This is E3 ubiquitin-protein ligase BRE1-like 1 protein, from Mouse-ear cress, contains 878 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1, H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me, It thereby plays a central role in histone code and gene regulation, Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6, Required for the regulation of flowering time and defense against necrotrophic fungal pathogens (PubMed:12535538, PubMed:17329565, PubMed:17329563, PubMed:19286969), Involved in the control of seed dormancy and germination (PubMed:21799800)


This is E3 ubiquitin-protein ligase ATL6 protein, from Mouse-ear cress, contains 398 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro, May be involved in the plant C/N response and the early steps of the plant defense signaling pathway

Belongs to the RING-type zinc finger family, ATL subfamily


This is E3 ubiquitin-protein ligase SINAT5 protein, from Mouse-ear cress, contains 309 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12226665), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:12226665), Mediates the ubiquitination and proteasomal-dependent degradation of NAC021/NAC022, a transcription activator that functions downstream of the auxin signals, thereby acting as a down-regulator of auxin signals (PubMed:12226665), Involved in the formation of lateral roots (PubMed:12226665), Is antagonist to SINAT1, SINAT2, SINAT3 and SINAT4 by suppressing FREE1 ubiquitination and degradation mediated by SINAT1, SINAT2, SINAT3 and SINAT4, and promoting FREE1 accumulation (PubMed:32786047)

Belongs to the SINA (Seven in absentia) family


This is Squamosa promoter-binding-like protein 7 protein, from Mouse-ear cress, contains 801 amino acids, has 1 SBP-type; atypical Zinc finger.

SBP-type; atypical

Transcription factor that participates in reprogramming global gene expression during copper deficiency in order to improve the metal uptake and prioritize its distribution to copper proteins of major importance (Probable), Binds directly to 5'-GTAC-3' motifs in the microRNA (miRNA) promoter of the stress-responsive miRNAs miR398b and miR398c to activate their transcription, During copper deficiency, activates the copper transporters COPT1 and COPT2, and the copper chaperone CCH, directly or indirectly via miRNAs, Required for the expression of the miRNAs miR397, miR408 and miR857 (PubMed:19122104), Acts coordinately with HY5 to regulate miR408 and its target genes in response to changes in light and copper conditions (PubMed:25516599), Activates miR857 and its target genes in response to low copper conditions (PubMed:26511915), Involved in cadmium stress response by regulating miR397a, miR398b, miR398c and miR857 (PubMed:27352843), Required for iron homeostasis during copper deficiency (PubMed:22374396)


This is Zinc finger protein VAR3, chloroplastic protein, from Mouse-ear cress, contains 758 amino acids, has 2 RanBP2-type Zinc finger.

Probable component of some protein complex required for chloroplast and palisade cell development (PubMed:15340011), Involved in C-to-U editing of chloroplastic RNA, Controls a large number of chloroplastic editing sites, Binds the editing recognition trans-factors PCMP-H51/CRR28 and PCMP-H12/OTP82 (PubMed:25768119)


This is Polycomb protein PHO protein, from Fruit fly, contains 520 amino acids, has 4 C2H2-type Zinc finger.

Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is Gametocyte-specific factor 1 homolog protein, from Fruit fly, contains 167 amino acids, has 2 CHHC U11-48K-type Zinc finger.

CHHC U11-48K-type

CHHC U11-48K-type

Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons, Required for repression of transposons and neighboring genes in ovarian somatic and germline cells


This is Probable E3 ubiquitin-protein ligase sinah protein, from Fruit fly, contains 351 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, The adapter phyl is required to direct the degradation of the two isoforms of the transcriptional repressor Tramtrack (Ttk), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, It probably triggers the ubiquitin-mediated degradation of different substrates, A phyl-independent mechanism of degradation exists for isoform beta of ttk that involves motifs in the C-terminus of ttk


This is CCHC-type zinc finger nucleic acid binding protein protein, from Fruit fly, contains 165 amino acids, has 6 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Single-stranded DNA/RNA-binding protein with sequence specificity (By similarity), Binds G-rich elements in target mRNA coding sequences (By similarity), Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity), IRES trans-acting factor (ITAF) that can promote IRES-dependent translation of Myc mRNA (PubMed:24275942), Involved in the control of wing size by regulating Myc levels (PubMed:24275942)


This is Retinitis pigmentosa 9 protein protein, from Human, contains 221 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Is thought to be a target protein for the PIM1 kinase, May play some roles in B-cell proliferation in association with PIM1 (By similarity)


This is V-set and transmembrane domain-containing protein 2A protein, from Human, contains 236 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation, Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway


This is Endonuclease 8-like 3 protein, from Human, contains 605 amino acids, has 1 FPG-type Zinc finger, has 1 RanBP2-type Zinc finger, has 2 GRF-type Zinc finger.

FPG-type

GRF-type

GRF-type

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964), Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity), In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964), No activity on 8-oxoG detected (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964), Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964), In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964)


This is Nuclear protein localization protein 4 homolog protein, from Human, contains 608 amino acids, has 1 RanBP2-type Zinc finger.

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome, The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity), Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729)


This is Zinc finger protein 417 protein, from Human, contains 575 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 5; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Protein odd-skipped-related 1 protein, from Human, contains 266 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development

Belongs to the Odd C2H2-type zinc-finger protein family


This is THAP domain-containing protein 6 protein, from Human, contains 222 amino acids, has 1 THAP-type Zinc finger.

THAP-type


This is E3 ubiquitin-protein ligase LNX protein, from Human, contains 728 amino acids, has 1 RING-type Zinc finger.

RING-type

Isoform 2 provides an endocytic scaffold for IGSF5/JAM4


This is Zinc finger and SCAN domain-containing protein 18 protein, from Human, contains 510 amino acids, has 2 C2H2-type Zinc finger.


This is Fez family zinc finger protein 2 protein, from Human, contains 459 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor, Required for the specification of corticospinal motor neurons and other subcerebral projection neurons, May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation, Controls the development of dendritic arborization and spines of large layer V pyramidal neurons, May be involved in innate immunity (By similarity)


This is Zinc finger CCHC domain-containing protein 10 protein, from Human, contains 192 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Zinc finger protein 564 protein, from Human, contains 553 amino acids, has 15 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase RNF217 protein, from Human, contains 542 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis

Belongs to the RBR family, RNF217 subfamily


This is AN1-type zinc finger protein 1 protein, from Human, contains 268 amino acids, has 2 AN1-type Zinc finger.

Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover, SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830), Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830), This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830)


This is E3 ubiquitin-protein ligase MARCHF1 protein, from Human, contains 289 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system

Golgi apparatus, trans-Golgi network membrane


This is Zinc finger protein 398 protein, from Human, contains 642 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 7 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; degenerate

Functions as a transcriptional activator


This is Zinc finger protein 675 protein, from Human, contains 568 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger, has 11 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 3; degenerate

C2H2-type 4; degenerate

May be involved in transcriptional regulation, May play a role during osteoclast differentiation by modulating TRAF6 signaling activity


This is Cell surface glycoprotein CD200 receptor 1 protein, from Human, contains 348 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein, Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli, Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200


This is E3 ubiquitin-protein ligase DTX3L protein, from Human, contains 740 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272), Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742), In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714), The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714), PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272), By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788), Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097), In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097), In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788)


This is Transcription factor Sp7 protein, from Human, contains 431 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional activator essential for osteoblast differentiation (PubMed:23457570), Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is RAS guanyl-releasing protein 4 protein, from Human, contains 673 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP, May function in mast cells differentiation


This is Hepatitis A virus cellular receptor 2 protein, from Human, contains 301 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor implicated in modulating innate and adaptive immune responses, Generally accepted to have an inhibiting function, Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777), Regulates macrophage activation (PubMed:11823861), Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005), In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion, The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563), In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity), Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857), Receptor for LGALS9 (PubMed:16286920, PubMed:24337741), Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6, Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens, Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity), However, the function as receptor for LGALS9 has been challenged (PubMed:23555261), Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity), Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent, May recognize PtSer on apoptotic cells leading to their phagocytosis, Mediates the engulfment of apoptotic cells by dendritic cells, Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells, Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha, In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity), Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453), In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801), Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity)

Belongs to the immunoglobulin superfamily, TIM family


This is CMRF35-like molecule 1 protein, from Human, contains 290 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731), Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells, Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity), Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150), May act as a coreceptor for interleukin 4 (IL-4), Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity), Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923), Inhibits osteoclast formation, Induces macrophage cell death upon engagement (By similarity)


This is Synaptotagmin-like protein 5 protein, from Human, contains 730 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May act as Rab effector protein and play a role in vesicle trafficking, Binds phospholipids


This is Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 protein, from Human, contains 903 amino acids, has 1 C4-type Zinc finger.


This is OTU domain-containing protein 7A protein, from Human, contains 926 amino acids, has 1 A20-type Zinc finger.

Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains


This is MORC family CW-type zinc finger protein 4 protein, from Human, contains 937 amino acids, has 1 CW-type Zinc finger.

CW-type

Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034), The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034)


This is E3 ubiquitin-protein ligase RNF128 protein, from Human, contains 428 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation, Functions as an inhibitor of cytokine gene transcription, Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production, Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse, Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals


This is E3 ubiquitin-protein ligase SH3RF2 protein, from Human, contains 729 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity (PubMed:24130170), Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169), Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170), Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623)


This is E3 ubiquitin-protein ligase SH3RF3 protein, from Human, contains 882 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity


This is WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 protein, from Human, contains 576 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease-inhibitor that contains multiple distinct protease inhibitor domains, Probably has serine protease- and metalloprotease-inhibitor activity, Inhibits the biological activity of mature myostatin, but not activin (By similarity)


This is Ubiquitin carboxyl-terminal hydrolase 33 protein, from Human, contains 942 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling, Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate, Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling, Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2), Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2, Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2, This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins, Deubiquitinates DIO2, thereby regulating thyroid hormone regulation, Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Belongs to the peptidase C19 family, USP20/USP33 subfamily


This is Zinc finger protein 90 homolog protein, from Human, contains 636 amino acids, has 13 C2H2-type Zinc finger.

Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg)


This is Zinc finger protein 526 protein, from Human, contains 670 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Transcriptional regulator Kaiso protein, from African clawed frog, contains 701 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator with bimodal DNA-binding specificity, Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3', May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters, Contributes to the repression of target genes of the Wnt signaling pathway and to the methylation-dependent repression of zygotic transcription prior to the mid-blastula transition (MBT), Also required for gastrulation movements


This is Osteoclast-associated immunoglobulin-like receptor protein, from Mouse, contains 265 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation

Belongs to the leukocyte receptor complex/polymeric immunoglobulin receptor (PIR/LRC) family


This is Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2 protein, from Mouse, contains 614 amino acids, has 1 RTR1-type Zinc finger.

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes, Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity), Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:35975910)


This is E3 ubiquitin-protein ligase RNF8 protein, from Mouse, contains 488 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites, Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF), Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites, Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases, For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains, Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5, Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites, Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta, In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity, In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation, Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase, Required in the testis, where it plays a role in the replacement of histones during spermatogenesis (PubMed:20153262, PubMed:28552346), At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis, Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis, May play a role in the regulation of RXRA-mediated transcriptional activity, Not involved in RXRA ubiquitination by UBE2E2


This is CMRF35-like molecule 5 protein, from Mouse, contains 221 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

(Microbial infection) Acts as a functional murine norovirus (MNV) receptor, Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV, Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27681626, PubMed:27540007)


This is Mitochondrial ubiquitin ligase activator of NFKB 1 protein, from Mouse, contains 352 amino acids, has 1 RING-type Zinc finger.

RING-type

Exhibits weak E3 ubiquitin-protein ligase activity (By similarity), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity), Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation (By similarity), Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-27' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (By similarity), Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (By similarity), Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (By similarity), Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855), May also be involved in the sumoylation of the membrane fission protein DNM1L (By similarity), Inhibits cell growth (By similarity), When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (By similarity), Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (By similarity), Can mediate RIGI sumoylation and disrupt its polyubiquitination (By similarity)


This is Zinc finger protein 385A protein, from Mouse, contains 386 amino acids, has 3 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

RNA-binding protein that affects the localization and the translation of a subset of mRNA, May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation, Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation, With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A, Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity, May also bind CCNB1 mRNA, Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction, Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes, May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest, Also plays a role in megakaryocytes differentiation


This is E3 ubiquitin-protein ligase UHRF1 protein, from Mouse, contains 782 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification, Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication, In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins, Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication, Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications, Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML, It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo, Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation ()


This is Zinc finger protein GLIS2 protein, from Mouse, contains 521 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context, Acts as a repressor of the Hedgehog signaling pathway, Represses the Hedgehog-dependent expression of Wnt4, Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition, Represses transcriptional activation by CTNNB1 in the Wnt signaling pathway, May act by recruiting the corepressors CTBP1 and HDAC3, May be involved in neuron differentiation

Belongs to the GLI C2H2-type zinc-finger protein family


This is RNA-binding protein 4B protein, from Mouse, contains 357 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for the translational activation of PER1 mRNA in response to circadian clock, Binds directly to the 3'-UTR of the PER1 mRNA


This is CD276 antigen protein, from Mouse, contains 316 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection, Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface, Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Inhibitor of growth protein 3 protein, from Mouse, contains 421 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair, NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage, Component of a SWR1-like complex that specifically mediates the removal of histone H2A,Z/H2AZ1 from the nucleosome (By similarity)


This is E3 ubiquitin-protein ligase RNF130 protein, from Mouse, contains 419 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E3 ubiquitin-protein ligase (By similarity), May have a role during the programmed cell death of hematopoietic cells


This is Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 protein, from Mouse, contains 910 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for the ADP ribosylation factor family (Potential), GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway

Belongs to the centaurin gamma-like family


This is Synaptotagmin-like protein 4 protein, from Rat, contains 672 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary, Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity)


This is Transcriptional repressor p66-beta protein, from Mouse, contains 594 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional repressor, Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin, Enhances MBD2-mediated repression, Efficient repression requires the presence of GATAD2A, Targets MBD3 to discrete loci in the nucleus, May play a role in synapse development


This is Transcription factor Sp7 protein, from Mouse, contains 428 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional activator essential for osteoblast differentiation (PubMed:11792318, PubMed:17510056, PubMed:30026585), Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (PubMed:11792318, PubMed:17510056)


This is E3 ubiquitin-protein ligase TRAIP protein, from Mouse, contains 470 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:33590678), Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity), During mitosis, controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (PubMed:33590678), Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity), If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity), Only catalyzes ubiquitination of MCM7 when forks converge (By similarity), Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity), Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (By similarity), The function in translesion synthesis is however controversial (By similarity), Acts as a regulator of the spindle assembly checkpoint (By similarity), Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:17544371, PubMed:22945920), Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity)


This is Mineralocorticoid receptor protein, from Mouse, contains 978 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol, Binds to mineralocorticoid response elements (MRE) and transactivates target genes, The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Hepatitis A virus cellular receptor 2 homolog protein, from Mouse, contains 281 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor implicated in modulating innate and adaptive immune responses, Generally accepted to have an inhibiting function, Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:18006747), Regulates macrophage activation (PubMed:11823861), Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556006, PubMed:18006747), In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion, The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits (By similarity), In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (PubMed:21807895), Expressed on Treg cells can inhibit Th17 cell responses (By similarity), Receptor for LGALS9, Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6 (PubMed:22863785), Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens, Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (PubMed:20937702), However, the function as receptor for LGALS9 has been challenged (By similarity), Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (PubMed:24567532), Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent (PubMed:20083673), May recognize PtSer on apoptotic cells leading to their phagocytosis, Mediates the engulfment of apoptotic cells by dendritic cells (PubMed:19224762), Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells (PubMed:20083673), Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha (PubMed:18006747), In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (PubMed:22842346), Can enhance mast cell production of Th2 cytokines Il-4, IL-6 and IL-13 (PubMed:17620455), Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9, In contrast, shown to suppress NK cell-mediated cytotoxicity (By similarity), Negatively regulates NK cell function in LPS-induced endotoxic shock (PubMed:25337993)


This is Protein TRANSPARENT TESTA 1 protein, from Mouse-ear cress, contains 303 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

C2H2-type 4; atypical

May act as a transcriptional regulator involved in the differentiation of young endothelium, Altered differentiation results in incompetence for pigments synthesis and the lack of condensed tannins in the seed coat (PubMed:21477081), Plays a role in the regulatory network controlling flavonoid accumulation in endothelium cells during seed development (PubMed:21477081)

Belongs to the WIP C2H2-type zinc-finger protein family


This is SWI/SNF complex subunit SWI3D protein, from Mouse-ear cress, contains 985 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Component of a multiprotein complex equivalent of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors


This is Serine/arginine-rich splicing factor RS2Z33 protein, from Mouse-ear cress, contains 290 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Splicing factor involved in constitutive and/or alternative splicing, Regulates the splicing of its own pre-mRNA and the alternative splicing of RS30, RS31 and RS34, Associates the cyclin-dependent kinase G1 (CDKG1) with the spliceosome and recruits it to U1 snRNP to facilitate splicing

Belongs to the splicing factor SR family, RS2Z subfamily


This is Lysine-specific demethylase JMJ27 protein, from Mouse-ear cress, contains 840 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me1 and H3K9me2 (PubMed:28650521, PubMed:34197643), No activity on H3K4, H3K27, H3K36, H3R2 and H4R3 methyl marks, but weak activity on H3K9me3 (PubMed:28650521, PubMed:34197643), Involved in regulation of gene expression (PubMed:28650521), Regulates flowering time by repressing the major flowering regulator CONSTANS (CO) and promoting FLOWERING LOCUS C (FLC) (PubMed:28650521), Exhibits a positive impact on abscisic acid- (ABA), hydrogen peroxide- (H(2)O(2)) and calcium- (Ca(2+)) induced stomatal closure (PubMed:34197643), Promotes stomatal-closure-dependent drought-stress responses through its histone demethylase activity toward at least GOLS2 and RD20 loci, thus protecting them from silencing by removing H3K9me2 marks in drought conditions (PubMed:34197643), Required for plant defenses leading to resistance against the virulent bacterial pathogen Pseudomonas syringae pv, tomato DC3000 (Pst DC3000) via a negative regulation of WRKY25 (a repressor of defense) and by triggering the expression of several pathogenesis-related (PR) proteins (e,g, PR1, PR3, PR4 and PR5) (PubMed:28650521)

Belongs to the JARID1 histone demethylase family


This is E3 ubiquitin protein ligase RIN2 protein, from Mouse-ear cress, contains 578 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN3, Probably not required for RPM1 degradation during HR


This is E3 ubiquitin-protein ligase ORTHRUS 2 protein, from Mouse-ear cress, contains 645 amino acids, has 1 PHD-type Zinc finger, has 2 RING-type Zinc finger.

PHD-type

RING-type

RING-type

E3 ubiquitin-protein ligase, Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing, Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11, Promotes methylation-mediated gene silencing leading, for example, to early flowering, Associates with methylated DNA, and can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate, Probably acts at the DNA methylation?histone interface to maintain centromeric heterochromatin


This is Histone-lysine N-methyltransferase ATXR5 protein, from Mouse-ear cress, contains 379 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone methyltransferase that specifically monomethylates 'Lys-27' of histone H3 (H3K27me1), Has much higher activity on nucleosomes containing H3,1 than H3,3, Involved in the formation of constitutive heterochromatin and the silencing of heterochromatic elements, Influences which sets of rRNA gene variants are expressed or silenced

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily


This is E3 ubiquitin-protein ligase MIEL1 protein, from Mouse-ear cress, contains 267 amino acids, has 1 CHY-type Zinc finger, has 1 CTCHY-type Zinc finger, has 1 RING-type; atypical Zinc finger.

CHY-type

CTCHY-type

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a regulator of cell death and defense, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Attenuates the activation of defense and related cell death responses in the absence of pathogens by mediating ubiquitination and subsequent proteasomal degradation of MYB30


This is Cyclic dof factor 1 protein, from Mouse-ear cress, contains 298 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence, A flanking TGT sequence contributes to the specificity of binding, Regulates a photoperiodic flowering response, Transcriptional repressor of 'CONSTANS' expression, The DNA-binding ability is not modulated by 'GIGANTEA' but the stability of CDF1 is controlled by the proteasome-dependent pathway, Ubiquitinated by the SCF(ADO3) E3 ubiquitin ligase complex, Binds to the FT promoter in the morning


This is Probable E3 ubiquitin-protein ligase ARI8 protein, from Mouse-ear cress, contains 567 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger, has 1 RanBP2-type Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates

Belongs to the RBR family, Ariadne subfamily


This is B3 domain-containing transcription repressor VAL1 protein, from Mouse-ear cress, contains 790 amino acids, has 1 CW-type Zinc finger.

CW-type

Transcriptional repressor of gene expression involved in embryonic pathways, such as LEC1, ABI3, and FUS3, Repressor of the sugar-inducible genes involved in the seed maturation program in seedlings, Plays an essential role in regulating the transition from seed maturation to seedling growth, Functionally redundant with VAL2/HSL1


This is E3 ubiquitin protein ligase RIN3 protein, from Mouse-ear cress, contains 577 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN2, Probably not required for RPM1 degradation during HR


This is Polycomb group protein VERNALIZATION 2 protein, from Mouse-ear cress, contains 440 amino acids, has 1 C2H2-type Zinc finger.

Polycomb group (PcG) protein, Plays a central role in vernalization by maintaining repressed the homeotic gene FLC, a floral repressor, after a cold treatment, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility, Associates constitutively along the whole FLC locus

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is Coxsackievirus and adenovirus receptor homolog protein, from Bovine, contains 365 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity, Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes, The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair, Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases, It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair (By similarity)


This is Terminal uridylyltransferase 1 protein, from Trypanosoma brucei brucei, contains 976 amino acids, has 1 C2H2-type; atypical Zinc finger.

C2H2-type; atypical

Terminal uridylyltransferase which is involved in the post-transcriptional editing of mitochondrial RNA, a process involving the addition and deletion of uridine (U) nucleotides in the pre-RNA (PubMed:11893335, PubMed:20086102, PubMed:26833087, PubMed:27744351), Specifically, catalyzes the addition of Us to the 3'-hydroxyl group of guided RNA (gRNA), ribosomal RNA (rRNA) and some mRNAs (PubMed:11893335, PubMed:20086102, PubMed:26833087, PubMed:27744351), As part of the mitochondrial 3' processome (MPsome), catalyzes the primary 3' uridylation of gRNA precursors to facilitate their recognition and to induce their processive 3'-5' degradation by DSS1, and the secondary 3' uridylation of mature gRNAs (PubMed:26833087), Involved in the 3' uridylylation of the long A/U tail of some edited and never-edited mRNAs (PubMed:20086102), Promotes 3' uridylylation-mediated decay of some never-edited mRNAs (PubMed:20086102), Does not mediate RNA-independent UTP polymerization (PubMed:27744351)

Belongs to the DNA polymerase type-B-like family


This is Zinc finger protein 473 protein, from Human, contains 871 amino acids, has 18 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 6; degenerate

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex, Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed, Required for cell cycle progression from G1 to S phases

Belongs to the krueppel C2H2-type zinc-finger protein family


This is THAP domain-containing protein 3 protein, from Human, contains 239 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1


This is E3 ubiquitin-protein ligase RNF139 protein, from Human, contains 664 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439), Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873), Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067), Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569), This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767), In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569), The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569), Required for INSIG1 ubiquitination (PubMed:20068067), May be required for EIF3 complex ubiquitination (PubMed:20068067)


This is Splicing factor U2AF 26 kDa subunit protein, from Human, contains 220 amino acids, has 2 C3H1-type Zinc finger.

RNA-binding protein that function as a pre-mRNA splicing factor, Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection, Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts, Also participates in the regulation of alternative pre-mRNA splicing, Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1, Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity), Shows a preference for AGC or AGA (By similarity)

Belongs to the splicing factor SR family


This is Stromal membrane-associated protein 2 protein, from Human, contains 429 amino acids, has 1 C4-type Zinc finger.

GTPase activating protein that acts on ARF1, Can also activate ARF6 (in vitro), May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity)


This is Zinc finger CCCH domain-containing protein 15 protein, from Human, contains 426 amino acids, has 2 C3H1-type Zinc finger.

Protects DRG1 from proteolytic degradation (PubMed:19819225), Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155)


This is PHD finger protein 10 protein, from Human, contains 498 amino acids, has 1 PHD-type 1; degenerate Zinc finger, has 1 PHD-type 2; degenerate Zinc finger.

PHD-type 1; degenerate

PHD-type 2; degenerate

Involved in transcription activity regulation by chromatin remodeling, Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors, During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)


This is Zinc finger protein 296 protein, from Human, contains 475 amino acids, has 6 C2H2-type Zinc finger.

May be a transcriptional corepressor with KLF4


This is GATA zinc finger domain-containing protein 1 protein, from Human, contains 269 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3)


This is Non-structural maintenance of chromosomes element 1 homolog protein, from Human, contains 266 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate, Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex, Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:29225034, PubMed:20864041), NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888), MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery, Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors (PubMed:29225034)


This is E3 ubiquitin-protein ligase TRIM41 protein, from Human, contains 630 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type; degenerate

B box-type

E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016), Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:29899090, PubMed:31979016, PubMed:28169297), Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876), Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity), Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676)


This is AN1-type zinc finger protein 2B protein, from Human, contains 257 amino acids, has 2 AN1-type Zinc finger.

Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum, It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum, It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed, May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity), By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)


This is E3 ubiquitin-protein ligase RNF138 protein, from Human, contains 245 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger, has 2 C2H2-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057), Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057), Two different, non-exclusive, mechanisms have been proposed, According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055), According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057), Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285), Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285), May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285)


This is RING finger protein 141 protein, from Human, contains 230 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Butyrophilin subfamily 2 member A2 protein, from Human, contains 523 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion


This is DnaJ homolog subfamily A member 4 protein, from Human, contains 397 amino acids, has 1 CR-type Zinc finger.

CR-type


This is E3 ubiquitin-protein ligase ZNRF4 protein, from Human, contains 429 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (PubMed:28656966), Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830), Could have a role in spermatogenesis (By similarity)


This is High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor protein, from Human, contains 532 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Functions as a receptor for the Fc fragment of IgA and IgM, Binds IgA and IgM with high affinity and mediates their endocytosis, May function in the immune response to microbes mediated by IgA and IgM


This is Ras association domain-containing protein 5 protein, from Human, contains 418 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Potential tumor suppressor, Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation, Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1, Together with RAP1A may participate in regulation of microtubule growth, The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing, May be involved in regulation of Ras apoptotic function, The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis


This is RUN and FYVE domain-containing protein 2 protein, from Human, contains 606 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type


This is Transcriptional repressor p66-beta protein, from Human, contains 593 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional repressor (PubMed:12183469, PubMed:16415179), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666), Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179), Efficient repression requires the presence of GATAD2A (PubMed:16415179), Targets MBD3 to discrete loci in the nucleus (PubMed:11756549), May play a role in synapse development (PubMed:23644463)


This is Nanos homolog 1 protein, from Human, contains 292 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type

May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets, Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin, Up-regulates the production of MMP14 to promote tumor cell invasion


This is E3 ubiquitin-protein ligase MYLIP protein, from Human, contains 445 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8, Activity depends on E2 enzymes of the UBE2D family, Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth, Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR


This is Peroxynitrite isomerase THAP4 protein, from Human, contains 577 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate, Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively), Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region

In the C-terminal section; belongs to the nitrobindin family


This is Inhibitor of growth protein 5 protein, from Human, contains 240 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767), Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653), Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653), Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715)


This is E3 ubiquitin-protein ligase rififylin protein, from Human, contains 363 amino acids, has 1 FYVE-type Zinc finger, has 1 RING-type Zinc finger.

FYVE-type

RING-type

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins, Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex, Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis, Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation, Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation, Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN, May also play a role in endocytic recycling


This is Retinoic acid receptor alpha-A protein, from Zebrafish, contains 444 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), Required for hindbrain patterning

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Fibroblast growth factor receptor 4 protein, from Common quail, contains 713 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis, Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19, Phosphorylates PLCG1 and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Fibroblast growth factor receptor 4 protein, from Zebrafish, contains 922 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis, Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19, Phosphorylates PLCG1 and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)


This is Retinoic acid receptor RXR-alpha-B protein, from Zebrafish, contains 379 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid that acts as a transcription factor (PubMed:7565671), Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (By similarity), The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (By similarity), The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity), In the absence of ligand, the rar/rxr heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity), On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Retinoic acid receptor RXR-gamma-A protein, from Zebrafish, contains 441 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity)


This is Retinoic acid receptor RXR-beta-B protein, from Zebrafish, contains 422 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is CD166 antigen homolog A protein, from Zebrafish, contains 564 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts, Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity), Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity), Mediates homotypic interactions with cells that express ALCAM, Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction, Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions, Required for normal organization of the lymph vessel network, Required for normal hematopoietic stem cell engraftment in the bone marrow, Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow, Promotes in vitro osteoblast proliferation and differentiation (By similarity), Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity), Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)


This is Semaphorin-3A protein, from Chicken, contains 772 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Induces the collapse and paralysis of neuronal growth cones, Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism, Binds to neuropilin


This is COUP transcription factor 2 protein, from Chicken, contains 410 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity), May be involved in motor neuron development


This is Retinoic acid receptor alpha protein, from Chicken, contains 460 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), Required for hindbrain patterning and appears to be required for skin development


This is E3 ubiquitin-protein ligase RNF13 protein, from Chicken, contains 381 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:20015074), Involved in apoptosis regulation, Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity)


This is Transcription factor Sp3 protein, from Chicken, contains 771 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional factor that can act as an activator or repressor depending on post-translational modifications, Binds to GT and GC boxes promoter elements, Competes with SP1 for the GC-box promoters, Weak activator of transcription (By similarity), Required for activation of SPARC transcription

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Nanos homolog 3 protein, from Zebrafish, contains 159 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type

RNA-binding protein which binds to RNA with no sequence specificity (PubMed:20948543), Probably represses translation of specific mRNAs (By similarity), Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival but is not required for PGC specification (PubMed:11691838, PubMed:17418113), Also required to maintain oocyte production in the adult ovary (PubMed:17418113, PubMed:23228893), Negatively regulates phosphorylation of myosin mylpfa/mylz2 (PubMed:20673786)


This is Kruppel-like factor 1 protein, from Zebrafish, contains 365 amino acids, has 3 C2H2-type Zinc finger.

Transcription regulator (PubMed:18941117, PubMed:33833125), Plays a role in erythropoiesis, binding to promoters and activating transcription of embryonic alpha globin e1 hbae1,1 and microRNA mir-144, in erythroid progenitors; perhaps acting as part of a negative feedback loop with mir-144 (PubMed:33833125, PubMed:18941117), May coordinate repression of genes controlling myocardial differentiation and mitochondrial metabolism with positive modulation of cell proliferation genes (PubMed:33833125), Required for regeneration of the myocardium after injury, probably acting by stimulating renewal of preexisting cardiomyocytes in adult hearts (PubMed:33833125)


This is Protein kinase C iota type protein, from Zebrafish, contains 588 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity), Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Fibroblast growth factor receptor 1-A protein, from Zebrafish, contains 810 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration, Required for normal mesoderm patterning and normal skeletogenesis, Phosphorylates PLCG1, FRS2, GAB1 and SHB, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2, In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription, FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity)


This is Optineurin protein, from Chicken, contains 556 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, May act by regulating membrane trafficking and cellular morphogenesis, May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family


This is F-box only protein 5-A protein, from African clawed frog, contains 392 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC) (PubMed:15314241), Binds to the APC activator cdc20 to prevent APC activation (PubMed:11389834), Can also bind directly to the APC to inhibit substrate-binding (PubMed:11751633), Required to arrest unfertilized eggs at metaphase of meiosis II, by preventing their release from metaphase of meiosis II, through inhibition of APC-dependent cyclin B destruction leading to stabilization of cyclin B-cdk1 complex activity (PubMed:11976684)


This is Zinc finger protein 703 protein, from Zebrafish, contains 589 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters, Required for segmental gene expression during hindbrain development, May regulate cell adhesion, migration and proliferation


This is High affinity nerve growth factor receptor protein, from Chicken, contains 778 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons, High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3, Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation, Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signaling cascades driving cell survival and differentiation, In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is NT-3 growth factor receptor protein, from Chicken, contains 827 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in nervous system and probably heart development, Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity), The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival, Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells (PubMed:8060621)


This is Fibroblast growth factor receptor 2 protein, from Eastern newt, contains 729 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development, Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development, Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development, Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts, Phosphorylates PLCG1, FRS2 and PAK4, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation, Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling, Over-expressed FGFR2 promotes activation of STAT1 (By similarity)


This is Fibroblast growth factor receptor 1 protein, from Iberian ribbed newt, contains 816 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Fibroblast growth factor receptor 2 protein, from Iberian ribbed newt, contains 824 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Fibroblast growth factor receptor 3 protein, from Iberian ribbed newt, contains 796 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis, Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development, Regulates both osteogenesis and postnatal bone mineralization by osteoblasts, Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation, Phosphorylates PLCG1, CBL and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)


This is Retinoic acid receptor gamma-A protein, from Zebrafish, contains 499 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), Required for hindbrain development and for the development of pharyngeal arches


This is Transcription factor GATA-3 protein, from Zebrafish, contains 438 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type


This is Zinc finger protein ZIC 2-A protein, from African clawed frog, contains 503 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation, Regulates anteroposterior patterning in early development by inhibiting expression of the nodal genes through the inhibition of vegt, Required for gastrulation movements and for proper anterior neural and axial development, May also act as a transcriptional activator, May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'

Belongs to the GLI C2H2-type zinc-finger protein family


This is DNA replication licensing factor mcm7-A protein, from African clawed frog, contains 720 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development


This is Mast/stem cell growth factor receptor-related protein Kit protein, from African clawed frog, contains 954 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is BDNF/NT-3 growth factors receptor protein, from Chicken, contains 818 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4 (PubMed:8287802, PubMed:8670834), Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:8670834), Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions, May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia (By similarity)


This is E3 ubiquitin-protein ligase ZNRF1 protein, from Mouse, contains 227 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation, Plays a role in the establishment and maintenance of neuronal transmission and plasticity, Regulates Schwann cells differentiation by mediating ubiquitination of GLUL, Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons


This is Melanophilin protein, from Mouse, contains 590 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab effector protein involved in melanosome transport, Serves as link between melanosome-bound RAB27A and the motor protein MYO5A


This is N-chimaerin protein, from Mouse, contains 459 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

GTPase-activating protein for p21-rac and a phorbol ester receptor, May play an important role in neuronal signal-transduction mechanisms (By similarity), Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance


This is Fibroblast growth factor receptor-like 1 protein, from Mouse, contains 529 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Has a negative effect on cell proliferation


This is Zinc finger and BTB domain-containing protein 1 protein, from Mouse, contains 713 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 UBZ-type Zinc finger, has 5 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

UBZ-type

Acts as a transcriptional repressor (By similarity), Represses cAMP-responsive element (CRE)-mediated transcriptional activation (By similarity), In addition, has a role in translesion DNA synthesis, Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (By similarity), Plays a key role in the transcriptional regulation of T lymphocyte development (PubMed:22201126, PubMed:22753936)