This is Transcriptional regulator STP3 protein, from Yeast, contains 436 amino acids, has 1 C2H2-type Zinc finger.

Transcription factor that activates genes required for degradation of extracellular protein and uptake of peptides such as the secreted aspartyl protease SAP2 or the oligopeptide transporter OPT1, Required for virulence, Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Aspergillus nidulans, contains 714 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)

Belongs to the Dus family, Dus3 subfamily


This is PAN2-PAN3 deadenylation complex subunit pan3 protein, from Aspergillus nidulans, contains 661 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1

Belongs to the protein kinase superfamily, PAN3 family


This is Protrudin protein, from Bovine, contains 404 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport, Promotes axonal elongation and contributes to the establishment of neuronal cell polarity, Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner, Contributes to both the formation and stabilization of the tubular ER network, Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections, Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons, Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner


This is E3 ubiquitin-protein ligase TRIM69 protein, from Rat, contains 499 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus, Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection, In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity, Plays also a role in cataract formation together with TP53, Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination


This is E3 ubiquitin-protein ligase XIAP protein, from Western clawed frog, contains 492 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins, Acts as a direct caspase inhibitor, E3 ubiquitin-protein ligase that acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of ripk2 downstream of NOD1 and NOD2, thereby transforming ripk2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity), A key apoptotic suppressor in eggs, Acts as a positive regulator of Wnt signaling (By similarity)


This is Fc receptor-like B protein, from Mouse, contains 427 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is Zinc finger protein Gfi-1 protein, from Dog, contains 422 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor essential for hematopoiesis, Functions in a cell-context and development-specific manner, Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes, Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development, Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development, Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment, Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling, Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA, Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth, Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters, Required for the maintenance of inner ear hair cells


This is E3 ubiquitin-protein ligase RNF25 protein, from Bovine, contains 458 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes, Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14, RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17, Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (By similarity), Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity), May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (By similarity)


This is DNA-(apurinic or apyrimidinic site) endonuclease 2 protein, from Bovine, contains 514 amino acids, has 1 GRF-type Zinc finger.

GRF-type

Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (By similarity), Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (By similarity), Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities, Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (By similarity), Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents, In the nucleus functions in the PCNA-dependent BER pathway (By similarity), Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (By similarity), Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity), Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity)

Belongs to the DNA repair enzymes AP/ExoA family


This is Protein Jade-1 protein, from Bovine, contains 509 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity, Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation, May also promote acetylation of nucleosomal histone H4 by KAT5, Promotes apoptosis, May act as a renal tumor suppressor, Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function


This is Nectin-4 protein, from Bovine, contains 510 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1


This is CXXC-type zinc finger protein 1 protein, from Bovine, contains 658 amino acids, has 1 PHD-type Zinc finger, has 1 CXXC-type Zinc finger.

PHD-type

CXXC-type

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG


This is Semaphorin-4A protein, from Bovine, contains 762 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity), Regulates glutamatergic and GABAergic synapse development (By similarity), Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity), Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity), Promotes phosphorylation of TIMD2 (By similarity), Inhibits angiogenesis (By similarity), Promotes axon growth cone collapse (By similarity), Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity)


This is Protein lin-28 homolog A protein, from Western clawed frog, contains 195 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism, Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity), 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis, Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization, Suppressor of microRNA (miRNA) biogenesis, including that of let-7, Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase, This results in the terminal uridylation of target pre-miRNAs, Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity), Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins, Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation, Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity)


This is E3 ubiquitin-protein transferase MAEA protein, from Chicken, contains 396 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, MAEA is required for normal cell proliferation, The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity), Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity), Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity), Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis, Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity), May contribute to nuclear architecture and cells division events (By similarity)


This is Ubiquitin thioesterase OTU1 protein, from Chicken, contains 302 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore, Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel, Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains, Also able to hydrolyze 'Lys-11'-linked ubiquitin chains, Cleaves both polyubiquitin and di-ubiquitin


This is Protein CBFA2T3 protein, from Chicken, contains 591 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Functions as a transcriptional repressor, Regulates the proliferation and the differentiation of erythroid progenitors, Plays a role in granulocyte differentiation, May also function as an A-kinase-anchoring protein (By similarity)


This is Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 protein, from Rat, contains 770 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6)


This is T-cell immunoglobulin and mucin domain-containing protein 2 protein, from Rat, contains 349 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Probable receptor for SEMA4A involved in the regulation of T-cell function, The interaction with SEMA4A enhances T-cell activation (By similarity)

Belongs to the immunoglobulin superfamily, TIM family


This is Myosin-binding protein H-like protein, from Mouse, contains 355 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Myosin-binding protein which plays a role in cardiac function (PubMed:28778945), Seems to regulate conduction in the atria and ventricular conduction systems (PubMed:28778945)

Belongs to the immunoglobulin superfamily, MyBP family


This is Zinc finger protein 789 protein, from Human, contains 425 amino acids, has 8 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Putative E3 ubiquitin-protein ligase UNKL protein, from Mouse, contains 727 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

May participate in a protein complex showing an E3 ligase activity regulated by Rac1, Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2, Intrinsic E3 ligase activity has not been proven


This is E3 ubiquitin-protein ligase CHFR protein, from African clawed frog, contains 625 amino acids, has 1 RING-type Zinc finger, has 1 PBZ-type Zinc finger.

RING-type

PBZ-type

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons, Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus, Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome, May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress


This is Zinc finger MYND domain-containing protein 10 protein, from African clawed frog, contains 439 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a role in axonemal structure organization and motility, Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity), May act by indirectly regulating transcription of dynein proteins (By similarity)


This is Formamidopyrimidine-DNA glycosylase protein, from Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is DNA topoisomerase 1 protein, from Staphylococcus aureus (strain COL), contains 689 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is DNA topoisomerase 1 protein, from Staphylococcus epidermidis (strain ATCC 35984 / RP62A), contains 689 amino acids, has 3 C4-type Zinc finger.


This is Probable ribonuclease ZC3H12B protein, from Human, contains 836 amino acids, has 1 C3H1-type Zinc finger.

May function as RNase and regulate the levels of target RNA species


This is WW domain-binding protein 4 protein, from Rat, contains 374 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the spliceosome, May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex


This is NT-3 growth factor receptor protein, from Bolivian squirrel monkey, contains 825 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in nervous system and probably heart development, Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is DNA replication licensing factor MCM4 protein, from Rice, contains 862 amino acids, has 1 C4-type Zinc finger.

Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells


This is Probable E3 ubiquitin-protein ligase RZFP34 protein, from Rice, contains 302 amino acids, has 1 CHY-type Zinc finger, has 1 CTCHY-type Zinc finger, has 1 RING-type; atypical Zinc finger.

CHY-type

CTCHY-type

RING-type; atypical

Possesses transactivation activity in yeast cells (Ref,1), Involved in the regulation of stomatal aperture, May modulate the expression of genes that control stomata opening during heat shock or drought stress (PubMed:25002225)


This is Krueppel-like factor 17 protein, from Human, contains 389 amino acids, has 3 C2H2-type Zinc finger.

Transcription repressor that binds to the promoter of target genes and prevents their expression, Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer, Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression, May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Signal-regulatory protein beta-2 protein, from Human, contains 342 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type


This is Mitochondrial ubiquitin ligase activator of nfkb 1-A protein, from Zebrafish, contains 341 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology, Promotes mitochondrial fragmentation and influences mitochondrial localization, Inhibits cell growth, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is E3 ubiquitin-protein ligase RNF135 protein, from Rat, contains 415 amino acids, has 1 RING-type Zinc finger.

RING-type

E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response, Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway, Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway, This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway, Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway


This is XIAP-associated factor 1 protein, from Mouse, contains 273 amino acids, has 1 TRAF-type Zinc finger.

TRAF-type

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family, Inhibits anti-caspase activity of BIRC4, Induces cleavage and inactivation of BIRC4 independent of caspase activation, Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells, May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway, After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria, Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm, The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4, Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL, May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity)


This is Intercellular adhesion molecule 1 protein, from Western lowland gorilla, contains 532 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity)

Belongs to the immunoglobulin superfamily, ICAM family


This is Zinc finger protein 639 protein, from Rat, contains 485 amino acids, has 8 C2H2-type Zinc finger.

Binds DNA and may function as a transcriptional repressor


This is E3 ubiquitin-protein ligase MARCHF2 protein, from African clawed frog, contains 246 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Bifunctional apoptosis regulator protein, from Rat, contains 450 amino acids, has 1 RING-type Zinc finger.

RING-type

Apoptosis regulator, Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity)


This is Tripartite motif-containing protein 55 protein, from Rat, contains 545 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

May regulate gene expression and protein turnover in muscle cells


This is Structure-specific endonuclease subunit SLX1 protein, from Rat, contains 271 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA, Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs), Resolves HJs by generating two pairs of ligatable, nicked duplex products


This is T-cell surface glycoprotein CD3 gamma chain protein, from Pig, contains 182 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways, In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface, Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G


This is DNA cross-link repair 1A protein protein, from Chicken, contains 972 amino acids, has 1 UBZ4-type Zinc finger.

May be required for DNA interstrand cross-link repair

Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family


This is Probable E3 ubiquitin-protein ligase ZFP1 protein, from Rice, contains 523 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Belongs to the RING-type zinc finger family


This is Ubiquitin carboxyl-terminal hydrolase 5 protein, from Sumatran orangutan, contains 858 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers, Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly, Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity)


This is E3 ubiquitin-protein ligase Arkadia protein, from Sumatran orangutan, contains 986 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase (By similarity), Required for mesoderm patterning during embryonic development (By similarity), Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP, Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity), In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity), Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL, Associates with UBE2D2 as an E2 enzyme, Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates, Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (By similarity), Mediates ubiquitination and degradation of sumoylated PML (By similarity), The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity)


This is E3 ubiquitin-protein transferase MAEA protein, from Sumatran orangutan, contains 396 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, MAEA is required for normal cell proliferation, The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity), Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity), Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity), Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis, Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity), May contribute to nuclear architecture and cells division events (By similarity)


This is PHD finger protein 6 protein, from Sumatran orangutan, contains 365 amino acids, has 2 C2HC pre-PHD-type Zinc finger, has 2 PHD-type Zinc finger.

C2HC pre-PHD-type

PHD-type

C2HC pre-PHD-type

PHD-type

Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription


This is E3 ubiquitin-protein ligase TRIM16 protein, from Sumatran orangutan, contains 564 amino acids, has 2 B box-type Zinc finger.

B box-type

B box-type

E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages, Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2, Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B, In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage


This is U4/U6.U5 tri-snRNP-associated protein 2 protein, from Sumatran orangutan, contains 565 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome, Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint, Does not have ubiquitin-specific peptidase activity


This is Calcium-binding and coiled-coil domain-containing protein 2 protein, from Sumatran orangutan, contains 446 amino acids, has 1 UBZ1-type Zinc finger.

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity), Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity), Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity), Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity), May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity)


This is Protrudin protein, from Sumatran orangutan, contains 411 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport, Promotes axonal elongation and contributes to the establishment of neuronal cell polarity, Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner, Contributes to both the formation and stabilization of the tubular ER network, Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections, Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons, Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner


This is Replication protein A 70 kDa DNA-binding subunit protein, from Sumatran orangutan, contains 616 amino acids, has 1 C4-type Zinc finger.

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress, It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism, Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage, In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation, Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response, It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage, Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair, Also plays a role in base excision repair (BER) probably through interaction with UNG, Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage, May also play a role in telomere maintenance

Belongs to the replication factor A protein 1 family


This is Endoplasmic reticulum junction formation protein lunapark protein, from Sumatran orangutan, contains 428 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology, Involved in the stabilization of nascent three-way ER tubular junctions within the ER network, May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network, May be involved in limb and central nervous system development


This is Immunoglobulin-like domain-containing receptor 1 protein, from Sumatran orangutan, contains 546 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs), Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs, Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine, In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1

Belongs to the immunoglobulin superfamily, LISCH7 family


This is Optineurin protein, from Sumatran orangutan, contains 527 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8, Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation, Negatively regulates the induction of IFNB in response to RNA virus infection, Plays a neuroprotective role in the eye and optic nerve, Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52


This is E3 ubiquitin-protein ligase MARCHF6 protein, from Sumatran orangutan, contains 910 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation, Promotes ubiquitination of DIO2, leading to its degradation, Promotes ubiquitination of SQLE, leading to its degradation, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, May cooperate with UBE2G1


This is E3 ubiquitin-protein ligase MARCHF7 protein, from Sumatran orangutan, contains 707 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity), May be involved in T-cell proliferation by regulating LIF secretion (By similarity), May play a role in lysosome homeostasis (By similarity)


This is Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 protein, from Sumatran orangutan, contains 612 amino acids, has 1 RTR1-type Zinc finger.

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes, Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity), Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity)


This is Endonuclease 8-like 2 protein, from Sumatran orangutan, contains 332 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles), Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is E3 ubiquitin-protein ligase RNF180 protein, from Sumatran orangutan, contains 592 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2


This is Estrogen-related receptor gamma protein, from Sumatran orangutan, contains 435 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that acts as transcription activator in the absence of bound ligand, Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements, Induces the expression of PERM1 in the skeletal muscle (By similarity)

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Pre-mRNA-splicing factor RBM22 protein, from Sumatran orangutan, contains 420 amino acids, has 1 C3H1-type Zinc finger.

Required for pre-mRNA splicing as component of the activated spliceosome, Involved in the first step of pre-mRNA splicing, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle, Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses


This is E3 ubiquitin-protein ligase RNF139 protein, from Sumatran orangutan, contains 664 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death, Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER), Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression, Involved in the sterol-accelerated degradation of HMGCR, This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane, In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR, The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction, Required for INSIG1 ubiquitination, May be required for EIF3 complex ubiquitination


This is Next to BRCA1 gene 1 protein protein, from Sumatran orangutan, contains 894 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets


This is Major histocompatibility complex class I-related gene protein protein, from Sumatran orangutan, contains 340 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites, Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT), MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal, Expression and MAIT cell recognition seem to be ligand-dependent (By similarity)


This is Semaphorin-3C protein, from Sumatran orangutan, contains 751 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to plexin family members and plays an important role in the regulation of developmental processes, Required for normal cardiovascular development during embryogenesis, Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity)


This is E3 ubiquitin-protein ligase RNF146 protein, from Sumatran orangutan, contains 358 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex, Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2, Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation, Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48', May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location, Neuroprotective protein (By similarity), Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity), Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity), Does not affect PARP1 activation, Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity), Promotes cell survival after gamma-irradiation, Facilitates DNA repair (By similarity)


This is Retinoic acid receptor RXR-gamma protein, from Sumatran orangutan, contains 463 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is E3 ubiquitin-protein ligase RNF128 protein, from Sumatran orangutan, contains 428 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation, Functions as an inhibitor of cytokine gene transcription, Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production, Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse, Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals


This is E3 ubiquitin-protein ligase CHFR protein, from Sumatran orangutan, contains 571 amino acids, has 1 RING-type Zinc finger, has 1 PBZ-type Zinc finger.

RING-type

PBZ-type

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons, Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus, Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome, Promotes the ubiquitination and subsequent degradation of AURKA and PLK1, Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation, May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress


This is E3 ubiquitin-protein ligase RNF185 protein, from Sumatran orangutan, contains 192 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1, Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation, Protects cells from ER stress-induced apoptosis, Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway, Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity, Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2


This is Natural cytotoxicity triggering receptor 3 ligand 1 protein, from Sumatran orangutan, contains 454 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Triggers NCR3-dependent natural killer cell activation


This is Probable E3 ubiquitin-protein ligase RNF144A-A protein, from Zebrafish, contains 293 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates

Belongs to the RBR family, RNF144 subfamily


This is TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 protein, from Zebrafish, contains 711 amino acids, has 1 RanBP2-type Zinc finger.

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF), Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains, The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (By similarity), Involved in heart development (PubMed:20493459)


This is E3 ubiquitin-protein ligase TRIM35 protein, from Rat, contains 501 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response, Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway, Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2, Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling, Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway, Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth


This is Origin of replication complex subunit 1 protein, from Rice, contains 814 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Essential protein (By similarity), Component of the origin recognition complex (ORC) that binds origins of replication, It has a role in both chromosomal replication and mating type transcriptional silencing, Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity), H3K4me3 effector that regulates positively the transcription of a subset of genes (By similarity), Required for cell proliferation (PubMed:10996242)


This is Fanconi-associated nuclease 1 homolog protein, from Rice, contains 964 amino acids, has 1 UBZ4-type Zinc finger.

Nuclease required for the repair of DNA interstrand cross-links (ICL), Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions


This is Follistatin-related protein 4 protein, from Mouse, contains 841 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like


This is DNL-type zinc finger protein protein, from Human, contains 178 amino acids, has 1 DNL-type Zinc finger.

DNL-type

May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation


This is Zinc finger and BTB domain-containing protein 37 protein, from Human, contains 503 amino acids, has 3 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Signal-regulatory protein beta-1 isoform 3 protein, from Human, contains 398 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Ig-like C1-type

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes


This is Retinoic acid receptor RXR-beta protein, from Dog, contains 533 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)


This is E3 ubiquitin-protein ligase TRIM15 protein, from Rhesus macaque, contains 465 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis, Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2, Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN, Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS, Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1, Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm, Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs)


This is Serine/threonine-protein phosphatase 1 regulatory subunit 10 protein, from Rhesus macaque, contains 940 amino acids, has 1 C3H1-type Zinc finger.

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex, The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase, Mediates interaction of WDR82 and PPP1CA, Inhibitor of PPP1CA and PPP1CC phosphatase activities, Has inhibitory activity on PPP1CA only when phosphorylated, Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity)


This is THAP domain-containing protein 1 protein, from Rat, contains 210 amino acids, has 1 THAP-type Zinc finger.

THAP-type

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression, Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1, May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity)


This is Immunoglobulin superfamily member 11 protein, from Rat, contains 428 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Functions as a cell adhesion molecule through homophilic interaction, Stimulates cell growth (By similarity)


This is Zinc finger protein PLAG1 protein, from Rat, contains 499 amino acids, has 7 C2H2-type Zinc finger.

Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed, Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction, Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas, Cooperates with CBFB-MYH11 (By similarity)


This is Replication initiator 1 protein, from Mouse, contains 545 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 13 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 1; atypical

C2H2-type 4; atypical

Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication, Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone, Facilitates DNA bending (By similarity)


This is Ubiquitin thioesterase zranb1-A protein, from African clawed frog, contains 701 amino acids, has 3 RanBP2-type Zinc finger.

Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity), Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity), Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity), Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity), Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity), Required in the stress fiber dynamics and cell migration (By similarity)


This is Immunoglobulin superfamily member 5 protein, from Rat, contains 369 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells, Mediates calcium-independent homophilic cell adhesion, In testis, it may function as a cell adhesion molecule rather than a tight-junction protein, It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity)

Belongs to the immunoglobulin superfamily


This is A-kinase anchor protein 8 protein, from Dog, contains 698 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II), Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis, Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring, May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression, Required for cell cycle G2/M transition and histone deacetylation during mitosis, In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L, Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation, May be involved in regulation of DNA replication by acting as scaffold for MCM2, Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation, In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation, May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells, May act as a carrier protein of GJA1 for its transport to the nucleus, May play a repressive role in the regulation of rDNA transcription, Preferentially binds GC-rich DNA in vitro, In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions, Involved in modulation of Toll-like receptor signaling, Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity)


This is Zinc finger protein 691 protein, from Human, contains 315 amino acids, has 7 C2H2-type Zinc finger.


This is B box and SPRY domain-containing protein protein, from Human, contains 402 amino acids, has 1 B box-type Zinc finger.

B box-type

May regulate epithelial calcium transport by inhibiting TRPV5 activity


This is Forkhead box protein P1 protein, from African clawed frog, contains 578 amino acids, has 1 C2H2-type Zinc finger.


This is Immunoglobulin domain-containing protein oig-4 protein, from Caenorhabditis elegans, contains 155 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Required for the localization of acetylcholine receptors at neuromuscular junctions and for subsequently controlling the response evoked by receptor stimulation


This is PHD finger protein ALFIN-LIKE 5 protein, from Mouse-ear cress, contains 260 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Methyl-CpG-binding domain-containing protein 1 protein, from Mouse-ear cress, contains 204 amino acids, has 1 CW-type Zinc finger.

CW-type


This is E3 ubiquitin-protein ligase ATL42 protein, from Mouse-ear cress, contains 432 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro

Belongs to the RING-type zinc finger family, ATL subfamily


This is Ubiquitin carboxyl-terminal hydrolase 44-B protein, from African clawed frog, contains 690 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset, Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity)

Belongs to the peptidase C19 family, USP44 subfamily


This is E3 ubiquitin-protein ligase MARCHF8 protein, from African clawed frog, contains 264 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that mediates ubiquitination of cd86 and MHC class II proteins, such as hla-dr alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies


This is E3 ubiquitin-protein ligase synoviolin B protein, from African clawed frog, contains 595 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation, Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins, Also promotes the degradation of normal but naturally short-lived proteins, Protects cells from ER stress-induced apoptosis, Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (By similarity)


This is Matrix remodeling-associated protein 8 protein, from Rat, contains 382 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3, Mediates heterophilic cell-cell interactions in vitro, Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38, Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes, Stimulates formation of primary cilia in chondrocytes, Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway, Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis, Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells, Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK, May play a role in the maturation and maintenance of the blood-brain barrier


This is Cilium assembly protein DZIP1L protein, from Rat, contains 776 amino acids, has 1 C2H2-type Zinc finger.

Involved in primary cilium formation, Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane

Cytoplasm, cytoskeleton, cilium basal body

Belongs to the DZIP C2H2-type zinc-finger protein family


This is Tripartite motif-containing protein 54 protein, from Rat, contains 364 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

May bind and stabilize microtubules during myotubes formation


This is CXXC-type zinc finger protein 5 protein, from Rat, contains 316 amino acids, has 1 CXXC-type Zinc finger.

CXXC-type

May indirectly participate in activation of the NF-kappa-B and MAPK pathways (By similarity), Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest, Involved in myelopoiesis (By similarity), Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (PubMed:19001364), Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (By similarity), May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity), Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)


This is Zinc finger protein 143 protein, from Rat, contains 638 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional activator, Activates the gene for selenocysteine tRNA (tRNAsec), Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters, Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity)

Belongs to the GLI C2H2-type zinc-finger protein family


This is Probable E3 ubiquitin-protein ligase MARCHF10 protein, from Rat, contains 790 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase (Probable), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is E3 ubiquitin-protein ligase Hakai protein, from Chicken, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing


This is E3 ubiquitin-protein ligase RNF185 protein, from Chicken, contains 194 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination, Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation, Protects cells from ER stress-induced apoptosis, Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway, Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity, Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity)


This is Protrudin protein, from Chicken, contains 406 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport, Promotes axonal elongation and contributes to the establishment of neuronal cell polarity, Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner, Contributes to both the formation and stabilization of the tubular ER network, Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections


This is E3 ubiquitin-protein ligase BRE1A protein, from Chicken, contains 984 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively)


This is E3 ubiquitin-protein ligase bre-1 protein, from Caenorhabditis briggsae, contains 828 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B (By similarity), H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (By similarity), Involved in regulating stem cell proliferative fate (By similarity)


This is Carcinoembryonic antigen-related cell adhesion molecule 10 protein, from Mouse, contains 265 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

May interact with other CEACAM proteins on the sperm surface

Belongs to the immunoglobulin superfamily, CEA family


This is Zinc finger protein ZIC 4 protein, from Mouse, contains 341 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical


This is Zinc finger protein 354A protein, from Mouse, contains 572 amino acids, has 13 C2H2-type Zinc finger.

It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Vacuolar protein sorting-associated protein 41 homolog protein, from Caenorhabditis briggsae, contains 898 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways, Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion, The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes, Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine, May mediate the tethering of autophagosomes with lysosomes, Has a role in the negative regulation of apoptosis, Required for uptake of exogenous dsRNA which is used in experimental RNA silencing


This is Protein lin-28 protein, from Caenorhabditis briggsae, contains 237 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Heterochronic protein which controls the choice of stage specific cell fates (By similarity), Regulates the timing of the second larval stage events (L2 events) in the hypodermis (By similarity), May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3 (By similarity), Through this regulatory role, controls the timing of the sexual maturation of the nervous system (By similarity), Plays a role in governing the developmental timing of male tail tip morphogenesis (By similarity), Plays a role in the control of seam cell number and vulval development (By similarity)


This is Raf homolog serine/threonine-protein kinase protein, from Caenorhabditis briggsae, contains 811 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Protein kinase that participates in the induction of vulva and has a role in fertility and viability, Acts downstream of the Ras protein let-60, Required for progression of developing oocytes through the pachytene stage, Positively regulates lifespan upstream of mek-2 and mpk-1

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is Semaphorin-3B protein, from Mouse, contains 748 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons


This is Splicing factor 3A subunit 2 protein, from Mouse, contains 475 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex, Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex, Interacts directly with the duplex formed by U2 snRNA and the intron


This is U1 small nuclear ribonucleoprotein C protein, from Mouse, contains 159 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region

Belongs to the U1 small nuclear ribonucleoprotein C family


This is U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 protein, from Mouse, contains 462 amino acids, has 2 C3H1-type Zinc finger.

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns, Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing, Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes, For U2-type introns, it is selectively and specifically required for the second step of splicing (By similarity)


This is Transcription factor Sp4 protein, from Mouse, contains 782 amino acids, has 3 C2H2-type Zinc finger.

Binds to GT and GC boxes promoters elements, Probable transcriptional activator, Required for normal male reproductive behavior

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase ZFP91 protein, from Mouse, contains 572 amino acids, has 5 C2H2-type Zinc finger.

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK, It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway, May also play an important role in cell proliferation and/or anti-apoptosis


This is Butyrophilin subfamily 1 member A1 protein, from Mouse, contains 524 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

May function in the secretion of milk-fat droplets, May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity), Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Prostaglandin F2 receptor negative regulator protein, from Rat, contains 879 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant, Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity), In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity)


This is Limbic system-associated membrane protein protein, from Rat, contains 338 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates selective neuronal growth and axon targeting, Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system, Essential for normal growth of the hippocampal mossy fiber projection

Belongs to the immunoglobulin superfamily, IgLON family


This is Allergin-1 protein, from Rat, contains 248 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells, Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity)


This is Interleukin-1 receptor-like 2 protein, from Rat, contains 561 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for interleukin-36 (IL36A, IL36B and IL36G), After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways, The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system, Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway, Receptor for the interleukin IL36G, Binding to the agonist leads to the activation of NF-kappa-B (By similarity)

Belongs to the interleukin-1 receptor family


This is Zinc finger protein 260 protein, from Rat, contains 407 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling, Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA, Also acts as a cofactor with GATA4, a key cardiac regulator


This is Zinc-alpha-2-glycoprotein protein, from Rat, contains 296 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers


This is Ras GTPase-activating protein 2 protein, from Rat, contains 847 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Inhibitory regulator of the Ras-cyclic AMP pathway, May bind inositol tetrakisphosphate (IP4) and phospholipids


This is DNA-directed RNA polymerases I, II, and III subunit RPABC4 protein, from Mouse, contains 58 amino acids, has 1 C4-type Zinc finger.

Factor that activates expression from a metal response element of the mouse metallothionein-I gene

Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family


This is Zinc finger protein with KRAB and SCAN domains 2 protein, from Human, contains 967 amino acids, has 6 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Hepatic and glial cell adhesion molecule protein, from Mouse, contains 418 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Involved in regulating cell motility and cell-matrix interactions, May inhibit cell growth through suppression of cell proliferation (By similarity)


This is Tripartite motif-containing protein 72 protein, from Western clawed frog, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites, Specifically binds phosphatidylserine, Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site, This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation, Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity)


This is T-cell surface glycoprotein CD3 gamma chain protein, from Rat, contains 182 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways, In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface, Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G


This is FMR1-interacting protein NUFIP1 protein, from Rat, contains 486 amino acids, has 1 C2H2-type Zinc finger.


This is Peroxynitrite isomerase THAP4 protein, from Rat, contains 569 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate, Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively), Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region

In the C-terminal section; belongs to the nitrobindin family


This is Zinc-alpha-2-glycoprotein protein, from Mouse, contains 307 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Transcription factor Sp9 protein, from Mouse, contains 484 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor which plays a key role in limb development, Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos


This is RNA-binding protein 4B protein, from Rat, contains 357 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for the translational activation of PER1 mRNA in response to circadian clock, Binds directly to the 3'-UTR of the PER1 mRNA (By similarity)


This is Nuclear hormone receptor family member nhr-76 protein, from Caenorhabditis elegans, contains 480 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor (By similarity), Involved in modulating serotonin-mediated induction of adipose triglyceride lipase atgl-1, thereby regulating body fat (PubMed:24120942)

Belongs to the nuclear hormone receptor family


This is Formamidopyrimidine-DNA glycosylase protein, from Mannheimia succiniciproducens (strain MBEL55E), contains 270 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is E3 ubiquitin-protein ligase XB3 protein, from Rice, contains 450 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for full accumulation of the LRR receptor kinase XA21 and XA21-mediated disease resistance, Binding to XA21 may stabilize the receptor kinase and maintain its protein level, Autoubiquitinated in vitro


This is Replication protein A 70 kDa DNA-binding subunit C protein, from Rice, contains 951 amino acids, has 1 C4-type Zinc finger.

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication, The activity of RPA is mediated by single-stranded DNA binding and protein interactions, Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity)

Belongs to the replication factor A protein 1 family


This is Kruppel-like factor 3 protein, from Caenorhabditis elegans, contains 315 amino acids, has 3 C2H2-type Zinc finger.

Probable transcription factor which regulates lipid catabolism, storage, and secretion, probably by modulating genes involved in fatty acid desaturation and beta-oxidation, and lipoprotein assembly and secretion (PubMed:19427851, PubMed:23639358), Involved in reproduction, perhaps indirectly (PubMed:19427851, PubMed:23639358)


This is F-box only protein 43 protein, from Rat, contains 664 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization, Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase, Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (By similarity), Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis


This is tRNA endonuclease ANKZF1 protein, from Rat, contains 722 amino acids, has 1 C2H2-type Zinc finger.

Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation, The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts, ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs, ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1, Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress


This is ARF GTPase-activating protein GIT2 protein, from Rat, contains 759 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1


This is Tax1-binding protein 1 homolog protein, from Rat, contains 813 amino acids, has 2 UBZ1-type Zinc finger.

Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation, Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates, Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production, Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways, Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling, As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis, Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation


This is Probable ATP-dependent RNA helicase DDX59 protein, from Rat, contains 589 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Belongs to the DEAD box helicase family, DDX59 subfamily


This is E3 ubiquitin-protein ligase RING2-A protein, from African clawed frog, contains 344 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation, H2AK119Ub gives a specific tag for epigenetic transcriptional repression, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility


This is E3 ubiquitin-protein ligase arkadia-C protein, from African clawed frog, contains 967 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity), Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP, Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP, Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity), The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity)


This is E3 ubiquitin-protein ligase rnf146 protein, from Western clawed frog, contains 316 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins, Neuroprotective protein, Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest, Promotes cell survival after gamma-irradiation, Facilitates DNA repair


This is Protein odd-skipped-related 1 protein, from Western clawed frog, contains 259 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional repressor (By similarity), Required for pronephric kidney development

Belongs to the Odd C2H2-type zinc-finger protein family


This is Nuclear receptor subfamily 6 group A member 1 protein, from Western clawed frog, contains 435 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Probable orphan nuclear receptor, Binds to a response element containing repeats of the motif 5'-AGGTCA-3', Required for anterior-posterior patterning during organogenesis, Acts with chordin to play a role in patterning the midbrain-hindbrain, Isoform Em is required for integrin-mediated cell matrix interaction during neurulation and for the morphogenetic movements leading to formation of the neural tube, Also mediates the effect of retinoic acid on primary neurogenesis (By similarity)

Belongs to the nuclear hormone receptor family, NR6 subfamily


This is Zinc finger protein 385C protein, from Human, contains 422 amino acids, has 3 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type


This is Protein FAM170A protein, from Mouse, contains 333 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes, Binds to heat shock promoter elements (HSE)


This is E3 ubiquitin-protein ligase RNF113A protein, from Bovine, contains 343 amino acids, has 1 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

Required for pre-mRNA splicing as component of the spliceosome, As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity), E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins, Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains, Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents, Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling


This is Formamidopyrimidine-DNA glycosylase protein, from Symbiobacterium thermophilum (strain T / IAM 14863), contains 305 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Ubiquitin carboxyl-terminal hydrolase 18 protein, from Mouse-ear cress, contains 631 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin, Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)


This is Zinc finger protein 626 protein, from Human, contains 528 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 10 C2H2-type Zinc finger, has 1 C2H2-type 12; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 12; degenerate

May be involved in transcriptional regulation


This is E3 ubiquitin-protein ligase rnf152-B protein, from African clawed frog, contains 203 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation, Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability, Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation


This is Zinc finger protein 280D protein, from Mouse, contains 974 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate


This is Pleckstrin homology domain-containing family F member 1 protein, from Rat, contains 279 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May induce apoptosis through the lysosomal-mitochondrial pathway, Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm, Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity)


This is E3 ubiquitin-protein ligase MIB2 protein, from Rat, contains 971 amino acids, has 1 ZZ-type Zinc finger, has 2 RING-type Zinc finger.

ZZ-type

RING-type

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins, Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors