This is Tyrosine-protein kinase transmembrane receptor ROR2 protein, from Mouse, contains 944 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes, It seems to be required for cartilage and growth plate development (PubMed:10700181), Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation, In contrast, has also been shown to have very little tyrosine kinase activity in vitro, May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, ROR subfamily


This is Inactive tyrosine-protein kinase transmembrane receptor ROR1 protein, from Mouse, contains 937 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity), Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (By similarity), In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350)


This is Semaphorin-4F protein, from Rat, contains 776 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity), Might also regulate differentiation of oligodendroglial precursor cells (PubMed:21945643), Has growth cone collapse activity against retinal ganglion-cell axons (PubMed:10051670)


This is PHD finger protein 1 protein, from Mouse, contains 559 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, Involved in DNA damage response and is recruited at double-strand breaks (DSBs), Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex, According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877), According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2, Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53


This is E3 ubiquitin-protein ligase ARIH1 protein, from Mouse, contains 555 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3, Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets, The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2, E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes, Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear, According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest, According to another report EIF4E2 ubiquitination leads to its subsequent degradation, Acts as the ligase involved in ISGylation of EIF4E2, In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, may act in nuclear subcellular localization and nuclear morphology

Belongs to the RBR family, Ariadne subfamily


This is E3 ubiquitin-protein ligase ARIH2 protein, from Mouse, contains 492 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (By similarity), Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity), The initial ubiquitin is then elongated (By similarity), E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex, Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination, May play a role in myelopoiesis (By similarity)


This is RAS guanyl-releasing protein 1 protein, from Mouse, contains 795 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP, Activates the Erk/MAP kinase cascade, Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras, Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity), Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (PubMed:17190838), May also function in differentiation of other cell types, Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (PubMed:15829980, PubMed:17210708)


This is Deformed epidermal autoregulatory factor 1 homolog protein, from Mouse, contains 566 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene, Down-regulates transcription of these genes, Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3', Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity), Regulates epithelial cell proliferation and side-branching in the mammary gland, Required for neural tube closure and skeletal patterning, Controls the expression of peripheral tissue antigens in pancreatic lymph nodes, Isoform 1 displays greater transcriptional activity than isoform 2, Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm, Transcriptional activator of EIF4G3 (By similarity), May also involved in behavior (PubMed:24726472)


This is Zinc finger protein AEBP2 protein, from Mouse, contains 504 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene, Plays a role in nucleosome localization of the PRC2 complex

Belongs to the AEBP2/jing C2H2-type zinc-finger family


This is ARF GTPase-activating protein GIT1 protein, from Rat, contains 770 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1 (PubMed:9826657), Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (PubMed:9826657), Through PAK1 activation, positively regulates microtubule nucleation during interphase, Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (By similarity), May promote cell motility both by regulating focal complex dynamics and by the activation of RAC1 (PubMed:10938112), May act as scaffold for MAPK1/3 signal transduction, recruiting MAPK1/3 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189), Plays a role in brain development and function, Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity), Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193, PubMed:17310244, PubMed:24297929, PubMed:25009255), In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane, These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12473661), May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (PubMed:12473661), In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (PubMed:12629171), In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783), May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity), Required for successful bone regeneration during fracture healing, The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity), May also play a role in angiogenesis during fracture healing (By similarity), In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (By similarity), Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (By similarity)


This is Interleukin-18 receptor accessory protein protein, from Mouse, contains 614 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:11046021, PubMed:15843532, PubMed:9792649), May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity)

Belongs to the interleukin-1 receptor family


This is Methyl-CpG-binding domain protein 1 protein, from Mouse, contains 636 amino acids, has 3 CXXC-type Zinc finger.

CXXC-type

CXXC-type

CXXC-type

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides, Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS), Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1, Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation, Isoform 1 can also repress transcription from unmethylated promoters


This is Nexilin protein, from Rat, contains 656 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Involved in regulating cell migration through association with the actin cytoskeleton, Has an essential role in the maintenance of Z line and sarcomere integrity


This is Poly [ADP-ribose] polymerase 1 protein, from Mouse-ear cress, contains 983 amino acids, has 2 PARP-type Zinc finger.

PARP-type

PARP-type

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity)


This is Dof zinc finger protein DOF2.5 protein, from Mouse-ear cress, contains 369 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor specifically involved in the maternal control of seed germination, Regulates transcription by binding to a 5'-AA[AG]G-3' consensus core sequence, May ensure the activation of a component that would trigger germination as a consequence of red light perception


This is Cytoplasmic 60S subunit biogenesis factor REI1 homolog 2 protein, from Mouse-ear cress, contains 395 amino acids, has 4 C2H2-type Zinc finger.

Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit, Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity), Can complement the growth defect of a yeast mutant lacking REI1 (PubMed:24038679), Required for leaf growth under cold temperature conditions (PubMed:24038679)


This is E3 ubiquitin-protein ligase MBR1 protein, from Mouse-ear cress, contains 704 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that functions as regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way, Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering

Belongs to the RING-type zinc finger family


This is E3 ubiquitin-protein ligase RHF2A protein, from Mouse-ear cress, contains 375 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in the positive regulation of the gametogenesis progression, Required for the degradation of KRP6, a cyclin-dependent kinase inhibitor which accumulates during meiosis and blocks the progression of subsequent mitoses during gametophytes development, Functions in association with RHF1A


This is E3 ubiquitin-protein ligase RHA2A protein, from Mouse-ear cress, contains 155 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid (ABA) signaling and responses to salt and osmotic stresses during seed germination and early seedling development (PubMed:19286935, PubMed:21478367), Acts additively with RHA2B in regulating ABA signaling and drought response (PubMed:21478367), Possesses E3 ubiquitin ligase activity in vitro (PubMed:15644464, PubMed:19286935)


This is E3 ubiquitin-protein ligase RHA2B protein, from Mouse-ear cress, contains 147 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid (ABA) signaling and responses to salt and osmotic stresses during seed germination and early seedling development, Acts additively with RHA2A in regulating ABA signaling and drought response, Possesses E3 ubiquitin ligase activity in vitro


This is Protein indeterminate-domain 5, chloroplastic protein, from Mouse-ear cress, contains 602 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor acting as a positive regulator of the starch synthase SS4, Controls chloroplast development and starch granule formation (PubMed:22898356), Binds DNA via its zinc fingers (PubMed:24821766), Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766)


This is Protein FAR1-RELATED SEQUENCE 3 protein, from Mouse-ear cress, contains 851 amino acids, has 1 SWIM-type Zinc finger.

SWIM-type

Putative transcription activator involved in regulating light control of development


This is Serrate RNA effector molecule protein, from Mouse-ear cress, contains 720 amino acids, has 1 C2H2-type Zinc finger.

Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery, Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs, Does not participate in sense post-transcriptional gene silencing, Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression, Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing, Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA), Required for pre-mRNA splicing


This is Transcription elongation factor TFIIS protein, from Mouse-ear cress, contains 378 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites (Probable), Involved in the control of seed dormancy and germination (PubMed:19150360, PubMed:21799800)


This is Zinc finger protein MAGPIE protein, from Mouse-ear cress, contains 506 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:17785527, PubMed:25829440), Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:17785527, PubMed:25829440), Interacts with the SCR and MGP promoters (PubMed:21935722), Does not show transcription activity by itself, but regulates the transcription of downstream genes through interaction with other transcription factors (PubMed:21935722), Binds DNA via its zinc fingers (PubMed:24821766), Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766), Positively involved in gibberellic acid (GA) signaling (PubMed:24821766)


This is V-set and transmembrane domain-containing protein 4 protein, from Mouse, contains 319 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors


This is Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 protein, from Mouse, contains 681 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (PubMed:25997951, PubMed:26427409, PubMed:28334377), Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:26427409, PubMed:28334377), Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (PubMed:25997951), Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (PubMed:28334377), May also have a role in cone synapse formation (PubMed:25997951, PubMed:28334377), Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (By similarity), Could be a regulator of the FGFRs (By similarity)


This is T cell receptor beta variable 19 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is T cell receptor alpha variable 27 protein, from Human, contains 109 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is MHC class I-like protein MILL2 protein, from Rat, contains 372 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds to heparan sulfate proteoglycans on the surface of fibroblast cells


This is T cell receptor beta variable 6-5 protein, from Human, contains 114 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is DEAD-box ATP-dependent RNA helicase 3A, chloroplastic protein, from Maize, contains 745 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Nuclear genome-encoded factor involved in ribosome biogenesis in chloroplasts, Binds specific group II introns in chloroplasts and facilitates their splicing, Required for normal development of chloroplasts

Belongs to the DEAD box helicase family, DDX21/DDX50 subfamily


This is Protein PHOTOSYSTEM I ASSEMBLY 2, chloroplastic protein, from Maize, contains 196 amino acids, has 1 CR-type Zinc finger.

CR-type

Nuclear genome-encoded factor required for the accumulation of photosystem I (PSI) during plant development, May form a complex with PSAG and mediate thiol transactions in the thylakoid lumen that are important for the assembly of PSI, Possesses protein-disulfide reductase activity in vitro


This is Peroxisome assembly protein 10-A protein, from African clawed frog, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:35931083), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is Peroxisome assembly protein 10-B protein, from African clawed frog, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Peroxisome biogenesis factor 2 protein, from African clawed frog, contains 306 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:35931083), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane, PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity)


This is Protein ZAR1-like 1.S protein, from African clawed frog, contains 281 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:36278895), Controls timing of meiosis during oogenesis (PubMed:36278895), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (PubMed:36278895)

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is Zinc finger protein somi-1 protein, from Caenorhabditis elegans, contains 582 amino acids, has 1 C2H2-type; Degenerate Zinc finger.

C2H2-type; Degenerate

DNA-binding protein which binds to the promoters of let-60, lin-14 and lin-28, possibly to regulate genes involved in hypodermal and vulval development (PubMed:21979920), Together with miRNAs mir-84 and let-7 may direct terminal differentiation of the seam cells, exit from the molting cycle, and vulva formation (PubMed:21979920), Does not regulate the expression of mir-84 (PubMed:21979920), May promote hypodermal differentiation in association with swsn-9, a component of SWI/SNF chromatin remodeling complexes (PubMed:21979920)


This is T cell receptor beta constant 2 protein, from Human, contains 178 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Constant region of T cell receptor (TR) beta chain (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is Tyrosine-protein kinase receptor TYRO3 protein, from Western clawed frog, contains 881 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be involved in cell adhesion processes, particularly in the central nervous system

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Ubiquitin carboxyl-terminal hydrolase 20 protein, from Western clawed frog, contains 884 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2), Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2, Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)

Belongs to the peptidase C19 family, USP20/USP33 subfamily


This is E3 ubiquitin-protein ligase MARCHF3 protein, from Bovine, contains 253 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is E3 ubiquitin-protein ligase TRIM11 protein, from Bovine, contains 468 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX, Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis, May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences, May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity), Mediates MED15 ubiquitination leading to proteasomal degradation, May contribute to the innate restriction of retroviruses, Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression, Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain, May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle, Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2, Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity)


This is Zinc finger and BTB domain-containing protein 18 protein, from Bovine, contains 522 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development, Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes, Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis, Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons, May also play a role in the organization of chromosomes in the nucleus (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily


This is Zinc finger protein 57 protein, from Rat, contains 406 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 3 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 5; degenerate

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation, Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs), Acts together with ZNF445, Required for the establishment of maternal methylation imprints at SNRPN locus, Acts as a transcriptional repressor in Schwann cells, Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Immunoglobulin lambda constant 7 protein, from Human, contains 106 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Constant region of immunoglobulin light chains, Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)


This is Nuclear receptor subfamily 6 group A member 1 protein, from Pig, contains 479 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds to a response element containing the sequence 5'-TCAAGGTCA-3', May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity)

Belongs to the nuclear hormone receptor family, NR6 subfamily


This is Formamidopyrimidine-DNA glycosylase protein, from Mycobacterium smegmatis, contains 285 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Acts on oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG) when paired with C, G or T, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is DNA repair protein RadA protein, from Mycobacterium smegmatis, contains 466 amino acids, has 1 C4-type Zinc finger.

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks, Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster, Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB, Does not have RecA's homology-searching function (By similarity), Also inhibits the diadenylate cyclase activity of DisA (PubMed:23760274)

Belongs to the RecA family, RadA subfamily


This is Splicing factor U2AF 35 kDa subunit protein, from Bovine, contains 237 amino acids, has 2 C3H1-type Zinc finger.

Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection, Recruits U2 snRNP to the branch point, Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity)

Belongs to the splicing factor SR family


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107), contains 728 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)

Belongs to the Dus family, Dus3 subfamily


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Aspergillus fischerianus, contains 726 amino acids, has 2 C3H1-type Zinc finger.


This is Baculoviral IAP repeat-containing protein 3 protein, from Dog, contains 604 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis, Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling, The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10, Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs), Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner, Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8


This is Fas apoptotic inhibitory molecule 3 protein, from Mouse, contains 422 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

May play a role in the immune system processes, Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL, Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream, May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity)


This is RNA-binding protein MEX3A protein, from Human, contains 520 amino acids, has 1 RING-type Zinc finger.

RING-type

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms


This is PAN2-PAN3 deadenylation complex subunit pan3 protein, from Western clawed frog, contains 787 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP), PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins

Belongs to the protein kinase superfamily, PAN3 family


This is E3 ubiquitin-protein ligase RING1 protein, from Western lowland gorilla, contains 377 amino acids, has 1 RING-type Zinc finger.

RING-type

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation, H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility, Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity)


This is Zinc finger protein 16 protein, from Western lowland gorilla, contains 682 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 15 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

Acts as a transcriptional activator, Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase, Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively, Also plays a role as an inhibitor of cell apoptosis (By similarity)


This is Fc receptor-like protein 6 protein, from Mouse, contains 268 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Acts as a MHC class II receptor, When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells, Does not act as an Fc receptor


This is Zinc finger and BTB domain-containing protein 7C protein, from Human, contains 619 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 4; degenerate


This is Zinc finger protein 69 protein, from Mouse, contains 587 amino acids, has 9 C2H2-type Zinc finger.

Putative transcription factor that appears to regulate lipid metabolism


This is TANK-binding kinase 1-binding protein 1 protein, from Mouse, contains 611 amino acids, has 1 UBZ1-type Zinc finger.

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity, Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513), contains 748 amino acids, has 2 C3H1-type Zinc finger.


This is E3 ubiquitin-protein ligase RING1 protein, from Chimpanzee, contains 377 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Zinc finger protein 16 protein, from Chimpanzee, contains 682 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 15 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate


This is Retinoic acid receptor RXR-alpha-A protein, from Zebrafish, contains 430 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid that acts as a transcription factor, Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription, The high affinity ligand for rxrs is 9-cis retinoic acid, In the absence of ligand, the rar/rxr heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression, On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is E3 ubiquitin-protein ligase BRE1-like 1 protein, from Rice, contains 884 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1, H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me, It thereby plays a central role in histone code and gene regulation, Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6


This is E3 ubiquitin-protein ligase BRE1-like 2 protein, from Rice, contains 844 amino acids, has 1 RING-type Zinc finger.

RING-type


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yeast, contains 613 amino acids, has 2 C3H1-type Zinc finger.


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha protein, from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338), contains 568 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity)

In the C-terminal section; belongs to the AccA family


This is Peroxisome assembly protein 12 protein, from Bovine, contains 359 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is Hepatic and glial cell adhesion molecule protein, from Bovine, contains 418 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Involved in regulating cell motility and cell-matrix interactions, May inhibit cell growth through suppression of cell proliferation (By similarity)


This is E3 ubiquitin-protein ligase GW2 protein, from Rice, contains 425 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase involved in the regulation of grain size, May limit grain width and weight by restricting cell proliferation of the spikelet hull, Possesses E3 ubiquitin-protein ligase activity in vitro


This is Tripartite motif-containing protein 2 protein, from Bovine, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11, Plays a neuroprotective function, May play a role in neuronal rapid ischemic tolerance, Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Rice blast fungus, contains 739 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)


This is Sodium channel subunit beta-1 protein, from Chimpanzee, contains 218 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle, Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation, Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A

Belongs to the sodium channel auxiliary subunit SCN1B (TC 8,A,17) family


This is CMRF35-like molecule 9 protein, from Bovine, contains 255 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Receptor which may mediate L-selectin-dependent lymphocyte rollings, Binds SELL in a calcium dependent manner, Binds lymphocyte (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yeast, contains 607 amino acids, has 2 C3H1-type Zinc finger.


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yeast, contains 642 amino acids, has 2 C3H1-type Zinc finger.


This is Large T antigen protein, from WUPyV, contains 648 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription


This is E3 ubiquitin-protein ligase RNF144B protein, from Bovine, contains 304 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation, Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism, However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By similarity)

Belongs to the RBR family, RNF144 subfamily


This is Ubiquitin carboxyl-terminal hydrolase 33 protein, from Zebrafish, contains 897 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling, Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate, Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling, Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2), Deubiquitinates dio2, thereby regulating thyroid hormone regulation, Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)


This is E3 ubiquitin-protein ligase CHFR protein, from Zebrafish, contains 637 amino acids, has 1 RING-type Zinc finger, has 1 PBZ-type Zinc finger.

RING-type

PBZ-type

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons, Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus, Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome, May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress


This is E3 ubiquitin-protein ligase znrf3 protein, from Zebrafish, contains 868 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (PubMed:22575959), Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)


This is Ubiquitin carboxyl-terminal hydrolase 22 protein, from Zebrafish, contains 506 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA, Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator, Recruited to specific gene promoters by activators, where it is required for transcription (By similarity)

Belongs to the peptidase C19 family, UBP8 subfamily


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Elephant's foot yam, contains 489 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is RAS guanyl-releasing protein 2 protein, from Bovine, contains 608 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP, May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS, Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation, May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway


This is Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 protein, from Human, contains 550 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Ret finger protein-like 4A protein, from Human, contains 287 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate


This is Sialic acid-binding Ig-like lectin 16 protein, from Human, contains 481 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is E3 ubiquitin-protein ligase MARCHF11 protein, from Human, contains 402 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, May play a role in ubuquitin-dependent protein sorting in developmenting spermatids


This is HEPACAM family member 2 protein, from Bovine, contains 491 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Required during prometaphase for centrosome maturation, Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Darling's disease fungus, contains 741 amino acids, has 2 C3H1-type Zinc finger.


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Noble rot fungus, contains 750 amino acids, has 2 C3H1-type Zinc finger.


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Baker's yeast, contains 668 amino acids, has 2 C3H1-type Zinc finger.


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from White mold, contains 750 amino acids, has 2 C3H1-type Zinc finger.


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Common dodder, contains 491 amino acids, has 1 C4-type Zinc finger.


This is Semaphorin-3C protein, from Bovine, contains 751 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to plexin family members and plays an important role in the regulation of developmental processes, Required for normal cardiovascular development during embryogenesis, Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Kluyveromyces polysporus, contains 664 amino acids, has 2 C3H1-type Zinc finger.


This is Insulinoma-associated protein 1 protein, from African clawed frog, contains 433 amino acids, has 4 C2H2-type Zinc finger.

May act as a transcriptional regulator (By similarity), Plays a role in noradrenergic neuron, pancreatic and gastrointestinal endocrine cells differentiation during embryonic development


This is Progesterone receptor protein, from Chimpanzee, contains 933 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcriptional activator of several progesteron-dependent promoters in a variety of cell types, Involved in activation of SRC-dependent MAPK signaling on hormone stimulation

Belongs to the nuclear hormone receptor family


This is Progesterone receptor protein, from Pygmy chimpanzee, contains 933 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Bornean orangutan, contains 935 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Lar gibbon, contains 932 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Barbary macaque, contains 935 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Olive baboon, contains 933 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Green monkey, contains 933 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Mantled guereza, contains 934 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Dusky leaf-monkey, contains 933 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Selection and upkeep of intraepithelial T-cells protein 7 protein, from Mouse, contains 395 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus


This is Selection and upkeep of intraepithelial T-cells protein 8 protein, from Mouse, contains 398 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type


This is Progesterone receptor protein, from Brown-capped capuchin, contains 935 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Gray monk saki, contains 935 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Progesterone receptor protein, from Black spider monkey, contains 935 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Aprataxin and PNK-like factor protein, from Fruit fly, contains 255 amino acids, has 2 PBZ-type Zinc finger.

PBZ-type

PBZ-type

Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro


This is ERI1 exoribonuclease 2 protein, from Human, contains 691 amino acids, has 1 GRF-type Zinc finger.

GRF-type


This is Transcription factor IIIB 50 kDa subunit protein, from Zebrafish, contains 423 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase III transcription, Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites, Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress, Down-regulates expression of target genes in response to oxidative stress, Overexpression protects cells against apoptosis in response to oxidative stress


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha protein, from Frankia sp. (strain EAN1pec), contains 614 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity)


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha protein, from Salinispora arenicola (strain CNS-205), contains 566 amino acids, has 1 C4-type Zinc finger.


This is V-set and transmembrane domain-containing protein 5 protein, from Human, contains 200 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics, Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia, In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution, Promotes formation of unstable neuronal spines such as thin and branched types, Regulates neuronal morphogenesis and migration during cortical development in the brain


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Inky cap fungus, contains 676 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Dandruff-associated fungus, contains 766 amino acids, has 2 C3H1-type Zinc finger.


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Rigid hornwort, contains 491 amino acids, has 1 C4-type Zinc finger.


This is Rab effector MyRIP protein, from Zebrafish, contains 838 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May link secretory vesicles to actin filaments (By similarity), May function as a protein kinase A-anchoring protein (AKAP), May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis (By similarity)


This is Serine/threonine-protein kinase dkf-1 protein, from Caenorhabditis briggsae, contains 760 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC, Role in the regulation of growth and neuromuscular control of movement, Involved in immune response to S,aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is E3 ubiquitin-protein ligase hrd-1 protein, from Caenorhabditis briggsae, contains 622 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation, Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins, Also promotes the degradation of normal but naturally short-lived proteins, Protects cells from ER stress-induced apoptosis, Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation (By similarity)


This is Large T antigen protein, from Squirrel monkey polyomavirus, contains 655 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription


This is RanBP-type and C3HC4-type zinc finger-containing protein 1 protein, from Zebrafish, contains 714 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity), LUBAC conjugates linear polyubiquitin to ikbkg and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity), Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity), LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) to conjugate linear polyubiquitin to ikbkg and possibly other components contributing to the stability of the complex (By similarity), The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity), LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity), The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity), Binds polyubiquitin of different linkage types (By similarity)


This is Baculoviral IAP repeat-containing protein 7 protein, from Western clawed frog, contains 365 amino acids, has 1 RING-type Zinc finger.

RING-type

Weak apoptotic suppressor, Has E3 ubiquitin-protein ligase activity, Weak inhibitor of caspase activity


This is Speckle targeted PIP5K1A-regulated poly(A) polymerase protein, from Western clawed frog, contains 843 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs, In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs, In addition to adenylyltransferase activity, also has uridylyltransferase activity, However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase

Belongs to the DNA polymerase type-B-like family


This is Zinc finger protein DPF3 protein, from Zebrafish, contains 391 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology), Specifically binds acetylated lysines on histone 3 and 4, In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling, Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity), Plays an essential role in heart and skeletal muscle development


This is Baculoviral IAP repeat-containing protein 7-B protein, from African clawed frog, contains 345 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Formamidopyrimidine-DNA glycosylase protein, from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl), contains 278 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Putative RNA polymerase II subunit B1 CTD phosphatase rpap2 protein, from Zebrafish, contains 601 amino acids, has 1 RTR1-type Zinc finger.

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes, Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity), Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity)


This is Peroxisome biogenesis factor 10 protein, from Mouse, contains 324 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is Zinc finger CCHC domain-containing protein 7 protein, from Mouse, contains 541 amino acids, has 4 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type


This is E3 ubiquitin-protein ligase arih1 protein, from Western clawed frog, contains 529 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3, Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets, The initial ubiquitin is then elongated, E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes

Belongs to the RBR family, Ariadne subfamily


This is Ubiquitin thioesterase zranb1 protein, from Western clawed frog, contains 701 amino acids, has 3 RanBP2-type Zinc finger.

Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity), Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity), Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity), Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity), Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity), Required in the stress fiber dynamics and cell migration (By similarity)


This is Ubiquitin carboxyl-terminal hydrolase 20 protein, from African clawed frog, contains 840 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2), Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2, Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)

Belongs to the peptidase C19 family, USP20/USP33 subfamily


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha protein, from Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF), contains 605 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity)


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Stenotrophomonas maltophilia (strain K279a), contains 291 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Zinc finger protein 382 protein, from Mouse, contains 579 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 9 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Functions as a sequence-specific transcriptional repressor

Belongs to the krueppel C2H2-type zinc-finger protein family


This is PHD finger protein ING2 protein, from Mouse-ear cress, contains 262 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Interference hedgehog protein, from Fruit fly, contains 880 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc)

Belongs to the immunoglobulin superfamily, IHOG family


This is Interference hedgehog protein, from Fruit fly, contains 879 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Zinc finger protein 76 protein, from Rat, contains 568 amino acids, has 7 C2H2-type Zinc finger.

May be involved in transcriptional regulation


Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Interference hedgehog protein, from Hawaiian fruit fly, contains 888 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Interference hedgehog protein, from Fruit fly, contains 897 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Interference hedgehog protein, from Fruit fly, contains 907 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Interference hedgehog protein, from Fruit fly, contains 881 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is SAGA-associated factor 11 homolog 2 protein, from Fruit fly, contains 228 amino acids, has 1 SGF11-type Zinc finger.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination, Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B, The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription, Required for nuclear receptor-mediated transactivation, Binds independently on SAGA to promoters in an RNA-dependent manner, Binds to mRNA and is essential for total mRNA export from the nucleus, Required to counteract heterochromatin silencing, Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe, Required for expression of ecdysone-induced genes such as br/broad


This is GATA-type transcription factor SRE1 protein, from Darling's disease fungus, contains 630 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence element 5'-(G/A)ATC(T/A)GATAA-3' of target promoters in an iron- and zinc-dependent manner (PubMed:18549241, PubMed:22117028), Regulation occurs via direct binding of iron ions (PubMed:18549241), Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity) (PubMed:22117028), SRE1 targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis, presumed ferric reductase activity, iron-responsive transcriptional regulation, oxidative stress response, as well as genes encoding a number of putative oxidoreductases, metabolic and mitochondrial enzymes, superoxide dismutase, and genes previously identified as induced during nitrosative stress (PubMed:22117028)


This is AN1-type zinc finger protein 5 protein, from Rat, contains 213 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger.

Involved in protein degradation via the ubiquitin-proteasome system, May act by anchoring ubiquitinated proteins to the proteasome, Plays a role in ubiquitin-mediated protein degradation during muscle atrophy, Plays a role in the regulation of NF-kappa-B activation and apoptosis, Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA, Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner, Overexpression sensitizes cells to TNF-induced apoptosis, Is a potent inhibitory factor for osteoclast differentiation (By similarity)


This is Interleukin-1 receptor accessory protein-like 1-A protein, from Zebrafish, contains 701 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel, During presynaptic differentiation may regulate both synaptic vesicle accumulation in axon terminals and subsequent axon terminal remodeling

Belongs to the interleukin-1 receptor family


This is Modifier of cell death protein, from Caenorhabditis elegans, contains 901 amino acids, has 1 C2H2-type Zinc finger.

Promotes programmed cell death, Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins dpl-1 and lin-35, and is independent of the ced-1, ced-8 and ced-9 pathways


This is UvrABC system protein A protein, from Escherichia coli O127:H6 (strain E2348/69 / EPEC), contains 940 amino acids, has 2 C4-type Zinc finger.

Plays a role in recovery after DNA ADP-ribosylation

Belongs to the ABC transporter superfamily, UvrA family


This is Transcription factor coe2-B protein, from African clawed frog, contains 580 amino acids, has 1 C5-type Zinc finger.

May play a pivotal role in the transcriptional cascade that specifies primary neurons in embryos, Stabilizes the higher neural potential of selected progenitor cells that express neurog2/X-ngnr-1 by maintaining Delta-Notch signaling, Thus ensures the transition between neural competence and irreversible commitment to a neural fate, Also promotes neuronal differentiation by activating neurod1 expression, directly or indirectly


This is DNA replication licensing factor MCM2 protein, from Rice, contains 961 amino acids, has 1 C4-type Zinc finger.

Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells


This is Squamosa promoter-binding-like protein 13A protein, from Mouse-ear cress, contains 359 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'


This is E3 ubiquitin-protein ligase GW2 protein, from Rice, contains 425 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase involved in the regulation of grain size, May limit grain width and weight by restricting cell proliferation of the spikelet hull, Possesses E3 ubiquitin-protein ligase activity in vitro


This is Zinc finger BED domain-containing protein RICESLEEPER 1 protein, from Rice, contains 722 amino acids, has 1 BED-type Zinc finger.

BED-type

Transposase-like protein that is essential for plant growth and development, May regulate global gene expression by recruiting other cellular factors


This is Probable DNA helicase MCM8 protein, from Rice, contains 789 amino acids, has 1 C4-type Zinc finger.

Probable DNA helicase that may play a role in DNA repair during meiosis


This is Probable Histone-lysine N-methyltransferase ATXR5 protein, from Castor bean, contains 374 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone methyltransferase that specifically monomethylates 'Lys-27' of histone H3 (H3K27me1), Has much higher activity on nucleosomes containing H3,1 than H3,3, Involved in the formation of constitutive heterochromatin and the silencing of heterochromatic elements

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is E3 ubiquitin-protein ligase rnf146 protein, from Atlantic salmon, contains 349 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins, Neuroprotective protein, Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest, Promotes cell survival after gamma-irradiation, Facilitates DNA repair


This is Leukocyte immunoglobulin-like receptor subfamily B member 3B protein, from Rat, contains 744 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May act as receptor for class I MHC antigens, Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor, Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)


This is Peroxisome biogenesis factor 10 protein, from Caenorhabditis elegans, contains 314 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5/prx-5 receptor from peroxisomes to the cytosol, thereby promoting PEX5/prx-5 recycling (PubMed:20176933) (Probable), The retrotranslocation channel is composed of PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5/prx-5 through the peroxisomal membrane (By similarity), PEX10/prx-10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity), When PEX5/prx-5 recycling is compromised, PEX10/prx-10 catalyzes polyubiquitination of PEX5/prx-5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Bacillus subtilis (strain 168), contains 290 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Zygote arrest protein 2.S protein, from African clawed frog, contains 302 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:22732570), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (PubMed:22732570)


This is Lysine-specific demethylase JMJ26 protein, from Mouse-ear cress, contains 875 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type; degenerate Zinc finger.

RING-type; degenerate

B box-type; degenerate

May function as histone H3 lysine demethylase and be involved in regulation of gene expression

Belongs to the JARID1 histone demethylase family


This is B-box zinc finger protein 19 protein, from Mouse-ear cress, contains 183 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Acts as negative regulator of seedling photomorphogenesis


This is N-lysine methyltransferase SMYD2 protein, from Pig, contains 433 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha protein, from Eubacterium rectale, contains 589 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity)


This is Netrin receptor UNC5B-b protein, from African clawed frog, contains 942 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Plays a role in cell-cell adhesion during embryonic development (PubMed:19492039), Receptor for netrin required for axon guidance, Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity)


This is DNA topoisomerase 3-alpha protein, from Rice, contains 928 amino acids, has 1 C4-type Zinc finger, has 1 GRF-type Zinc finger, has 1 CCHC-type Zinc finger.

GRF-type

CCHC-type

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone, Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells (By similarity)

Belongs to the type IA topoisomerase family


This is Tripartite motif-containing protein 2 protein, from Giant panda, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11, Plays a neuroprotective function, May play a role in neuronal rapid ischemic tolerance, Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity


This is E3 ubiquitin-protein ligase RNF146 protein, from Giant panda, contains 359 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex, Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2, Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation, Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48', May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location, Neuroprotective protein (By similarity), Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity), Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity), Does not affect PARP1 activation, Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity), Promotes cell survival after gamma-irradiation, Facilitates DNA repair (By similarity)


This is E3 ubiquitin-protein ligase RNF152 protein, from Giant panda, contains 203 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation, Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability, Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation, Induces apoptosis when overexpressed


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 3 protein, from Giant panda, contains 628 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Promotes neurite outgrowth in hippocampal neurons (By similarity)


This is E3 ubiquitin-protein ligase RNF187 protein, from Rat, contains 236 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8


This is E3 ubiquitin-protein ligase RNF182 protein, from Rat, contains 247 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway, Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA


This is U1 small nuclear ribonucleoprotein C protein, from Rat, contains 159 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region

Belongs to the U1 small nuclear ribonucleoprotein C family