This is E3 ubiquitin-protein ligase TRIM35 protein, from Human, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response, Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145), Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145), Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling, Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537), Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439)


This is Ubiquitin carboxyl-terminal hydrolase 22 protein, from Human, contains 525 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA, Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator, Recruited to specific gene promoters by activators such as MYC, where it is required for transcription, Required for nuclear receptor-mediated transactivation and cell cycle progression

Belongs to the peptidase C19 family, UBP8 subfamily


This is PHD finger protein 24 protein, from Human, contains 400 amino acids, has 1 PHD-type Zinc finger.

PHD-type


This is Zinc finger protein 148 protein, from Human, contains 794 amino acids, has 4 C2H2-type Zinc finger.

Involved in transcriptional regulation, Represses the transcription of a number of genes including gastrin, stromelysin and enolase, Binds to the G-rich box in the enhancer region of these genes

Belongs to the krueppel C2H2-type zinc-finger protein family


This is CENP-A multicopy suppressor protein 2 protein, from Fission yeast, contains 697 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

Required for proper chromosome segregation via regulation of CENP-A localization to the centromere


This is Zinc finger protein klf1 protein, from Fission yeast, contains 781 amino acids, has 2 C2H2-type Zinc finger.

Required for maintaining cell viability in nitrogen-deficient stationary phase (G0) cells


This is E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 protein, from Fission yeast, contains 205 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains, Involved in maintaining genome stability where it acts in the cellular response to DNA damage


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Fission yeast, contains 617 amino acids, has 1 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs and mRNAs (PubMed:34798057), Modifies the uridine in position 47 (U47) in the D-loop of tRNAs (PubMed:34798057), Also able to mediate formation of dihydrouridine outside of the D-loop of tRNAs (PubMed:34798057), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (PubMed:34798057), Dus3-mediated dihydrouridylation of the mRNA encoding alpha-tubulin nda2 is required for meiotic chromosome segregation (PubMed:34798057)

Belongs to the Dus family, Dus3 subfamily


This is NURS complex subunit red1 protein, from Fission yeast, contains 712 amino acids, has 1 C3H1-type Zinc finger.

Promotes the exosome-mediated degradation of mRNAs containing a DSR (determinant of selective removal) signal sequence from mitotic cells


This is pH-response transcription factor pacC/RIM101 protein, from Yeast, contains 661 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH, At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid-expressed genes, Specifically recognizes and binds the consensus sequence 5'-CCAAGAA-3', Required for the control of alkaline pH-induced filamentation (dimorphic switch) and virulence


This is ATP-dependent RNA helicase abstrakt protein, from Fruit fly, contains 619 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

ATP-dependent RNA helicase, Is essential for the directed and fasciculated early outgrowth of the bolwig nerves, as well as for its navigation at later stages, Is required during post-transcriptional gene expression, Plays a role during morphogenetic process, apoptosis and the establishment of cell polarity

Belongs to the DEAD box helicase family, DDX41 subfamily


This is DNA replication licensing factor Mcm6 protein, from Fruit fly, contains 817 amino acids, has 1 C4-type Zinc finger.

Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity Required for DNA replication and cell proliferation, Required for mitotic cycles, endocycles, and the special S phase associated with the amplification of chorion genes; has a role in origin unwinding or fork elongation at chorion loci


This is Protein wech protein, from Fruit fly, contains 832 amino acids, has 2 B box-type Zinc finger.

B box-type

B box-type

Vital for larval development, Plays a role in tumor formation, A crucial component for the physical link between integrins and the cytoskeleton in the epidermal muscle attachment sites


This is Longitudinals lacking protein, isoforms N/O/W/X/Y protein, from Fruit fly, contains 878 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is Longitudinals lacking protein, isoforms J/P/Q/S/Z protein, from Fruit fly, contains 963 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate


This is Protein pygopus protein, from Fruit fly, contains 815 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Involved in signal transduction through the Wnt pathway


This is Protein spindle-F protein, from Fruit fly, contains 364 amino acids, has 1 UBZ1-type Zinc finger.

Plays a role in oocyte axis determination and microtubule organization during oogenesis (PubMed:16540510, PubMed:24019068), Also required for polarized organization of the bristle (PubMed:19917727), Required, with jvl, for activation of the kinase IKKepsilon in the germ line (PubMed:24019068), Also required for localization of IKKepsilon to the distal tip of elongating bristles by acting as an adapter linking IKKepsilon and cytoplasmic dynein (PubMed:26092846), Involved in dendrite pruning in larval sensory neurons during metamorphosis (PubMed:26540204)


This is E3 ubiquitin-protein ligase RING1 protein, from Fruit fly, contains 435 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation, H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression, Polycomb group (PcG) protein, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, PcG complexes act via modification of histones, such as methylation, deacetylation, ubiquitination rendering chromatin heritably changed in its expressibility, May play a role in meiotic sister chromatid cohesion


This is Nuclear protein localization protein 4 homolog protein, from Fruit fly, contains 652 amino acids, has 1 RanBP2-type Zinc finger.

May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome


This is Cilium assembly protein DZIP1L protein, from Fruit fly, contains 737 amino acids, has 1 C2H2-type Zinc finger.

Component of the DZIP1-Fam92-Cby complex which promotes ciliogenesis in sensory neurons and spermatocytes by acting downstream of Cep290 to initiate early ciliary membrane formation and thus transition zone (TZ) assembly (PubMed:31821146, PubMed:33370260), During spermatogenesis, also regulates distal elongation of the basal-body and their docking (anchoring) to the plasma membrane and as a consequence, regulates the initiation and proper elongation of axonemal microtubules (PubMed:31821146), Within the complex, required to recruit or stabilize Rab8, Fam92 and Cby at the distal basal body of cilia to promote early ciliary membrane formation and initiate TZ assembly (PubMed:31821146), Also acts with Fam92 to restrict cep290 localization to the proximal part of the TZ (PubMed:31821146), May also be involved in recruitment or stabilization of Mks1 at the TZ (PubMed:31821146)

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole

Belongs to the DZIP C2H2-type zinc-finger protein family


This is Zinc finger protein squeeze protein, from Fruit fly, contains 535 amino acids, has 5 C2H2-type Zinc finger.

Transcription factor involved in neuronal fate specification, First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons, Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells, Also required for projection neuron dendritic targeting


This is Ubiquitin thioesterase trabid protein, from Fruit fly, contains 778 amino acids, has 3 RanBP2-type Zinc finger.

Positive regulator of the Wnt signaling pathway, Specifically cleaves 'Lys-63'-linked ubiquitin chains, May act by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription (By similarity), Required for an efficient wg response, but not for other signaling responses, in the eye


This is Polycomb protein Scm protein, from Fruit fly, contains 877 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Polycomb group (PcG) protein, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility


This is Ichor protein, from Fruit fly, contains 592 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional activator, In tracheal terminal cells, regulates the transcription of factors involved in the formation of a mature apical extracellular matrix (aECM) which is essential for the integrity and shape of seamless tubes


This is Transcription factor Ouib protein, from Fruit fly, contains 312 amino acids, has 5 C2H2-type Zinc finger.

Transcription factor required for ecdysteroid production in the prothoracic gland by activating transcription of the ecdysteroid biosynthesis gene spok, Binds to the 5'-AGCTTTATTATTTAG-3' DNA sequence in the spok enhancer region


This is E3 ubiquitin-protein ligase Godzilla protein, from Fruit fly, contains 536 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Endosomal E3 ubiquitin-protein ligase that regulates the recycling endosome pathway by mediating ubiquitination of Synaptobrevin (Syb) (PubMed:23353890), Also acts as a regulator of transcytosis in wing imaginal disks by catalyzing ubiquitination of Syb: ubiquitination of Syb promotes transcytosis of wingless (wg) to the basolateral surface (PubMed:26974662)


This is Zinc finger protein rotund protein, from Fruit fly, contains 946 amino acids, has 6 C2H2-type Zinc finger.

Transcription factor involved in imaginal disks development, Isoform rn is required in the wings, antenna, haltere, proboscis and legs disks, while isoform roe is required in the eye disk, Together with nab corepressor, it is involved in the initiation and maintenance of wingless (wg) expression in the wing hinge, by limiting the expression of wg to this compartment, Also required for the epithelial-mesenchymal transition branch of basolateral junctions signaling


This is Zinc finger protein weckle protein, from Fruit fly, contains 470 amino acids, has 6 C2H2-type Zinc finger.

Acts as an adapter to assemble/stabilize a Toll/wek/Myd88/tube complex; required for efficient recruitment of Myd88 to Toll, Dispensable for innate immune response; plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi, Involved in dorsoventral axis determination


This is Zinc finger protein Elbow protein, from Fruit fly, contains 553 amino acids, has 1 C2H2-type Zinc finger.

May negatively regulate Notch-induced cell proliferation in the eye-head primordium, May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation, Required for tracheal development


This is Interference hedgehog protein, from Fruit fly, contains 886 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc)

Belongs to the immunoglobulin superfamily, IHOG family


This is Protein dissatisfaction protein, from Fruit fly, contains 691 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' (PubMed:11977984), Acts as a transcriptional repressor (PubMed:11977984), In both females and males, functions downstream of tra2 to regulate the development and function of certain sex-specific abdominal neurons, and likely regulates the development and/or function of the nervous system that controls courtship behaviors involved in the recognition and response of adults to appropriate sexual partners (PubMed:9883729, PubMed:9023356, PubMed:11977984), In males, promotes abdominal motor neuronal innervation of the ventral muscles of abdominal segment 5 which is required for correct abdominal curling during copulation (PubMed:9883729, PubMed:9023356), In females, also promotes abdominal motor neuronal innervation but on the uterine muscles which is required for egg laying (PubMed:9883729, PubMed:9023356)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is DNA polymerase eta protein, from Fruit fly, contains 885 amino acids, has 2 UBZ3-type Zinc finger.

DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:11297519), Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11297519), Inserts one or 2 nucleotide(s) opposite the lesion (PubMed:11297519), During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase PolZ1/DNApol-zeta to initiate repair synthesis that is completed by end joining or another polymerase that can bind and reinitiate synthesis (PubMed:22532806), Particularly important for the repair of UV-induced pyrimidine dimers and for hydroxyurea (HU)-induced DNA damage (PubMed:22532806, PubMed:24553286), Although inserts the correct base, may cause base transitions and transversions depending upon the context (By similarity), Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue (By similarity), This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (By similarity)

Belongs to the DNA polymerase type-Y family


This is Protein mushroom body miniature protein, from Fruit fly, contains 539 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Required for small ribosomal subunit biogenesis in neuroblasts (PubMed:24615015), Plays a role in mushroom body development (PubMed:15375215)


This is Peroxisome assembly protein 12 protein, from Fruit fly, contains 297 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:21669930), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity), When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)


This is Zinc finger protein chinmo protein, from Fruit fly, contains 604 amino acids, has 2 C2H2-type Zinc finger.

Required for morphological differentiation of postmitotic neurons during postembryonic brain development (PubMed:17055440), Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage (PubMed:17055440), Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye-antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis (PubMed:20412771), In the adult testis, maintains the male identify of adult somatic cyst stem cells (PubMed:25453558, PubMed:29389999), Represses expression and alternative splicing of transformer pre-mRNA, resulting in the production of the male-specific isoform of transcription factor dsx which ensures male-specific transcription of target genes (PubMed:25453558, PubMed:29389999), Plays a role in actin nuclear localization through its involvement in repressing the expression of the kinase Cdi (PubMed:26021350), This maintains the cofilin/actin-depolymerizing factor homolog tsr in its unphosphorylated state which is required for actin nuclear import (PubMed:26021350)


This is Fez family zinc finger protein erm protein, from Fruit fly, contains 611 amino acids, has 6 C2H2-type Zinc finger.

Zinc-finger transcriptional repressor (PubMed:24550111, PubMed:24618901, PubMed:28245922), In larval brain, involved in the maintenance of cell fate of intermediate neural progenitors (INPs) that derive from type II neuroblasts (PubMed:20152183, PubMed:24618901, PubMed:27151950, PubMed:27510969, PubMed:28245922, PubMed:28899667), Restricts INP developmental potential and dedifferentiation by interacting with HDAC3 and the chromatin remodeling Brahma-associated protein (BAP) complex (PubMed:24618901, PubMed:24550111, PubMed:27151950, PubMed:28899667, PubMed:28245922), Restricts INP proliferation by regulating neuroblast specific factors such as prospero, pnt and grh, and by antagonizing the function of self-renewal factors, such as klu, dpn and E(spl)mgamma-HLH (PubMed:20152183, PubMed:24550111, PubMed:28899667), In the optic lobe, essential for coordinating the innervation/ targeting of the L3 and R8 axons to the M3 layer of the medulla (PubMed:29513217), Early in medulla development, functions in parallel to CadN and Sema1a pathways to promote targeting of the L3 growth cones to the proximal domain of the outer medulla possibly by controlling the expression of various cell surface genes such as dpr1 and dpr17 which function in L3 growth cone targeting (PubMed:29513217), Then once L3 growth cones segregate into the developing M3 layer, it activates the expression of netrins NetA and NetB which act locally to promote the attachment of R8 growth cones within the M3 layer (PubMed:29513217)


This is Protein drumstick protein, from Fruit fly, contains 81 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Putative transcription factor, May function redundantly with odd and sob in leg joint formation during the larval stages, acting downstream of Notch activation, Acts in a hierarchy during foregut and hindgut patterning and morphogenesis, antagonizing lin to relieve the repressive effect on bowl, Involved in cell rearrangement during elongation of the embryonic hindgut, Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut, Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus


This is Protein bowel protein, from Fruit fly, contains 744 amino acids, has 5 C2H2-type Zinc finger.

Putative transcription factor, Required for leg joint formation, acting downstream of Notch to pattern the leg tarsal segments, Functions in the terminal pathway during embryogenesis, acting downstream of tll in the posterior of the embryo, Acts in a hierarchy downstream of drm and lin during foregut and hindgut patterning and morphogenesis, Involved in cell rearrangement during elongation of the embryonic hindgut, Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut, Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus


This is Zinc finger protein Paris protein, from Fruit fly, contains 346 amino acids, has 8 C2H2-type Zinc finger.

Transcription repressor that inhibits transcription of srl/PGC-1-alpha to negatively regulate mitochondrial biogenesis and thereby promotes neurodegeneration (PubMed:27819722, PubMed:32138754), In neurons, functions downstream of the Pink1-park pathway and is likely to act as part of the Pink1-park homeostatic mechanism that maintains mitochondrial quality and function through degradation (mitophagy) and synthesis (biogenesis) (PubMed:32138754)


This is Protein lin-28 homolog protein, from Fruit fly, contains 195 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Zinc finger MYND domain-containing protein 10 homolog protein, from Fruit fly, contains 451 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a role in axonemal structure organization and motility, May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility


This is Ubiquitin carboxyl-terminal hydrolase nonstop protein, from Fruit fly, contains 496 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA, Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes, Required to counteract heterochromatin silencing, Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe, Required for expression of ecdysone-induced genes such as br/broad


This is SAGA-associated factor 11 homolog protein, from Fruit fly, contains 196 amino acids, has 1 SGF11-type Zinc finger.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination, Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B, The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription, Required for nuclear receptor-mediated transactivation, Binds independently on SAGA to promoters in an RNA-dependent manner, Binds to mRNA and is essential for total mRNA export from the nucleus, Required to counteract heterochromatin silencing, Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe, Required for expression of ecdysone-induced genes such as br/broad


This is Mitochondrial E3 ubiquitin protein ligase 1 protein, from Fruit fly, contains 338 amino acids, has 1 RING-type Zinc finger.

RING-type

Exhibits weak E3 ubiquitin-protein ligase activity, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, Plays a role in the control of mitochondrial morphology by promoting mitochondrial fission, Negatively regulates the mitochondrial fusion protein marf by promoting its ubiquitination, acting in a pathway that is parallel to the park/pink1 regulatory pathway


This is Dendritic arbor reduction protein 1 protein, from Fruit fly, contains 751 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator which promotes dendrite growth by suppressing, either directly or indirectly, the expression of the microtubule-severing protein spas (PubMed:21368042), Determines multipolar neuron morphology in postmitotic neurons by positively regulating the expression of genes involved in nuclear positioning including several dynein genes and the nuclear migration protein nudC (PubMed:26490864)


This is RING-box protein 1A protein, from Fruit fly, contains 108 amino acids, has 1 RING-type Zinc finger.

RING-type

Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription, Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate, Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex (PubMed:12062088), During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890), The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555), Also part of an SCF complex required for caspase activation during sperm differentiation (Probable)


This is Semaphorin-3ab protein, from Zebrafish, contains 778 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite


This is Semaphorin-3D protein, from Zebrafish, contains 764 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May play a role in the guidance of several axon pathways


This is Semaphorin-3aa protein, from Zebrafish, contains 860 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May influence outgrowth by a variety of growth cones including those of the posterior lateral line ganglion


This is Gag polyprotein protein, from HIV-1, contains 497 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


CCHC-type

CCHC-type


This is Endogenous retrovirus group K member 19 Pol protein protein, from Human, contains 959 amino acids, has 1 Integrase-type Zinc finger.

Integrase-type

Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA, The RNase H domain of the reverse transcriptase performs two functions, It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid, Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome, Endogenous Pol proteins may have kept, lost or modified their original function during evolution

Belongs to the beta type-B retroviral polymerase family, HERV class-II K(HML-2) pol subfamily


This is Putative transcription factor Ovo-like 1 protein, from Mouse, contains 267 amino acids, has 4 C2H2-type Zinc finger.

Putative transcription factor, Involved in hair formation and spermatogenesis, May function in the differentiation and/or maintenance of the urogenital system


This is Protein kinase C theta type protein, from Rat, contains 707 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2, In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1, May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway, In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling, Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization, After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR, During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells, May play a minor role in Th1 response, Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways, In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction, May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex, May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway, Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol (By similarity), Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1 (By similarity), Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Serine/threonine-protein kinase D1 protein, from Rat, contains 918 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10412981, PubMed:15514163, PubMed:15367659), Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation, Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS), Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway, In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane, May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface, Under oxidative stress, is phosphorylated at Tyr-469 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1, Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion, In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2, In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells (PubMed:18784310), May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression, Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway, Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:15367659), Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics, The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation, In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration, During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents, In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines, Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity), May play a role in inflammatory response by mediating activation of NF-kappa-B, May be involved in pain transmission by directly modulating TRPV1 receptor, Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (By similarity), Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S,enterica infection (By similarity)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is E3 ubiquitin-protein ligase RLIM protein, from Mouse, contains 600 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex, Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM, Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1, By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals


This is RING-box protein 2 protein, from Mouse, contains 113 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity), CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity), Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate, Promotes the neddylation of CUL5 via its interaction with UBE2F, May play a role in protecting cells from apoptosis induced by redox agents (By similarity)


This is Lipolysis-stimulated lipoprotein receptor protein, from Rat, contains 593 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Probable role in the clearance of triglyceride-rich lipoprotein from blood, Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (PubMed:10224102), Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity)

Belongs to the immunoglobulin superfamily, LISCH7 family


This is RanBP-type and C3HC4-type zinc finger-containing protein 1 protein, from Mouse, contains 508 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates, Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination, Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome, Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation, LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways, Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation, LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex, The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria, LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin, The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation, Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis, Binds polyubiquitin of different linkage types


This is Tripartite motif-containing protein 10 protein, from Mouse, contains 489 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells (PubMed:18560381), May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (PubMed:32343488), In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity, Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (By similarity)


This is Semaphorin-4G protein, from Mouse, contains 837 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB2, May play a role in axon guidance


This is Zinc finger and BTB domain-containing protein 18 protein, from Mouse, contains 522 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development, Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes, Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis, Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons, May also play a role in the organization of chromosomes in the nucleus

Belongs to the krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily


This is Programmed cell death 1 ligand 2 protein, from Mouse, contains 247 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner, Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Beta-2-microglobulin protein, from Chinese hamster, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system (By similarity)

Belongs to the beta-2-microglobulin family


This is E3 ubiquitin-protein ligase MARCHF7 protein, from Mouse, contains 693 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity), May be involved in T-cell proliferation by regulating LIF secretion (PubMed:15670816), May play a role in lysosome homeostasis (By similarity)


This is Prostaglandin F2 receptor negative regulator protein, from Mouse, contains 879 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant, Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity), In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration


This is Protein odd-skipped-related 1 protein, from Mouse, contains 266 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development

Belongs to the Odd C2H2-type zinc-finger protein family


This is MORC family CW-type zinc finger protein 1 protein, from Mouse, contains 950 amino acids, has 1 CW-type Zinc finger.

CW-type

Required for spermatogenesis (PubMed:10369865, PubMed:25503965), Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (PubMed:25503965), Not required for piRNA biosynthesis (PubMed:25503965)


This is Rac GTPase-activating protein 1 protein, from Mouse, contains 628 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis, Required for proper attachment of the midbody to the cell membrane during cytokinesis, Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity, Has a critical role in erythropoiesis (By similarity), Also involved in the regulation of growth-related processes in adipocytes and myoblasts, May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation, Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA, Essential for the early stages of embryogenesis, May play a role in regulating cortical activity through RHOA during cytokinesis, May participate in the regulation of sulfate transport in male germ cells


This is Inducible T-cell costimulator protein, from Mouse, contains 200 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells, Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens, Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10, Prevents the apoptosis of pre-activated T-cells, Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)


This is E3 ubiquitin-protein ligase parkin protein, from Mouse, contains 464 amino acids, has 1 RING-type 0; atypical Zinc finger, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type 0; atypical

RING-type

IBR-type

RING-type 2; atypical

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:32047033, PubMed:29311685), Substrates include SYT11 and VDAC1 (PubMed:32047033, PubMed:29311685), Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (By similarity), Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:32047033, PubMed:25474007), Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (By similarity), Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (By similarity), Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (By similarity), Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:32047033, PubMed:25474007, PubMed:22082830, PubMed:24898855), Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:32047033, PubMed:22082830, PubMed:24898855), Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:25474007), After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033), When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:21753002), Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (By similarity), The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:24192653), This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (By similarity), Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (By similarity), Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (By similarity), Limits the production of reactive oxygen species (ROS) (By similarity), Regulates cyclin-E during neuronal apoptosis (By similarity), In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830), Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972), May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (By similarity), May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis, May represent a tumor suppressor gene (By similarity)

Belongs to the RBR family, Parkin subfamily


This is Protein BUNDLE SHEATH DEFECTIVE 2, chloroplastic protein, from Maize, contains 129 amino acids, has 1 CR-type Zinc finger.

CR-type

Chloroplast chaperone required for RuBisCo complex biogenesis and translational regulation of the RuBisCo large subunit (RbcL) (PubMed:10330470, PubMed:12239405), Stabilizes an end-state assembly intermediate of eight RbcL subunits until the small subunits (RBCSs) become available to produce a complete stable RuBisCo complex containing eight small and eight large subunits (By similarity), Involved in the differentiation of bundle sheath cells, especially chloroplast structure (PubMed:12239405)


This is Axial regulator YABBY 3 protein, from Mouse-ear cress, contains 240 amino acids, has 1 C4-type Zinc finger.

Involved in the abaxial cell fate determination during embryogenesis and organogenesis, Regulates the initiation of embryonic shoot apical meristem (SAM) development (PubMed:10457020, PubMed:12417699, PubMed:19837869), Contributes to the repression of KNOX genes (STM, KNAT1/BP and KNAT2) to avoid ectopic meristems, Binds DNA without sequence specificity (PubMed:10457020, PubMed:12417699)


This is Estrogen receptor beta protein, from Bovine, contains 527 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, Binds estrogens with an affinity similar to that of ESR1ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Zinc finger protein mex-5 protein, from Caenorhabditis elegans, contains 468 amino acids, has 2 C3H1-type Zinc finger.

Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos (PubMed:10882103, PubMed:18199581, PubMed:18842813, PubMed:30279189), Also affects formation of intestinal cells (PubMed:10882103), Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA (PubMed:27594427), Required for neg-1 expression in anterior blastomeres during embryogenesis (PubMed:26096734)


This is Serine/threonine-protein kinase dkf-1 protein, from Caenorhabditis elegans, contains 722 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC (PubMed:16613841, PubMed:16613842), Role in the regulation of growth and neuromuscular control of movement (PubMed:16613841, PubMed:16613842), Involved in immune response to S,aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1 (PubMed:27184844)


This is Nuclear hormone receptor family member nhr-67 protein, from Caenorhabditis elegans, contains 416 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor that binds DNA containing an extended core motif half-site sequence 5'-AAGTCA-3' (PubMed:18179707, PubMed:19906858), In males, plays an essential role in the migration of the linker cell which guides gonad elongation during the L3 and L4 stages of larval development by negatively regulating the expression of netrin receptor unc-5 at the mid-L3 stage (PubMed:22363008, PubMed:19906858), Involved in the regulation of non-apoptotic cell death in the linker cell, acting upstream of or in parallel to transcription factor hsf-1 (PubMed:27472063)

Belongs to the nuclear hormone receptor family


This is Specificity protein transcription factor 3 protein, from Caenorhabditis elegans, contains 412 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor (PubMed:21884786, PubMed:23851392), Binds to GC-rich DNA motifs, such as 5'-GGGCGGGG-3' (PubMed:21884786, PubMed:23851392), Involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, by transcriptionally activating target genes, such as cell death activator egl-1 and leucine zipper kinase pig-1, in caspase-dependent and -independent apoptotic pathways (PubMed:23851392), Plays a role in the regulation of apoptosis, cell lineage, cell differentiation, embryonic morphogenesis, vulval development, and oocyte production (PubMed:21884786, PubMed:23851392, PubMed:26434722)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Arf-GAP with ANK repeat and PH domain-containing protein cnt-1 protein, from Caenorhabditis elegans, contains 826 amino acids, has 1 C4-type Zinc finger.

Truncated cnt-1: Promotes apoptosis during embryonic development, Produced by caspase ced-3-mediated cleavage, and translocates to the plasma membrane where it prevents the activation of the prosurvival Akt-1/2 and sgk-1 signaling pathway by competing with Akt-1/2 for the binding to PtdIns(3,4,5)P3


This is Hunchback-like protein protein, from Caenorhabditis elegans, contains 982 amino acids, has 9 C2H2-type Zinc finger.

Required for the late stages of development (PubMed:9917360), Plays a role in the developmental timing of postembryonic hypodermal seam cell fusion events and adult alae production (PubMed:28933985, PubMed:21471153)

Belongs to the hunchback C2H2-type zinc-finger protein family


This is Dystrobrevin-1 protein, from Caenorhabditis elegans, contains 590 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance

Belongs to the dystrophin family, Dystrobrevin subfamily


This is RING finger protein 24 protein, from Human, contains 148 amino acids, has 1 RING-type Zinc finger.

RING-type

May play a role in TRPCs intracellular trafficking


This is Transcription factor 19 protein, from Human, contains 345 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression


This is E3 ubiquitin-protein ligase RNF6 protein, from Human, contains 685 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation, Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover, Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity, May also bind DNA and function as a transcriptional regulator


This is DNA polymerase eta protein, from Human, contains 713 amino acids, has 1 UBZ3-type Zinc finger.

DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261), Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions, Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex, In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906), Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006), Although inserts the correct base, may cause base transitions and transversions depending upon the context, May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526), Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue, This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940), Targets POLI to replication foci (PubMed:12606586)


This is V-set and immunoglobulin domain-containing protein 4 protein, from Human, contains 399 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production, Potent inhibitor of the alternative complement pathway convertases


This is Sialic acid-binding Ig-like lectin 7 protein, from Human, contains 467 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid, Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide), The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface, In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules, Mediates inhibition of natural killer cells cytotoxicity, May play a role in hemopoiesis, Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is E3 ubiquitin-protein ligase DTX4 protein, from Human, contains 619 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity), Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4


This is Rabphilin-3A protein, from Human, contains 694 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity), At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity), In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability, Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity)

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane


This is Zinc finger and BTB domain-containing protein 1 protein, from Human, contains 713 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 UBZ-type Zinc finger, has 5 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

UBZ-type

Acts as a transcriptional repressor (PubMed:20797634), Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167), In addition, has a role in translesion DNA synthesis, Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165), Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity)


This is Ubiquitin carboxyl-terminal hydrolase 20 protein, from Human, contains 914 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085), Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314), Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882), Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085), Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117), Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2)(PubMed:19424180), Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2, Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180), This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins, Deubiquitinates DIO2, thereby regulating thyroid hormone regulation, Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016), Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767), Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613)

Belongs to the peptidase C19 family, USP20/USP33 subfamily


This is Zinc finger protein 835 protein, from Human, contains 537 amino acids, has 14 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein 256 protein, from Human, contains 627 amino acids, has 15 C2H2-type Zinc finger.

Transcriptional repressor that plays a role in cell proliferation, Requires TRIM28 for its activity


This is ARF GTPase-activating protein GIT1 protein, from Human, contains 761 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1, Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity), Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601), Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400), May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197), May act as scaffold for MAPK1/3 signal transduction in focal adhesions, Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189), Plays a role in brain development and function, Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity), Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193), In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane, These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502), May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity), In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity), In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783), May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity), Required for successful bone regeneration during fracture healing (By similarity), The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity), May play a role in angiogenesis during fracture healing (By similarity), In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302), Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721)


This is Zinc finger protein 281 protein, from Human, contains 895 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation, Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones, Not required for establishement and maintenance of ESCs (By similarity), Represses the transcription of a number of genes including GAST, ODC1 and VIM, Binds to the G-rich box in the enhancer region of these genes


This is DNA-directed RNA polymerase III subunit RPC10 protein, from Human, contains 108 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170), Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:12391170, PubMed:30584594), Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses (PubMed:19631370, PubMed:19609254), Acts as nuclear and cytosolic DNA sensor involved in innate immune response (PubMed:19631370, PubMed:19609254), Can sense non-self dsDNA that serves as template for transcription into dsRNA (PubMed:19631370, PubMed:19609254), The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19631370, PubMed:19609254)

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is Zinc finger and BTB domain-containing protein 32 protein, from Human, contains 487 amino acids, has 3 C2H2-type Zinc finger.

DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence, May function as a transcriptional transactivator and transcriptional repressor, Probably exerts its repressor effect by preventing GATA3 from binding to DNA, May play a role in regulating the differentiation and activation of helper T-cells (By similarity)


This is Krueppel-like factor 13 protein, from Human, contains 288 amino acids, has 3 C2H2-type Zinc finger.

Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1, It also represses transcription by interacting with the corepressor Sin3A and HDAC1, Activates RANTES expression in T-cells


This is Sialic acid-binding Ig-like lectin 9 protein, from Human, contains 463 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface


This is RING finger protein 11 protein, from Human, contains 154 amino acids, has 1 RING-type Zinc finger.

RING-type

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways, Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains, This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B, Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome


This is Zinc finger protein 337 protein, from Human, contains 751 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 19 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Zinc finger protein 330 protein, from Human, contains 320 amino acids, has 4 C4-type Zinc finger.


This is Pygopus homolog 1 protein, from Human, contains 419 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Involved in signal transduction through the Wnt pathway


This is Zinc finger protein 711 protein, from Human, contains 761 amino acids, has 11 C2H2-type Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger.

C2H2-type 6; degenerate

Transcription regulator required for brain development (PubMed:20346720), Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806), May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806)


This is Nuclear receptor subfamily 2 group E member 1 protein, from Human, contains 385 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity), May be required to pattern anterior brain differentiation, Involved in the regulation of retinal development and essential for vision, During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity), May be involved in retinoic acid receptor (RAR) regulation in retinal cells

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Lethal(3)malignant brain tumor-like protein 1 protein, from Human, contains 840 amino acids, has 1 CCHHC-type Zinc finger.

CCHHC-type

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications, PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription, Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes, Also recognizes and binds RB1/RB monomethylated at 'Lys-860', Participates in the ETV6-mediated repression, Probably plays a role in cell proliferation, Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis


This is Zinc finger protein 175 protein, from Human, contains 711 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 13 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Down-regulates the expression of several chemokine receptors, Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity


This is Metal-response element-binding transcription factor 2 protein, from Human, contains 593 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557), Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity), Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity), Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity), In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity), Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity)


This is Dystrobrevin alpha protein, from Human, contains 743 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors


This is TNF receptor-associated factor 6 protein, from Human, contains 522 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:31620128, PubMed:11057907, PubMed:18347055, PubMed:19713527, PubMed:19465916), Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (PubMed:19675569), Leads to the activation of NF-kappa-B and JUN (PubMed:16378096, PubMed:17135271, PubMed:17703191), Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity), Represses c-Myb-mediated transactivation, in B-lymphocytes (PubMed:18093978, PubMed:18758450), Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:8837778, PubMed:19825828, PubMed:12140561), Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity), Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity), Participates also in the TCR signaling by ubiquitinating LAT (PubMed:25907557, PubMed:23514740)

Belongs to the TNF receptor-associated factor family, A subfamily


This is E3 ubiquitin-protein ligase RNF115 protein, from Human, contains 304 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes, Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4


This is Krueppel-like factor 12 protein, from Human, contains 402 amino acids, has 3 C2H2-type Zinc finger.

Confers strong transcriptional repression to the AP-2-alpha gene, Binds to a regulatory element (A32) in the AP-2-alpha gene promoter


This is E3 ubiquitin-protein ligase ARIH1 protein, from Human, contains 557 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686), Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346), The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346), E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346), Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349), According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349), According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119), Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916), In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology (PubMed:29689197)

Belongs to the RBR family, Ariadne subfamily


This is E3 ubiquitin-protein ligase RNF114 protein, from Human, contains 228 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885), In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287), Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885), May promote the ubiquitination of TRAF6 as well (PubMed:28708287), Acts also as a negative regulator of T-cell activation (PubMed:25165885), Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885), Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206), This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence, May play a role in spermatogenesis


This is E3 ubiquitin-protein ligase TRIM17 protein, from Human, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:22023800, PubMed:19358823, PubMed:27562068), Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation (PubMed:22023800), Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies, Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (PubMed:27562068), Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death, In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities, Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity), Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (PubMed:19358823)


This is Zinc finger and SCAN domain-containing protein 21 protein, from Human, contains 473 amino acids, has 7 C2H2-type Zinc finger.

Strong transcriptional activator (By similarity), Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity)


This is Ubiquitin carboxyl-terminal hydrolase 16 protein, from Human, contains 823 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355), Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355), In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes, Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355), Prefers nucleosomal substrates (PubMed:17914355), Does not deubiquitinate histone H2B (PubMed:17914355), Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764)

Belongs to the peptidase C19 family, USP16 subfamily


This is Krueppel-like factor 2 protein, from Human, contains 355 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504), Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758)


This is Photoreceptor-specific nuclear receptor protein, from Human, contains 410 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor of retinal photoreceptor cells, Transcriptional factor that is an activator of rod development and repressor of cone development, Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit, Enhances rhodopsin expression, Represses M- and S-cone opsin expression


This is Junctional adhesion molecule A protein, from Human, contains 299 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa

Belongs to the immunoglobulin superfamily


This is Neuroplastin protein, from Human, contains 398 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK, May also regulate neurite outgrowth by activating the FGFR1 signaling pathway, May play a role in synaptic plasticity (By similarity), Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470), Promotes localization of XKR8 at the cell membrane (PubMed:27503893)


This is Ubiquitin carboxyl-terminal hydrolase 3 protein, from Human, contains 520 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B, Required for proper progression through S phase and subsequent mitotic entry, May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites, Associates with the chromatin

Belongs to the peptidase C19 family, USP3 subfamily


This is DNA (cytosine-5)-methyltransferase 3A protein, from Human, contains 912 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443), DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443), It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443), May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity), Plays a role in paternal and maternal imprinting (By similarity), Required for methylation of most imprinted loci in germ cells (By similarity), Acts as a transcriptional corepressor for ZBTB18 (By similarity), Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity), Can actively repress transcription through the recruitment of HDAC activity (By similarity), Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity)

Belongs to the class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family


This is NF-kappa-B essential modulator protein, from Human, contains 419 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

(Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B


This is Diacylglycerol kinase beta protein, from Human, contains 804 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Does not associate with membranes but has a diacylglycerol kinase activity

Belongs to the eukaryotic diacylglycerol kinase family


This is Inducible T-cell costimulator protein, from Human, contains 199 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells, Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens, Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10, Prevents the apoptosis of pre-activated T-cells, Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)


This is E3 SUMO-protein ligase PIAS3 protein, from Human, contains 628 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway, Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth, Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184), Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032), Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376)


This is Zinc fingers and homeoboxes protein 2 protein, from Human, contains 837 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor (PubMed:12741956), Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956), May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity), In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity)


This is Estrogen receptor protein, from Channel catfish, contains 617 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Tyrosine-protein kinase receptor TYRO3 protein, from Zebrafish, contains 874 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be involved in cell adhesion processes, particularly in the central nervous system

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Autoimmune regulator protein, from Mouse, contains 552 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable), Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-, ATTGGTTA-3' combined with a 5'-TTATTA-3' box, Binds to nucleosomes (By similarity), Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2', Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression, Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (By similarity), Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program (PubMed:19015306), Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression (PubMed:21300913), Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes (PubMed:19923453), In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection (PubMed:26070482), In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells, Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (PubMed:23993652)


This is Neuronal growth regulator 1 protein, from Rat, contains 348 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May be involved in cell-adhesion, May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity)

Belongs to the immunoglobulin superfamily, IgLON family


This is Oxysterols receptor LXR-alpha protein, from Mouse, contains 445 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281), Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES, LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides, Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8, Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity), Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:28846071, PubMed:25806685), Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685), Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Krueppel-like factor 5 protein, from Mouse, contains 446 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to GC box promoter elements, Activates the transcription of these genes


This is Semaphorin-4F protein, from Mouse, contains 777 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Probable cell surface receptor that regulates oligodendroglial precursor cell migration (PubMed:21945643), Might also regulate differentiation of oligodendroglial precursor cells (By similarity), Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)