This is Endonuclease 8 protein, from Salmonella choleraesuis (strain SC-B67), contains 263 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Chaperone protein DnaJ protein, from Salmonella choleraesuis (strain SC-B67), contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Structure-specific endonuclease subunit SLX1 homolog protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 511 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA


This is Probable carbamoyltransferase HypF protein, from Methanococcus jannaschii, contains 766 amino acids, has 2 C4-type Zinc finger.

Involved in the maturation of [NiFe] hydrogenases, Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases, HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide

Belongs to the carbamoyltransferase HypF family


This is Replication factor A protein, from Methanococcus jannaschii, contains 645 amino acids, has 1 C4-type Zinc finger.

Probably plays an essential for replication of the chromosome, DNA recombination and repair (By similarity), Binds approximately 20 nucleotides


This is TRAF-type zinc finger domain-containing protein 1 protein, from Bovine, contains 580 amino acids, has 1 TRAF-type Zinc finger.

TRAF-type

Negative feedback regulator that controls excessive innate immune responses, Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways, May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation, May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity)


This is Tripartite motif-containing protein 54 protein, from Bovine, contains 366 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

May bind and stabilize microtubules during myotubes formation


This is Rab effector Noc2 protein, from Bovine, contains 292 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells


This is Neurotrimin protein, from Bovine, contains 345 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, IgLON family


This is Inducible T-cell costimulator protein, from Bovine, contains 209 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells, Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens, Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10, Prevents the apoptosis of pre-activated T-cells, Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)


This is XIAP-associated factor 1 protein, from Bovine, contains 297 amino acids, has 1 TRAF-type Zinc finger.

TRAF-type

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family, Inhibits anti-caspase activity of BIRC4, Induces cleavage and inactivation of BIRC4 independent of caspase activation, Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells, May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway, After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria, Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm, The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4, Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL, May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity)


This is Transcriptional repressor RHIT protein, from Bovine, contains 550 amino acids, has 8 C2H2-type Zinc finger.

Transcriptional repressor involved in regulating MPV17L expression, By regulating MPV17L expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Forkhead box protein P1 protein, from Chicken, contains 686 amino acids, has 1 C2H2-type Zinc finger.


This is Zinc finger protein PLAG1 protein, from Chicken, contains 501 amino acids, has 7 C2H2-type Zinc finger.

Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation


This is Formamidopyrimidine-DNA glycosylase protein, from Ensifer meliloti, contains 301 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is U1 small nuclear ribonucleoprotein C protein, from Yeast, contains 150 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region

Belongs to the U1 small nuclear ribonucleoprotein C family


This is Transcriptional regulator MNL1 protein, from Yeast, contains 905 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor that activates stress response genes via SLE (STRE-like) elements, Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress, Activates a subset of the genes that are repressed by NRG1


This is Transcriptional regulator RPN4 protein, from Yeast, contains 536 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional activator of a number of genes encoding proteasomal subunits, Binds to the DNA sequence 5'-GAAGGCAAAA-3', enriched in regions upstream of proteasome genes


This is Pre-mRNA-splicing factor CWC2 protein, from Yeast, contains 363 amino acids, has 1 C3H1-type Zinc finger.

Involved in the first step of pre-mRNA splicing, Required for cell growth and cell cycle control, Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex, May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA, Associates predominantly with U6 snRNAs in assembled active spliceosomes, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity)


This is Transcriptional regulatory protein GAT1 protein, from Yeast, contains 688 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources, Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C,albicans, Influences the filamentation process depending upon the nitrogen sources available, Required for virulence in a mouse systemic infection model


This is Protein FYV10 protein, from Yeast, contains 572 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase


This is SAGA-associated factor 11 protein, from Yeast, contains 120 amino acids, has 1 SGF11-type Zinc finger.

Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination, SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), Involved in transcriptional regulation of a subset of SAGA-regulated genes, Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B


This is Postreplication repair E3 ubiquitin-protein ligase RAD18 protein, from Yeast, contains 378 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group, Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA


This is JmjC domain-containing histone demethylation protein 1 protein, from Yeast, contains 478 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code

Belongs to the JHDM1 histone demethylase family


This is Vacuolar protein sorting-associated protein 27 protein, from Yeast, contains 841 amino acids, has 1 FYVE-type; atypical Zinc finger.

FYVE-type; atypical

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane


This is Branchpoint-bridging protein protein, from Yeast, contains 455 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Necessary for the splicing of pre-mRNA, Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity)


This is Transcriptional regulator STP4 protein, from Yeast, contains 376 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor involved in response to cell wall damage


This is Transcription elongation factor SPT4 protein, from Yeast, contains 112 amino acids, has 1 C4-type Zinc finger.

The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing, This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity)


This is Protein fyv10 protein, from Aspergillus nidulans, contains 406 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type


This is Structure-specific endonuclease subunit slx1 protein, from Aspergillus nidulans, contains 409 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA


This is Pre-mRNA-splicing factor slu7 protein, from Aspergillus nidulans, contains 466 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is C2H2-type zinc-finger transcription factor protein, from Aspergillus nidulans, contains 277 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

C2H2-type zinc-finger transcription factor that controls the expression of the nonribosomal peptide synthases inpA and inpB, as well as of the other inp cluster-associated genes (PubMed:20952652, PubMed:27294372), Mediates also the expression of the asperfuranone biosynthesis gene cluster by binding to the afoA promoter (PubMed:20952652), Probably recognizes the 5'-CT/C/AAAAGGAT/AT/GG/CA-3' motif in the promoters of teget genes (PubMed:20952652)

Belongs to the GLI C2H2-type zinc-finger protein family


This is Pre-mRNA-splicing factor cwc2 protein, from Aspergillus nidulans, contains 417 amino acids, has 1 C3H1-type Zinc finger.


This is Vacuolar protein sorting-associated protein 27 protein, from Aspergillus nidulans, contains 715 amino acids, has 1 FYVE-type; degenerate Zinc finger.

FYVE-type; degenerate


This is U1 small nuclear ribonucleoprotein C protein, from Aspergillus nidulans, contains 236 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type


This is E3 ubiquitin-protein ligase TRIM45 protein, from Bovine, contains 580 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response, Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response, May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway


This is PHD finger protein 23A protein, from Zebrafish, contains 296 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Acts as a negative regulator of autophagy


This is T-cell surface protein tactile protein, from Rat, contains 603 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response, Promotes NK cell-target adhesion by interacting with PVR present on target cells, May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity)


This is ERI1 exoribonuclease 2 protein, from Mouse, contains 688 amino acids, has 1 GRF-type Zinc finger.

GRF-type


This is VIN3-like protein 3 protein, from Mouse-ear cress, contains 529 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Involved in both the vernalization and photoperiod pathways by regulating gene expression


This is Zinc finger protein 805 protein, from Human, contains 627 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Probable ribonuclease ZC3H12C protein, from Mouse, contains 884 amino acids, has 1 C3H1-type Zinc finger.

May function as RNase and regulate the levels of target RNA species


This is RING finger protein 150 protein, from Mouse, contains 437 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Zinc finger protein 652 protein, from Mouse, contains 608 amino acids, has 7 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 9; degenerate

Functions as a transcriptional repressor


This is Chaperone protein DnaJ protein, from Vibrio fischeri, contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Vibrio fischeri, contains 294 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Formamidopyrimidine-DNA glycosylase protein, from Vibrio fischeri, contains 272 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Eukaryotic translation initiation factor 2 subunit 2 protein, from Bovine, contains 333 amino acids, has 1 C4-type Zinc finger.

Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC), Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex, In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B


This is Tripartite motif-containing protein 10 protein, from Bovine, contains 489 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells, May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity), In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity, Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (By similarity)


This is Transcription factor Sp2 protein, from Bovine, contains 613 amino acids, has 3 C2H2-type Zinc finger.

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Stromal membrane-associated protein 2 protein, from Bovine, contains 429 amino acids, has 1 C4-type Zinc finger.

GTPase activating protein that acts on ARF1, Can also activate ARF6 (in vitro), May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity)


This is Myelin protein zero-like protein 2 protein, from Bovine, contains 215 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Zinc finger protein 410 protein, from Bovine, contains 467 amino acids, has 5 C2H2-type Zinc finger.

Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells, Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells, May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence, May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose, However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4


This is RING-H2 finger protein ATL43 protein, from Mouse-ear cress, contains 407 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Belongs to the RING-type zinc finger family, ATL subfamily


This is Putative zinc finger protein 542 protein, from Human, contains 170 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate


This is RING1 and YY1-binding protein B protein, from Zebrafish, contains 257 amino acids, has 1 RanBP2-type Zinc finger.

May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1


This is E3 ubiquitin-protein ligase RNF166 protein, from Chicken, contains 244 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates


This is SET and MYND domain-containing protein 4 protein, from Chicken, contains 742 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a critical role in cardiac development, Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is WW domain-binding protein 4 protein, from Chicken, contains 398 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the spliceosome, May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex


This is Transcription initiation factor TFIID subunit 3 protein, from Chicken, contains 930 amino acids, has 1 PHD-type Zinc finger.

PHD-type

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription, TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC), The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13, The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C, TAF3 forms the TFIID-A module together with TAF5 and TBP, Required in complex with TBPL2 for the differentiation of myoblasts into myocytes, The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process


This is G2/M phase-specific E3 ubiquitin-protein ligase protein, from Chicken, contains 742 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 2 PHD-type Zinc finger, has 1 PHD-type 2; degenerate Zinc finger.

C2HC pre-PHD-type

PHD-type

PHD-type 2; degenerate

PHD-type

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Essential in early embryonic development to prevent apoptotic death


This is Chaperone protein DnaJ protein, from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090), contains 373 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090), contains 275 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is SAGA-associated factor 11 protein, from Fission yeast, contains 117 amino acids, has 1 SGF11-type Zinc finger.

Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination, SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), Involved in transcriptional regulation of a subset of SAGA-regulated genes, Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B


This is Chaperone protein DnaJ protein, from Ehrlichia ruminantium (strain Gardel), contains 382 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM), contains 276 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Formamidopyrimidine-DNA glycosylase protein, from Gluconobacter suboxydans, contains 277 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Gluconobacter suboxydans, contains 289 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Gluconobacter suboxydans, contains 380 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Cleavage and polyadenylation specificity factor subunit 4 protein, from Rat, contains 243 amino acids, has 5 C3H1-type Zinc finger, has 1 CCHC-type Zinc finger.

CCHC-type

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition, CPSF4 binds RNA polymers with a preference for poly(U)


This is Nucleoporin NUP42 protein, from Western clawed frog, contains 449 amino acids, has 1 C3H1-type Zinc finger.

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm


This is E3 ubiquitin-protein ligase NRDP1 protein, from African clawed frog, contains 317 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins


This is Nectin-4 protein, from Western clawed frog, contains 532 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type


This is Zinc finger protein 513 protein, from Rat, contains 541 amino acids, has 8 C2H2-type Zinc finger.

Transcriptional regulator that plays a role in retinal development and maintenance


This is Chaperone protein DnaJ protein, from Wolbachia sp. subsp. Brugia malayi (strain TRS), contains 374 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Formamidopyrimidine-DNA glycosylase protein, from Wolbachia sp. subsp. Brugia malayi (strain TRS), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85), contains 295 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Chaperone protein DnaJ protein, from Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85), contains 376 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Zinc finger CCCH domain-containing protein 15 protein, from Chicken, contains 429 amino acids, has 2 C3H1-type Zinc finger.

Protects DRG1 from proteolytic degradation


This is Zinc finger matrin-type protein 1 protein, from Human, contains 638 amino acids, has 3 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type


This is Chaperone protein DnaJ protein, from Ehrlichia ruminantium (strain Welgevonden), contains 382 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Membrane-associated protein TcaA protein, from Staphylococcus aureus (strain COL), contains 460 amino acids, has 1 C4-type Zinc finger.

Plays a major role in decreasing resistance to glycopeptide antibiotics, Overexpression confers oxacillin hypersusceptibility, without affecting the levels of resistance towards vancomycin, Could be involved in virulence, Overexpression increases the levels of teicoplanin susceptibility, Overexpression also increased susceptibility to oxacillin in methicillin-resistant strains


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Staphylococcus aureus (strain COL), contains 285 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Staphylococcus aureus (strain COL), contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type


This is DNA primase protein, from Staphylococcus aureus (strain COL), contains 599 amino acids, has 1 CHC2-type Zinc finger.

RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication


This is UvrABC system protein A protein, from Staphylococcus aureus (strain COL), contains 948 amino acids, has 2 C4-type Zinc finger.

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate

Belongs to the ABC transporter superfamily, UvrA family


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Staphylococcus epidermidis (strain ATCC 35984 / RP62A), contains 285 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Staphylococcus epidermidis (strain ATCC 35984 / RP62A), contains 373 amino acids, has 1 CR-type Zinc finger.

CR-type


This is DNA primase protein, from Staphylococcus epidermidis (strain ATCC 35984 / RP62A), contains 598 amino acids, has 1 CHC2-type Zinc finger.


This is UvrABC system protein A protein, from Staphylococcus epidermidis (strain ATCC 35984 / RP62A), contains 944 amino acids, has 2 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Campylobacter jejuni (strain RM1221), contains 373 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Zinc finger protein 766 protein, from Human, contains 468 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 8 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 667 protein, from Human, contains 610 amino acids, has 14 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 5; degenerate


This is Zinc finger CCHC domain-containing protein 12 protein, from Rat, contains 401 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway, It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex, It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)


This is PHD finger protein 23A protein, from African clawed frog, contains 272 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Acts as a negative regulator of autophagy


This is Methionine aminopeptidase 1 protein, from Western clawed frog, contains 385 amino acids, has 1 C6H2-type Zinc finger.

Cotranslationally removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

Belongs to the peptidase M24A family, Methionine aminopeptidase type 1 subfamily


This is Opioid-binding protein/cell adhesion molecule protein, from Chimpanzee, contains 345 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Binds opioids in the presence of acidic lipids; probably involved in cell contact


This is Large ribosomal subunit protein eL24 protein, from Pyrococcus kodakaraensis (strain KOD1), contains 67 amino acids, has 1 C4-type Zinc finger.

Belongs to the eukaryotic ribosomal protein eL24 family


This is Zinc finger protein 311 protein, from Human, contains 666 amino acids, has 14 C2H2-type Zinc finger.


This is Zinc finger protein 484 protein, from Human, contains 852 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger, has 15 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 3; degenerate

C2H2-type 4; degenerate


This is Zinc finger protein 506 protein, from Human, contains 444 amino acids, has 8 C2H2-type Zinc finger.


This is U1 small nuclear ribonucleoprotein C protein, from Filobasidiella neoformans, contains 220 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Geobacillus kaustophilus (strain HTA426), contains 290 amino acids, has 1 C4-type Zinc finger.


This is Formamidopyrimidine-DNA glycosylase protein, from Geobacillus kaustophilus (strain HTA426), contains 274 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Chaperone protein DnaJ protein, from Geobacillus kaustophilus (strain HTA426), contains 382 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Chlamydophila abortus, contains 391 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow), contains 394 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Silicibacter pomeroyi, contains 381 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Silicibacter pomeroyi, contains 283 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Formamidopyrimidine-DNA glycosylase protein, from Streptococcus thermophilus (strain CNRZ 1066), contains 273 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Streptococcus thermophilus (strain CNRZ 1066), contains 288 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Streptococcus thermophilus (strain CNRZ 1066), contains 377 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311), contains 273 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311), contains 288 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311), contains 377 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Optineurin protein, from African clawed frog, contains 532 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, May act by regulating membrane trafficking and cellular morphogenesis


This is V-set and transmembrane domain-containing protein 5 protein, from Rat, contains 199 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics, Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia, In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution, Promotes formation of unstable neuronal spines such as thin and branched types, Regulates neuronal morphogenesis and migration during cortical development in the brain


This is E3 ubiquitin-protein ligase NEURL3 protein, from Rat, contains 254 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity, Seems to utilize UBE2E1, Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7, Inhibits also hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2


This is Fas apoptotic inhibitory molecule 3 protein, from Rat, contains 426 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

May play a role in the immune system processes, Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL, Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream, May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity)


This is Zinc finger C3HC-type protein 1-like protein, from Western clawed frog, contains 478 amino acids, has 1 C3HC-type Zinc finger.

Probable component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1)


This is Zinc finger protein 569 protein, from Human, contains 686 amino acids, has 18 C2H2-type Zinc finger.


This is Beta-2-microglobulin protein, from Cat, contains 118 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system (By similarity)

Belongs to the beta-2-microglobulin family


This is Protein M2-1 protein, from MPV, contains 176 amino acids, has 1 C3H1-type Zinc finger.

Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription, Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription, Preferentially binds to poly(A)-rich sequences, Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding

Belongs to the pneumoviridae M2-1 protein family


This is Zinc finger protein 667 protein, from Rat, contains 608 amino acids, has 14 C2H2-type Zinc finger.


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Anacystis nidulans, contains 305 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Chaperone protein DnaJ protein, from Anacystis nidulans, contains 376 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Chaperone protein DnaJ protein, from Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4), contains 374 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4), contains 274 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Intercellular adhesion molecule 4 protein, from Chimpanzee, contains 269 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins (By similarity)

Belongs to the immunoglobulin superfamily, ICAM family


This is Intercellular adhesion molecule 3 protein, from Chimpanzee, contains 547 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), ICAM3 is also a ligand for integrin alpha-D/beta-2, In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages


This is Intercellular adhesion molecule 2 protein, from Western lowland gorilla, contains 275 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion, It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity)


This is Intercellular adhesion molecule 2 protein, from Chimpanzee, contains 275 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is Intercellular adhesion molecule 1 protein, from Pygmy chimpanzee, contains 532 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity)


This is Intercellular adhesion molecule 1 protein, from Rhesus macaque, contains 532 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Chaperone protein DnaJ protein, from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4), contains 375 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ protein, from Burkholderia multivorans (strain ATCC 17616 / 249), contains 376 amino acids, has 1 CR-type Zinc finger.

CR-type


This is E3 ubiquitin-protein ligase makorin-2 protein, from Japanese pufferfish, contains 402 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity), Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway, Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression


This is Probable E3 ubiquitin-protein ligase makorin-1 protein, from Japanese pufferfish, contains 429 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins


This is Chaperone protein DnaJ 2 protein, from Azoarcus sp. (strain EbN1), contains 376 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Chaperone protein DnaJ 1 protein, from Azoarcus sp. (strain EbN1), contains 347 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Azoarcus sp. (strain EbN1), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Chaperone protein DnaJ protein, from Anaplasma marginale (strain St. Maries), contains 379 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Salmonella paratyphi A (strain ATCC 9150 / SARB42), contains 269 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Endonuclease 8 protein, from Salmonella paratyphi A (strain ATCC 9150 / SARB42), contains 263 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Salmonella paratyphi A (strain ATCC 9150 / SARB42), contains 304 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Salmonella paratyphi A (strain ATCC 9150 / SARB42), contains 375 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Zinc finger CCCH-type with G patch domain-containing protein protein, from Rat, contains 507 amino acids, has 1 C3H1-type Zinc finger.

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence, Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters, Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration, Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity)


This is E3 ubiquitin-protein ligase RNF170 protein, from African clawed frog, contains 257 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor (ITPR) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway, Also involved in ITPR turnover in resting cells


This is Receptor-transporting protein 3 protein, from Mouse, contains 474 amino acids, has 1 3CxxC-type Zinc finger.

Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43


This is Forkhead box protein P2 protein, from Lar gibbon, contains 713 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium, May also play a role in developing neural, gastrointestinal and cardiovascular tissues, Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential, Plays a role in synapse formation by regulating SRPX2 levels (By similarity)


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR), contains 292 amino acids, has 1 C4-type Zinc finger.


This is Chaperone protein DnaJ protein, from Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR), contains 384 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Formamidopyrimidine-DNA glycosylase protein, from Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR), contains 270 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is T-cell surface glycoprotein CD3 epsilon chain protein, from Cat, contains 202 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways, In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development, Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E, Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region


This is Neuronal growth regulator 1 protein, from Sumatran orangutan, contains 354 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May be involved in cell-adhesion, May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity)


This is Muscleblind-like protein 2 protein, from Sumatran orangutan, contains 373 amino acids, has 4 C3H1-type Zinc finger.

Mediates pre-mRNA alternative splicing regulation, Acts either as activator or repressor of splicing on specific pre-mRNA targets, Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle, Antagonizes the alternative splicing activity pattern of CELF proteins, RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3, Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs, Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques, May play a role in myotonic dystrophy pathophysiology (DM) (By similarity)


This is 5'-3' exoribonuclease 2 protein, from Sumatran orangutan, contains 950 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Possesses 5'->3' exoribonuclease activity, May promote the termination of transcription by RNA polymerase II, During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase, The processive degradation of this 3' fragment by this protein may promote termination of transcription, Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity)

Belongs to the 5'-3' exonuclease family, XRN2/RAT1 subfamily


This is Zinc finger protein 574 protein, from Sumatran orangutan, contains 895 amino acids, has 19 C2H2-type Zinc finger, has 1 C2H2-type 15; degenerate Zinc finger.

C2H2-type 15; degenerate

May be involved in transcriptional regulation


This is Eukaryotic translation initiation factor 2 subunit 2 protein, from Sumatran orangutan, contains 333 amino acids, has 1 C4-type Zinc finger.

Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC), Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex, In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B


This is Tax1-binding protein 1 homolog protein, from Sumatran orangutan, contains 813 amino acids, has 2 UBZ1-type Zinc finger.

Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation, Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates, Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production, Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways, Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling, As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis, Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation


This is Zinc finger protein 346 protein, from Sumatran orangutan, contains 310 amino acids, has 4 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

Matrin-type

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity


This is Zinc finger Ran-binding domain-containing protein 2 protein, from Sumatran orangutan, contains 320 amino acids, has 2 RanBP2-type Zinc finger.

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts, May interfere with constitutive 5'-splice site selection (By similarity)


This is PR domain zinc finger protein 4 protein, from Sumatran orangutan, contains 801 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 4 C2H2-type Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 1; atypical

C2H2-type 6; atypical

May function as a transcription factor involved in cell differentiation


This is CCHC-type zinc finger nucleic acid binding protein protein, from Sumatran orangutan, contains 177 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity), Has a role as transactivator of the Myc promoter (By similarity), Binds single-stranded RNA in a sequence-specific manner (By similarity), Binds G-rich elements in target mRNA coding sequences (By similarity), Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity)


This is Zinc finger protein 540 protein, from Sumatran orangutan, contains 660 amino acids, has 17 C2H2-type Zinc finger.


This is TRMT1-like protein protein, from Sumatran orangutan, contains 733 amino acids, has 1 C2H2-type Zinc finger.

May play a role in motor coordination and exploratory behavior

Belongs to the class I-like SAM-binding methyltransferase superfamily, Trm1 family


This is FYVE, RhoGEF and PH domain-containing protein 3 protein, from Sumatran orangutan, contains 737 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Promotes the formation of filopodia, May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)


This is SET and MYND domain-containing protein 4 protein, from Sumatran orangutan, contains 804 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a critical role in cardiac development (By similarity), Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity)


This is Nuclear receptor subfamily 4 group A member 2 protein, from Sumatran orangutan, contains 598 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development, It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)

Belongs to the nuclear hormone receptor family


This is Zinc finger protein 436 protein, from Sumatran orangutan, contains 470 amino acids, has 11 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate


This is Telomere zinc finger-associated protein protein, from Sumatran orangutan, contains 688 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Telomere-binding protein that acts as a regulator of telomere length, Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat, Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres, Also acts as a transcription regulator that binds to promoter regions, Regulates expression of a small subset of genes, including MTFP1, Regulates expression the J and/or S elements in MHC II promoter, Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A


This is Zinc finger protein with KRAB and SCAN domains 1 protein, from Sumatran orangutan, contains 563 amino acids, has 6 C2H2-type Zinc finger.


This is Zinc finger protein 512 protein, from Sumatran orangutan, contains 567 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 3; atypical


This is Lethal(3)malignant brain tumor-like protein 2 protein, from Sumatran orangutan, contains 705 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Putative Polycomb group (PcG) protein, PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility, Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis, Binds to monomethylated and dimethylated 'Lys-20' on histone H4, Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity)


This is Zinc finger protein 394 protein, from Sumatran orangutan, contains 574 amino acids, has 7 C2H2-type Zinc finger.


This is High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor protein, from Sumatran orangutan, contains 544 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Functions as a receptor for the Fc fragment of IgA and IgM, Binds IgA and IgM with high affinity and mediates their endocytosis, May function in the immune response to microbes mediated by IgA and IgM (By similarity)


This is Zinc finger protein 148 protein, from Sumatran orangutan, contains 794 amino acids, has 4 C2H2-type Zinc finger.

Involved in transcriptional regulation, Represses the transcription of a number of genes including gastrin, stromelysin and enolase, Binds to the G-rich box in the enhancer region of these genes (By similarity)


This is ADP-ribosylation factor GTPase-activating protein 3 protein, from Sumatran orangutan, contains 516 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)


This is Zinc finger CCHC domain-containing protein 8 protein, from Sumatran orangutan, contains 704 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs, NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation, May be involved in pre-mRNA splicing, It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function


This is Zinc fingers and homeoboxes protein 2 protein, from Sumatran orangutan, contains 837 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor, Represses the promoter activity of the CDC25C gene stimulated by NFYA, May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells, In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex


This is Amphoterin-induced protein 2 protein, from Sumatran orangutan, contains 522 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Required for depolarization-dependent survival of cultured cerebellar granule neurons, May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3, May contribute to signal transduction through its intracellular domain (By similarity)

Belongs to the immunoglobulin superfamily, AMIGO family


This is CXXC-type zinc finger protein 5 protein, from Sumatran orangutan, contains 322 amino acids, has 1 CXXC-type Zinc finger.

CXXC-type

May indirectly participate in activation of the NF-kappa-B and MAPK pathways, Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells, Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest, Involved in myelopoiesis (By similarity), Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen), May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity), Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)


This is AN1-type zinc finger protein 6 protein, from Sumatran orangutan, contains 208 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger.

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis, Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1, Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6, In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)


This is Metal-response element-binding transcription factor 2 protein, from Sumatran orangutan, contains 593 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (By similarity), Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation, Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells, Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex, In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally, Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity)


This is Butyrophilin subfamily 2 member A2 protein, from Sumatran orangutan, contains 528 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Myelin protein zero-like protein 2 protein, from Sumatran orangutan, contains 214 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Anaphase-promoting complex subunit 11 protein, from Sumatran orangutan, contains 84 amino acids, has 1 RING-type Zinc finger.

RING-type

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity)


This is Tapasin-related protein protein, from Sumatran orangutan, contains 468 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M, Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC), Expression seems to slow down and down-regulate MHC class I surface expression


This is General transcription factor IIE subunit 1 protein, from Sumatran orangutan, contains 439 amino acids, has 1 C4-type Zinc finger.

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH, Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity)

Belongs to the TFIIE alpha subunit family


This is BUB3-interacting and GLEBS motif-containing protein ZNF207 protein, from Sumatran orangutan, contains 494 amino acids, has 2 C2H2-type Zinc finger.

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly, ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets, Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks, Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3, Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3, According to another report, the stabilization is independent of the proteasome


This is Polycomb complex protein BMI-1 protein, from Sumatran orangutan, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A, In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2


This is Zinc finger C3HC-type protein 1 protein, from Sumatran orangutan, contains 502 amino acids, has 1 C3HC-type Zinc finger.

Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1), Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase, Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity)


This is Myelin-oligodendrocyte glycoprotein protein, from Sumatran orangutan, contains 246 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Minor component of the myelin sheath, May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication, Mediates homophilic cell-cell adhesion (By similarity)


This is Cyclic AMP-dependent transcription factor ATF-7 protein, from Sumatran orangutan, contains 483 amino acids, has 1 C2H2-type Zinc finger.

Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (By similarity), In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes, Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity), In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (By similarity), Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity)


This is Zinc finger protein 330 protein, from Sumatran orangutan, contains 320 amino acids, has 4 C4-type Zinc finger.


This is Protein ZNF365 protein, from Sumatran orangutan, contains 407 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Involved in the regulation of neurogenesis, Negatively regulates neurite outgrowth (By similarity), Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis, Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth, Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity), Involved in homologous recombination (HR) repair pathway, Required for proper resolution of DNA double-strand breaks (DSBs) by HR, Is required for recovery of stalled replication forks, and directly contributes to genomic stability, Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery, Contributes to genomic stability by preventing telomere dysfunction (By similarity)

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome


This is Zinc finger protein 182 protein, from Sumatran orangutan, contains 620 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein Pegasus protein, from Sumatran orangutan, contains 420 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 4; degenerate

Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity), Involved in megakaryocyte differentiation (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Zinc finger protein 24 protein, from Sumatran orangutan, contains 368 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor required for myelination of differentiated oligodendrocytes, Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state, In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle, Specifically binds to the 5'-TCAT-3' DNA sequence, Has transcription repressor activity in vitro (By similarity)


This is OX-2 membrane glycoprotein protein, from Sumatran orangutan, contains 269 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Costimulates T-cell proliferation, May regulate myeloid cell activity in a variety of tissues (By similarity)


This is Target of EGR1 protein 1 protein, from Sumatran orangutan, contains 510 amino acids, has 1 C3H1-type Zinc finger.

Inhibits cell growth rate and cell cycle, Induces CDKN1A expression as well as TGF-beta expression, Mediates the inhibitory growth effect of EGR1, Involved in the maturation of snRNAs and snRNA 3'-tail processing


This is ADP-ribosylation factor GTPase-activating protein 2 protein, from Sumatran orangutan, contains 521 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum, Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)


This is Zinc finger protein 131 protein, from Sumatran orangutan, contains 589 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling, Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity)


This is Non-structural maintenance of chromosomes element 1 homolog protein, from Sumatran orangutan, contains 266 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate, Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex, Involved in maintenance of genome integrity, DNA damage response and DNA repair, NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair


This is Zinc finger protein 585B protein, from Sumatran orangutan, contains 769 amino acids, has 21 C2H2-type Zinc finger.


This is Nucleoporin NUP42 protein, from Sumatran orangutan, contains 423 amino acids, has 1 C3H1-type Zinc finger.

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm


This is Inhibitor of growth protein 3 protein, from Sumatran orangutan, contains 403 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair, NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage, Component of a SWR1-like complex that specifically mediates the removal of histone H2A,Z/H2AZ1 from the nucleosome (By similarity)


This is RNA-binding protein NOB1 protein, from Sumatran orangutan, contains 411 amino acids, has 1 NOB1 Zinc finger.

May play a role in mRNA degradation (By similarity), Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity)


This is Methionine aminopeptidase 1 protein, from Sumatran orangutan, contains 386 amino acids, has 1 C6H2-type Zinc finger.

Cotranslationally removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)


This is E3 ubiquitin-protein ligase TRIM35 protein, from Sumatran orangutan, contains 492 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response, Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway, Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2, Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling, Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway, Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth


This is Small ribosomal subunit protein eS27 protein, from Sumatran orangutan, contains 84 amino acids, has 1 C4-type Zinc finger.

Component of the small ribosomal subunit, The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, Required for proper rRNA processing and maturation of 18S rRNAs, Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Belongs to the eukaryotic ribosomal protein eS27 family


This is Transcriptional adapter 2-beta protein, from Sumatran orangutan, contains 420 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2


This is Zinc finger protein 7 protein, from Sumatran orangutan, contains 686 amino acids, has 15 C2H2-type Zinc finger.


This is Zinc finger protein 2 protein, from Sumatran orangutan, contains 425 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 9; degenerate


This is Zinc finger protein 1 homolog protein, from Sumatran orangutan, contains 407 amino acids, has 8 C2H2-type Zinc finger.


This is DBIRD complex subunit ZNF326 protein, from Sumatran orangutan, contains 579 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions, May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro (By similarity)


This is Zinc finger and SCAN domain-containing protein 2 protein, from Sumatran orangutan, contains 645 amino acids, has 14 C2H2-type Zinc finger.

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis


This is THAP domain-containing protein 1 protein, from Sumatran orangutan, contains 213 amino acids, has 1 THAP-type Zinc finger.

THAP-type

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression, Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1, Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1, May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity)


This is Integrator complex subunit 12 protein, from Sumatran orangutan, contains 462 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing, The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes, Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex

Belongs to the Integrator subunit 12 family


This is Nuclear receptor subfamily 2 group C member 1 protein, from Sumatran orangutan, contains 601 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism, Primarily repressor of a broad range of genes including ESR1 and RARB, Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, Also activator of OCT4 gene expression, Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation, Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Calcium-binding and coiled-coil domain-containing protein 1 protein, from Sumatran orangutan, contains 691 amino acids, has 1 UBZ1-type Zinc finger.

Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG), Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth (By similarity)


This is ORC ubiquitin ligase 1 protein, from Sumatran orangutan, contains 726 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin ligase essential for DNA replication origin activation during S phase, Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase


This is Triggering receptor expressed on myeloid cells 1 protein, from Sumatran orangutan, contains 231 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses, Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12, In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma, This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections, By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis


This is Juxtaposed with another zinc finger protein 1 protein, from Sumatran orangutan, contains 243 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2, Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity, Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD, Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue, Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity


This is Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 protein, from Sumatran orangutan, contains 614 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors, Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination, Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)


This is Zinc finger protein 181 protein, from Sumatran orangutan, contains 615 amino acids, has 11 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Probable E3 ubiquitin-protein ligase DTX3 protein, from Sumatran orangutan, contains 347 amino acids, has 1 RING-type Zinc finger.

RING-type

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context, Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity


This is Tripartite motif-containing protein 54 protein, from Sumatran orangutan, contains 358 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

May bind and stabilize microtubules during myotubes formation


This is Leukocyte surface antigen CD47 protein, from Sumatran orangutan, contains 323 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Adhesive protein that mediates cell-to-cell interactions, Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins, Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation, Plays a role in modulating pulmonary endothelin EDN1 signaling (By similarity), Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity), Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity), Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells, Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity), Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity), Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (By similarity), In response to THBS1, negatively modulates wound healing, Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity), May play a role in membrane transport and/or integrin dependent signal transduction (By similarity), May prevent premature elimination of red blood cells (By similarity)


This is Interleukin-11 receptor subunit alpha protein, from Sumatran orangutan, contains 422 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity, The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Box C/D snoRNA protein 1 protein, from Sumatran orangutan, contains 465 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis


This is Zinc finger FYVE domain-containing protein 1 protein, from Sumatran orangutan, contains 789 amino acids, has 2 FYVE-type Zinc finger.

FYVE-type

FYVE-type

Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity), Regulates the morphology, size and distribution of LDs (By similarity), Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity), Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity)


This is Zinc finger and SCAN domain-containing protein 26 protein, from Mouse, contains 466 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 7 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Protein SREK1IP1 protein, from Rat, contains 153 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Possible splicing regulator involved in the control of cellular survival


This is Zinc finger protein 467 protein, from Rat, contains 594 amino acids, has 12 C2H2-type Zinc finger.

Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow, Enhances the osteoclast-supporting ability of stromal cells, Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE), Transactivates several promoters including FOS, OSM and PPARG, Recruits a histone deacetylase complex (By similarity)


This is Polycomb complex protein BMI-1 protein, from Chicken, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2


This is Alpha-aminoadipate carrier protein LysW protein, from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8), contains 54 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

Carrier protein that bears the covalently bound substrates for lysine biosynthesis; the bound alpha-aminoadipate (AAA) is sequentially converted to L-lysine


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta protein, from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8), contains 285 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Chaperone protein DnaJ 1 protein, from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8), contains 350 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Zinc finger CCHC-type and RNA-binding motif-containing protein 1 protein, from Zebrafish, contains 218 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is RING finger protein 215 protein, from Mouse, contains 379 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Zinc finger and BTB domain-containing protein 41 protein, from Human, contains 909 amino acids, has 14 C2H2-type Zinc finger.


This is Zinc finger protein 678 protein, from Human, contains 525 amino acids, has 14 C2H2-type Zinc finger, has 1 C2H2-type 15; degenerate Zinc finger.

C2H2-type 15; degenerate


This is Zinc finger protein 362 protein, from Human, contains 420 amino acids, has 6 C2H2-type Zinc finger.


This is Zinc finger protein 684 protein, from Human, contains 378 amino acids, has 8 C2H2-type Zinc finger.


This is Zinc finger protein 697 protein, from Human, contains 545 amino acids, has 11 C2H2-type Zinc finger.


This is Zinc finger C2HC domain-containing protein 1B protein, from Human, contains 222 amino acids, has 1 C2HC-type Zinc finger.