This is SLAM family member 5 protein, from Mouse, contains 329 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:20962259), Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (PubMed:20962259), Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process, Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway, May serve as a marker for hematopoietic progenitor cells (By similarity), Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation (PubMed:20153220), In germinal centers involved in maintaining B cell tolerance and in preventing autoimmunity (PubMed:25801429), In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (By similarity), In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (PubMed:20628063), Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (By similarity)


This is Zinc finger protein unc-98 protein, from Caenorhabditis elegans, contains 310 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Probable transcription factor required for muscle structure (PubMed:12808046, PubMed:7348600), Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression (PubMed:12808046), Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role (PubMed:17158957), Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983)


This is Protein kinase C-like 3 protein, from Caenorhabditis elegans, contains 597 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Required for the normal progression of embryogenesis and viability of the organism (PubMed:9422779), Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3 (PubMed:9716526, PubMed:9834192), Required for epithelial cell polarity in the distal spermatheca (PubMed:15151982), Phosphorylates serine residues of num-1 (PubMed:11134025), Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury (PubMed:19380113)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Polycomb group RING finger protein 3 homolog mig-32 protein, from Caenorhabditis elegans, contains 549 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, throughout development (By similarity), Required for ubiquitination of histone H2A (PubMed:19211678), Plays a role in the formation of the male-specific genital sensilla (simple sense organs) known as rays (PubMed:19211678), Required for normal migration of the hermaphrodite specific neurons (HSN) and for extension of some neuronal processes (PubMed:19211678), Represses vulval fates in hypodermal cells that do not normally contribute to vulval development (PubMed:19211678)


This is Nuclear hormone receptor family member nhr-25 protein, from Caenorhabditis elegans, contains 572 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor and probable transcription activator, required during development (PubMed:10772806, PubMed:15314147), Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop (PubMed:21408209), Regulates vulval precursor cell (VPC) differentiation, in concert with homeobox protein lin-39 (PubMed:15314147), Involved in promoting embryogenesis, in concert with homeobox protein nob-1 (PubMed:15314147), May play a role in modulation of lifespan and immunity (PubMed:29748542)

Belongs to the nuclear hormone receptor family


This is Probable replication factor A 73 kDa subunit protein, from Caenorhabditis elegans, contains 655 amino acids, has 1 C4-type Zinc finger.

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress, It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism, Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage

Belongs to the replication factor A protein 1 family


This is Vacuolar protein sorting-associated protein 41 homolog protein, from Caenorhabditis elegans, contains 901 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301), Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556), The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity), Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine (PubMed:24501423), May mediate the tethering of autophagosomes with lysosomes (PubMed:24374177), Has a role in the negative regulation of apoptosis (PubMed:15837622), Required for uptake of exogenous dsRNA which is used in experimental RNA silencing (PubMed:16862146)


This is Zinc finger SWIM domain-containing protein 7 protein, from Human, contains 140 amino acids, has 1 SWIM-type Zinc finger.

SWIM-type

Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents, Required for meiotic progression, hence for fertility (PubMed:32719396, PubMed:33713115, PubMed:34402903)


This is Gag polyprotein protein, from SIV-cpz, contains 511 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Gag polyprotein protein, from SIV-cpz, contains 499 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Tripartite motif-containing protein 5 protein, from Cotton-top tamarin, contains 494 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2


This is Tripartite motif-containing protein 5 protein, from Siamang, contains 494 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Tripartite motif-containing protein 5 protein, from Northern white-cheeked gibbon, contains 494 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Tripartite motif-containing protein 5 protein, from Pygmy chimpanzee, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is CMRF35-like molecule 9 protein, from Mouse, contains 331 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Receptor which may mediate L-selectin-dependent lymphocyte rollings, Binds SELL in a calcium dependent manner, Binds lymphocyte


This is B-box domain protein 30 protein, from Mouse-ear cress, contains 117 amino acids, has 1 B box-type; atypical Zinc finger.

B box-type; atypical

Developmental regulator acting by forming heterodimeric complexes, that sequester CO and CO-like (COL) proteins into non-functional complexes, Engages CO and the transcriptional repressor TPL in a tripartite complex, Involved in the CO-mediated long-day flowering-promotion pathway


This is Speckle targeted PIP5K1A-regulated poly(A) polymerase protein, from Bovine, contains 871 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs, Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1, In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs, In addition to adenylyltransferase activity, also has uridylyltransferase activity, However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase, Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA, Not involved in replication-dependent histone mRNA degradation

Belongs to the DNA polymerase type-B-like family


This is GATA-type transcription factor sre protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 587 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence elements of target promoters in a zinc-dependent manner (PubMed:9790585, PubMed:10194352, PubMed:12484767), Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity) (PubMed:10194352), Represses the synthesis of siderophores in high iron conditions (PubMed:9790585)


This is LON peptidase N-terminal domain and RING finger protein 2 protein, from Human, contains 754 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Vitamin D3 receptor B protein, from Zebrafish, contains 422 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells, Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR, The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes, Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association, Plays a central role in calcium homeostasis


This is E3 ubiquitin-protein ligase RNF138 protein, from African clawed frog, contains 222 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger, has 2 C2H2-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination, Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (By similarity), Together with nlk,2, involved in the ubiquitination and degradation of TCF/LEF, Also exhibits auto-ubiquitination activity in combination with ube2k, May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285)


This is Fanconi-associated nuclease 1 protein, from Zebrafish, contains 988 amino acids, has 1 UBZ4-type Zinc finger.

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2, Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates, Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions, Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL, Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap, Also has endonuclease activity toward 5'-flaps


This is DNA (cytosine-5)-methyltransferase 3-like protein, from Rat, contains 422 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context, Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain, Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (By similarity), Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (By similarity), Plays a key role in embryonic stem cells and germ cells, In germ cells, required for the methylation of imprinted loci together with DNMT3A, In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization, Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation, While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes, Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes, Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity)


This is DNA (cytosine-5)-methyltransferase 3A protein, from Rat, contains 908 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development, DNA methylation is coordinated with methylation of histones, It modifies DNA in a non-processive manner and also methylates non-CpG sites, May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1, Plays a role in paternal and maternal imprinting, Required for methylation of most imprinted loci in germ cells, Acts as a transcriptional corepressor for ZBTB18, Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites, Can actively repress transcription through the recruitment of HDAC activity (By similarity), Also has weak auto-methylation activity on Cys-706 in absence of DNA (By similarity)

Belongs to the class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family


This is E3 ubiquitin-protein ligase brl1 protein, from Fission yeast, contains 692 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation


This is E3 ubiquitin-protein ligase TRIM71 protein, from Chicken, contains 876 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance, Binds to miRNAs and participates in post-transcriptional repression of transcripts, Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development


This is E3 ubiquitin-protein ligase TRIM71 protein, from Mouse, contains 855 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (PubMed:19898466), Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A, Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression (PubMed:22735451), In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361), Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (PubMed:22735451), Specific regulator of miRNA biogenesis, miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity)


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 3 protein, from Bovine, contains 628 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Promotes neurite outgrowth in hippocampal neurons (By similarity)


This is GATA-type zinc finger protein 1 protein, from Mouse, contains 266 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional regulator that plays a key role in germ cell development (PubMed:16982049, PubMed:21123517, PubMed:32054698), Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry (PubMed:32054698), Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells (PubMed:32054698), Regulates expression of STRA8, a central downstream effector for the meiotic program (PubMed:32054698), Acts independently of retinoic acid (RA) (PubMed:32054698), In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase (PubMed:32054698)


This is Cell adhesion molecule 4 protein, from Rat, contains 388 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Involved in the cell-cell adhesion, Has calcium- and magnesium-independent cell-cell adhesion activity, May have tumor-suppressor activity (By similarity)


This is Cell adhesion molecule 2 protein, from Rat, contains 435 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation, Important for synapse organization, providing regulated trans-synaptic adhesion, Preferentially binds to oligodendrocytes (By similarity)


This is Tripartite motif-containing protein 72 protein, from Mouse, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites, Specifically binds phosphatidylserine, Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site, This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation, Probably acts upstream of the Ca(2+)-dependent membrane resealing process, Required for transport of DYSF to sites of cell injury during repair patch formation, Regulates membrane budding and exocytosis, May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles


This is E3 ubiquitin-protein ligase TRIM39 protein, from Chimpanzee, contains 518 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase (By similarity), May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity), Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity), Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity)


This is Anaphase-promoting complex subunit 11 protein, from Caenorhabditis elegans, contains 135 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581), The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581), Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis (PubMed:11861581), In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity (PubMed:15466891)


This is C-terminal-binding protein 1 protein, from Caenorhabditis elegans, contains 727 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Binds DNA and represses gene expression, Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family


This is Zinc finger protein tra-4 protein, from Caenorhabditis elegans, contains 543 amino acids, has 7 C2H2-type Zinc finger.

Probable transcription factor (PubMed:17011494), Promotes normal hermaphrodite (XX) development, in concert with histone deacetylase hda-1 and nasp-1, perhaps as components of a complex (PubMed:17011494), May cooperate with transcription factor tra-1 to repress male-specific genes in hermaphrodites (PubMed:17011494), Synthetic multivulva (synMuv) class B protein, required to repress the induction of vulval development by let-60 Ras signaling (PubMed:17011494)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase hrd-1 protein, from Caenorhabditis elegans, contains 610 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation, Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins, Also promotes the degradation of normal but naturally short-lived proteins, Protects cells from ER stress-induced apoptosis, Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation


This is BRCA1-associated RING domain protein 1 protein, from Caenorhabditis elegans, contains 702 amino acids, has 1 RING-type Zinc finger.

RING-type

Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity (PubMed:16628214), When bound to chromatin, the brc-1-brd-1 heterodimer within the CeBCD complex is inactive during normal conditions, but in response to DNA damage, the brc-1-brd-1 heterodimer associates with other proteins such as the recombinase rad-51 or the E2-ubiquitin-conjugating enzyme let-70, which activate the CeBCD complex as an E3-ubiquitin ligase (PubMed:16628214), Moreover, association between the brc-1-brd-1 heterodimer and rad-51 and let-70, probably requires DNA checkpoint proteins such as atl-1 and mre-11 in order to induce ubiquitination at DNA damage sites (PubMed:16628214), To this end, the brc-1-brd-1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:14711411, PubMed:30383754), Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by ionizing radiation for example (PubMed:14711411, PubMed:30383754), In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand break repair to ensure sister chromatid recombination and aid chromosome stability (PubMed:14711411)


This is MOG interacting and ectopic P-granules protein 1 protein, from Caenorhabditis elegans, contains 870 amino acids, has 6 C2H2-type Zinc finger, has 1 CCHC-type Zinc finger.

CCHC-type

Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate, Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch, Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR


This is Zinc finger protein egl-43 protein, from Caenorhabditis elegans, contains 543 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 3; atypical

Dispensable for anchor cell (AC) invasion and for preventing AC proliferation


This is DNA-dependent metalloprotease dvc-1 protein, from Caenorhabditis elegans, contains 368 amino acids, has 1 UBZ4-type Zinc finger.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:27871365), DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:27871365), Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (PubMed:27871365), Regulator of UV-induced DNA damage response: required to protect genome stability during DNA replication, possibly via recruitment of vcp/p97 (cdc-48,1 or cdc-48,2) recruitment (PubMed:23042605)


This is Ras association domain-containing protein 1 homolog protein, from Caenorhabditis elegans, contains 615 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in embryonic morphogenesis (PubMed:23103556), Plays a role in the organization of apical filamentous actin in epithelial cells of the developing embryo (PubMed:23103556), May play a role in let-60-mediated vulval development (PubMed:23103556), May induce nuclear condensation (PubMed:23103556), Positively regulates the oxidative stress response, and this may be in association with the small GTPase rab-39 (PubMed:23294242), Not required for muscle integrity (PubMed:23103556)


This is CCCH-type zinc finger protein oma-2 protein, from Caenorhabditis elegans, contains 393 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos (PubMed:18417623), Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development (PubMed:11702779, PubMed:12296824, PubMed:12781695, PubMed:16289132, PubMed:16611242, PubMed:18854162, PubMed:18417623, PubMed:19786575, PubMed:20826530, PubMed:25261697), Also, together with oma-1, is involved in P-granule distribution during embryonic development (PubMed:16611242)


This is RING-box protein 1 protein, from Caenorhabditis elegans, contains 110 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity), Essential for meiosis, mitotic chromosomal condensation and cytokinesis, Involved in histone H3 phosphorylation


This is Protein deltex protein, from Fruit fly, contains 738 amino acids, has 1 RING-type Zinc finger.

RING-type

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context, Mediates the antineural activity of Notch, May function as a ubiquitin ligase protein in the Notch pathway


This is Nuclear hormone receptor HR78 protein, from Fruit fly, contains 601 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds to direct repeats of the sequence 5'-AGGTCA-3', Inhibits the ecdysone response, Plays an essential role in regulating molting of the tracheal cuticle during larval development

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Nuclear hormone receptor HR96 protein, from Fruit fly, contains 723 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds selectively to the HSP27 20E response element

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Protein abrupt protein, from Fruit fly, contains 904 amino acids, has 2 C2H2-type Zinc finger.

Expression is vital for development; may be involved in transcriptional regulation, In embryos, muscle specific expression is required for segmental nerve b (SNb) motoneuron target recognition within ventral longitudinal muscles, Has a role in establishing and maintaining embryonic muscle attachments, adult sensory cell formation (macrochaetae) and morphogenesis of adult appendages (legs, antenna aristae and male external genitalia), Has a role in the morphogenesis of the class I dendritic neurons: selective expression of ab in class I da neurons plays a pivotal role in forming dendritic arbors, which are characteristic of the class I cells, The development of more complex arbors of class II-IV neurons depends on the absence of ab


This is Deformed epidermal autoregulatory factor 1 protein, from Fruit fly, contains 576 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcription factor that binds the homeotic Deformed (Dfd) response element, High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences, May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein, Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd


This is Broad-complex core protein isoform 6 protein, from Fruit fly, contains 880 amino acids, has 2 C2H2-type Zinc finger.

Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis


This is Transcription factor btd protein, from Fruit fly, contains 644 amino acids, has 3 C2H2-type Zinc finger.

Required for the development of the antennal, intercalary and mandibular segments of the head


This is Death-associated inhibitor of apoptosis 1 protein, from Fruit fly, contains 438 amino acids, has 1 RING-type Zinc finger.

RING-type

Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity, Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1, Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice, Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation, Plays an important role in cell motility, Overexpression suppresses rpr and hid-dependent cell death in the eye, Interaction of Diap1 with Dronc is required to suppress Dronc-mediated cell death through Diap1-mediated ubiquitination of Dronc, Acts as a positive regulator of Wnt signaling


This is Death-associated inhibitor of apoptosis 2 protein, from Fruit fly, contains 498 amino acids, has 1 RING-type Zinc finger.

RING-type

Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria (PubMed:16894030, PubMed:17068333), Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides (PubMed:17068333, PubMed:24374974), Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides (PubMed:22549468), Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice (PubMed:18166655), Suppresses rpr and hid-dependent cell death in the eye (PubMed:8548811), However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway (PubMed:17068333), Plays a role in regulating the expression of ion channels (PubMed:24374974)


This is Semaphorin-2A protein, from Fruit fly, contains 724 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ligand for transmembrane receptor PlexB (PubMed:16672342), Plays a role in growth cone guidance (PubMed:8269517, PubMed:27618755), Required for both proper adult behavior and survival (PubMed:8269517), Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors (PubMed:8269517), During embryogenesis, plays an important role in correct salivary gland positioning (PubMed:27618755)


This is Lachesin protein, from Fruit fly, contains 359 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier, Functions as a homophilic cell-adhesion molecule, May play a role in early neuronal differentiation and axon outgrowth


This is Zinc finger protein Noc protein, from Fruit fly, contains 537 amino acids, has 1 C2H2-type Zinc finger.

May negatively regulate Notch-induced cell proliferation in the eye-head primordium, Required for development of the supraesophageal ganglion and ocelli, May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation, Plays a role in tracheal development


This is Replication protein A 70 kDa DNA-binding subunit protein, from Fruit fly, contains 603 amino acids, has 1 C4-type Zinc finger.

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress, It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism, Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage


This is Protein neuralized protein, from Fruit fly, contains 747 amino acids, has 1 RING-type Zinc finger.

RING-type

Involved in neurogenesis, Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate


This is Netrin receptor unc-5 protein, from Caenorhabditis elegans, contains 947 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756), Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756, PubMed:9473333), Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756, PubMed:9473333), Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279, PubMed:17716643)


This is Fibroblast growth factor receptor protein, from Purple sea urchin, contains 972 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for basic fibroblast growth factor

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Orphan steroid hormone receptor 2 protein, from Purple sea urchin, contains 583 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds to the hormone response element in the upstream promoter region of the CYIIIB gene in vitro, Both isoform 1 and isoform 2 bind DNA


This is Protein tumorous imaginal discs, mitochondrial protein, from Fruit fly, contains 520 amino acids, has 1 CR-type Zinc finger.

CR-type

May act as a tumor suppressor in larval imaginal disks


This is RNA-binding protein cabeza protein, from Fruit fly, contains 399 amino acids, has 1 RanBP2-type Zinc finger.

May participate in a function common to the expression of most genes transcribed by RNA polymerase II


This is Transcription factor lin-26 protein, from Caenorhabditis elegans, contains 490 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Probable transcription factor (PubMed:7956818, PubMed:24885717), Required to specify the fates of hypodermal and neuron-associated support cells (PubMed:7956818), Functions during vulval development, playing a role in vulval precursor cell fate specification (PubMed:11063687, PubMed:24885717), Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717)


This is Gag polyprotein protein, from XMRV, contains 536 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome (By similarity), Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome (By similarity), This binding is dependent on genome dimerization (By similarity), Acts as a nucleic acid chaperone which is involved in rearrangement of nucleic acid secondary structures during gRNA retrotranscription (By similarity)


This is Mast/stem cell growth factor receptor Kit protein, from Goat, contains 978 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis, In response to KITLG/SCF binding, KIT can activate several signaling pathways, Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL, Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B, Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Mast/stem cell growth factor receptor Kit protein, from Cat, contains 978 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Interleukin-12 subunit beta protein, from Pig, contains 324 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity, IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues, IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines, IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity)


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Pig, contains 257 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:31323052), Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC), Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity), Mediates IgG effector functions on natural killer (NK) cells, Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity), Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes, Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821)


This is Estrogen receptor protein, from Pig, contains 595 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP, Can activate the transcriptional activity of TFF1, Also mediates membrane-initiated estrogen signaling involving various kinase cascades,Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity)

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is MHC class I polypeptide-related sequence B protein, from Human, contains 383 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Seems to have no role in antigen presentation, Acts as a stress-induced self-antigen that is recognized by gamma delta T cells, Ligand for the KLRK1/NKG2D receptor, Binding to KLRK1 leads to cell lysis

Belongs to the MHC class I family, MIC subfamily


This is MHC class I polypeptide-related sequence A protein, from Human, contains 383 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Seems to have no role in antigen presentation, Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells, Ligand for the KLRK1/NKG2D receptor, Binding to KLRK1 leads to cell lysis


This is Interference hedgehog protein, from Fruit fly, contains 903 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc)

Belongs to the immunoglobulin superfamily, IHOG family


This is Early growth response protein 1 protein, from Bovine, contains 540 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Transcriptional regulator, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity), Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity), Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia, Plays a role in the regulation of cell survival, proliferation and cell death, Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation, Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy, Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia, Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity), Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription, Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity)

Belongs to the EGR C2H2-type zinc-finger protein family


This is RE1-silencing transcription factor protein, from Zebrafish, contains 855 amino acids, has 9 C2H2-type Zinc finger.

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells


CCHC-type


This is E3 ubiquitin-protein ligase RNF8 protein, from Bovine, contains 487 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites, Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF), Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites, Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases, For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains, Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5, Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (By similarity), Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta, In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (By similarity), In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation, Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase, Required in the testis, where it plays a role in the replacement of histones during spermatogenesis, At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis, Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis, May play a role in the regulation of RXRA-mediated transcriptional activity, Not involved in RXRA ubiquitination by UBE2E2 (By similarity)


This is mRNA export factor ICP27 homolog protein, from HHV-8, contains 455 amino acids, has 1 CHC2-type Zinc finger.

Early protein that promotes the accumulation and nuclear export of viral intronless RNA transcripts by interacting with mRNAs and cellular export proteins, Probably acts as a viral splicing factor that regulates viral RNA splicing, Functions as a multifunctional regulator of the expression of viral lytic genes

Belongs to the HHV-1 ICP27 protein family


This is Mast/stem cell growth factor receptor Kit protein, from Pig, contains 972 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is RING finger protein 151 protein, from Human, contains 245 amino acids, has 1 RING-type Zinc finger, has 1 TRAF-type Zinc finger.

RING-type

TRAF-type

May be involved in acrosome formation of spermatids


This is Transcription initiation factor IIB protein, from Bovine, contains 316 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II), Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA, Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex, Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle, Associates with chromatin to core promoter-specific regions, Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element, Modulates transcription start site selection, Exhibits also autoacetyltransferase activity that contributes to the activated transcription


This is Ubiquitin carboxyl-terminal hydrolase 16 protein, from Rat, contains 826 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator, Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis, In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes, Regulates Hox gene expression via histone H2A deubiquitination, Prefers nucleosomal substrates, Does not deubiquitinate histone H2B, Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit

Belongs to the peptidase C19 family, USP16 subfamily


This is Probable E3 ubiquitin-protein ligase IRF2BPL protein, from Rhesus macaque, contains 794 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins, Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway, Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity), Also acts as a transcriptional regulator of genes controlling female reproductive function, May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)


This is E3 ubiquitin-protein ligase RNF146 protein, from Crab-eating macaque, contains 360 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex, Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2, Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation, Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48', May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location, Neuroprotective protein (By similarity), Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity), Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity), Does not affect PARP1 activation, Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity), Promotes cell survival after gamma-irradiation, Facilitates DNA repair (By similarity)


This is E3 ubiquitin-protein ligase TRIM71 protein, from Human, contains 868 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable), Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity), In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361), Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression, Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity), Specific regulator of miRNA biogenesis, Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233)


This is Zinc finger protein ZXDC protein, from Human, contains 858 amino acids, has 10 C2H2-type Zinc finger.

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes


This is DNA replication licensing factor MCM2 protein, from Rice, contains 961 amino acids, has 1 C4-type Zinc finger.

Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells, Can complement the fission yeast mcm2 mutant


This is High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor protein, from Mouse, contains 535 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Functions as a receptor for the Fc fragment of IgA and IgM, Binds IgA and IgM with high affinity and mediates their endocytosis, May function in the immune response to microbes mediated by IgA and IgM


This is Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog protein, from Mouse, contains 832 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity), Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (By similarity), Involved in the induction of T helper 17 cells (Th17) differentiation (By similarity), Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (PubMed:25282160), Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation, May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (By similarity)


This is Zinc finger protein ZPR1 protein, from Bovine, contains 459 amino acids, has 2 C4-type Zinc finger.

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus, Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies, Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons, Plays a role in the splicing of cellular pre-mRNAs, May be involved in H(2)O(2)-induced neuronal cell death (By similarity)


This is Histone acetyltransferase ESA1 protein, from Yellow koji mold, contains 506 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


This is Zinc finger transcription factor YY1 protein, from Mouse-ear cress, contains 387 amino acids, has 5 C2H2-type Zinc finger.

Dual-function transcription factor with both repression and activation activities, Binds to 5'-CCATATT-3' motif in target gene promoters (e,g, ABR1) (PubMed:26961720), Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367), Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e,g, salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720), Regulates plant immunity, especially during necrotrophic fungal infection (e,g, B,cinerea) (PubMed:24451981), Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway, Represses ABA- and salt-responsive genes expression (PubMed:26961720)


This is E3 ubiquitin-protein ligase RNF19A protein, from Pig, contains 838 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR

Belongs to the RBR family, RNF19 subfamily


This is Carcinoembryonic antigen-related cell adhesion molecule 16 protein, from Human, contains 425 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane

Belongs to the immunoglobulin superfamily, CEA family


This is Leucine-rich repeat and fibronectin type III domain-containing protein 1 protein, from Mouse, contains 766 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Promotes neurite outgrowth in hippocampal neurons, Involved in the regulation and maintenance of excitatory synapses, Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1


This is Junctional adhesion molecule A protein, from Cat, contains 298 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

(Microbial infection) In case of orthoreovirus infection, serves as receptor for the virus

Belongs to the immunoglobulin superfamily


This is Tripartite motif-containing protein 5 protein, from Western hoolock gibbon, contains 494 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2


This is Tripartite motif-containing protein 5 protein, from Bornean orangutan, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Tripartite motif-containing protein 5 protein, from Pig-tailed macaque, contains 495 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Tripartite motif-containing protein 5 protein, from Assam macaque, contains 497 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is HLA class II histocompatibility antigen, DR beta 5 chain protein, from Human, contains 266 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells, The peptide binding cleft accommodates peptides of 10-30 residues, The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases, Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous, As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components, Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments, In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract, To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer, Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide), The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released, HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound, The MHC II molecule bound to a peptide is then transported to the cell membrane surface, In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO, Primary dendritic cells (DCs) also to express HLA-DO, Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading


This is Hereditary hemochromatosis protein protein, from Human, contains 348 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin


This is Polycomb complex protein BMI-1 protein, from Bovine, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A, In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2


This is E3 SUMO-protein ligase NSE2 protein, from Bovine, contains 248 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination, Is not be required for the stability of the complex, The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks, Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2, Required for recruitment of telomeres to PML nuclear bodies, Required for sister chromatid cohesion during prometaphase and mitotic progression


This is E3 ubiquitin-protein ligase TRIM13 protein, from Bovine, contains 407 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD), This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins, Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, Regulates ER stress-induced autophagy, and may act as a tumor suppressor, Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway, Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation, Participates as well in T-cell receptor-mediated NF-kappa-B activation, In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B


This is E3 ubiquitin-protein ligase MARCHF2 protein, from Bovine, contains 245 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity), Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity), Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity), Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (By similarity), May be involved in endosomal trafficking through interaction with STX6


This is Zinc finger protein 750 protein, from Human, contains 723 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Transcription factor involved in epidermis differentiation, Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes, Specifically binds to the promoter of KLF4 and promotes its expression


This is E3 ubiquitin-protein ligase BRE1-like 2 protein, from Rice, contains 844 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1, H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is a prerequisite for H3 Lys-4 methylation (H3K4me), It thereby plays a central role in histone code and gene regulation (PubMed:26143250, PubMed:26934377), H2B monoubiquitination, mediated by HUB2, modulates transcriptional regulation of anther development, likely by promoting histone H3K4 dimethylation (H3K4me2) in the chromatin of the key tapetum degradation-related genes C4, CP1 and UDT1 (PubMed:26143250), H2B monoubiquitination, mediated by HUB2, modulates transcriptional regulation of genes associated with flowering time and plant yield (PubMed:26934377)


This is Transcriptional regulator SUPERMAN protein, from Mouse-ear cress, contains 204 amino acids, has 1 C2H2-type Zinc finger.

Probable transcriptional regulator considered as cadastral protein that acts indirectly to prevent the B class homeotic proteins APETALA3 and perhaps PISTILLATA from acting in the gynoecial whorl, Principal function is to balance cell proliferation in the third and fourth whorls of developing flowers thereby maintaining the boundary between stamens and carpels, May fulfill this role by repressing genes implicated in cell division, Plays equally a role in the determinacy of the floral meristem, Is also required for normal ovule development


This is Cold shock domain-containing protein 4 protein, from Mouse-ear cress, contains 201 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Chaperone that binds to and unwinds RNA and both single-stranded DNA and double-stranded DNA (ssDNA and dsDNA DNA) (By similarity), Regulates the flowering transition and flower and seed development, particularly at late stages of embryo development, through regulation of gene expression (including MEA, FIS2, AP1, CAL, AG and SHP2)

Belongs to the cold shock protein (CSP) family


This is E3 ubiquitin-protein ligase TRIM63 protein, from Mouse, contains 350 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase, Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH, Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids, Inhibits de novo skeletal muscle protein synthesis under amino acid starvation, Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins, May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway, May regulate the organization of myofibrils through TTN in muscle cells


This is Zinc finger protein CONSTANS protein, from Mouse-ear cress, contains 373 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Transcription factor that acts in the long day flowering pathway and may mediate between the circadian clock and the control of flowering, Plays a role in the regulation of flowering time by acting on 'SUPPRESSOR OF OVEREXPRESSION OF CO1', 'TERMINAL FLOWER 1' and 'FLOWERING LOCUS T', Also regulates P5CS2 and ACS10 (involved in proline and ethylene biosynthesis, respectively), Regulates the expression of NAKR1 by binding to the 5'-TGTG(N2-3)ATG-3' motif (PubMed:27255839)


This is Dof zinc finger protein DOF3.4 protein, from Mouse-ear cress, contains 253 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence, Enhances the DNA binding of OBF transcription factors to OCS elements


This is Zinc finger protein 5 protein, from Mouse-ear cress, contains 211 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin (GA), Acts upstream of GIS, GIS2, ZFP8 and the trichome initiation regulators GL1 and GL3 (PubMed:21803862, PubMed:22301962), Binds the promoter region of ZFP8, which may be a direct target of ZPF5 (PubMed:21803862), Is not involved in the regulation of trichome branching (PubMed:22301962), Modulates root hair initiation and elongation in response to cytokinin and ethylene signals by directly promoting expression of the CAPRICE (CPC) gene (PubMed:22762888)


This is Zinc finger protein 6 protein, from Mouse-ear cress, contains 197 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin, Acts upstream of GIS, GIS2, ZFP8, ZFP5 and the trichome initiation regulators GL1 and GL3 (PubMed:23506479), Acts as negative regulator of abscisic acid (ABA) signaling during germination and early seedling development (PubMed:24808098)


This is Zinc finger CCCH domain-containing protein 7 protein, from Mouse-ear cress, contains 470 amino acids, has 5 C3H1-type Zinc finger.

Possesses RNA-binding and ribonuclease activities in vitro


This is Zinc finger protein 829 protein, from Human, contains 432 amino acids, has 9 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

May be involved in transcriptional regulation


This is Polycomb group RING finger protein 3 protein, from Human, contains 242 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332), Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity)


This is Zinc finger protein 792 protein, from Human, contains 632 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate


This is Trem-like transcript 4 protein protein, from Mouse, contains 263 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages (PubMed:25848864), Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes (PubMed:25848864), Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production (PubMed:25848864), Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus (PubMed:25848864), Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs) (PubMed:22210914, PubMed:19155473, PubMed:25848864), Does not bind nucleic acids (PubMed:25848864), May participate in antigen presentation (PubMed:22210914)


This is E3 ubiquitin-protein transferase MAEA protein, from Bovine, contains 434 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, MAEA is required for normal cell proliferation, The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity), Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity), Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity), Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis, Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity), May contribute to nuclear architecture and cells division events (By similarity)


This is Zinc finger protein SNAI2 protein, from Bovine, contains 268 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; atypical Zinc finger.

C2H2-type 5; atypical

Transcriptional repressor that modulates both activator-dependent and basal transcription, Involved in the generation and migration of neural crest cells, Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells, Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells, In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription, Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes, Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes, Represses E-Cadherin/CDH1 transcription via E-box elements, Involved in osteoblast maturation, Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts, Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts, Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity)

Belongs to the snail C2H2-type zinc-finger protein family


This is Zinc finger protein 830 protein, from Rat, contains 370 amino acids, has 1 C2H2-type Zinc finger.

May play a role in pre-mRNA splicing as component of the spliceosome (By similarity), Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity, During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation, Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells, During the embryo preimplantation, controls different aspects of M phase, During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity)


This is Speckle targeted PIP5K1A-regulated poly(A) polymerase protein, from Rat, contains 866 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs, Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1, In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs, In addition to adenylyltransferase activity, also has uridylyltransferase activity, However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase, Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA, Not involved in replication-dependent histone mRNA degradation

Belongs to the DNA polymerase type-B-like family


This is RNA-binding protein 4 protein, from Bovine, contains 362 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation, Modulates alternative 5'-splice site and exon selection, Acts as a muscle cell differentiation-promoting factor, Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation, Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin, Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs, Required for the translational activation of PER1 mRNA in response to circadian clock, Binds directly to the 3'-UTR of the PER1 mRNA, Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation, Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress, Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions, Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs, Associates with miRNAs during muscle cell differentiation, Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity)


This is Zinc finger and SCAN domain-containing protein 23 protein, from Human, contains 389 amino acids, has 5 C2H2-type Zinc finger.

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Platelet endothelial cell adhesion molecule protein, from Rat, contains 678 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions, Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes, Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions, Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils, Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal, Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes, Modulates bradykinin receptor BDKRB2 activation, Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells, Induces susceptibility to atherosclerosis


This is Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 protein, from Human, contains 679 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (By similarity), Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:28334377), Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity), Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (By similarity), May also have a role in cone synapse formation (By similarity), Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (PubMed:22673519), Could be a regulator of the FGFRs (PubMed:22673519)


This is Transcription factor Sp6 protein, from Human, contains 376 amino acids, has 3 C2H2-type Zinc finger.

Promotes cell proliferation (By similarity), Plays a role in tooth germ growth (By similarity), Plays a role in the control of enamel mineralization, Binds the AMBN promoter (PubMed:32167558)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Bile acid receptor protein, from Bovine, contains 482 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA), Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation, Also regulates lipid and glucose homeostasis and is involved innate immune response, The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands, It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity, In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs), Activates transcription of the repressor MAFG (involved in regulation of BA synthesis), Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine), Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine), In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression, The function also involves the coordinated induction of hepatic KLB/beta-klotho expression, Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA, Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly), Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance), Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element, Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase), Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes, Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3), Modulates glucose-stimulated insulin secretion and is involved in insulin resistance, Involved in intestinal innate immunity, Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier, Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells, Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2, Involved in the TLR9-mediated protective mechanism in intestinal inflammation, Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Transcriptional adapter 2-alpha protein, from Bovine, contains 443 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4, Required for the function of some acidic activation domains, which activate transcription from a distant site, Binds double-stranded DNA, Binds dinucleosomes, probably at the linker region between neighboring nucleosomes, Plays a role in chromatin remodeling, May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity, May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage


This is Protein odd-skipped-related 2 protein, from Bovine, contains 276 amino acids, has 3 C2H2-type Zinc finger.

Belongs to the Odd C2H2-type zinc-finger protein family


This is Allergin-1 protein, from Mouse, contains 246 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells, Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction


This is E3 ubiquitin ligase Rnf157 protein, from Mouse, contains 685 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469), Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469), May act as a scaffold molecule to regulate this process (PubMed:25342469), Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity)


This is Zinc finger CCCH domain-containing protein 15 protein, from Mouse, contains 426 amino acids, has 2 C3H1-type Zinc finger.

Protects DRG1 from proteolytic degradation (PubMed:15676025), Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity)