This is Gag polyprotein protein, from SIV-sm, contains 507 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1


This is Wilms tumor protein protein, from Human, contains 449 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533), Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363), Regulates the expression of numerous target genes, including EPO, Plays an essential role for development of the urogenital system, It has a tumor suppressor as well as an oncogenic role in tumor formation, Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190), Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801), Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921)

Belongs to the EGR C2H2-type zinc-finger protein family


This is Gag polyprotein protein, from BIV, contains 476 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA, Binds these RNAs through its zinc fingers (By similarity)

Belongs to the bovine lentivirus group gag polyprotein family


This is Estrogen receptor protein, from Mouse, contains 599 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP, Can activate the transcriptional activity of TFF1, Also mediates membrane-initiated estrogen signaling involving various kinase cascades, Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Retinoic acid receptor RXR-alpha protein, from Human, contains 462 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid that acts as a transcription factor (PubMed:11162439, PubMed:11915042), Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:28167758, PubMed:17761950, PubMed:16107141, PubMed:18800767, PubMed:19167885), The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758), The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260), In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566), On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:9267036), Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580), The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580), The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690), Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758), Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758), May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776), Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675), Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649), Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is HLA class II histocompatibility antigen, DP alpha 1 chain protein, from Human, contains 260 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells, The peptide binding cleft accommodates peptides of 10-30 residues, The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases, Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous, As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components, Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments, In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract, To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer, Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide), The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released, HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound, The MHC II molecule bound to a peptide is then transported to the cell membrane surface, In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO, Primary dendritic cells (DCs) also to express HLA-DO, Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading


This is Rano class II histocompatibility antigen, B alpha chain protein, from Rat, contains 256 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Eukaryotic translation initiation factor 2 subunit 2 protein, from Human, contains 333 amino acids, has 1 C4-type Zinc finger.

Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC), Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex, In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B


This is Meiosis-specific protein HOP1 protein, from Baker's yeast, contains 605 amino acids, has 1  Zinc finger.

Probable constituent of the synaptonemal complex during meiosis, May interact with RED1


This is Myeloid cell surface antigen CD33 protein, from Human, contains 364 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212), Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872), Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109), These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109), In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109), One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323)

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is Protein ultraspiracle protein, from Fruit fly, contains 508 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone, May be an important modulator of insect metamorphosis, Plays an important part in embryonic and post-embryonic development, Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene


This is Diacylglycerol kinase alpha protein, from Pig, contains 734 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:8034597), Also plays an important role in the biosynthesis of complex lipids, Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group, Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (By similarity)

Belongs to the eukaryotic diacylglycerol kinase family


This is B-cell receptor CD22 protein, from Human, contains 847 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates B-cell B-cell interactions, May be involved in the localization of B-cells in lymphoid tissues, Binds sialylated glycoproteins; one of which is CD45, Preferentially binds to alpha-2,6-linked sialic acid, The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface, Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling, Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules


This is Chorion transcription factor Cf2 protein, from Fruit fly, contains 510 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional regulator; binds to the promoter region of Cp15, Also binds to its own promoter, thus having a probable autoregulatory role


This is Nuclear receptor subfamily 1 group D member 1 protein, from Human, contains 614 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1, Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis, Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis, Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG, Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells, Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1, Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway, Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep, In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function, In addition to its activity as a repressor, can also act as a transcriptional activator, In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis, In collaboration with SP1, activates GJA1 transcription in a heme-independent manner, Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity), Represses the transcription of CES2 (By similarity), Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity), Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity), Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity), Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity), Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Protein kinase C alpha type protein, from Mouse, contains 672 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP, Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle, Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation, In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B, Depending on the cell type, exhibits anti-apoptotic function and protects cells from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, or mediates anti-apoptotic action by phosphorylating BCL2, During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development, After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion, Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility, During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (By similarity), Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries, Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area, Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility, In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation, Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation, In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion, During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation, But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA), Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation, Phosphorylates KIT, leading to inhibition of KIT activity, Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription, Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (PubMed:31578312)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is High affinity immunoglobulin epsilon receptor subunit alpha protein, from Mouse, contains 250 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

High-affinity receptor for immunoglobulin epsilon/IgE, Mediates IgE effector functions in myeloid cells, Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation, On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes, Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity, When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions


This is Gag polyprotein protein, from HIV-1, contains 504 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Gag polyprotein protein, from HIV-2, contains 521 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-1, contains 499 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Myelin-associated glycoprotein protein, from Human, contains 626 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity), Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination, Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2, Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity), Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides, In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides, In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides, Inhibits axon longitudinal growth (By similarity), Inhibits axon outgrowth by binding to RTN4R (By similarity), Preferentially binds to alpha-2,3-linked sialic acid, Binds ganglioside Gt1b (By similarity)


This is Myelin-associated glycoprotein protein, from Mouse, contains 627 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:7533044, PubMed:12089450, PubMed:27922006), Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination (PubMed:7516497, PubMed:9262180, PubMed:9482781, PubMed:9482783, PubMed:9469574, PubMed:10625334), Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2 (PubMed:26335717), Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (PubMed:15953602, PubMed:19158290), Negative regulator of neurite outgrowth that inhibits axon longitudinal growth (PubMed:19158290, PubMed:27922006, PubMed:12089450), Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868), In cerebellar granule cells the inhibition is mediated via binding to neuronal gangliosides (PubMed:17640868), In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (By similarity), Inhibits axon outgrowth by binding to RTN4R (PubMed:12089450), Preferentially binds to alpha-2,3-linked sialic acid (PubMed:7533044, PubMed:27922006), Binds ganglioside Gt1b (PubMed:27922006)


This is Metallothionein expression activator protein, from Baker's yeast, contains 770 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 3; atypical

Plays a role in regulating basal-level expression of CUP1, Activates EGT2 transcription in the absence of SWI5


This is Cyclin-dependent kinase inhibitor FAR1 protein, from Baker's yeast, contains 830 amino acids, has 1 RING-type Zinc finger.

RING-type

Inhibitor of the cyclin-dependent kinase CDC28, Necessary for cell cycle arrest, Involved in pheromone response, Contributes to mating efficiency, Required for oriented polarization of yeast cells in response to mating pheromones


This is Gag polyprotein protein, from GALV, contains 520 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome, Binds with high affinity to conserved elements within the packaging signal, located near the 5'-end of the genome, This binding is dependent on genome dimerization


This is Gag polyprotein protein, from HoMuLV, contains 540 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome, Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome, This binding is dependent on genome dimerization


This is E3 ubiquitin-protein ligase sina protein, from Fruit fly, contains 314 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk) (PubMed:9267026, PubMed:9267027, PubMed:11526076, PubMed:12215542, PubMed:18160715), E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:12215542), Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons (PubMed:9267026, PubMed:9267027, PubMed:11526076, PubMed:12215542), Also involved in external sensory organ development (PubMed:11526076)

Belongs to the SINA (Seven in absentia) family


This is Tumor necrosis factor alpha-induced protein 3 protein, from Human, contains 790 amino acids, has 7 A20-type Zinc finger.

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity, Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways, In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3, In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3, Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains, This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B, Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin, Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation, Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation, Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2, Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation, Targets TRAF2 for lysosomal degradation, In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains, Inhibitor of programmed cell death, Has a role in the function of the lymphoid system, Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages


This is DNA-directed RNA polymerase 30 kDa polypeptide protein, from VACV, contains 259 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates, Responsible for the transcription of early, intermediate and late genes, DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG134, thereby allowing the early genes transcription, Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase

Belongs to the poxviridae DNA-directed RNA polymerase 30 kDa subunit family


This is Beta-2-microglobulin protein, from Chicken, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system

Belongs to the beta-2-microglobulin family


This is V(D)J recombination-activating protein 2 protein, from Mouse, contains 527 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical

Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination, V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments, DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends, The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps, The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes, The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele, In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1, It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3


This is Fibroblast growth factor receptor 2 protein, from Human, contains 821 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development, Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development, Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development, Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts, Phosphorylates PLCG1, FRS2 and PAK4, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation, Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling, Over-expressed FGFR2 promotes activation of STAT1

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Fibroblast growth factor receptor 2 protein, from Mouse, contains 821 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Fibroblast growth factor receptor 1 protein, from Chicken, contains 819 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration, Required for normal mesoderm patterning and normal skeletogenesis, Phosphorylates PLCG1, FRS2, GAB1 and SHB, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2, In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription, FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity)


This is Embigin protein, from Mouse, contains 330 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity), Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions, Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology, Delays the retraction of terminal sprouts following re-innervation of denervated endplates


This is Fibroblast growth factor receptor 1 protein, from African clawed frog, contains 812 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Mineralocorticoid receptor protein, from Rat, contains 981 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol, Binds to mineralocorticoid response elements (MRE) and transactivates target genes, The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels


This is Zinc finger protein 42 protein, from Mouse, contains 288 amino acids, has 4 C2H2-type Zinc finger.

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency, Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST, Binds DXPas34 enhancer within the TSIX promoter, Involved in ES cell self-renewal

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Protein teashirt protein, from Fruit fly, contains 954 amino acids, has 3 C2H2-type Zinc finger.

Homeotic protein that acts downstream of Arm in the Wg cascade during embryogenesis to determine segment identity throughout the entire trunk, Acts cooperatively with other trunk homeotic proteins to repress head homeotic genes and therefore repress head segmental identity, Necessary, in combination with Scr, for the formation of the prothoracic segment, Promotes eye development in the dorsal region of the eye disk and suppresses eye development in the ventral region in combination with Wg-signaling and several early dorso-ventral eye patterning genes, Required for proper development of proximal leg segments, Has differential functions along the dorso-ventral axs of the antennal and leg disks, May play a role in wing hinge development, Possible involvement in chromatin structure for modulation of transcription, Binds DNA and can act as both a transcriptional repressor and activator, Positively regulates its own expression as well as that of Dll, Negatively regulates the expression of mod, Required for Wg-mediated transcriptional repression of Ubx in the midgut, Also represses transcription of lab in the midgut and is necessary for the proper formation of anterior and central midgut structures, Tiptop (tio) and teashirt (tsh) have, on the whole, common activities, Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop, Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg

Belongs to the teashirt C2H2-type zinc-finger protein family


This is Interleukin-6 receptor subunit alpha protein, from Mouse, contains 460 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:11113088), The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling', sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (By similarity), In complex with IL6, is required for induction of VEGF production (By similarity), Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088), 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851)

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Interleukin-6 receptor subunit alpha protein, from Rat, contains 462 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (By similarity), The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling', sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases, In complex with IL6, is required for induction of VEGF production (By similarity), Plays a protective role during liver injury, being required for maintenance of tissue regeneration, 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity)


This is Replication factor A protein 1 protein, from Baker's yeast, contains 621 amino acids, has 1 C4-type Zinc finger.

As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair, Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism, Binds to single-stranded sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation (CAR1), Stimulates the activity of a cognate strand exchange protein (SEP1), It cooperates with T-AG and DNA topoisomerase I to unwind template DNA containing the simian virus 40 origin of DNA replication

Belongs to the replication factor A protein 1 family


This is Gag polyprotein protein, from SIV-mnd, contains 502 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1


This is Retinoic acid receptor beta protein, from Chicken, contains 455 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), Required for limb and craniofacial development


This is Hepatocyte nuclear factor 4-alpha protein, from Rat, contains 474 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (By similarity), Activates the transcription of CYP2C38 (By similarity), Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (By similarity)


This is Fibroblast growth factor receptor 4 protein, from Human, contains 802 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis, Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19, Phosphorylates PLCG1 and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4, Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling


This is Wilms tumor protein homolog protein, from Mouse, contains 449 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor that plays an important role in cellular development and cell survival (PubMed:16467207, PubMed:16920711, PubMed:17537799), Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity), Regulates the expression of numerous target genes, including EPO (PubMed:16467207), Plays an essential role for development of the urogenital system, It has a tumor suppressor as well as an oncogenic role in tumor formation, Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors, Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:17167543), Isoform 1 has lower affinity for DNA, and can bind RNA

Belongs to the EGR C2H2-type zinc-finger protein family


This is Retinoic acid receptor beta protein, from Mouse, contains 482 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity), The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity), In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355)


This is Fibroblast growth factor receptor 3 protein, from Human, contains 806 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis, Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development, Regulates both osteogenesis and postnatal bone mineralization by osteoblasts, Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation, Required for normal development of the inner ear, Phosphorylates PLCG1, CBL and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Plays a role in the regulation of vitamin D metabolism, Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling, Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B, Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling


This is T-cell surface glycoprotein CD3 epsilon chain protein, from Mouse, contains 189 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways, In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (PubMed:19956738, PubMed:24899501), Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region


This is E3 ubiquitin-protein ligase CBL protein, from Human, contains 906 amino acids, has 1 RING-type Zinc finger.

RING-type

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors, Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:17094949), Ubiquitinates SPRY2 (PubMed:17094949, PubMed:17974561), Ubiquitinates EGFR (PubMed:17974561), Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and terminates signaling, Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation, Participates in signal transduction in hematopoietic cells, Plays an important role in the regulation of osteoblast differentiation and apoptosis, Essential for osteoclastic bone resorption, The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3, In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity)


This is E3 ubiquitin-protein ligase CBL protein, from Mouse, contains 913 amino acids, has 1 RING-type Zinc finger.

RING-type

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors, Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome, Ubiquitinates SPRY2 (By similarity), Ubiquitinates EGFR (By similarity), Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling, Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation, Participates in signal transduction in hematopoietic cells, Plays an important role in the regulation of osteoblast differentiation and apoptosis, Essential for osteoclastic bone resorption, The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3 (PubMed:10393178, PubMed:12649282, PubMed:19265199, PubMed:20100865, PubMed:9653117), In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719)


This is Nuclear receptor subfamily 4 group A member 1 protein, from Human, contains 598 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration, Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity), May inhibit NF-kappa-B transactivation of IL2, Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation, Plays a role in the vascular response to injury (By similarity)

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is Nuclear receptor subfamily 4 group A member 1 protein, from Rat, contains 597 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration, Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3', May inhibit NF-kappa-B transactivation of IL2, Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity), Plays a role in the vascular response to injury (By similarity)


This is mRNA decay activator protein ZFP36 protein, from Mouse, contains 319 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10706852, PubMed:10805719, PubMed:15014438, PubMed:15187092, PubMed:15634918, PubMed:17030620, PubMed:19188452, PubMed:20595389, PubMed:21078877, PubMed:22701344, PubMed:27193233), Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:21278420), Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:21278420), Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:21278420), Self regulates by destabilizing its own mRNA (PubMed:15187092, PubMed:17288565), Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:11533235, PubMed:15187092, PubMed:16508014, PubMed:17288565, PubMed:17971298, PubMed:20595389, PubMed:21078877, PubMed:21278420, PubMed:22701344, PubMed:27193233), Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (PubMed:8630730, PubMed:9703499, PubMed:15014438, PubMed:16514065), Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (By similarity), Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (By similarity), Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344), Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (By similarity), Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (PubMed:25815583), Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (By similarity), Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (By similarity), May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (By similarity), Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (By similarity), In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (PubMed:22844456), Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (PubMed:22844456), Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811), Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (By similarity), Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (By similarity)


This is DNA repair protein complementing XP-A cells protein, from Human, contains 273 amino acids, has 1  Zinc finger.

Involved in DNA excision repair, Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region, Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation


This is Immunoglobulin heavy variable 1-2 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is H-2 class II histocompatibility antigen, I-E alpha chain protein, from Mouse, contains 254 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Transcription elongation factor A protein 1 protein, from Human, contains 301 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus


This is Peroxisome proliferator-activated receptor alpha protein, from Mouse, contains 468 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Key regulator of lipid metabolism, Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC), Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety, Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the ACOX1 and P450 genes, Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2, May be required for the propagation of clock information to metabolic pathways regulated by PER2


This is Protein kinase C eta type protein, from Mouse, contains 683 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells, In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation, Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes, In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation, In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement, Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs, In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation, Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1, Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation, In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis, Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria, Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization


This is Diacylglycerol kinase alpha protein, from Human, contains 735 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:2175712, PubMed:15544348), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:2175712, PubMed:15544348), Also plays an important role in the biosynthesis of complex lipids (Probable), Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (PubMed:15544348), Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129)


This is Endothelial transcription factor GATA-2 protein, from Human, contains 480 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells, Binds to the consensus sequence 5'-AGATAG-3'


This is Trans-acting T-cell-specific transcription factor GATA-3 protein, from Human, contains 443 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes, Binds to the consensus sequence 5'-AGATAG-3', Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses, Positively regulates ASB2 expression (By similarity), Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33, Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages


This is Trans-acting T-cell-specific transcription factor GATA-3 protein, from Mouse, contains 443 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes, Binds to the consensus sequence 5'-AGATAG-3', Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses, Positively regulates ASB2 expression (PubMed:31175139), Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33, Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages


This is Protein disconnected protein, from Fruit fly, contains 568 amino acids, has 2 C2H2-type Zinc finger.

Required for the establishment of stable connections between the larval optic nerves, the Bolwig's nerves, and their target cells in the brain during embryonic development


This is Polycomb group RING finger protein 2 protein, from Mouse, contains 342 amino acids, has 1 RING-type Zinc finger.

RING-type

Transcriptional repressor (PubMed:8521824), Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824), Has tumor suppressor activity (PubMed:8521824), May play a role in control of cell proliferation and/or neural cell development (Probable), Regulates proliferation of early T progenitor cells by maintaining expression of HES1(PubMed:15728456), Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:8625838, PubMed:15183898), Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity)


This is Protein odd-skipped protein, from Fruit fly, contains 392 amino acids, has 4 C2H2-type Zinc finger.

Pair-rule protein that determines both the size and polarity of even-numbered as well as odd-numbered parasegments during embryogenesis, DNA-binding transcription factor that acts primarily as a transcriptional repressor but can also function as a transcriptional activator, depending on the stage of development and spatial restrictions, May function redundantly with odd and drm in leg joint formation during the larval stages, acting downstream of Notch activation

Belongs to the Odd C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase Mdm2 protein, from Mouse, contains 489 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:15195100, PubMed:21804542), Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity), Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2 (PubMed:11588219), Permits the nuclear export of p53/TP53 (By similarity), Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein (By similarity), Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation (By similarity), Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53 (By similarity), Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways (By similarity), Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus (By similarity), Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (By similarity), Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (PubMed:25088421), Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (PubMed:14642282), Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903), Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903)


This is GATA-binding factor 3 protein, from Chicken, contains 444 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator which probably serves as a general switch factor for cell-specific development, It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes


This is mRNA decay activator protein ZFP36L2 protein, from Mouse, contains 484 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:22701344, PubMed:22367205, PubMed:25505318, PubMed:24830504, PubMed:27102483), Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity), Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity), Binds to 3'-UTR ARE of numerous mRNAs (PubMed:22701344, PubMed:22367205, PubMed:25505318, PubMed:24830504), Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (By similarity), Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344), Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA (PubMed:25505318), Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA (PubMed:24830504), Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation (PubMed:19633199, PubMed:23748442), In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation (PubMed:27102483), Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (PubMed:20622884)


This is mRNA decay activator protein ZFP36L1 protein, from Mouse, contains 338 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:22701344, PubMed:24700863, PubMed:24733888, PubMed:27102483), Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity), Functions by recruiting the CCR4-NOT deadenylating complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity), Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity), Binds to 3'-UTR ARE of numerous mRNAs (PubMed:22701344, PubMed:24700863, PubMed:24733888), Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344), Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863), Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (By similarity), Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (By similarity), Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (PubMed:24733888), May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (By similarity), In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (PubMed:27102483), Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (PubMed:20622884), Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (By similarity), In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (By similarity), Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity), Plays a role in vasculogenesis and endocardial development (PubMed:15226444, PubMed:17013884), Involved in the regulation of keratinocyte proliferation, differentiation and apoptosis (By similarity), Plays a role in myoblast cell differentiation (PubMed:17889962)


This is Immunoglobulin alpha Fc receptor protein, from Human, contains 287 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Binds to the Fc region of immunoglobulins alpha, Mediates several functions including cytokine production


This is Gag polyprotein protein, from HIV-2, contains 521 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1


This is Zinc finger and BTB domain-containing protein 25 protein, from Human, contains 435 amino acids, has 2 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Peroxisome biogenesis factor 2 protein, from Rat, contains 305 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:1750930), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane, PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase, PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity), Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70, Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (By similarity)


This is COUP transcription factor 2 protein, from Human, contains 414 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro), Regulation of the apolipoprotein A-I gene transcription, Binds to DNA site A, May be required to establish ovary identity during early gonad development (PubMed:29478779)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is DNA repair protein RadA protein, from Escherichia coli (strain K12), contains 460 amino acids, has 1 C4-type Zinc finger.

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks, Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster, Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB, Does not have RecA's homology-searching function (PubMed:26845522), Genetic experiments involving combination of radA mutations with mutations in recA, recB, recG, recJ, recQ, ruvA and ruvC show it plays a role in recombination and recombinational repair, probably involving stabilizing or processing branched DNA or blocked replication forks, Is genetically synergistic to RecG and RuvABC (PubMed:12446634, PubMed:25484163), May be involved in recovery of genetic rearrangements during replication fork breakdown (PubMed:16904387), In combination with RadD is important in recovery from double-strand DNA breaks (DSB) (PubMed:25425430)

Belongs to the RecA family, RadA subfamily


This is Tyrosine-protein kinase Tec protein, from Mouse, contains 630 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton, Plays a redundant role to ITK in regulation of the adaptive immune response, Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells, Required for TCR-dependent IL2 gene induction, Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling, Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking, Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein, Required in mast cells for efficient cytokine production, Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells, Participates in platelet signaling downstream of integrin activation, Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription, GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC, TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets, Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway, TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-82', May also be involved in the regulation of osteoclast differentiation

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Protein kinase C eta type protein, from Human, contains 683 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells, In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation, Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes, In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation, In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement, Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs, In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation, Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1, Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation, In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis, Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria, Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization


This is Gag polyprotein protein, from HIV-1, contains 493 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is NT-3 growth factor receptor protein, from Pig, contains 825 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in nervous system and probably heart development, Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is Gag polyprotein protein, from BLV, contains 392 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Binds strongly to viral nucleic acids and promote their aggregation, Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs


This is Myelin protein P0 protein, from Human, contains 248 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system, It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction


This is DnaJ-related protein SCJ1 protein, from Baker's yeast, contains 377 amino acids, has 1 CR-type Zinc finger.

CR-type

Regulates protein folding in the endoplasmic reticulum lumen, Probably acts as a J-protein for the Hsp70-type chaperone KAR2 by stimulating its ATP-dependent reaction cycle and initiating folding reactions, Also involved in the endoplasmic reticulum-associated degradation (ERAD) process, Cooperates with KAR2 and another J-protein JEM1 to facilitate the export of ERAD substrates to the cytoplasm by maintaining them in a translocation-competent state and preventing their aggregation in the endoplasmic reticulum lumen


This is Zinc-alpha-2-glycoprotein protein, from Human, contains 298 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers, May bind polyunsaturated fatty acids


This is Transcriptional repressor protein YY1 protein, from Human, contains 414 amino acids, has 4 C2H2-type Zinc finger.

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements

Belongs to the YY transcription factor family


This is Mitochondrial protein import protein MAS5 protein, from Baker's yeast, contains 409 amino acids, has 1 CR-type Zinc finger.

CR-type

Probably involved in mitochondrial protein import, Is also required for efficient translocation of pre-pro-alpha-factor, Involved in heme regulation of HAP1, as a component of the high-molecular-weight (HMC) complex


This is Protein nanos protein, from Fruit fly, contains 401 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type

Maternal RNA-binding protein that is required for germ cells proliferation and self-renewal, Acts by forming a complex with pum and brat that regulates translation and mRNA stability, The complex binds to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation, Controls posterior development, Rescuing factor for the abdominal defect of posterior group mutants, The other posterior group genes are not required for nanos function but rather play a role in localization or distribution of nanos protein

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is Polycomb complex protein BMI-1 protein, from Mouse, contains 324 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A, In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity)


This is B-lymphocyte antigen CD19 protein, from Mouse, contains 547 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes, Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity), Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:12387743, PubMed:20101619), Is not required for early steps during B cell differentiation in the blood marrow (PubMed:7542548, PubMed:7543183, PubMed:9317126), Required for normal differentiation of B-1 cells (PubMed:7542548, PubMed:7543183, PubMed:12387743), Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:7542548, PubMed:9317126, PubMed:12387743), Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:7542548, PubMed:7543183, PubMed:12387743)


This is Protein escargot protein, from Fruit fly, contains 470 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; atypical Zinc finger.

C2H2-type 5; atypical

Transcription factor that can both stimulate and repress transcription, Binds to the consensus DNA sequence 5'-A/GCAGGTG-3', Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion, Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication, Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate, The somatic protein is required for maintenance of male germ cells, Acts with other members of the snail protein family to control embryonic central nervous system development

Belongs to the snail C2H2-type zinc-finger protein family


This is High affinity immunoglobulin gamma Fc receptor I protein, from Mouse, contains 404 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

High affinity receptor for the Fc region of immunoglobulins gamma, Functions in both innate and adaptive immune responses

Belongs to the immunoglobulin superfamily, FCGR1 family


This is Basigin protein, from Rat, contains 388 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Ig-like V-type

Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity), Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1 and SLC16A3 to the plasma membrane (PubMed:10921872), Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity), Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity), Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (By similarity)


This is Early growth response protein 1 protein, from Zebrafish, contains 511 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator (PubMed:7945937), Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity), Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity), Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia, Plays a role in the regulation of cell survival, proliferation and cell death, Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity), Plays a role in regulating the expression of circadian clock genes (By similarity)


This is E3 SUMO-protein ligase EGR2 protein, from Chinese hamster, contains 62 amino acids, has 3 C2H2-type Zinc finger.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity


This is E3 SUMO-protein ligase EGR2 protein, from Crab-eating fox, contains 62 amino acids, has 3 C2H2-type Zinc finger.


This is mRNA decay activator protein ZFP36 protein, from Human, contains 326 amino acids, has 2 C3H1-type Zinc finger.

(Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter


This is Gag polyprotein protein, from FrMLV, contains 538 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome, Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome, This binding is dependent on genome dimerization


CCHC-type


This is Gag polyprotein protein, from FrMLV, contains 539 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Ciliary neurotrophic factor receptor subunit alpha protein, from Human, contains 372 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to CNTF, The alpha subunit provides the receptor specificity, Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303), Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1 (PubMed:19386761)


This is Gag polyprotein protein, from Cas-Br-E murine leukemia virus, contains 536 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Myelin protein P0 protein, from Mouse, contains 248 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Low affinity immunoglobulin gamma Fc region receptor III protein, from Rat, contains 267 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the Fc region of complexed immunoglobulins gamma (PubMed:1692135), Low affinity receptor which binds to IgG1, IgG2a and IgG2b (By similarity), Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (By similarity)


This is Replication protein A 70 kDa DNA-binding subunit protein, from Human, contains 616 amino acids, has 1 C4-type Zinc finger.

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress, It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717), Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682), In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation, Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808), It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923), Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716), Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279), Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage, Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620), As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair, Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase, The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105)


This is Regulatory protein MIG1 protein, from Baker's yeast, contains 504 amino acids, has 2 C2H2-type Zinc finger.

Involved in glucose repression of the SUC, GAL and MAL genes as well as of the CAT8 gene, Binds to two sites in the upstream region of SUC2

Belongs to the creA/MIG C2H2-type zinc-finger protein family


This is Vacuolar membrane protein PEP3 protein, from Baker's yeast, contains 918 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole, Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes, Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion, HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly, It remains bound to SNARE complexes after vacuole fusion