This is GDNF-inducible zinc finger protein 1 protein, from Rat, contains 707 amino acids, has 10 C2H2-type Zinc finger.

Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'), May be regulating VSX2/HOX10 expression


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 5 protein, from Rat, contains 719 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Promotes neurite outgrowth in hippocampal neurons (By similarity)


This is E3 ubiquitin-protein ligase RNF152 protein, from Rat, contains 203 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation, Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability, Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation, Induces apoptosis when overexpressed


This is Zinc finger and BTB domain-containing protein 4 protein, from Rat, contains 984 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 5 C2H2-type Zinc finger.

C2H2-type 1; atypical

Transcriptional repressor with bimodal DNA-binding specificity, Represses transcription in a methyl-CpG-dependent manner, Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS), Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA, Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 4 protein, from Rat, contains 636 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Promotes neurite outgrowth in hippocampal neurons, May play a role in redistributing DLG4 to the cell periphery (By similarity)


This is E3 ubiquitin-protein ligase RNF146-A protein, from Bovine, contains 346 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex, Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2, Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity)


This is E3 ubiquitin-protein ligase TRIM56 protein, from Bovine, contains 732 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118), In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity), Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (By similarity), Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling, Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity), Restricts bovine viral diarrhea virus (BVDV) replication (PubMed:21289118)


This is Sharpin protein, from Bovine, contains 409 amino acids, has 1 RanBP2-type Zinc finger.

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation, LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways, Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation, LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex, The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria, LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin, The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation, Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis


This is E3 ubiquitin-protein ligase RNF152 protein, from Chicken, contains 203 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation, Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability, Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation


This is N-lysine methyltransferase SMYD2 protein, from Chicken, contains 436 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is RanBP-type and C3HC4-type zinc finger-containing protein 1 protein, from European seabass, contains 707 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity), LUBAC conjugates linear polyubiquitin to ikbkg and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity), Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity), LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) to conjugate linear polyubiquitin to ikbkg and possibly other components contributing to the stability of the complex (By similarity), The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity), LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity), The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity), Binds polyubiquitin of different linkage types (By similarity)


This is Peroxisome biogenesis factor 2 protein, from Zebrafish, contains 312 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane, PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity)


This is E3 ubiquitin-protein ligase RNF169 protein, from Zebrafish, contains 630 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage


This is Interferon regulatory factor 2-binding protein 2 protein, from Mouse, contains 570 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Acts as a transcriptional corepressor in a IRF2-dependent manner, this repression is not mediated by histone deacetylase activities, Represses the NFAT1-dependent transactivation of NFAT-responsive promoters, Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles, Plays a role in immature B-cell differentiation (By similarity)


This is Zinc finger protein 277 protein, from Mouse, contains 583 amino acids, has 2 C2H2-type Zinc finger.

Probable transcription factor (PubMed:20808772), Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1 (PubMed:20808772)


This is Zinc finger protein OBI1 protein, from Mouse, contains 680 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 8 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May modulate osteogenic differentiation, at least in part, through the bone morphogenetic protein (BMP) signaling pathway, increasing RUNX2 activation and leading to osteoblast commitment and maturation


This is RING finger protein 207 protein, from Zebrafish, contains 634 amino acids, has 1 RING-type Zinc finger, has 1 B box-type; atypical Zinc finger.

RING-type

B box-type; atypical

Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel kcnh6a/zerg, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner


This is Netrin receptor UNC5D protein, from Rat, contains 956 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for the netrin NTN4 that promotes neuronal cell survival, Plays a role in cell-cell adhesion and cell guidance, Receptor for netrin involved in cell migration, Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding, May play a role in apoptosis in response to DNA damage, It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity), Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity)


This is DBIRD complex subunit ZNF326 protein, from Bovine, contains 579 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions, May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro (By similarity)


This is E3 ubiquitin-protein ligase ZNRF1 protein, from Bovine, contains 227 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation, Plays a role in the establishment and maintenance of neuronal transmission and plasticity, Regulates Schwann cells differentiation by mediating ubiquitination of GLUL, Promotes degeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (By similarity)


This is E3 ubiquitin-protein ligase RNF169 protein, from Bovine, contains 689 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage, Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization, Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1, E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair


This is E3 ubiquitin-protein ligase RNF14 protein, from Zebrafish, contains 459 amino acids, has 2 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase that plays a key role in the rnf14-rnf25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity), Recruited to stalled ribosomes by the ribosome collision sensor gcn1 and mediates ubiquitination of eef1a1/eEF1A, leading to its degradation (By similarity), In addition to eef1a1/eEF1A, rnf14 catalyzes ubiquitination of other translation factors on stalled ribosomes (By similarity), Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interation with TCF transcription factors (tcf7/tcf1, tcf7l1/tcf3 and tcf7l2/tcf4) (PubMed:23449499)

Belongs to the RBR family, RNF14 subfamily


This is FCS-Like Zinc finger 12 protein, from Mouse-ear cress, contains 228 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is TITAN-like protein protein, from Mouse-ear cress, contains 421 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

Key regulator for endosperm and embryo nuclear divisions


This is Replication protein A 70 kDa DNA-binding subunit E protein, from Mouse-ear cress, contains 784 amino acids, has 1 C4-type Zinc finger.

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication, The activity of RPA is mediated by single-stranded DNA binding and protein interactions, Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity)

Belongs to the replication factor A protein 1 family


This is Probable E3 ubiquitin-protein ligase EDA40 protein, from Mouse-ear cress, contains 739 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable E3 ubiquitin-protein ligase involved in female gametophyte development, Required for fusion of polar nuclei in the embryo sac


This is FCS-Like Zinc finger 7 protein, from Mouse-ear cress, contains 126 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type


This is Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog protein, from Mouse-ear cress, contains 735 amino acids, has 1 RTR1-type Zinc finger.

Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation


This is E3 ubiquitin-protein ligase TRIM71 protein, from Western clawed frog, contains 814 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance, Binds to miRNAs and participates in post-transcriptional repression of transcripts, Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development


This is Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 protein, from Bovine, contains 608 amino acids, has 1 RTR1-type Zinc finger.

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes, Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity), Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity)


This is Ubiquitin carboxyl-terminal hydrolase 13 protein, from Western clawed frog, contains 846 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD)


This is Tripartite motif-containing protein 2 protein, from White-tufted-ear marmoset, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11, Plays a neuroprotective function, May play a role in neuronal rapid ischemic tolerance, Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity


This is Peroxisome assembly protein 12 protein, from Sporotrichum thermophile, contains 439 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is Zinc finger protein 809 protein, from Mouse, contains 402 amino acids, has 7 C2H2-type Zinc finger.

Transcription factor specifically required to repress retrotransposons in embryonic stem cells, Recognizes and binds retroviral DNA sequences from a large subset of mammalian retroviruses and retroelements and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:19270682)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is GATA-type transcription factor sreA protein, from Aspergillus nidulans, contains 549 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

GATA-type transcription repressor that regulates iron- acquisition genes through specific binding GATA sequence elements of target promoters (PubMed:9988696, PubMed:11555288), Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity) (PubMed:11555288), SreA targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis (PubMed:11555288, PubMed:12196195, PubMed:12487628)


This is Zinc finger protein ztf-6 protein, from Caenorhabditis elegans, contains 480 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Probable transcription factor, involved in regulation of dopamine neuron lineage specification (PubMed:29301976), May play a role in maintaining robustness of the Wnt/beta-catenin asymmetry pathway (PubMed:29301976)


This is Zwei Ig domain protein zig-4 protein, from Caenorhabditis elegans, contains 253 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement


This is Transcription factor ovo-like homolog lin-48 protein, from Caenorhabditis elegans, contains 280 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor (By similarity), Involved in development of the hindgut, the male tail, and the excretory duct cell (PubMed:10511553, PubMed:11532910, PubMed:12231624), Involved in modulating function of excretory duct cells (PubMed:14758362), Plays a role in left/right patterning of cell fates in the hindgut (PubMed:10511553, PubMed:11532910)


This is Zwei Ig domain protein zig-3 protein, from Caenorhabditis elegans, contains 251 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is Zwei Ig domain protein zig-1 protein, from Caenorhabditis elegans, contains 265 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons


This is Transcription factor elt-6 protein, from Caenorhabditis elegans, contains 367 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcription factor (PubMed:11532911, PubMed:24885717), Binds to the sequence 5'-TGATAA-3' in regulatory elements of target genes, such as lin-39 (PubMed:24885717), Involved in embryonic development and in vulval development in larvae, acting redundantly, at least in part, with egl-18 (PubMed:11532911, PubMed:14975731, PubMed:12399309, PubMed:24885717), Perhaps acting together with egl-18, may form a positive feedback loop to initiate and maintain lin-39 gene expression to ensure proper vulval precursor cell (VPC) fate specification (PubMed:24885717), Together with egl-18, acts as a downstream target of the Wnt/beta-catenin asymmetry pathway, required to adopt or maintain the seam cell fate (PubMed:23633508), Required in seam cells, acting redundantly with egl-18, to promote production of alae, expression of several seam-specific genes and maintenance of seam cells in an unfused state (PubMed:11532911, PubMed:23633508), Plays a role in longevity (PubMed:18662544), May form a transcriptional circuit with GATA factors egl-18 and elt-3 (PubMed:18662544)


This is Nuclear hormone receptor family member nhr-27 protein, from Caenorhabditis elegans, contains 353 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor (By similarity), Involved in lifespan extension in a manner dependent upon mitochondrial function (PubMed:24107417)

Belongs to the nuclear hormone receptor family


This is Paired zinc finger protein 1 protein, from Caenorhabditis elegans, contains 504 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger, has 1 C2H2-type 8; degenerate Zinc finger.

C2H2-type 3; degenerate

C2H2-type 6; degenerate

C2H2-type 8; degenerate

Possible transcriptional regulator (Probable), Involved in promoting segregation of chromosomes during meiosis, perhaps acting downstream of the let-60 RAS / mpk-1 MAPK signaling pathway (PubMed:17096596)


This is Low affinity immunoglobulin gamma Fc region receptor III-A protein, from Guinea pig, contains 254 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (Ref,3), Binds with intermediate affinity to both IgG2a and IgG2b, Can bind to IgG2a and IgG2b monomers, Does not display binding to IgG1 or IgG3 (By similarity), Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC), Confers protection to lethal influenza virus infection (By similarity), On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (By similarity), Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (By similarity), Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (By similarity), Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE), Binds with low affinity to both the a and b allotypes of IgE, Has also been shown to bind to IgE allotype a only but not to allotype b, Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes, Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (By similarity), Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821)


This is Zygote arrest protein 2.L protein, from African clawed frog, contains 307 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:22732570), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (PubMed:22732570)

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is Protein JOKA2 protein, from Potato, contains 862 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Autophagic substrate that functions as host autophagy cargo receptor (Probable), Requires ATG8 protein expression to be recognized as an autophagic substrate (Probable), Activates ATG8CL-mediated selective autophagy, and contributes to defense against the fungal pathogen Phytophtora infestans (PubMed:26765567, PubMed:29932422)


This is Melanophilin protein, from Cat, contains 569 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab effector protein involved in melanosome transport, Serves as link between melanosome-bound RAB27A and the motor protein MYO5A


This is Nuclear hormone receptor family member nhr-62 protein, from Caenorhabditis elegans, contains 515 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear hormone receptor (PubMed:23935515), Required for metabolic and physiologic responses associated with dietary-restriction-induced longevity (PubMed:23935515), Modulates triglyceride and lipid metabolism and autophagy, associated with dietary-restriction, probably acting via regulation of transcription of target genes (PubMed:23935515)


This is T-cell-specific surface glycoprotein CD28 protein, from Cat, contains 221 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival, Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation


This is Zinc finger matrin-type protein 3 protein, from Rat, contains 289 amino acids, has 3 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

Acts as a bona fide target gene of p53/TP53, May play a role in the TP53-dependent growth regulatory pathway, May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus


This is DNA-binding protein Ikaros protein, from Rainbow trout, contains 522 amino acids, has 6 C2H2-type Zinc finger.

Binds and activates the enhancer (delta-A element) of the CD3-delta gene, Functions in the specification and the maturation of the T-lymphocyte, Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development, Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Vitamin D3 receptor protein, from African clawed frog, contains 422 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells, Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR, The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity), Plays a central role in calcium homeostasis (By similarity), Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Zinc finger SWIM domain-containing protein sws1 protein, from Fission yeast, contains 209 amino acids, has 1 SWIM-type Zinc finger.

SWIM-type

Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents


This is Nuclear polyadenylated RNA-binding protein nab2 protein, from Fission yeast, contains 307 amino acids, has 3 C3H1-type Zinc finger.

Binds to polyadenylated RNA and single-stranded DNA, It may be involved not only in RNA processing but also in transcription regulation, Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions (By similarity)


This is DNA-directed RNA polymerase III subunit RPC10 protein, from Fission yeast, contains 109 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is Putative ubiquitin thioesterase otu1 protein, from Fission yeast, contains 329 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (By similarity), Has a role in meiosis


This is TRAF-type zinc finger domain-containing protein 1 protein, from Human, contains 582 amino acids, has 1 TRAF-type Zinc finger.

TRAF-type

Negative feedback regulator that controls excessive innate immune responses, Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways, May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation, May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity)


This is Putative transcription factor Ovo-like 1 protein, from Human, contains 267 amino acids, has 4 C2H2-type Zinc finger.

Putative transcription factor, Involved in hair formation and spermatogenesis, May function in the differentiation and/or maintenance of the urogenital system (By similarity)


This is E3 ubiquitin-protein ligase trim-21 protein, from Caenorhabditis elegans, contains 292 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase which catalyzes 'Lys-48'-linked polyubiquitination of ced-1, promoting its proteasomal degradation to maintain appropriate ced-1 levels for apoptotic cell clearance (PubMed:35929733), Acts together with E2 ubiquitin-conjugating enzyme ubc-21 (PubMed:35929733)


This is Protein tailless protein, from Fruit fly, contains 450 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity, This receptor binds to the consensus sequence [AG][AG]AAGTCAA, Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo, It may also play a role in the nervous system, The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains, Involved in the regulation of early eye development, In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Transcription initiation factor IIB protein, from Caenorhabditis elegans, contains 306 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II) (By similarity), Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (By similarity), Essential for early embryonic development (PubMed:11566890)


This is Nuclear hormone receptor family member nhr-60 protein, from Caenorhabditis elegans, contains 443 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor (Potential), Required for embryonic and larval morphogenesis and probably for seam cell positioning and migration


This is Ecdysone receptor protein, from Tobacco budworm moth, contains 576 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone, Binds to ecdysone response elements (ECRES) (By similarity)


This is Calcium-binding and coiled-coil domain-containing protein 2 protein, from Bovine, contains 450 amino acids, has 1 UBZ1-type Zinc finger.

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity), Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity), Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity), Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity), May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity)


This is CD226 antigen protein, from Rhesus macaque, contains 336 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell, Cell surface receptor for NECTIN2, Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG, Competes with PVRIG for NECTIN2-binding


This is Serine/threonine-protein kinase A-Raf protein, from Pig, contains 606 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus, May also regulate the TOR signaling cascade (By similarity), Phosphorylates PFKFB2 (By similarity)

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily


This is Zinc finger protein ZAT6 protein, from Mouse-ear cress, contains 238 amino acids, has 2 C2H2-type Zinc finger.

Probable transcription factor that regulates root development and phosphate (Pi) acquisition and homeostasis, Probably acts as a repressor of primary root growth and regulates Pi homeostasis through the control of root architecture


This is Zinc finger protein CONSTANS-LIKE 14 protein, from Mouse-ear cress, contains 402 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical


This is Cyclic dof factor 4 protein, from Mouse-ear cress, contains 170 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity), Transcriptional repressor of 'CONSTANS' expression (By similarity), Regulates a photoperiodic flowering response


This is Plant-specific TFIIB-related protein 1 protein, from Mouse-ear cress, contains 503 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

Plant-specific TFIIB-related protein that may be involved in an intracellular signaling pathway between plastids and the nucleus (PubMed:12697827), May act as general transcription factor (GTF) of RNA polymerase I-dependent transcription and rRNA synthesis, Forms a ternary complex with TBP2 and the rDNA promoter region (PubMed:18668124)


This is DNA topoisomerase 1 protein, from Methanobacterium thermoautotrophicum, contains 718 amino acids, has 2 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is DNA topoisomerase 1 protein, from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16), contains 663 amino acids, has 1 C4-type Zinc finger, has 1 C4-type 2; atypical Zinc finger.

C4-type 2; atypical


This is ATP-dependent Clp protease ATP-binding subunit ClpE protein, from Bacillus subtilis (strain 168), contains 699 amino acids, has 1 C4-type Zinc finger.

ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression, Together with ClpP, degrades the global regulator CtsR after heat shock, Is also involved in disaggregation of heat-denatured proteins, Has thus a role in overall protein quality control in response to heat stress

Belongs to the ClpA/ClpB family, ClpE subfamily


This is DNA topoisomerase 1 protein, from Fervidobacterium islandicum, contains 699 amino acids, has 1 C4-type Zinc finger.


This is Ras association domain-containing protein 5 protein, from Rat, contains 413 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Potential tumor suppressor, Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation, Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1, Together with RAP1A may participate in regulation of microtubule growth, The association with activated RAP1A is required for directional movement of endothelial cells during wound healing, May be involved in regulation of Ras apoptotic function, The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis (By similarity)


This is DnaJ homolog subfamily A member 2 protein, from Rat, contains 412 amino acids, has 1 CR-type Zinc finger.

CR-type

Co-chaperone of Hsc70, Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)


This is Zinc finger Ran-binding domain-containing protein 2 protein, from Rat, contains 330 amino acids, has 2 RanBP2-type Zinc finger.

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts, May interfere with constitutive 5'-splice site selection (By similarity)


This is Fibroblast growth factor receptor 3 protein, from African clawed frog, contains 802 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis, Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development, Regulates both osteogenesis and postnatal bone mineralization by osteoblasts, Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation, Phosphorylates PLCG1, CBL and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Estrogen receptor protein, from Red sea bream, contains 581 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Semaphorin-3C protein, from Chicken, contains 751 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Induces the collapse and paralysis of neuronal growth cones, Could potentially act as repulsive cues toward specific neuronal populations, Binds to neuropilin


This is Semaphorin-3E protein, from Chicken, contains 785 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Plays an important role in signaling via the cell surface receptor PLXND1, Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections, Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix, Regulates angiogenesis, Can down-regulate sprouting angiogenesis, Required for normal vascular patterning during embryogenesis, Induces the collapse and paralysis of neuronal growth cones, Plays an important role in ensuring the specificity of synapse formation (By similarity)


This is Thyroid hormone receptor alpha protein, from King penguin, contains 402 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine


This is 43 kDa receptor-associated protein of the synapse protein, from Chicken, contains 412 amino acids, has 1 RING-type Zinc finger.

RING-type

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction, It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity)


This is Thyroid hormone receptor alpha protein, from Adelie penguin, contains 402 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is MYND-type zinc finger protein samB protein, from Aspergillus nidulans, contains 590 amino acids, has 1 MYND-type; degenerate Zinc finger.

MYND-type; degenerate

Involved in determination of the onset of polarized growth and morphogenesis, Plays a role in the regulation of branching in hyphae and spore formation


This is Chromatin modification-related protein png1 protein, from Fission yeast, contains 283 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of a histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Has a role in silencing of mating type genes


This is Vacuolar protein-sorting-associated protein 36 protein, from Fission yeast, contains 467 amino acids, has 1 RanBP2-type 1; degenerate Zinc finger, has 1 RanBP2-type Zinc finger.

RanBP2-type 1; degenerate

Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation, The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex, Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (By similarity), Required for vacuolar sorting of carboxypeptidase S (CPS)


This is Zinc finger protein lsy-27 protein, from Caenorhabditis elegans, contains 250 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Involved in regulating left/right asymmetric differentiation of the gustatory ASE neurons (PubMed:21555395), Plays a role in modulating expression of LIM/homeobox protein lim-6 (PubMed:21555395)


This is Hepatitis A virus cellular receptor 1 protein, from Green monkey, contains 478 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity), As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses, Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity), Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10, Acts as regulator of T-cell proliferation (By similarity), May play a role in kidney injury and repair (By similarity)

Belongs to the immunoglobulin superfamily, TIM family


This is CD166 antigen protein, from Dog, contains 521 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts, Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity), Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity), Mediates homotypic interactions with cells that express ALCAM, Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction, Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions, Required for normal organization of the lymph vessel network, Required for normal hematopoietic stem cell engraftment in the bone marrow, Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow, Promotes in vitro osteoblast proliferation and differentiation (By similarity), Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity), Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)


This is CD166 antigen protein, from Rabbit, contains 521 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Formamidopyrimidine-DNA glycosylase protein, from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8), contains 267 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


This is Formamidopyrimidine-DNA glycosylase protein, from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), contains 269 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Zinc finger matrin-type protein 3 protein, from Mouse, contains 290 amino acids, has 3 Matrin-type Zinc finger.

Matrin-type

Matrin-type

Matrin-type

Acts as a bona fide target gene of p53/TP53, May play a role in the TP53-dependent growth regulatory pathway, May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus


This is DNA-directed RNA polymerase 30 kDa polypeptide protein, from VACV, contains 259 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates, Responsible for the transcription of early, intermediate and late genes, DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118/D6 and OPG134/A8, thereby allowing the early genes transcription, Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase

Belongs to the poxviridae DNA-directed RNA polymerase 30 kDa subunit family


This is DNA topoisomerase 1 protein, from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3), contains 686 amino acids, has 1 C4-type Zinc finger, has 1 C4-type 2; atypical Zinc finger.

C4-type 2; atypical

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is SWR1 complex subunit vps71 protein, from Fission yeast, contains 139 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A,Z leading to transcriptional regulation of selected genes by chromatin remodeling


This is Pre-mRNA-splicing factor sap61 protein, from Fission yeast, contains 492 amino acids, has 1 C2H2-type Zinc finger, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome


This is Methionine aminopeptidase 1 protein, from Fission yeast, contains 379 amino acids, has 1 C6H2-type Zinc finger.

Cotranslationally removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

Belongs to the peptidase M24A family, Methionine aminopeptidase type 1 subfamily


This is DNA repair protein rad14 protein, from Fission yeast, contains 289 amino acids, has 1  Zinc finger.

Involved in nucleotide excision repair (NER), Functional in repair of ultraviolet radiation induced damages and in mitotic mutation avoidance, Binds damaged DNA, Binds specifically to base-base mismatches or small insertion/deletion loops with unpaired nucleotides, Maintains GT repeat stability, Functions as a part of the short-patch excision repair system


This is Zinc finger protein 354A protein, from Human, contains 605 amino acids, has 13 C2H2-type Zinc finger.


This is DNA topoisomerase 3 protein, from Caenorhabditis elegans, contains 759 amino acids, has 1 GRF-type Zinc finger.

GRF-type

Component of the BTR double Holliday Junction dissolution complex, which is involved in homologous recombination during meiotic double strand break in the germline (Probable), Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)


This is Transcription factor elt-7 protein, from Caenorhabditis elegans, contains 198 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:26700680), Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-2 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527, PubMed:24257624), May have a protective role in response to infection by Gram-negative bacteria such as P,aeruginosa (PubMed:21168435)


This is Kruppel-like factor 2 protein, from Caenorhabditis elegans, contains 299 amino acids, has 3 C2H2-type Zinc finger.

Probable transcription factor which regulates lipid metabolism


This is Antigen-presenting glycoprotein CD1d protein, from Sheep, contains 335 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells


This is Zinc finger CCCH domain-containing protein 54 protein, from Mouse-ear cress, contains 245 amino acids, has 1 C3H1-type Zinc finger.

Embryo-specific transcription factor required at the globular to heart stage transition in embryo development


This is Zinc finger protein ZAT3 protein, from Mouse-ear cress, contains 284 amino acids, has 3 C2H2-type Zinc finger.

Mediates the regulation of male germ cell division by DUO1


This is Transcriptional repressor NrdR protein, from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145), contains 182 amino acids, has 1  Zinc finger.

Negatively regulates transcription of nrdRJ (class II RNR genes) and nrdABS operon (class I RNR genes) by binding to NrdR-boxes which are proximal to or overlap with the promoter regions of class II and class Ia RNR operons, respectively


This is Early growth response protein 1 protein, from Chicken, contains 194 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity), Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity), Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia, Plays a role in the regulation of cell survival, proliferation and cell death, Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity), Plays a role in regulating the expression of circadian clock genes (By similarity)

Belongs to the EGR C2H2-type zinc-finger protein family


This is Early growth response protein 1 protein, from Japanese quail, contains 194 amino acids, has 3 C2H2-type Zinc finger.


This is Early growth response protein 1 protein, from Zebra finch, contains 193 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity), Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity), Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia, Plays a role in the regulation of cell survival, proliferation and cell death, Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity), Plays role in regulating the expression of circadian clock genes (By similarity)


This is Early growth response protein 1 protein, from Island canary, contains 59 amino acids, has 3 C2H2-type Zinc finger.


This is Tapasin protein, from Chicken, contains 430 amino acids, has 2 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Ig-like C1-type

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)


This is Transcription factor steA protein, from Aspergillus nidulans, contains 692 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor involved in sexual reproduction, Required for cleistothecial development and ascosporogenesis, Not required for asexual reproduction (conidiation), May act to repress medA expression

Belongs to the STE12 transcription factor family


This is Set1 complex component spp1 protein, from Fission yeast, contains 424 amino acids, has 1 PHD-type Zinc finger.

PHD-type

The Set1 complex specifically methylates 'Lys-4' of histone H3


This is DNA-directed RNA polymerase II subunit RPB9 protein, from Fission yeast, contains 113 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity), Involved in the regulation of transcription elongation


This is Postreplication repair E3 ubiquitin-protein ligase rad18 protein, from Fission yeast, contains 387 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group, Associates to the E2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA (By similarity)


This is Vacuolar membrane protein pep3 protein, from Fission yeast, contains 900 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is General transcription and DNA repair factor IIH subunit ssl1 protein, from Fission yeast, contains 421 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription


This is Leucine-rich repeat neuronal protein 2 protein, from Human, contains 713 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type


This is Zinc finger protein 253 protein, from Human, contains 499 amino acids, has 11 C2H2-type Zinc finger.

May function as a transcription factor, Seem to have a transcriptional repression activity


This is Zinc finger protein 254 protein, from Human, contains 659 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 13 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 821 protein, from Human, contains 412 amino acids, has 2 C2H2-type Zinc finger.


This is Transcription elongation factor A protein 3 protein, from Human, contains 348 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus


This is Tripartite motif-containing protein 26 protein, from Pig, contains 545 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs) (PubMed:33086712), Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA, Promotes nuclear IRF3 ubiquitination and proteasomal degradation, Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1, Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signalings, In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation, Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein, Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity), Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity), Inhibitis Porcine reproductive and respiratory syndrome virus-2 by catalyzing the 'Lys-48'-linked polyubiquitination of the nucleocapsid protein N (PubMed:35077707)


This is FCS-Like Zinc finger 3 protein, from Mouse-ear cress, contains 93 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway


This is ADP-ribosylation factor GTPase-activating protein AGD7 protein, from Mouse-ear cress, contains 456 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF), Involved in protein trafficking by controlling ARF1 activity; may participate in COPI vesicle formation at the Golgi complex


This is PHD finger protein ALFIN-LIKE 4 protein, from Mouse-ear cress, contains 255 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Zinc finger protein CO3 protein, from Rice, contains 335 amino acids, has 1 B box-type; atypical Zinc finger.

B box-type; atypical

Probable transcription factor involved in the regulation of flowering time under short day (SD) conditions, Functions as repressor of flowering under SD conditions, independently of HD1, EHD1, MADS50 and MADS51, Controls flowering time under SD conditions by negatively regulating the expression of HD3A and FTL


This is Zinc finger protein CONSTANS-LIKE 13 protein, from Mouse-ear cress, contains 332 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical


This is B-box zinc finger protein 23 protein, from Mouse-ear cress, contains 162 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Probable transcription factor that may be involved in seedling photomorphogenesis


This is DNA topoisomerase 1 protein, from Treponema pallidum (strain Nichols), contains 731 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is Peroxisome assembly protein 12 protein, from Rat, contains 359 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is CD83 antigen protein, from Mouse, contains 196 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation


This is FYVE, RhoGEF and PH domain-containing protein 3 protein, from Mouse, contains 733 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Promotes the formation of filopodia, May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Plays a role in regulating the actin cytoskeleton and cell shape


This is E3 ubiquitin-protein ligase IE2 protein, from BmNPV, contains 422 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

RING-finger E3 ubiquitin ligase that plays an important regulatory role during the initial stages of infection, Migrates to specific nuclear foci early in infection supposely to prepare the sites for viral replication by targeting and ubiquitinating host proteins

Belongs to the alphabaculovirus IE2 protein family


This is Pro-neuregulin-1, membrane-bound isoform protein, from African clawed frog, contains 677 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Direct ligand for the ERBB tyrosine kinase receptors, Induces expression of acetylcholine receptor in synaptic nuclei


This is Estrogen receptor beta protein, from Japanese quail, contains 472 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner


This is NURS complex subunit pir2 protein, from Fission yeast, contains 609 amino acids, has 1 C2H2-type Zinc finger.


This is Endoplasmic reticulum junction formation protein lunapark protein, from Fission yeast, contains 334 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Plays a role in tubular endoplasmic reticulum network formation and maintenance


This is DNA-directed RNA polymerase I subunit RPA12 protein, from Fission yeast, contains 119 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I which synthesizes ribosomal RNA precursors, Required for growth at higher temperatures


This is Semaphorin-3D protein, from Human, contains 777 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Induces the collapse and paralysis of neuronal growth cones, Could potentially act as repulsive cues toward specific neuronal populations, Binds to neuropilin (By similarity)


This is Zinc finger protein 682 protein, from Human, contains 498 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 11; degenerate Zinc finger.

C2H2-type 11; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Immunoglobulin superfamily member 6 protein, from Human, contains 241 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type


This is Large ribosomal subunit protein eL43 protein, from Plasmodium falciparum (isolate 3D7), contains 96 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28288098), The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable), The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable), The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable)

Belongs to the eukaryotic ribosomal protein eL43 family


This is Probable replication factor A 73 kDa subunit protein, from Caenorhabditis briggsae, contains 658 amino acids, has 1 C4-type Zinc finger.

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress, It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism, Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage

Belongs to the replication factor A protein 1 family


This is Immunoglobulin kappa variable 1D-16 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin kappa variable 2D-40 protein, from Human, contains 121 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 3-15 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 1-40 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)


This is Immunoglobulin lambda variable 3-19 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 3-1 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 3-25 protein, from Human, contains 112 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin lambda variable 3-27 protein, from Human, contains 113 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 12-3 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is Immunoglobulin heavy variable 1-46 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin heavy variable 3-11 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-48 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-13 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-53 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 3-9 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 4-39 protein, from Human, contains 125 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin heavy variable 4-59 protein, from Human, contains 116 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Ig alpha chain C region protein, from Mouse, contains 344 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig alpha is the major immunoglobulin class in body secretions, It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system


This is Beta-2-microglobulin protein, from Bovine, contains 118 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system

Belongs to the beta-2-microglobulin family


This is RLA class I histocompatibility antigen, alpha chain 11/11 protein, from Rabbit, contains 361 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the presentation of foreign antigens to the immune system


This is H-2 class II histocompatibility antigen, E-D alpha chain protein, from Mouse, contains 255 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Antitermination protein Q protein, from Bacteriophage lambda, contains 207 amino acids, has 1  Zinc finger.

Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes (PubMed:18832144, PubMed:10384296, PubMed:31455742), Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP (PubMed:18832144), To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation (PubMed:10384296), Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes (PubMed:25092034)

Belongs to the phage antitermination Q type 2 family


This is Large T antigen protein, from JCPyV, contains 688 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription


This is Large T antigen protein, from MPyV, contains 785 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type


This is Large T antigen protein, from HaPyV, contains 751 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type

Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation, Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA, Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA, Participates in the modulation of cellular gene expression preceeding viral DNA replication, This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53, Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes, Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression, Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters, Initiates viral DNA replication and unwinding via interactions with the viral origin of replication, Binds two adjacent sites in the SV40 origin, The replication fork movement is facilitated by Large T antigen helicase activity, Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization, Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription (By similarity)


This is Small t antigen protein, from SV40, contains 174 amino acids, has 1 C4-type; atypical Zinc finger, has 1 H1C3-type; atypical Zinc finger.

C4-type; atypical

H1C3-type; atypical

Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle, Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit, Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters, Late during the infection cycle, ST may induce dephosphorylation of host eIF4E-binding protein EIF4EBP1 leading to the inhibition of cap-dependent translation, May establish and maintain high levels of viral genomes during persistent infection in cell culture


This is Secreted protein BARF1 protein, from HHV-4, contains 221 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1, May inhibit interferon secretion from mononuclear cells, Exhibits oncogenic activity in vitro


This is Gag polyprotein protein, from BLV, contains 392 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Binds strongly to viral nucleic acids and promote their aggregation, Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs


This is Gag polyprotein protein, from Avian erythroblastosis virus (strain ES4), contains 555 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Acts as a thyroid-hormone receptor antagonist, The v-ErbA oncogene cooperates with v-ErbB and other primarily sarcoma-inducing oncogenes in transformation of erythroblasts, It is non transforming by itself and cannot induce self-renewal of erythroblasts, Instead it blocks the residual capacity of the v-ErbB cells to differentiate terminally

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Outer capsid protein sigma-3 protein, from T3D, contains 365 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3

Belongs to the orthoreovirus sigma-3 protein family


This is T cell receptor gamma variable 3 protein, from Human, contains 118 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447), Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1, Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588), Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT, This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089), Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes, The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames, The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714)


This is Large T antigen protein, from LPV, contains 697 amino acids, has 1 T-ag D1-type Zinc finger.

T-ag D1-type


This is Protein E7 protein, from Human papillomavirus 11, contains 98 amino acids, has 1  Zinc finger.

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle, Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication, E7 protein has both transforming and trans-activating activities, Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes, Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation, Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha, Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta)

Belongs to the papillomaviridae E7 protein family


This is Intracisternal A-particle Pol-related polyprotein protein, from IAP-H18, contains 863 amino acids, has 1 Integrase-type Zinc finger.

Integrase-type

Belongs to the retroviral Pol polyprotein family


This is Immunoglobulin lambda variable 7-43 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is H-2 class II histocompatibility antigen, E-S beta chain protein, from Mouse, contains 232 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Immunoglobulin kappa variable 1-16 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447), Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes, In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells, Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414), The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain, Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen, The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170)


This is Immunoglobulin kappa variable 1D-39 protein, from Human, contains 117 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 3-11 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor beta variable 7-9 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is T cell receptor alpha variable 29/delta variable 5 protein, from Human, contains 119 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447), Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes, Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333), Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70, In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome, The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462), The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement, This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells, Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)


This is T-cell surface glycoprotein CD8 beta chain protein, from Rat, contains 208 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex, The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched, Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs), Additionally, plays a critical role in thymic selection of CD8+ T-cells


This is Large ribosomal subunit protein eL37B protein, from Fission yeast, contains 91 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL37 family


This is RLA class I histocompatibility antigen, alpha chain 19-1 protein, from Rabbit, contains 361 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Immunoglobulin kappa variable 2-30 protein, from Human, contains 120 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like


This is Immunoglobulin kappa variable 5-2 protein, from Human, contains 115 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like