This is Estrogen receptor protein, from Rat, contains 600 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP, Can activate the transcriptional activity of TFF1, Also mediates membrane-initiated estrogen signaling involving various kinase cascades, Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity)


This is Estrogen receptor protein, from Chicken, contains 589 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Immunoglobulin kappa variable 4-1 protein, from Human, contains 121 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V segment of the variable domain of immunoglobulins light chain that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is T-cell surface glycoprotein CD4 protein, from Mouse, contains 457 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages


This is H-2 class I histocompatibility antigen, D-37 alpha chain protein, from Mouse, contains 357 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is HLA class II histocompatibility antigen, DO alpha chain protein, from Human, contains 250 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells, Modifies peptide exchange activity of HLA-DM


This is H-2 class II histocompatibility antigen, A-Q beta chain protein, from Mouse, contains 265 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-K beta chain protein, from Mouse, contains 263 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-S beta chain protein, from Mouse, contains 263 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is H-2 class II histocompatibility antigen, A-F beta chain protein, from Mouse, contains 252 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Progesterone receptor protein, from Human, contains 933 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone


This is Protein E6 protein, from Human papillomavirus type 18, contains 158 amino acids, has 2  Zinc finger.

Plays a major role in the induction and maintenance of cellular transformation, Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT), The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis, E6 also inhibits immune response by interacting with host IRF3 and TYK2, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway

Belongs to the papillomaviridae E6 protein family


This is Glucocorticoid receptor protein, from Rat, contains 795 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Has transcriptional activation and repression activity, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression


This is Glucocorticoid receptor protein, from Mouse, contains 792 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300), Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity), Loses this transcription modulator function on its own (By similarity), Has no hormone-binding activity (PubMed:20660300), May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300), Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (By similarity), Directly regulates STAT1 expression in isoform Alpha-independent manner (By similarity)


This is DNA topoisomerase 1 protein, from Escherichia coli (strain K12), contains 865 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is T-cell surface antigen CD2 protein, from Human, contains 351 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types, CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function


This is Carcinoembryonic antigen-related cell adhesion molecule 5 protein, from Human, contains 702 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Receptor for E,coli Dr adhesins, Binding of E,coli Dr adhesins leads to dissociation of the homodimer

Belongs to the immunoglobulin superfamily, CEA family


This is Myelin protein P0 protein, from Rat, contains 248 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system, It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction


This is Beta-2-microglobulin protein, from Rat, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system

Belongs to the beta-2-microglobulin family


This is Protein krueppel protein, from Fruit fly, contains 502 amino acids, has 5 C2H2-type Zinc finger.

Krueppel is a gap class segmentation protein, It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Transcription elongation factor S-II protein, from Baker's yeast, contains 309 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Can promote the transfer of one strand of a double-stranded DNA molecule to a homologous single strand and thus may be involved in recombination


This is Macrophage colony-stimulating factor 1 receptor protein, from Human, contains 972 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes, Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development, Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy, Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion, Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (PubMed:20504948, PubMed:30982609), Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL, Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD, Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway, Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1, Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2, Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B, Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1, Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor, In the central nervous system, may play a role in the development of microglia macrophages (PubMed:30982608)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Gag polyprotein protein, from MPMV, contains 657 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag-Pro polyprotein protein, from MPMV, contains 911 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Enhances the activity of the reverse transcriptase, May be part of the mature RT


This is Serendipity locus protein delta protein, from Fruit fly, contains 433 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional activator that controls bicoid gene expression during oogenesis, Found in transcriptionally active cells, Binds to specific sites on polytene chromosomes of third instar larvae, Binds to the consensus DNA sequence 5'-YTAGAGATGGRAA-3'


This is Myelin-associated glycoprotein protein, from Rat, contains 626 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:8995428, PubMed:9298990), Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination, Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2, Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity), Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868), In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides (PubMed:17640868), In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (PubMed:19367338), Inhibits axon longitudinal growth (PubMed:9298990), Inhibits axon outgrowth by binding to RTN4R (By similarity), Preferentially binds to alpha-2,3-linked sialic acid (PubMed:8995428), Binds ganglioside Gt1b (PubMed:8995428)

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is T-cell surface glycoprotein CD8 alpha chain protein, from Rat, contains 236 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex, The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs), This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells, In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells, CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells


This is T-cell surface glycoprotein CD3 epsilon chain protein, from Human, contains 207 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098), In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development, Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E, Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128)


This is Progesterone receptor protein, from Chicken, contains 786 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues


This is tRNA dimethylallyltransferase protein, from Baker's yeast, contains 428 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in the anticodon loop on a specific subset of tRNAs both in the cytosol and the mitochondrion, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A), This modification optimizes the codon:anticodon fit in the ribosome and promotes translational fidelity, Competes with the farnesyl pyrophosphate synthase ERG20 for the common substrate dimethylallyl diphosphate (DMAPP)


This is Protein snail protein, from Fruit fly, contains 390 amino acids, has 5 C2H2-type Zinc finger.

Essential for the correct specification of ventral-dorsal patterns

Belongs to the snail C2H2-type zinc-finger protein family


This is Early growth response protein 1 protein, from Mouse, contains 533 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator (PubMed:8336701, PubMed:8703054, PubMed:15958557), Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:8703054, PubMed:15958557, PubMed:2028256, PubMed:8939742), Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity), Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557), Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557), Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation (PubMed:15958557), Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy (PubMed:15265859), Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia (PubMed:11100120), Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (PubMed:8703054), Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription (PubMed:26471974), Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (PubMed:29138967)

Belongs to the EGR C2H2-type zinc-finger protein family


This is Transcription factor Sp1 protein, from Human, contains 785 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli, Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses, Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation), Binds also the PDGFR-alpha G-box promoter, May have a role in modulating the cellular response to DNA damage, Implicated in chromatin remodeling, Plays an essential role in the regulation of FE65 gene expression, In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression, Isoform 3 is a stronger activator of transcription than isoform 1, Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247, PubMed:21046154), Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter, Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Zinc finger Y-chromosomal protein protein, from Human, contains 801 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Probable transcriptional activator, Binds to the consensus sequence 5'-AGGCCY-3'

Belongs to the krueppel C2H2-type zinc-finger protein family, ZFX/ZFY subfamily


This is Low affinity immunoglobulin gamma Fc region receptor II protein, from Mouse, contains 330 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the Fc region of complexed immunoglobulins gamma, Low affinity receptor, Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells, Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis, Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits, Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively


This is E3 SUMO-protein ligase EGR2 protein, from Mouse, contains 470 amino acids, has 3 C2H2-type Zinc finger.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity


This is Transcriptional factor SWI5 protein, from Baker's yeast, contains 709 amino acids, has 3 C2H2-type Zinc finger.

Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast, Recognizes a specific sequence in the promoter of the HO gene, Activates EGT2 transcription in a concentration-dependent manner, Synthesized during G2 and early mitosis


This is Early growth response protein 1 protein, from Rat, contains 508 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator (PubMed:8413279), Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:15220929), Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity), Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia, Plays a role in the regulation of cell survival, proliferation and cell death, Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation, Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy, Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia, Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity), Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription, Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity), Regulates biosynthesis of glucocorticoid receptor GR/NR3C1 in the hippocampus and thereby may play a role in the behavioral and hypothalamic-pituitary-adrenal responses to stress in offspring (PubMed:15220929)


This is Krueppel homolog 1 protein, from Fruit fly, contains 845 amino acids, has 8 C2H2-type Zinc finger.

Plays a general role in the hierarchies of gene expression leading to metamorphosis


This is Mineralocorticoid receptor protein, from Human, contains 984 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol, Binds to mineralocorticoid response elements (MRE) and transactivates target genes, The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels


This is E3 ubiquitin-protein ligase ICP0 protein, from HHV-1, contains 775 amino acids, has 1 RING-type Zinc finger.

RING-type

SUMO-targeted ubiquitin ligase that plays an essential role in nuclear antiviral defense evasion triggered by dsDNA viruses (PubMed:32001251), Acts during the initial stages of lytic infection and the reactivation of latent viral genome, Prevents the antiviral effect of nuclear bodies by degrading host PML, SP100 and MORC3 (PubMed:27440897, PubMed:34759314), Prevents antiviral response to viral DNA induced by IFI16 by degrading it, Additionally, inhibits host IRF3 nuclear signaling to prevent interferon production by the infected cells, Interestingly, the E3 ubiquitin ligase activity associated with the RING finger domain does not seem to be directly required to inhibit the activation of IRF3 but instead plays a critical role in modulating the cellular localization of ICP0, Upon reactivation of latent genome, suppresses the silencing of viral DNA by dissociating either HDAC1 or HDAC2 from the HDAC-RCOR1-REST-KDM1A complex localized at the ND10 structures and causes their dispersal, Two cellular histone ubiquitin ligases RNF8 and RNF168 are also targeted by ICP0 for degradation, leading to a loss of ubiquitinated forms of H2A, a relief of transcriptional repression, and the activation of latent viral genomes, Enhances the localization of host CCND3 to ND10 bodies that serve as precursors of replication compartments to enable efficient viral replication, Like many RING-finger E3 ubiquitin ligases, ICP0 can induce its own ubiquitination, an activity that promotes its instability due to its targeting to the 26S proteasome for degradation, ICP0 restricts this process by recruiting the cellular ubiquitin-specific protease USP7 that cleaves the anchored ubiquitin chains from ICP0, thereby promoting its stabilization

Belongs to the simplexviruses ICp0 family


This is Low affinity immunoglobulin gamma Fc region receptor III protein, from Mouse, contains 261 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the Fc region of complexed immunoglobulins gamma, Low affinity receptor which binds to IgG1, IgG2a and IgG2b (PubMed:17558411), Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (PubMed:18097064)


This is Chaperone protein DnaJ protein, from Escherichia coli (strain K12), contains 376 amino acids, has 1 CR-type Zinc finger.

CR-type

Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids, Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding


This is Tyrosine-protein kinase Btk29A protein, from Fruit fly, contains 786 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Required for proper ring canal development, Also required for the development of male genitalia and for adult survival

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Human, contains 254 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Involved in Dengue virus pathogenesis via antibody-dependent enhancement (ADE) mechanism, Secondary infection with Dengue virus triggers elevated levels of afucosylated non-neutralizing IgG1s with reactivity to viral envelope/E protein, Viral antigen-IgG1 complexes bind with high affinity to FCGR3A, facilitating virus entry in myeloid cells and subsequent viral replication


This is Interleukin-6 receptor subunit alpha protein, from Human, contains 468 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:21990364), The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling', sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed:21990364), In complex with IL6, is required for induction of VEGF production (PubMed:12794819), Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity), 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity)

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is T-cell surface antigen CD2 protein, from Mouse, contains 344 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types, CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function


This is T-cell surface antigen CD2 protein, from Rat, contains 344 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type


This is Protein suppressor of hairy wing protein, from Fruit fly, contains 941 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 10 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 1; atypical

C2H2-type 3; atypical

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators, Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes, Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV), Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops, This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery, Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190


This is Eukaryotic translation initiation factor 2 subunit beta protein, from Baker's yeast, contains 285 amino acids, has 1 C4-type Zinc finger.

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex, Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex, In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B


This is Protein kinase C delta type protein, from Rat, contains 673 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Protein kinase C epsilon type protein, from Rat, contains 737 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis, Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts, Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes, Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein, In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact, Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration, During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA, In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1, During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length, Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3), Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement, May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation, Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol, Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons, Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2,2), Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production, In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2, May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1, Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (By similarity)


This is Protein kinase C zeta type protein, from Rat, contains 592 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in late synaptic long term potentiation phase in CA1 hippocampal cells and long term memory maintenance


This is U1 small nuclear ribonucleoprotein C protein, from Human, contains 159 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region

Belongs to the U1 small nuclear ribonucleoprotein C family


This is CD48 antigen protein, from Human, contains 243 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:27249817, PubMed:12007789), Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291), In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789), Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (PubMed:9841922, PubMed:27249817)


This is T-cell antigen CD7 protein, from Human, contains 240 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Macrophage colony-stimulating factor 1 receptor protein, from Mouse, contains 977 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes, Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development, Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy, Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion, Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity), Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL, Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD, Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway, Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1, Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2, Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B, Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1, Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor, In the central nervous system, may play a role in the development of microglia macrophages (By similarity)


This is T-cell surface glycoprotein CD3 gamma chain protein, from Human, contains 182 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098), In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769), Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G


This is Unique short US11 glycoprotein protein, from HHV-5, contains 215 amino acids, has 1 Ig-like H-type Immunoglobulin domain.

Ig-like H-type

Participates in the inhibition of the host immune response, Redirects newly synthesized major histocompatibility complex (MHC) class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction, In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes

Belongs to the cytomegalovirus US6 family


This is Cytotoxic T-lymphocyte protein 4 protein, from Mouse, contains 223 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor acting as a major negative regulator of T-cell responses, The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28


This is UvrABC system protein A protein, from Escherichia coli (strain K12), contains 940 amino acids, has 2 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate

Belongs to the ABC transporter superfamily, UvrA family


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Escherichia coli (strain K12), contains 304 amino acids, has 1 C4-type Zinc finger.

Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA, Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA, Increasing amounts of mRNA also inhibit enzyme activity


This is RNA polymerase-binding transcription factor DksA protein, from Escherichia coli (strain K12), contains 151 amino acids, has 1 dksA C4-type Zinc finger.

dksA C4-type

Transcription factor that acts by binding directly to the RNA polymerase (RNAP), Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters, Also required for regulation of fis expression, Binding to RNAP disrupts interaction of RNAP with DNA, inhibits formation of initiation complexes, and amplifies effects of ppGpp and the initiating NTP on rRNA transcription, Inhibits transcript elongation, exonucleolytic RNA cleavage and pyrophosphorolysis, and increases intrinsic termination, Also involved, with RecN, in repair of DNA double-strand breaks, Required, probably upstream of the two-component system BarA-UvrY, for expression of CsrA-antagonistic small RNAs CsrB and CsrC (PubMed:21488981)


This is DNA primase protein, from Escherichia coli (strain K12), contains 581 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is Hepatitis A virus cellular receptor 2 homolog protein, from Rat, contains 282 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor implicated in modulating innate and adaptive immune responses, Generally accepted to have an inhibiting function, Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand, Regulates macrophage activation, Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance, In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion, The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN, Expressed on Treg cells can inhibit Th17 cell responses, Receptor for LGALS9, Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6, Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens, Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth, However, the function as receptor for LGALS9 has been challenged (By similarity), Also reported to enhance CD8+ T cell responses to an acute infection such as by Listeria monocytogenes, Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent, May recognize PtSer on apoptotic cells leading to their phagocytosis, Mediates the engulfment of apoptotic cells by dendritic cells, Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells, Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha, In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes, Can enhance mast cell production of Th2 cytokines Il-4, IL-6 and IL-13, Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9, In contrast, shown to suppress NK cell-mediated cytotoxicity, Negatively regulates NK cell function in LPS-induced endotoxic shock

Belongs to the immunoglobulin superfamily, TIM family


This is Platelet glycoprotein VI protein, from Mouse, contains 313 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Collagen receptor involved in collagen-induced platelet adhesion and activation (PubMed:16139873, PubMed:24368846), Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation, This procoagulant function may contribute to arterial and venous thrombus formation, The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2


This is Leucine-rich repeat-containing protein 4B protein, from Mouse, contains 709 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Synaptic adhesion protein, Regulates the formation of excitatory synapses, The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity)


This is Gag polyprotein protein, from HIV-1, contains 497 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Gag polyprotein protein, from HTLV-1, contains 429 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Binds strongly to viral nucleic acids and promote their aggregation, Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs


This is Gag-Pro polyprotein protein, from HTLV-1, contains 651 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell (Potential), Cleaves the translation initiation factor eIF4G leading to the inhibition of host cap-dependent translation (By similarity)


This is Palladin protein, from Rat, contains 603 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cytoskeletal protein required for organization of normal actin cytoskeleton, Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types, May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays, Binds to proteins that bind to either monomeric or filamentous actin, Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles, Different isoforms may have functional differences, Plays a role in neurite outgrowth and in the establishment of polarity during neuronal morphogenesis, Participates in the acquisition of the reactive astrocyte morphology


This is Histone-lysine N-methyltransferase PRDM9 protein, from Rat, contains 796 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination, Can also methylate all four core histones with H3 being the best substrate and the most highly modified, Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate, During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity, Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression, During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema, EWSR1 joins PRDM9 with the chromosomal axis through REC8, In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation, Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation, In addition performs automethylation, Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Gag polyprotein protein, from ALV-A RSA, contains 701 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Aspartyl protease that mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell


This is Leucine-rich repeat and fibronectin type III domain-containing protein 1 protein, from Rat, contains 766 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Promotes neurite outgrowth in hippocampal neurons (By similarity), Involved in the regulation of the differentiation and maintenance of excitatory synapses, Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1


This is Zinc finger protein 688 protein, from Human, contains 276 amino acids, has 2 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Leucine-rich repeat-containing protein 4B protein, from Rat, contains 709 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Synaptic adhesion protein, Regulates the formation of excitatory synapses, The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner


This is Forkhead box protein P2 protein, from Rat, contains 710 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium, May also play a role in developing neural, gastrointestinal and cardiovascular tissues, Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity), Plays a role in synapse formation by regulating SRPX2 levels


This is Lysine-specific demethylase 7B protein, from Zebrafish, contains 577 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone demethylase required for brain development, Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity)

Belongs to the JHDM1 histone demethylase family, JHDM1D subfamily


This is Immunoglobulin lambda constant 1 protein, from Human, contains 106 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Constant region of immunoglobulin light chains, Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)


This is Zinc finger protein 703 protein, from Mouse, contains 594 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters, Regulates cell adhesion, migration and proliferation, May be required for segmental gene expression during hindbrain development


This is Histone acetyltransferase ESA1 protein, from Filobasidiella neoformans, contains 564 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (By similarity), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation, The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity), Recruitment to promoters depends on H3K4me, Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity)


C2HC MYST-type


This is Chaperone protein dnaJ A7A, chloroplastic protein, from Rice, contains 447 amino acids, has 1 CR-type Zinc finger.

CR-type

Plays pivotal roles in chloroplast development, Is essential for the regulation of chloroplast development and differentiation


This is Chaperone protein dnaJ A7B, chloroplastic protein, from Rice, contains 447 amino acids, has 1 CR-type Zinc finger.

CR-type


This is FCS-Like Zinc finger 17 protein, from Mouse-ear cress, contains 126 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is Gag-Pro polyprotein protein, from BLV, contains 571 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell


CCHC-type

CCHC-type


This is DNA (cytosine-5)-methyltransferase 3C protein, from Mouse, contains 740 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

DNA methyltransferase that specifically methylates the promoters of evolutionarily young retrotransposons in the male germline (PubMed:27856912, PubMed:28854222), De novo methylation and subsequent repression of transposable elements prevents their mobilization, which is essential for germline integrity (PubMed:27856912, PubMed:28854222)

Belongs to the class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family


This is Immunoglobulin lambda constant 2 protein, from Human, contains 106 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda constant 3 protein, from Human, contains 106 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is E3 ubiquitin-protein ligase RNF43 protein, from Western clawed frog, contains 689 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled, Acts on both canonical and non-canonical Wnt signaling pathway (By similarity), Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (PubMed:29769720)


This is M1-specific T cell receptor alpha chain protein, from Human, contains 268 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

The alpha chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV), Classified as a public TR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers and confers long-lived immunity against IAV infection, Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains (PubMed:1833769, PubMed:7807026, PubMed:29997621, PubMed:27036003, PubMed:12796775, PubMed:18275829), Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity)


This is M1-specific T cell receptor beta chain protein, from Human, contains 310 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

The beta chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV), Classified as a public TCR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers/individuals and confers long-lived immunity against IAV infection, Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains (PubMed:1833769, PubMed:7807026, PubMed:29997621, PubMed:27036003, PubMed:12796775, PubMed:18275829), Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity)


This is ORF8 protein protein, from 2019-nCoV, contains 121 amino acids, has 1 SARS ORF8 Ig-like Immunoglobulin domain.

SARS ORF8 Ig-like

Plays a role in modulating the host immune response (PubMed:31986261, PubMed:35343786, PubMed:36689483), May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increased secretion of pro-inflammatory factors (PubMed:35343786, PubMed:36689483), Contributes to the cytokine storm during SARS-CoV-2 infection when secreted by unconventional pathway (PubMed:33723527, PubMed:36689483), May act by down-regulating major histocompability complex class I (MHC-I) at cell surface (PubMed:34021074, PubMed:35157849), May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 (PubMed:34177923)


This is T cell receptor alpha chain MC.7.G5 protein, from Human, contains 275 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

The alpha chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule, On CD8-positive T cell clone MC,7,G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells, Mediates cancer cell cytotoxicity in an HLA-independent manner, Has no reactivity to healthy cells, even stressed or infected by bacteria (PubMed:31959982), Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity)


This is T cell receptor beta chain MC.7.G5 protein, from Human, contains 315 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

The beta chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule, On CD8-positive T cell clone MC,7,G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells, Mediates cancer cell cytotoxicity in an HLA-independent manner, Has no reactivity to healthy cells even stressed or infected by bacteria (PubMed:31959982), Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity)


This is C2H2 type master regulator of conidiophore development brlA protein, from Aspergillus nidulans, contains 432 amino acids, has 2 C2H2-type Zinc finger.

BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (PubMed:8508769, PubMed:5366214, PubMed:2823119, PubMed:2655931, PubMed:2196567, PubMed:7704830), They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (PubMed:2823119, PubMed:2655931, PubMed:2108321), Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (PubMed:8417986), Controls the expression of the conidiophore-specific phenol oxidase ivoB (PubMed:1901560), Controls the expression of the hydrophobin rodA (PubMed:2065971), Mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores (PubMed:3293800), Expression of brlA leads to activation of abaA, wetA and stuA, cessation of vegetative growth, cellular vacuolization and spore formation


This is Zinc finger and SCAN domain-containing protein 22 protein, from Human, contains 491 amino acids, has 8 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Telomere zinc finger-associated protein protein, from Human, contains 688 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411), Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411), Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411), Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257), Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257), Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177), Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891)


This is Protein kinase C alpha type protein, from Rabbit, contains 672 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP, Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle, Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation, In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B, Depending on the cell type, exhibits anti-apoptotic function and protects cells from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, or mediates anti-apoptotic action by phosphorylating BCL2, During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development, After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion, Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility, During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42, Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries, Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area, Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility, In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation, Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation, In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion, During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation, But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA), Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation, Phosphorylates KIT, leading to inhibition of KIT activity, Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription, Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity)


This is mRNA export factor protein, from HHV-1, contains 512 amino acids, has 1 CHC2-type Zinc finger.

Multifunctional regulator of the expression of viral genes that contributes to the shutoff of host protein synthesis and mediates nuclear export of viral intronless mRNAs, Early in infection, this immediate early (EI) protein mediates the inhibition of cellular splicing, This results in the accumulation of unprocessed 3'end pre-mRNAs which can't be exported from the nucleus, Cellular protein synthesis is thereby shut off early after virus infection, Later in the infection, it helps recruit cellular RNA polymerase II to viral replication sites and promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP, ICP27 binds to NUP62 which may provide facilitated viral mRNA export and may indirectly compete with some host cell transport receptors for binding and inhibit cellular nucleocytoplasmic transport pathways (PubMed:22334672), Also stimulates translation of viral transcripts, Repression of host gene expression blocks the cell cycle at the G1 phase and prevents apoptosis, Seems to silence the 3' splice site of the promyelocytic leukemia (PML) intron 7a, thereby switching PML isoforms from PML-II to PML-V, This could be linked to the accelerated mRNA export induced by ICP27 which might not provide sufficient time for PML pre-mRNA to be spliced in the nucleus

Belongs to the HHV-1 ICP27 protein family


This is CD48 antigen protein, from Rat, contains 240 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation, Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex, In turn, promotes LCK phosphorylation and subsequent activation, Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells


This is Gag polyprotein protein, from MMTV, contains 591 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag polyprotein protein, from Feline leukemia virus, contains 506 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Involved in the packaging and encapsidation of two copies of the genome, Binds with high affinity to conserved elements within the packaging signal, located near the 5'-end of the genome, This binding is dependent on genome dimerization


This is Gag-Pro polyprotein protein, from MMTV, contains 860 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag-Pro polyprotein protein, from HTLV-1, contains 651 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell, Cleaves the translation initiation factor eIF4G leading to the inhibition of host cap-dependent translation


This is Androgen receptor protein, from Human, contains 920 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Retinoic acid receptor alpha protein, from Human, contains 462 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566), Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758), The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758, PubMed:19398580), In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524), On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566), Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758), Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758), RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity), Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity), In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity), In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity), Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758), In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is T-cell surface glycoprotein CD8 beta chain protein, from Mouse, contains 213 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex, The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched, Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs), Additionally, plays a critical role in thymic selection of CD8+ T-cells


This is HLA class I histocompatibility antigen, C alpha chain protein, from Human, contains 366 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

ALLELE C*15:02: Presents CMV epitope derived from UL83 CC (VVCAHELVC) to CD8-positive T cells, triggering T cell cytotoxic response


This is Serine/threonine-protein kinase A-Raf protein, from Human, contains 606 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is Myelin protein P0 protein, from Bovine, contains 248 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system, It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction


This is Nuclear receptor subfamily 2 group F member 6 protein, from Human, contains 404 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor predominantly involved in transcriptional repression, Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors, Involved in modulation of hormonal responses, Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene, Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner, The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6, Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity, Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity, Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is COUP transcription factor 1 protein, from Human, contains 423 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription, Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif, Represses transcriptional activity of LHCG


This is Transcription elongation factor A protein 1 protein, from Mouse, contains 301 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus


This is Mast/stem cell growth factor receptor Kit protein, from Human, contains 976 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis, In response to KITLG/SCF binding, KIT can activate several signaling pathways, Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL, Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B, Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Zygotic gap protein knirps protein, from Fruit fly, contains 429 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor, Binds to multiple sites in the eve stripe 3 enhancer element, Plays an essential role in the segmentation process both by refining the expression patterns of gap genes and by establishing pair-rules stripes of gene expression

Belongs to the nuclear hormone receptor family, NR0 subfamily


This is T-cell-specific surface glycoprotein CD28 protein, from Human, contains 220 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival, Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933), Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037)


This is Transcriptional repressor Rhit protein, from Mouse, contains 512 amino acids, has 8 C2H2-type Zinc finger.

Transcriptional repressor that binds to the promoter region of Mpv17l isoform M-LP short and regulates its age-dependent and heat-induced expression (PubMed:20231359), By regulating Mpv17l expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade (PubMed:20231359) (By similarity)


This is Retinoic acid receptor beta protein, from Human, contains 455 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770), The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580), In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity)


This is Thyroid hormone receptor alpha protein, from Human, contains 490 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action


This is Thyroid hormone receptor beta protein, from Human, contains 461 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine


This is Protein kinase C gamma type protein, from Rabbit, contains 697 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress, Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression, In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning, May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity, May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain, May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors, May also contributes to chronic morphine-induced changes in nociceptive processing, Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation, Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors, During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury, Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum (By similarity), Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress, Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage, Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding, Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Protein kinase C epsilon type protein, from Rabbit, contains 736 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis, Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts, Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes, Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein, In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact, Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration, During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA, In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1, During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length, Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3), Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement, May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation, Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol, Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons, Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2,2), Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production, In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2, May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1 (By similarity), Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (By similarity)