This is F-box/LRR-repeat protein 19 protein, from Human, contains 694 amino acids, has 1 CXXC-type Zinc finger, has 1 PHD-type Zinc finger.

CXXC-type

PHD-type

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:24684802, PubMed:29522376), Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner (PubMed:23871831), Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration (PubMed:24684802, PubMed:23512198), Mediates also ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (By similarity), Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034), Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation, In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (By similarity)


This is E3 ubiquitin-protein ligase TRIM37 protein, from Mouse, contains 961 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type; degenerate

B box-type

E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity), Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity), Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042), Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (By similarity)


This is E3 ubiquitin-protein ligase Rnf220 protein, from Mouse, contains 566 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (PubMed:20170641), Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity), Plays a critical role in the regulation of nuclear lamina


This is Zinc finger CCHC domain-containing protein 12 protein, from Human, contains 402 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway, It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex, It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)


This is E3 ubiquitin-protein ligase arih1 protein, from Zebrafish, contains 527 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3, Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets, The initial ubiquitin is then elongated, E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes

Belongs to the RBR family, Ariadne subfamily


This is E3 ubiquitin-protein ligase TRIM45 protein, from Mouse, contains 580 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779), Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response, May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway


This is E3 ubiquitin-protein ligase TRIM65 protein, from Human, contains 517 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:28594402, PubMed:34512673), Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (PubMed:24778252), This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (PubMed:31160576), Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade (PubMed:28594402), Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (PubMed:33373584), Plays also a role in limitation of inflammation through different mechanisms, First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649), In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673)


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 4 protein, from Human, contains 635 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Promotes neurite outgrowth in hippocampal neurons, May play a role in redistributing DLG4 to the cell periphery (By similarity)


This is Zinc finger CCCH domain-containing protein 14 protein, from Human, contains 736 amino acids, has 5 C3H1-type Zinc finger.

Involved in poly(A) tail length control in neuronal cells, Binds the polyadenosine RNA oligonucleotides


This is E3 ubiquitin-protein ligase TRAF7 protein, from Human, contains 670 amino acids, has 1 RING-type Zinc finger, has 1 TRAF-type Zinc finger.

RING-type

TRAF-type

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3, Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216), Induces apoptosis when overexpressed (PubMed:15001576), Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3


This is Peptidyl-prolyl cis-trans isomerase CYP59 protein, from Mouse-ear cress, contains 506 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Influences somehow regulation of RNA pol II (CTD) phosphorylation, Binds RNA with preferences for GC-rich sequences, Probably involved in activities connecting transcription and pre-mRNA processing, Involved in brassinostroid response

Belongs to the cyclophilin-type PPIase family


This is Androgen receptor protein, from Rhesus macaque, contains 895 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation, Transcription activation is also down-regulated by NR0B2, Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Endonuclease 8-like 2 protein, from Mouse, contains 329 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles), Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is E3 ubiquitin-protein ligase RMA1H1 protein, from Capsicum pepper, contains 252 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for aquaporin levels regulation


This is Chaperone protein DnaJ protein, from Agrobacterium tumefaciens, contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)


This is Zinc finger protein JAGGED protein, from Mouse-ear cress, contains 253 amino acids, has 1 C2H2-type Zinc finger.

Controls the morphogenesis of lateral organs, Functions in lateral organ shape and is sufficient to induce proliferation and growth of lateral organ tissue, Is necessary and sufficient for bract formation, but its expression is excluded from the cryptic bract, which could be a cause of bractless flowers in Arabidopsis, Participates with FIL and YAB3 in regulating valve margin development, Functions with JGL to define stamen and carpel shape, Functions with AS1 and AS2 in the sepal and petal primordia to repress boundary-specifying genes for normal development of the organs


This is mRNA decay activator protein ZFP36 protein, from Sheep, contains 325 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis, Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery, Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation, Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, Self regulates by destabilizing its own mRNA, Binds to 3'-UTR ARE of numerous mRNAs, Binds also to ARE of its own mRNA, Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages, Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response, Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia, Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs), Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA, Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA, Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs, Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs, May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro, Involved in the delivery of target ARE-mRNAs to processing bodies (PBs), In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing, Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages, Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion, Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis, Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells


This is Zinc finger protein 474 protein, from Human, contains 364 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate


This is CMRF35-like molecule 8 protein, from Mouse, contains 318 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:12874256, PubMed:12893283, PubMed:16339535), Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity)


This is CMRF35-like molecule 3 protein, from Mouse, contains 245 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Acts as an activating receptor inducing cytokine production in mast cells, Can act as a positive regulator of TLR9 signaling in macrophages, leading to enhanced production of pro-inflammatory cytokines


This is CMRF35-like molecule 1 protein, from Mouse, contains 337 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

(Microbial infection) Acts as a functional murine norovirus (MNV) receptor that mediates binding to the cell surface and is both necessary and sufficient for viral entry and replication, Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV, Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27681626, PubMed:27540007)


This is Probable E3 ubiquitin-protein ligase rbrA protein, from Social amoeba, contains 520 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, Appears to be required for normal cell-type proportioning and cell sorting during multicellular development, In addition to being necessary for a normal percentage of prestalk cells and the organization of the slug, rbrA is also necessary for spore cell viability


This is Beta-2-microglobulin protein, from Olive baboon, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system (By similarity)

Belongs to the beta-2-microglobulin family


This is E3 ubiquitin-protein ligase MYLIP-A protein, from Zebrafish, contains 472 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity), Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway


This is NF-kappa-B essential modulator protein, from Rat, contains 412 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor, Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways, Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin, Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity, Essential for viral activation of IRF3, Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination


This is Zinc finger protein 322 protein, from Human, contains 402 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 8 C2H2-type Zinc finger, has 1 C2H2-type 10; degenerate Zinc finger, has 1 C2H2-type 11; degenerate Zinc finger.

C2H2-type 1; atypical

C2H2-type 10; degenerate

C2H2-type 11; degenerate

Transcriptional activator (PubMed:15555580), Important for maintenance of pluripotency in embryonic stem cells (By similarity), Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity), Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity), Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is T-cell immunoglobulin and mucin domain-containing protein 4 protein, from Mouse, contains 343 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135), Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways, Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:18354194, PubMed:18367551), Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (By similarity), Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038)

Belongs to the immunoglobulin superfamily, TIM family


This is Forkhead box protein P3 protein, from Crab-eating macaque, contains 431 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg), Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells, Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases, The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG), Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2, Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7, Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1, Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development, Inhibits the transcriptional activator activity of RORA (By similarity), Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity)


This is E3 ubiquitin-protein ligase LRSAM1 protein, from Human, contains 723 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501), Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322), Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098)


This is Kin of IRRE-like protein 2 protein, from Human, contains 708 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily


This is V-set and transmembrane domain-containing protein 1 protein, from Human, contains 236 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory immune receptor involved in the regulation of phagocytes


This is Butyrophilin-like protein 8 protein, from Human, contains 500 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

May stimulate primary immune response, Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is CMRF35-like molecule 9 protein, from Human, contains 332 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Receptor which may mediate L-selectin-dependent lymphocyte rollings, Binds SELL in a calcium dependent manner, Binds lymphocyte (By similarity)


This is Butyrophilin-like protein 9 protein, from Human, contains 535 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Immunoglobulin superfamily containing leucine-rich repeat protein 2 protein, from Human, contains 745 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Required for axon extension during neural development


This is Transmembrane and immunoglobulin domain-containing protein 1 protein, from Human, contains 262 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival


This is CMRF35-like molecule 5 protein, from Human, contains 194 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Netrin receptor UNC5D protein, from Human, contains 953 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity), Plays a role in cell-cell adhesion and cell guidance, Receptor for netrin involved in cell migration, Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity), May play a role in apoptosis in response to DNA damage (PubMed:24691657), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068), Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity)


This is Carcinoembryonic antigen-related cell adhesion molecule 20 protein, from Human, contains 596 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response

Belongs to the immunoglobulin superfamily, CEA family


This is Beta-2-microglobulin protein, from Rhesus macaque, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Kinase suppressor of Ras 2 protein, from Human, contains 950 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Location-regulated scaffold connecting MEK to RAF, Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro), Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126), Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro), Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling, Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family


This is NT-3 growth factor receptor protein, from Mouse, contains 825 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in nervous system and probably heart development, Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is E3 ubiquitin-protein ligase NHLRC1 protein, from Human, contains 395 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways, In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS), Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation, Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation, Also promotes proteasome-independent protein degradation through the macroautophagy pathway


This is Protein M2-1 protein, from HMPV, contains 187 amino acids, has 1 C3H1-type Zinc finger.

Essential for viral replication in vivo (PubMed:15890897), Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding (By similarity)

Belongs to the pneumoviridae M2-1 protein family


This is Kin of IRRE-like protein 1 protein, from Rat, contains 789 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Required for proper function of the glomerular filtration barrier, It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (By similarity), It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity)


This is Cell surface glycoprotein CD200 receptor 4 protein, from Mouse, contains 270 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Involved in the recruitment or surface expression of the TYROBP receptor


This is Glucocorticoid receptor protein, from White-tufted-ear marmoset, contains 777 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression


This is Zinc finger protein GLIS3 protein, from Mouse, contains 780 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Acts as both a repressor and activator of transcription, Binds to the consensus sequence 5'-GACCACCCAC-3'

Belongs to the GLI C2H2-type zinc-finger protein family


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Rat, contains 249 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG), Binds with intermediate affinity to both IgG2a and IgG2b, Can bind to IgG2a and IgG2b monomers, Does not display binding to IgG1 or IgG3 (By similarity), Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC), Confers protection to lethal influenza virus infection (By similarity), On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (By similarity), Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (By similarity), Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (By similarity), Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE), Binds with low affinity to both the a and b allotypes of IgE, Has also been shown to bind to IgE allotype a only but not to allotype b, Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes, Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821)


This is Protein CYTOKININ-RESPONSIVE GATA TRANSCRIPTION FACTOR 1 protein, from Rice, contains 353 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters (By similarity), Influences the expression of nuclear encoded chloroplast-targeted genes, Regulates chloroplast development and promotes chlorophyll accumulation, Modulates plant architecture (e,g, height, length and width of leaf blades, and flowering tillers production) and represses tillering, probably by modulating number of cells, Promotes senescence, Involved in grain filling, panicle development and starch production (PubMed:23548780)

Belongs to the type IV zinc-finger family, Class B subfamily


This is Replication protein A 70 kDa DNA-binding subunit A protein, from Rice, contains 656 amino acids, has 1 C4-type Zinc finger.

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication, The activity of RPA is mediated by single-stranded DNA binding and protein interactions, Plays an essential role in meiotic and somatic DNA repair, but is dispensable for DNA replication and homologous recombination, Is essential for normal progression through meiosis in pollen mother cells, Is involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses

Belongs to the replication factor A protein 1 family


This is Sialic acid-binding Ig-like lectin 15 protein, from Human, contains 328 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is Zinc finger protein 783 protein, from Human, contains 546 amino acids, has 4 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is SH3 and cysteine-rich domain-containing protein 2 protein, from Human, contains 411 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity, Slows down the inactivation rate of the calcium channel CACNA1C


This is Lysine-specific demethylase 7A protein, from Human, contains 941 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone demethylase required for brain development, Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853), Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2, Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638), Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853)

Belongs to the JHDM1 histone demethylase family, JHDM1D subfamily


This is Tripartite motif-containing protein 72 protein, from Human, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites, Specifically binds phosphatidylserine, Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site, This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation, Probably acts upstream of the Ca(2+)-dependent membrane resealing process, Required for transport of DYSF to sites of cell injury during repair patch formation, Regulates membrane budding and exocytosis, May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity)


This is E3 ubiquitin-protein ligase RNF19B protein, from Human, contains 732 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036), Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909), Protects against staurosporin-induced cell death (PubMed:27485036)

Belongs to the RBR family, RNF19 subfamily


This is RNA-binding protein MEX3B protein, from Human, contains 569 amino acids, has 1 RING-type Zinc finger.

RING-type

RNA-binding protein, May be involved in post-transcriptional regulatory mechanisms


This is Protein lin-28 homolog B protein, from Human, contains 250 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c, Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463), Does not act on pri-miR21 (PubMed:22118463), The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation, When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396), This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463), Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop, Mediates MYC-induced let-7 repression (By similarity), When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7, Isoform 2 has no effect on cell growth


This is Zinc finger protein AEBP2 protein, from Human, contains 517 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:31959557, PubMed:29499137), Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137)

Belongs to the AEBP2/jing C2H2-type zinc-finger family


This is Netrin receptor UNC5A protein, from Human, contains 842 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance, Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1, Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin, Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion, It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand


This is Zinc finger protein ZFP2 protein, from Human, contains 461 amino acids, has 13 C2H2-type Zinc finger.

Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance


This is E3 ubiquitin-protein ligase Arkadia protein, from Human, contains 994 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase (PubMed:26656854), Required for mesoderm patterning during embryonic development (By similarity), Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693), Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693), In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity), Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695), Associates with UBE2D2 as an E2 enzyme (PubMed:22411132), Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493), Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493), Mediates ubiquitination and degradation of sumoylated PML (By similarity), The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity)


This is RUN and FYVE domain-containing protein 4 protein, from Human, contains 571 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Positively regulates macroautophagy in primary dendritic cells, Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes, Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger


This is Zinc finger protein 620 protein, from Human, contains 422 amino acids, has 8 C2H2-type Zinc finger.


This is Zinc finger protein 497 protein, from Human, contains 498 amino acids, has 14 C2H2-type Zinc finger.


This is Protein Jade-1 protein, from Mouse, contains 834 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity, Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation, May also promote acetylation of nucleosomal histone H4 by KAT5, Promotes apoptosis, May act as a renal tumor suppressor, Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function


This is PHD finger protein 21A protein, from Mouse, contains 688 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells, The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier, In the BHC complex, it may act as a scaffold, Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity)


This is E3 ubiquitin-protein ligase MARCHF6 protein, from Mouse, contains 909 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation, Promotes ubiquitination of DIO2, leading to its degradation, Promotes ubiquitination of SQLE, leading to its degradation, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, May cooperate with UBE2G1


This is E3 ubiquitin-protein ligase Jade-2 protein, from Mouse, contains 829 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (By similarity), Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020), Also acts as a ubiquitin ligase E3 toward itself (PubMed:25018020), Positive regulator of neurogenesis (PubMed:25018020)


This is Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 protein, from Mouse, contains 770 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6)


This is E3 ubiquitin-protein ligase rififylin protein, from Mouse, contains 377 amino acids, has 1 FYVE-type Zinc finger, has 1 RING-type Zinc finger.

FYVE-type

RING-type

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins, Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex, Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors, Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation, Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation, Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN, May also play a role in endocytic recycling


This is RING finger protein 207 protein, from Human, contains 634 amino acids, has 1 RING-type Zinc finger, has 1 B box-type; atypical Zinc finger.

RING-type

B box-type; atypical

Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner


This is Zinc finger and BTB domain-containing protein 49 protein, from Human, contains 765 amino acids, has 7 C2H2-type Zinc finger.

Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1, Does not bind directly RB1 promoter


This is E3 ubiquitin-protein ligase ARK2C protein, from Human, contains 346 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation, Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP, Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL


This is Small ribosomal subunit protein eS27 protein, from Mouse, contains 84 amino acids, has 1 C4-type Zinc finger.

Component of the small ribosomal subunit (PubMed:36517592), The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592), Required for proper rRNA processing and maturation of 18S rRNAs (By similarity), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)

Belongs to the eukaryotic ribosomal protein eS27 family


This is Zinc finger protein JACKDAW protein, from Mouse-ear cress, contains 503 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor that, together with BIB, regulates tissue boundaries and asymmetric cell division by a rapid up-regulation of 'SCARECROW' (SCR), thus controlling the nuclear localization of 'SHORT-ROOT' (SHR) and restricting its action (PubMed:17785527, PubMed:25829440), Binds DNA via its zinc fingers (PubMed:28211915, PubMed:24821766), Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766), Confines CYCD6 expression to the cortex-endodermis initial/daughter (CEI/CEID) tissues (PubMed:25829440), Required for radial patterning and stem cell maintenance (PubMed:17785527), Counteracted by 'MAGPIE' (MGP) (PubMed:17785527), Binds to the SCR and MGP promoter sequences (PubMed:21935722), Controls position-dependent signals that regulate epidermal-cell-type patterning (PubMed:20356954)


This is Gag polyprotein protein, from HIV-1, contains 500 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Ubiquitin carboxyl-terminal hydrolase 49 protein, from Human, contains 688 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing, Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons


This is Ubiquitin carboxyl-terminal hydrolase 51 protein, from Human, contains 711 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998), USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1, Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998)


This is Ubiquitin carboxyl-terminal hydrolase 45 protein, from Human, contains 814 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Catalyzes the deubiquitination of SPDL1 (PubMed:30258100), Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220), May be involved in the maintenance of photoreceptor function (PubMed:30573563), May play a role in normal retinal development (By similarity), Plays a role in cell migration (PubMed:30258100)


This is Protein ZNF365 protein, from Human, contains 407 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Involved in the regulation of neurogenesis, Negatively regulates neurite outgrowth (PubMed:17389905), Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis, Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth, Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity), Involved in homologous recombination (HR) repair pathway, Required for proper resolution of DNA double-strand breaks (DSBs) by HR, Is required for recovery of stalled replication forks, and directly contributes to genomic stability, Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166), Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040)

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome


This is Origin of replication complex subunit 1A protein, from Mouse-ear cress, contains 809 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Essential protein (PubMed:19171893), Component of the origin recognition complex (ORC) that binds origins of replication, It has a role in both chromosomal replication and mating type transcriptional silencing, Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity), H3K4me3 effector that regulates positively the transcription of a subset of genes (PubMed:19171893)


This is E3 ubiquitin-protein ligase SH3RF1 protein, from Rat, contains 894 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity, In the absence of an external substrate, it can catalyze self-ubiquitination, Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (By similarity), Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway (PubMed:12514131), Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation, Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells, Plays a crucial role in the migration of neocortical neurons in the developing brain, Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity)


This is E3 ubiquitin-protein ligase ZNRF2 protein, from Mouse, contains 238 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Immunoglobulin-like domain-containing receptor 2 protein, from Human, contains 639 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion, With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity), Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694), In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity)

Belongs to the immunoglobulin superfamily, LISCH7 family


This is Small ribosomal subunit protein eS27 protein, from Rat, contains 84 amino acids, has 1 C4-type Zinc finger.

Component of the small ribosomal subunit, The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, Required for proper rRNA processing and maturation of 18S rRNAs, Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome


This is Ribosomal protein eS27-like protein, from Human, contains 84 amino acids, has 1 C4-type Zinc finger.


CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-2, contains 521 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-2, contains 519 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-1, contains 504 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Histone acetyltransferase ESA1 protein, from Yeast, contains 435 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


This is E3 ubiquitin-protein ligase Hakai protein, from Human, contains 491 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity), Targets CDH1 for endocytosis and degradation (By similarity), Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755), Its function in the WMM complex is unknown (PubMed:29507755)


This is Netrin receptor UNC5C protein, from Rat, contains 931 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance (By similarity), Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity), NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity), Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity), Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity), Also involved in corticospinal tract axon guidance independently of DCC (By similarity), Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206)


This is Rab effector Noc2 protein, from Mouse, contains 302 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells, Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A, Acts as a potential RAB3B effector protein in epithelial cells


This is Mast/stem cell growth factor receptor Kit protein, from White-tufted-ear marmoset, contains 972 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis, In response to KITLG/SCF binding, KIT can activate several signaling pathways, Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL, Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B, Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Gag polyprotein protein, from HIV-1, contains 498 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Squamosa promoter-binding-like protein 14 protein, from Rice, contains 417 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Transcriptional activator that binds to the SBP-box DNA core binding motif 5'-GTAC-3' (PubMed:24170127), Can target the TCP motif 5'-TGGGCC/T-3' through interaction with PCF1 and PCF2 (PubMed:24170127), Key regulator of the plant architecture that controls shoot branching and panicle development (PubMed:20495565, PubMed:20495564, PubMed:22960246), Promotes panicle branching (PubMed:20495565, PubMed:20495564, PubMed:22960246, PubMed:26519999), Promotes high grain yield (PubMed:20495565, PubMed:20495564, PubMed:26519999), Binds to the promoters of TB1 and DEP1 (PubMed:24170127), Suppresses rice tillering mainly through positive regulation of TB1 (PubMed:24170127), Regulates plant height and panicle length through positive regulation of DEP1 (PubMed:24170127), Repressed by D53 in strigolactone (SL) signaling (PubMed:28809396), Acts with D53 to mediate the SL-regulated tiller development (PubMed:28809396), Functions as a direct downstream component of D53 in regulating tiller number and SL-induced gene expression (PubMed:28809396), Binds directly to the D53 promoter and plays a critical role in the negative feedback regulation of SL-induced D53 expression (PubMed:28809396), Involved in defense response against pathogens (PubMed:30190406, PubMed:30886331), Phosphorylated at Ser-163 in response to infection by the fungal pathogen Magnaporthe oryzae (PubMed:30190406), Phosphorylation reduces SPL14/IPA1 binding to the GTAC site in the DEP1 promoter and enhances binding to the TGGGCC site in the WRKY45 promoter (PubMed:30190406), Binding to the promoter of the pathogen defense gene WRKY45 activates its expression, leading to enhanced disease resistance (PubMed:30190406), Reduces gibberellin-mediated disease susceptibility by stabilizing SLR1 (PubMed:30886331), Possesses transactivation activity in yeast cells (PubMed:20495564)


This is Zinc finger transcription factor ref-2 protein, from Caenorhabditis elegans, contains 315 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; degenerate

Transcription factor (PubMed:26073017), Modulates expression of target genes by binding to regulatory elements (PubMed:26073017), Required for normal cell division timing and cell positioning in anterior lineages, acting in a cell-autonomous manner (PubMed:35660370), Required for development, fusion and fate of cells of the ventral epidermis, the Pn,p cells, during larval development; acts in concert with homeobox genes lin-39 and mab-5 (PubMed:12091304), Required for the specification of the AIY interneuron (PubMed:19386265), In complex with TCF transcription factor pop-1, positively modulates expression of LIM/homeobox protein ttx-3 in anterior daughter cells of the SMDD/AIY neuron lineage (PubMed:19386265, PubMed:26073017)


This is Protein teflon protein, from Fruit fly, contains 649 amino acids, has 3 C2H2-type Zinc finger.

Specifically required in males for proper segregation of autosomal bivalents at meiosis I, Expression is required in the male germ line prior to spermatocyte stage S4, May have a role as a bridging molecule maintaining adhesion to hold autosome bivalents together via heterochromatic connections


This is Longitudinals lacking protein, isoforms A/B/D/L protein, from Fruit fly, contains 787 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is Protein TRC8 homolog protein, from Fruit fly, contains 809 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6, May modulate signalosome levels or compartmentalization, Probably functions in the same or a related pathway to VHL during early midline development


This is Transcriptional adapter 2A protein, from Fruit fly, contains 562 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II-dependent transcription


This is E3 ubiquitin-protein ligase parkin protein, from Fruit fly, contains 482 amino acids, has 1 RING-type 0; atypical Zinc finger, has 1 RING-type Zinc finger, has 2 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type 0; atypical

RING-type

IBR-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as Paris, Marf, Opa1, Miro, pnut, Septin1, Tom20 and porin (PubMed:16002472, PubMed:17456438, PubMed:25474007, PubMed:20194754, PubMed:24192653, PubMed:24901221, PubMed:27906179, PubMed:31714929, PubMed:32138754, PubMed:32047033, PubMed:23770917), Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates, depending on the context (PubMed:18957282, PubMed:24901221, PubMed:25474007, PubMed:23650379, PubMed:27906179, PubMed:31714929, PubMed:32047033), Protects against mitochondrial dysfunction during cellular stress, by acting downstream of Pink1, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:12642658, PubMed:15073152, PubMed:16672980, PubMed:16672981, PubMed:17123504, PubMed:18957282, PubMed:18799731, PubMed:18230723, PubMed:18443288, PubMed:20496123, PubMed:20194754, PubMed:23509287, PubMed:24192653, PubMed:24901221, PubMed:25474007, PubMed:27906179, PubMed:29497364, PubMed:32047033), Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:12642658, PubMed:15073152, PubMed:16002472, PubMed:16672980, PubMed:16672981, PubMed:17123504, PubMed:18957282, PubMed:18799731, PubMed:18230723, PubMed:18443288, PubMed:20496123, PubMed:20194754, PubMed:23509287, PubMed:24192653, PubMed:24901221, PubMed:25474007, PubMed:27906179, PubMed:29497364, PubMed:32047033), Appears to be particularly important in maintaining the physiology and function of cells with high energy demands that are undergoing stress or altered metabolic environment, including spermatids, muscle cells and neurons such as the dopaminergic (DA) neurons (PubMed:12642658, PubMed:15073152, PubMed:16002472, PubMed:16672980, PubMed:17123504, PubMed:18799731, PubMed:20483372, PubMed:22396657, PubMed:24901221, PubMed:28435104, PubMed:29497364, PubMed:31714929), Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires Pink1-mediated phosphorylation of both park and ubiquitin (PubMed:18957282, PubMed:24901221, PubMed:20194754, PubMed:22396657, PubMed:18799731, PubMed:18230723, PubMed:25474007, PubMed:27906179), In depolarized mitochondria, mediates the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of porin/VDAC; polyubiquitination of porin promotes mitophagy, while monoubiquitination of porin decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033), When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins (PubMed:16672980, PubMed:16672981, PubMed:20194754, PubMed:18957282, PubMed:23509287, PubMed:24192653, PubMed:25474007, PubMed:29497364), Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy (PubMed:32047033, PubMed:23650379), In developing tissues, inhibits JNK-mediated apoptosis by negatively regulating bsk transcription (PubMed:16002472, PubMed:20496123), The Pink1-park pathway also promotes fission and/or inhibits fusion of damaged mitochondria by mediating the ubiquitination and subsequent degradation of proteins involved in mitochondrial fusion/fission such as Marf, Opa1 and fzo (PubMed:18443288, PubMed:17123504, PubMed:18799731, PubMed:18230723, PubMed:20194754, PubMed:23650379, PubMed:24192653, PubMed:24901221, PubMed:29497364), This prevents the refusion of unhealthy mitochondria with the healthy mitochondrial network and/or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:17123504, PubMed:18799731, PubMed:18230723, PubMed:20194754, PubMed:23650379, PubMed:24192653, PubMed:24901221, PubMed:29497364), Regulates motility of damaged mitochondria by phosphorylating Miro which likely promotes its park-dependent degradation by the proteasome; in motor neurons, this inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria being eliminated in the soma (PubMed:22396657), The Pink1-park pathway is also involved in mitochondrial regeneration processes such as promoting mitochondrial biogenesis, activating localized mitochondrial repair, promoting selective turnover of mitochondrial proteins and initiating the mitochondrial import of endogenous proteins (PubMed:16672980, PubMed:20496123, PubMed:20869429, PubMed:23509287, PubMed:23650379, PubMed:24192653, PubMed:25565208, PubMed:29497364), Involved in mitochondrial biogenesis via the ubiquitination of transcriptional repressor Paris which leads to its subsequent proteasomal degradation and allows activation of the transcription factor srl (PubMed:23509287, PubMed:29497364, PubMed:32138754), Promotes localized mitochondrial repair by activating the translation of specific nuclear-encoded mitochondrial RNAs (nc-mtRNAs) on the mitochondrial surface, including several key electron transport chain component nc-mtRNAs (PubMed:23509287, PubMed:25565208)

Belongs to the RBR family, Parkin subfamily


This is Butyrophilin subfamily 2 member A1 protein, from Human, contains 527 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Zinc finger protein 765 protein, from Human, contains 523 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 8 C2H2-type Zinc finger, has 1 C2H2-type 8; atypical Zinc finger, has 1 C2H2-type 11; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 8; atypical

C2H2-type 11; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Fc receptor-like A protein, from Human, contains 359 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be implicated in B-cell differentiation and lymphomagenesis


This is E3 ubiquitin-protein transferase MAEA protein, from Human, contains 396 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972), MAEA is required for normal cell proliferation (PubMed:29911972), The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972), Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity), Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581), Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis, Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity), May contribute to nuclear architecture and cells division events (Probable)


This is G2/M phase-specific E3 ubiquitin-protein ligase protein, from Human, contains 706 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 2 PHD-type Zinc finger, has 1 PHD-type 2; degenerate Zinc finger.

C2HC pre-PHD-type

PHD-type

PHD-type 2; degenerate

PHD-type

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Essential in early embryonic development to prevent apoptotic death


This is RAS guanyl-releasing protein 2 protein, from Human, contains 609 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP, May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS, Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation, May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway


This is CXXC-type zinc finger protein 5 protein, from Human, contains 322 amino acids, has 1 CXXC-type Zinc finger.

CXXC-type

May indirectly participate in activation of the NF-kappa-B and MAPK pathways, Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity), Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest, Involved in myelopoiesis, Transcription factor, Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788), May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788), Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034)


This is Protein kinase C beta type protein, from African clawed frog, contains 671 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation, Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival, Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling, Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates isoform p66Shc of shc1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer, Acts as a coactivator of androgen receptor (andr)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Transcription factor castor protein, from Fruit fly, contains 793 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

Transcription factor that specifies expression of key genes in developing central nervous system (CNS), Essential for many, if not all, late developing neuroblastoma (NB) sublineages, Binds to the 5'-[CG]C[CT][CT]AAAAA[AT]-3' DNA sequence, like hb, suggesting that cas and hb act as a late regulators in early and late CNS NB sublineage, respectively, Acts by repressing expression of nub/pdm-1 and pdm2/pdm-2 POU genes, and restrict their pattern of expression in appropriate cells, Required for a full expression of vvl/drifter and acj6/I-POU; it is however unknown whether it directly activates these genes, Controls engrailed (en) expression in the ventral nerve chord


This is N-lysine methyltransferase SMYD2 protein, from Rat, contains 433 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Sodium channel subunit beta-4 protein, from Mouse, contains 228 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Modulates channel gating kinetics, Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation, Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity)

Belongs to the sodium channel auxiliary subunit SCN4B (TC 8,A,17) family


This is Sodium channel subunit beta-4 protein, from Rat, contains 228 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Modulates channel gating kinetics, Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation, Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom


This is Ubiquitin thioesterase Zranb1 protein, from Mouse, contains 708 amino acids, has 3 RanBP2-type Zinc finger.

Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity), Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity), Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (By similarity), Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (By similarity), Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity), Required in the stress fiber dynamics and cell migration (By similarity)


This is Histone acetyltransferase esa-1 protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 506 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


This is Protein kinase C beta type protein, from Zebrafish, contains 670 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type


This is E3 ubiquitin-protein ligase Siah2 protein, from Zebrafish, contains 331 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, It probably triggers the ubiquitin-mediated degradation of different substrates, Induces cellular growth arrest by inhibiting the G2/M transition (PubMed:15055544), May play a role in the regulation of the cellular clock function (By similarity)

Belongs to the SINA (Seven in absentia) family


This is Retinoic acid receptor RXR-beta-A protein, from Zebrafish, contains 471 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Cilium assembly protein DZIP1 protein, from Zebrafish, contains 898 amino acids, has 1 C2H2-type Zinc finger.

Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:19852954), Required for establishment of left-right asymmetry during embryogenesis (PubMed:19852954), Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals (PubMed:15115751), Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo (PubMed:15198976)

Belongs to the DZIP C2H2-type zinc-finger protein family


This is Androgen receptor protein, from American bullfrog, contains 777 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcription factor activity is modulated by bound coactivator and corepressor proteins

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is E3 ubiquitin-protein ligase rnf168 protein, from Zebrafish, contains 474 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage, Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination, Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates, This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of tp53bp1 and brca1, Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)


This is Zinc finger C4H2 domain-containing protein protein, from Zebrafish, contains 224 amino acids, has 1 C4H2-type Zinc finger.

Plays a role in GABAergic and V2 interneurons differentiation (PubMed:26056227), Involved in motoneuron development and in neuromuscular junction formation (PubMed:23623388)


This is Zygote arrest protein 1 protein, from Zebrafish, contains 329 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:27913641), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of zona pellucida mRNAs, inhibiting their translation (PubMed:27913641)

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is E3 ubiquitin-protein ligase UHRF2 protein, from Mouse, contains 803 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair, Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:23434322, PubMed:28402695), This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (PubMed:28115522), Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thus inducing G1 arrest, Ubiquitinates also PCNP leading to its degradation by the proteasome, Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation, Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor, Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation, Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (By similarity)


This is E3 ubiquitin-protein ligase RNF139 protein, from Mouse, contains 668 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death, Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER), Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression, Involved in the sterol-accelerated degradation of HMGCR, This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane, In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR, The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction, Required for INSIG1 ubiquitination, May be required for EIF3 complex ubiquitination


This is Stromal membrane-associated protein 2 protein, from Mouse, contains 428 amino acids, has 1 C4-type Zinc finger.

GTPase activating protein that acts on ARF1, Can also activate ARF6 (in vitro), May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network


This is Retrotransposon-derived protein PEG10 protein, from Mouse, contains 958 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:30951545, PubMed:34413232), Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232), Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232), Involved in placenta formation: required for trophoblast stem cells differentiation (PubMed:16341224, PubMed:30951545), Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377), Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity), Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity), May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (PubMed:9473521)


This is Amphoterin-induced protein 2 protein, from Rat, contains 520 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Required for depolarization-dependent survival of cultured cerebellar granule neurons, May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3, May contribute to signal transduction through its intracellular domain

Belongs to the immunoglobulin superfamily, AMIGO family


This is Tripartite motif-containing protein 46 protein, from Mouse, contains 759 amino acids, has 1 RING-type 1; degenerate Zinc finger, has 1 RING-type 2; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type 1; degenerate

RING-type 2; degenerate

B box-type

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon, Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons, Thereby also required for proper axon formation, the establishment of neuronal polarity and proper neuronal migration


This is Immunoglobulin superfamily member 21 protein, from Mouse, contains 468 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Involved in synaptic inhibition in the brain, Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2


This is Rab effector MyRIP protein, from Rat, contains 856 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab effector protein involved in melanosome transport, Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A, May link RAB27A-containing vesicles to actin filaments (By similarity), Functions as a protein kinase A-anchoring protein (AKAP), May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release


This is CD276 antigen protein, from Rat, contains 316 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection, May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface, Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells (By similarity)


This is F-box only protein 11 protein, from Mouse, contains 930 amino acids, has 1 UBR-type Zinc finger.

UBR-type

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1, The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells, The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit, Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity, SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53


This is E3 ubiquitin-protein ligase UHRF1 protein, from Rat, contains 774 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification, Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication, In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins, Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication, Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications, Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML, It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo, Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation (By similarity)


This is E3 ubiquitin-protein ligase TRIM17 protein, from Mouse, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:20559321, PubMed:22976837, PubMed:25215946), Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation, Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies, Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity), Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death (PubMed:22976837), In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities (PubMed:25215946), Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (PubMed:30485814), Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity)


This is Zinc finger protein ZIC 5 protein, from Mouse, contains 622 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate, Binds to DNA

Belongs to the GLI C2H2-type zinc-finger protein family


This is Endoplasmic reticulum junction formation protein lunapark protein, from Mouse, contains 425 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology, Involved in the stabilization of nascent three-way ER tubular junctions within the ER network, May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network, May be involved in limb and central nervous system development (PubMed:12732147)


This is Aprataxin protein, from Mouse, contains 342 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair, Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species, Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241), Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity), Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)


This is WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 protein, from Mouse, contains 571 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease-inhibitor that contains multiple distinct protease inhibitor domains, Probably has serine protease- and metalloprotease-inhibitor activity (By similarity), Inhibits the biological activity of mature myostatin, but not activin