This is Paired immunoglobulin-like type 2 receptor beta protein, from Human, contains 227 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system, PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface


This is Zinc finger protein 215 protein, from Human, contains 517 amino acids, has 4 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is RING finger protein 150 protein, from Human, contains 438 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Pregnancy-specific beta-1-glycoprotein 11 protein, from Human, contains 335 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, CEA family


This is Endogenous retrovirus group K member 11 Pol protein protein, from Human, contains 969 amino acids, has 1 Integrase-type Zinc finger.

Integrase-type

Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA, The RNase H domain of the reverse transcriptase performs two functions, It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid, Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome, Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity)

Belongs to the beta type-B retroviral polymerase family, HERV class-II K(HML-2) pol subfamily


This is E3 ubiquitin-protein ligase itt1 protein, from Fission yeast, contains 435 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical


This is PAN2-PAN3 deadenylation complex subunit pan3 protein, from Fission yeast, contains 589 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, ppk26/pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1

Belongs to the protein kinase superfamily, PAN3 family


This is RNA polymerase I-specific transcription initiation factor rrn7 protein, from Fission yeast, contains 537 amino acids, has 1 RRN7-type Zinc finger.

Component of RNA polymerase I core factor complex (CF) that acts as a sua7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription, Binds HomolD box in rDNA promoters and plays a role in Pol I recruitment


This is Anaphase-promoting complex subunit 11 protein, from Fission yeast, contains 94 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome


This is 20S-pre-rRNA D-site endonuclease nob1 protein, from Fission yeast, contains 388 amino acids, has 1 NOB1 Zinc finger.

Required for the synthesis of 40S ribosome subunits, Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site), Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm (By similarity)


This is INO80 complex subunit 1 protein, from Fission yeast, contains 249 amino acids, has 2 C2H2-type Zinc finger.

Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair


This is Peroxisome biogenesis factor 10 protein, from Fission yeast, contains 306 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling, The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane, PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase, When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation


This is DNA topoisomerase 1 protein, from Pyrococcus abyssi (strain GE5 / Orsay), contains 685 amino acids, has 1 C4-type Zinc finger, has 1 C4-type 2; atypical Zinc finger.

C4-type 2; atypical

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is Integrator complex subunit 12 protein, from Fruit fly, contains 328 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424, PubMed:23288851), Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424, PubMed:23288851), Required for the normal expression of the Integrator complex component IntS1 (PubMed:23288851), May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity)

Belongs to the Integrator subunit 12 family


This is U1 small nuclear ribonucleoprotein C protein, from Fruit fly, contains 145 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity), Regulates alternative splicing of a distinct group of target genes

Belongs to the U1 small nuclear ribonucleoprotein C family


This is DNA replication licensing factor REC protein, from Fruit fly, contains 885 amino acids, has 1 C4-type Zinc finger.

Required for meiotic DNA recombination in females, Probably not involved in DNA repair and recombination in somatic cells


This is Testis-specific zinc finger protein topi protein, from Fruit fly, contains 814 amino acids, has 10 C2H2-type Zinc finger.

Required for male meiotic division and spermatid differentiation, Required for accumulation of aly and comr on chromatin, May function as a transcription factor


This is E3 ubiquitin-protein ligase Iruka protein, from Fruit fly, contains 380 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates (PubMed:30503771), Recognizes miRNA-empty Ago1 and triggers its degradation via polyubiquitination independently of the Bag6 complex (PubMed:30503771), By targeting miRNA-empty Ago1, eliminates dysfunctional Ago1 not able to bind miRNA and thereby plays a role in the quality control of miRNA-mediated silencing (PubMed:30503771)


This is Inhibitor of growth protein 5 protein, from Fruit fly, contains 285 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the Enok complex which has a histone H3 acetyltransferase activity


This is Pineapple eye protein protein, from Fruit fly, contains 582 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type; atypical Zinc finger.

C2HC pre-PHD-type

PHD-type; atypical

Required for survival of imaginal disk cells possibly by regulation of cell apoptosis (PubMed:14704172), Required for germline stem cell self-renewal through mediation of BMP signaling (PubMed:22413088)


This is 5'-3' exoribonuclease 2 homolog protein, from Fruit fly, contains 908 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Possesses 5'->3' exoribonuclease activity, May promote the termination of transcription by RNA polymerase II (By similarity)

Belongs to the 5'-3' exonuclease family, XRN2/RAT1 subfamily


This is Non-structural maintenance of chromosomes element 1 homolog protein, from Fruit fly, contains 235 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:23555814), The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (By similarity)


This is Cleavage and polyadenylation specificity factor subunit 4 protein, from Fruit fly, contains 296 amino acids, has 5 C3H1-type Zinc finger, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition, Has endonuclease activity, Binds RNA polymers with a preference for G- and/or C-rich clusters, Binds single-stranded DNA non-specifically


This is Protein sister of odd and bowel protein, from Fruit fly, contains 578 amino acids, has 5 C2H2-type Zinc finger.

Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis, DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions (By similarity), May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation


This is Zinc finger CCCH domain-containing protein 3 protein, from Fruit fly, contains 597 amino acids, has 3 C3H1-type Zinc finger.

Required for the export of polyadenylated mRNAs from the nucleu; binds to polyadenylated mRNA, and is involved in the regulation of mRNA polyadenylation


This is Protein sneaky protein, from Fruit fly, contains 715 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of the sperm acrosome membrane (PubMed:17092953), Required for breakdown of the sperm plasma membrane after sperm entry into the egg, which is an essential prerequisite for successful fertilization (PubMed:9630751, PubMed:17092953)

Cytoplasmic vesicle, secretory vesicle, acrosome membrane


This is RING finger protein narya protein, from Fruit fly, contains 211 amino acids, has 1 RING-type Zinc finger.

RING-type

Required for the formation of DNA double-strand breaks (DSBs) together with nenya and vilya during the meiotic recombination process (PubMed:30615609), Plays a role in DSBs processing into crossovers (PubMed:30615609), Plays a redundant role with nenya in chromosome segregation during female meiosis (PubMed:30615609)


This is Histone deacetylase complex subunit SAP30 homolog protein, from Fruit fly, contains 173 amino acids, has 1 Atypical Zinc finger.

Atypical

Component of the class 1 Sin3A-histone deacetylase (HDAC1/Rpd3) complex (HDAC), Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle


This is Protein tamozhennic protein, from Fruit fly, contains 797 amino acids, has 1 RanBP2-type Zinc finger.

Has an essential role during oogenesis and embryogenesis, perhaps in modulating the levels of nuclear import of additional proteins, Modulates the nuclear import of dorsal (dl), Dif and male specific lethal 1 (msl-1), Negatively regulates nuclear import of dl and controls the accumulation of dl in the nucleus after immune challenge


This is Zinc finger protein 277 protein, from Fruit fly, contains 452 amino acids, has 2 C2H2-type Zinc finger.

DNA binding protein which is involved in the positive regulation of both basal and inducible transcription (PubMed:33456983), Mainly localizes to active promoter sites and interacts with components of various transcription and replication regulatory complexes, such as the ORC, SAGA, THO, TFIID and SWI/SNF complexes (PubMed:30713769, PubMed:33456983), It may therefore regulate transcription by promoting the association of these complexes to their binding sites (PubMed:30713769, PubMed:33456983)


This is CXXC-type zinc finger protein 1 protein, from Fruit fly, contains 663 amino acids, has 1 PHD-type Zinc finger, has 1 CXXC-type Zinc finger.

PHD-type

CXXC-type

Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3, Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs, Additionally, is critical for general chromosomal association of Set1


This is Zinc finger protein ZPR1 protein, from Fruit fly, contains 457 amino acids, has 2 C4-type Zinc finger.

Might mediate EGFR and FGFR signal transduction cascades required for lumen formation in tracheal cells


This is Retinoic acid receptor alpha protein, from Japanese pufferfish, contains 447 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Estrogen receptor beta-1 protein, from Goldfish, contains 568 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Retinoic acid receptor beta protein, from Japanese quail, contains 455 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), May be required for Sertoli cell differentiation and spermatogenesis


This is Estrogen receptor beta protein, from Gilthead sea bream, contains 559 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Thyroid hormone receptor alpha protein, from Atlantic halibut, contains 416 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine


This is Neuronal growth regulator 1 protein, from Chicken, contains 352 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May be involved in cell-adhesion, May participate in the regulation of neurite outgrowth in the developing brain

Belongs to the immunoglobulin superfamily, IgLON family


This is Thyroid hormone receptor alpha protein, from Atlantic salmon, contains 416 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Flt3-interacting zinc finger protein 1 protein, from Mouse, contains 500 amino acids, has 11 C2H2-type Zinc finger.

May be a transcriptional repressor of NRL function in photoreceptors, Does not repress CRX-mediated transactivation (By similarity)


This is Four and a half LIM domains protein 5 protein, from Mouse, contains 284 amino acids, has 1 C4-type Zinc finger.

May be involved in the regulation of spermatogenesis, Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity)


This is Zinc finger and BTB domain-containing protein 10 protein, from Rat, contains 836 amino acids, has 2 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Hepatocyte nuclear factor 4-gamma protein, from Mouse, contains 408 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor, Has a lower transcription activation potential than HNF4-alpha (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is E3 ubiquitin-protein ligase TRIM17 protein, from Rat, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation, Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation, Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies, Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity), Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death, In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities, Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity), Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity)


This is Formamidopyrimidine-DNA glycosylase protein, from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4), contains 270 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is DNA primase protein, from Bacillus stearothermophilus, contains 597 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is Zinc finger CCCH domain-containing protein 29 protein, from Mouse-ear cress, contains 597 amino acids, has 2 C3H1-type Zinc finger.

Involved in salt stress response, May positively modulate plant tolerance to salt stress


This is Brassinosteroid-responsive RING protein 1 protein, from Mouse-ear cress, contains 170 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

May be involved in the brassinosteroids (BRs) signaling pathway and regulate the growth and development of rosette leaves (PubMed:28887625), Seems to prevent over development of leaves and inflorescence stems (PubMed:12012249)

Belongs to the RING-type zinc finger family


This is Putative axial regulator YABBY 2 protein, from Mouse-ear cress, contains 184 amino acids, has 1 C4-type Zinc finger.

Involved in the abaxial cell fate determination during embryogenesis and organogenesis


This is SWI/SNF complex subunit SWI3C protein, from Mouse-ear cress, contains 807 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Component of a multiprotein complex equivalent of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors


This is T-cell surface glycoprotein CD1a protein, from Pig, contains 339 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells


This is T-cell surface glycoprotein CD4 protein, from Beluga whale, contains 455 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is Cytotoxic T-lymphocyte protein 4 protein, from Dog, contains 223 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor acting as a major negative regulator of T-cell responses, The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28


This is Estrogen receptor beta protein, from Pig, contains 526 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner


This is Junctional adhesion molecule A protein, from Bovine, contains 298 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Seems to play a role in epithelial tight junction formation, Appears early in primordial forms of cell junctions and recruits PARD3, The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly, Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier, Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration, Involved in platelet activation

Belongs to the immunoglobulin superfamily


This is CXXC-type zinc finger protein 1 protein, from Caenorhabditis elegans, contains 508 amino acids, has 1 CXXC-type Zinc finger.

CXXC-type

Transcriptional activator that exhibits a unique DNA binding specificity for CpG motifs; enriched at promoters containing the trimethylation mark on histone H3 'Lys-4' (H3K4me3) (PubMed:24653213), Forms part of the SET2 complex and interacts with the SIN3S HDAC complex at promoters (PubMed:31602465), Required for H3K4 trimethylation and plays a repressive role in the expression of heat shock and salt-inducible genes (PubMed:30941832), Required for fertility, in cooperation with class I histone deacetylases (HDACs) (PubMed:24653213, PubMed:30941832, PubMed:31602465)


This is Nuclear hormone receptor family member nhr-85 protein, from Caenorhabditis elegans, contains 514 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Belongs to the nuclear hormone receptor family


This is FLYWCH transcription factor 1 protein, from Caenorhabditis elegans, contains 507 amino acids, has 1 FLYWCH-type Zinc finger.

FLYWCH-type

Probable transcription factor (PubMed:18794349), Binds to the DNA sequence motif 5'-[AG]GGCGCCG-3' in the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-2 (PubMed:18794349)


This is Nuclear hormone receptor family member nhr-68 protein, from Caenorhabditis elegans, contains 385 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Probable transcription factor that acts in a feed-forward loop with nhr-10 to activate genes, including itself, involved in the vitamin B12-independent breakdown of the short-chain fatty acid propionate (PubMed:30625328), This pathway is triggered in response to a diet low in vitamin B12, when canonical vitamin B12-dependent propionate breakdown cannot function; the resulting accumulation of propionate is probably sensed by nhr-68 and/or nhr-10 (PubMed:30625328)


This is Nuclear hormone receptor family member nhr-8 protein, from Caenorhabditis elegans, contains 560 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Zinc finger protein 443 protein, from Human, contains 671 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 16 C2H2-type Zinc finger, has 1 C2H2-type 13; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 13; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 652 protein, from Human, contains 606 amino acids, has 7 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 9; degenerate

Functions as a transcriptional repressor


This is Zinc finger protein 510 protein, from Human, contains 683 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 9 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Zinc finger protein with KRAB and SCAN domains 5 protein, from Human, contains 839 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 11; atypical Zinc finger.

C2H2-type 11; atypical


This is Zinc finger protein 257 protein, from Human, contains 563 amino acids, has 11 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 5; degenerate

C2H2-type 9; degenerate


This is Zinc finger and BTB domain-containing protein 12 protein, from Human, contains 459 amino acids, has 4 C2H2-type Zinc finger.


This is Zinc finger protein 37 homolog protein, from Human, contains 630 amino acids, has 11 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 3; atypical


This is Sporulation-specific protein 6 protein, from Fission yeast, contains 474 amino acids, has 1 DBF4-type Zinc finger.

May act as a kinase regulator, Essential for progression of meiosis II and sporulation


This is DNA topoisomerase 1 protein, from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1), contains 673 amino acids, has 1 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is Estrogen receptor beta protein, from Nile tilapia, contains 557 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner


This is Estrogen receptor protein, from Nile tilapia, contains 585 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues


This is Semaphorin-4E protein, from Zebrafish, contains 766 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type


This is Zinc finger protein ZIC 2-B protein, from African clawed frog, contains 497 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation, Regulates anteroposterior patterning in early development by inhibiting expression of the nodal genes through the inhibition of vegt, Required for gastrulation movements and for proper anterior neural and axial development, May also act as a transcriptional activator, May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity)

Belongs to the GLI C2H2-type zinc-finger protein family


This is Endogenous retrovirus group K member 19 Gag polyprotein protein, from Human, contains 666 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle, During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell, Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA, Endogenous Gag proteins may have kept, lost or modified their original function during evolution

Belongs to the beta type-B retroviral Gag protein family, HERV class-II K(HML-2) gag subfamily


This is Zinc finger and BTB domain-containing protein 22 protein, from Mouse, contains 638 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 2 C2H2-type Zinc finger.

C2H2-type 1; atypical

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Natural cytotoxicity triggering receptor 1 protein, from Rat, contains 325 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis

Belongs to the natural cytotoxicity receptor (NCR) family


This is Transcription elongation factor SPT4-B protein, from Mouse, contains 117 amino acids, has 1 C4-type Zinc finger.

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II, DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A, DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter, Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex, DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II, TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme, Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity)


This is Zinc finger protein 394 protein, from Mouse, contains 521 amino acids, has 6 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical


This is Zinc finger protein 394 protein, from Rat, contains 536 amino acids, has 6 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical


This is Formamidopyrimidine-DNA glycosylase protein, from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145), contains 286 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is DNA topoisomerase 1 protein, from Rickettsia prowazekii (strain Madrid E), contains 776 amino acids, has 1 C4-type Zinc finger.


This is DNA topoisomerase 1 protein, from Campylobacter pylori J99, contains 736 amino acids, has 4 C4-type Zinc finger.


This is Zinc-finger homeodomain protein 6 protein, from Mouse-ear cress, contains 262 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate


This is E3 ubiquitin-protein ligase WAVH1 protein, from Mouse-ear cress, contains 683 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in the regulation of root growth, Acts as positive regulator of root gravitropism, Possesses E3 protein ligase activity in vitro


This is Poly [ADP-ribose] polymerase 1 protein, from Maize, contains 980 amino acids, has 2 PARP-type Zinc finger.

PARP-type

PARP-type

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity)


This is Probable E3 ubiquitin-protein ligase ATL45 protein, from Mouse-ear cress, contains 200 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that possess E3 ubiquitin ligase activity in vitro and mediates protein monoubiquitination (Ref,10), Triggers the monoubiquitination of phosphorylated BIK1 in response to pathogen-associated molecular pattern (PAMP) detection (Ref,10), May be involved in the early steps of the plant defense signaling pathway (Probable)

Belongs to the RING-type zinc finger family, ATL subfamily


This is Plant UBX domain-containing protein 2 protein, from Mouse-ear cress, contains 458 amino acids, has 1 C2H2-type; atypical Zinc finger.

C2H2-type; atypical

Facilitates the interaction of SYP31 and CDC48A, thereby regulating an CDC48A membrane-associated function (Ref,8), Appears to act as a negative regulator mediating the powdery mildew-plant interaction (PubMed:19176722, PubMed:23301616)


This is Putative RING-H2 finger protein ATL49 protein, from Mouse-ear cress, contains 423 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

May be involved in female gametophyte development


This is General transcription factor IIH subunit 2 protein, from Mouse-ear cress, contains 421 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription (By similarity), Can restore UV resistance in the NER-deficient ssl1-1 yeast mutant (PubMed:16623910)


This is KIN17-like protein protein, from Mouse-ear cress, contains 411 amino acids, has 1 C2H2-type Zinc finger.

Promotes the copper deficiency response by direct interaction with SPL7, Acts with SPL7 in a common pathway to promote copper-responsive genes and alleviate oxidative stress during copper-limiting periods, May promote SPL7 function when copper is limiting (PubMed:24335506), Participates in the control of general plant growth and development, and in the response to counteract the negative effects of UV radiation (PubMed:24713636)


This is Zinc finger CCCH domain-containing protein 2 protein, from Mouse-ear cress, contains 393 amino acids, has 2 C3H1-type Zinc finger.

Probable transcription repressor that functions as negative regulator of phytochrome-mediated promotion of seed germination, Inhibits seed germination by regulating the expression of gibberellic acid (GA) and abscisic acid (ABA) metabolic genes, Does not regulate the expression of the DELLA genes RGA and RGA1, Activated by PIL5, a phytochrome-interacting basic helix-loop-helix transcription factor (PubMed:18487351), Represses directly JMJ20 and JMJ22 expression in the absence of red light (R) and in far-red (FR) conditions (PubMed:22483719)


This is Squamosa promoter-binding protein-like 15 protein, from Alpine rock-cress, contains 355 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Probable transcription factor required for the flowering response to vernalization in the shoot apical meristem (SAM) (PubMed:30679374), Defines the competence of shoot meristems to flower in response to vernalization in perennials (PubMed:30679374)


This is Sperm acrosome membrane-associated protein 6 protein, from Human, contains 324 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Sperm protein required for fusion of sperm with the egg membrane during fertilization


This is Probable non-functional immunoglobulin kappa variable 3-7 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447), Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Probable non-functional immunoglobulin kappa variable 1D-42 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 4-69 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)


This is Immunoglobulin lambda variable 8-61 protein, from Human, contains 122 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 4-60 protein, from Human, contains 120 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin lambda variable 11-55 protein, from Human, contains 123 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 10-54 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin lambda variable 1-50 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin lambda variable 5-48 protein, from Human, contains 105 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 7-46 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 5-37 protein, from Human, contains 123 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin lambda variable 2-33 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 3-22 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 2-18 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 3-16 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 3-12 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 3-10 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 3-9 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 4-3 protein, from Human, contains 122 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor gamma variable 11 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447), Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395), Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1, Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588), Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT, This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089), Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes, The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames, The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714)


This is Probable non-functional T cell receptor beta variable 7-3 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447), Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is T cell receptor beta variable 20-1 protein, from Human, contains 111 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is T cell receptor beta variable 24-1 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 25-1 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 2-28 protein, from Human, contains 120 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin heavy variable 3-64 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is T cell receptor gamma variable 2 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447), Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1, Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588), Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT, This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089), Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes, The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames, The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714)


This is Immunoglobulin heavy variable 4-4 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin kappa variable 2D-24 protein, from Human, contains 120 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 2D-29 protein, from Human, contains 120 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1D-17 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1-27 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 2D-30 protein, from Human, contains 120 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulinn kappa variable 1-37 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 12-2 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is T cell receptor alpha variable 6 protein, from Human, contains 132 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 9-1 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 7 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 36/delta variable 7 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 23/delta variable 6 protein, from Human, contains 121 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 18 protein, from Human, contains 111 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 5-45 protein, from Human, contains 123 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 4-30-2 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 3D-15 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1D-8 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 30 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 9-2 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 26-1 protein, from Human, contains 109 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 16 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 2-40 protein, from Human, contains 121 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor beta variable 17 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 18 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 2D-26 protein, from Human, contains 120 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 3D-11 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 5-52 protein, from Human, contains 124 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin lambda variable 3-32 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor gamma variable 10 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor gamma variable protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor beta variable 5-3 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor beta variable 6-7 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor beta variable 5-7 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor beta variable 23-1 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 1-45 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-49 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 6D-21 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 14/delta variable 4 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 13 protein, from Human, contains 124 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 6-6 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 6-8 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 8-3 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 8-1 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional T cell receptor beta variable 7-1 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 16 protein, from Human, contains 109 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 19 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is C2H2 type master regulator of conidiophore development brlA protein, from Cephalosporium acremonium, contains 376 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger.

C2H2-type 1; degenerate

BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (PubMed:26283234), They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity), Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity)


This is C2H2 type master regulator of conidiophore development BrlA protein, from Metarhizium anisopliae (strain ARSEF 23), contains 368 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger.

C2H2-type 1; degenerate

BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation, They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (PubMed:29958281), BrlA, abaA and wetA act together to positively regulate the expression of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:29958281)


This is Immunoglobulin lambda variable 1-36 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor gamma variable 5 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 9 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 6-1 protein, from Human, contains 121 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-15 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-21 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 2-26 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-73 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin heavy variable 7-81 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447), Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin heavy variable 3-74 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-43 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 9-49 protein, from Human, contains 123 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-72 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1D-43 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 2 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 13-2 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 8-2 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 1-2 protein, from Human, contains 106 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 10 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 13-1 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 3 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 12-1 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 1-1 protein, from Human, contains 108 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 5 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 8-6 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 39 protein, from Human, contains 110 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 38-1 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 26-2 protein, from Human, contains 109 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 41 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 4 protein, from Human, contains 109 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 12-3 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 24 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 34 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 20 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 17 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 25 protein, from Human, contains 109 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 22 protein, from Human, contains 110 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 21 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 40 protein, from Human, contains 105 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1D-13 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 12-4 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 1-69D protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 6-21 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 3D-20 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin kappa variable 6D-41 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor gamma variable 8 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor gamma variable 4 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 1-3 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin heavy variable 3-16 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 1-18 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-20 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 1-24 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 4-28 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin heavy variable 3-35 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Probable non-functional immunoglobulin heavy variable 3-38 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 5-51 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 1-58 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 4-61 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-66 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 2-70D protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 3D-7 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 5-4 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1-8 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 2-24 protein, from Human, contains 120 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1-9 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1-6 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1-12 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Transcription regulator rua1 protein, from Corn smut fungus, contains 757 amino acids, has 1 C2H2-type 1 degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 1 degenerate

C2H2-type 2; degenerate

Transcription factor; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA) (PubMed:17850255, PubMed:20173069), UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U,maydis (PubMed:17850255), Recognizes and binds to the specific 5'-T/G-G/T-C-G-C-A-T-A/T-C/T-C/T-G/A-3' upstream activating sequence found in all promoters of the UA biosynthesis genes (PubMed:20173069)


This is Immunoglobulin heavy variable 1-69-2 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 5-39 protein, from Human, contains 123 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Leukocyte immunoglobulin-like receptor subfamily B member 3-like protein, from Rat, contains 761 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Immunoglobulin heavy variable 7-4-1 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-64D protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 6-9 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 5-10-1 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 6-2 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 10-1 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 30 protein, from Human, contains 111 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 11-1 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 27 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 6-1 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 7-7 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 10-3 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 10-2 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Transcription factor COE1-A protein, from Zebrafish, contains 591 amino acids, has 1 C5-type Zinc finger.


This is C2H2-type zinc-finger transcription factor frbF protein, from Fungal sp. (strain No.11243), contains 361 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

C2H2-type zinc-finger transcription factor; part of the gene cluster that mediates the biosynthesis of the antifungal antibiotic FR901469, an inhibitor of beta-1,3-glucansynthase, exerting antifungal activity against the pathogenes Candida albicans and Aspergillus fumigatus (PubMed:27660098), FR901469 is a cyclic depsipeptide containing 12 amino acid residues and a fatty acid chain (PubMed:27660098), Positively regulates the expression of the FR901469 biosynthesis cluster genes frbA, frbB, frbC, frbG, frbH and frbI (PubMed:27660098, PubMed:28341398), Affects also the expression of some genes involved in other metabolic pathways, including the ergosterol biosynthetic pathway, beta-1,3-glucan catabolic enzymes or chitinases (PubMed:27660098)


This is T cell receptor beta variable 7-6 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 6-4 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 7-8 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor delta variable 1 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447), Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1, Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415), Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT, This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089), Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes, The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames, The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714)


This is T cell receptor beta variable 2 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 12-5 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 7-4 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 7-2 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Large ribosomal subunit protein eL37 protein, from Yeast, contains 90 amino acids, has 1 A20-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL37 family


This is Peroxisome assembly protein 12-A protein, from African clawed frog, contains 353 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:35931083), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is Protein ZAR1-like 1.L protein, from African clawed frog, contains 281 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation, Controls timing of meiosis during oogenesis (By similarity), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (By similarity)

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is Zygote arrest protein 1.L protein, from African clawed frog, contains 312 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (By similarity), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of maternal mRNAs in immature oocytes, inhibiting their translation (By similarity)


This is Transcription factor verF protein, from Penicillium polonicum, contains 730 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Transcription factor; part of the gene cluster that mediates the biosynthesis of the neurotoxin verrucosidin, a methylated alpha-pyrone polyketide that inhibits oxidative phosphorylation in mitochondria and thereby causes neurological diseases


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Arabian coffee, contains 494 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Putative tripartite motif-containing protein 51G protein, from Human, contains 452 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is T cell receptor beta variable 4-2 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is T cell receptor beta variable 3-1 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 4-1 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 5-1 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 11-2 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 4-3 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 5-5 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 5-6 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 5-8 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 11-3 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 14 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 28 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 29-1 protein, from Human, contains 111 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is host range factor p28 protein, from Monkeypox virus, contains 242 amino acids, has 1 RING-type Zinc finger.

RING-type

RING-finger E3 ubiquitin ligase which catalyzes the formation of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, Plays an important role in virulence by acting as an anti-apoptotic factor

Belongs to the orthopoxvirus OPG021 family


This is DNA-directed RNA polymerase 30 kDa polypeptide protein, from Monkeypox virus, contains 259 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates, Responsible for the transcription of early, intermediate and late genes, DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG134, thereby allowing the early genes transcription, Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase

Belongs to the poxviridae DNA-directed RNA polymerase 30 kDa subunit family


This is Chaperone protein DnaJ protein, from Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8), contains 376 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8), contains 294 amino acids, has 1 C4-type Zinc finger.


This is Zinc finger protein ZIC 4 protein, from African clawed frog, contains 530 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

May bind to DNA (By similarity), Induces neural and neural crest differentiation, Does not induce anterior neural tissue


This is T cell receptor alpha variable 38-2/delta variable 8 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is T cell receptor delta variable 2 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor delta variable 3 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Myelin protein P0 protein, from Western clawed frog, contains 243 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae


This is Lateral signaling target protein 2 homolog protein, from Zebrafish, contains 969 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Negative regulator of epidermal growth factor receptor (EGFR) signaling, Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity)


This is RNA-binding protein 5-A protein, from African clawed frog, contains 833 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type Zinc finger.

Component of the spliceosome A complex, Regulates alternative splicing of a number of mRNAs, May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity)


This is General transcription factor IIH subunit 2 protein, from Rat, contains 396 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription, The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter


This is Polycomb group RING finger protein 5 protein, from Bovine, contains 255 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity), Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity)


This is Nuclear receptor subfamily 2 group C member 1 protein, from Bovine, contains 608 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism, Primarily repressor of a broad range of genes including ESR1 and RARB, Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity), Also activator of OCT4 gene expression, Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation, Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity)