This is Proto-oncogene vav protein, from Mouse, contains 845 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation


This is Interleukin-1 receptor type 2 protein, from Human, contains 398 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Non-signaling receptor for IL1A, IL1B and IL1RN, Reduces IL1B activities, Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1, Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B, IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN, The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

Belongs to the interleukin-1 receptor family


This is Interleukin-1 receptor type 2 protein, from Mouse, contains 410 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Non-signaling receptor for IL1A, IL1B and IL1RN, Reduces IL1B activities, Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1, Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B, IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN, The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity)


This is Gag polyprotein protein, from SIV-agm.ver, contains 520 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Gag polyprotein protein, from SIV-agm.ver, contains 521 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is DNA-directed RNA polymerase II subunit RPB9 protein, from Baker's yeast, contains 122 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template, Involved in the regulation of transcription elongation, Involved in DNA repair of damage in the transcribed strand, Mediates a transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER)

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is HLA class II histocompatibility antigen, DM alpha chain protein, from Human, contains 261 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides, In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO


This is HLA class II histocompatibility antigen, DM beta chain protein, from Human, contains 263 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class II histocompatibility antigen, M alpha chain protein, from Mouse, contains 261 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides


This is mRNA export factor protein, from HHV-2, contains 512 amino acids, has 1 CHC2-type Zinc finger.

Multifunctional regulator of the expression of viral genes that contributes to the shutoff of host protein synthesis and mediates nuclear export of viral intronless mRNAs, Also stimulates translation of viral transcripts (PubMed:25540385), Independently, plays a role in the regulation of virion release (PubMed:25540385), Also plays a role in the inhibition of host innate immune response by targeting host IRF3 and therby preventing production of beta-interferon (PubMed:30863402), Silences the 3' splice site of the host promyelocytic leukemia (PML) intron 7a, thereby switching PML isoforms from PML-II to PML-V, This could be linked to the accelerated mRNA export induced by ICP27 which might not provide sufficient time for PML pre-mRNA to be spliced in the nucleus (PubMed:19729513), Suppresses also splicing of the viral ICP34,5 mRNA, allowing the virus to express a variant form of ICP34,5 (PubMed:23487469)

Belongs to the HHV-1 ICP27 protein family


This is Peroxisome biogenesis factor 2 protein, from Human, contains 305 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity), PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity), Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (PubMed:27597759), Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883)


This is Transcription factor elt-1 protein, from Caenorhabditis elegans, contains 416 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof (PubMed:19591818, PubMed:21829390), During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage (PubMed:9224715, PubMed:16303852, PubMed:11259601), The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres (PubMed:9224715), Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion (PubMed:16303852), Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif (PubMed:21829390), Probably represses expression of eff-1 to prevent fusion of seam cells with the hypodermal syncytium (PubMed:21829390), Involved in regulating expression of elt-3, a probable downstream target in hypodermal development pathways, in dorsal and ventral hypodermal cells (PubMed:16303852, PubMed:11259601), During postembryonic development, has a role in sperm development (PubMed:19591818, PubMed:29702639), Specifically, binds the bipartite consensus sequence 5'-AGATCTx(8)GATAA-3' found in genes with sperm-specific expression (PubMed:19591818), Furthermore, regulates timing of developmental steps, possibly in parallel with daf-12, by controlling the expression of the let-7 family of miRNAs which in turn determines the transcription of heterochronic genes such as lin-41 (PubMed:25816370)


This is DNA repair protein RAD14 protein, from Baker's yeast, contains 371 amino acids, has 1  Zinc finger.

Involved in nucleotide excision repair, Binds specifically to damaged DNA, Required for the incision step


This is Myeloid zinc finger 1 protein, from Human, contains 734 amino acids, has 13 C2H2-type Zinc finger.

Binds to target promoter DNA and functions as transcription regulator, Regulates transcription from the PADI1 and CDH2 promoter, May be one regulator of transcriptional events during hemopoietic development

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Retinoic acid receptor RXR-alpha protein, from Mouse, contains 467 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid that acts as a transcription factor (PubMed:10383391, PubMed:12032153, PubMed:25417649), Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:1310259, PubMed:10383391), The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:1310259), The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:10383391, PubMed:25417649), In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity), On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity), Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:1310259), The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (By similarity), The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (By similarity), Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity), Acts as an enhancer of RARA binding to RARE DNA element (By similarity), May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (By similarity), Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675), Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649), Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Retinoic acid receptor RXR-gamma protein, from Chicken, contains 467 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)


This is Retinoic acid receptor RXR-beta protein, from Human, contains 533 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)


This is Retinoic acid receptor RXR-beta protein, from Mouse, contains 520 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Retinoic acid receptor RXR-gamma protein, from Mouse, contains 463 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Protein kinase C delta type protein, from Mouse, contains 674 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses, Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (PubMed:11976686, PubMed:11976687), Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis, In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53, In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53, In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9, Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway, Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis, Is required for the control of cell cycle progression both at G1/S and G2/M phases, Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity, In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (PubMed:19917613), Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1, Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA (By similarity), In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:18025218), Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:22265677), May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA, In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation, Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release, Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin, The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (PubMed:9705322), Phosphorylates ELAVL1 in response to angiotensin-2 treatment (By similarity), Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (By similarity), Phosphorylates SMPD1 which induces SMPD1 secretion (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is T-cell surface glycoprotein CD1b protein, from Human, contains 333 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells


This is T-cell surface glycoprotein CD1c protein, from Human, contains 333 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Transcription initiation factor IIB protein, from Fruit fly, contains 315 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II


This is Transcription initiation factor IIB protein, from Baker's yeast, contains 345 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type


This is Transcription factor IIIB 70 kDa subunit protein, from Baker's yeast, contains 596 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase III transcription, Interacts with TBP, Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC


This is General transcription factor IIE subunit 1 protein, from Human, contains 439 amino acids, has 1 C4-type Zinc finger.

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH, Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase

Belongs to the TFIIE alpha subunit family


This is E3 ubiquitin-protein ligase ICP0 protein, from BoHV-1, contains 676 amino acids, has 1 RING-type Zinc finger.

RING-type

Evades nuclear antiviral defenses triggered by dsDNA viruses, Acts during the initial stages of lytic infection and the reactivation of latent viral genome, Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100

Belongs to the simplexviruses ICp0 family


This is Gag polyprotein protein, from Murine leukemia virus (strain BM5 eco), contains 537 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome, Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome, This binding is dependent on genome dimerization


This is Interleukin-12 subunit beta protein, from Human, contains 328 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity, IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues, IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines, IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis


This is DNA replication licensing factor MCM2 protein, from Baker's yeast, contains 868 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; specifically the MCM2-MCM5 association is proposed to be reversible and to mediate a open ring conformation which may facilitate DNA loading, Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity, Necessary for cell growth


This is Protein neuralized protein, from Fruit fly, contains 754 amino acids, has 1 RING-type Zinc finger.

RING-type

Involved in neurogenesis, Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate


This is Vascular cell adhesion protein 1 protein, from Mouse, contains 739 amino acids, has 7 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation, Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins, During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration, Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation


This is Vascular cell adhesion protein 1 protein, from Rat, contains 739 amino acids, has 7 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Protein PML protein, from Human, contains 882 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

Exhibits antiviral activity against both DNA and RNA viruses, The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures, Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles, The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis, The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm, Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2), Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs, Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs, Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA, PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription, Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117), Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117)


This is Rano class II histocompatibility antigen, B-1 beta chain protein, from Rat, contains 263 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is Carbamoyltransferase HypF protein, from Escherichia coli (strain K12), contains 750 amino acids, has 2 C4-type Zinc finger.

Involved in the maturation of [NiFe] hydrogenases (PubMed:8661925, PubMed:12377778, PubMed:12586941), Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases (PubMed:12586941), HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide (PubMed:12586941, PubMed:15291820), In the absence of any other substrate, displays carbamoyl-phosphate phosphatase activity (PubMed:12377778)

Belongs to the carbamoyltransferase HypF family


This is Class I histocompatibility antigen, Gogo-A*0101 alpha chain protein, from Western lowland gorilla, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-A*0201 alpha chain protein, from Western lowland gorilla, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-A*0401 alpha chain protein, from Western lowland gorilla, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-A*0501 alpha chain protein, from Western lowland gorilla, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-B*0101 alpha chain protein, from Western lowland gorilla, contains 362 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-B*0102 alpha chain protein, from Western lowland gorilla, contains 362 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-B*0103 alpha chain protein, from Western lowland gorilla, contains 362 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-B*0201 alpha chain protein, from Western lowland gorilla, contains 363 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain protein, from Western lowland gorilla, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-C*0201 alpha chain protein, from Western lowland gorilla, contains 366 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-C*0202 alpha chain protein, from Western lowland gorilla, contains 366 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-C*0203 alpha chain protein, from Western lowland gorilla, contains 366 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, Gogo-OKO alpha chain protein, from Western lowland gorilla, contains 362 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is HLA class I histocompatibility antigen, alpha chain F protein, from Human, contains 346 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation, Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC), In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides, Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance, Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952), Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421), Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270), May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683), May play a role in inflammatory responses in the peripheral nervous system, Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464)


This is Saoe class I histocompatibility antigen, A alpha chain protein, from Cotton-top tamarin, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Class I histocompatibility antigen, B alpha chain protein, from Cotton-top tamarin, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Saoe class I histocompatibility antigen, C alpha chain protein, from Cotton-top tamarin, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Tyrosine-protein kinase receptor UFO protein, from Human, contains 894 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882), Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778), Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210)

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is DNA cross-link repair protein PSO2/SNM1 protein, from Baker's yeast, contains 661 amino acids, has 1 UBZ4-type Zinc finger.

Required for DNA interstrand cross-link repair, This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs), This protein has 5' exonuclease activity on single-stranded and double-stranded DNA, which appears to be necessary for the processing of DNA double strand breaks prior to ligation

Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family


This is DNA replication licensing factor mcm4-B protein, from African clawed frog, contains 863 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity


This is Patr class I histocompatibility antigen, C alpha chain protein, from Chimpanzee, contains 366 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is T-cell-specific surface glycoprotein CD28 protein, from Mouse, contains 218 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival, Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation


This is T-cell-specific surface glycoprotein CD28 protein, from Rat, contains 218 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is DNA repair protein RAD16 protein, from Baker's yeast, contains 790 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA, Involved in differential repair of DNA after UV damage, Will repair preferentially the MAT-alpha locus compared with the HML-alpha locus

Belongs to the SNF2/RAD54 helicase family


This is Probable nuclear hormone receptor HR3 protein, from Fruit fly, contains 487 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Putative receptor whose ligand is not yet known

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Hemolin protein, from Tobacco hawkmoth, contains 413 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Insect-immune protein with antimicrobial activity (PubMed:16731347), Forms a protein complex at the bacterial surface, Can inhibit hemocyte aggregation


This is Gag polyprotein protein, from Jaagsiekte sheep retrovirus, contains 612 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag-Pro polyprotein protein, from Jaagsiekte sheep retrovirus, contains 866 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Enhances the activity of the reverse transcriptase, May be part of the mature RT

In the C-terminal section; belongs to the dUTPase family


This is Gag polyprotein protein, from SIV-mac, contains 510 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1


This is Poly [ADP-ribose] polymerase 1 protein, from African clawed frog, contains 998 amino acids, has 2 PARP-type Zinc finger.

PARP-type

PARP-type

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (By similarity), Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units, Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity), Specificity for the different amino acids is conferred by interacting factors, such as hpf1 and nmnat1 (By similarity), Following interaction with hpf1, catalyzes serine ADP-ribosylation of target proteins; hpf1 confers serine specificity by completing the parp1 active site, Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with hpf1 (By similarity), Following interaction with nmnat1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; nmnat1 confers glutamate and aspartate specificity (By similarity), Parp1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits hpf1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks, In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair, Mediates the poly-ADP-ribosylation of a number of proteins, In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (By similarity), Parp1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity), In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (By similarity), Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II, Acts both as a positive and negative regulator of transcription elongation, depending on the context (By similarity), Poly-ADP-ribose chains generated by parp1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos, Also acts as a negative regulator of the cGAS-STING pathway by mediating poly-ADP-ribosylation and inactivation of cgas, Acts as a negative regulator of adipogenesis by catalyzing poly ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) (By similarity)


This is DnaJ homolog subfamily A member 1 protein, from Human, contains 397 amino acids, has 1 CR-type Zinc finger.

CR-type

Co-chaperone for HSPA8/Hsc70 (PubMed:10816573), Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877), Plays a role in protein transport into mitochondria via its role as co-chaperone, Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510), Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202)


This is Carcinoembryonic antigen-related cell adhesion molecule 1 protein, from Mouse, contains 521 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein

Belongs to the immunoglobulin superfamily, CEA family


This is Neural cell adhesion molecule 1 protein, from Bovine, contains 853 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc


This is Low affinity immunoglobulin gamma Fc region receptor II-b protein, from Human, contains 310 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma, Low affinity receptor, Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells, Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor, Isoform IIB1 fails to mediate endocytosis or phagocytosis, Isoform IIB2 does not trigger phagocytosis


This is Low affinity immunoglobulin gamma Fc region receptor II-c protein, from Human, contains 323 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the Fc region of complexed immunoglobulins gamma, Low affinity receptor, Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells


This is Carcinoembryonic antigen-related cell adhesion molecule 8 protein, from Human, contains 349 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190), Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190), Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764)


This is DDK kinase regulatory subunit DBF4 protein, from Baker's yeast, contains 704 amino acids, has 1 DBF4-type Zinc finger.

Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation, DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex, DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication, DDK has also postreplicative functions in meiosis, DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination, Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation, Inhibits CDC5 activity during mitosis through direct binding to its PBD


This is Zinc finger protein RME1 protein, from Baker's yeast, contains 300 amino acids, has 3 C2H2-type Zinc finger.

Involved in the control of meiosis, Represses the transcription of the IME1 gene thereby inhibiting cells from entering meiosis, But also activates the CLN2 gene thus promoting mitosis


This is Transcription factor SFP1 protein, from Baker's yeast, contains 683 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor that regulates ribosomal protein (RP) and ribosome biogenesis (Ribi) gene expression in response to nutrients and stress, Promotes RP gene expression under optimal growth conditions, Leaves the nucleus upon environmental challenges, resulting in a down-regulation of RP gene transcription, The effect of the environmental cues on SFP1 localization is mediated through the TOR pathway, Also regulates the expression of genes involved in the G2/M transition during the mitotic cell cycle and the DNA-damage response, Required for carbon-source modulation of cell size


This is Nuclear polyadenylated RNA-binding protein NAB2 protein, from Baker's yeast, contains 525 amino acids, has 7 C3H1-type Zinc finger.

Essential protein that binds to polyadenylated RNA and single-stranded DNA (PubMed:8474438), It may be involved not only in RNA processing but also in transcription regulation, Associates directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions (Probable), Involved in mRNA poly(A) tail length control and nuclear export (PubMed:11927564, PubMed:11779864), Functions in surveillance and the packaging leading to generation of export-competent mRNPs, Controls both mRNP compaction that facilitates movement through nuclear pore complexes and the length of transcript poly(A) tails (PubMed:19840948, PubMed:22560733)


This is Nectin-2 protein, from Mouse, contains 530 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Modulator of T-cell signaling, Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to, Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG, Upon interaction with PVRIG, inhibits T-cell proliferation, These interactions are competitive, Probable cell adhesion protein


This is DNA-directed RNA polymerase I subunit RPA12 protein, from Baker's yeast, contains 125 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors, Besides, RNA polymerase I has intrinsic RNA cleavage activity, Proposed to contribute to the polymerase catalytic activity and form the polymerase active center together with the two largest subunits, Subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I, Involved in transcriptional termination


This is Vacuolar segregation protein PEP7 protein, from Baker's yeast, contains 515 amino acids, has 1 C2H2-type Zinc finger, has 1 FYVE-type 1; atypical Zinc finger, has 1 FYVE-type Zinc finger.

FYVE-type 1; atypical

FYVE-type

Required for vacuole segregation and vacuole protein sorting, Possibly part of a complex which tethers the vacuole membrane to microtubules, either directly or via kinesin or dynein-like motor proteins, Probably functions in several interorganelle traffic pathways


This is Peroxisomal biogenesis factor 2 protein, from Baker's yeast, contains 271 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:19687296, PubMed:22471590, PubMed:35768507), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507), PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (PubMed:35768507), PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (PubMed:35768507)


This is Transcription elongation factor SPT4 protein, from Baker's yeast, contains 102 amino acids, has 1 C4-type Zinc finger.

The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing, The complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene, Structural and functional component of the centromeric and heterochromatic loci linking chromatin structure with kinetochore function and gene silencing


This is Intercellular adhesion molecule 3 protein, from Human, contains 547 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173), ICAM3 is also a ligand for integrin alpha-D/beta-2, In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590)

Belongs to the immunoglobulin superfamily, ICAM family


This is Steroidogenic factor 1 protein, from Mouse, contains 462 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator, Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues, Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B, Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes, 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1, The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity), Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells, Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate, Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is pH-response transcription factor pacC/RIM101 protein, from Baker's yeast, contains 625 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH, At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes, Required for meiosis, sporulation and invasive growth


This is Mamu class I histocompatibility antigen, alpha chain F protein, from Rhesus macaque, contains 348 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is T-lymphocyte activation antigen CD80 protein, from Human, contains 288 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for adenovirus subgroup B


This is T-cell surface glycoprotein CD4 protein, from Dog, contains 463 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is Zinc finger protein MSN2 protein, from Baker's yeast, contains 704 amino acids, has 2 C2H2-type Zinc finger.

Positive transcriptional factor that acts as a component of the stress responsive system, Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc,), Involved in the regulation of the CTT1, DDR2, HSP12 genes, May be regulated via WHI2-PSR1 complex phosphatase activity


This is Ecdysone receptor protein, from Fruit fly, contains 878 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone (PubMed:1913820, PubMed:30293839), Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes (PubMed:1913820, PubMed:30293839)


This is Fasciclin-2 protein, from Fruit fly, contains 873 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles


This is Diacylglycerol kinase A protein, from Social amoeba, contains 887 amino acids, has 3 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids, Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes, Also plays an important role in the biosynthesis of complex lipids

Belongs to the eukaryotic diacylglycerol kinase family


This is Histone acetyltransferase SAS3 protein, from Baker's yeast, contains 831 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3, Recruitment of NuA3 to nucleosomes requires methylated histone H3, In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation, In vitro, SAS3 acetylates free histones H3 and H4, It is involved in silencing the HMR locus


This is Transcriptional regulatory protein ASH1 protein, from Baker's yeast, contains 588 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

Component of the RPD3C(L) histone deacetylase complex (HDAC), Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, ASH1 is necessary to repress HO in daughter cells to block mating-type switching through its binding to HO promoter 5'-YTGAT-3' sites, Also involved in pseudohyphal growth


This is DNA polymerase kappa protein, from Caenorhabditis elegans, contains 596 amino acids, has 1 UBZ4-type Zinc finger.

DNA polymerase specifically involved in DNA repair, Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls, Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts, Lacks 3'-5' proofreading exonuclease activity, Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity)

Belongs to the DNA polymerase type-Y family


This is Zinc finger protein zfp-1 protein, from Caenorhabditis elegans, contains 867 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Required for migration of HSN motor neurons during embryogenesis


This is E3 ubiquitin-protein ligase bre-1 protein, from Caenorhabditis elegans, contains 837 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B (By similarity), H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (By similarity), Involved in regulating stem cell proliferative fate (PubMed:25564623)


This is B-box type zinc finger protein ncl-1 protein, from Caenorhabditis elegans, contains 851 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

B box-type 1; atypical

B box-type

Translational repressor that inhibits protein synthesis (PubMed:9508766, PubMed:26492166), Represses the translation of mRNAs such as fib-1, probably by being recruited by RNA-binding protein nos-2 and the Pumilio proteins puf-5, puf-8 and puf-9 to the consensus core PUF binding motif in the 3'-UTR of fib-1 mRNA (PubMed:26492166), Negatively regulates ribosomal RNA (rRNA) synthesis, ribosomal protein synthesis and nucleolus size (PubMed:9508766, PubMed:8582642, PubMed:22768349, PubMed:26492166, PubMed:28853436), Its role in the negative regulation of nucleolus size is most likely through its negative regulation of the translation of proteins such as the rRNA 2'-O-methyltransferase fib-1, and dao-5 (PubMed:26492166, PubMed:28853436), Might act directly as a transcription factor to inhibit RNA polymerase I (rRNA) and III (5S RNA) transcription (PubMed:9508766), Plays a role in embryonic development, and in particular, is involved in regulating the localization of proteins, such as par-2, that are required for embryonic cell polarity (PubMed:18652816), Plays a role in the regulation of lifespan, and the response to nutrient availability (PubMed:28853436)


This is ATP-dependent RNA helicase glh-1 protein, from Caenorhabditis elegans, contains 763 amino acids, has 4 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Probable ATP-binding RNA helicase (PubMed:8415696), May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos (PubMed:21402787, PubMed:24746798), Plays a role in positively regulating the localization of pgl-1 to P-granules (PubMed:18234720), May play a role in transgenerational epigenetic inheritance (PubMed:28533440), May protect somatic cells from excessive apoptosis during normal development (PubMed:27650246)

Belongs to the DEAD box helicase family, DDX4/VASA subfamily


This is Protein kinase C-like 1 protein, from Caenorhabditis elegans, contains 704 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable), Phosphorylates mlk-1, a component of the JNK pathway, Involved in axon regeneration after injury probably by activating the JNK pathway (PubMed:23072806), Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp-29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir-1-p38-like pathway (PubMed:22470487, PubMed:19380113), Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt, downstream of lin-3 and receptor let-23 and phospholipase plc-3 (PubMed:17891142)


This is Protein kinase C-like 1B protein, from Caenorhabditis elegans, contains 707 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins, PKC also serves as the receptor for phorbol esters, a class of tumor promoters, Involved in neuropeptide secretion in motor axons, Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in the signaling response to various sensory neurons; temperature, odor, taste, and osmolality, Its role in regulation differs depending on the neuron in which it is acting; thermosensation in AFD neurons, osmolality in ASH neurons, olfactory perception in AWA and AWC neurons, Promotes dauer formation mediated by the insulin/IGF pathway, Required for resistance to antimitotic toxins


This is Serine/threonine-protein kinase B-raf protein, from Japanese quail, contains 807 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Protein kinase involved in the activation of the MAP signaling cascade, May play a role in transducing specific signals in neural cells

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is General negative regulator of transcription subunit 4 protein, from Baker's yeast, contains 587 amino acids, has 1 RING-type Zinc finger, has 1 C3H1-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (PubMed:9463387, PubMed:30609991), The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes (PubMed:9463387), Preferentially affects TC-type TATA element-dependent transcription, Could directly or indirectly inhibit component(s) of the general transcription machinery (PubMed:9463387), In the cytoplasm, catalyzes monoubiquitination of RPS7/es7 in response to stalled ribosomes, initiating a HEL2-dependent response that activates the No-Go Decay (NGD) pathway (PubMed:30609991)


This is DnaJ homolog 1, mitochondrial protein, from Baker's yeast, contains 511 amino acids, has 1 CR-type Zinc finger.

CR-type

Plays a role in mitochondrial biogenesis and protein folding


This is ADP-ribosylation factor GTPase-activating protein GCS1 protein, from Baker's yeast, contains 352 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ARF1 and ARF2, Involved in intracellular vesicular transport, Required for transport from the trans-Golgi network, Implicated in the regulation of retrograde transport from the Golgi to the ER and in actin cytoskeletal organization, May be involved in the maintenance of mitochondrial morphology, possibly through organizing the actin cytoskeleton in Saccharomyces


This is Polycomb complex protein BMI-1 protein, from Human, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373), The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358), In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249)


This is Polycomb group RING finger protein 2 protein, from Human, contains 344 amino acids, has 1 RING-type Zinc finger.

RING-type

Transcriptional repressor, Binds specifically to the DNA sequence 5'-GACTNGACT-3', Has tumor suppressor activity, May play a role in control of cell proliferation and/or neural cell development, Regulates proliferation of early T progenitor cells by maintaining expression of HES1, Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity), Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332)


This is B-cell receptor CD22 protein, from Mouse, contains 868 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates B-cell B-cell interactions, May be involved in the localization of B-cells in lymphoid tissues, Binds sialylated glycoproteins; one of which is CD45, Preferentially binds to alpha-2,6-linked sialic acid, The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface, Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling, Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is Intercellular adhesion molecule 2 protein, from Mouse, contains 277 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion, It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance


This is Peroxisome proliferator-activated receptor delta protein, from Mouse, contains 440 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826), Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid, Once activated by a ligand, the receptor binds to promoter elements of target genes, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the acyl-CoA oxidase gene, Decreases expression of NPC1L1 once activated by a ligand (By similarity)


This is Nuclear receptor ROR-alpha protein, from Human, contains 523 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence, Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism, Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively, Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts, Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1, Required for proper cerebellum development (PubMed:29656859), Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction, Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1, Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression, Therefore influences the period length and stability of the clock, Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG, In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1, Induces a rhythmic expression of some of these genes, In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism, Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1, In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms, May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding, Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program, Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus, Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A, May inhibit cell growth in response to cellular stress, May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling


This is Glucocorticoid receptor protein, from Sheep, contains 314 amino acids, has 1 NR C4-type Zinc finger.

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Basigin protein, from Human, contains 385 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Ig-like V-type

(Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells


This is RNA-binding protein FUS protein, from Human, contains 526 amino acids, has 1 RanBP2-type Zinc finger.

DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383), Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092), Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307), Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410), In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity)


This is Protein MPE1 protein, from Baker's yeast, contains 441 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB


This is Class II histocompatibility antigen, M beta 1 chain protein, from Mouse, contains 261 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides


This is High affinity nerve growth factor receptor protein, from Rat, contains 799 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons, High affinity receptor for NGF which is its primary ligand (PubMed:1312719, PubMed:1850821), Can also bind and be activated by NTF3/neurotrophin-3, However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival, Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation, Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation, Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival, Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival, Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival, In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is Poly [ADP-ribose] polymerase protein, from Fruit fly, contains 994 amino acids, has 2 PARP-type Zinc finger.

PARP-type

PARP-type

Plays a fundamental role in organizing chromatin on a global scale (PubMed:12183365), Autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment (PubMed:12183365)


This is Gag polyprotein protein, from HIV-1, contains 500 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Tyrosine-protein kinase BTK protein, from Mouse, contains 659 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:7538439, PubMed:8629002, PubMed:10852954), Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity), After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (By similarity), PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (By similarity), BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (By similarity), Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:17725607), The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (By similarity), Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (By similarity), Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (By similarity), BTK also plays a critical role in transcription regulation (By similarity), Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (By similarity), BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (By similarity), Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188), Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:11120822, PubMed:16738337), GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:11120822, PubMed:16738337), ARID3A and NFAT are other transcriptional target of BTK (PubMed:11120822, PubMed:16738337), BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:11120822, PubMed:16738337), There is however no evidence that BTK itself binds directly to DNA (PubMed:11120822, PubMed:16738337), BTK has a dual role in the regulation of apoptosis (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Small ribosomal subunit protein eS27A protein, from Baker's yeast, contains 82 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eS27 family


This is Transmembrane E3 ubiquitin-protein ligase 1 protein, from Baker's yeast, contains 758 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Catalytic component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control (PubMed:25078903, PubMed:29355480), Mediates ubiquitination of vacuolar proteins such as CPS1, PPN1, PEP12 and other proteins containing exposed hydrophilic residues within their transmembrane domains, leading to their sorting into internal vesicles in late endosomes (PubMed:11788821), Targets also the unpalmitoylated endosomal SNARE TLG1 to the MVB pathway (PubMed:15973437)


This is Transcription initiation factor IIE subunit alpha protein, from Baker's yeast, contains 482 amino acids, has 1 C4-type Zinc finger.

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH, Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity)

Belongs to the TFIIE alpha subunit family


This is PAN2-PAN3 deadenylation complex subunit PAN3 protein, from Baker's yeast, contains 679 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1, PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress

Belongs to the protein kinase superfamily, PAN3 family


This is E3 ubiquitin-protein ligase HEL1 protein, from Baker's yeast, contains 551 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones, Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation


This is SET domain-containing protein 3 protein, from Baker's yeast, contains 751 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin, Required for both gene activation and repression, Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis, Required for the transcriptional activation of genes with high activity


This is E3 ubiquitin-protein ligase TRIM23 protein, from Human, contains 574 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type; degenerate Zinc finger.

RING-type; degenerate

B box-type; degenerate

(Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection

In the C-terminal section; belongs to the small GTPase superfamily, Arf family


This is E3 ubiquitin-protein ligase TRIM23 protein, from Rat, contains 573 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type; degenerate Zinc finger.

RING-type; degenerate

B box-type; degenerate

Acts as an E3 ubiquitin-protein ligase, Plays an essential role in autophagy activation during viral infection, Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1, In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes


This is Zinc finger protein 76 protein, from Human, contains 570 amino acids, has 7 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Protein kinase C-like 1 protein, from Fission yeast, contains 988 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Involved in the control of the cell shape, Target of the inhibitor staurosporine

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Receptor-type tyrosine-protein kinase FLT3 protein, from Human, contains 993 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells, Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR, Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1, Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B, Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B, Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is DNA-directed RNA polymerase II subunit RPB9 protein, from Human, contains 125 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity)

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is Peroxisome proliferator-activated receptor alpha protein, from Rat, contains 468 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Key regulator of lipid metabolism, Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC), Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety, Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the ACOX1 and P450 genes, Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2, May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Peroxisome proliferator-activated receptor gamma protein, from Human, contains 505 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

(Microbial infection) Upon treatment with M,tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein


This is Peroxisome proliferator-activated receptor gamma protein, from Mouse, contains 505 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase, It therefore controls the peroxisomal beta-oxidation pathway of fatty acids, Key regulator of adipocyte differentiation and glucose homeostasis, ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer, Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses, Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (PubMed:19041764)


This is Thyroid hormone receptor beta protein, from Mouse, contains 461 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine


This is T-cell surface antigen CD2 protein, from Horse, contains 347 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) to mediate adhesion between T-cells and other cell types, CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function


This is DNA-(apurinic or apyrimidinic site) endonuclease 2 protein, from Baker's yeast, contains 520 amino acids, has 1 GRF-type Zinc finger.

GRF-type

DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA

Belongs to the DNA repair enzymes AP/ExoA family


This is Ubiquitin carboxyl-terminal hydrolase 14 protein, from Baker's yeast, contains 781 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616), Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616), Accelerates proteasomal breakdown of ubiquitinated proteins as it disassembles free ubiquitin chains that would compete with ubiquitinated proteins to bind to the proteasome (PubMed:9305625)


This is Cytoplasmic 60S subunit biogenesis factor REI1 protein, from Baker's yeast, contains 393 amino acids, has 3 C2H2-type Zinc finger.

Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit, Involved in the dissociation and recycling of other late pre-60S factors like ARX1, TIF6 and ALB1 before newly synthesized large ribosomal subunits enter translation, Cooperates with the co-chaperone JJJ1 in the release of the nuclear-export factor ARX1, May act redundantly with REH1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on ARX1 recycling


This is E3 SUMO-protein ligase MMS21 protein, from Baker's yeast, contains 267 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Acts as an E3 ligase mediating SUMO/Smt3 attachment to SMC5 and YKU70, Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks


This is Transcription factor STP2 protein, from Baker's yeast, contains 541 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels, Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases BAP2 and BAP3, Binding to promoters is facilitated by DAL81 (By similarity), Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response, Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes


This is Small ribosomal subunit protein eS27B protein, from Baker's yeast, contains 82 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel


This is Chromatin modification-related protein YNG2 protein, from Baker's yeast, contains 282 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair, Involved in cell cycle progression and meiosis


This is E3 ubiquitin-protein ligase DMA1 protein, from Baker's yeast, contains 416 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes (PubMed:18202552), Involved in nutritional control of the cell cycle (PubMed:15319434), Targets the G1 cyclin PCL1 for destruction (PubMed:23264631), Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck (PubMed:15146058)


This is Endoplasmic reticulum junction formation protein lunapark protein, from Baker's yeast, contains 278 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Plays a role in tubular endoplasmic reticulum network formation and maintenance, Works in conjunction with the ER shaping proteins (reticulons RTN1 and RTN2, YOP1), and in antagonism to SEY1 to maintain the network in a dynamic equilibrium, May counterbalance SEY1-directed polygon formation by promoting polygon loss through ring closure


This is DNA-binding protein SMUBP-2 protein, from Human, contains 993 amino acids, has 1 AN1-type Zinc finger.

5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:30218034, PubMed:22999958), Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:8349627, PubMed:22999958), May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19299493, PubMed:19158098), May play a role in regulation of transcription (By similarity), Interacts with tRNA-Tyr (PubMed:19299493)

Belongs to the DNA2/NAM7 helicase family


This is Cyclin-dependent kinase inhibitor 1 protein, from Human, contains 164 amino acids, has 1 C4-type Zinc finger.

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage, Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression, Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1, At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex, Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739), Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657)


This is TNF receptor-associated factor 2 protein, from Mouse, contains 501 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis, Required for normal antibody isotype switching from IgM to IgG, Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1, Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases, Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain, Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity, Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR, In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE

Belongs to the TNF receptor-associated factor family, A subfamily


This is Cyclin-dependent kinase inhibitor 1 protein, from Mouse, contains 159 amino acids, has 1 C4-type Zinc finger.

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage, Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression, Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1, At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316), Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity), Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity)


This is Pair-rule protein odd-paired protein, from Fruit fly, contains 609 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 4 C2H2-type Zinc finger.

C2H2-type 1; atypical

Transcription factor essential for parasegmental subdivision of the embryo, It is involved in the activation of wingless (wg) in odd parasegments, It is also required for the timely activation of wg in the remaining parasegments and for the timely activation of engrailed (en) in all parasegments

Belongs to the GLI C2H2-type zinc-finger protein family


This is Transcription corepressor MIG3 protein, from Baker's yeast, contains 394 amino acids, has 2 C2H2-type Zinc finger.

DNA-binding transcriptional repressor involved in response to toxic agents such as ribonucleotide reductase inhibitor, hydroxyurea (HU)

Belongs to the creA/MIG C2H2-type zinc-finger protein family


This is DNA damage-responsive transcriptional repressor RPH1 protein, from Baker's yeast, contains 796 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Transcriptional repressor of photolyase PHR1, Recognizes and binds the sequence AG(4) in the upstream repressing sequence of PHR1, Derepresses PHR1 transcription when phosphorylated


This is JmjC domain-containing histone demethylation protein 1 protein, from Baker's yeast, contains 492 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code, Does not demethylate H3 'Lys-4' nor 'Lys-79'

Belongs to the JHDM1 histone demethylase family