This is E3 ubiquitin-protein ligase CBL-B protein, from Mouse, contains 982 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome, Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways, In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production, Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation, In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy, In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation, Slightly promotes SRC ubiquitination, May be involved in EGFR ubiquitination and internalization, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3, In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719)


This is Protrudin protein, from Mouse, contains 415 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (By similarity), Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (PubMed:24251978), Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner, Contributes to both the formation and stabilization of the tubular ER network, Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (By similarity), Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons, Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701)


This is Histone-lysine N-trimethyltransferase SMYD5 protein, from Mouse, contains 416 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (PubMed:22921934, PubMed:28250819), In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (PubMed:22921934), Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (PubMed:28951459), Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (PubMed:28951459), Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28250819)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Zinc finger protein 746 protein, from Mouse, contains 652 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase RNF149 protein, from Mouse, contains 394 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase, Ubiquitinates BRAF, inducing its proteasomal degradation


This is CMRF35-like molecule 7 protein, from Mouse, contains 209 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP


This is E3 ubiquitin-protein ligase RNF180 protein, from Mouse, contains 592 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2


This is TRAF-type zinc finger domain-containing protein 1 protein, from Mouse, contains 580 amino acids, has 1 TRAF-type Zinc finger.

TRAF-type

Negative feedback regulator that controls excessive innate immune responses, Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways, May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation, May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3


This is High affinity nerve growth factor receptor protein, from Mouse, contains 799 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons, High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3, However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival, Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation, Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation, Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival, Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival, Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival, In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is E3 ubiquitin-protein ligase DTX3L protein, from Mouse, contains 748 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses, Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4, In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me), PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites, By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication, Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM, In addition, required for the recruitment of HGS and STAM to early endosomes


This is E3 ubiquitin-protein ligase RNF10 protein, from Mouse, contains 804 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling, Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome, Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation, The action of RNF10 in iRQC is counteracted by USP10 (By similarity), May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression, Acts as a regulator of Schwann cell differentiation and myelination (By similarity)


This is Polycomb group RING finger protein 5 protein, from Mouse, contains 256 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:27136092, PubMed:28596365), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity), Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365)


This is Tax1-binding protein 1 homolog protein, from Mouse, contains 814 amino acids, has 2 UBZ1-type Zinc finger.

Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:18239685, PubMed:33207181), Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates, Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (By similarity), Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:18239685), Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (By similarity), As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis, Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (By similarity)


This is Zinc finger CCCH-type antiviral protein 1 protein, from Mouse, contains 946 amino acids, has 4 C3H1-type Zinc finger.

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs, Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end, It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end, Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV), Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation, Isoform 1 is a more potent viral inhibitor than isoform 2, Isoform 2 acts as a positive regulator of RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs)


This is Zinc finger and SCAN domain-containing protein 10 protein, from Mouse, contains 782 amino acids, has 14 C2H2-type Zinc finger.

Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency, Can both activate and /or repress expression of target genes, depending on the context, Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence, Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4


This is Nuclear receptor subfamily 1 group D member 1 protein, from Mouse, contains 615 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1, Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis, Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis, Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG, Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells, Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1, Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway, Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep, In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function, In addition to its activity as a repressor, can also act as a transcriptional activator, In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis, In collaboration with SP1, activates GJA1 transcription in a heme-independent manner, Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (PubMed:30555544), Represses the transcription of CES2 (PubMed:29653076), Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (PubMed:24794873), Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (PubMed:27686098), Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (PubMed:29533925), Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (PubMed:30792350), Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (PubMed:30096135)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Kinase suppressor of Ras 2 protein, from Mouse, contains 951 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Location-regulated scaffold connecting MEK to RAF, Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro), Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1, Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro), Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling, Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family


This is Lysine-specific demethylase 7A protein, from Mouse, contains 940 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone demethylase required for brain development, Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code, Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2, Demethylates H3K9me2 in absence of H3K4me3, Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate

Belongs to the JHDM1 histone demethylase family, JHDM1D subfamily


This is Putative histone-lysine N-methyltransferase PRDM6 protein, from Mouse, contains 596 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 2 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 4; degenerate

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression (PubMed:16537907, PubMed:17662997), Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells (PubMed:27181681, PubMed:16537907, PubMed:17662997), Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation, It is unclear whether it has histone methyltransferase activity in vivo, According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a (PubMed:16537907), According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro, 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (PubMed:17662997)


This is TNF receptor-associated factor 6 protein, from Bovine, contains 542 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation, Leads to the activation of NF-kappa-B and JUN (By similarity), Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity), Represses c-Myb-mediated transactivation, in B-lymphocytes, Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity), Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation, Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity), Participates also in the TCR signaling by ubiquitinating LAT (By similarity)

Belongs to the TNF receptor-associated factor family, A subfamily


This is Tripartite motif-containing protein 5 protein, from Lar gibbon, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2


This is Cold shock protein 2 protein, from Mouse-ear cress, contains 203 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Chaperone that binds to RNA, single- (ssDNA) and double-stranded (dsDNA) DNA, and unwinds nucleic acid duplex, Accelerates seed germination and seedling growth under cold stress, and contributes to enhancement of cold and freezing tolerance, Regulates flowering transition, and flower and seed development, Promotes seed germination under salt stress, May regulate respiratory oxygen uptake

Belongs to the cold shock protein (CSP) family


This is Eukaryotic translation initiation factor 2 subunit beta protein, from Mouse-ear cress, contains 268 amino acids, has 1 C4-type Zinc finger.

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex, Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex, In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)


This is Zinc finger protein ZAT12 protein, from Mouse-ear cress, contains 162 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional repressor involved in light acclimation, cold and oxidative stress responses, May regulate a collection of transcripts involved in response to high-light, cold and oxidative stress


This is Protein lin-28 homolog B protein, from Mouse, contains 247 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c, Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA, Does not act on pri-miR21, The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation, When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation, This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent, Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop (By similarity), Mediates MYC-induced let-7 repression (PubMed:19211792), When overexpressed, may stimulate growth of carcinoma cell lines (By similarity)


This is Leucine-rich repeat-containing protein 4 protein, from Rat, contains 652 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Synaptic adhesion protein, Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins, Organize the lamina/pathway-specific differentiation of dendrites, Plays an important role for auditory synaptic responses, Involved in the suppression of glioma


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 2 protein, from Rat, contains 788 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Promotes neurite outgrowth in hippocampal neurons, Enhances the cell surface expression of GRIN1 and GRIN2A NMDA receptor subunits, May play a role in redistributing DLG4 to the cell periphery (By similarity)


This is T-cell immunoreceptor with Ig and ITIM domains protein, from Human, contains 244 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells


This is Probable E3 SUMO-protein ligase RNF212 protein, from Human, contains 297 amino acids, has 1 RING-type Zinc finger.

RING-type

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes, Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11, May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites, Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity)


This is CMRF35-like molecule 2 protein, from Human, contains 205 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Forkhead box protein P1 protein, from Rat, contains 711 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional repressor, Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential, Plays an important role in the specification and differentiation of lung epithelium, Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2, Essential transcriptional regulator of B-cell development, Involved in regulation of cardiac muscle cell proliferation, Involved in the columnar organization of spinal motor neurons, Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections, The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins, Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3, Negatively regulates the differentiation of T follicular helper cells T(FH)s, Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18, Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis, Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor, Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B, Can negatively regulate androgen receptor signaling (By similarity), Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity)


This is Fibroblast growth factor receptor 4 protein, from Rat, contains 800 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis, Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19, Phosphorylates PLCG1 and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Zygotic DNA replication licensing factor mcm6-A protein, from African clawed frog, contains 823 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development, May replace mmcm6 in the mcm2-7 complex


This is E3 ubiquitin-protein ligase SH3RF2 protein, from Rat, contains 735 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E3 ubiquitin-protein ligase activity, Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169), Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation, Inhibits PPP1CA phosphatase activity (By similarity)


This is Cilium assembly protein DZIP1L protein, from Mouse, contains 774 amino acids, has 1 C2H2-type Zinc finger.

Involved in primary cilium formation (PubMed:28530676), Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (By similarity)

Cytoplasm, cytoskeleton, cilium basal body

Belongs to the DZIP C2H2-type zinc-finger protein family


This is F-box only protein 43 protein, from Human, contains 708 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization, Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase, Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750), Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis


This is Histone acetyltransferase ESA1 protein, from Wheat head blight fungus, contains 502 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


This is Arf-GAP domain and FG repeat-containing protein 1 protein, from Rat, contains 561 amino acids, has 1 C4-type Zinc finger.

Required for vesicle docking or fusion during acrosome biogenesis, May play a role in RNA trafficking or localization (By similarity)


This is E3 ubiquitin-protein ligase RNF8 protein, from Rat, contains 487 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites, Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF), Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites, Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases, For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains, Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5, Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (By similarity), Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta, In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (By similarity), In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation, Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase, Required in the testis, where it plays a role in the replacement of histones during spermatogenesis, At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis, Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis, May play a role in the regulation of RXRA-mediated transcriptional activity, Not involved in RXRA ubiquitination by UBE2E2 (By similarity)


This is E3 ubiquitin-protein ligase RING2 protein, from Rat, contains 308 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation, H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, May be involved in the initiation of both imprinted and random X inactivation, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility, E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4, Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity, Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers, Association with the chromosomal DNA is cell-cycle dependent, In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes, Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation


This is Histone acetyltransferase ESA1 protein, from Corn smut fungus, contains 565 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type


This is E3 SUMO-protein ligase nse2 protein, from Fission yeast, contains 250 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins, Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks, Plays a critical role in meiosis


This is Transcription initiation factor IIB protein, from Crab-eating macaque, contains 316 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II), Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA, Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex, Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle, Associates with chromatin to core promoter-specific regions, Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element, Modulates transcription start site selection, Exhibits also autoacetyltransferase activity that contributes to the activated transcription


This is Protein kinase C gamma type protein, from Crab-eating macaque, contains 697 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress, Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression, In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning, May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity, May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain, May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors, May also contributes to chronic morphine-induced changes in nociceptive processing, Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation, Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors, During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury, Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum, Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress, Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage, Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding, Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Ubiquitin carboxyl-terminal hydrolase 16 protein, from Crab-eating macaque, contains 826 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator, Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis, In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes, Regulates Hox gene expression via histone H2A deubiquitination, Prefers nucleosomal substrates, Does not deubiquitinate histone H2B, Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit

Belongs to the peptidase C19 family, USP16 subfamily


This is Mitochondrial ubiquitin ligase activator of NFKB 1 protein, from Crab-eating macaque, contains 352 amino acids, has 1 RING-type Zinc finger.

RING-type

Exhibits weak E3 ubiquitin-protein ligase activity, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation, Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion, Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations, Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization, Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway, May also be involved in the sumoylation of the membrane fission protein DNM1L, Inhibits cell growth, When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis, Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (By similarity), Can mediate RIGI sumoylation and disrupt its polyubiquitination (By similarity)


This is E3 ubiquitin-protein ligase Hakai protein, from Crab-eating macaque, contains 490 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1, Targets CDH1 for endocytosis and degradation, Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing, Its function in the WMM complex is unknown


This is Tumor necrosis factor alpha-induced protein 3 protein, from Crab-eating macaque, contains 790 amino acids, has 7 A20-type Zinc finger.

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity, Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways, In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3, In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3, Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains, This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B, Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin, Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation, Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation, Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2, Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation, Targets TRAF2 for lysosomal degradation, In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains, Inhibitor of programmed cell death, Has a role in the function of the lymphoid system, Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages (By similarity)


This is RNA-binding protein 4 protein, from Crab-eating macaque, contains 364 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation, Modulates alternative 5'-splice site and exon selection, Acts as a muscle cell differentiation-promoting factor, Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation, Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin, Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs, Required for the translational activation of PER1 mRNA in response to circadian clock, Binds directly to the 3'-UTR of the PER1 mRNA, Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation, Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress, Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions, Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs, Associates with miRNAs during muscle cell differentiation, Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity)


This is E3 ubiquitin-protein ligase RHF1A protein, from Mouse-ear cress, contains 371 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in the positive regulation of the gametogenesis progression, Mediates the proteasomal degradation of KRP6, a cyclin-dependent kinase inhibitor which accumulates during meiosis and blocks the progression of subsequent mitoses during gametophyte development, Functions in association with RHF2A (PubMed:18552199), Possesses E3 ubiquitin-protein ligase activity when associated with the E2 enzyme UBC8 in vitro (PubMed:15644464)


This is Peroxisome proliferator-activated receptor gamma protein, from Dog, contains 505 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase, It therefore controls the peroxisomal beta-oxidation pathway of fatty acids, Key regulator of adipocyte differentiation and glucose homeostasis, ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer, Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses, Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels


This is E3 SUMO-protein ligase NSE2 protein, from Rat, contains 247 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination, Is not be required for the stability of the complex, The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks, Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2, Required for recruitment of telomeres to PML nuclear bodies, Required for sister chromatid cohesion during prometaphase and mitotic progression


This is GDNF-inducible zinc finger protein 1 protein, from Mouse, contains 706 amino acids, has 10 C2H2-type Zinc finger.

Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'), May be regulating VSX2/HOX10 expression


This is Putative protein MSS51 homolog, mitochondrial protein, from Human, contains 460 amino acids, has 1 MYND-type Zinc finger.

MYND-type


This is E3 ubiquitin-protein transferase MAEA protein, from Mouse, contains 396 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, MAEA is required for normal cell proliferation, The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity), Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (PubMed:16707498), Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity), Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis (PubMed:16707498, PubMed:17071116), Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (PubMed:16707498), May contribute to nuclear architecture and cells division events (By similarity)


This is FLYWCH-type zinc finger-containing protein 1 protein, from Human, contains 716 amino acids, has 5 FLYWCH-type Zinc finger.

FLYWCH-type

FLYWCH-type

FLYWCH-type

FLYWCH-type

FLYWCH-type

Transcription cofactor (PubMed:30097457), Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457), May play a role in DNA-damage response signaling (PubMed:33924684), Binds specifically to DNA sequences at peri-centromeric chromatin loci


This is DNA (cytosine-5)-methyltransferase 3A protein, from Chicken, contains 877 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Required for genome-wide de novo methylation and is essential for development, DNA methylation is coordinated with methylation of histones, It modifies DNA in a non-processive manner and also methylates non-CpG sites, Acts as a transcriptional corepressor for ZNF238, Can actively repress transcription through the recruitment of HDAC activity, Also has weak auto-methylation activity on some Cys residue in absence of DNA

Belongs to the class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family


This is Histone acetyltransferase esa1 protein, from Neosartorya fumigata, contains 483 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


This is C2H2 finger domain transcription factor crzA protein, from Neosartorya fumigata, contains 754 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Transcription factor involved in the regulation of calcium ion homeostasis (PubMed:18298443), Regulates genes encoding calcium transporters, transcription factors and genes that could be directly or indirectly involved in calcium metabolism (PubMed:20078882), Supports especially pmcA, pmcB and pmcC expression encoding for calcium-translocating P-type ATPases (PubMed:18298443, PubMed:22649543), Binds target promoters at motif A[GT][CG]CA[AC][AG] (PubMed:25196896), Plays an essential role germination, radial growth, and asexual development (PubMed:18456861, PubMed:18298443), Also plays a major role in proper chitin and glucan incorporation into the cell wall (PubMed:19015336), Involved in the high-osmolarity glycerol response (HOG) signaling pathway (PubMed:25196896), Required for pathogenicity in an experimental murine model of invasive pulmonary aspergillosis (PubMed:18456861, PubMed:18298443, PubMed:22649543, PubMed:25196896)


This is C2H2 finger domain transcription factor sebA protein, from Neosartorya fumigata, contains 618 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor that is involved in the response to heat shock, oxidative stress, and poor nutrient conditions (PubMed:22345349), Controls expression of oxidative stress response genes such as ccp1, cat1, cat2, sod2; as well as of heat shock genes such as hsf1, hsp30 and hsp90 (PubMed:22345349), Negatively controls the expression of the fumiquinazoline (fmq) cluster via binding to the STRE motifs at the fmqA-D promoters (PubMed:33705521), Plays a role in virulence (PubMed:22345349, PubMed:33705521)


This is Next to BRCA1 gene 1 protein protein, from Rat, contains 983 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis, Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates, Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity), In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity), In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity), Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity)


This is Zinc finger CW-type PWWP domain protein 2 protein, from Human, contains 356 amino acids, has 1 CW-type Zinc finger.

CW-type

Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034), The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034)


This is Nuclear receptor subfamily 2 group C member 1 protein, from Mouse, contains 590 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism, Primarily repressor of a broad range of genes including ESR1 and RARB, Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity), Also activator of OCT4 gene expression, Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation, Mediator of retinoic acid-regulated preadipocyte proliferation

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Estrogen receptor protein, from Cat, contains 595 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP, Can activate the transcriptional activity of TFF1, Also mediates membrane-initiated estrogen signaling involving various kinase cascades,Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity)

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Non-structural maintenance of chromosomes element 1 protein, from Fission yeast, contains 232 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks, Plays a critical role in meiosis


This is Zinc finger C2HC domain-containing protein 1C protein, from Human, contains 456 amino acids, has 1 C2HC-type Zinc finger.


This is U4/U6.U5 tri-snRNP-associated protein 2 protein, from Human, contains 565 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367), Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint, Does not have ubiquitin-specific peptidase activity (PubMed:18728397)


This is SWI/SNF complex subunit SWI3C homolog protein, from Rice, contains 784 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Component of a multiprotein complex equivalent of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors (By similarity), May be involved in positive response to drought stress and modulation of root growth through its interaction with NMCP1 (PubMed:32129897)


This is TATA box-binding protein-associated factor RNA polymerase I subunit B protein, from Human, contains 588 amino acids, has 1 RRN7-type Zinc finger.

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription, Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3


This is NAD-dependent deacetylase sir2A protein, from Social amoeba, contains 512 amino acids, has 1 UBP-type Zinc finger.

UBP-type

NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression


This is E3 ubiquitin-protein ligase cblA protein, from Social amoeba, contains 665 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome, Up-regulates STATc tyrosine phosphorylation via an inhibitory effect on ptpC accumulation, Recognizes activated receptor tyrosine kinases, RTKs and terminates signaling


This is CMRF35-like molecule 1 protein, from Rat, contains 332 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Acts as an inhibitory receptor for myeloid cells and mast cells, Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells, Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis, Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands, May act as a coreceptor for interleukin 4 (IL-4), Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling, Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2, Inhibits osteoclast formation, Induces macrophage cell death upon engagement


This is E3 ubiquitin-protein ligase RNF185 protein, from Rat, contains 192 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1, Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation, Protects cells from ER stress-induced apoptosis, Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway, Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity, Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2


This is Zinc finger protein 385B protein, from Human, contains 471 amino acids, has 4 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

Matrin-type

May play a role in p53/TP53-mediated apoptosis


This is Sodium channel subunit beta-2 protein, from Mouse, contains 215 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel, The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli, Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)

Belongs to the sodium channel auxiliary subunit SCN2B (TC 8,A,17) family


This is N-acetyltransferase ESCO2 protein, from Human, contains 601 amino acids, has 1 CCHH-type Zinc finger.

CCHH-type

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495), Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together, In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase, Acetylates the cohesin component SMC3 (PubMed:21111234)

Belongs to the acetyltransferase family, ECO subfamily


This is RNA-binding protein ZC3H11 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 364 amino acids, has 1 C3H1-type Zinc finger.

RNA-binding protein involved in regulation of mRNA stability (PubMed:23592996), Binds AU-rich regions in the 3'-UTR of mRNAs and promotes their stabilization by recruiting a MKT1-containing complex (PubMed:23592996, PubMed:24470144), Stabilizes chaperone mRNAs during stress that causes an accumulation of misfolded or unfolded proteins in the cytoplasm (PubMed:23592996, PubMed:24470144, PubMed:27002830)


This is RNA-binding protein ZC3H20 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 405 amino acids, has 2 C3H1-type Zinc finger.

RNA-binding protein involved in regulation of mRNA stability (PubMed:31743541), Promotes mRNA stabilization by recruiting MKT1 and PBP1 (By similarity), Stabilizes mRNA required for differentiation from the bloodstream form to the procyclic form, and maintenance of the procyclic form (PubMed:31743541), Stabilizes transcripts encoding membrane and mitochondrial proteins, including AQP1 and GPEET2 procyclin (PubMed:31743541)


This is REH2-associated factor 1 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 524 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 5 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

C2H2-type 3; atypical

Plays an important role in mitochondrial mRNA editing by promoting the assembly of the mRNA editosome (PubMed:26769962, PubMed:31034523), Facilitates the recruitment of mRNA to the REH2C complex and promotes the interaction between various editing complexes including REH2C, GRBC, REMC and RECC complexes (PubMed:26769962, PubMed:31034523)


This is Tripartite motif-containing protein 5 protein, from Crab-eating macaque, contains 495 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Restricts infection by human immunodeficiency virus type 1 (HIV-1) (PubMed:22291694), Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (By similarity)


This is Tripartite motif-containing protein 5 protein, from Green monkey, contains 515 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2


This is PAN2-PAN3 deadenylation complex subunit PAN3 protein, from Human, contains 887 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP), PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins

Belongs to the protein kinase superfamily, PAN3 family


This is Biofilm regulator 1 protein, from Yeast, contains 422 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcription factor required for hyphal growth, biofilm formation, and virulence, Promotes formation of both conventional and pheromone-stimulated biofilms, Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner, Involved in the switch between two heritable states, the white and opaque states, These two cell types differ in many characteristics, including cell structure, mating competence, and virulence, Each state is heritable for many generations, and switching between states occurs stochastically at low frequency


This is Cell wall transcription factor ACE2 protein, from Yeast, contains 783 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis, Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1, Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection


This is Transcriptional regulator CRZ2 protein, from Yeast, contains 517 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Transcription factor that regulates pH-induced filamentation with RIM101, Required for yeast cell adherence to silicone substrate and biofilm formation


This is Biofilm and cell wall regulator 1 protein, from Yeast, contains 740 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor which acts as a master regulator of biofilm formation (PubMed:15964282, PubMed:17030992, PubMed:16839200, PubMed:20223293, PubMed:19959578, PubMed:20705667, PubMed:21829325, PubMed:21283544, PubMed:21407800, PubMed:22145027, PubMed:22265407, PubMed:22882910, PubMed:22589718), Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis (PubMed:20705667, PubMed:21283544, PubMed:21407800, PubMed:22544909, PubMed:22265407), Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 and HYR1 (PubMed:16839200, PubMed:17277173, PubMed:19197361, PubMed:20415594, PubMed:22145027, PubMed:22544909, PubMed:22589718), Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation (PubMed:20223293, PubMed:21407800, PubMed:22359502)


This is Transcriptional adapter 2 protein, from Yeast, contains 445 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA, SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes, At the promoters, SAGA is required for recruitment of the basal transcription machinery, SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation, ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B, Required for expression of many CAS5-dependent genes, Plays a key role in cell wall integrity, cell adhesion, hyphal development and pathogenesis


This is Transcriptional regulator NRG1 protein, from Yeast, contains 310 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters, Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response, Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion, Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway, Functions with UME6 in a negative feedback loop to control the level and duration of filament-specific gene expression in response to inducing conditions, Plays a key role in biofilm formation and dispersion, Also plays the role of a negative regulator of virulence in mice models, Required for the expression of the cell wall genes RBR1


This is Transcriptional regulator CRZ1 protein, from Yeast, contains 731 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity, Binds to the calcineurin-dependent response element, Plays a role in azole tolerance


This is E3 ubiquitin-protein ligase BRE1 protein, from Yeast, contains 681 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation


This is Transcriptional regulatory protein ASH1 protein, from Yeast, contains 449 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Component of the RPD3C(L) histone deacetylase complex (HDAC), Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity), Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis


This is Histone acetyltransferase ESA1 protein, from Yeast, contains 541 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


This is Chromatin modification-related protein YNG2 protein, from Yeast, contains 298 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair, Involved in cell cycle progression and meiosis (By similarity)


This is Transcriptional regulator STP2 protein, from Yeast, contains 584 amino acids, has 1 C2H2-type Zinc finger.

Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels, Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyphal form


This is Cell wall integrity transcriptional regulator CAS5 protein, from Yeast, contains 821 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor involved in the cell wall damage response, Acts with ADA2 to promote cell wall integrity, Required for expression of numerous cell wall biosynthesis inhibitor caspofungin-responsive genes, Plays a key role in adherence, hyphal development, and virulence


This is Suppressor of ferric uptake 1 protein, from Yeast, contains 517 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional regulator of iron-responsive genes, Represses expression of SEF1 and genes for iron uptake if iron is present, Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized, Promotes gastrointestinal commensalism in mice


This is Oxysterols receptor LXR-beta protein, from Bovine, contains 455 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity), Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4), Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8, Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity), Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity), Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles, Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity), Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity)


This is N-lysine methyltransferase SMYD2-A protein, from Zebrafish, contains 435 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Retinoic acid receptor RXR-gamma protein, from Rat, contains 463 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)


This is Lymphocyte activation gene 3 protein protein, from Rat, contains 525 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response


This is Ubiquitin carboxyl-terminal hydrolase 13 protein, from Mouse, contains 858 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD), Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes, Also deubiquitinates USP10, an essential regulator of p53/TP53 stability, In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13, Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD), Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex, Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination, Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains, In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly, Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data


This is DBIRD complex subunit ZNF326 protein, from Human, contains 582 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions, May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro


This is Tripartite motif-containing protein 5 protein, from Bolivian squirrel monkey, contains 494 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2


This is Tripartite motif-containing protein 5 protein, from Western lowland gorilla, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Tripartite motif-containing protein 5 protein, from Sumatran orangutan, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Tripartite motif-containing protein 5 protein, from Red-chested mustached tamarin, contains 494 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Tripartite motif-containing protein 5 protein, from Tantalus monkey, contains 515 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Restricts infection by human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV-mac) and N-tropic murine leukemia viruse (N-MLV) (PubMed:22291694), Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (By similarity)


This is Tripartite motif-containing protein 5 protein, from Vervet monkey, contains 515 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Restricts infection by human immunodeficiency virus type 1 (HIV-1) and N-tropic murine leukemia virus (N-MLV) (PubMed:22291694), Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (By similarity)


This is B3 domain-containing transcription repressor VAL2 protein, from Mouse-ear cress, contains 780 amino acids, has 1 CW-type Zinc finger.

CW-type

Transcriptional repressor of gene expression involved in embryonic pathways, such as LEC1, ABI3, and FUS3, Repressor of the sugar-inducible genes involved in the seed maturation program in seedlings, Plays an essential role in regulating the transition from seed maturation to seedling growth, Functionally redundant with VAL1/HSI2