This is Nuclear hormone receptor family member nhr-65 protein, from Caenorhabditis elegans, contains 401 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Norway spruce, contains 319 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is RING-H2 finger protein ATL29 protein, from Mouse-ear cress, contains 289 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Belongs to the RING-type zinc finger family, ATL subfamily


This is GATA transcription factor 2 protein, from Mouse-ear cress, contains 264 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters, May be involved in the regulation of some light-responsive genes

Belongs to the type IV zinc-finger family, Class A subfamily


This is GATA transcription factor 4 protein, from Mouse-ear cress, contains 240 amino acids, has 1 GATA-type Zinc finger.

GATA-type


This is DNA primase protein, from Borrelia burgdorferi, contains 523 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is UvrABC system protein A protein, from Borrelia burgdorferi, contains 950 amino acids, has 2 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate

Belongs to the ABC transporter superfamily, UvrA family


This is Chaperone protein DnaJ protein, from Pasteurella haemolytica, contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Chaperone protein DnaJ 2 protein, from Streptomyces albus G, contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type


This is DNA primase protein, from Mycobacterium smegmatis, contains 636 amino acids, has 1 CHC2-type Zinc finger.


This is Interleukin-1-binding protein protein, from VACV, contains 326 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

May reduce the host inflammatory response by interacting with inteleukin-1 beta (Il1b) and thus decreasing the association between IL1B and its cellular receptor

Belongs to the interleukin-1 receptor family


This is Thyroid hormone receptor alpha protein, from Mudpuppy, contains 408 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Large ribosomal subunit protein eL42 protein, from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3), contains 94 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL42 family


This is Cytoplasmic 60S subunit biogenesis factor SPCC550.15c protein, from Fission yeast, contains 463 amino acids, has 4 C2H2-type Zinc finger.

Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit, Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity)


This is Nuclear hormone receptor family member nhr-61 protein, from Caenorhabditis elegans, contains 412 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Belongs to the nuclear hormone receptor family


This is Protein hunchback protein, from Fruit fly, contains 757 amino acids, has 6 C2H2-type Zinc finger.

Gap class segmentation protein that controls development of head structures

Belongs to the hunchback C2H2-type zinc-finger protein family


This is Protein hunchback protein, from Fruit fly, contains 759 amino acids, has 6 C2H2-type Zinc finger.


This is Putative inhibitor of apoptosis protein, from Pig, contains 358 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Zinc finger X-chromosomal protein protein, from Bovine, contains 800 amino acids, has 13 C2H2-type Zinc finger.

Belongs to the krueppel C2H2-type zinc-finger protein family, ZFX/ZFY subfamily


This is Small ribosomal subunit protein eS27z protein, from Mouse-ear cress, contains 84 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eS27 family


This is RING-H2 finger protein ATL38 protein, from Mouse-ear cress, contains 302 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is GATA transcription factor 7 protein, from Mouse-ear cress, contains 238 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters, May be involved in the regulation of some light-responsive genes (By similarity)


This is DNA repair protein RadA protein, from Aquifex aeolicus (strain VF5), contains 444 amino acids, has 1 C4-type Zinc finger.

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks, Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster, Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB, Does not have RecA's homology-searching function

Belongs to the RecA family, RadA subfamily


This is UvrABC system protein A protein, from Aquifex aeolicus (strain VF5), contains 926 amino acids, has 2 C4-type Zinc finger.


This is Chaperone protein DnaJ 2 protein, from Aquifex aeolicus (strain VF5), contains 376 amino acids, has 1 CR-type Zinc finger.

CR-type


This is DNA primase protein, from Aquifex aeolicus (strain VF5), contains 498 amino acids, has 1 CHC2-type Zinc finger.


This is Chaperone protein DnaJ 1 protein, from Aquifex aeolicus (strain VF5), contains 364 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Bacillus sphaericus, contains 368 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Mycobacterium leprae (strain TN), contains 282 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is Protein OPG185 protein, from CPV, contains 314 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane, The OPG185-OPG040 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation, Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack

Belongs to the orthopoxvirus OPG185 family


This is Transcription factor COE3 protein, from African clawed frog, contains 598 amino acids, has 1 C5-type Zinc finger.


This is Large ribosomal subunit protein eL43 protein, from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3), contains 83 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL43 family, Putative zinc-binding subfamily


This is Nucleoporin-like protein amo1 protein, from Fission yeast, contains 475 amino acids, has 1 C3H1-type Zinc finger.

Involved in the cell polarity process where it is required for the correct termination of microtubule growth at the cell ends during interphase


This is Small ribosomal subunit protein eS27 protein, from Fission yeast, contains 83 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel


This is General transcription and DNA repair factor IIH subunit tfb4 protein, from Fission yeast, contains 297 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription


This is Uncharacterized protein C1739.01 protein, from Fission yeast, contains 547 amino acids, has 2 C3H1-type Zinc finger.


This is Mst2 complex subunit nto1 protein, from Fission yeast, contains 767 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation


This is Zinc finger CCCH domain-containing protein C337.12 protein, from Fission yeast, contains 376 amino acids, has 4 C3H1-type Zinc finger.


This is Putative box C/D snoRNA protein SPCC613.07 protein, from Fission yeast, contains 345 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis


This is Zinc finger protein 623 protein, from Human, contains 536 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein 780A protein, from Human, contains 641 amino acids, has 17 C2H2-type Zinc finger.


This is Zinc finger protein 737 protein, from Human, contains 536 amino acids, has 13 C2H2-type Zinc finger.


This is Zinc finger protein 324A protein, from Human, contains 553 amino acids, has 9 C2H2-type Zinc finger.

May be involved in transcriptional regulation, May be involved in regulation of cell proliferation


This is Zinc finger protein 189 protein, from Human, contains 626 amino acids, has 16 C2H2-type Zinc finger.


This is Protein ultraspiracle homolog protein, from Spruce budworm moth, contains 472 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone, May be an important modulator of insect metamorphosis (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Nuclear hormone receptor family member nhr-42 protein, from Caenorhabditis elegans, contains 356 amino acids, has 1 NR C4-type Zinc finger, has 1 NR C4-type; atypical Zinc finger.

NR C4-type

NR C4-type; atypical


This is Nuclear hormone receptor E75 protein, from Greasyback shrimp, contains 606 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Beta-2-microglobulin protein, from Black-fronted titi, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system (By similarity)

Belongs to the beta-2-microglobulin family


This is Deformed epidermal autoregulatory factor 1 homolog protein, from Chimpanzee, contains 565 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene, Down-regulates transcription of these genes, Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3', Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction, Regulates epithelial cell proliferation and side-branching in the mammary gland, Required for neural tube closure and skeletal patterning, Controls the expression of peripheral tissue antigens in pancreatic lymph nodes, Transcriptional activator of EIF4G3, May also involved in behavior (By similarity)


This is RING-H2 finger protein ATL33 protein, from Mouse-ear cress, contains 235 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Zinc finger protein 10 protein, from Mouse-ear cress, contains 304 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor that may regulate cell division and growth


This is Dof zinc finger protein DOF1.7 protein, from Mouse-ear cress, contains 194 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence


This is Zinc finger CCCH domain-containing protein 23 protein, from Mouse-ear cress, contains 315 amino acids, has 2 C3H1-type Zinc finger.


This is RING-H2 finger protein ATL67 protein, from Mouse-ear cress, contains 214 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is GATA transcription factor 9 protein, from Mouse-ear cress, contains 308 amino acids, has 1 GATA-type Zinc finger.

GATA-type


This is Primosomal protein N' protein, from Treponema pallidum (strain Nichols), contains 657 amino acids, has 2 C4-type Zinc finger.

Involved in the restart of stalled replication forks, Recognizes and binds the arrested nascent DNA chain at stalled replication forks, It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA

Belongs to the helicase family, PriA subfamily


This is DNA primase protein, from Treponema pallidum (strain Nichols), contains 605 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is UvrABC system protein A protein, from Treponema pallidum (strain Nichols), contains 960 amino acids, has 2 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate


This is DNA repair protein RadA protein, from Treponema pallidum (strain Nichols), contains 455 amino acids, has 1 C4-type Zinc finger.

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks, Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster, Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB, Does not have RecA's homology-searching function


This is DNA repair protein RadA protein, from Chlamydia trachomatis (strain D/UW-3/Cx), contains 454 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Chlamydia trachomatis (strain D/UW-3/Cx), contains 392 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Primosomal protein N' protein, from Chlamydia trachomatis (strain D/UW-3/Cx), contains 753 amino acids, has 2 C4-type Zinc finger.


This is DNA primase protein, from Chlamydia trachomatis (strain D/UW-3/Cx), contains 595 amino acids, has 1 CHC2-type Zinc finger.


This is Chaperone protein DnaJ protein, from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168), contains 373 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Probable endonuclease 8 2 protein, from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145), contains 276 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Chaperone protein DnaJ protein, from Beneckea harveyi, contains 385 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Lactobacillus sakei, contains 383 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Zinc finger protein 37 protein, from Rat, contains 601 amino acids, has 11 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical


This is Zinc finger and BTB domain-containing protein 7A protein, from Chicken, contains 546 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation, Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity), May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ and in alternative splicing (By similarity)


This is Cyclic AMP-dependent transcription factor ATF-2 protein, from Chicken, contains 487 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response, Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3') (By similarity)

Belongs to the bZIP family, ATF subfamily


This is SET domain and MYND-type zinc finger protein 6 protein, from Fission yeast, contains 483 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is UPF0743 protein C215.06c protein, from Fission yeast, contains 180 amino acids, has 2 C2HC LYAR-type Zinc finger.

C2HC LYAR-type

C2HC LYAR-type


This is mRNA export factor rsm1 protein, from Fission yeast, contains 296 amino acids, has 1 C3HC-type Zinc finger.

Involved in the export of mRNA from the nucleus to the cytoplasm


This is DnaJ-related protein spj1 protein, from Fission yeast, contains 381 amino acids, has 1 CR-type Zinc finger.

CR-type


This is DnaJ protein homolog xdj1 protein, from Fission yeast, contains 413 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Large ribosomal subunit protein eL43B protein, from Fission yeast, contains 94 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL43 family


This is Zinc finger protein 432 protein, from Human, contains 652 amino acids, has 16 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Arf-GAP domain and FG repeat-containing protein 2 protein, from Human, contains 481 amino acids, has 1 C4-type Zinc finger.


This is T cell receptor alpha variable 8-4 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is Immunoglobulin kappa constant protein, from Mouse, contains 107 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T-cell receptor alpha chain constant protein, from Mouse, contains 136 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Constant region of T cell receptor (TR) alpha chain, Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens, Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation, The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity


This is Immunoglobulin heavy constant epsilon protein, from Rat, contains 429 amino acids, has 4 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Constant region of immunoglobulin heavy chains, Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens, The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen


This is Ig gamma-2A chain C region, A allele protein, from Mouse, contains 330 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like


This is Ig delta chain C region membrane-bound form protein, from Mouse, contains 290 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like


This is Beta-2-microglobulin protein, from Rabbit, contains 99 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system


This is H-2 class I histocompatibility antigen, alpha chain protein, from Mouse, contains 185 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is H-2 class II histocompatibility antigen, E-D beta chain protein, from Mouse, contains 264 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Small t antigen protein, from HaPyV, contains 194 amino acids, has 1 C4-type; atypical Zinc finger, has 1 H1C3-type; atypical Zinc finger.

C4-type; atypical

H1C3-type; atypical

Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle, Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit, Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters, Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation, May establish and maintain high levels of viral genomes during persistent infection in cell culture


This is Small t antigen protein, from BKPyV, contains 172 amino acids, has 1 C4-type; atypical Zinc finger, has 1 H1C3-type; atypical Zinc finger.

C4-type; atypical

H1C3-type; atypical


This is Small t antigen protein, from JCPyV, contains 172 amino acids, has 1 C4-type; atypical Zinc finger, has 1 H1C3-type; atypical Zinc finger.

C4-type; atypical

H1C3-type; atypical

Promotes efficient viral genome replication by modulating several host signaling pathways including transport network, interferon production or cell cycle progression (PubMed:20485545, PubMed:33092197, PubMed:33849980), Inhibits host PP2A phosphatase activity and thereby prevents agnoprotein dephosphorylation (PubMed:20485545, PubMed:18353419), Inactivation of PP2A also results in the transactivation of cyclin A and cyclin D1 promoters (By similarity), In addition, antagonizes the RIGI-mediated IFN response through interaction with E3 ligase TRIM25 leading to the inhibition of 'Lys-63'-linked ubiquitination of RIGI, Inhibits nucleotide excision repair (NER) pathway which leads to DNA strand breaks during DNA replication and micronuclei formation (PubMed:25744060)


This is Protein E6 protein, from CRPV, contains 273 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response

Belongs to the papillomaviridae E6 protein family


This is Protein E6 protein, from DPV, contains 135 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from CRPV, contains 94 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)

Belongs to the papillomaviridae E7 protein family


This is Protein E7 protein, from DPV, contains 102 amino acids, has 1  Zinc finger.


This is Envelope glycoprotein C protein, from HHV-2, contains 479 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate, Also plays a role in host immune evasion by inhibiting the host complement cascade activation (By similarity)

Belongs to the herpesviridae glycoprotein C family


This is Early E1A protein protein, from HAdV-7, contains 261 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E1A protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome, Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore, This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K, Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection, Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation, The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta), Promotes the sumoylation of host ZBED1/hDREF with SUMO1 (By similarity)

Belongs to the adenoviridae E1A protein family


This is Gag polyprotein protein, from MVV, contains 442 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Encapsulates and protects viral dimeric unspliced genomic RNA (gRNA), Binds these RNAs through its zinc fingers, Acts as a nucleic acid chaperone which is involved in rearrangement of nucleic acid secondary structure during gRNA retrotranscription, Also facilitates template switch leading to recombination

Belongs to the Ovine/caprine lentivirus group gag polyprotein family


This is Capsid protein protein, from CaMV, contains 489 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Self assembles to form an icosahedral capsid, about 50 nm in diameter, nm, composed of 420 subunits of the viral capsid protein, The capsid encapsulates the genomic dsDNA, Following virus entry into host cell, provides nuclear import of the viral genome, Virus particles do not enter the nucleus, but dock at the nuclear membrane through the interaction with host importins (By similarity)

Belongs to the caulimoviridae capsid protein family


This is Capsid protein protein, from CaMV, contains 488 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Capsid protein protein, from CaMV, contains 490 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Capsid protein protein, from ACMV, contains 258 amino acids, has 1  Zinc finger.

Encapsidates the viral DNA into characteristic twinned ('geminate') particles, Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus, The CP of bipartite geminiviruses is not required for cell-to-cell or systemic movement

Belongs to the geminiviridae capsid protein family


This is A protein protein, from Bacteriophage G4, contains 554 amino acids, has 1  Zinc finger.

The A* protein binds to double-stranded DNA and prevents their hydrolysis by nucleases


This is T cell receptor gamma constant 2 protein, from Human, contains 189 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447), Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1, Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415), Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT, This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089), Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes, The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames, The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714)


This is Protein E6 protein, from Human papillomavirus 11, contains 150 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation, In turn, apoptosis induced by DNA damage is inhibited, E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response


This is Intracisternal A-particle Gag-related polyprotein protein, from IAP-H18, contains 572 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell


This is H-2 class II histocompatibility antigen, E-K alpha chain protein, from Mouse, contains 255 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is DNA primase protein, from Bacillus subtilis (strain 168), contains 603 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is Probable capsid protein protein, from CERV, contains 494 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Primosomal protein N' protein, from Rhodospirillum rubrum, contains 811 amino acids, has 2 C4-type Zinc finger.

Involved in the restart of stalled replication forks, Recognizes and binds the arrested nascent DNA chain at stalled replication forks, It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA


This is Rano class II histocompatibility antigen, A beta chain protein, from Rat, contains 233 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-U beta chain protein, from Mouse, contains 263 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Protein E6 protein, from Human papillomavirus type 8, contains 155 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 33, contains 97 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 8, contains 103 amino acids, has 1  Zinc finger.


This is 45 kDa immediate-early protein 2 protein, from HHV-5, contains 410 amino acids, has 1  Zinc finger.

Activates the E1,7 promoter, This activation is augmented by the IE1 protein, It down-regulates the transcription of genes under the control of the major IE promoter


This is Protein E6 protein, from Human papillomavirus type 6b, contains 150 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 6b, contains 98 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Human papillomavirus type 1a, contains 93 amino acids, has 1  Zinc finger.


This is Envelope glycoprotein C protein, from HHV-2, contains 480 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Early E1A protein protein, from SAdV-7, contains 266 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E1A protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome, Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore, This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K, Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection, Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation, The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif


This is Protein E6 protein, from Human papillomavirus type 1a, contains 140 amino acids, has 2  Zinc finger.


This is Protein E6 protein, from Human papillomavirus 5, contains 157 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from Human papillomavirus 5, contains 103 amino acids, has 1  Zinc finger.


This is Protein E7 protein, from Bovine papillomavirus type 1, contains 127 amino acids, has 1  Zinc finger.


This is DNA primase protein, from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), contains 581 amino acids, has 1 CHC2-type Zinc finger.


This is A' protein protein, from Bacteriophage S13, contains 522 amino acids, has 1  Zinc finger.


This is Outer capsid protein sigma-3 protein, from T1L, contains 365 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3

Belongs to the orthoreovirus sigma-3 protein family


This is Zinc finger protein ZFP2 protein, from Mouse, contains 459 amino acids, has 13 C2H2-type Zinc finger.

Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance


This is Protein E7 protein, from Bovine papillomavirus 4, contains 98 amino acids, has 1  Zinc finger.


This is Protein OPG185 protein, from VACV, contains 315 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane, The OPG185-OPG040 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation, Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack

Belongs to the orthopoxvirus OPG185 family


This is Pre-rRNA-processing protein SRD1 protein, from Baker's yeast, contains 221 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Plays a direct or indirect role in pre-rRNA processing


This is E3 ubiquitin-protein ligase IE61 protein, from HHV-3, contains 467 amino acids, has 1 RING-type Zinc finger.

RING-type

RING-finger E3 ubiquitin ligase that degrades host SP100, one of the major components of ND10 nuclear bodies, thereby disrupting the organization of these bodies, Also plays a role in the inhibition of host NF-kappa-B pathway by blocking the SCF(BTRC)-mediated addition of ubiquitin chains to host I-kappa-B-alpha/NFKBIA, thereby interfering with its degradation


This is Probable capsid protein protein, from FMV, contains 489 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Unique short US10 glycoprotein protein, from HHV-5, contains 185 amino acids, has 1 Ig-like H-type Immunoglobulin domain.

Ig-like H-type

Plays a role in the modulation of host immune response by reducing the presentation of HLA-G molecules at the cell surface, Selectively targets HLA-G molecules for degradation by a mechanism distinct from that used by US11


This is Unique short US8 glycoprotein protein, from HHV-5, contains 227 amino acids, has 1 Ig-like H-type Immunoglobulin domain.

Ig-like H-type

Belongs to the cytomegalovirus US6 family


This is Unique short US7 glycoprotein protein, from HHV-5, contains 225 amino acids, has 1 Ig-like H-type Immunoglobulin domain.

Ig-like H-type


This is DNA primase protein, from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440), contains 660 amino acids, has 1 CHC2-type Zinc finger.


This is DNA primase protein, from Arthrobacter siderocapsulatus, contains 660 amino acids, has 1 CHC2-type Zinc finger.


This is UvrABC system protein A protein, from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), contains 941 amino acids, has 2 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate

Belongs to the ABC transporter superfamily, UvrA family


This is UvrABC system protein A protein, from Salmonella typhi, contains 941 amino acids, has 2 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Salmonella typhi, contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Recombination protein RecR protein, from Streptococcus pneumoniae (strain ATCC BAA-255 / R6), contains 198 amino acids, has 1 C4-type Zinc finger.

May play a role in DNA repair, It seems to be involved in an RecBC-independent recombinational process of DNA repair, It may act with RecF and RecO (By similarity), Plays no role in chromosomal or plasmid transformation but is required for resolution of chromosome dimers occurring as intermediates in the formation of merodiploids by transformation (PubMed:25569614)


This is Chaperone protein DnaJ 1 protein, from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97), contains 395 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Probable primosomal protein N' protein, from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97), contains 655 amino acids, has 2 C4-type Zinc finger.


This is UvrABC system protein A protein, from Shigella flexneri, contains 940 amino acids, has 2 C4-type Zinc finger.


This is Recombination protein RecR protein, from Escherichia coli (strain K12), contains 201 amino acids, has 1 C4-type Zinc finger.

May play a role in DNA repair, It seems to be involved in an RecBC-independent recombinational process of DNA repair, It may act with RecF and RecO


This is Transcriptional repressor NrdR protein, from Escherichia coli (strain K12), contains 149 amino acids, has 1  Zinc finger.

Represses transcription of the class Ib RNR genes nrdHIEF but has much smaller effect on transcription of the class Ia RNR genes nrdAB and class III RNR genes nrdDG, By binding to nrdR boxes in the promoter regions to alter promoter activity, nrdR differentially regulates nrdAB, nrdHIEF and nrdD transcription in aerobic growth


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Escherichia coli O157:H7, contains 304 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is DNA primase protein, from Escherichia coli O157:H7, contains 581 amino acids, has 1 CHC2-type Zinc finger.


This is DNA primase protein, from Shigella flexneri, contains 581 amino acids, has 1 CHC2-type Zinc finger.


This is Thioredoxin 2 protein, from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC), contains 139 amino acids, has 1  Zinc finger.

Efficient electron donor for the essential enzyme ribonucleotide reductase, Is also able to reduce the interchain disulfide bridges of insulin (By similarity)


This is Thioredoxin 2 protein, from Escherichia coli O157:H7, contains 139 amino acids, has 1  Zinc finger.


This is Thioredoxin 2 protein, from Shigella flexneri, contains 139 amino acids, has 1  Zinc finger.


This is RING-H2 finger protein ATL10 protein, from Mouse-ear cress, contains 251 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Belongs to the RING-type zinc finger family, ATL subfamily


This is RING-H2 finger protein ATL60 protein, from Mouse-ear cress, contains 310 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Putative RING-H2 finger protein ATL53 protein, from Mouse-ear cress, contains 310 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Chaperone protein DnaJ protein, from Streptococcus pyogenes, contains 378 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Streptococcus pyogenes serotype M1, contains 378 amino acids, has 1 CR-type Zinc finger.

CR-type


This is UvrABC system protein A protein, from Brucella abortus biovar 1 (strain 9-941), contains 974 amino acids, has 1 C4-type Zinc finger.


This is Leukocyte-associated immunoglobulin-like receptor 1 protein, from Rat, contains 263 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells, Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11, It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation, May also play its inhibitory role independently of SH2-containing phosphatases, Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta, Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion, Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells, Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity)


This is Small t antigen protein, from MPyV, contains 195 amino acids, has 1 C4-type; atypical Zinc finger, has 1 H1C3-type; atypical Zinc finger.

C4-type; atypical

H1C3-type; atypical

Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle, Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit, Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters, Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation, May establish and maintain high levels of viral genomes during persistent infection in cell culture


This is GATA-type zinc finger protein 1 protein, from Human, contains 271 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional regulator that plays a key role in germ cell development, Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry, Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells, Regulates expression of STRA8, a central downstream effector for the meiotic program, Acts independently of retinoic acid (RA), In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase


This is Secreted protein BARF1 protein, from HHV-4, contains 221 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1, May inhibit interferon secretion from mononuclear cells, Exhibits oncogenic activity in vitro (By similarity)


This is Transcription factor YY2 protein, from Rat, contains 376 amino acids, has 4 C2H2-type Zinc finger.

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes, May antagonize YY1 and function in development and differentiation (By similarity)

Belongs to the YY transcription factor family


This is Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 protein, from Human, contains 592 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type


This is host range factor p28 protein, from VACV, contains 239 amino acids, has 1 RING-type Zinc finger.

RING-type

RING-finger E3 ubiquitin ligase which catalyzes the formation of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, Plays an important role in virulence by acting as an anti-apoptotic factor

Belongs to the orthopoxvirus OPG021 family


This is Putative zinc finger protein 735 protein, from Human, contains 412 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 6 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 3; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), contains 288 amino acids, has 1 C4-type Zinc finger.


This is PAN2-PAN3 deadenylation complex subunit pan3 protein, from Social amoeba, contains 746 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP), PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP

Belongs to the protein kinase superfamily, PAN3 family


This is T cell receptor gamma constant 1 protein, from Human, contains 173 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447), Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1, Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415), Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT, This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089), Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes, The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames, The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714)


This is Putative zinc finger and SCAN domain-containing protein 5D protein, from Human, contains 497 amino acids, has 5 C2H2-type Zinc finger.


This is Transcription factor Sp9 protein, from Human, contains 484 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor which plays a key role in limb development, Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Putative RING-H2 finger protein ATL21A protein, from Mouse-ear cress, contains 372 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Putative RING-H2 finger protein ATL21B protein, from Mouse-ear cress, contains 362 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Putative RING-H2 finger protein ATL21C protein, from Mouse-ear cress, contains 366 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Zinc finger protein 705D protein, from Human, contains 300 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 4; degenerate


This is Tripartite motif-containing protein 49C protein, from Human, contains 452 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Capsid protein protein, from BGYMV, contains 250 amino acids, has 1  Zinc finger.

Encapsidates the viral DNA into characteristic twinned ('geminate') particles, Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus, The CP of bipartite geminiviruses is not required for cell-to-cell or systemic movement


This is Capsid protein protein, from BGYMV, contains 251 amino acids, has 1  Zinc finger.


This is Transcriptional activator protein protein, from BGYMV, contains 172 amino acids, has 1  Zinc finger.

Strong activator of the late viral genes promoters, Enhances the expression of the capsid protein and nuclear shuttle protein, Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs, Suppresses the host RNA silencing by inhibiting adenosine kinase 2 (ADK2), a kinase involved in a general methylation pathway, Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense, Determines pathogenicity (By similarity)

Belongs to the geminiviridae transcriptional activator protein family


This is Nuclear egress protein 1 protein, from HHV-4, contains 318 amino acids, has 1 CCCH-type Zinc finger.

CCCH-type

Plays an essential role in virion nuclear egress, the first step of virion release from infected cell, Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2, Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space, There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network

Belongs to the herpesviridae NEC1 protein family


This is Endonuclease 8 protein, from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), contains 263 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Structure-specific endonuclease subunit SLX1 protein, from Filobasidiella neoformans, contains 487 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA


This is JmjC domain-containing histone demethylation protein 1 protein, from Filobasidiella neoformans, contains 879 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code

Belongs to the JHDM1 histone demethylase family


PHD-type


This is Branchpoint-bridging protein protein, from Filobasidiella neoformans, contains 546 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Necessary for the splicing of pre-mRNA, Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity)


CCHC-type

CCHC-type


This is PAN2-PAN3 deadenylation complex subunit PAN3 protein, from Filobasidiella neoformans, contains 684 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1


This is E3 ubiquitin-protein ligase BRE1 protein, from Filobasidiella neoformans, contains 820 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation


RING-type


This is Pre-mRNA-splicing factor CWC2 protein, from Filobasidiella neoformans, contains 342 amino acids, has 1 C3H1-type Zinc finger.

Involved in the first step of pre-mRNA splicing, Required for cell growth and cell cycle control, Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex, May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA, Associates predominantly with U6 snRNAs in assembled active spliceosomes, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity)


This is Transcription elongation factor SPT4 protein, from Filobasidiella neoformans, contains 113 amino acids, has 1 C4-type Zinc finger.

The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing, This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity)


This is Vacuolar protein sorting-associated protein 27 protein, from Filobasidiella neoformans, contains 750 amino acids, has 1 FYVE-type; degenerate Zinc finger.

FYVE-type; degenerate

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane


This is pH-response transcription factor pacC/RIM101 protein, from Filobasidiella neoformans, contains 917 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH, At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid-expressed genes (By similarity)


This is Chaperone protein DnaJ protein, from Methanosarcina frisia, contains 389 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


CR-type


This is Secreted protein BARF1 protein, from HHV-4, contains 221 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1, May inhibit interferon secretion from mononuclear cells, Exhibits oncogenic activity in vitro (By similarity)


This is UvrABC system protein A protein, from Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315), contains 942 amino acids, has 2 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate


This is UvrABC system protein A protein, from Streptococcus pyogenes serotype M3 (strain SSI-1), contains 942 amino acids, has 2 C4-type Zinc finger.


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315), contains 288 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Streptococcus pyogenes serotype M3 (strain SSI-1), contains 288 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315), contains 378 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Streptococcus pyogenes serotype M3 (strain SSI-1), contains 378 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315), contains 275 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Formamidopyrimidine-DNA glycosylase protein, from Streptococcus pyogenes serotype M3 (strain SSI-1), contains 275 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is DNA repair protein RadA protein, from Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315), contains 453 amino acids, has 1 C4-type Zinc finger.

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks, Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster, Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB, Does not have RecA's homology-searching function

Belongs to the RecA family, RadA subfamily


This is DNA repair protein RadA protein, from Streptococcus pyogenes serotype M3 (strain SSI-1), contains 453 amino acids, has 1 C4-type Zinc finger.


This is Squamosa promoter-binding-like protein 13B protein, from Mouse-ear cress, contains 359 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'


This is Large ribosomal subunit protein eL37 protein, from Tetrahymena thermophila (strain SB210), contains 94 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL37 family


This is Chaperone protein DnaJ protein, from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e), contains 377 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2 protein, from Mouse-ear cress, contains 755 amino acids, has 1 C2H2-type Zinc finger.

Polycomb group (PcG) protein, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility, Required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization, Regulates the anteroposterior organization of the endosperm

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is Glyco-Gag protein protein, from FrMLV, contains 627 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Plays a role in viral particle release, Presumably acts by facilitating the fission of the virion bud at the cell surface, May prevent the antiviral activity of murine APOBEC3


This is Glyco-Gag protein protein, from FrMLV, contains 626 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


CCHC-type


This is Immunoglobulin alpha-2 heavy chain protein, from Human, contains 455 amino acids, has 4 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170), Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915)


This is Immunoglobulin kappa light chain protein, from Human, contains 214 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin lambda-1 light chain protein, from Human, contains 216 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like


This is Immunoglobulin heavy variable 1-8 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin heavy variable 3-30-3 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-30-5 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-43D protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 4-30-4 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 4-31 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 4-38-2 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 1-13 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is V-set and immunoglobulin domain-containing protein 10-like 2 protein, from Human, contains 767 amino acids, has 5 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like


This is T cell receptor alpha variable 35 protein, from Human, contains 110 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is T cell receptor beta variable 6-3 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is Probable non-functional immunoglobulinn kappa variable 1D-37 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447), Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Probable non-functional immunoglobulin heavy variable 3-38-3 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447), Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170, PubMed:22158414, PubMed:24600447)


This is Probable non-functional immunoglobulin heavy variable 8-51-1 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Zinc finger TRAF-type-containing protein 1 protein, from Human, contains 404 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type


This is Probable non-functional immunoglobulin heavy variable 1-38-4 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447), Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin heavy constant alpha protein, from Donkey, contains 346 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Constant region of immunoglobulin heavy chains, Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens, The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen, Ig alpha is the major immunoglobulin class in body secretions


This is Zinc finger protein GLI4 protein, from Human, contains 376 amino acids, has 7 C2H2-type Zinc finger.


This is Zinc finger protein 26 protein, from Mouse, contains 861 amino acids, has 22 C2H2-type Zinc finger, has 1 C2H2-type 23; degenerate Zinc finger.

C2H2-type 23; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 27 protein, from Mouse, contains 819 amino acids, has 21 C2H2-type Zinc finger.


This is Early E1A protein protein, from HAdV-4, contains 257 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E1A protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome, Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore, This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K, Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection, Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation, The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta), Promotes the sumoylation of host ZBED1/hDREF with SUMO1 (By similarity)

Belongs to the adenoviridae E1A protein family


This is Early E1A protein protein, from HAdV-40, contains 249 amino acids, has 1  Zinc finger.


This is Early E1A protein protein, from HAdV-41, contains 251 amino acids, has 1  Zinc finger.


This is Envelope glycoprotein C homolog protein, from GaHV-2, contains 505 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

May play an immunoevasive role in the pathogenesis of Marek's disease, It is a candidate for causing the early-stage immunosuppression that occurs after MDHV infection

Belongs to the herpesviridae glycoprotein C family


This is Zinc finger protein 14 protein, from Mouse, contains 501 amino acids, has 13 C2H2-type Zinc finger.


This is Hyaluronan and proteoglycan link protein 1 protein, from Pig, contains 354 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix

Secreted, extracellular space, extracellular matrix


This is Zinc finger Y-chromosomal protein 1 protein, from Mouse, contains 782 amino acids, has 13 C2H2-type Zinc finger.

Probable transcriptional activator, Binds to the consensus sequence 5'-AGGCCY-3' (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family, ZFX/ZFY subfamily


This is Protein E6 protein, from Bovine papillomavirus 2, contains 137 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity, Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1, May also inhibit host immune response

Belongs to the papillomaviridae E6 protein family


This is Protein E7 protein, from Bovine papillomavirus 2, contains 127 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)

Belongs to the papillomaviridae E7 protein family


This is Protein E6 protein, from EEPV, contains 135 amino acids, has 2  Zinc finger.


This is Protein E7 protein, from EEPV, contains 102 amino acids, has 1  Zinc finger.


This is Intracisternal A-particle Gag-related polyprotein protein, from IAP-MIA14, contains 827 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell


This is Pregnancy-specific beta-1-glycoprotein 2 protein, from Human, contains 335 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, CEA family


This is Opioid-binding protein/cell adhesion molecule protein, from Bovine, contains 345 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Binds opioids in the presence of acidic lipids; probably involved in cell contact

Belongs to the immunoglobulin superfamily, IgLON family


This is Tripartite terminase subunit 1 protein, from SuHV-1, contains 724 amino acids, has 1 C3H1-type Zinc finger.

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging, Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm, Once the complex reaches the host nucleus, it interacts with the capsid portal vertex, This portal forms a ring in which genomic DNA is translocated into the capsid, TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes

Belongs to the herpesviridae TRM1 protein family


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Liverwort, contains 316 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Tripartite terminase subunit 1 protein, from HHV-1, contains 785 amino acids, has 1 C3H1-type Zinc finger.


This is Protein D7 protein, from African clawed frog, contains 278 amino acids, has 2 CHHC U11-48K-type Zinc finger.

CHHC U11-48K-type

CHHC U11-48K-type

Involved in oocyte maturation, It is possible that D7 is required at a certain point in the maturation process and that maturation cannot proceed beyond this point unless a threshold amount of D7 protein is provided


This is Knirps-related protein protein, from Fruit fly, contains 647 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Belongs to the nuclear hormone receptor family, NR0 subfamily


This is UvrABC system protein A protein, from Micrococcus lysodeikticus, contains 992 amino acids, has 1 C4-type; atypical Zinc finger, has 1 C4-type Zinc finger.

C4-type; atypical

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate

Belongs to the ABC transporter superfamily, UvrA family


This is Capsid protein protein, from ACMV, contains 258 amino acids, has 1  Zinc finger.

Encapsidates the viral DNA into characteristic twinned ('geminate') particles, Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus, The CP of bipartite geminiviruses is not required for cell-to-cell or systemic movement

Belongs to the geminiviridae capsid protein family