This is Formamidopyrimidine-DNA glycosylase protein, from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711), contains 276 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is DNA damage-binding protein 2 protein, from Rice, contains 584 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for DNA repair, Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex), The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable), May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity)

Belongs to the WD repeat DDB2/WDR76 family


This is Probable E3 ubiquitin-protein ligase ARI15 protein, from Mouse-ear cress, contains 452 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger, has 1 RanBP2-type Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates

Belongs to the RBR family, Ariadne subfamily


This is Probable E3 ubiquitin-protein ligase ARI7 protein, from Mouse-ear cress, contains 562 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical


This is Probable E3 ubiquitin-protein ligase ARI2 protein, from Mouse-ear cress, contains 593 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical


This is Protein FRIGIDA-ESSENTIAL 1 protein, from Mouse-ear cress, contains 587 amino acids, has 1 C3H1-type Zinc finger.

Transcriptional activator involved in the FRIGIDA-mediated vernalization pathway, but not in the autonomous flowering pathway, Acts cooperatively with FRI (FRIGIDA) or FRL1 (FRIGIDA-LIKE 1) to promote FLC (FLOWERING LOCUS C) expression, Required for the stabilization of the FRI-C complex


This is CAX-interacting protein 4 protein, from Mouse-ear cress, contains 332 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Maidenhair fern, contains 310 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Optineurin protein, from Rhesus macaque, contains 571 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8, Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation, Negatively regulates the induction of IFNB in response to RNA virus infection, Plays a neuroprotective role in the eye and optic nerve, Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52


This is Sodium channel subunit beta-2 protein, from Dog, contains 215 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel, The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli, Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)

Belongs to the sodium channel auxiliary subunit SCN2B (TC 8,A,17) family


This is E3 ubiquitin-protein ligase sina protein, from Blood fluke, contains 371 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates the ubiquitin-mediated degradation of nuclear receptors for retinoids SmRXR1 and SmRXR2

Belongs to the SINA (Seven in absentia) family


This is Fibroblast growth factor receptor protein, from Hydra, contains 816 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for basic fibroblast growth factor

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Zygote arrest protein 1 protein, from Human, contains 424 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes, MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth, Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs, Binds to the 3'-UTR of maternal mRNAs, Maternal mRNAs stored in the MARDO are translationally repressed, Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is Zinc finger protein 554 protein, from Human, contains 538 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 7 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein 546 protein, from Human, contains 836 amino acids, has 22 C2H2-type Zinc finger.


This is Hyaluronan and proteoglycan link protein 4 protein, from Human, contains 402 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (By similarity), Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons (By similarity)

Secreted, extracellular space, extracellular matrix


This is V-set and immunoglobulin domain-containing protein 10-like protein, from Human, contains 867 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is Zinc finger and SCAN domain-containing protein 30 protein, from Human, contains 494 amino acids, has 7 C2H2-type Zinc finger.


This is Amphoterin-induced protein 3 protein, from Human, contains 504 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May mediate heterophilic cell-cell interaction, May contribute to signal transduction through its intracellular domain (By similarity)

Belongs to the immunoglobulin superfamily, AMIGO family


This is Zinc finger protein 354C protein, from Human, contains 554 amino acids, has 11 C2H2-type Zinc finger.

May function as a transcription repressor, Binds to 5'-CCACA-3' core sequence, Suppresses osteogenic effects of RUNX2, May be involved in osteoblastic differentiation (By similarity), Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)


This is Zinc finger protein 573 protein, from Human, contains 665 amino acids, has 19 C2H2-type Zinc finger.


This is Zinc finger protein 280B protein, from Human, contains 543 amino acids, has 4 C2H2-type Zinc finger.


This is RING finger protein Z protein, from TCRV, contains 95 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a crucial role in virion assembly and budding, Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L, Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP, Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway, The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z, Also selectively represses protein production by associating with host eIF4E

Belongs to the arenaviridae Z protein family


This is Gag polyprotein protein, from WDSV, contains 582 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Plays a role in budding and is processed by the viral protease during virion maturation outside the cell


This is Protein OPG185 protein, from VACV, contains 315 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Prevents cell to cell fusion by interacting with and directing the viral OPG040 protein on the host plasma membrane, The OPG185-OPG040 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation, Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack

Belongs to the orthopoxvirus OPG185 family


This is Envelope glycoprotein C protein, from HHV-2, contains 480 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate (By similarity), Also plays a role in host immune evasion by inhibiting the host complement cascade activation

Belongs to the herpesviridae glycoprotein C family


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha protein, from Clostridium tetani (strain Massachusetts / E88), contains 575 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity)

In the C-terminal section; belongs to the AccA family


This is Formamidopyrimidine-DNA glycosylase protein, from Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110), contains 293 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Zinc finger protein 346 protein, from African clawed frog, contains 524 amino acids, has 7 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

Matrin-type

Matrin-type

Matrin-type

Matrin-type

Binds preferentially to dsRNA, but also to RNA-DNA hybrids


This is E3 ubiquitin-protein ligase RNF128 protein, from African clawed frog, contains 404 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains (By similarity), Converts epidermis into cement gland and neural tissue in whole embryos


This is Mast/stem cell growth factor receptor Kit protein, from Japanese pufferfish, contains 984 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Progesterone receptor protein, from Dybovsky's frog, contains 711 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Zinc finger protein with KRAB and SCAN domains 1 protein, from Mouse, contains 561 amino acids, has 6 C2H2-type Zinc finger.


This is Pre-mRNA-splicing factor RBM22 protein, from Mouse, contains 420 amino acids, has 1 C3H1-type Zinc finger.

Required for pre-mRNA splicing as component of the activated spliceosome, Involved in the first step of pre-mRNA splicing, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle, Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses


This is Zinc finger CCCH domain-containing protein 14 protein, from Mouse, contains 735 amino acids, has 5 C3H1-type Zinc finger.

Involved in poly(A) tail length control in neuronal cells, Binds the polyadenosine RNA oligonucleotides


This is F-box only protein 30 protein, from Mouse, contains 746 amino acids, has 1 TRAF-type Zinc finger.

TRAF-type

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, Required for muscle atrophy following denervation


This is rRNA N6-adenosine-methyltransferase ZCCHC4 protein, from Mouse, contains 512 amino acids, has 1 GRF-type Zinc finger, has 1 CCHC-type Zinc finger.

GRF-type

CCHC-type

rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA, N6-methylation of adenine(4220) in 28S rRNA is required for translation


This is Transcription factor Sp8 protein, from Mouse, contains 486 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor which plays a key role in limb development, Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Zinc finger protein 76 protein, from Mouse, contains 568 amino acids, has 7 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein 436 protein, from Mouse, contains 452 amino acids, has 12 C2H2-type Zinc finger.


This is Immunoglobulin superfamily DCC subclass member 3 protein, from Mouse, contains 813 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, DCC family


This is Cleavage and polyadenylation specificity factor subunit 4 protein, from Mouse, contains 211 amino acids, has 3 C3H1-type Zinc finger, has 1 CCHC-type Zinc finger.

CCHC-type

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition, CPSF4 binds RNA polymers with a preference for poly(U) (By similarity)


This is E3 ubiquitin-protein ligase MARCHF3 protein, from Mouse, contains 218 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is PHD finger protein 23 protein, from Mouse, contains 401 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria


This is Zinc finger protein Pegasus protein, from Mouse, contains 419 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity), Involved in megakaryocyte differentiation (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is WD repeat and FYVE domain-containing protein 2 protein, from Mouse, contains 400 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (By similarity), Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859), Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (PubMed:20189988), Participates in transferrin receptor endocytosis (By similarity)


This is E3 ubiquitin-protein ligase RNF26 protein, from Mouse, contains 424 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud, Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1, Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport, Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING, Also required to limit type I interferon response by promoting autophagic degradation of IRF3


This is Probable E3 ubiquitin-protein ligase TRIML1 protein, from Mouse, contains 470 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development, Involved in progression of blastocyst stage and subsequent embryo development


This is RING finger and SPRY domain-containing protein 1 protein, from Mouse, contains 576 amino acids, has 1 RING-type Zinc finger.

RING-type


This is RNA-binding protein NOB1 protein, from Mouse, contains 403 amino acids, has 1 NOB1 Zinc finger.

May play a role in mRNA degradation (By similarity), Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity)


This is Structure-specific endonuclease subunit SLX1 protein, from Mouse, contains 270 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA, Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs), Resolves HJs by generating two pairs of ligatable, nicked duplex products


This is Protein mono-ADP-ribosyltransferase PARP12 protein, from Mouse, contains 711 amino acids, has 5 C3H1-type Zinc finger.

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins


This is Muscleblind-like protein 2 protein, from Mouse, contains 373 amino acids, has 4 C3H1-type Zinc finger.

Mediates pre-mRNA alternative splicing regulation, Acts either as activator or repressor of splicing on specific pre-mRNA targets, Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle, Antagonizes the alternative splicing activity pattern of CELF proteins, RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3, Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs, Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques, May play a role in myotonic dystrophy pathophysiology (DM) (By similarity)


This is Amphoterin-induced protein 3 protein, from Mouse, contains 508 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May mediate heterophilic cell-cell interaction, May contribute to signal transduction through its intracellular domain (By similarity)


This is Natural cytotoxicity triggering receptor 1 protein, from Mouse, contains 325 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis

Belongs to the natural cytotoxicity receptor (NCR) family


This is Zinc finger protein 62 protein, from Mouse, contains 914 amino acids, has 26 C2H2-type Zinc finger.

May play a role in differentiating skeletal muscle


This is Receptor-transporting protein 1 protein, from Mouse, contains 263 amino acids, has 1 3CxxC-type Zinc finger.

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs


This is Zinc finger protein ZXDC protein, from Mouse, contains 858 amino acids, has 10 C2H2-type Zinc finger.

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes


This is E3 ubiquitin-protein ligase MARCHF11 protein, from Mouse, contains 400 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, May play a role in ubuquitin-dependent protein sorting in developmenting spermatids


This is Zinc finger protein 276 protein, from Mouse, contains 614 amino acids, has 5 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Natural cytotoxicity triggering receptor 3 protein, from Rat, contains 192 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1, Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands, It controls, for instance, NK cells cytotoxicity against tumor cells, Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation


This is Transcription factor IIIB 90 kDa subunit protein, from Mouse, contains 676 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters


This is Polyhomeotic-like protein 3 protein, from Mouse, contains 981 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity)


This is THAP domain-containing protein 1 protein, from Mouse, contains 210 amino acids, has 1 THAP-type Zinc finger.

THAP-type

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression, Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1, Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1, May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity)


This is FLYWCH-type zinc finger-containing protein 1 protein, from Mouse, contains 673 amino acids, has 5 FLYWCH-type Zinc finger.

FLYWCH-type

FLYWCH-type

FLYWCH-type

FLYWCH-type

FLYWCH-type

Transcription cofactor, Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding, May play a role in DNA-damage response signaling, Binds specifically to DNA sequences at peri-centromeric chromatin loci


This is Nucleoporin NUP42 protein, from Mouse, contains 420 amino acids, has 1 C3H1-type Zinc finger.

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm


This is Zinc finger MIZ domain-containing protein 2 protein, from Mouse, contains 920 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors


This is DNA topoisomerase 1 protein, from Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200), contains 689 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is Formamidopyrimidine-DNA glycosylase protein, from Streptococcus pneumoniae (strain ATCC BAA-255 / R6), contains 274 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Formamidopyrimidine-DNA glycosylase protein, from Shewanella oneidensis (strain MR-1), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is FCS-Like Zinc finger 13 protein, from Mouse-ear cress, contains 222 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is NEP1-interacting protein 2 protein, from Mouse-ear cress, contains 241 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Intrinsic thylakoid membrane protein that fixes RPOT2 on the stromal side of the thylakoid membrane

Belongs to the RING-type zinc finger family, NIP subfamily


This is E3 ubiquitin protein ligase RIE1 protein, from Mouse-ear cress, contains 359 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable E3 ubiquitin-protein ligase required for embryo development


This is E3 ubiquitin-protein ligase SIS3 protein, from Mouse-ear cress, contains 358 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin protein ligase that acts as positive regulator of sugar signaling during early seedling development, Possesses E3 ligase activity in vitro


This is FCS-Like Zinc finger 14 protein, from Mouse-ear cress, contains 248 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type


This is Cytoplasmic 60S subunit biogenesis factor REI1 homolog 1 protein, from Mouse-ear cress, contains 404 amino acids, has 4 C2H2-type Zinc finger.

Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit, Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity), Can complement the growth defect of a yeast mutant lacking REI1 (PubMed:24038679), Required for leaf growth under cold temperature conditions (PubMed:24038679)


This is E3 ubiquitin-protein ligase RNF220 protein, from Crab-eating macaque, contains 566 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity), Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity), Plays a critical role in the regulation of nuclear lamina


This is Peroxisome biogenesis factor 10 protein, from Crab-eating macaque, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is Seven in absentia homolog 3 protein, from Human, contains 269 amino acids, has 1 SIAH-type; degenerate Zinc finger.

SIAH-type; degenerate

Negative regulator of PRKN translocation to damaged mitochondria, Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria


This is Zinc finger protein 695 protein, from Human, contains 515 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger, has 9 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; degenerate

C2H2-type 3; atypical

C2H2-type 4; degenerate

May be involved in transcriptional regulation


This is Zinc finger CCCH domain-containing protein 7A protein, from Human, contains 971 amino acids, has 3 C3H1-type Zinc finger, has 1 C2H2-type Zinc finger.

May be a specific regulator of miRNA biogenesis, Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop


This is Zinc finger and SCAN domain-containing protein 29 protein, from Human, contains 852 amino acids, has 6 C2H2-type Zinc finger.


This is Transcription factor Sp8 protein, from Human, contains 490 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor which plays a key role in limb development, Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity)


This is Probable tRNA (uracil-O(2)-)-methyltransferase protein, from Human, contains 757 amino acids, has 1 C3H1-type Zinc finger.

Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase


This is Zinc finger protein 679 protein, from Human, contains 411 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 7 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate


This is Zinc finger protein 34 protein, from Human, contains 560 amino acids, has 12 C2H2-type Zinc finger.


This is U1 small nuclear ribonucleoprotein C protein, from Zebrafish, contains 159 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region

Belongs to the U1 small nuclear ribonucleoprotein C family


This is Protein lin-28 homolog A protein, from African clawed frog, contains 195 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism, Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity), 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis, Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization, Suppressor of microRNA (miRNA) biogenesis, including that of let-7, Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase, This results in the terminal uridylation of target pre-miRNAs, Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity), Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins, Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation, Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity)


This is Polycomb complex protein BMI-1-A protein, from Zebrafish, contains 320 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2


This is Zinc finger protein ZIC 1 protein, from Chicken, contains 444 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Acts as a transcriptional activator, Involved in neurogenesis, Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum, Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity)

Belongs to the GLI C2H2-type zinc-finger protein family


This is CXADR-like membrane protein protein, from Rat, contains 372 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be involved in the cell-cell adhesion, May play a role in adipocyte differentiation and development of obesity, Is required for normal small intestine development (By similarity)


This is Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 protein, from Mouse, contains 740 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface, Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity)


This is Zinc finger protein 668 protein, from Mouse, contains 619 amino acids, has 16 C2H2-type Zinc finger.

May be involved in transcriptional regulation, May play a role in DNA repair process


This is ORC ubiquitin ligase 1 protein, from Mouse, contains 722 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin ligase essential for DNA replication origin activation during S phase, Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase


This is E3 ubiquitin-protein ligase TM129 protein, from Mouse, contains 362 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2, Exploited by viral US11 proteins to mediate HLA class I proteins degradation


This is Chromosome alignment-maintaining phosphoprotein 1 protein, from Mouse, contains 802 amino acids, has 1 C2H2-type Zinc finger.

Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis, Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation, May recruit CENPE and CENPF to the kinetochore (By similarity)


This is DNA topoisomerase 1 protein, from Buchnera aphidicola subsp. Schizaphis graminum (strain Sg), contains 853 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is FCS-Like Zinc finger 8 protein, from Mouse-ear cress, contains 267 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is Probable inactive lysine-specific demethylase JMJ19 protein, from Mouse-ear cress, contains 708 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Belongs to the JARID1 histone demethylase family


This is Probable E3 ubiquitin-protein ligase ARI5 protein, from Mouse-ear cress, contains 552 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates

Belongs to the RBR family, Ariadne subfamily


This is RING-H2 finger protein ATL2 protein, from Mouse-ear cress, contains 304 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

May be involved in the early steps of the plant defense signaling pathway

Belongs to the RING-type zinc finger family, ATL subfamily


This is E3 ubiquitin-protein ligase ATL23 protein, from Mouse-ear cress, contains 163 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, UBC28 and UBC29 in vitro


This is Probable E3 ubiquitin-protein ligase LUL4 protein, from Mouse-ear cress, contains 359 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro)

Belongs to the RING-type zinc finger family, LOG2 subfamily


This is E3 ubiquitin-protein ligase RGLG5 protein, from Mouse-ear cress, contains 433 amino acids, has 1 RING-type Zinc finger.

RING-type

Together with RGLG1, mediates the ubiquitination and subsequent proteasomal degradation of the target protein PP2CA, Functions as positive regulator of abscisic acid (ABA) signaling through ABA-dependent degradation of PP2CA, a major inhibitor of ABA signaling


This is E3 ubiquitin-protein ligase PRT1 protein, from Mouse-ear cress, contains 410 amino acids, has 2 RING-type Zinc finger, has 1 ZZ-type Zinc finger.

RING-type

RING-type

ZZ-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, Functions in the N-end rule pathway of protein degradation, where it specifically recognizes and ubiquitinates proteins with a N-terminal bulky aromatic amino acid (Phe), Does not act on aliphatic hydrophobic and basic N-terminal residues (Arg or Leu) containing proteins


This is RING-H2 finger protein ATL17 protein, from Mouse-ear cress, contains 235 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Nuclear receptor subfamily 1 group I member 3 protein, from Rhesus macaque, contains 352 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes, Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Natural cytotoxicity triggering receptor 3 protein, from Rhesus macaque, contains 201 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1, Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands, It controls, for instance, NK cells cytotoxicity against tumor cells, Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation


This is Probable transcription factor elt-4 protein, from Caenorhabditis elegans, contains 72 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Probable transcription factor (PubMed:20938051, PubMed:24834345), Plays a role in regulating heme-dependent expression of heme transporter hrg-1 (PubMed:20938051), Modulates lifespan in a daf-16-dependent manner (PubMed:24834345)


This is Krueppel-like factor luna protein, from Fruit fly, contains 570 amino acids, has 3 C2H2-type Zinc finger.

Probable transcription factor that is required for cell differentiation (PubMed:14527717, PubMed:24915236), Essential for proper separation of the sister chromatids during early nuclear division cycles in the syncytial pre-blastoderm embryo (PubMed:24915236)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Aprataxin-like protein protein, from Fruit fly, contains 662 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair, Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species, Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity)


This is Fibroblast growth factor receptor 2 protein, from Planarian, contains 887 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for basic fibroblast growth factor

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Fibroblast growth factor receptor 1 protein, from Planarian, contains 854 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Zip homologous protein 4 protein, from Caenorhabditis elegans, contains 283 amino acids, has 1 RING-type Zinc finger.

RING-type

Recruited co-dependently with zhp-3 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination (PubMed:29521627, PubMed:30379819), In the early stages of pachytene, in complex with zhp-4, recruited by the zhp-1-zhp-2 heterodimer to designated crossover sites along the recombination intermediate to stabilize other pro-crossover factors such as rmh-1, msh-5 and cosa-1 (PubMed:29521627, PubMed:30379819), This in turn facilitates crossover and promotes the formation of chiasma in each meiotic nucleus at the late pachytene stage of meiosis (PubMed:29521627, PubMed:30379819), Negatively regulates double strand break formation to promote formation of the crossover intermediate (PubMed:30379819)


This is Killer cell immunoglobulin-like receptor 2DL5A protein, from Human, contains 375 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for HLA-C alleles, Inhibits the activity of NK cells thus preventing cell lysis

Belongs to the immunoglobulin superfamily


This is B-cell CLL/lymphoma 6 member B protein protein, from Human, contains 479 amino acids, has 5 C2H2-type Zinc finger.

Acts as a sequence-specific transcriptional repressor in association with BCL6, May function in a narrow stage or be related to some events in the early B-cell development


This is Zinc finger protein 567 protein, from Human, contains 647 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 664 protein, from Human, contains 261 amino acids, has 9 C2H2-type Zinc finger.


This is Follistatin-related protein 5 protein, from Human, contains 847 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like


This is Zinc finger protein 808 protein, from Human, contains 903 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 23 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Zinc finger protein 433 protein, from Human, contains 673 amino acids, has 18 C2H2-type Zinc finger, has 1 C2H2-type 13; degenerate Zinc finger.

C2H2-type 13; degenerate


This is Zinc finger protein 283 protein, from Human, contains 679 amino acids, has 15 C2H2-type Zinc finger.


This is Putative E3 ubiquitin-protein ligase UBR7 protein, from Human, contains 425 amino acids, has 1 UBR-type Zinc finger, has 1 PHD-type; atypical Zinc finger.

UBR-type

PHD-type; atypical

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway, Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation


This is Zinc finger protein 713 protein, from Human, contains 443 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 5 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Zinc finger protein 614 protein, from Human, contains 585 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 10 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; degenerate


This is Zinc finger protein 615 protein, from Human, contains 731 amino acids, has 19 C2H2-type Zinc finger.


This is Zinc finger protein 491 protein, from Human, contains 437 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 11 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate


This is Zinc finger protein 41 homolog protein, from Human, contains 198 amino acids, has 4 C2H2-type Zinc finger.

A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis


This is Zinc finger protein 441 protein, from Human, contains 693 amino acids, has 16 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 3; degenerate

C2H2-type 4; degenerate


This is Zinc finger protein 557 protein, from Human, contains 423 amino acids, has 10 C2H2-type Zinc finger.


This is Zinc finger protein ZIC 4 protein, from Human, contains 334 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical


This is Probable E3 ubiquitin-protein ligase TRIML1 protein, from Human, contains 468 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development


This is Lethal(3)malignant brain tumor-like protein 4 protein, from Human, contains 623 amino acids, has 1 CCHHC-type Zinc finger.

CCHHC-type

Putative Polycomb group (PcG) protein, PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity)


This is Zinc finger protein 579 protein, from Human, contains 562 amino acids, has 8 C2H2-type Zinc finger.


This is Zinc finger protein 784 protein, from Human, contains 323 amino acids, has 6 C2H2-type Zinc finger.


This is Zinc finger protein 485 protein, from Human, contains 441 amino acids, has 11 C2H2-type Zinc finger.


This is Zinc finger and BTB domain-containing protein 34 protein, from Human, contains 500 amino acids, has 3 C2H2-type Zinc finger.


This is Zinc finger protein 280C protein, from Human, contains 737 amino acids, has 5 C2H2-type Zinc finger.


This is Zinc finger protein 740 protein, from Human, contains 193 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 3; atypical


This is Zinc finger protein 555 protein, from Human, contains 628 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Killer cell immunoglobulin-like receptor 2DL5B protein, from Human, contains 375 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is Zinc finger protein 28 homolog protein, from Human, contains 868 amino acids, has 14 C2H2-type Zinc finger, has 1 C2H2-type 15; degenerate Zinc finger.

C2H2-type 15; degenerate

May be involved in transcriptional regulation, May have a role in embryonic development


This is Formamidopyrimidine-DNA glycosylase protein, from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025), contains 286 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is DNA topoisomerase 1 protein, from Staphylococcus aureus (strain MW2), contains 689 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is Formamidopyrimidine-DNA glycosylase protein, from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is RING-box protein 1 protein, from Atlantic salmon, contains 108 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair, CRLs complexes and arih1 collaborate in tandem to mediate ubiquitination of target proteins, arih1 mediating addition of the first ubiquitin on CRLs targets, The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components


This is Muscleblind-like protein 3 protein, from Mouse, contains 342 amino acids, has 4 C3H1-type Zinc finger.

Mediates pre-mRNA alternative splicing regulation, Acts either as activator or repressor of splicing on specific pre-mRNA targets, Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle, Antagonizes the alternative splicing activity pattern of CELF proteins (By similarity), Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction


This is Polycomb group RING finger protein 1 protein, from Mouse, contains 259 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A, Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway, Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element), Promotes cell cycle progression and enhances cell proliferation as well, May have a positive role in tumor cell growth by down-regulating CDKN1A, Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity, Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells


This is Bifunctional apoptosis regulator protein, from Mouse, contains 450 amino acids, has 1 RING-type Zinc finger.

RING-type

Apoptosis regulator, Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity)


This is E3 ubiquitin ligase Rnf121 protein, from Mouse, contains 327 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity), May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity)


This is Tripartite motif-containing protein 29 protein, from Mouse, contains 587 amino acids, has 1 B box-type Zinc finger.

B box-type

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract, Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation, In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited, Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation


This is Interferon regulatory factor 2-binding protein 1 protein, from Mouse, contains 584 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities, May act as an E3 ligase towards JDP2, enhancing its polyubiquitination, Represses ATF2-dependent transcriptional activation


This is Fc receptor-like protein 1 protein, from Mouse, contains 343 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May function as an activating coreceptor in B-cells, May function in B-cells activation and differentiation (By similarity)


This is Zinc fingers and homeoboxes protein 1 protein, from Rat, contains 873 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor, Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA, May link molecule between DNMT3B and other co-repressor proteins (By similarity)


This is OTU domain-containing protein 7A protein, from Mouse, contains 926 amino acids, has 1 A20-type Zinc finger.

Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains


This is RAS guanyl-releasing protein 4 protein, from Rat, contains 678 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP, May function in mast cells differentiation


This is Protein indeterminate-domain 6, chloroplastic protein, from Mouse-ear cress, contains 467 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical


This is Rhomboid-like protein 14, mitochondrial protein, from Mouse-ear cress, contains 334 amino acids, has 1 RanBP2-type Zinc finger.

Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis, May function in the heat-shock response pathway


This is PHD finger protein ALFIN-LIKE 6 protein, from Mouse-ear cress, contains 256 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Belladonna, contains 487 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is Squamosa promoter-binding-like protein 10 protein, from Mouse-ear cress, contains 396 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'


This is IgG receptor FcRn large subunit p51 protein, from Crab-eating macaque, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn, Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk, IgG in the milk is bound at the apical surface of the intestinal epithelium, The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids, Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation, Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation, In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Crab-eating macaque, contains 254 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG), Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC), Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity), Mediates IgG effector functions on natural killer (NK) cells, Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation, Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC, Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity), Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes, Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation, The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (By similarity), Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity), Mediates the antitumor activities of therapeutic antibodies, Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (By similarity)


This is Uncharacterized zinc finger protein CG2678 protein, from Fruit fly, contains 434 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 6 C2H2-type Zinc finger.

C2H2-type 1; atypical

May be involved in transcriptional regulation


This is Retinoic acid receptor RXR protein, from Bloodfluke planorb, contains 436 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-dependent transcription factor probably involved in the retinoic acid response pathway, Binds 9-cis-retinoic acid (9C-RA) and, to a lesser extent, docosahexaenoic acid (DHA), phytanic acid, methoprene acid and oleic acid, Binds to double-stranded DNA sequences containing direct repeats (DR) with the consensus sequence 5'-[AG]GGTCA-3' and 1, 2, 3, 4 or 5 nucleotides in between (DR1, DR2, DR3, DR4 and DR5, respectively), Binding to DR1 is strongest, Transactivates gene expression when 9C-RA or DHA is bound

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is DnaJ homolog dnj-10 protein, from Caenorhabditis elegans, contains 456 amino acids, has 1 CR-type Zinc finger.

CR-type


This is Zinc finger protein 420 protein, from Human, contains 688 amino acids, has 19 C2H2-type Zinc finger.


This is F-box only protein 30 protein, from Human, contains 745 amino acids, has 1 TRAF-type Zinc finger.

TRAF-type

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, Required for muscle atrophy following denervation


This is Zinc finger CCHC-type and RNA-binding motif-containing protein 1 protein, from Human, contains 217 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Zinc finger protein 502 protein, from Human, contains 544 amino acids, has 14 C2H2-type Zinc finger.


This is Zinc finger protein 596 protein, from Human, contains 504 amino acids, has 11 C2H2-type Zinc finger.


This is Krueppel-like factor 14 protein, from Human, contains 323 amino acids, has 3 C2H2-type Zinc finger.

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Zinc finger protein 483 protein, from Human, contains 744 amino acids, has 11 C2H2-type Zinc finger.


This is Zinc finger protein 384 protein, from Human, contains 577 amino acids, has 8 C2H2-type Zinc finger.

Transcription factor that binds the consensus DNA sequence [GC]AAAAA, Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity)


This is Glyco-Gag protein protein, from MoMLV, contains 626 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Seems to be important for efficient replication in vivo


This is Bromodomain adjacent to zinc finger domain protein 1A protein, from African clawed frog, contains 627 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Regulatory subunit of a chromatin remodeling complex, which forms ordered nucleosome arrays on chromatin and slides edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity), Involved in regulating the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (By similarity), May play a role in transcriptional regulation (PubMed:11809820)


This is Peroxisome assembly protein 12 protein, from Mouse, contains 359 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is THAP domain-containing protein 7 protein, from Mouse, contains 309 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors


This is Zinc finger and BTB domain-containing protein 7C protein, from Mouse, contains 619 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 4; degenerate


This is Tapasin-related protein protein, from Mouse, contains 451 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M, Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC), Expression seems to slow down and down-regulate MHC class I surface expression


This is General transcription factor IIH subunit 3 protein, from Mouse, contains 309 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription


This is Zinc finger CCCH-type with G patch domain-containing protein protein, from Mouse, contains 511 amino acids, has 1 C3H1-type Zinc finger.

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence, Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters, Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration, Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity)


This is Ret finger protein-like 4A protein, from Mouse, contains 287 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate


This is E3 SUMO-protein ligase TRIM60 protein, from Mouse, contains 466 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 SUMO-protein ligase that mediates SUMOylation of TAB2 leading to inhibition of NF-kappa-B and MAPK pathways by suppressing the TRAF6/TAB2/TAK1 complex


This is Nuclear receptor subfamily 2 group C member 1 protein, from Rat, contains 590 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism, Primarily repressor of a broad range of genes including ESR1 and RARB, Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, Also activator of OCT4 gene expression, Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation, Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity)


This is FCS-Like Zinc finger 5 protein, from Mouse-ear cress, contains 147 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is Protein ORANGE-LIKE, chloroplastic protein, from Mouse-ear cress, contains 315 amino acids, has 1 CR-type Zinc finger.

CR-type

May be associated with accumulation of carotenoids in chromoplasts


This is Receptor homology region, transmembrane domain- and RING domain-containing protein 2 protein, from Mouse-ear cress, contains 448 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Involved in the trafficking of vacuolar proteins, May function as a sorting receptor for protein trafficking to the protein storage vacuole (PSV) (By similarity)


This is FCS-Like Zinc finger 2 protein, from Mouse-ear cress, contains 159 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type


This is Ubiquitin carboxyl-terminal hydrolase 2 protein, from Mouse-ear cress, contains 961 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin, Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins, Is involved in resistance to the arginine analog canavanine (CAN)


This is E3 ubiquitin-protein ligase RING1 protein, from Rhesus macaque, contains 377 amino acids, has 1 RING-type Zinc finger.

RING-type

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation, H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility, Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity)


This is Zinc finger protein 480 protein, from Human, contains 535 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 10 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 1; atypical

C2H2-type 5; degenerate

Involved in transcriptional regulation as an activator


This is E3 ubiquitin-protein ligase RNF133 protein, from Human, contains 376 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Has E3 ubiquitin-protein ligase activity


This is Insulin-like growth factor-binding protein-like 1 protein, from Human, contains 278 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture, They alter the interaction of IGFs with their cell surface receptors (By similarity), May be a putative tumor suppressor protein


This is Zinc finger protein 606 protein, from Human, contains 792 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 13 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 3; degenerate


This is Zinc finger CCHC domain-containing protein 14 protein, from Human, contains 949 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type


This is Formamidopyrimidine-DNA glycosylase protein, from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e), contains 273 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Formamidopyrimidine-DNA glycosylase protein, from Yersinia pestis, contains 269 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is CD166 antigen homolog protein, from Goldfish, contains 555 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts, Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity), Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity), Mediates homotypic interactions with cells that express ALCAM, Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction, Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions, Required for normal organization of the lymph vessel network, Required for normal hematopoietic stem cell engraftment in the bone marrow, Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow, Promotes in vitro osteoblast proliferation and differentiation (By similarity), Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity), Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)


This is Thyroid hormone receptor alpha protein, from Muscovy duck, contains 401 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine


This is Inhibitor of apoptosis protein protein, from Chicken, contains 611 amino acids, has 1 RING-type Zinc finger.

RING-type


This is Semaphorin-3D protein, from Chicken, contains 761 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Induces the collapse and paralysis of neuronal growth cones, Could potentially act as repulsive cues toward specific neuronal populations, Binds to neuropilin


This is Protein CEPU-1 protein, from Chicken, contains 353 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

It may be a cellular address molecule specific to Purkinje cells, It may represent a receptor or a subunit of a receptor complex

Belongs to the immunoglobulin superfamily, IgLON family


This is Hypermethylated in cancer 1 protein protein, from Chicken, contains 676 amino acids, has 5 C2H2-type Zinc finger.

Binds specifically to the gamma F-1-binding motif of the gamma F-crystallin promoter, May have a regulatory role in sclerotome specification and/or differentiation, Isoform 2 functions as a transcriptional repressor in lens cells

Belongs to the krueppel C2H2-type zinc-finger protein family, Hic subfamily


This is Coxsackievirus and adenovirus receptor homolog protein, from Zebrafish, contains 372 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May function as a homophilic cell adhesion molecule and be essential for tight junction integrity, May also be involved in transepithelial migration of leukocytes through adhesive interactions with jaml, The interaction between both receptors may also mediate the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair (By similarity)


This is E3 ubiquitin-protein ligase arkadia-A protein, from African clawed frog, contains 923 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development by enhancing signaling of the subset of TGF-beta factors responsible for the formation of dorso-anterior tissues of Spemann's organizer (PubMed:11298453), Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP (By similarity), Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity), Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity), The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity)


This is V(D)J recombination-activating protein 2 protein, from Rainbow trout, contains 533 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical

Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination, V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments, DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends, In the RAG complex, rag2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1, It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity)


This is Estrogen receptor protein, from Zebra finch, contains 587 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Thyroid hormone receptor beta protein, from Bastard halibut, contains 395 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Fibroblast growth factor receptor 4 protein, from Iberian ribbed newt, contains 822 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis, Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19, Phosphorylates PLCG1 and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)


This is Estrogen receptor protein, from Desert grassland whiptail lizard, contains 307 amino acids, has 1 NR C4-type Zinc finger.

NR C4-type


This is Nuclear factor 7, ovary protein, from African clawed frog, contains 610 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Transcription factor that determines dorsal-ventral body axis


This is Transcription factor GATA-4 protein, from African clawed frog, contains 392 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3', Associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis, Activates the expression of cardiac MHC-alpha in vivo


This is Fibroblast growth factor receptor 4 protein, from African clawed frog, contains 828 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Hepatocyte nuclear factor 4-alpha protein, from African clawed frog, contains 464 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator; binds and activates the promoter for the HNF1-alpha gene (PubMed:8808405), Potential initiator of a transcriptional cascade within a subset of cells committed to a specific developmental program (PubMed:8808405), Could be a determinant for asymmetry in early development (PubMed:8808405), May play a role in the regulation of the circadian clock (By similarity)


This is V(D)J recombination-activating protein 2 protein, from African clawed frog, contains 520 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical


This is Zinc finger protein SNAI2 protein, from African clawed frog, contains 266 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; atypical Zinc finger.

C2H2-type 5; atypical

Probable transcriptional repressor, Acts downstream of snai1 in the specification of the neural crest and neural crest migration

Belongs to the snail C2H2-type zinc-finger protein family


This is Cytoplasmic 60S subunit biogenesis factor ZNF622 protein, from Mouse, contains 476 amino acids, has 2 U1-type Zinc finger.

Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit


This is Pleckstrin homology domain-containing family F member 2 protein, from Mouse, contains 249 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity), Enhances cellular sensitivity to TNF-induced apoptosis


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like protein, from Mouse, contains 637 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs), Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs, Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation

Belongs to the Dus family, Dus3 subfamily


This is Ligand of Numb protein X 2 protein, from Mouse, contains 687 amino acids, has 1 RING-type Zinc finger.

RING-type


This is RNA-binding protein 5 protein, from Mouse, contains 815 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type Zinc finger.

Component of the spliceosome A complex, Regulates alternative splicing of a number of mRNAs, May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron, May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2, In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis, In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity)


This is Nuclear factor 7, brain protein, from African clawed frog, contains 609 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Fc receptor-like A protein, from Mouse, contains 352 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be implicated in B-cell differentiation and lymphomagenesis


This is GATA zinc finger domain-containing protein 1 protein, from Mouse, contains 266 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3)


This is Transcription factor IIIA protein, from Human, contains 365 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Involved in ribosomal large subunit biogenesis, Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes, It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868), Also binds the transcribed 5S RNA's (By similarity)


This is DNA topoisomerase 1 protein, from Rickettsia conorii (strain ATCC VR-613 / Malish 7), contains 776 amino acids, has 1 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is Specificity protein transcription factor 1 protein, from Caenorhabditis elegans, contains 298 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor which modulates gene expression, thereby acting as an ASJ sensory neuron terminal selector gene


This is E3 ubiquitin-protein ligase DA2L protein, from Mouse-ear cress, contains 335 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase involved in the regulation of organ and seed size, Probably functions to restrict cell proliferation during organ and seed development


This is Zinc finger CCCH domain-containing protein 37 protein, from Mouse-ear cress, contains 524 amino acids, has 6 C3H1-type Zinc finger.

Involved in flower development (PubMed:11595801, PubMed:12530963), Functions in floral reproductive organ identity by binding AGAMOUS (AG) pre-mRNA and promoting its processing, Functions in association with HUA2 and HEN4 (PubMed:12530963)


This is SAGA-associated factor 11 protein, from Mouse-ear cress, contains 181 amino acids, has 1 SGF11-type Zinc finger.

Component of a deubiquitination module (DUB module) that specifically deubiquinates monoubiquinated histone H2B (H2Bub) (PubMed:29588169, PubMed:30192741), Does not seem to be a component of the TREX-2 complex (PubMed:29588169), Seems to act independently of the SAGA multiprotein complex (PubMed:30192741), The DUB module is responsible for the major H2Bub deubiquitinase activity in Arabidopsis (PubMed:30192741)


This is Estrogen receptor beta protein, from White-tufted-ear marmoset, contains 530 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner


This is Platelet endothelial cell adhesion molecule protein, from Pig, contains 740 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions, Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes, Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions, Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils, Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal, Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes, Modulates bradykinin receptor BDKRB2 activation, Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells, Induces susceptibility to atherosclerosis


This is Patr class I histocompatibility antigen, alpha chain G protein, from Chimpanzee, contains 338 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is Patr class I histocompatibility antigen, alpha chain E protein, from Chimpanzee, contains 350 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules


This is Optineurin protein, from Crab-eating macaque, contains 571 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8, Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation, Negatively regulates the induction of IFNB in response to RNA virus infection, Plays a neuroprotective role in the eye and optic nerve, Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52


This is E3 ubiquitin-protein ligase RNF125 protein, from Crab-eating macaque, contains 232 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53, Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation, Mediates ubiquitination and subsequent degradation of p53/TP53, Mediates ubiquitination and subsequent degradation of JAK1, Acts as a positive regulator of T-cell activation


This is Steroidogenic factor 1 protein, from Tammar wallaby, contains 463 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator, Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues, Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B, Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes, 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1, The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity, Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3, Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is Sialic acid-binding Ig-like lectin 12 protein, from Chimpanzee, contains 597 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family