This is Transcriptional regulator MET31 protein, from Baker's yeast, contains 177 amino acids, has 1 C2H2-type Zinc finger.

Auxiliary transcriptional regulator of sulfur amino acid metabolism, Involved in the transcriptional activation of MET28


This is Transcriptional regulator NRG1 protein, from Baker's yeast, contains 231 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional repressor involved in regulation of glucose repression, Binds to UAS-1 in the STA1 promoter


This is Fibroblast growth factor receptor 4 protein, from Mouse, contains 799 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis, Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19, Phosphorylates PLCG1 and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4, Plays a role in postnatal lung development, May be involved in the development of skeletal muscle cell lineages

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is MYND-type zinc finger protein MUB1 protein, from Baker's yeast, contains 620 amino acids, has 1 MYND-type; degenerate Zinc finger.

MYND-type; degenerate

Involved in the determination of the onset of polarized growth, Required for the ubiquitin-dependent degradation of RPN4, Cooperates with UBR2 to transfer ubiquitin from RAD6 to RPN4


This is Peroxisome proliferator-activated receptor delta protein, from Human, contains 441 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826), Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid, Once activated by a ligand, the receptor binds to promoter elements of target genes, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the acyl-CoA oxidase gene, Decreases expression of NPC1L1 once activated by a ligand

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is DNA-binding protein Ikaros protein, from Mouse, contains 517 amino acids, has 6 C2H2-type Zinc finger.

Transcription regulator of hematopoietic cell differentiation, Binds gamma-satellite DNA, Binds with higher affinity to gamma satellite A, Plays a role in the development of lymphocytes, B- and T-cells, Binds and activates the enhancer (delta-A element) of the CD3-delta gene, Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation, Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes, Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes, Increases normal apoptosis in adult erythroid cells (By similarity), Confers early temporal competence to retinal progenitor cells (RPCs), Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is RNA polymerase II transcription factor B subunit 3 protein, from Baker's yeast, contains 321 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA, TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro


This is NT-3 growth factor receptor protein, from Rat, contains 864 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in nervous system and probably heart development, Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity), NTRK3 isoforms containing insertions within the kinase domain can autophosphorylate in response to NTF3/neurotrophin-3, but cannot mediate downstream phenotypic responses (PubMed:8494647, PubMed:8494648)

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is Fibroblast growth factor receptor 2 protein, from African clawed frog, contains 813 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development, Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development, Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development, Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts, Phosphorylates PLCG1, FRS2 and PAK4, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation, Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling, Over-expressed FGFR2 promotes activation of STAT1 (By similarity)


This is Vacuolar protein sorting-associated protein 71 protein, from Baker's yeast, contains 280 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Participates in the catalytic exchange of histone H2A for the H2A variant HZT1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes, Indirectly involved in vacuolar protein sorting


This is Tyrosine-protein kinase ITK/TSK protein, from Mouse, contains 625 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response, Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells, When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK, Phosphorylation leads to ITK autophosphorylation and full activation, Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates, In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty, Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2, Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation, Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (PubMed:23562159), Phosphorylates TBX21 at 'Tyr-525' and mediates its interaction with GATA3 (PubMed:15662016)

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Probable diacylglycerol kinase 3 protein, from Caenorhabditis elegans, contains 795 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Involved in AFD-neuron mediated thermotaxis, Regulates behavior to environmental temperature, Thought to have a role in olfactory adaptation by affecting diacylglycerol levels

Belongs to the eukaryotic diacylglycerol kinase family


This is Transcriptional activator/repressor GIS1 protein, from Baker's yeast, contains 894 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Transcription factor involved in the regulation of gene expression upon nutrient starvation, Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region, Can act as a transcriptional activator (e,g, of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e,g, of pyrophosphate phosphatase DPP1), GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1


This is Zinc finger protein 85 protein, from Human, contains 595 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger, has 1 C2H2-type 11; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 11; degenerate

Belongs to the krueppel C2H2-type zinc-finger protein family


This is DNA polymerase eta protein, from Baker's yeast, contains 632 amino acids, has 1 UBZ3-type Zinc finger.

DNA polymerase specifically involved in DNA repair, Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls, Plays an important role in the repair of UV-induced pyrimidine dimers, Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions, Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts

Belongs to the DNA polymerase type-Y family


This is E3 SUMO-protein ligase SIZ1 protein, from Baker's yeast, contains 904 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA, May be involved in chromosome maintenance


This is DNA-directed RNA polymerase III subunit RPC10 protein, from Baker's yeast, contains 110 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs, Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is tRNA endonuclease VMS1 protein, from Baker's yeast, contains 632 amino acids, has 1 C2H2-type Zinc finger.

Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:21148305, PubMed:29632312, PubMed:29875445, PubMed:31011209, PubMed:31189955), The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:29875445, PubMed:31011209, PubMed:31189955), VMS1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation by the ERAD pathway and (2) cleaved tRNAs for recycling (PubMed:29632312, PubMed:31011209, PubMed:31189955), Component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD), which is necessary to maintain mitochondrial, cellular, and organismal viability (PubMed:21070972)


This is mRNA export factor ICP27 homolog protein, from HHV-4, contains 479 amino acids, has 1 CHC2-type Zinc finger.

Promotes the nuclear export of a subset of early and late viral mRNAs by interacting with mRNAs and cellular export proteins, Additionally may prevent the establishment of cellular antiviral state, by acting as an alternative splicing factor for cellular RNAs such as STAT1, resulting in a STAT1 mRNA incapable of producing the STAT1alpha isoform

Belongs to the HHV-1 ICP27 protein family


This is Peroxisome assembly protein 12 protein, from Baker's yeast, contains 399 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:9090384, PubMed:19687296, PubMed:22471590, PubMed:11370741, PubMed:35768507), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:35768507), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (PubMed:35768507)


This is Fibroblast growth factor receptor 1 protein, from Rat, contains 822 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration, Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system, Phosphorylates PLCG1, FRS2, GAB1 and SHB, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2, In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription, FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity)


This is Translation termination inhibitor protein ITT1 protein, from Baker's yeast, contains 464 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA


This is General transcription and DNA repair factor IIH subunit SSL1 protein, from Baker's yeast, contains 461 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription


This is Steroidogenic factor 1 protein, from Bovine, contains 461 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator, Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues, Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B, Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes, 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1, The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity, Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3, Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is Protein kinase C theta type protein, from Human, contains 706 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2, In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1, May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway, In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling, Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization, After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR, During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells, May play a minor role in Th1 response, Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways, In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction, May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex, May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway, Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol, Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1, Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Transcriptional regulatory protein RCO1 protein, from Baker's yeast, contains 684 amino acids, has 1 PHD-type Zinc finger, has 1 PHD-type 2; atypical Zinc finger.

PHD-type

PHD-type 2; atypical

Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events


This is Serine/threonine-protein kinase B-raf protein, from Chicken, contains 766 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Protein kinase involved in the activation of the MAP signaling cascade, May play a role in transducing specific signals in neural cells

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is Ubiquitin-protein ligase E3A protein, from Human, contains 875 amino acids, has 1 C4-type; atypical Zinc finger.

C4-type; atypical

(Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses


This is Nuclear hormone receptor FTZ-F1 beta protein, from Fruit fly, contains 808 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Acts as a cofactor to fushi tarazu (ftz), Facilitates the binding of ftz to DNA, Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz, Probably also functions as a receptor for a yet unknown ligand


This is Pro-neuregulin-1, membrane-bound isoform protein, from Chicken, contains 602 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Direct ligand for the ERBB tyrosine kinase receptors, The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses, Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses (PubMed:8453670, PubMed:9491987), Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity)


This is Early growth response protein 4 protein, from Human, contains 589 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator, Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG), Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)

Belongs to the EGR C2H2-type zinc-finger protein family


This is Transcriptional activator VP30 protein, from ZEBOV, contains 288 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical

Multifunctional protein that acts as a viral transcriptional activator (PubMed:12163572, PubMed:27279615), Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription (PubMed:12163572), Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA (PubMed:27315567), Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures, Assists also stop-start transcription at gene junctions to promote transcription of downstream genes (PubMed:18829754), Interaction with NP plays a critical role in transcription initiation by recognizing the RNA stem loop (PubMed:28593988), Interaction with host RBBP6 interferes with NP-VP30 interaction and inhibits viral RNA synthesis, Also acts as a suppressor of RNA silencing by interacting with host DICER1 and TARBP2/TRBP (By similarity)

Belongs to the filoviridae transcriptional activator VP30 family


This is Retinoic acid receptor RXR-alpha protein, from Rat, contains 467 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid that acts as a transcription factor (By similarity), Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (By similarity), The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (By similarity), The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (By similarity), In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity), On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity), Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (By similarity), The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (By similarity), The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:8381967), Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity), Acts as an enhancer of RARA binding to RARE DNA element (By similarity), May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (By similarity), Promotes myelin debris phagocytosis and remyelination by macrophages (By similarity), Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (By similarity), Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Protein kinase C zeta type protein, from Human, contains 592 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance


This is Zinc finger and BTB domain-containing protein 16 protein, from Human, contains 673 amino acids, has 9 C2H2-type Zinc finger.

Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566), Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654), May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues, Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312)


This is Peroxisome biogenesis factor 10 protein, from Baker's yeast, contains 337 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:18644345, PubMed:19687296, PubMed:22471590, PubMed:35768507), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:18644345, PubMed:15283676, PubMed:35768507), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (PubMed:35768507)


This is E3 ubiquitin-protein ligase HEL2 protein, from Baker's yeast, contains 639 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28757607, PubMed:28223409, PubMed:30609991, PubMed:31819057, PubMed:31532761, PubMed:32615089, PubMed:32203490, PubMed:33338396, PubMed:36627279), HEL2 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28757607), Acts as a ribosome collision sensor: specifically recognizes and binds collided ribosome and ubiquitinates the 40S ribosomal proteins RPS20/uS10 and RPS3/uS3 (PubMed:30609991, PubMed:31819057, PubMed:32615089, PubMed:32203490), Catalyzes 'Lys-63'-linked polyubiquitination of RPS20/uS10, promoting recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:30609991, PubMed:31819057, PubMed:36627279), HEL2 also acts as an activator of the No-Go decay (NGD) pathway by mediating polyubiquitination of monoubiquitinated RPS3/uS3 and RPS7/es7: RPS3/uS3 and RPS7/es7 are first monoubiquitinated by MAG2 and MOT2/NOT4, respectively, and HEL2 mediates formation of 'Lys-63'-linked polyubiquitin chains on monoubiquitin, leading to activation of the NGD pathway in a CUE2-mediated endonucleolytic cleavage (PubMed:28943311, PubMed:30893611, PubMed:30609991, PubMed:30718516), Polyubiquitination of RPS3/uS3 also triggers degradation of non-functional 18S rRNA (PubMed:30893611, PubMed:30718516), The RQC pathway and the integrated stress response (ISR) antagonize each other: HEL2 prevents the activation of GCN2, while GCN2 suppresses RQC activation (PubMed:32615089, PubMed:33338396), The RQC pathway functions as a preventive quality control in the secretory pathway: HEL2 binds preferentially to the pre-engaged secretory ribosome-nascent chain complexes and prevents mistargeting of secretory proteins into mitochondria (PubMed:33761353), Independently of its role in RQC, also involved in the polyubiquitination and proteasomal-degradation of excess histone proteins (PubMed:22570702)


This is Protein kinase C delta type protein, from Human, contains 676 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21810427, PubMed:21406692), Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity), Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21810427, PubMed:21406692), In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21810427, PubMed:21406692), In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21810427, PubMed:21406692), In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9, Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway, Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis, Is required for the control of cell cycle progression both at G1/S and G2/M phases, Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity, In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity), Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464), Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2), Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity), Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA, In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500), May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588), In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418), Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372), Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440), The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity), Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462), Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167), Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575)


This is 2-5A-dependent ribonuclease protein, from Human, contains 741 amino acids, has 1 C6-type; atypical Zinc finger.

C6-type; atypical

Endoribonuclease that functions in the interferon (IFN) antiviral response, In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes, RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis, Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances, In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979), Might play a central role in the regulation of mRNA turnover (PubMed:11585831), Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length

Belongs to the protein kinase superfamily


This is U1 small nuclear ribonucleoprotein C protein, from Baker's yeast, contains 231 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region

Belongs to the U1 small nuclear ribonucleoprotein C family


This is 2-5A-dependent ribonuclease protein, from Mouse, contains 735 amino acids, has 1 C6-type Zinc finger.

Endoribonuclease that functions in the interferon (IFN) antiviral response, In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes, RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis, Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances, In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis, Might play a central role in the regulation of mRNA turnover (By similarity), Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length (By similarity)


This is E3 ubiquitin-protein ligase DCST1 protein, from Mouse, contains 732 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Essential sperm cell-surface protein required for sperm-egg fusion and fertilization


This is Dystrophin-related protein 2 protein, from Mouse, contains 957 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells (PubMed:22764250), Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane (PubMed:22764250), Possibly involved in membrane-cytoskeleton interactions of the central nervous system


This is MBT domain-containing protein 1 protein, from Human, contains 628 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:27153538, PubMed:32209463), The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538), MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively) (PubMed:19841675, PubMed:27153538, PubMed:32209463), In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me (PubMed:27153538), Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR) (PubMed:27153538)


This is E3 ubiquitin-protein ligase goliath protein, from Fruit fly, contains 461 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Endosomal E3 ubiquitin-protein ligase that regulates the recycling endosome pathway (PubMed:23353890), May play an indirect role in regulation of gene expression during embryonic mesoderm formation (PubMed:8462875)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Baker's yeast, contains 668 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:12003496, PubMed:14970222), Specifically modifies U47 in cytoplasmic tRNAs (PubMed:14970222), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)

Belongs to the Dus family, Dus3 subfamily


This is mRNA 3'-end-processing protein YTH1 protein, from Baker's yeast, contains 208 amino acids, has 5 C3H1-type Zinc finger.

RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB


This is Tyrosine-protein kinase BTK protein, from Human, contains 659 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921), Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921), After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584), PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584), BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028), Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732), The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732), Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028), Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872), BTK also plays a critical role in transcription regulation (PubMed:19290921), Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921), BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921), Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188), Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831), GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831), ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337), BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337), There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337), BTK has a dual role in the regulation of apoptosis (PubMed:9751072)


This is Nuclear receptor subfamily 4 group A member 2 protein, from Mouse, contains 598 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development, It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is Tyrosine-protein kinase receptor TYRO3 protein, from Human, contains 890 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Peroxisome biogenesis factor 2 protein, from Chinese hamster, contains 304 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane, PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase, PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity), Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70, Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (By similarity)


This is Protein CBFA2T1 protein, from Human, contains 604 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654), Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453), Can repress transactivation mediated by TCF12 (PubMed:16803958), Acts as a negative regulator of adipogenesis (By similarity), The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588)


This is E3 ubiquitin-protein ligase RING1 protein, from Human, contains 406 amino acids, has 1 RING-type Zinc finger.

RING-type

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation, H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility, Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity


This is E3 ubiquitin-protein ligase PIB1 protein, from Baker's yeast, contains 286 amino acids, has 1 FYVE-type Zinc finger, has 1 RING-type; atypical Zinc finger.

FYVE-type

RING-type; atypical

Functions as an E3 ubiquitin-protein ligase, Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate


This is Vacuolar protein-sorting-associated protein 36 protein, from Baker's yeast, contains 566 amino acids, has 1 RanBP2-type 1; degenerate Zinc finger, has 1 RanBP2-type Zinc finger.

RanBP2-type 1; degenerate

Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (PubMed:12194858, PubMed:15469844, PubMed:15329733), The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (PubMed:12194858), The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (PubMed:12194858), Involved in the trafficking of the plasma membrane ATPase (PubMed:12194858), Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (PubMed:15029239)


This is Nuclear receptor subfamily 2 group F member 1-A protein, from Zebrafish, contains 411 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Putative transcription factor that is required in photoreceptor cells precursors during eye development


This is Zinc finger protein 33A protein, from Human, contains 810 amino acids, has 16 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Early growth response protein 3 protein, from Human, contains 387 amino acids, has 3 C2H2-type Zinc finger.

Probable transcription factor involved in muscle spindle development


This is E3 ubiquitin-protein ligase SIAH1B protein, from Mouse, contains 282 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes

Belongs to the SINA (Seven in absentia) family


This is E3 ubiquitin-protein ligase SIAH2 protein, from Mouse, contains 325 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:24809345, PubMed:26070566), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:26070566), Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:26070566), Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia, Promotes monoubiquitination of SNCA (By similarity), Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:26070566), It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:9637679, PubMed:26070566), Has some overlapping function with SIAH1, Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not, Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (By similarity), Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558), Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed:24809345), Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (By similarity)


This is Zinc finger protein Gfi-1 protein, from Rat, contains 423 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor essential for hematopoiesis, Functions in a cell-context and development-specific manner, Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes, Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development, Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development, Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity), Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling, Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA, Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth, Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 promoter region, Implicated in the maintenance of inner ear hair cells (By similarity)


This is Thy-1 membrane glycoprotein protein, from Chicken, contains 160 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain


This is Zinc finger and SCAN domain-containing protein 21 protein, from Mouse, contains 555 amino acids, has 7 C2H2-type Zinc finger.

Strong transcriptional activator (PubMed:1284028), Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (PubMed:27492080)


This is Metal regulatory transcription factor 1 protein, from Mouse, contains 675 amino acids, has 6 C2H2-type Zinc finger.

Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:24529376), Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (By similarity), Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (PubMed:24529376)


This is Raf homolog serine/threonine-protein kinase protein, from Caenorhabditis elegans, contains 813 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Protein kinase that participates in the induction of vulva and has roles in fertility and viability, Acts downstream of the Ras protein let-60 (PubMed:8483497, PubMed:11861555, PubMed:14724126), Required for progression of developing oocytes through the pachytene stage (PubMed:19826475), Plays a role in responses to M,nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855), Positively regulates lifespan upstream of mek-2 and mpk-1 (PubMed:20624915)


This is Pre-mRNA-splicing factor PRP11 protein, from Baker's yeast, contains 266 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for addition of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly


This is mRNA decay activator protein ZFP36L1 protein, from Human, contains 338 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173), Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258), Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868), Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity), Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173), Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity), Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863), Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587), Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173), Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity), May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217), In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity), Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity), Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404), In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157), Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811), Plays a role in vasculogenesis and endocardial development (By similarity), Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009), Plays a role in myoblast cell differentiation (By similarity)


This is Fibroblast growth factor receptor homolog 1 protein, from Fruit fly, contains 729 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be required for patterning of muscle precursor cells, May be essential for generation of mesodermal and endodermal layers, invaginations of various types of cells and CNS formation

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is E3 ubiquitin-protein ligase BRE1 protein, from Baker's yeast, contains 700 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation, It thereby plays a central role in histone code and gene regulation, Also modulates the formation of double-strand breaks during meiosis


This is Sodium channel subunit beta-1 protein, from Human, contains 218 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development, Stimulates neurite outgrowth (PubMed:21994374), Has no regulatory function on the SCN2A sodium channel complex (PubMed:14622265)

Belongs to the sodium channel auxiliary subunit SCN1B (TC 8,A,17) family


This is Natural killer cell receptor 2B4 protein, from Mouse, contains 397 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, Acts as activating natural killer (NK) cell receptor (PubMed:8326140, PubMed:12734329, PubMed:19648922, PubMed:20962259), Activating function implicates association with SH2D1A and FYN, Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL, Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2, Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8326140, PubMed:15169881, PubMed:15998796, PubMed:22683124), Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (PubMed:15905190), Regulation of NK cell activity by adapters Sh2d1b and Sh2d1b2 is reported conflictingly (PubMed:16127454, PubMed:16425036), Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1, At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (By similarity), Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (PubMed:11739483), Inhibits inflammatory responses in dendritic cells (DCs) (PubMed:25643613)


This is Transcription factor COE1 protein, from Mouse, contains 591 amino acids, has 1 C5-type Zinc finger.

Key pioneer transcription factor of B-cell specification and commitment (PubMed:1915300, PubMed:7542362, PubMed:23812095), Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (PubMed:20876732), Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates (PubMed:23812095, PubMed:20451411), For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage (PubMed:23812095, PubMed:20451411), In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (PubMed:32130892)


This is Peroxisome proliferator-activated receptor alpha protein, from Human, contains 468 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Key regulator of lipid metabolism, Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC), Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety, Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the ACOX1 and P450 genes, Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2, May be required for the propagation of clock information to metabolic pathways regulated by PER2

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Non-structural maintenance of chromosomes element 1 protein, from Baker's yeast, contains 336 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks


This is Nuclear receptor subfamily 4 group A member 2 protein, from Rat, contains 598 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development, It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity), May confer liver-specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR


This is Bud site selection protein 20 protein, from Baker's yeast, contains 166 amino acids, has 1 C2H2-type Zinc finger.

Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:23045392), Involved in positioning the proximal bud pole signal (PubMed:11452010)

Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family


This is ERAD-associated E3 ubiquitin-protein ligase HRD1 protein, from Baker's yeast, contains 551 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation, Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD), Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M), In ERAD-L, facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with DER1 (PubMed:32327568), Both proteins have lateral gates facing each other which form a channel through the ER membrane and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568), Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1, ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1, Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome, ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M


This is Mast/stem cell growth factor receptor Kit protein, from Chicken, contains 960 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis, In response to KITLG/SCF binding, KIT can activate several signaling pathways, Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1, Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B, KIT promotes activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Irregular chiasm C-roughest protein protein, from Fruit fly, contains 764 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Required for correct axonal pathway formation in the optic lobe and for programmed cell death in the developing retina


This is RING-box protein HRT1 protein, from Baker's yeast, contains 121 amino acids, has 1 RING-type Zinc finger.

RING-type

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins, Recruits the E2 ubiquitin-conjugating enzyme CDC34/UBC3 to the complex and brings it into close proximity to the substrate, Also stimulates CDC34/UBC3 autoubiquitination and promotes the neddylation of CDC53 and RTT101, Component of the SCF(CDC4) ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor SIC1 and for the G1-to-S phase transition, Component of the RTT101(MMS1-MMS22) ubiquitin ligase that promotes fork progression through damaged DNA or natural pause sites, Component of the CRL3(ELA1) ubiquitin ligase required for ubiquitination of RPB1, the largest subunit of RNA polymerase II (Pol II), which targets Pol II for proteasomal degradation in DNA-damaged cells


This is Cell growth-regulating nucleolar protein protein, from Mouse, contains 388 amino acids, has 2 C2HC LYAR-type Zinc finger.

C2HC LYAR-type

C2HC LYAR-type

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity), Also acts at the level of transcription regulation, Along with PRMT5, binds embryonic globin promoter (By similarity), Represses the expression of embryonic globin Hbb-y gene (PubMed:25092918), In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity), Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity), Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity), In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity), Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (PubMed:25735755), Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080)


This is Transcription factor GATA-4 protein, from Mouse, contains 441 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:35182466), In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity), Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity), Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity), Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153), Promotes cardiac myocyte enlargement (By similarity), Required during testicular development (By similarity), May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity)


This is Zinc finger and BTB domain-containing protein 14 protein, from Mouse, contains 449 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3', Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene (By similarity), Transcriptional repressor of MYC and thymidine kinase promoters

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Ciliary neurotrophic factor receptor subunit alpha protein, from Rat, contains 372 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to CNTF, The alpha subunit provides the receptor specificity

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Protein YNG1 protein, from Baker's yeast, contains 219 amino acids, has 1 PHD-type; degenerate Zinc finger.

PHD-type; degenerate

Histone-binding component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3, Recruitment of NuA3 to nucleosomes requires methylated histone H3, In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation, YNG1 is required for the HAT activity of NuA3 but not for its integrity, Mediates the interaction of SAS3 with nucleosomes


This is Platelet endothelial cell adhesion molecule protein, from Mouse, contains 727 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity), Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity), Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity), Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity), Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity), Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity), Modulates bradykinin receptor BDKRB2 activation (By similarity), Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity), Induces susceptibility to atherosclerosis (PubMed:19048083)


This is Transcription factor GAGA protein, from Fruit fly, contains 581 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Transcriptional activator that functions by regulating chromatin structure, Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors, Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones, Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3', Binds DNA as an oligomer, May also act as a transcriptional repressor, maintaining the repressed state of genes including lolal, and down-regulating its own transcription, Required for dosage compensation in males and may be involved in oogenesis, Also has a role in nuclear division


This is Histone acetyltransferase ESA1 protein, from Baker's yeast, contains 445 amino acids, has 1 C2HC MYST-type; degenerate Zinc finger.

C2HC MYST-type; degenerate

Catalytic component of the NuA4 histone acetyltransferase (HAT), a multiprotein complex involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (PubMed:9520405, PubMed:12379856, PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:16543223, PubMed:18245364, PubMed:9858608), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A,Z to form H2A,ZK14ac (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608), Acetylation of histones gives a specific tag for epigenetic transcription initiation and elongation (PubMed:16543223, PubMed:19822662), Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608), Involved in cell cycle progression (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608), Recruitment to promoters depends on H3K4me (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608), Also acetylates non-histone proteins, such as ATG3 and PAH1 (PubMed:22539722, PubMed:29765047), Regulates autophagy by acetylating ATG3, controlling interaction the interaction between ATG3 and ATG8 and ATG8 lipidation (PubMed:22539722), Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of PAH1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (PubMed:31699900), Catalyzes histone crotonylation (PubMed:31699900)


This is CMRF35-like molecule 6 protein, from Human, contains 224 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Leukocyte surface antigen CD47 protein, from Human, contains 323 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453), Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:8550562, PubMed:7691831), Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:27742621, PubMed:19004835, PubMed:8550562, PubMed:11509594, PubMed:7691831, PubMed:32679764, PubMed:15383453), Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621), Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity), Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity), Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed:11509594), Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed:15383453), Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity), Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764), In response to THBS1, negatively modulates wound healing (By similarity), Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity), May play a role in membrane transport and/or integrin dependent signal transduction (PubMed:7691831), May prevent premature elimination of red blood cells (By similarity)


This is Tyrosine-protein kinase ITK/TSK protein, from Human, contains 620 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response, Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells, When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK, Phosphorylation leads to ITK autophosphorylation and full activation, Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates, In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty, Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2, Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281), Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity), Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Histone deacetylase complex subunit CTI6 protein, from Baker's yeast, contains 506 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the RPD3C(L) histone deacetylase complex (HDAC), Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor, Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters


This is Zinc finger protein 844 protein, from Human, contains 666 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 7 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

May be involved in transcriptional regulation


This is SET and MYND domain-containing protein 4 protein, from Zebrafish, contains 753 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a critical role in cardiac development (PubMed:30110327), Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (PubMed:30110327)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is E3 ubiquitin-protein ligase ZNRF3 protein, from Western clawed frog, contains 853 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity), Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (PubMed:29769720)


This is Ubiquitin carboxyl-terminal hydrolase 16 protein, from Bovine, contains 826 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator, Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis, In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes, Regulates Hox gene expression via histone H2A deubiquitination, Prefers nucleosomal substrates, Does not deubiquitinate histone H2B, Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit

Belongs to the peptidase C19 family, USP16 subfamily


This is RING finger protein 112 protein, from Bovine, contains 628 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development, During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins, Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage, Exhibits GTPase and E3 ubiquitin-protein ligase activities, Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density

Belongs to the TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily


This is Protein odd-skipped-related 1 protein, from Bovine, contains 267 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development

Belongs to the Odd C2H2-type zinc-finger protein family


This is Trans-acting T-cell-specific transcription factor GATA-3 protein, from Bovine, contains 443 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes, Binds to the consensus sequence 5'-AGATAG-3', Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity), Positively regulates ASB2 expression (By similarity), Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33, Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages


This is Nuclear receptor subfamily 1 group D member 1 protein, from Bovine, contains 613 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1, Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis, Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis, Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG, Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells, Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1, Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway, Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep, In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function, In addition to its activity as a repressor, can also act as a transcriptional activator, In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis, In collaboration with SP1, activates GJA1 transcription in a heme-independent manner (By similarity), Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity), Represses the transcription of CES2 (By similarity), Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity), Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity), Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity), Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity), Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity)


This is Nuclear receptor subfamily 4 group A member 2 protein, from Bovine, contains 598 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development, It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)


This is Sialic acid-binding Ig-like lectin 14 protein, from Human, contains 396 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule, Sialic acid-binding paired receptor which may activate associated receptors

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is Neural/ectodermal development factor IMP-L2 protein, from Fruit fly, contains 267 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Essential developmental role during embryogenesis, in particular the normal development of the nervous system, May be involved in some aspect of cell adhesion


This is Locomotion-related protein Hikaru genki protein, from Fruit fly, contains 958 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Plays a role in the formation of functional neural circuits from the early stages of synapse formation, Has a role in the development of CNS functions involved in locomotor activity


This is Splicing factor U2AF 23 kDa subunit protein, from Fission yeast, contains 216 amino acids, has 2 C3H1-type Zinc finger.

Necessary for the splicing of pre-mRNA, The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns


This is E3 ubiquitin ligase rnf-121 protein, from Caenorhabditis elegans, contains 335 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates such as the beta-integrin subunit pat-3, promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:20357004), Negatively regulates the unfolded protein response to reduce endoplasmic reticulum stress (PubMed:20357004), Required for the cessation of distal tip cell migration at the end of larval morphogenesis (PubMed:22285439), Plays a role in germline and gonad development (PubMed:20357004)


This is Zinc finger protein mex-6 protein, from Caenorhabditis elegans, contains 467 amino acids, has 2 C3H1-type Zinc finger.

Functions with mex-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos (PubMed:10882103, PubMed:18199581), Also affects formation of intestinal cells (PubMed:10882103)


This is E3 ubiquitin ligase rnf-5 protein, from Caenorhabditis elegans, contains 235 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix (PubMed:15210732), Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis (PubMed:20385102, PubMed:15210732), Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting (PubMed:20385102), Plays a role in the cessation of distal tip cell migration at the end of larval morphogenesis (PubMed:22285439), Acts as a negative regulator of autophagy (PubMed:23093945)


This is Zinc finger protein dpff-1 protein, from Caenorhabditis elegans, contains 372 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Probable transcription factor, involved in meiosis and stress protection