This is E4 SUMO-protein ligase PIAL1 protein, from Mouse-ear cress, contains 847 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

E4-type SUMO ligase that promotes SUMO chain formation in a SCE1-dependent manner and thus contributes to a pathway for proteolytic removal of sumoylation substrates, Involved in stress responses (e,g, osmotic, salt and abscisic acid ABA) and sulfur metabolism

Belongs to the PIAL protein ligase family


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Mouse, contains 249 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:16039578), Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417), Can bind to IgG2a and IgG2b monomers (PubMed:18949059), Does not display binding to IgG1 or IgG3 (PubMed:16039578), Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC), Confers protection to lethal influenza virus infection (PubMed:24412922), On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (PubMed:28389502), Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (PubMed:18097064), Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719), Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE) (PubMed:17558411, PubMed:18949059), Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059), Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411), Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059), Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059), Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821)


This is Tripartite motif-containing protein 46 protein, from Rat, contains 759 amino acids, has 1 RING-type 1; degenerate Zinc finger, has 1 RING-type 2; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type 1; degenerate

RING-type 2; degenerate

B box-type

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon, Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons, Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration


This is DNA-dependent metalloprotease SPRTN protein, from Zebrafish, contains 636 amino acids, has 1 UBZ4-type Zinc finger.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (By similarity), DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde, Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis, Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4 (By similarity), Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs, SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity), May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis, Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage (By similarity)


This is Protein CD300H protein, from Human, contains 201 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play an important role in innate immunity by mediating a signal for the production of a neutrophil chemoattractant


This is Junctional adhesion molecule 2A protein, from Zebrafish, contains 307 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Junctional adhesion protein that mediates heterotypic cell-cell interactions to regulate different cellular processes (By similarity), During myogenesis, it is involved in myocyte fusion through the binding of jam3b on neighboring myocytes (PubMed:22180726)

Belongs to the immunoglobulin superfamily


This is Zinc finger protein 16-like protein, from Zebrafish, contains 528 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger.

C2H2-type 6; degenerate

Probable transcription factor (Probable), Important for development and migration of oligodendrocyte precursor cells, and normal myelination of axons in the central nervous system (CNS) (PubMed:26459222), Functions autonomously in oligodendrocytes to promote CNS myelination (PubMed:26459222), Seems to act in parallel with notch3 during oligodendrocyte development (PubMed:26459222)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is DEAD-box ATP-dependent RNA helicase 3B, chloroplastic protein, from Maize, contains 743 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Nuclear genome-encoded factor involved in ribosome biogenesis in chloroplasts, Binds specific group II introns in chloroplasts and facilitates their splicing, Is required for rRNA maturation in plastids and may contribute to the assembly of the large (50S) ribosomal subunit, Required for normal development of chloroplasts

Belongs to the DEAD box helicase family, DDX21/DDX50 subfamily


This is DNA-dependent metalloprotease SPRTN protein, from African clawed frog, contains 565 amino acids, has 2 UBZ4-type Zinc finger.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:30595436), DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (By similarity), Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (By similarity), Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4 (By similarity), Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs (PubMed:30595436), SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (PubMed:30595436), May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis (By similarity), Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage (By similarity)


This is Endonuclease 8-like 3 protein, from African clawed frog, contains 616 amino acids, has 1 FPG-type Zinc finger, has 1 RanBP2-type Zinc finger, has 2 GRF-type Zinc finger.

FPG-type

GRF-type

GRF-type

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:30842657), Mediates interstrand cross-link repair in response to replication stress: recruited to replication stress sites via interaction with ubiquitinated CMG helicase and acts by mediating DNA glycosylase activity (PubMed:30842657), Cleaves one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (PubMed:30842657)


This is PHD finger protein 14 protein, from Zebrafish, contains 914 amino acids, has 4 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

PHD-type

PHD-type

Histone-binding protein (PubMed:34365506), Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (PubMed:34365506), Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity)


This is Zinc finger protein syd-9 protein, from Caenorhabditis elegans, contains 554 amino acids, has 4 C2H2-type Zinc finger.

Plays a role in regulating synaptic function, probably by modulation of endocytosis (PubMed:16803962), May be dispensable in muscle for normal locomotion (PubMed:16803962), May be involved in post-transcriptional mRNA processing, in parallel with unc-75 (PubMed:16803962)


This is FLYWCH-type zinc finger-containing protein peb-1 protein, from Caenorhabditis elegans, contains 443 amino acids, has 1 FLYWCH-type Zinc finger.

FLYWCH-type

Putative transcription factor (PubMed:11203704), Binds to specific sequence motif 5'-[TC][AGT]TGCC[GA][AT]-3' in regulatory elements of target genes such as myosin myo-2 (PubMed:11203704, PubMed:15165844), May modulate gene expression, perhaps acting in opposition to transcription factor pha-4 (PubMed:11203704, PubMed:12095247), Involved in morphogenesis, perhaps especially in formation of the pharynx (PubMed:11203704, PubMed:15581870), Plays roles in molting, feeding and morphology (PubMed:15581870)


This is E3 ubiquitin-protein ligase TM129 protein, from Human, contains 362 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2, Exploited by viral US11 proteins to mediate HLA class I proteins degradation


This is Ubiquitin thioesterase zranb1-B protein, from Zebrafish, contains 716 amino acids, has 3 RanBP2-type Zinc finger.

Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity), Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity), Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity), Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity), Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity), Required in the stress fiber dynamics and cell migration (By similarity)


This is Diacylglycerol kinase alpha protein, from Bovine, contains 734 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids, Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes, Also plays an important role in the biosynthesis of complex lipids, Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group, Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol

Belongs to the eukaryotic diacylglycerol kinase family


This is Aprataxin and PNK-like factor protein, from Bovine, contains 485 amino acids, has 2 PBZ-type Zinc finger.

PBZ-type

PBZ-type

Histone chaperone involved in single-strand and double-strand DNA break repair, Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (By similarity), Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (By similarity), Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro, Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity), Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ), Also acts as a negative regulator of cell pluripotency by promoting histone exchange, Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity)


This is Zinc finger protein 382 protein, from Rat, contains 549 amino acids, has 10 C2H2-type Zinc finger.

Functions as a sequence-specific transcriptional repressor


This is Endoribonuclease ZC3H12A protein, from Rat, contains 596 amino acids, has 1 C3H1-type Zinc finger.

Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis, Functions as an endoribonuclease involved in mRNA decay, Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation, Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL), Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs, They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ, The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity), Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity), Self regulates by destabilizing its own mRNA, Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (By similarity), Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity), Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity), Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity), Affects the overall ubiquitination of cellular proteins, Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity), Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes, Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity), Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation, Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state, May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (By similarity), Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity), Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity)


This is Tripartite motif-containing protein 72 protein, from Rat, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites, Specifically binds phosphatidylserine, Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site, This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation, Probably acts upstream of the Ca(2+)-dependent membrane resealing process, Required for transport of DYSF to sites of cell injury during repair patch formation, Regulates membrane budding and exocytosis, May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity)


This is BRCA1-A complex subunit RAP80 protein, from Pig, contains 721 amino acids, has 1 UBZ4-type Zinc finger.

Ubiquitin-binding protein, Specifically recognizes and binds 'Lys-63'-linked ubiquitin, Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs), The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin, May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo, Does not bind Lys-48'-linked ubiquitin, May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1


This is Fez family zinc finger protein 1 protein, from Human, contains 475 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor, Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN), Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation, Expression is required in OSN to cell-autonomously regulate OSN axon projections, Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons, May be required for correct rostral migration of the interneuron progenitors (By similarity)


This is Protein FAM170A protein, from Human, contains 330 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes, Binds to heat shock promoter elements (HSE)


This is Protein disulfide isomerase pTAC5, chloroplastic protein, from Mouse-ear cress, contains 387 amino acids, has 1 CR-type Zinc finger.

CR-type

Exhibits zinc-dependent disulfide isomerase activity, Required for seedling and chloroplast development under heat stress, probably by maintaining plastid-encoded RNA polymerase (PEP)-dependent transcription

Plastid, chloroplast stroma, chloroplast nucleoid


This is E3 SUMO-protein ligase EGR2 protein, from Pig, contains 471 amino acids, has 3 C2H2-type Zinc finger.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity

Belongs to the EGR C2H2-type zinc-finger protein family


This is Atypical protein kinase C protein, from Fruit fly, contains 606 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation, During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte, Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity, Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex, Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells, Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization, Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins, Involved in symmetric adherens junction positioning during embryogenesis, Required for polarization of the spermatid cyst which is necessary for sperm differentiation, Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity, Plays a role in memory enhancement

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Probable ribonuclease ZC3H12D protein, from Human, contains 527 amino acids, has 1 C3H1-type Zinc finger.

May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561), May function as RNase and regulate the levels of target RNA species (Potential), In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560), Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687), Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561)


This is Lethal(3)malignant brain tumor-like protein 1 protein, from Mouse, contains 826 amino acids, has 1 CCHHC-type Zinc finger.

CCHHC-type

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications, PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription, Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes, Also recognizes and binds RB1/RB monomethylated at 'Lys-860', Participates in the ETV6-mediated repression, Probably plays a role in cell proliferation, Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity)


This is E3 ubiquitin-protein ligase RNF19B protein, from Mouse, contains 732 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1, Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells, Protects against staurosporin-induced cell death (By similarity)

Belongs to the RBR family, RNF19 subfamily


This is PR domain zinc finger protein 12 protein, from Mouse, contains 365 amino acids, has 3 C2H2-type Zinc finger.

Involved in the positive regulation of histone H3-K9 dimethylation

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Transcriptional repressor CTCFL protein, from Mouse, contains 636 amino acids, has 11 C2H2-type Zinc finger.

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers, Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR), Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2, This probably leads to recruit de novo DNA methyltransferases at these sites, Seems to act as tumor suppressor, In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter, Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters

Belongs to the CTCF zinc-finger protein family


This is Baculoviral IAP repeat-containing protein 7 protein, from Mouse, contains 285 amino acids, has 1 RING-type Zinc finger.

RING-type

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control, Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity, As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival, May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions, Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine, Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2, This activation depends on TAB1 and MAP3K7/TAK1, In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9


This is Ataxin-7-like protein 3 protein, from Mouse, contains 347 amino acids, has 1 SGF11-type Zinc finger.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination, Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B, The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription, Required for nuclear receptor-mediated transactivation, Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex, Regulates H2B monoubiquitination (H2Bub1) levels, Affects subcellular distribution of ENY2, USP22 and ATXN7L3B


This is TRMT1-like protein protein, from Mouse, contains 728 amino acids, has 1 C2H2-type Zinc finger.

May play a role in motor coordination and exploratory behavior

Belongs to the class I-like SAM-binding methyltransferase superfamily, Trm1 family


This is Myosin-binding protein H-like protein, from Human, contains 354 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Myosin-binding protein which plays a role in cardiac function (PubMed:28778945), Seems to regulate conduction in the atria and ventricular conduction systems (PubMed:28778945)

Belongs to the immunoglobulin superfamily, MyBP family


This is Retinoic acid receptor gamma-B protein, from Zebrafish, contains 489 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), Required for hindbrain development

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is CMRF35-like molecule 8 protein, from Rat, contains 310 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation, Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6


This is E3 ubiquitin-protein ligase BRE1A protein, from Bovine, contains 975 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively), It thereby plays a central role in histone code and gene regulation, The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory, Required for transcriptional activation of Hox genes, Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator, Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation


This is Zinc finger protein Aiolos protein, from Bovine, contains 509 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 4; atypical

C2H2-type 6; atypical

Transcription factor that plays an important role in the regulation of lymphocyte differentiation, Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state, Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase ARIH1 protein, from Bovine, contains 555 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3, Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets, The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2, E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes, Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear, According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest, According to another report EIF4E2 ubiquitination leads to its subsequent degradation, Acts as the ligase involved in ISGylation of EIF4E2, In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, may act in nuclear subcellular localization and nuclear morphology

Belongs to the RBR family, Ariadne subfamily


This is Cellulose synthase A catalytic subunit 4 [UDP-forming] protein, from Rice, contains 989 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation (By similarity), Involved in the secondary cell wall formation

Belongs to the glycosyltransferase 2 family, Plant cellulose synthase subfamily


This is Junctional adhesion molecule 3B protein, from Zebrafish, contains 302 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Junctional adhesion protein that mediates heterotypic cell-cell interactions to regulate different cellular processes (By similarity), During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes (PubMed:22180726)


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Rhesus macaque, contains 254 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG), Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC), Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (PubMed:33208458), Mediates IgG effector functions on natural killer (NK) cells, Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation, Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC, Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity), Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes, Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation, The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (By similarity), Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity), Mediates the antitumor activities of therapeutic antibodies, Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821)


This is Vitamin D3 receptor protein, from Pig, contains 427 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells, Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR, The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity), Plays a central role in calcium homeostasis (By similarity), Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)


This is mRNA decay activator protein ZFP36L2 protein, from Western clawed frog, contains 362 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (By similarity), Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity), Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity), Binds to 3'-UTR ARE of numerous mRNAs (By similarity), Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity), Required for tubulogenesis during pronephros development (By similarity)


This is Butyrophilin subfamily 2 member A2 protein, from Mouse, contains 514 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is E3 ubiquitin-protein ligase SH3RF1 protein, from Bovine, contains 840 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity, In the absence of an external substrate, it can catalyze self-ubiquitination, Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis, Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway, Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation, Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells, Plays a crucial role in the migration of neocortical neurons in the developing brain, Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly


This is E3 ubiquitin-protein ligase XIAP protein, from African clawed frog, contains 488 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins (By similarity), Acts as a direct caspase inhibitor (By similarity), E3 ubiquitin-protein ligase that acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of ripk2 downstream of NOD1 and NOD2, thereby transforming ripk2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity), A key apoptotic suppressor in eggs (PubMed:15853809), Acts as a positive regulator of Wnt signaling (PubMed:22304967)


This is E3 ubiquitin-protein ligase SH3RF1 protein, from Zebrafish, contains 867 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity, In the absence of an external substrate, it can catalyze self-ubiquitination, Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway


This is DNA-dependent metalloprotease SPRTN protein, from Bovine, contains 487 amino acids, has 1 UBZ4-type Zinc finger.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity, DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde, Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis, Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity), Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs, SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity), Involved in recruitment of VCP/p97 to sites of DNA damage, Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation, Does not activate CHEK1 in response to DNA damage, May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA, Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity)


This is Ubiquitin carboxyl-terminal hydrolase 20 protein, from Zebrafish, contains 911 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2), Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2, Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)

Belongs to the peptidase C19 family, USP20/USP33 subfamily


This is Insulinoma-associated protein 1 protein, from Bovine, contains 522 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 4 C2H2-type Zinc finger.

C2H2-type 1; atypical

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development, Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters, Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner, Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway, Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases, Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism, Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4', Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex, Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system, Promotes cell cycle signaling arrest and inhibition of cellular proliferation


This is Leukocyte immunoglobulin-like receptor subfamily A member 5 protein, from Human, contains 299 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May play a role in triggering innate immune responses, Does not seem to play a role for any class I MHC antigen recognition


This is E3 ubiquitin-protein ligase MARCHF11 protein, from Rat, contains 398 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, May play a role in ubuquitin-dependent protein sorting in developmenting spermatids


This is Ubiquitin carboxyl-terminal hydrolase 33 protein, from Bovine, contains 912 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling, Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate, Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling, Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2), Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2, Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2, This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins, Deubiquitinates DIO2, thereby regulating thyroid hormone regulation, Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)


This is Ubiquitin thioesterase ZRANB1 protein, from Bovine, contains 708 amino acids, has 3 RanBP2-type Zinc finger.

Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity), Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity), Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (By similarity), Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (By similarity), Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity), Required in the stress fiber dynamics and cell migration (By similarity)


This is Ribonuclease ZC3H12A protein, from Bovine, contains 583 amino acids, has 1 C3H1-type Zinc finger.

Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis, Functions as an endoribonuclease involved in mRNA decay, Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation, Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL), Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs, They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ, The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity), Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity), Self regulates by destabilizing its own mRNA, Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (By similarity), Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity), Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity), Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity), Affects the overall ubiquitination of cellular proteins, Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity), Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes, Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity), Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation, Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state, May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (By similarity), Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity), Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity)


This is E3 ubiquitin-protein ligase UHRF1 protein, from Bovine, contains 786 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification, Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication, In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins, Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication, Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications, Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML, It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo, Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation (By similarity)


This is RAF proto-oncogene serine/threonine-protein kinase protein, from Bovine, contains 648 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation, RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2), The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75', Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation, Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity, Phosphorylates TNNT2/cardiac muscle troponin T, Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1), Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death, Regulates Rho signaling and migration, and is required for normal wound healing, Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN, Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity)

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is TANK-binding kinase 1-binding protein 1 protein, from Human, contains 615 amino acids, has 1 UBZ1-type Zinc finger.

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity


This is Selection and upkeep of intraepithelial T-cells protein 1 protein, from Mouse, contains 364 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus, Plays a central role in mediating key epithelial-immune interactions by being involved in the selection of Vgamma5(+)Vdelta1(+) T-cells, which constitute 90% of epidermal gammadelta T-cells


This is Protein CHROMOSOME TRANSMISSION FIDELITY 7 protein, from Mouse-ear cress, contains 345 amino acids, has 1 CCHH-type Zinc finger.

CCHH-type

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:20671110), Involved in preservation of genome integrity and meiosis (PubMed:23750584, PubMed:20671110), Required for DNA repair and for the regulation of chromosome segregation during mitotic cell division (PubMed:23750584, PubMed:20671110), Knock-down mutants are extremely dwarf (PubMed:20671110), Regulator of sister chromatid cohesion in meiosis which negatively regulates cohesin association with chromatin, acting as an antagonist of WAPL1 and WAPL2 (PubMed:26813623)

Belongs to the acetyltransferase family, ECO subfamily


This is Progesterone receptor protein, from Western lowland gorilla, contains 933 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcriptional activator of several progesteron-dependent promoters in a variety of cell types, Involved in activation of SRC-dependent MAPK signaling on hormone stimulation

Belongs to the nuclear hormone receptor family


This is TNF receptor-associated factor 6 protein, from Pig, contains 541 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation, Leads to the activation of NF-kappa-B and JUN (By similarity), Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity), Represses c-Myb-mediated transactivation, in B-lymphocytes, Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity), Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation, Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity), Participates also in the TCR signaling by ubiquitinating LAT (By similarity)

Belongs to the TNF receptor-associated factor family, A subfamily


This is Sine oculis-binding protein homolog protein, from Human, contains 873 amino acids, has 2 FCS-type Zinc finger.

FCS-type

FCS-type

Implicated in development of the cochlea


This is Ubiquitin carboxyl-terminal hydrolase 20 protein, from Bovine, contains 912 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis, Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination, Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization, Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1, Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2), Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2, Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2, This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins, Deubiquitinates DIO2, thereby regulating thyroid hormone regulation, Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity, Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability, Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol


This is Ubiquitin carboxyl-terminal hydrolase 16 protein, from Zebrafish, contains 815 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator, Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis, Regulates Hox gene expression via histone H2A deubiquitination, Prefers nucleosomal substrates, Does not deubiquitinate histone H2B

Belongs to the peptidase C19 family, USP16 subfamily


This is CMRF35-like molecule 7 protein, from Human, contains 201 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2


This is Zinc finger protein 785 protein, from Human, contains 405 amino acids, has 7 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Protein kinase C beta type protein, from Western clawed frog, contains 670 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation, Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival, Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling, Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates isoform p66Shc of shc1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer, Acts as a coactivator of androgen receptor (andr)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is E3 ubiquitin-protein ligase NEURL1B protein, from Human, contains 555 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands


This is HEPACAM family member 2 protein, from Human, contains 462 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Required during prometaphase for centrosome maturation, Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation


This is Protein kinase C-like 3 protein, from Caenorhabditis briggsae, contains 597 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Required for the normal progression of embryogenesis and viability of the organism, Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3, Required for epithelial cell polarity in the distal spermatheca, Phosphorylates serine residues of num-1, Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury


This is Zinc finger protein ZPR1 protein, from Olive baboon, contains 459 amino acids, has 2 C4-type Zinc finger.

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus, Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies, Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons, Plays a role in the splicing of cellular pre-mRNAs, May be involved in H(2)O(2)-induced neuronal cell death (By similarity)


This is 30-kDa cleavage and polyadenylation specificity factor 30 protein, from Mouse-ear cress, contains 631 amino acids, has 3 C3H1-type Zinc finger.

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity), Mediates poly(A) site selection (PubMed:23136375), Binds RNA in a calcium-dependent manner (PubMed:16500995, PubMed:17576667, PubMed:20214900), Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a prelude to the polyadenylation (PubMed:17576667), Involved in the post-transcriptional control, probably via poly(A) addition, of the responses of plants to stress, especially genes mediating tolerance to oxidative stress (PubMed:18545667), Plays a role in the regulation of salicylic acid (SA) production via the control of messenger RNA 3' end processing, thus being a key component of programmed cell death and plant immune responses required for resistance to virulent Pseudomonas syringae pv tomato DC3000 (Pst) (PubMed:24706550)


This is NF-kappa-B essential modulator protein, from Pig, contains 419 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor, Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways, Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin, Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity, Essential for viral activation of IRF3, Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination


This is E3 ubiquitin-protein ligase rnf168 protein, from Western clawed frog, contains 535 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage, Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination, Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates, This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of tp53bp1 and brca1, Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 3 protein, from Rat, contains 626 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Promotes neurite outgrowth in hippocampal neurons (By similarity)


This is E3 ubiquitin-protein ligase makorin-2 protein, from African clawed frog, contains 409 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity), Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway (PubMed:18198183), Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression (PubMed:18198183)


This is Protein odd-skipped-related 1 protein, from Rat, contains 266 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development

Belongs to the Odd C2H2-type zinc-finger protein family


This is Ubiquitin carboxyl-terminal hydrolase 51 protein, from Mouse, contains 661 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinates histone H2A at 'Lys-13' and 'Lys-15' and regulates DNA damage response, USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1 foci


This is Protein EARLY HEADING DATE 2 protein, from Rice, contains 475 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription activator that acts as a flowering master switch in both long and short days, independently of the circadian clock (PubMed:18790997, PubMed:18725639, PubMed:18774969, PubMed:19304997, PubMed:24280027), Promotes flowering upstream of HD1 by up-regulating FTL1, FTL4, FTL5, FTL6, EHD1, HD3A and RFT1 (PubMed:18790997, PubMed:18725639, PubMed:18774969), Seems to repress FTL11 expression (PubMed:18725639), May recognize the consensus motif 5'-TTTGTCGTAAT-3' in target gene promoters (PubMed:18725639)


This is E3 ubiquitin-protein ligase TRIM11 protein, from Rat, contains 467 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX, Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis, May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences, May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity), Mediates MED15 ubiquitination leading to proteasomal degradation, May contribute to the innate restriction of retroviruses, Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression, Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain, May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle, Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2, Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity)


This is Synaptogenesis protein syg-1 protein, from Caenorhabditis elegans, contains 730 amino acids, has 5 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Cell adhesion protein (PubMed:15035988), Involved in synapse formation in the HSNL egg-laying motor neuron (PubMed:12628183, PubMed:15035988, PubMed:21858180, PubMed:24485456), Inhibits assembly of the SCF(sel-10) E3 ubiquitin ligase complex at synapses, and protects them from elimination (PubMed:17626846), Also required for F-actin assembly at the synaptic region and for axon branch formation (PubMed:24439377)

Belongs to the immunoglobulin superfamily


This is Rho guanine nucleotide exchange factor 2 protein, from Pig, contains 961 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Activates Rho-GTPases by promoting the exchange of GDP for GTP, May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer, Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, May stimulate instead the cortical activity of Rac, Inactive toward CDC42, TC10, or Ras-GTPases, Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens, Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase, Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2, Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability, Involved in neuronal progenitor cell division and differentiation, Involved in the migration of precerebellar neurons


This is OTU domain-containing protein 7B protein, from Mouse, contains 840 amino acids, has 1 A20-type Zinc finger.

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses, In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (PubMed:23334419), Negatively regulates mucosal immunity against infections (PubMed:23334419), Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241), Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (PubMed:26903241), Mediates deubiquitination of EGFR (By similarity), Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains, Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure, Hydrolyzes both linear and branched forms of polyubiquitin (By similarity)


This is Zinc finger and BTB domain-containing protein 42 protein, from Human, contains 422 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional repressor, Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes

Belongs to the krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily


This is E3 ubiquitin-protein ligase RNF168 protein, from Rat, contains 564 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage, Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination, Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates, This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1, Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites, Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region, Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)


This is E3 ubiquitin-protein ligase APD3 protein, from Mouse-ear cress, contains 404 amino acids, has 1 RING-type Zinc finger.

RING-type

Involved in pollen mitosis II (PMII) regulation during male gametogenesis


This is Nuclear receptor subfamily 1 group D member 1 protein, from Sheep, contains 614 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1, Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis, Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis, Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG, Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells, Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1, Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway, Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep, In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function, In addition to its activity as a repressor, can also act as a transcriptional activator, In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis, In collaboration with SP1, activates GJA1 transcription in a heme-independent manner (By similarity), Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity), Represses the transcription of CES2 (By similarity), Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity), Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity), Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity), Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity), Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity)


This is Interference hedgehog protein, from Fruit fly, contains 906 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc)

Belongs to the immunoglobulin superfamily, IHOG family


This is Interference hedgehog protein, from Fruit fly, contains 880 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is TNF receptor-associated factor 6 protein, from Rat, contains 530 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation, Leads to the activation of NF-kappa-B and JUN (By similarity), Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity), Represses c-Myb-mediated transactivation, in B-lymphocytes, Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity), Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation, Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity), Participates also in the TCR signaling by ubiquitinating LAT (By similarity)


This is Immunoglobulin-like domain-containing receptor 2 protein, from Mouse, contains 661 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion (PubMed:33863978, PubMed:23826244), With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (PubMed:23239027), Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694), In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060)

Belongs to the immunoglobulin superfamily, LISCH7 family


This is T-cell-interacting, activating receptor on myeloid cells protein 1 protein, from Human, contains 271 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May act as receptor (By similarity), Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901), Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity)


This is T-cell-interacting, activating receptor on myeloid cells protein 1 protein, from Mouse, contains 288 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May act as receptor, Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface, Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils


This is E3 ubiquitin-protein ligase UHRF1 protein, from African clawed frog, contains 772 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger.

PHD-type

RING-type

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification, Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication, In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins, Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication, Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications, Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins, However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo


This is TNF receptor-associated factor 6 protein, from Sooty mangabey, contains 522 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type


This is TNF receptor-associated factor 6 protein, from Rhesus macaque, contains 522 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type


This is Breast cancer type 1 susceptibility protein homolog protein, from Caenorhabditis elegans, contains 612 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair (PubMed:16628214), Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example (PubMed:14711411, PubMed:16628214, PubMed:24424777, PubMed:26903030, PubMed:30383754), Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells (PubMed:18219312, PubMed:19646877, PubMed:24424777, PubMed:26903030), In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand break repair to ensure sister chromatid recombination and aid chromosome stability (PubMed:14711411, PubMed:18219312, PubMed:24424777), Required for normal cell cycle progression (PubMed:20207739), Along with brap-2 modulates the expression of cell cycle arrest protein cki-1 in response to increased levels of reactive oxygen species (PubMed:20207739), Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity (PubMed:14711411), When bound to chromatin, the brc-1-brd-1 heterodimer within the CeBCD complex is inactive during normal conditions, but in response to DNA damage, the brc-1-brd-1 heterodimer associates with other proteins such as the recombinase rad-51 or the E2-ubiquitin-conjugating enzyme let-70, which activate the CeBCD complex as an E3-ubiquitin ligase (PubMed:16628214), Moreover, association between the brc-1-brd-1 heterodimer and rad-51 and let-70, probably requires DNA checkpoint proteins such as atl-1 and mre-11 in order to induce ubiquitination at DNA damage sites (PubMed:16628214), To this end, the brc-1-brd-1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:14711411)


This is Interleukin-1 receptor accessory protein-like 1-B protein, from Zebrafish, contains 700 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel, During presynaptic differentiation may regulate both synaptic vesicle accumulation in axon terminals and subsequent axon terminal remodeling

Belongs to the interleukin-1 receptor family


This is Transcription factor elt-3 protein, from Caenorhabditis elegans, contains 317 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcription factor (PubMed:18662544, PubMed:28600327), Required, in concert with signal transducer and transcription factor sta-2, for up-regulation of the vacuolar H(+)-ATPase and acceleration of lysosome maturation at molt (PubMed:31735670), Involved in regulating hypodermal development, perhaps acting downstream of transcription factor elt-1 (PubMed:11259601), Modulates environmentally induced changes in collagen gene expression, including rol-6, sqt-1, lon-3, and dpy-13 (PubMed:32229533), Involved in regulating expression of various genes, including gst-4, sod-3, ugt-9, and col-144 (PubMed:18662544, PubMed:28600327), In response to oxidative stress, required to up-regulate expression of gst-4 mRNA (PubMed:28600327), Regulated by the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:18662544), Plays a role in longevity (PubMed:18662544, PubMed:23262285), May regulate the expression of genes that control sensitivity to osmotic stress, in conjunction with the GATA region-binding transcription factor elt-2 (PubMed:20126308), May form a transcriptional circuit with GATA factors egl-18 and elt-6 (PubMed:18662544)


This is Wilms tumor protein homolog A protein, from African clawed frog, contains 414 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor required for development of the vascular component of the pronephric kidney, the glomus; may repress tubule-specific gene expression in the portion of the pronephros fated to form the glomus, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity), Inhibits Wnt-signaling during embryonic development, Function may be isoform-specific: the isoform containing the KTS motif is less effective in inhibiting wnt signaling

Belongs to the EGR C2H2-type zinc-finger protein family


This is Lysine-specific demethylase JMJ29 protein, from Mouse-ear cress, contains 883 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type; atypical Zinc finger.

RING-type; degenerate

B box-type; atypical

May function as histone H3 lysine demethylase and be involved in regulation of gene expression

Belongs to the JARID1 histone demethylase family


This is Major histocompatibility complex class I-related gene protein protein, from Bovine, contains 336 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells, In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity), Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis, Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity), May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin, Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity), During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity), Acts as an immune sensor of cancer cell metabolome, May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity)


This is Protein ZAR1-like protein, from Mouse, contains 291 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:31598710), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (PubMed:31598710)

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is Extra-large guanine nucleotide-binding protein 2 protein, from Mouse-ear cress, contains 861 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity), Binds GTP with specificity, Plays a role in the root morphogenesis by regulation of the cell proliferation, Acts as a positive regulator in resistance to pathogen that triggers the salicylic acid (SA) pathway, Promotes the DNA binding activity of RTV1 specifically to promoter regions of FT and SOC1 in vivo leading to the activation of floral integrator genes

Belongs to the G-alpha family, XLG subfamily


This is Zip homologous protein 3 protein, from Caenorhabditis elegans, contains 389 amino acids, has 1 RING-type Zinc finger.

RING-type

Recruited co-dependently with zhp-4 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination (PubMed:15340062, PubMed:18949042, PubMed:29521627, PubMed:30379819), In the early stages of pachytene, in complex with zhp-4, recruited by the zhp-1-zhp-2 heterodimer to designated crossover sites along the homolog pair to stabilize other pro-crossover factors such as rmh-1, msh-5 and cosa-1 (PubMed:29521627, PubMed:30379819), This in turn facilitates crossover and promotes the formation of chiasma in each meiotic nucleus at the late pachytene stage of meiosis (PubMed:29521627, PubMed:30379819), Plays a role in the segregation of homologous chromosomes following the completion of crossovers (PubMed:18949042), Together with him-14 and msh-5 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells (PubMed:23832114)


This is Histone acetyltransferase esa1 protein, from Aspergillus nidulans, contains 508 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


This is Nicotinate catabolism cluster-specific transcription factor protein, from Aspergillus nidulans, contains 865 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor that specifically regulates the expression of the hxn gene cluster that mediates the degradation of nicotinate and related metabolites (PubMed:4581274, PubMed:29212709)


This is Telomeric repeat-binding subunit 1 protein, from Tetrahymena thermophila (strain SB210), contains 701 amino acids, has 1 C4-type Zinc finger.

Single-stranded DNA (ssDNA)-binding protein that mediates the recruitment of telomerase to telomeric DNA (PubMed:19941821, PubMed:20363756, PubMed:25225329, PubMed:22143754), Telomerase is an essential ribonucleoprotein (RNP) enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:19941821), Acts as part of a replication protein A (RPA)-related subcomplex of the holoenzyme telomerase ribonucleoprotein complex: TEB1 specifically recognizes and binds telomeric ssDNA, thereby mediating the recruitment of the holoenzyme telomerase RNP complex to telomeres (PubMed:19941821, PubMed:25225329, PubMed:27895115), TEB1 is related to RPA1 subunit of the RPA complex but is specific to telomeric DNA, which is not the case of RPA1 (PubMed:25225329)

Belongs to the replication factor A protein 1 family