotranscription, Also facilitates template switch leading to recombination


CCHC-type

CCHC-type


This is Cell surface glycoprotein gp42 protein, from Rat, contains 233 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like


This is GATA-binding factor 1-A protein, from African clawed frog, contains 359 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcription factor that acts synergistically with tal1/scl and lmo2 to specify embryonic dorsal mesoderm to a hematopoietic fate


This is GATA-binding factor 1-B protein, from African clawed frog, contains 364 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type


This is Putative adenylate cyclase regulatory protein protein, from Trypanosoma brucei brucei, contains 630 amino acids, has 1 RING-type Zinc finger.

RING-type

May be involved in the postranscriptional regulation of genes in VSG expression sites


This is Major immediate early protein protein, from AcMNPV, contains 321 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays some regulatory role in both viral DNA replication and transcriptional transactivation


This is GATA-binding factor 2 protein, from Chicken, contains 466 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator which probably serves as a general switch factor for cell-specific development, It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes


This is Zinc finger protein 239 protein, from Mouse, contains 201 amino acids, has 7 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is DNA repair protein RadA protein, from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), contains 460 amino acids, has 1 C4-type Zinc finger.

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks, Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster, Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB, Does not have RecA's homology-searching function

Belongs to the RecA family, RadA subfamily


This is Protein E6 protein, from Human papillomavirus 56, contains 155 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation, In turn, apoptosis induced by DNA damage is inhibited, E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Protein E7 protein, from Human papillomavirus 39, contains 109 amino acids, has 1  Zinc finger.


This is V(D)J recombination-activating protein 2 protein, from Chicken, contains 528 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical

Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination, V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments, DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends, In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1, It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity)


This is Interleukin-1-binding protein protein, from VACV, contains 326 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

May reduce the host inflammatory response by interacting with inteleukin-1 beta (Il1b) and thus decreasing the association between IL1B and its cellular receptor

Belongs to the interleukin-1 receptor family


This is Protein E6 protein, from Human papillomavirus type 2a, contains 153 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 2a, contains 92 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)


This is Tripartite terminase subunit 1 protein, from HHV-4, contains 685 amino acids, has 1 C3H1-type Zinc finger.

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging, Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm, Once the complex reaches the host nucleus, it interacts with the capsid portal vertex, This portal forms a ring in which genomic DNA is translocated into the capsid, TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes


This is Putative adenylate cyclase regulatory protein protein, from Trypanosoma equiperdum, contains 630 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Protein E6 protein, from Human papillomavirus 51, contains 151 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT), The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis, E6 also inhibits immune response by interacting with host IRF3 and TYK2, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway


This is Protein E6 protein, from Human papillomavirus 58, contains 149 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus type 5b, contains 157 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Protein E7 protein, from Human papillomavirus 58, contains 98 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 51, contains 101 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 5b, contains 103 amino acids, has 1  Zinc finger.


This is Replicase polyprotein 1ab protein, from MHV, contains 500 amino acids, has 1 C4-type Zinc finger.

Non-structural protein 1: binds to the 40S ribosomal subunit and inhibits host translation, The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation, By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (By similarity)

Belongs to the coronaviruses polyprotein 1ab family


This is DNA repair protein complementing XP-A cells homolog protein, from Chicken, contains 267 amino acids, has 1  Zinc finger.

Involved in DNA excision repair, Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity)


This is Protein E6 protein, from Human papillomavirus 42, contains 150 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 35, contains 99 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 42, contains 93 amino acids, has 1  Zinc finger.


This is Capsid protein protein, from PYMV, contains 251 amino acids, has 1  Zinc finger.

Encapsidates the viral DNA into characteristic twinned ('geminate') particles, Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus, The CP of bipartite geminiviruses is not required for cell-to-cell or systemic movement


This is Capsid protein protein, from TYLCV, contains 260 amino acids, has 1  Zinc finger.

Encapsidates the viral genome into characteristic twinned ('geminate') particles, Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus, Plays a role in protection of the genome from degradation, virus acquisition and transmission by insect vectors, infectivity, and systemic movement, The CP of monopartite geminiviruses is absolutely essential for virus movement


This is Transcriptional activator protein protein, from PYMV, contains 129 amino acids, has 1  Zinc finger.

Strong activator of the late viral genes promoters, Enhances the expression of the capsid protein and nuclear shuttle protein, Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs, Suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway, Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense, Determines pathogenicity (By similarity)

Belongs to the geminiviridae transcriptional activator protein family


This is Transcriptional activator protein protein, from TYLCV, contains 135 amino acids, has 1  Zinc finger.

Strong activator of the late viral genes promoters, Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs, TrAP suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway, Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense, Determines pathogenicity (By similarity)


This is Transcriptional activator protein protein, from TYLCSV, contains 135 amino acids, has 1  Zinc finger.


This is Probable E3 ubiquitin-protein ligase IE1 protein, from BoHV-4, contains 285 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

Controls the expression of later classes of genes and also of the IE genes (Potential), E3 ubiquitin-protein ligase (Probable), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Capsid protein protein, from SLCV, contains 251 amino acids, has 1  Zinc finger.


This is Transcriptional activator protein protein, from SLCV, contains 131 amino acids, has 1  Zinc finger.


This is Posterior protein protein, from African clawed frog, contains 555 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

This protein is expressed exclusively in posterior mesoderm and ectoderm of early embryos suggesting a possible role in organization of anteroposterior axis


This is Protein E6 protein, from Human papillomavirus type 41, contains 156 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 41, contains 114 amino acids, has 1  Zinc finger.


This is T-cell surface glycoprotein CD3 epsilon chain protein, from Dog, contains 202 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways, In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development, Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E, Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region


This is Transcription factor TFIIS homolog protein, from Ba71V, contains 243 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Putative initiation factor, Necessary for efficient transcription elongation past template-encoded arresting sites


This is Protein E6 protein, from Human papillomavirus type ME180, contains 158 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type ME180, contains 110 amino acids, has 1  Zinc finger.


This is Carbamoyltransferase HypF protein, from Rhizobium leguminosarum bv. viciae, contains 759 amino acids, has 2 C4-type Zinc finger.

Involved in the maturation of [NiFe] hydrogenases, Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases, HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide

Belongs to the carbamoyltransferase HypF family


This is E3 ubiquitin-protein ligase ICP0 protein, from HHV-2, contains 825 amino acids, has 1 RING-type Zinc finger.

RING-type

Evades nuclear antiviral defenses triggered by dsDNA viruses, Acts during the initial stages of lytic infection and the reactivation of latent viral genome, Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100, Prevents antiviral response to viral DNA induced by IFI16 by degrading it, Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells


This is Chaperone protein DnaJ protein, from Borrelia burgdorferi, contains 364 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Protein E6 protein, from Human papillomavirus 14, contains 171 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 20, contains 165 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 21, contains 168 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 25, contains 161 amino acids, has 2  Zinc finger.


This is Nuclear egress protein 1 protein, from HHV-6 variant A, contains 264 amino acids, has 1 CCCH-type Zinc finger.

CCCH-type

Plays an essential role in virion nuclear egress, the first step of virion release from infected cell, Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2, Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space, There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network

Belongs to the herpesviridae NEC1 protein family


This is mRNA export factor ICP27 homolog protein, from EHV-1, contains 470 amino acids, has 1 CHC2-type Zinc finger.

Multifunctional regulator of the expression of viral genes that mediates nuclear export of viral intronless mRNAs, This immediate early (EI) protein promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP (By similarity)

Belongs to the HHV-1 ICP27 protein family


This is E3 ubiquitin-protein ligase ICP0 protein, from SuHV-1, contains 410 amino acids, has 1 RING-type Zinc finger.

RING-type

Evades nuclear antiviral defenses triggered by dsDNA viruses, Acts during the initial stages of lytic infection and the reactivation of latent viral genome, Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100


This is T-cell surface glycoprotein CD3 epsilon chain protein, from Sheep, contains 192 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is E3 ubiquitin-protein ligase ICP0 protein, from BoHV-1, contains 676 amino acids, has 1 RING-type Zinc finger.

RING-type


This is DNA primase protein, from Rickettsia prowazekii (strain Madrid E), contains 593 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is Outer capsid protein sigma-3 protein, from T2J, contains 365 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3

Belongs to the orthoreovirus sigma-3 protein family


This is T-cell surface glycoprotein CD8 alpha chain protein, from Bornean orangutan, contains 198 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex, The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs), This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells, In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells, CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells


This is T-cell surface glycoprotein CD8 beta chain protein, from Bornean orangutan, contains 210 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex, The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched, Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs), Additionally, plays a critical role in thymic selection of CD8+ T-cells


This is Beta-2-microglobulin protein, from Horse, contains 118 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system (By similarity)

Belongs to the beta-2-microglobulin family


This is Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2 protein, from Caenorhabditis elegans, contains 455 amino acids, has 1 RTR1-type Zinc finger.

Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation


This is Tripartite terminase subunit 1 protein, from MuHV-1, contains 798 amino acids, has 1 C3H1-type Zinc finger.

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging, Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm, Once the complex reaches the host nucleus, it interacts with the capsid portal vertex, This portal forms a ring in which genomic DNA is translocated into the capsid, TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes

Belongs to the herpesviridae TRM1 protein family


This is Chaperone protein DnaJ protein, from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787), contains 374 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Protein E6 protein, from MmPV, contains 153 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response

Belongs to the papillomaviridae E6 protein family


This is Protein E6 protein, from MnPV, contains 135 amino acids, has 2  Zinc finger.


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Garden asparagus, contains 118 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is T-cell surface glycoprotein CD8 alpha chain protein, from Bovine, contains 242 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Gag polyprotein protein, from FIV, contains 449 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA, Binds these RNAs through its zinc fingers (By similarity)

Belongs to the feline lentivirus group gag polyprotein family


This is DNA primase protein, from Buchnera aphidicola subsp. Schizaphis graminum (strain Sg), contains 579 amino acids, has 1 CHC2-type Zinc finger.


This is E3 ubiquitin-protein ligase LAP protein, from SWPV, contains 155 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell, Binds target molecules through transmembrane interaction, The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed

Belongs to the poxviridae LAP protein family


This is E3 ubiquitin-protein ligase IE2 protein, from OpMNPV, contains 405 amino acids, has 1 RING-type Zinc finger.

RING-type

RING-finger E3 ubiquitin ligase that plays an important regulatory role during the initial stages of infection, Migrates to specific nuclear foci early in infection supposely to prepare the sites for viral replication by targeting and ubiquitinating host proteins

Belongs to the alphabaculovirus IE2 protein family


This is Sporulation protein SPS18 protein, from Baker's yeast, contains 300 amino acids, has 1 C4-type Zinc finger.


This is Opioid-binding protein/cell adhesion molecule protein, from Rat, contains 345 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Binds opioids in the presence of acidic lipids; probably involved in cell contact

Belongs to the immunoglobulin superfamily, IgLON family


This is Putative RNA-binding protein involved in heterochromatin assembly protein, from Baker's yeast, contains 719 amino acids, has 2 RanBP2-type Zinc finger.

May play a role in chromatin organization


This is Protein M2-1 protein, from TRTV, contains 186 amino acids, has 1 C3H1-type Zinc finger.

Essential for viral replication in vivo (By similarity), Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding (By similarity)

Belongs to the pneumoviridae M2-1 protein family


This is Envelope glycoprotein C homolog protein, from GaHV-2, contains 501 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

May play an immunoevasive role in the pathogenesis of Marek's disease, It is a candidate for causing the early-stage immunosuppression that occurs after MDHV infection

Belongs to the herpesviridae glycoprotein C family


This is DNA primase protein, from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787), contains 596 amino acids, has 1 CHC2-type Zinc finger.


This is T-cell surface glycoprotein CD8 alpha chain protein, from Dog, contains 239 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Intercellular adhesion molecule 1 protein, from Dog, contains 528 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity)

Belongs to the immunoglobulin superfamily, ICAM family


This is DNA-directed RNA polymerase 30 kDa polypeptide protein, from VARV, contains 259 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates, Responsible for the transcription of early, intermediate and late genes, DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG134, thereby allowing the early genes transcription, Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase

Belongs to the poxviridae DNA-directed RNA polymerase 30 kDa subunit family


This is Protein OPG185 protein, from VARV, contains 313 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane, The OPG185-OPG040 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation, Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack

Belongs to the orthopoxvirus OPG185 family


This is Gex-3-interacting protein 13 protein, from Caenorhabditis elegans, contains 691 amino acids, has 2 BED-type Zinc finger.

BED-type

BED-type


This is General transcription factor IIH subunit 2 protein, from Caenorhabditis elegans, contains 376 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription


This is Immunoglobulin domain and leucine-rich repeat-containing protein 2 protein, from Caenorhabditis elegans, contains 773 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Transcriptional activator VP30 protein, from MARV, contains 281 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation, This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity)

Belongs to the filoviridae transcriptional activator VP30 family


This is Chaperone protein DnaJ protein, from Streptococcus lactis, contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is ATP-dependent Clp protease ATP-binding subunit ClpE protein, from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), contains 752 amino acids, has 1 C4-type Zinc finger.

Could be necessary for degrading proteins generated by certain types of stress

Belongs to the ClpA/ClpB family, ClpE subfamily


This is Gag polyprotein protein, from MVV, contains 442 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Encapsulates and protects viral dimeric unspliced genomic RNA (gRNA), Binds these RNAs through its zinc fingers, Acts as a nucleic acid chaperone which is involved in rearrangement of nucleic acid secondary structure during gRNA retrotranscription, Also facilitates template switch leading to recombination

Belongs to the Ovine/caprine lentivirus group gag polyprotein family


This is Helper of Tim protein 13 protein, from Baker's yeast, contains 116 amino acids, has 1 CHY-type; degenerate Zinc finger.

CHY-type; degenerate

Required for the assembly or recycling of the small Tim proteins in the mitochondrial intermembrane, thereby participating in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, Probably acts by facilitating the formation of disulfide bonds in small Tim proteins


This is Capsid protein protein, from ToMoV, contains 251 amino acids, has 1  Zinc finger.

Encapsidates the viral DNA into characteristic twinned ('geminate') particles, Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus, The CP of bipartite geminiviruses is not required for cell-to-cell or systemic movement

Belongs to the geminiviridae capsid protein family


This is Transcriptional activator protein protein, from ToLCV, contains 135 amino acids, has 1  Zinc finger.

Strong activator of the late viral genes promoters, Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs, TrAP suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway, Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense, Determines pathogenicity (By similarity)

Belongs to the geminiviridae transcriptional activator protein family


This is mRNA export factor protein, from HHV-1, contains 511 amino acids, has 1 CHC2-type Zinc finger.

Multifunctional regulator of the expression of viral genes that contributes to the shutoff of host protein synthesis and mediates nuclear export of viral intronless mRNAs, Early in infection, this immediate early (EI) protein mediates the inhibition of cellular splicing, This results in the accumulation of unprocessed 3'end pre-mRNAs which can't be exported from the nucleus, Cellular protein synthesis is thereby shut off early after virus infection, Later in the infection, it helps recruit cellular RNA polymerase II to viral replication sites and promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP, ICP27 binds to NUP62 which may provide facilitated viral mRNA export and may compete with some host cell transport receptors for binding and inhibit cellular nucleocytoplasmic transport pathways, Also stimulates translation of viral transcripts, Repression of host gene expression blocks the cell cycle at the G1 phase and prevents apoptosis, Seems to silence the 3' splice site of the promyelocytic leukemia (PML) intron 7a, thereby switching PML isoforms from PML-II to PML-V, This could be linked to the accelerated mRNA export induced by ICP27 which might not provide sufficient time for PML pre-mRNA to be spliced in the nucleus (By similarity)

Belongs to the HHV-1 ICP27 protein family


This is Cellular nucleic acid-binding protein homolog protein, from Fission yeast, contains 179 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Acts in the sexual differentiation pathway, Is required for efficient conjugation, Double-stranded DNA-binding protein

To human CNBP and to retroviral nucleic acid binding proteins (NBP)


This is Protein E6 protein, from Human papillomavirus 3, contains 152 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation, In turn, apoptosis induced by DNA damage is inhibited, E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response

Belongs to the papillomaviridae E6 protein family


This is Protein E6 protein, from Human papillomavirus 7, contains 154 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 9, contains 148 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Protein E6 protein, from Human papillomavirus type 10, contains 148 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 12, contains 157 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 15, contains 141 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 17, contains 141 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 19, contains 166 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus type 26, contains 150 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT), The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis, E6 also inhibits immune response by interacting with host IRF3 and TYK2, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway


This is Protein E6 protein, from Human papillomavirus 27, contains 159 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 30, contains 153 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus type 32, contains 142 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus type 34, contains 148 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 40, contains 154 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus type 49, contains 138 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 52, contains 148 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus type 53, contains 154 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 7, contains 111 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)

Belongs to the papillomaviridae E7 protein family


This is Protein E7 protein, from Human papillomavirus 9, contains 93 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 10, contains 86 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 12, contains 103 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 15, contains 93 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 17, contains 95 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 19, contains 102 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 25, contains 102 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 26, contains 104 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 27, contains 92 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 30, contains 105 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 32, contains 104 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 34, contains 97 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 40, contains 111 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 49, contains 103 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 52, contains 99 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 53, contains 105 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 56, contains 105 amino acids, has 1  Zinc finger.


This is Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein protein, from Caenorhabditis briggsae, contains 163 amino acids, has 1 C4-type Zinc finger.

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein protein, from Caenorhabditis elegans, contains 163 amino acids, has 1 C4-type Zinc finger.


This is Peroxisome proliferator-activated receptor alpha protein, from African clawed frog, contains 474 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Key regulator of lipid metabolism, Activated by lipids, Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids, Once activated by a ligand, the receptor binds to promoter elements of target genes, Regulates the peroxisomal beta-oxidation pathway of fatty acids (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Myelin protein P0 protein, from Chicken, contains 249 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system, It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction


This is Transcriptional activator protein protein, from TYLCSV, contains 135 amino acids, has 1  Zinc finger.


This is Small ribosomal subunit protein eS27 protein, from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM), contains 84 amino acids, has 1 C4-type Zinc finger.

Component of the small ribosomal subunit, The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, Required for proper rRNA processing and maturation of 18S rRNAs

Belongs to the eukaryotic ribosomal protein eS27 family


This is Adult enhancer factor 1 protein, from Fruit fly, contains 308 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional repressor that binds specifically to fat body-specific enhancers, namely the adult ADH enhancer (AAE) and the enhancer that controls yolk protein gene expression


This is Chaperone protein DnaJ 1 protein, from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145), contains 399 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Transcriptional activator protein rec16 protein, from Fission yeast, contains 472 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional activator that controls the onset of premeiotic DNA synthesis by regulating res2 and some other factor(s) in a mei2 independent cascade


This is ADP-ribosylation factor GTPase-activating protein effector protein 2 protein, from Baker's yeast, contains 298 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for the ADP ribosylation factor family


This is Carbamoyltransferase HypF protein, from Azotobacter vinelandii, contains 776 amino acids, has 2 C4-type Zinc finger.

Involved in the maturation of [NiFe] hydrogenases, Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases, HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide

Belongs to the carbamoyltransferase HypF family


This is Protein cps3 protein, from Fission yeast, contains 583 amino acids, has 2 C3H1-type Zinc finger.

Responsible for supersensitivity to the spindle poison, isopropyl N-3-chlorophenyl carbamate, Has a role in meiosis


This is Transcriptional activator VP30 protein, from MARV, contains 281 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation, This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity)


This is E3 ubiquitin-protein ligase IAP-3 protein, from OpMNPV, contains 268 amino acids, has 1 RING-type Zinc finger.

RING-type

RING-finger E3 ubiquitin ligase required to prevent cellular apoptosis in infected cells, Ubiquitinates and subsequently targets host pro-apoptotic cellular proteins such as HID for degradation by the proteasome


This is T-cell surface glycoprotein CD8 alpha chain protein, from Cat, contains 239 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex, The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs), This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells, In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells, CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells


This is Immediate-early protein IE-0 protein, from AcMNPV, contains 261 amino acids, has 1 RING-type Zinc finger.

RING-type

Putative viral E3 ligase that plays an essential regulatory role in both viral DNA replication and transcriptional transactivation, The role in transcription has been shown to include activation of gene expression from early viral promoters, Promotes also the efficient egress of nucleocapsids from the host nucleus, May act as an E3 ligase that promotes ubiquitination of nucleocapsids proteins by vUbi and subsequent viral egress for the host nucleus


This is Brevican core protein protein, from Cat, contains 417 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a role in the terminally differentiating and the adult nervous system during postnatal development, Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

Secreted, extracellular space, extracellular matrix

Belongs to the aggrecan/versican proteoglycan family


This is Protein odd-skipped-related 1 protein, from Caenorhabditis elegans, contains 242 amino acids, has 3 C2H2-type Zinc finger.

May function as transcription regulator (Probable), Essential for larval development (PubMed:14648222, Ref,3), Required for morphogenesis and function of the digestive tract (PubMed:14648222)

Belongs to the Odd C2H2-type zinc-finger protein family


This is T-cell-specific surface glycoprotein CD28 protein, from Rabbit, contains 221 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival, Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation


This is T-lymphocyte activation antigen CD80 protein, from Rabbit, contains 299 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Involved in the costimulatory signal essential for T lymphocytes activation, T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor


This is T-lymphocyte activation antigen CD86 protein, from Rabbit, contains 330 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4, May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation, Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced, Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity)


This is Cytotoxic T-lymphocyte protein 4 protein, from Rabbit, contains 223 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor acting as a major negative regulator of T-cell responses, The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28


This is Chaperone protein DnaJ protein, from Coxiella burnetii (strain RSA 493 / Nine Mile phase I), contains 374 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is DnaJ protein homolog 2 protein, from Leek, contains 418 amino acids, has 1 CR-type Zinc finger.

CR-type

Plays a continuous role in plant development probably in the structural organization of compartments


This is DnaJ protein homolog ANJ1 protein, from Old man saltbush, contains 417 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Transcription factor GATA-4 protein, from Chicken, contains 380 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator, Binds to the consensus sequence 5'-AGATAG-3' (By similarity)


This is Transcription factor GATA-6 protein, from Chicken, contains 387 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type


This is GATA-binding factor 5-A protein, from African clawed frog, contains 390 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type


This is GATA-binding factor 5-B protein, from African clawed frog, contains 388 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type


This is Chaperone protein DnaJ protein, from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), contains 382 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), contains 296 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is UvrABC system protein A protein, from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), contains 943 amino acids, has 2 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate

Belongs to the ABC transporter superfamily, UvrA family


This is Primosomal protein N' protein, from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), contains 730 amino acids, has 2 C4-type Zinc finger.

Involved in the restart of stalled replication forks, Recognizes and binds the arrested nascent DNA chain at stalled replication forks, It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA

Belongs to the helicase family, PriA subfamily


This is DNA repair protein RadA protein, from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), contains 458 amino acids, has 1 C4-type Zinc finger.

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks, Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster, Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB, Does not have RecA's homology-searching function

Belongs to the RecA family, RadA subfamily


This is Chaperone protein DnaJ protein, from Staphylococcus aureus, contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Zinc finger transcription factor family protein 17 protein, from Caenorhabditis elegans, contains 705 amino acids, has 2 C2H2-type Zinc finger.

Probable transcription factor (PubMed:24885717), Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717)


This is Homeobox protein HOX1A protein, from Maize, contains 719 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Interacts with the shrunken (SHR) 26 bp feedback control element

Belongs to the PHD-associated homeobox family


This is Interleukin-12 subunit beta protein, from Sooty mangabey, contains 328 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity, IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues, IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines, IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity)


This is Programmed cell death protein 2 protein, from Mouse, contains 343 amino acids, has 1 MYND-type; atypical Zinc finger.

MYND-type; atypical

May be a DNA-binding protein with a regulatory function, May play an important role in cell death and/or in regulation of cell proliferation


This is Protein HIT1 protein, from Baker's yeast, contains 164 amino acids, has 1 HIT-type; degenerate Zinc finger.

HIT-type; degenerate


This is Chaperone protein DnaJ protein, from Mycoplasmoides genitalium, contains 389 amino acids, has 1 CR-type Zinc finger.

CR-type


This is DNA primase protein, from Mycoplasmoides genitalium, contains 607 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is UvrABC system protein A protein, from Mycoplasmoides genitalium, contains 952 amino acids, has 2 C4-type Zinc finger.


This is DNA primase protein, from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e), contains 626 amino acids, has 1 CHC2-type Zinc finger.


This is Small ribosomal subunit protein eS27 protein, from African clawed frog, contains 84 amino acids, has 1 C4-type Zinc finger.

Component of the small ribosomal subunit, The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, Required for proper rRNA processing and maturation of 18S rRNAs, Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome


This is mRNA decay factor CTH1 protein, from Baker's yeast, contains 325 amino acids, has 2 C3H1-type Zinc finger.

Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation, In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways, Negatively regulates primarily iron-dependent mitochondrial processes including respiration and amino acid biosynthesis


This is Chaperone protein DnaJ protein, from Francisella tularensis, contains 371 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Haemophilus ducreyi (strain 35000HP / ATCC 700724), contains 377 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Transcription initiation factor IIB protein, from Soybean, contains 313 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II


This is Transcription elongation factor S-II protein, from Fission yeast, contains 293 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity)


This is Protein ultraspiracle homolog protein, from Silk moth, contains 462 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Probable nuclear hormone receptor HR3 protein, from Greater wax moth, contains 557 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Putative receptor whose ligand is not yet known


This is Probable nuclear hormone receptor HR38 protein, from Silk moth, contains 360 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is Ecdysone receptor protein, from Midge, contains 536 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone, Binds to ecdysone response elements (ECRES)


This is Chaperone protein DnaJ protein, from Agrobacterium tumefaciens (strain C58), contains 377 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Chaperone protein DnaJ protein, from Legionella pneumophila, contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type


This is DNA primase protein, from Myxococcus xanthus, contains 606 amino acids, has 1 CHC2-type Zinc finger.


This is Protein E6 protein, from Human papillomavirus 22, contains 165 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Protein E6 protein, from Human papillomavirus 23, contains 157 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 24, contains 140 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 20, contains 102 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)


This is Protein E7 protein, from Human papillomavirus 21, contains 101 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 22, contains 100 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 23, contains 97 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 24, contains 96 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 28, contains 87 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 29, contains 90 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 70, contains 109 amino acids, has 1  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 28, contains 146 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation, In turn, apoptosis induced by DNA damage is inhibited, E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Protein E6 protein, from Human papillomavirus 29, contains 148 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus type 70, contains 158 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT), The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis, E6 also inhibits immune response by interacting with host IRF3 and TYK2, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway


This is Protein E6 protein, from Human papillomavirus 36, contains 157 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 36, contains 102 amino acids, has 1  Zinc finger.


This is Regulatory protein MIG1 protein, from Yeast, contains 474 amino acids, has 2 C2H2-type Zinc finger.

Involved in glucose repression of glucose metabolism genes

Belongs to the creA/MIG C2H2-type zinc-finger protein family


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Red seaweed, contains 288 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Zinc finger protein 84 protein, from Human, contains 738 amino acids, has 19 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein 157 protein, from Human, contains 506 amino acids, has 12 C2H2-type Zinc finger.


This is Protein E7 protein, from CRPV, contains 94 amino acids, has 1  Zinc finger.


This is CDK-activating kinase assembly factor MAT1 protein, from Spiny starfish, contains 324 amino acids, has 1 RING-type Zinc finger.

RING-type

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex


This is CDK-activating kinase assembly factor MAT1 protein, from African clawed frog, contains 309 amino acids, has 1 RING-type Zinc finger.

RING-type


This is UvrABC system protein A protein, from Pseudomonas lemoignei, contains 689 amino acids, has 1 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)


This is Transcription factor BCFI protein, from Silk moth, contains 508 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Regulates the expression of chorion genes through binding to gene promoter elements identical to those recognized by the GATA family of transcription factors, Isoform 1 may act as a gonad-specific trans-activator while isoform 2 and isoform 3 may serve as ubiquitous transcriptional modulators


This is Regulatory protein MIG1 protein, from Yeast, contains 543 amino acids, has 2 C2H2-type Zinc finger.


This is DNA primase protein, from Enterococcus faecalis (strain ATCC 700802 / V583), contains 628 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is mRNA export factor ICP27 homolog protein, from HHV-6 variant B, contains 516 amino acids, has 1 CHC2-type Zinc finger.

Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs

Belongs to the HHV-1 ICP27 protein family


This is Putative transcription elongation factor S-II protein, from Caenorhabditis elegans, contains 308 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type


This is Zinc finger protein 132 protein, from Human, contains 706 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 17 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Putative zinc finger protein 137 protein, from Human, contains 207 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 3; degenerate


This is DNA repair protein RAD14 protein, from Yeast, contains 396 amino acids, has 1  Zinc finger.


This is Sodium channel subunit beta-1 protein, from Rabbit, contains 218 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle, Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation, Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A

Belongs to the sodium channel auxiliary subunit SCN1B (TC 8,A,17) family


This is Large ribosomal subunit protein eL43 protein, from Methanococcus jannaschii, contains 92 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL43 family, Putative zinc-binding subfamily


This is Large ribosomal subunit protein eL24 protein, from Methanococcus jannaschii, contains 70 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL24 family


This is Protein E6 protein, from Human papillomavirus 68, contains 158 amino acids, has 2  Zinc finger.

Belongs to the papillomaviridae E6 protein family


This is Protein E7 protein, from Human papillomavirus 68, contains 110 amino acids, has 1  Zinc finger.

Belongs to the papillomaviridae E7 protein family


This is Protein ultraspiracle homolog protein, from Tobacco hawkmoth, contains 461 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone, May be an important modulator of insect metamorphosis (By similarity)


This is Formamidopyrimidine-DNA glycosylase protein, from Streptococcus mutans serotype c (strain ATCC 700610 / UA159), contains 273 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is Hyaluronan and proteoglycan link protein 1 protein, from Bovine, contains 354 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix


This is Small ribosomal subunit protein eS27 protein, from American lobster, contains 84 amino acids, has 1 C4-type Zinc finger.

Component of the small ribosomal subunit, The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, Required for proper rRNA processing and maturation of 18S rRNAs

Belongs to the eukaryotic ribosomal protein eS27 family


This is Zinc finger protein GLI2 protein, from Chicken, contains 663 amino acids, has 5 C2H2-type Zinc finger.

Functions as transcription regulator in the hedgehog (Hh) pathway, Functions as transcriptional activator, May also function as transcriptional repressor, Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity), Is involved in the smoothened (SHH) signaling pathway, Required for normal skeleton development (By similarity)

Belongs to the GLI C2H2-type zinc-finger protein family


This is DNA primase protein, from Campylobacter pylori, contains 559 amino acids, has 1 CHC2-type Zinc finger.


This is DNA repair protein RadA protein, from Campylobacter pylori, contains 448 amino acids, has 1 C4-type Zinc finger.

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks, Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster, Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB, Does not have RecA's homology-searching function


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Green alga, contains 411 amino acids, has 1 C4-type Zinc finger.


This is UvrABC system protein A protein, from Campylobacter pylori, contains 935 amino acids, has 2 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate


This is Myc-associated zinc finger protein protein, from Golden hamster, contains 331 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional regulator (By similarity), Acts as a transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide (PubMed:1454839)


This is UvrABC system protein A protein, from Ensifer meliloti, contains 973 amino acids, has 1 C4-type Zinc finger.


This is Formamidopyrimidine-DNA glycosylase protein, from Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491), contains 275 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Antitermination protein Q protein, from Bacteriophage P22, contains 207 amino acids, has 1  Zinc finger.

Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes, Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP, To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation, Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes

Belongs to the phage antitermination Q type 2 family


This is DNA primase protein, from Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491), contains 590 amino acids, has 1 CHC2-type Zinc finger.


This is DNA primase protein, from Neisseria meningitidis serogroup B (strain MC58), contains 590 amino acids, has 1 CHC2-type Zinc finger.


This is DNA primase protein, from Acyrthosiphon pisum symbiotic bacterium, contains 577 amino acids, has 1 CHC2-type Zinc finger.


This is Primosomal protein N' protein, from Acyrthosiphon pisum symbiotic bacterium, contains 726 amino acids, has 2 C4-type Zinc finger.

Involved in the restart of stalled replication forks, Recognizes and binds the arrested nascent DNA chain at stalled replication forks, It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA


This is Formamidopyrimidine-DNA glycosylase protein, from Pasteurella multocida (strain Pm70), contains 270 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is UvrABC system protein A protein, from Pasteurella multocida (strain Pm70), contains 943 amino acids, has 2 C4-type Zinc finger.

Belongs to the ABC transporter superfamily, UvrA family


This is Transcription initiation factor IIB 2 protein, from Sulfolobus solfataricus, contains 293 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

Stabilizes TBP binding to an archaeal box-A promoter, Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB)