This is E3 ubiquitin-protein ligase TRIM39 protein, from Mouse, contains 488 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase (By similarity), May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity), Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity), Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity)


This is Tripartite motif-containing protein 2 protein, from Mouse, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11, Plays a neuroprotective function, May play a role in neuronal rapid ischemic tolerance, Plays a role in antiviral immunity and limits new world arenavirus infection independently of its ubiquitin ligase activity by decreasing virus internalization (PubMed:30726215)


This is Fez family zinc finger protein 2 protein, from Mouse, contains 455 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor, Required for the specification of corticospinal motor neurons and other subcerebral projection neurons, May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation, Controls the development of dendritic arborization and spines of large layer V pyramidal neurons, Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Transcription factor Sp6 protein, from Mouse, contains 376 amino acids, has 3 C2H2-type Zinc finger.

Promotes cell proliferation (PubMed:14551215), Plays a role in tooth germ growth (PubMed:30426815), Plays a role in the control of enamel mineralization, Binds the AMBN promoter (By similarity)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase RNF114 protein, from Mouse, contains 229 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates, In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity, Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3, May promote the ubiquitination of TRAF6 as well, Acts also as a negative regulator of T-cell activation, Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation, Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C, This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence, May play a role in spermatogenesis


This is SLAM family member 6 protein, from Mouse, contains 351 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922), Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (By similarity), Positive signaling in NK cells implicates phosphorylation of VAV1, NK cell activation seems to depend on SH2D1B and not on SH2D1A (By similarity), In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695), Promotes T cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (By similarity), Promotes recruitment of RORC to the IL-17 promoter (By similarity), In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response (PubMed:25926831), In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells, Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP (PubMed:22683125), However, reported to mediated T-cell adhesion, to participate in stable T-cell:B-cell interactions and to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (PubMed:20153220, PubMed:25801429), Involved in regulation of autoimmunity, Isoform 3 may be suppressor of pathogenic T-cell proliferation (PubMed:21422172)


This is Krueppel-like factor 2 protein, from Rat, contains 351 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription, Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (By similarity)


This is Zinc finger protein HD1 protein, from Rice, contains 395 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Probable transcription factor involved in the regulation of flower development, Required for the promotion of flowering under short day (SD) conditions and the suppression of flowering under long day (LD) conditions, Regulates positively the floral activator HEADING DATE 3a (HD3A) under SD and negatively under LD conditions


This is Chromatin remodeling protein SHL protein, from Mouse-ear cress, contains 228 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Chromatin remodeling factor that binds to methylated histone (e,g, H3K4me2/3) to prevent their acetylation (e,g, H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulate the transcription of target genes (PubMed:25281686), Required during development and for fertility, probably by modulating developmental gene expression (PubMed:11129039, PubMed:15082927, PubMed:25281686), Promotes development speed, but at fitness cost (PubMed:11129039), Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering, Negatively regulates the expression of the floral integrator SOC1, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation (PubMed:25281686)


This is E3 ubiquitin-protein ligase RZFP34 protein, from Mouse-ear cress, contains 291 amino acids, has 1 CHY-type Zinc finger, has 1 CTCHY-type Zinc finger, has 1 RING-type; atypical Zinc finger.

CHY-type

CTCHY-type

RING-type; atypical

Possesses E3 ubiquitin-protein ligase activity in vitro, Mediates mainly 'Lys-48'-linked polyubiquitination, Promotes abscisic acid (ABA)-induced stomatal closure, reactive oxygen species (ROS) production and drought tolerance (PubMed:26508764), Involved in the regulation of stomatal aperture (PubMed:25002225)


This is Zinc finger protein NUTCRACKER protein, from Mouse-ear cress, contains 466 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription activator that binds to the DNA sequence 5'-CTTTTGTCC-3' (PubMed:21265895, PubMed:25929516), Regulates photoperiodic flowering by modulating sugar transport and metabolism (PubMed:21265895, PubMed:25929516), Regulates SUS1 and SUS4 (PubMed:21265895), Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:25829440), Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:25829440)


This is NF-X1-type zinc finger protein NFXL2 protein, from Mouse-ear cress, contains 883 amino acids, has 1 RING-type; degenerate Zinc finger, has 11 NF-X1-type Zinc finger.

RING-type; degenerate

Probable transcriptional regulator, May mediate E2- or E3-dependent ubiquitination, Required to gate light sensitivity during the night, Regulates the speed of the clock by acting in the feedback loop between CCA1, LHY and APRR1/TOC1, Promotes the expression of CCA1 at night but not by days, This activational effect is enhanced by interaction with ADO1/ZTL, Association with ADO1/ZTL is not leading to the degradation of NFXL2, Confers sensitivity to osmotic stress such as high salinity, Prevents H(2)O(2) production and abscisic acid accumulation, Part of a regulatory network that integrates the biosynthesis and action of abscisic acid, reactive oxygen species and cuticle components


This is Diacylglycerol kinase 2 protein, from Mouse-ear cress, contains 712 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule (PubMed:14665624), PA is required for plant development and responses to abiotic stress and pathogen attack (Probable), May be involved in the accumulation of PA during cold stress (Probable), Involved in response to freezing stress by modulating the accumulation of PA (PubMed:29853600), Exhibits high specificity for the unsaturated DAG analogs 1-stearoyl-2-arachidonoyl-sn-glycerol (1,2-SAG) and 1,2-dioleoyl-sn-glycerol (1,2-DOG) (PubMed:14665624, PubMed:16081412), Exhibits high specificity for 1-palmitoyl, 2-oleoyl-sn-glycerol (1,2 POG), 1-stearoyl, 2-linoleoyl-sn-glycerol (1,2-SLG) and 1-oleoyl, 2-palmitoyl-sn-glycerol (1,2-OPG) (PubMed:16081412), Has almost no activity toward 1,2-dioctanoyl-sn-glycerol (1,2-DOCG), 1,2-dipalmitoyl-sn-glycerol (1,2-DPG), 1,2-dimyristoyl-sn-glycerol (1,2-DMG) and 1-oleoyl-2-acetyl-sn-glycerol (1,2-OAG) (PubMed:16081412), Functions together with DGK4 in male gametophyte development and biosynthesis of phosphatidylglycerol and phosphatidylinositol in the endoplasmic reticulum (ER) (PubMed:32471859), Involved in PA production for pollen grain growth, as well as leaf and root growth (PubMed:32471859)

Belongs to the eukaryotic diacylglycerol kinase family


This is Probable E3 ubiquitin-protein ligase ARI14 protein, from Mouse-ear cress, contains 506 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger, has 1 RanBP2-type Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (PubMed:12446796), Regulates negatively male gametophyte formation and double fertilization (PubMed:20478994)

Belongs to the RBR family, Ariadne subfamily


This is Splicing factor SF3a60 homolog protein, from Mouse-ear cress, contains 504 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Splicing factor homolog to SF3a60 that may be involved in pre-spliceosome formation, Is necessary for gametic cell fate determination


This is FCS-Like Zinc finger 1 protein, from Mouse-ear cress, contains 177 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is BOI-related E3 ubiquitin-protein ligase 1 protein, from Mouse-ear cress, contains 294 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase involved in regulation of abiotic stress responses, Not involved in ubiquitination of MYB108/BOS1, Has no effect on the stability of the DELLA proteins


This is SWR1 complex subunit 6 protein, from Mouse-ear cress, contains 171 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A,F/Z leading to transcriptional regulation of selected genes (e,g, FLC) by chromatin remodeling, Coodinates SWR1-C, FRI-C (FLC transcription activator complex), histone methyltransferase and general transcription factors, Represses flowering by positively regulating FLC and MAF4, Binds to the promoter region of FLC chromatin


This is Protein VERNALIZATION INSENSITIVE 3 protein, from Mouse-ear cress, contains 620 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Plays a central role in vernalization by mediating the initial transcriptional repression of the homeotic gene FLC, a floral repressor, after a cold treatment, However, due to its transient expression, it cannot maintain repression of FLC, which is then maintained by Polycomb Group complexes containing VRN2 throughout development, Required to deacetylate histones on the FLC promoter, Together with VIL1, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e,g, chromatin modifications, histone deacetylation, and trimethylated H3 'Lys-4' H3K4me3 and 'Lys-27' H3K27me3) and with acquisition of competence to flower


This is ADP-ribosylation factor GTPase-activating protein AGD1 protein, from Mouse-ear cress, contains 828 amino acids, has 1 C4-type Zinc finger.

Probable GTPase-activating protein (By similarity), Regulator of membrane trafficking, Required for maintaining a straight growth of root hairs


This is Zinc-finger homeodomain protein 10 protein, from Mouse-ear cress, contains 334 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate

Putative transcription factor, Probably involved in establishing polarity during leaf development through the gibberellic acid (GA) signaling pathway


This is BTB/POZ and TAZ domain-containing protein 4 protein, from Mouse-ear cress, contains 372 amino acids, has 1 TAZ-type Zinc finger.

TAZ-type

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins


This is E3 ubiquitin-protein ligase ORTHRUS 1 protein, from Mouse-ear cress, contains 617 amino acids, has 1 PHD-type Zinc finger, has 2 RING-type Zinc finger.

PHD-type

RING-type

RING-type

E3 ubiquitin-protein ligase, Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing, Mediates ubiquitination with the E2 ubiquitin-conjugating enzymes UBC11, UBC8 and UBC8 homologs (e,g, UBC10, UBC11, UBC28 and UBC29) but not with UBC27, UBC30, UBC32, UBC34 and UBC36, Promotes methylation-mediated gene silencing leading, for example, to early flowering, Can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate


This is Zinc-finger homeodomain protein 1 protein, from Mouse-ear cress, contains 279 amino acids, has 1 ZF-HD dimerization-type Zinc finger.

ZF-HD dimerization-type


This is Putative E3 ubiquitin-protein ligase RING1a protein, from Mouse-ear cress, contains 522 amino acids, has 1 RING-type Zinc finger.

RING-type

As part of the PRC1-like complex, repress class I KNOX gene expression, PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility


This is ADP-ribosylation factor GTPase-activating protein AGD5 protein, from Mouse-ear cress, contains 483 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF) (PubMed:19429787), Mediates clathrin-dependent trafficking of vacuolar cargo from the trans-Golgi network (TGN) (PubMed:23771894), Promotes plant growth (PubMed:23771894, PubMed:25763490), Involved in the regulation of membrane trafficking and cell separation during floral organ shedding and abscission (PubMed:19429787, PubMed:20081191, PubMed:20230490, PubMed:23963677), Prevents abscission zone (AZ) cells enlargement (PubMed:23963677, PubMed:25763490), Exhibits ARF-GTPase activity toward ARF1 at TGN (PubMed:21105926)


This is Histone acetyltransferase of the MYST family 1 protein, from Mouse-ear cress, contains 445 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Histone acetyltransferase which may be involved in transcriptional activation, Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925), Essential for gametophyte development (PubMed:19040736), Involved in DNA repair after UV-B exposure (PubMed:22170978), Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925)


This is RNA-binding NOB1-like protein protein, from Mouse-ear cress, contains 602 amino acids, has 1 NOB1 Zinc finger.

Essential protein required during embryogenesis and pollen development (PubMed:23382868), Endonuclease cleaving pre-rRNA at the 3' end of the mature 18S rRNA (D-site); cleaves 20S pre-rRNA in the cytoplasm (PubMed:23382868), Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (PubMed:23382868)


This is Dof zinc finger protein DOF5.6 protein, from Mouse-ear cress, contains 372 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity), Promotes expression (PubMed:19915089), The PEAR proteins (e,g, DOF2,4, DOF5,1, DOF3,2, DOF1,1, DOF5,6 and DOF5,3) activate gene expression that promotes radial growth of protophloem sieve elements (PubMed:30626969), Involved in the regulation of interfascicular cambium formation and vascular tissue development, particularly at a very early stage during inflorescence stem development; promotes both cambium activity and phloem specification, but prevents xylem specification (PubMed:19915089)


This is BTB/POZ and TAZ domain-containing protein 1 protein, from Mouse-ear cress, contains 365 amino acids, has 1 TAZ-type Zinc finger.

TAZ-type

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Also targeted for degradation by the 26S proteasome pathway, May be involved in gametophyte development


This is PHD finger protein MALE STERILITY 1 protein, from Mouse-ear cress, contains 672 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Transcriptional activator required for anther and post-meiotic pollen development and maturation, Seems to regulate inflorescence branching and floral development, May control tapetal development by directly regulating tapetal programmed cell death (PCD) and breakdown, Implicated in pollen cytosolic components and wall development (e,g, exine and intine formation)


This is Splicing factor U2af small subunit B protein, from Mouse-ear cress, contains 283 amino acids, has 2 C3H1-type Zinc finger.

Necessary for the splicing of pre-mRNA (By similarity), Probably active at the 3' splice sites

Belongs to the splicing factor SR family


This is Histone-lysine N-methyltransferase ATXR6 protein, from Mouse-ear cress, contains 349 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone methyltransferase that specifically monomethylates 'Lys-27' of histone H3 (H3K27me1), Has higher activity on nucleosomes containing H3,1 than H3,3, Involved in the formation of constitutive heterochromatin and the silencing of heterochromatic elements, May act as a positive regulator of the G1-S transition, Influences which sets of rRNA gene variants are expressed or silenced, Up-regulated by E2FB

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily


This is Ubiquitin carboxyl-terminal hydrolase 15 protein, from Mouse-ear cress, contains 924 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin, Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (Probable), Involved in the regulation of organ size, Acts as positive regulator of cell proliferation, Possesses deubiquitinating enzyme activity in vitro, The enzyme activity of UBP15 is required for its function in regulation of cell proliferation (PubMed:18485060), Functions antagonistically in a common pathway with DA1 to regulate seed size, Acts maternally to regulate seed size by promoting cell proliferation in the integuments of ovules and developing seeds, Functions independently of DA2 and BB (PubMed:24585836)


This is 5'-3' exoribonuclease 4 protein, from Mouse-ear cress, contains 947 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Possesses 5'->3' exoribonuclease activity, Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor, Degrades miRNA target cleavage products that lack a 5'-cap structure, Antagonizes the negative feedback regulation on EIN3 by promoting EBF1 and EBF2 mRNA decay, which consequently allows the accumulation of EIN3 protein to trigger the ethylene response

Belongs to the 5'-3' exonuclease family, XRN2/RAT1 subfamily


This is Protein indeterminate-domain 16 protein, from Mouse-ear cress, contains 362 amino acids, has 2 C2H2-type Zinc finger, has 1 CCHC-type 1; atypical Zinc finger, has 1 CCHC-type 2; atypical Zinc finger.

CCHC-type 1; atypical

CCHC-type 2; atypical

Transcription factor regulating lateral organ morphogenesis and gravitropic responses (PubMed:24039602), Has a redundant role with IDD14 in directing leaf and floral organ morphogenesis (PubMed:24039602), Acts cooperatively with IDD15 to control silique and branche orientation (PubMed:24039602), Involved in the establishment of auxin gradients through the regulation of auxin biosynthesis and transport (PubMed:24039602)


This is Zinc-finger homeodomain protein 5 protein, from Mouse-ear cress, contains 309 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate

Putative transcription factor, Binds DNA at 5'-ATTA-3' consensus promoter regions, Regulates floral architecture and leaf development, Regulators in the abscisic acid (ABA) signal pathway that confers sensitivity to ABA in an ARF2-dependent manner


This is Histone deacetylase HDT1 protein, from Mouse-ear cress, contains 245 amino acids, has 1 C2H2-type Zinc finger.

Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Required for histone H3 'Lys-9' deacetylation, Involved in rRNA gene silencing in nucleolar dominance, Seems to be implicated in the regulation of genes involved in seeds development

Belongs to the histone deacetylase HD2 family


This is ADP-ribosylation factor GTPase-activating protein AGD12 protein, from Mouse-ear cress, contains 337 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF), Binds phosphatidylinositol 3-monophosohate (PI-3-P) and anionic phospholipids


This is Zinc finger protein WIP6 protein, from Mouse-ear cress, contains 302 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

C2H2-type 4; atypical

Probable transcriptional regulator (Probable), Involved in leaf vasculature patterning (PubMed:18643975)

Belongs to the WIP C2H2-type zinc-finger protein family


This is Serine/arginine-rich splicing factor RS2Z32 protein, from Mouse-ear cress, contains 284 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Probably involved in intron recognition and spliceosome assembly

Belongs to the splicing factor SR family, RS2Z subfamily


This is Androgen receptor protein, from Pig, contains 896 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation, Transcription activation is also down-regulated by NR0B2, Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Nectin-1 protein, from Pig, contains 515 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Probably involved in cell adhesion, Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells


This is Progesterone receptor protein, from Dog, contains 939 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator of several progesteron-dependent promoters in a variety of cell types, Involved in activation of SRC-dependent MAPK signaling on hormone stimulation


This is Lysine-specific demethylase 7 homolog protein, from Caenorhabditis elegans, contains 910 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone demethylase required for nervous system development (PubMed:20346720), Specifically demethylates dimethylated 'Lys-9', 'Lys-23' and 'Lys-27' (H3K9me2, H3K23me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code (PubMed:20346720, PubMed:21251613, PubMed:20567262, PubMed:26476455), Promotes mitochondrial stress-induced longevity (PubMed:27133168)

Belongs to the JHDM1 histone demethylase family, JHDM1D subfamily


This is NF-kappa-B essential modulator protein, from Fruit fly, contains 387 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for NF-kappa-B (Rel) activation, Required for antibacterial immune response


This is Egl nine homolog 1 protein, from Human, contains 426 amino acids, has 1 MYND-type; atypical Zinc finger.

MYND-type; atypical

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A, Also hydroxylates HIF2A, Has a preference for the CODD site for both HIF1A and HIF1B, Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex, Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes, EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality, Target proteins are preferentially recognized via a LXXLAP motif


This is Hyaluronan and proteoglycan link protein 2 protein, from Human, contains 340 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Mediates a firm binding of versican V2 to hyaluronic acid, May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization, Binds to hyaluronic acid (By similarity)

Secreted, extracellular space, extracellular matrix


This is PR domain zinc finger protein 14 protein, from Human, contains 571 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 5 C2H2-type Zinc finger.

C2H2-type 1; atypical

Transcription factor that has both positive and negative roles on transcription, Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells, May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression, Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity), Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer, Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Zinc finger protein 350 protein, from Human, contains 532 amino acids, has 8 C2H2-type Zinc finger.

Transcriptional repressor, Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3


This is E3 ubiquitin-protein ligase makorin-2 protein, from Human, contains 416 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity), Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity), Plays a role in the regulation of spermiation and in male fertility (By similarity)


This is DNA-dependent metalloprotease SPRTN protein, from Human, contains 489 amino acids, has 1 UBZ4-type Zinc finger.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:27852435, PubMed:27871366, PubMed:27871365, PubMed:32649882, PubMed:30893605), DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:27852435, PubMed:27871366, PubMed:27871365, PubMed:32649882), Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (PubMed:27852435, PubMed:27871366, PubMed:27871365, PubMed:32649882), Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (PubMed:27871366), Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs (By similarity), SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity), Involved in recruitment of VCP/p97 to sites of DNA damage (PubMed:22902628, PubMed:23042605, PubMed:23042607, PubMed:32152270), Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation (PubMed:31316063), Does not activate CHEK1 in response to DNA damage (PubMed:31316063), May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA (PubMed:22681887, PubMed:22894931, PubMed:22902628, PubMed:22987070), Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (PubMed:22681887)


This is RING finger protein 32 protein, from Human, contains 362 amino acids, has 1 RING-type 1; atypical Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type 1; atypical

RING-type 2; atypical


This is Zinc finger MYND domain-containing protein 12 protein, from Human, contains 365 amino acids, has 1 MYND-type; atypical Zinc finger.

MYND-type; atypical


This is 5'-3' exoribonuclease 2 protein, from Human, contains 950 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Possesses 5'->3' exoribonuclease activity (By similarity), May promote the termination of transcription by RNA polymerase II, During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase, The processive degradation of this 3' fragment by this protein may promote termination of transcription, Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224)


This is Ubiquitin carboxyl-terminal hydrolase 44 protein, from Human, contains 712 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset, Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17443180), Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C (PubMed:17443180), Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint (PubMed:17443180), Promotes also the deubiquitination of histone H2A and H2B (PubMed:23615962, PubMed:27880911), Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (PubMed:23615962), Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (By similarity), Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability (PubMed:32644293), Plays also a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (PubMed:31968013)

Belongs to the peptidase C19 family, USP44 subfamily


This is E3 ubiquitin-protein ligase RNF38 protein, from Human, contains 515 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies, Exhibits preference for UBE2D2 as a E2 enzyme


This is Sharpin protein, from Human, contains 387 amino acids, has 1 RanBP2-type Zinc finger.

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181), LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181), Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181), LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181), The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331), LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331), The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331), Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998)


This is Rac GTPase-activating protein 1 protein, from Human, contains 632 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis, Required for proper attachment of the midbody to the cell membrane during cytokinesis, Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956), Has a critical role in erythropoiesis (PubMed:34818416), Also involved in the regulation of growth-related processes in adipocytes and myoblasts, May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation, Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA, Essential for the early stages of embryogenesis, May play a role in regulating cortical activity through RHOA during cytokinesis, May participate in the regulation of sulfate transport in male germ cells


This is Protein mono-ADP-ribosyltransferase PARP12 protein, from Human, contains 701 amino acids, has 5 C3H1-type Zinc finger.

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins


This is Zinc finger CW-type PWWP domain protein 1 protein, from Human, contains 648 amino acids, has 1 CW-type Zinc finger.

CW-type

Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) (PubMed:32744506, PubMed:20826339), Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity), Essential for male fertility and spermatogenesis (By similarity), Required for meiosis prophase I progression in male but not in female germ cells (By similarity)


This is RING finger protein 208 protein, from Human, contains 261 amino acids, has 1 RING-type Zinc finger.

RING-type


This is GDNF-inducible zinc finger protein 1 protein, from Human, contains 711 amino acids, has 10 C2H2-type Zinc finger.

Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'), May be regulating VSX2/HOX10 expression


This is Inhibitor of growth protein 2 protein, from Human, contains 280 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53, Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones, ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs)


This is B-cell lymphoma/leukemia 11A protein, from Human, contains 835 amino acids, has 6 C2H2-type Zinc finger.

Transcription factor (PubMed:16704730, PubMed:29606353), Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491), Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353), Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765), Involved in brain development (PubMed:27453576), May play a role in hematopoiesis (By similarity), Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity), May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity)


This is Probable E3 ubiquitin-protein ligase IRF2BPL protein, from Human, contains 796 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064), Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064), Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable), Also acts as a transcriptional regulator of genes controlling female reproductive function, May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)


This is Rabenosyn-5 protein, from Human, contains 784 amino acids, has 1 C2H2-type Zinc finger, has 1 FYVE-type Zinc finger.

FYVE-type

Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes, Required for endosome fusion either homotypically or with clathrin coated vesicles, Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes, Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane, Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713), Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388)


This is Vacuolar protein sorting-associated protein 11 homolog protein, from Human, contains 941 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways, Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion, The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes, The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203), Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203), Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287), Involved in the retrograde Shiga toxin transport (PubMed:23593995)


This is CXXC-type zinc finger protein 4 protein, from Human, contains 198 amino acids, has 1 CXXC-type Zinc finger.

CXXC-type

Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity), Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034)


This is RING finger protein 39 protein, from Human, contains 420 amino acids, has 1 RING-type Zinc finger.

RING-type

May play a role in prolonged long term-potentiation (LTP) maintenance


This is Zinc finger protein Eos protein, from Human, contains 585 amino acids, has 6 C2H2-type Zinc finger.

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence, Transcriptional repressor, Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2, May be involved in the development of central and peripheral nervous systems, Essential for the inhibitory function of regulatory T-cells (Treg), Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Forkhead box protein P1 protein, from Human, contains 677 amino acids, has 1 C2H2-type Zinc finger.

Involved in transcriptional regulation in embryonic stem cells (ESCs), Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes, Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763), Promotes ESC self-renewal and pluripotency (By similarity)


This is tRNA dimethylallyltransferase protein, from Human, contains 467 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:11111046, PubMed:24126054, PubMed:24901367, PubMed:34774131), Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (PubMed:24126054), TRIT1 is therefore required for selenoprotein expression (PubMed:24126054)


This is Semaphorin-4A protein, from Human, contains 761 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity), Regulates glutamatergic and GABAergic synapse development (By similarity), Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity), Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity), Promotes phosphorylation of TIMD2 (By similarity), Inhibits angiogenesis (By similarity), Promotes axon growth cone collapse (By similarity), Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity)


This is Zinc fingers and homeoboxes protein 3 protein, from Human, contains 956 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor, Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation, Is a regulator of podocyte gene expression during primary glomerula disease, Binds to promoter DNA


This is E3 ubiquitin-protein ligase NRDP1 protein, from Human, contains 317 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 SIAH-type; degenerate Zinc finger.

RING-type; degenerate

SIAH-type; degenerate

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins, Polyubiquitinates MYD88, Negatively regulates MYD88-dependent production of pro-inflammatory cytokines, Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity), Promotes also activation of TBK1 and IRF3, Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors, Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity), Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation, Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis, Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state, The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy, Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970)


This is PR domain zinc finger protein 13 protein, from Human, contains 707 amino acids, has 4 C2H2-type Zinc finger.

May be involved in transcriptional regulation, Is required for the differentiation of KISS1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus, Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development (By similarity)


This is PR domain zinc finger protein 12 protein, from Human, contains 367 amino acids, has 3 C2H2-type Zinc finger.

Involved in the positive regulation of histone H3-K9 dimethylation


This is Zinc finger and SCAN domain-containing protein 16 protein, from Human, contains 348 amino acids, has 4 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Transcription factor COE3 protein, from Human, contains 596 amino acids, has 1 C5-type Zinc finger.

Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370), Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)


This is Zinc finger protein 768 protein, from Human, contains 540 amino acids, has 10 C2H2-type Zinc finger.

Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274), Required for cell homeostasis (PubMed:34404770), May be involved in transcriptional regulation (Probable)


This is rRNA N6-adenosine-methyltransferase ZCCHC4 protein, from Human, contains 513 amino acids, has 1 GRF-type Zinc finger, has 1 CCHC-type Zinc finger.

GRF-type

CCHC-type

rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31799605, PubMed:31695039), N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910, PubMed:31799605)


This is Zinc finger protein Pegasus protein, from Human, contains 419 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188), Involved in megakaryocyte differentiation


This is CXADR-like membrane protein protein, from Human, contains 373 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be involved in the cell-cell adhesion, May play a role in adipocyte differentiation and development of obesity, Is required for normal small intestine development


This is Speckle targeted PIP5K1A-regulated poly(A) polymerase protein, from Human, contains 874 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410), Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197), In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410), In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955), However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197), Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955), Not involved in replication-dependent histone mRNA degradation

Belongs to the DNA polymerase type-B-like family


This is E3 ubiquitin-protein ligase RNF167 protein, from Human, contains 350 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:35114100, PubMed:33594058), Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058), Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100), Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562), Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289), Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617), Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890), Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481), Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844), Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289)


This is Zinc finger protein 552 protein, from Human, contains 407 amino acids, has 6 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 3; degenerate

C2H2-type 4; degenerate


This is Histone-lysine N-methyltransferase SMYD3 protein, from Human, contains 428 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Histone methyltransferase, Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068), Also methylates 'Lys-5' of histone H4 (PubMed:22419068), Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609), Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family


This is V-type immunoglobulin domain-containing suppressor of T-cell activation protein, from Human, contains 311 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993), May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity), May stimulate MMP14-mediated MMP2 activation (PubMed:20666777)


This is Zinc finger protein 703 protein, from Human, contains 590 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters, Regulates cell adhesion, migration and proliferation, May be required for segmental gene expression during hindbrain development


This is Zinc finger protein 696 protein, from Human, contains 374 amino acids, has 9 C2H2-type Zinc finger.

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Histone acetyltransferase KAT8 protein, from Human, contains 458 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126), May influence the function of ATM (PubMed:15923642), As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126), As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026), That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026), Can also acetylate TP53/p53 at 'Lys-120'


This is E3 ubiquitin-protein transferase RMND5A protein, from Human, contains 391 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972), Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972), The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972)


This is Zinc finger protein 395 protein, from Human, contains 513 amino acids, has 1 C2H2-type Zinc finger.

Plays a role in papillomavirus genes transcription


This is Pleckstrin homology domain-containing family F member 2 protein, from Human, contains 249 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport, Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467)


This is E3 ubiquitin-protein ligase TRIM45 protein, from Human, contains 580 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779), Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779), May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway


This is tRNA endonuclease ANKZF1 protein, from Human, contains 726 amino acids, has 1 C2H2-type Zinc finger.

Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:30244831, PubMed:29632312, PubMed:31011209), The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:30244831, PubMed:29632312, PubMed:31011209), ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209), ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755), Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725)


This is E3 ubiquitin-protein ligase MARCHF7 protein, from Human, contains 704 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077), May be involved in T-cell proliferation by regulating LIF secretion (By similarity), May play a role in lysosome homeostasis (PubMed:31270356)


This is Zinc finger protein 408 protein, from Human, contains 720 amino acids, has 10 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Putative E3 ubiquitin-protein ligase UNKL protein, from Human, contains 680 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

May participate in a protein complex showing an E3 ligase activity regulated by RAC1, Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b, Intrinsic E3 ligase activity has not been proven


This is RING finger protein 122 protein, from Human, contains 155 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

May induce necrosis and apoptosis, May play a role in cell viability


This is Protein lin-28 homolog A protein, from Human, contains 209 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876), Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable), 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis, Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization, Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA, Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression, Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c, Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferases (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984), This results in the terminal uridylation of target pre-miRNAs (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984), Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation, The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984), Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins, Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation, Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity)


This is Zinc finger matrin-type protein 3 protein, from Human, contains 289 amino acids, has 3 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

Acts as a bona fide target gene of p53/TP53, May play a role in the TP53-dependent growth regulatory pathway, May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus


This is Histone deacetylase complex subunit SAP30L protein, from Human, contains 183 amino acids, has 1 Atypical Zinc finger.

Atypical

Functions as transcription repressor; its activity is marginally lower than that of isoform 1


This is Transcription factor COE2 protein, from Human, contains 575 amino acids, has 1 C5-type Zinc finger.

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation, Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)


This is Transcription factor IIIB 50 kDa subunit protein, from Human, contains 419 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase III transcription, Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071), Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071), Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071), Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071)


This is Interleukin-1 receptor-like 2 protein, from Human, contains 575 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for interleukin-36 (IL36A, IL36B and IL36G), After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity), The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system, Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway

Belongs to the interleukin-1 receptor family


This is Sp110 nuclear body protein protein, from Human, contains 689 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Transcription factor, May be a nuclear hormone receptor coactivator, Enhances transcription of genes with retinoic acid response elements (RARE)


This is POZ-, AT hook-, and zinc finger-containing protein 1 protein, from Human, contains 687 amino acids, has 7 C2H2-type Zinc finger.

(Microbial infection) Plays a positive role in viral cDNA synthesis


This is Zinc finger FYVE domain-containing protein 1 protein, from Human, contains 777 amino acids, has 2 FYVE-type Zinc finger.

FYVE-type

FYVE-type

(Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication


This is T-lymphocyte surface antigen Ly-9 protein, from Human, contains 655 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction, Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727), Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874), May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response, May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells, May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity)


This is Zinc finger protein 286A protein, from Human, contains 521 amino acids, has 10 C2H2-type Zinc finger.


This is Leucine-rich repeat-containing protein 4 protein, from Human, contains 653 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Synaptic adhesion protein, Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins, Organize the lamina/pathway-specific differentiation of dendrites, Plays an important role for auditory synaptic responses, Involved in the suppression of glioma (By similarity)


This is Zinc finger and BTB domain-containing protein 20 protein, from Human, contains 741 amino acids, has 5 C2H2-type Zinc finger.

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661), Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)


This is Lateral signaling target protein 2 homolog protein, from Human, contains 887 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Negative regulator of epidermal growth factor receptor (EGFR) signaling, Acts by promoting EGFR degradation in endosomes when not monoubiquitinated


This is E3 ubiquitin-protein ligase MSL2 protein, from Human, contains 577 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure, Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A, This activity is greatly enhanced by heterodimerization with MSL1, H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1


This is Leucine-rich repeat-containing protein 4C protein, from Human, contains 640 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May promote neurite outgrowth of developing thalamic neurons


This is Zinc finger and BTB domain-containing protein 26 protein, from Human, contains 441 amino acids, has 4 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is E3 ubiquitin-protein ligase TRIM39 protein, from Human, contains 518 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251), Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251), Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554)


This is Platelet glycoprotein VI protein, from Human, contains 339 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Collagen receptor involved in collagen-induced platelet adhesion and activation, Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation, This procoagulant function may contribute to arterial and venous thrombus formation, The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2


This is Zinc finger protein 304 protein, from Human, contains 659 amino acids, has 16 C2H2-type Zinc finger.

Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979), Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306), Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner, Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306), Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979), Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979), Promotes angiogenesis (PubMed:26081979), Promotes tumor growth (PubMed:24623306, PubMed:26081979)


This is Macrophage colony-stimulating factor 1 receptor protein, from Zebrafish, contains 977 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, Plays an important role in innate immunity and in inflammatory processes, Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development, Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, Activates several signaling pathways in response to ligand binding (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Fibroblast growth factor receptor 3 protein, from Zebrafish, contains 800 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis, Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development, Regulates both osteogenesis and postnatal bone mineralization by osteoblasts, Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation, Phosphorylates PLCG1, CBL and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is E3 ubiquitin-protein ligase siah2 protein, from African clawed frog, contains 313 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Involved in eye morphogenesis, probably triggers the ubiquitin-mediated degradation of different substrates (PubMed:11335112), May play a role in the regulation of the cellular clock function (By similarity)

Belongs to the SINA (Seven in absentia) family


This is Mineralocorticoid receptor protein, from Rainbow trout, contains 359 amino acids, has 1 NR C4-type Zinc finger.

NR C4-type

Receptor for both mineralocorticoids (MC) such as cortisol, Binds to mineralocorticoid response elements (MRE) and transactivates target genes, The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity)


This is Estrogen receptor beta protein, from Channel catfish, contains 575 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner


This is Gag polyprotein protein, from HIV-1, contains 511 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Gag-Pro polyprotein protein, from MMTV, contains 860 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell


This is ICOS ligand protein, from Mouse, contains 322 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ligand for the T-cell-specific cell surface receptor ICOS, Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells, Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function, During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Transcription factor Sp5 protein, from Mouse, contains 398 amino acids, has 3 C2H2-type Zinc finger.

Binds to GC boxes promoters elements, Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Junctional adhesion molecule A protein, from Rat, contains 300 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Seems to play a role in epithelial tight junction formation, Appears early in primordial forms of cell junctions and recruits PARD3, The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly, Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier, Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration

Belongs to the immunoglobulin superfamily


This is Junctional adhesion molecule B protein, from Mouse, contains 298 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:16093349, PubMed:21868569, PubMed:24357068), Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:21868569, PubMed:24357068), At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:21868569, PubMed:24357068), Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:16297198, PubMed:19740376), Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:19740376), Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (Probable), Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (PubMed:27499083), During myogenesis, it is involved in myocyte fusion (By similarity), May also play a role in angiogenesis (PubMed:25911611)


This is E3 ubiquitin-protein ligase RNF14 protein, from Mouse, contains 485 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity), Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates ubiquitination of EEF1A1/eEF1A, leading to its degradation (By similarity), In addition to EEF1A1/eEF1A, RNF14 catalyzes ubiquitination of other translation factors on stalled ribosomes: mediates ubiquitination and degradation of ETF1/eRF1 and ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (By similarity), Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interation with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (By similarity), May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (By similarity), May regulate the expression of both mitochondrial and immune related genes in skeletal muscle (PubMed:24472305)

Belongs to the RBR family, RNF14 subfamily


This is E3 ubiquitin-protein ligase Hakai protein, from Mouse, contains 491 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (PubMed:11836526, PubMed:22252131), Targets CDH1 for endocytosis and degradation (PubMed:11836526), Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716), Its function in the WMM complex is unknown (PubMed:29535189, PubMed:29547716)


This is Pyrin protein, from Rat, contains 747 amino acids, has 1 B box-type Zinc finger.

B box-type

Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma, Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy, Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation, However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity), Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity), It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation, Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity)


This is Pyrin protein, from Mouse, contains 767 amino acids, has 1 B box-type Zinc finger.

B box-type

Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:34471287), Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (By similarity), Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity), However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity), Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (PubMed:34471287), It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (By similarity), Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity)


This is Zinc finger CCCH domain-containing protein 8 protein, from Mouse, contains 305 amino acids, has 3 C3H1-type Zinc finger.

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III, Acts as a transcriptional repressor of the GATA3 promoter, Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity), Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene


This is Hepatocyte growth factor-regulated tyrosine kinase substrate protein, from Rat, contains 776 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Involved in intracellular signal transduction mediated by cytokines and growth factors, When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF, Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin, May concentrate ubiquitinated receptors within clathrin-coated regions, Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex), The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes, Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity), May contribute to the efficient recruitment of SMADs to the activin receptor complex


This is THAP domain-containing protein 11 protein, from Mouse, contains 305 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells, Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers


This is DNA polymerase eta protein, from Mouse, contains 694 amino acids, has 1 UBZ3-type Zinc finger.

DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10871396), Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions, Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex, In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (By similarity), Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10871396), Although inserts the correct base, may cause base transitions and transversions depending upon the context, May play a role in hypermutation at immunoglobulin genes, Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue, This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis, Targets POLI to replication foci (By similarity)

Belongs to the DNA polymerase type-Y family


This is Krueppel-like factor 13 protein, from Mouse, contains 289 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage


This is Sodium channel subunit beta-3 protein, from Rat, contains 215 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Modulates channel gating kinetics, Causes unique persistent sodium currents, Inactivates the sodium channel opening more slowly than the subunit beta-1, Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons

Belongs to the sodium channel auxiliary subunit SCN3B (TC 8,A,17) family


This is Arf-GAP with dual PH domain-containing protein 2 protein, from Rat, contains 376 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for the ADP ribosylation factor family (Potential), Binds phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4), Binding of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4-bisphosphate occurs at a much lower affinity, Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity)


This is E3 ubiquitin-protein ligase parkin protein, from Rat, contains 465 amino acids, has 1 RING-type 0; atypical Zinc finger, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type 0; atypical

RING-type

IBR-type

RING-type 2; atypical

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, Substrates include SYT11 and VDAC1, Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2, Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context, Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation, Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation, Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy, Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components, Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy, Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin, After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis, When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30, Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy, The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2, This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes, Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma, Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A, Limits the production of reactive oxygen species (ROS), Regulates cyclin-E during neuronal apoptosis, In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress, Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53, May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity, May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis, May represent a tumor suppressor gene

Belongs to the RBR family, Parkin subfamily


This is Zinc finger and BTB domain-containing protein 32 protein, from Mouse, contains 465 amino acids, has 3 C2H2-type Zinc finger.

DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence, May function as a transcriptional transactivator and transcriptional repressor (By similarity), Probably exerts its repressor effect by preventing GATA3 from binding to DNA, May play a role in regulating the differentiation and activation of helper T-cells


This is Triggering receptor expressed on myeloid cells 3 protein, from Mouse, contains 183 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response


This is Triggering receptor expressed on myeloid cells 1 protein, from Mouse, contains 230 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses, Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12, In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma, This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:23241959, PubMed:27328755), By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity)


This is Nectin-1 protein, from Mouse, contains 515 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Involved in cell adhesion and synaptogegesis, Has some neurite outgrowth-promoting activity, Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells


This is Muscleblind-like protein 1 protein, from Mouse, contains 341 amino acids, has 4 C3H1-type Zinc finger.

Mediates pre-mRNA alternative splicing regulation, Acts either as activator or repressor of splicing on specific pre-mRNA targets, Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle, Antagonizes the alternative splicing activity pattern of CELF proteins, Regulates the TNNT2 exon 5 skipping through competition with U2AF2, Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA, Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly, Binds to the 5'-YGCU(U/G)Y-3'consensus sequence, Binds to the IR RNA, Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs (By similarity)


This is Zinc finger and BTB domain-containing protein 18 protein, from Rat, contains 522 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development, Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes, Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis, Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons, May also play a role in the organization of chromosomes in the nucleus (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily