This is Zinc finger BED domain-containing protein 6 protein, from Mouse, contains 980 amino acids, has 2 BED-type Zinc finger.

BED-type

BED-type

Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (PubMed:20016685, PubMed:20134481, PubMed:24043816, PubMed:29440408, PubMed:32557799), Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (PubMed:20016685, PubMed:20134481, PubMed:24043816, PubMed:29440408, PubMed:32557799), Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (PubMed:20016685, PubMed:29440408, PubMed:32557799), Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (PubMed:32557799), Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (PubMed:20016685, PubMed:32557799), Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816), Binds to the CDH2 gene and may directly repress CDH2 transcription (PubMed:26750727), Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (PubMed:26750727), May also play a role in embryonic beta cell differentiation (PubMed:24043816), May play a role in insulin sensitivity and glucose clearance (PubMed:29440408)


This is Ubiquitin carboxyl-terminal hydrolase 44 protein, from Giant panda, contains 711 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset, Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C), Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C, Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint, Promotes also the deubiquitination of histone H2A and H2B, Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (By similarity), Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (By similarity), Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability, Plays also a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (By similarity)

Belongs to the peptidase C19 family, USP44 subfamily


This is Speckle targeted PIP5K1A-regulated poly(A) polymerase protein, from Giant panda, contains 869 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs, Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1, In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs, In addition to adenylyltransferase activity, also has uridylyltransferase activity, However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase, Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA, Not involved in replication-dependent histone mRNA degradation

Belongs to the DNA polymerase type-B-like family


This is E3 ubiquitin-protein ligase RFWD3 protein, from Giant panda, contains 773 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage, Plays a key role in RPA-mediated DNA damage signaling and repair, Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination, Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint, May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome, In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53


This is E3 ubiquitin-protein ligase RNF217 protein, from Mouse, contains 515 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis

Belongs to the RBR family, RNF217 subfamily


This is E3 ubiquitin-protein ligase CCNB1IP1 protein, from Mouse, contains 276 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites, Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites, Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over, Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase, Overexpression causes delayed entry into mitosis


This is E3 ubiquitin-protein ligase MYLIP protein, from Rat, contains 445 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8, Activity depends on E2 enzymes of the UBE2D family, Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth, Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR


This is Diacylglycerol kinase theta protein, from Rat, contains 937 amino acids, has 3 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15337525), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15337525), Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity), Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (PubMed:15337525), Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (By similarity)

Belongs to the eukaryotic diacylglycerol kinase family


This is Tripartite motif-containing protein 2 protein, from Rat, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11, Plays a neuroprotective function, May play a role in neuronal rapid ischemic tolerance, Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity


This is Neutrophil immunoglobulin-like receptor 1 protein, from Rat, contains 547 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is E3 ubiquitin-protein ligase TRIM71 protein, from Rat, contains 855 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (By similarity), Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity), In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (By similarity), Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression, Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity), Specific regulator of miRNA biogenesis, Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity)


This is DNA-dependent metalloprotease SPRTN protein, from Rat, contains 496 amino acids, has 1 UBZ4-type Zinc finger.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity, DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde, Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis, Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity), Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs, SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity), Involved in recruitment of VCP/p97 to sites of DNA damage, Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation, Does not activate CHEK1 in response to DNA damage, May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA, Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity)


This is Lethal(3)malignant brain tumor-like protein 1 protein, from Rat, contains 826 amino acids, has 1 CCHHC-type Zinc finger.

CCHHC-type

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications, PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription, Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes, Also recognizes and binds RB1/RB monomethylated at 'Lys-860', Participates in the ETV6-mediated repression, Probably plays a role in cell proliferation, Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity)


This is E3 ubiquitin-protein ligase parkin protein, from Body louse, contains 461 amino acids, has 1 RING-type 0; atypical Zinc finger, has 1 RING-type Zinc finger, has 2 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type 0; atypical

RING-type

IBR-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as Marf, Opa1, Sep1, Tom20 and porin (By similarity), Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates, depending on the context (PubMed:26161729), Protects against mitochondrial dysfunction during cellular stress, by acting downstream of Pink1, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (By similarity), Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (By similarity), Appears to be particularly important in maintaining the physiology and function of cells with high energy demands that are undergoing stress or altered metabolic environment, including spermatids, muscle cells and neurons such as the dopaminergic (DA) neurons (By similarity), Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires Pink1-mediated phosphorylation of both park and ubiquitin (By similarity), In depolarized mitochondria, mediates the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of porin/VDAC; polyubiquitination of porin promotes mitophagy, while monoubiquitination of porin decreases mitochondrial calcium influx which ultimately inhibits apoptosis (By similarity), When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins (By similarity), Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy (By similarity), In developing tissues, inhibits JNK-mediated apoptosis by negatively regulating bsk transcription (By similarity), The Pink1-park pathway also promotes fission and/or inhibits fusion of damaged mitochondria by mediating the ubiquitination and subsequent degradation of proteins involved in mitochondrial fusion/fission such as Marf and Opa1 (By similarity), This prevents the refusion of unhealthy mitochondria with the healthy mitochondrial network and/or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (By similarity), Regulates motility of damaged mitochondria by phosphorylating Miro which likely promotes its park-dependent degradation by the proteasome; in motor neurons, this inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria being eliminated in the soma (By similarity), The Pink1-park pathway is also involved in mitochondrial regeneration processes such as promoting mitochondrial biogenesis, activating localized mitochondrial repair, promoting selective turnover of mitochondrial proteins and initiating the mitochondrial import of endogenous proteins (By similarity), Involved in mitochondrial biogenesis via the ubiquitination of transcriptional repressor Paris which leads to its subsequent proteasomal degradation and allows activation of the transcription factor srl (By similarity), Promotes localized mitochondrial repair by activating the translation of specific nuclear-encoded mitochondrial RNAs (nc-mtRNAs) on the mitochondrial surface, including several key electron transport chain component nc-mtRNAs (By similarity)

Belongs to the RBR family, Parkin subfamily


This is Mitochondrial cardiolipin hydrolase protein, from Bovine, contains 220 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical

Presents phospholipase and nuclease activities, depending on the different physiological conditions, Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity, Plays a key role in mitochondrial fusion and fission via its phospholipase activity, In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid, Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission, Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology, Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis (By similarity), Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation, Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation, The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis, Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA), MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins, Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts, piRNAs provide essential protection against the activity of mobile genetic elements, piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation, PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs, Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner (By similarity)

Belongs to the phospholipase D family, MitoPLD/Zucchini subfamily


This is E3 ubiquitin-protein ligase TRIM71 protein, from Bovine, contains 868 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type


This is Ubiquitin carboxyl-terminal hydrolase 13 protein, from Bovine, contains 863 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD), Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes, Also deubiquitinates USP10, an essential regulator of p53/TP53 stability, In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13, Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD), Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex, Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination, Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains, In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly, Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data


This is Ubiquitin carboxyl-terminal hydrolase 13 protein, from Chicken, contains 862 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD)


This is Mitochondrial cardiolipin hydrolase protein, from Dog, contains 254 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical


This is BRAP2 RING ZnF UBP domain-containing protein 1 protein, from Mouse-ear cress, contains 488 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 UBP-type; degenerate Zinc finger.

RING-type; degenerate

UBP-type; degenerate

RING-type ubiquitin E3 ligase required for seed germination and post-germination growth


This is E3 ubiquitin-protein ligase UHRF1 protein, from Zebrafish, contains 776 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification, Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication, In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins, Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication, Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications, Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins, However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo (By similarity), Required for pregastrula and lens development


This is Vacuolar protein sorting-associated protein 41 homolog protein, from Zebrafish, contains 854 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways, Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes


This is E3 ubiquitin-protein ligase TRIM71 protein, from Zebrafish, contains 824 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance, Binds to miRNAs and participates in post-transcriptional repression of transcripts, Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development


This is Zinc finger protein 568 protein, from Mouse, contains 671 amino acids, has 11 C2H2-type Zinc finger.

Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112), Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536), Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155), May enhance proliferation or maintenance of neural stem cells (PubMed:23071813)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is PR domain zinc finger protein 13 protein, from Mouse, contains 754 amino acids, has 4 C2H2-type Zinc finger.

May be involved in transcriptional regulation, Is required for the differentiation of Kiss1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus, Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development (PubMed:34730112)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is PR domain zinc finger protein 14 protein, from Mouse, contains 561 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 5 C2H2-type Zinc finger.

C2H2-type 1; atypical

Transcription factor that has both positive and negative roles on transcription (By similarity), Plays a role in cellular pluripotency, Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression, Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation


This is WD repeat and FYVE domain-containing protein 1 protein, from Mouse, contains 410 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1, Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436)


This is Zinc finger protein 296 protein, from Mouse, contains 445 amino acids, has 6 C2H2-type Zinc finger.

May be a transcriptional corepressor with KLF4


This is E3 ubiquitin-protein ligase RNF169 protein, from Mouse, contains 694 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage, Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization, Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1, E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair


This is Sperm acrosome membrane-associated protein 6 protein, from Mouse, contains 339 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Sperm protein required for fusion of sperm with the egg membrane during fertilization

Cytoplasmic vesicle, secretory vesicle, acrosome membrane


This is Carcinoembryonic antigen-related cell adhesion molecule 16 protein, from Mouse, contains 426 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane

Belongs to the immunoglobulin superfamily, CEA family


This is Zinc finger protein 431 protein, from Mouse, contains 526 amino acids, has 15 C2H2-type Zinc finger.

Sequence-specific DNA binding transcriptional repressor, Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases, Acts as a specific transcriptional repressor for PTCH1 during embryonic development, Required for osteoblast differentiation and sonic hedgehog/SHH signaling response, Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1


This is E3 ubiquitin-protein ligase ARK2C protein, from Mouse, contains 347 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation (PubMed:23610558), Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP (PubMed:23610558), Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL (PubMed:23610558)


This is Ubiquitin carboxyl-terminal hydrolase 45 protein, from Zebrafish, contains 803 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Catalyzes the deubiquitination of SPDL1 (By similarity), Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (By similarity), May be involved in the maintenance of photoreceptor function (PubMed:30573563), May play a role in normal retinal development (PubMed:27613029)


This is Protein kinase C iota type protein, from Rat, contains 596 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway, Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis, In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step, In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD, Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion, In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival, Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR, This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation, Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity, Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs), In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis, Downstream of PI3K is required for insulin-stimulated glucose transport, Activates RAB4A and promotes its association with KIF3A which is required for the insulin-induced SLC2A4/GLUT4 translocation in adipocytes, Is essential in early embryogenesis and development of differentiating photoreceptors by playing a role in the establishment of epithelial and neuronal polarity (By similarity), Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (PubMed:27498875)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Ubiquitin carboxyl-terminal hydrolase 13 protein, from Zebrafish, contains 860 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD)


This is Activity-dependent neuroprotective protein a protein, from Zebrafish, contains 969 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 5; atypical Zinc finger, has 1 C2H2-type 6; atypical Zinc finger, has 1 C2H2-type 8; atypical Zinc finger, has 1 C2H2-type 9; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 5; atypical

C2H2-type 6; atypical

C2H2-type 8; atypical

C2H2-type 9; atypical

May be involved in transcriptional regulation (PubMed:23071114, PubMed:32533114), Positively modulates wnt-beta-catenin/ctnnb1 signaling (PubMed:32533114), Required for embryonic neurogenesis (PubMed:32533114), Required for progression through late erythroid differentiation (PubMed:23071114)


This is Nuclear receptor ROR-alpha A protein, from Zebrafish, contains 468 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) (By similarity), Required for proper cerebellum development (PubMed:29656859)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is E3 SUMO-protein ligase PIAS4-A protein, from Zebrafish, contains 505 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase (By similarity), May play a role as a transcriptional coregulator in various cellular pathways (By similarity), Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity), Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (By similarity), Negatively regulates induction of interferon phi 1 (ifnphi1) mediated by mavs and ticam1/trif, Also inhibits ifnphi1-mediated activation of the interferon-stimulated genes (ISGs) pkz and cd40, and to a lesser extent rsad2 and isg15 (PubMed:22345667), May inhibit ticam1/trif-mediated activation of NF-kappa-B (PubMed:22345667)


This is Histone-lysine N-trimethyltransferase SMYD5 protein, from Zebrafish, contains 415 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity), Plays a crucial role in hematopoiesis during embryogenesis by negatively regulating expression of genes related to both primitive and definitive hematopoiesis (PubMed:27377701)


This is E3 ubiquitin-protein ligase CCNB1IP1 homolog protein, from Mouse-ear cress, contains 304 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Ubiquitin E3 ligase required for class I crossover (CO) formation during meiosis


This is E3 ubiquitin-protein ligase JMJ24 protein, from Mouse-ear cress, contains 944 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical

Binds histone H3 but seems to have lost demethylase activity probably due to its inability to bind iron Fe(2+) (PubMed:26979329), Possesses E3 ubiquitin ligase activity and targets directly CMT3 for proteasomal degradation to initiate destabilization of the heterochromatic state (e,g, CHG cytosine methylation and H3K9me2) of endogenous silenced loci (PubMed:26798133, PubMed:26979329), Required for the removal of repressive H3K9me2 histone marks to facilitate the transcription of AtSN1, AtMu1c, solo LTR and SDC, thus counteracting their transcriptional silencing (PubMed:26119694, PubMed:26979329), Mainly required to promote the basal level transcription of silenced loci such as TE and repeats targeted by RNA-dependent DNA methylation (RdDM) for silencing, a specialized branch of the RNA interference (RNAi) pathway (PubMed:26119694, PubMed:28400174, PubMed:26979329), Cooperates also with RNAi pathways for gene silencing both by contributing to the production of 24-nt siRNA to initiate RdDM and by recruiting RDR2 to enable local transcripts to make dsRNA (PubMed:26119694, PubMed:28400174), Antagonizes histone H3K9 demethylase IBM1/JMJ25 function (PubMed:28400174)

Belongs to the JARID1 histone demethylase family


This is BRCA1-associated RING domain protein 1 protein, from Mouse-ear cress, contains 714 amino acids, has 1 RING-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type Zinc finger.

RING-type

C2HC pre-PHD-type

PHD-type

Binds specifically to H3K4me3 regions of target genes (e,g, WUS and WOX5) promoters to repress their transcription via chromatin remodeling, Required for the shoot apical meristem (SAM) organization and maintenance, by confining WUS expression to the organizing center, and for the quiescent center (QC) development in the root apical meristem (RAM), by repressing WOX5 expression in the root proximal meristem (PubMed:18591352, PubMed:25631790), Plays a role in DNA repair and in cell-cycle control, Required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR) (PubMed:16957774)


This is Lysine-specific demethylase JMJ18 protein, from Mouse-ear cress, contains 819 amino acids, has 1 C5HC2 Zinc finger.

Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a specific activity for H3K4me3 and H3K4me2, No activity on H3K9me3/2, H3K27me3/2 and H3K36me3/2, Involved in the control of flowering time by demethylating H3K4me3 at the FLC locus and repressing its expression, The repression of FLC level and reduction in H3K4me3 at the FLC locus results in induction of the flowering activator FT, which is a downstream target of FLC


This is Probable BOI-related E3 ubiquitin-protein ligase 2 protein, from Mouse-ear cress, contains 358 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable E3 ubiquitin-protein ligase, Has no effect on the stability of the DELLA proteins


This is Vacuolar sorting protein 18 protein, from Mouse-ear cress, contains 988 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Essential protein required during embryogenesis, Believed to act as a core component of the putative HOPS endosomal tethering complex and of the class C core vacuole/endosome tethering (CORVET) complex, CORVET is required for vacuolar transport of SYP22, HOPS is required for the central vacuole formation, Involved in root development (PubMed:29463724), Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (By similarity)


This is Zinc finger protein SHOOT GRAVITROPISM 5 protein, from Mouse-ear cress, contains 445 amino acids, has 3 C2H2-type Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

CCHC-type 2; atypical

Transcription factor involved in inflorescence stems gravitropism, probably by regulating starch accumulation in amyloplasts of graviperceptive cells, Required for stem circumnutation movements, Regulates lateral organ morphogenesis and gravitropic responses (PubMed:24039602), Acts cooperatively with IDD16 to control silique and branche orientation (PubMed:24039602), Involved in the establishment of auxin gradients through the regulation of auxin biosynthesis and transport (PubMed:24039602)


This is E3 ubiquitin-protein ligase APD4 protein, from Mouse-ear cress, contains 399 amino acids, has 1 RING-type Zinc finger.

RING-type

Involved in pollen mitosis II (PMII) regulation during male gametogenesis


This is E3 ubiquitin-protein ligase RSL1 protein, from Mouse-ear cress, contains 398 amino acids, has 1 RING-type Zinc finger, has 1 RING-type 3; degenerate Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 4; degenerate Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

RING-type 3; degenerate

IBR-type

RING-type 4; degenerate

RING-type 2; atypical

Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (PubMed:24388521), Negative regulator of the abscisic acid (ABA) signaling pathway which targets PYL4 and PYR1 ABA receptors in plasma membrane to promote their FREE1/FYVE1-dependent trafficking and degradation upon ubiquitynation; this process involves clathrin-mediated endocytosis and trafficking through the ESCRT pathway (PubMed:25330042, PubMed:27495812), Involved in the maintenance of seed longevity (PubMed:24388521), May enhance gibberellins responses (PubMed:24388521)


This is Chromatin remodeling protein EBS protein, from Mouse-ear cress, contains 234 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Chromatin remodeling factor that binds to methylated histone (e,g, H3K4me2/3) to prevent their acetylation (e,g, H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulating the transcription of target genes (PubMed:25281686), Negative regulator in developmental processes in a gibberellic acid- (GA-) dependent manner, such as germination, flowering induction, and flower organ specification, probably by modulating developmental gene expression (PubMed:11340178, PubMed:25281686), Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering (PubMed:25281686), Negatively regulates the expression of the floral integrator FT epigenetically, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation at FT locus (PubMed:25281686, PubMed:12837946)


This is DNA-(apurinic or apyrimidinic site) endonuclease 2 protein, from Mouse-ear cress, contains 610 amino acids, has 1 GRF-type; atypical Zinc finger.

GRF-type; atypical

Exhibits apurinic/apyrimidinic (AP) endonuclease activity in vitro (PubMed:25569774), By contrast, another report show that APE2 has no biochemical activity (PubMed:25228464), Unable to catalyze the conversion of 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) to 3'-OH (PubMed:25228464, PubMed:25569774), Has no in vitro 3'-phosphatase activity (PubMed:25228464, PubMed:25569774), Redundant with APE1L and at least one functional allele is required for seed viability (PubMed:19172180), Has a strong non-specific affinity to DNA (PubMed:25228464)

Belongs to the DNA repair enzymes AP/exoA family


This is E3 ubiquitin ligase PARAQUAT TOLERANCE 3 protein, from Mouse-ear cress, contains 826 amino acids, has 1 CCHC-type Zinc finger, has 1 RING-type; degenerate Zinc finger.

CCHC-type

RING-type; degenerate

E3 ubiquitin ligase acting as a negative regulator of oxidative stress tolerance, probably by mediating 26S proteasome-mediated degradation of PRMT13/PRMT4B, thus preventing APX1 and GPX1 accumulation via the reduction of histone H3 methylation (H3R17me2a), Confers sensitivity to cadmium CdCl(2) and salt NaCl stresses


This is E4 SUMO-protein ligase PIAL2 protein, from Mouse-ear cress, contains 760 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

E4-type SUMO ligase that promotes SUMO chain formation in a SCE1-dependent manner and thus contributes to a pathway for proteolytic removal of sumoylation substrates, Involved in stress responses and sulfur metabolism

Belongs to the PIAL protein ligase family


This is DNA replication licensing factor MCM6 protein, from Mouse-ear cress, contains 831 amino acids, has 1 C4-type Zinc finger.

Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells


This is Lysine-specific demethylase JMJ13 protein, from Mouse-ear cress, contains 787 amino acids, has 1 C4HCHC Zinc finger, has 1 C5HC2 Zinc finger.

Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3 with a specific activity for H3K27me3 and involved in the regulation of gene expression (PubMed:30899015), Acts as a temperature and photoperiod dependent flowering repressor (PubMed:30899015)


This is Probable E3 SUMO-protein ligase RNF212 protein, from Mouse, contains 307 amino acids, has 1 RING-type Zinc finger.

RING-type

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes, Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11, May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites, Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination


This is E3 ubiquitin-protein ligase UHRF1 protein, from Western clawed frog, contains 775 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification, Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication, In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins, Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication, Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications, Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins, However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo


This is DNA-dependent metalloprotease SPRTN protein, from Western clawed frog, contains 436 amino acids, has 1 UBZ4-type Zinc finger.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (By similarity), DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde, Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis, Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4 (By similarity), Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs, SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity), May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis, Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage (By similarity)


This is MORC family CW-type zinc finger protein 3 protein, from Mouse, contains 942 amino acids, has 1 CW-type Zinc finger.

CW-type

Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response, Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function, Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504), Binds RNA in vitro, Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3, The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0


This is PAN2-PAN3 deadenylation complex subunit PAN3 protein, from Thermochaetoides thermophila, contains 640 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1

Belongs to the protein kinase superfamily, PAN3 family


This is Peroxisome assembly protein 10 protein, from Sporotrichum thermophile, contains 454 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is Peroxisome assembly protein 2 protein, from Sporotrichum thermophile, contains 591 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity), PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity)


This is E3 ubiquitin-protein ligase CBL-C protein, from Rat, contains 497 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome, Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3, Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR, Inhibits EGF stimulated MAPK1 activation, Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins, In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival


This is DNA-dependent metalloprotease SPRTN protein, from Mouse, contains 497 amino acids, has 1 UBZ4-type Zinc finger.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:28199696, PubMed:27871365), DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:28199696, PubMed:27871365), Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis, Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity), Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs, SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity), Involved in recruitment of VCP/p97 to sites of DNA damage, Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation, Does not activate CHEK1 in response to DNA damage, May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA, Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity)


This is Zinc finger E-box-binding homeobox protein zag-1 protein, from Caenorhabditis elegans, contains 596 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 5; degenerate

Transcription factor (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162), Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA (PubMed:12835394), Acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspects of terminal differentiation, including cell migration, axonal development and gene expression (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162), Promotes touch receptor neuron differentiation by repressing the expression of egl-44 and egl-46 (PubMed:30291162), As egl-44 and egl-46, probably acting as a heterodimer, repress expression of zag-1 in FLP neurons, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates (PubMed:30291162), Required for axon guidance (PubMed:12835395), Involved in the proper development of the pharynx (PubMed:12835395), Required for pharynx isthmus peristalsis, probably via a role in the differentiation of the M4 cholinergic motor neuron (PubMed:25474681), Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter (PubMed:12835394, PubMed:12835395), May also act as a transcriptional activator of the homeodomain ceh-28 (PubMed:25474681)


This is Hypoxia-inducible factor prolyl hydroxylase protein, from Caenorhabditis elegans, contains 723 amino acids, has 1 MYND-type; atypical Zinc finger.

MYND-type; atypical

Regulates the trafficking of the glutamate receptor glr-1, probably independently of hif-1, by regulating lin-10 subcellular localization in response to oxygen levels, May hydroxylate lin-10


This is CCCH-type zinc finger protein oma-1 protein, from Caenorhabditis elegans, contains 407 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos (PubMed:18854162, PubMed:18417623, PubMed:19786575, PubMed:20826530, PubMed:24014033), Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes (PubMed:25261697), Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development (PubMed:11702779, PubMed:12296824, PubMed:12781695, PubMed:16289132, PubMed:16611242, PubMed:19786575, PubMed:20826530, PubMed:25261697), Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif-1 to negatively regulate their translation (PubMed:19786575, PubMed:20826530), By suppressing the translation of the E3 ligase zif-1, may in turn play a role in the stabilization of zif-1 targets such as the maternal transcriptional repressor protein pie-1 (PubMed:16343905, PubMed:20826530), Following fertilization, sequesters the transcription initiation factor, taf-4, in the cytoplasm, which prevents its nuclear localization and thus allows for transcriptional suppression in early embryos, but not in oocytes (PubMed:18854162), Also, together with oma-2, is involved in P-granule distribution during embryonic development (PubMed:16611242)


This is Nuclear hormone receptor unc-55 protein, from Caenorhabditis elegans, contains 370 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Belongs to the nuclear hormone receptor family


This is High zinc activated nuclear receptor protein protein, from Caenorhabditis elegans, contains 413 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis, Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc, This in turn, allows for internal zinc levels to be detected and regulated


This is Myotubularin-related protein 6 protein, from Caenorhabditis elegans, contains 676 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May dephosphorylate phosphatidylinositol-3-phosphate (PI3P) (PubMed:12788949, PubMed:14565969), In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels (PubMed:14565969, PubMed:21076391), Regulates fluid phase endocytosis in coelomocytes (PubMed:14565969), Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14 (PubMed:21076391), By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20 (PubMed:21076391), Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast descendants and HSN neurons during larval development (PubMed:21076391), Involved in the formation of correct synapse number in DA9 motor neurons probably in part by regulating the secretion of Wnt ligand egl-20 (PubMed:25479419)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is Kinase suppressor of Ras B protein, from Caenorhabditis elegans, contains 550 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf (PubMed:23900546, PubMed:11882296), In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation (PubMed:11882296, PubMed:26510792), Plays a role in meiotic recombination events (PubMed:26510792), Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells (PubMed:11882296)

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family


This is Zinc finger protein GFI1 homolog pag-3 protein, from Caenorhabditis elegans, contains 336 amino acids, has 5 C2H2-type Zinc finger.

Transcription factor (PubMed:26096732), Plays a role in the determination of neuroblast cell fate and neuronal differentiation (PubMed:11923211, PubMed:26096732), Negatively modulates expression of several components of dense-core vesicles (DCVs), thereby, in a DCV membrane protein ida-1-dependent manner, regulating neurosecretion (PubMed:19343207), Negatively modulates the transcription of its own gene, the mechanosensory gene mec-3, and also other touch neuron-specific genes in the BDU neurons; required for coordinated movement (PubMed:9169852, PubMed:8770591, PubMed:26096732), Required to determine the identity of BDU sensory neurons in concert with transcription factor unc-86, regulating expression of a number of genes, including transcription factors ceh-14 and ahr-1, neuropeptides flp-10, nlp-1 and nlp-15, and tyramine receptor-encoding ser-2 (PubMed:26096732), Acts in concert with non-canonical WNT signaling to negatively modulate transcription of mec-3 gene in BDU neurons (PubMed:26096732), May act in concert with transcription factor unc-3 in motor neuron fate determination (PubMed:18817768), May play a role programmed cell death (PubMed:11923211)


This is Nuclear hormone receptor family member fax-1 protein, from Caenorhabditis elegans, contains 419 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor that binds DNA containing an extended core motif half-site sequence 5'-ANGTCA-3' (PubMed:10648229, PubMed:18179707), Required for locomotion, neuron axon pathfinding, and regulation of expression of some peptide neurotransmitter precursors and of NMDA glutamate receptor genes (PubMed:10648229, PubMed:16183052, PubMed:9216999, PubMed:22690911), Involved in specifying interneuron identity, in concert with paired-like homeodomain unc-42 (PubMed:16183052), Plays a role in recognition of the PVPR and PVQL axons by the AVKR and HSNL growth cones (PubMed:9216999)


This is Nuclear hormone receptor 114 protein, from Caenorhabditis elegans, contains 418 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Probable transcription factor which may have a role in detoxifying dietary metabolites arising from bacterial tryptophan metabolism (PubMed:23499532), Required for fertility and involved in proper postembryonic germline development, especially germline stem cell (GSC) proliferation (PubMed:23499532), Required for activation of the methionine/S-adenosylmethionine (Met/SAM) cycle in response to low levels of SAM (PubMed:33016879)


This is RNA-binding protein pos-1 protein, from Caenorhabditis elegans, contains 264 amino acids, has 2 C3H1-type Zinc finger.

RNA-binding protein that coordinates cell fate specification and differentiation during early embryogenesis (PubMed:9834181, PubMed:23034181), Binds to a consensus pos-1 recognition element (PRE) consisting of the sequence 5'-UA(U 2-3)RGD(N 1-3)G-3', where R is any purine, D is A, G, or U, and N is any base (PubMed:18952820, PubMed:23034181), The PRE motif is found within the 3' untranslated region of many maternal transcripts required for early development (PubMed:18952820), Binds to the 3' untranslated region (UTR) of Notch receptor homolog glp-1, thereby repressing glp-1 translation in the posterior blastomeres in the embryo (PubMed:12702662, PubMed:23034181), Binding to glp-1 3' UTR excludes cell fate regulator gld-1 binding to an overlapping binding site in the glp-1 3' UTR (PubMed:23034181), Binds to the neg-1 3'UTR thereby opposing neg-1 expression and cytoplasmic polyadenylation of the neg-1 mRNA poly(A) tail promoted by gld-2 and gld-3 (PubMed:26096734), By inhibiting the cytoplasmic lengthening of neg-1 mRNA, restricts the accumulation of neg-1 protein and promotes endo-mesoderm development in anterior blastomeres (PubMed:26096734), Essential for germline specification (PubMed:9834181)


This is Kinase suppressor of Ras A protein, from Caenorhabditis elegans, contains 771 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf, Involved in sex myoblast migration (PubMed:8521513, PubMed:11882296), Plays a role in responses to M,nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855), Functions redundantly with ksr-2 in the Ras-mediated regulation of larval survival, the development of excretory canal and in mpk-1 phosphorylation in somatic cells (PubMed:8521513, PubMed:11882296), In addition, involved in determining vulval precursor cell fate during vulval induction independently of its kinase activity (PubMed:8521514, PubMed:8521513, PubMed:10409742, PubMed:11882296), Plays a role in egg-laying (PubMed:23900546)


This is Spalt-like protein sem-4 protein, from Caenorhabditis elegans, contains 744 amino acids, has 7 C2H2-type Zinc finger.

Transcription factor, involved in positive and negative modulation of transcription (PubMed:12835398, PubMed:28614700), Binds to multiple DNA sequence motifs in the regulatory elements of target genes, including homeobox selector egl-5 and LIM homeobox mec-3 (PubMed:12835398), Involved in cell-fate regulation in multiple lineages, including neuronal, mesodermal and vulval (PubMed:8756352, PubMed:28614700, PubMed:12835398, PubMed:10926783), Required to regulate the fate of PLM touch receptor neurons, acting via negative modulation of transcription of egl-5 and mec-3 (PubMed:12835398), May modulate gene expression by interacting with different transcription factors during neuronal and mesodermal cell development (PubMed:8756352), Promotes the proliferative sex myoblast (SM) fate, in a cell autonomous manner, acting via the SoxC transcription factor sem-2 (PubMed:28614700), Involved in vulval cell-fate determination, acting by regulating expression of homeobox protein lin-39, and may link lin-39 to incoming signaling pathways (PubMed:10926783), Plays a role in detoxification of reactive oxygen species (ROS), by regulating expression of transcription factor skn-1 and the phase II detoxification genes (PubMed:32718932)

Belongs to the sal C2H2-type zinc-finger protein family


This is Nuclear hormone receptor family member daf-12 protein, from Caenorhabditis elegans, contains 753 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor which binds directly to response elements in target gene promoters (PubMed:9477318, PubMed:10859169, PubMed:15314028, PubMed:15489294, PubMed:15383841, PubMed:15611047, PubMed:16626392, PubMed:19828440, PubMed:21814518), Activity is modulated by binding of steroid hormone ligands that include dafachronic acids (PubMed:16529801), Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues (PubMed:9477318, PubMed:10859169, PubMed:15489294, PubMed:15383841, PubMed:16626392, PubMed:19828440, PubMed:21814518), Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1 (PubMed:19828440), Plays a role in controlling the timing of seam cell development during the larval stages (PubMed:21471153), Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs (PubMed:23990780), Controls expression of genes that promote the aerobic catabolism of fatty acids for reproductive growth (PubMed:25774872), May be involved in thermotolerance (PubMed:24957743)


This is Transcription factor egl-46 protein, from Caenorhabditis elegans, contains 286 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 2 C2H2-type Zinc finger.

C2H2-type 1; atypical

Transcription factor (PubMed:30291162), Represses expression of genes involved in differentiation of touch receptor neurons (TRN), probably acting as a heterodimer with egl-44, perhaps by occupying similar cis-regulatory elements as an unc-86/mec-3 heterodimer (PubMed:30291162), Plays a role in cell fate specification of neurons, including the hook neuron HOB, the gas-sensing neuron BAG and touch receptor neurons (PubMed:12954713, PubMed:25395666, PubMed:30291162), Plays a role in neuron differentiation by repressing the expression of zag-1 in FLP neurons, probably acting as a heterodimer with egl-44; because zag-1 represses expression of egl-46 and egl-44, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates (PubMed:30291162), Acts downstream of egl-44 to prevent touch cell differentiation in FLP neurons (PubMed:11274062), Involved in male mating behavior, acting in concert with egl-44, via modulation of expression of polycystins lov-1 and pkd-2, homeodomain protein ceh-26, and neuropeptide-like protein nlp-8 (PubMed:12954713), Modulates the expression of a subset of terminal differentiation genes involved in O(2)- and CO(2)-sensing, acting in parallel to ets-5 and egl-13 (PubMed:25395666), May act upstream of RFX transcription factor daf-19 to regulate gene expression specifically in the HOB neuron (PubMed:20923979), Plays a role in specifying commissural dendrites of the PVD nociceptive neurons, acting in concert with egl-44 (PubMed:29031632), In association with egl-44, regulates cell cycle exit in the neuronal Q cell lineage (PubMed:23946438)


This is Zinc finger transcription factor pqm-1 protein, from Caenorhabditis elegans, contains 295 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Zinc finger transcription factor which acts as both a transcriptional activator and repressor (PubMed:23911329, PubMed:30956009), Binds to the promoters of genes that contain the 5'-CTTATCA-3' DNA consensus sequence in their regulatory region (PubMed:23911329, PubMed:31532389), Functions downstream of the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:23911329, PubMed:27401555), Involved in normal development, lifespan, stress response, lipid metabolism, innate immunity and exit from the developmentally arrested larval state known as dauer (PubMed:23911329, PubMed:27401555, PubMed:29949773, PubMed:31532389, PubMed:33009389), Required for stress-induced expression of hsp-90 and resistance to heat stress, perhaps as part of a systemic stress signaling pathway (PubMed:29949773), Involved in maintenance of proteostasis (PubMed:29949773), Under hypoxic stress increases lipid levels by positively regulating fatty acid synthesis via fat-7 expression (PubMed:33009389), Associates with homeobox protein ceh-60 at the promoters of some stress-responsive genes to regulate expression; may require phosphorylation for transcriptional repression activity (PubMed:30956009), Acts downstream of nhr-14 to activate transcription of intestinal metal transporter smf-3, modulating innate immunity and iron uptake (PubMed:31532389), May act downstream of the mTORC2 signaling mediated pathway (PubMed:27401555), May act in a mutually exclusive manner with the FOXO transcription factor daf-16 (PubMed:23911329, PubMed:27401555)


This is Set1/Ash2 histone methyltransferase complex subunit ash-2 protein, from Caenorhabditis elegans, contains 570 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable), Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation (PubMed:21527717, PubMed:20555324), Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258), Functions as transcriptional regulator (PubMed:28379943), Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:20555324, PubMed:22012258, PubMed:28379943)


This is Zinc finger transcription factor lin-29 protein, from Caenorhabditis elegans, contains 459 amino acids, has 5 C2H2-type Zinc finger.


This is Putative transcription factor egl-18 protein, from Caenorhabditis elegans, contains 376 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Probable transcription factor (PubMed:11532911, PubMed:24885717), Involved in embryonic development and in vulval development in larvae, acting redundantly, at least in part, with elt-6 (PubMed:11532911, PubMed:14975731, PubMed:12399309, PubMed:24885717), Perhaps acting together with elt-6, may form a positive feedback loop to initiate and maintain lin-39 gene expression to ensure proper vulval precursor cell (VPC) fate specification (PubMed:24885717), Together with elt-6, acts as a downstream target of the Wnt/beta-catenin asymmetry pathway, required to adopt or maintain the seam cell fate (PubMed:23633508), Required in seam cells, acting redundantly with elt-6, to promote production of alae, expression of several seam-specific genes and maintenance of seam cells in an unfused state (PubMed:11532911, PubMed:23633508), Plays a role in longevity (PubMed:18662544), May form a transcriptional circuit with GATA factors elt-3 and elt-6 (PubMed:18662544)


This is Tyrosine-protein kinase receptor cam-1 protein, from Caenorhabditis elegans, contains 928 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Involved in the positioning of the nerve ring

Belongs to the protein kinase superfamily, Tyr protein kinase family, ROR subfamily


This is Zinc finger protein ham-2 protein, from Caenorhabditis elegans, contains 392 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Probable transcription factor that acts downstream of egl-15, to promote migration of the HSN motor neurons from the tail to the gonad primordium during HSN cell differentiation (PubMed:10049362)


This is Nuclear hormone receptor family member nhr-66 protein, from Caenorhabditis elegans, contains 733 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor (PubMed:33259792), Binds to regulatory elements and regulates transcription of target genes, including the potassium channel accessory subunit mps-2 (PubMed:33259792), Negatively regulates transcription of mps-2, thereby modulating age-dependent memory decline (PubMed:33259792), In concert with nuclear hormone receptor nhr-49, involved in regulating target genes with roles in sphingolipid breakdown and lipid remodeling (PubMed:22511885), Plays a role in modulating mitochondrial morphology and function (PubMed:22511885)


This is Nuclear protein localization protein 4 homolog 1 protein, from Caenorhabditis elegans, contains 529 amino acids, has 1 RanBP2-type Zinc finger.

In association with ufd-1 and ATPase cdc-48,1 and/or cdc-48,2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:22768338), This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:22768338), During S phase and in association with ufd-1, cdc-48,1 and/or cdc-48,2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371), Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564)


This is Zinc finger protein ztf-16 protein, from Caenorhabditis elegans, contains 480 amino acids, has 8 C2H2-type Zinc finger.

Positively regulates the expression of ver-1 in the amphid sheath glia of amphid sensory neurons (PubMed:22298710), Together with ehn-3, plays a role in somatic gonad development and is required for proper gonadal primordium assembly and somatic gonad precursor cell morphology (PubMed:20026024)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase CCNB1IP1 homolog protein, from Rice, contains 303 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Ubiquitin E3 ligase required for class I crossover (CO) formation during meiosis


This is Tissue-resident T-cell transcription regulator protein ZNF683 protein, from Mouse, contains 458 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:22885984, PubMed:27102484), Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T-cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:22885984, PubMed:27102484), Also plays a role in the differentiation of both thymic and peripheral NKT cells (PubMed:22885984), Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation (PubMed:22885984), Positively regulates granzyme B production in NKT cells after innate stimulation (PubMed:22885984), Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions (PubMed:27102484)


This is E3 ubiquitin-protein ligase TRIM34B protein, from Mouse, contains 485 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity), Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses, During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination, In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity), Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis, Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity), Regulates intestinal inflammation by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504)


This is E3 ubiquitin ligase Rnf157 protein, from Rat, contains 682 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (By similarity), Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (By similarity), May act as a scaffold molecule to regulate this process (By similarity), Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity)


This is E3 ubiquitin-protein ligase TRIM9 protein, from Fruit fly, contains 740 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type; degenerate

B box-type 1; atypical

B box-type

E3 ubiquitin-protein ligase activity (By similarity), During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra (PubMed:22084112, PubMed:21338947), Regulates fine-scale topography of C4da axon terminals upon neuronal activity (PubMed:24746793), During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra (PubMed:27743477)


This is E3 ubiquitin-protein ligase Hakai protein, from Fruit fly, contains 473 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required during early development (PubMed:19682089), E3 ubiquitin-protein ligases mediate ubiquitination of target proteins (PubMed:19682089), Required for epithelial integrity and midgut morphogenesis (PubMed:19682089), Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189), Its function in the WMM complex is unknown (PubMed:29535189)


This is E3 ubiquitin-protein ligase RNF103 protein, from Human, contains 685 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway


This is Signal-regulatory protein beta-1 protein, from Human, contains 398 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Ig-like C1-type

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes, Participates also in the recruitment of tyrosine kinase SYK, Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985)


This is TNF receptor-associated factor 5 protein, from Human, contains 557 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases, Mediates activation of NF-kappa-B and probably JNK, Seems to be involved in apoptosis, Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR

Belongs to the TNF receptor-associated factor family, A subfamily


This is Butyrophilin subfamily 3 member A3 protein, from Human, contains 584 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Plays a role in T-cell responses in the adaptive immune response

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Butyrophilin subfamily 3 member A1 protein, from Human, contains 513 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Plays a role in T-cell activation and in the adaptive immune response, Regulates the proliferation of activated T-cells, Regulates the release of cytokines and IFNG by activated T-cells, Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate


This is Nuclear receptor subfamily 5 group A member 2 protein, from Human, contains 541 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis, Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism, Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957), Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation, May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors, Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver, May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development, Activates the transcription of CYP2C38 (By similarity)

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is Zinc finger protein 593 protein, from Human, contains 134 amino acids, has 1 C2H2-type Zinc finger.

Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:32669547), Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity (PubMed:9115366)

Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family


This is Peroxisome assembly protein 12 protein, from Human, contains 359 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:9354782, PubMed:9632816, PubMed:24662292), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:24662292), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is E3 ubiquitin-protein ligase TRIM38 protein, from Human, contains 465 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470), Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity), Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470), Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity), Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549)


This is ATP-dependent RNA helicase glh-3 protein, from Caenorhabditis elegans, contains 720 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Belongs to the DEAD box helicase family, DDX4/VASA subfamily


This is E3 ubiquitin-protein ligase ari-1.1 protein, from Caenorhabditis elegans, contains 494 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein transferase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ubc-18 (By similarity), Acts with ubc-18 to regulate pharyngeal development (PubMed:16457801, PubMed:19521497)

Belongs to the RBR family, Ariadne subfamily


This is Nuclear hormone receptor family member nhr-14 protein, from Caenorhabditis elegans, contains 435 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor (PubMed:10022975), Transcriptional repressor of intestinal metal transporter smf-3 and genes of the innate immune response (PubMed:31532389), Inhibits nuclear localization of transcription factor pqm-1; in response to pathogen stress, may facilitate translocation of pqm-1, leading to transcriptional activation of genes involved in innate immunity and iron uptake (PubMed:31532389)


This is Males-absent on the first protein protein, from Fruit fly, contains 827 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the male-specific lethal (MSL) complex (PubMed:9155031, PubMed:16543150, PubMed:34133927), Dosage compensation ensures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes (PubMed:9155031), May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex (PubMed:11258702), As part of the nonspecific lethal (NLS) complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification (PubMed:20620954)


This is Zinc finger protein ztf-11 protein, from Caenorhabditis elegans, contains 539 amino acids, has 2 CCHHC-type Zinc finger.

CCHHC-type

CCHHC-type

Transcriptional repressor which promotes neuronal differentiation during embryonic and postembryonic neurogenesis (PubMed:31386623), Together with components of the MuvB corepressor complex, negatively regulates the expression of non-neuronal genes during neurogenesis (PubMed:31386623), Required for the generation of postembryonic neurons from epidermal cells (PubMed:31386623)


This is Myosin light chain kinase, smooth muscle protein, from Sheep, contains 438 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC), Also regulates actin-myosin interaction through a non-kinase activity, Phosphorylates PTK2B/PYK2 and myosin light-chains, Involved in the inflammatory response (e,g, apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma, Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance, Necessary for gastrointestinal motility, Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements, In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells, Critical participant in signaling sequences that result in fibroblast apoptosis, Plays a role in the regulation of epithelial cell survival, Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure, Mediates RhoA-dependent membrane blebbing, Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane, Promotes cell migration (including tumor cells) and tumor metastasis, PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI), May regulate optic nerve head astrocyte migration, Probably involved in mitotic cytoskeletal regulation, Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring, Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC, Essential for intestinal barrier dysfunction, Mediates Giardia spp,-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1, Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells (By similarity)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family


This is Estrogen receptor beta protein, from Mouse, contains 530 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Diacylglycerol kinase zeta protein, from Rat, contains 929 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids, Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes, Also plays an important role in the biosynthesis of complex lipids, Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species, Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity), The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity), By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity), Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity), Regulates RASGRP1 activity (By similarity)

Belongs to the eukaryotic diacylglycerol kinase family


This is Steroid hormone receptor ERR1 protein, from Mouse, contains 422 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3', Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter, Binds to the C1 region of the lactoferrin gene promoter, Requires dimerization and the coactivator, PGC-1A, for full activity, The ERRalpha/PGC1alpha complex is a regulator of energy metabolism, Induces the expression of PERM1 in the skeletal muscle (By similarity)


This is Krueppel-like factor 6 protein, from Mouse, contains 283 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional activator, Binds a GC box motif, Could play a role in B-cell growth and development (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Sequestosome-1 protein, from Rat, contains 439 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

More potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2


This is Transcription intermediary factor 1-beta protein, from Rat, contains 835 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger, has 1 PHD-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

PHD-type

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs), Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes, Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression, Recruitment of SETDB1 induces heterochromatinization, May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1, Also a corepressor for ERBB4, Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation, May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1, Important regulator of CDKN1A/p21(CIP1), Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger, Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity, Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6, Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors, In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg), Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells, Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs), In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway, Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing, The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc finger genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions