This is Vacuolar protein sorting-associated protein 11 homolog protein, from Caenorhabditis elegans, contains 980 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301), Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity), The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity), Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423, PubMed:25273556), The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity), Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25273556), Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity), Possibly has a role in clearance of apoptotic cells during programmed cell death (PubMed:18425118, PubMed:18923146)


This is Transcriptional regulator prz1 protein, from Fission yeast, contains 681 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Involved in the regulation of calcium ion homeostasis, Binds to the calcineurin-dependent response element, Transcriptionally regulates pmc1

Belongs to the EGR C2H2-type zinc-finger protein family


This is Zinc finger protein 415 protein, from Human, contains 603 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 11 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Involved in transcriptional regulation, Transcriptional activity differed among the various isoforms, All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53


This is Gag-Pro polyprotein protein, from HTLV-3, contains 584 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The aspartyl protease mediates proteolytic cleavages of Gag, Gag-Pro and Gag-Pro-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell, Hydrolyzes host EIF4GI in order to shut off the capped cellular mRNA translation, The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response (By similarity)


This is Ubiquitin C-terminal hydrolase 15 protein, from Rice, contains 975 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin, Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (Probable), Involved in the regulation of grain size (PubMed:30796160), Acts as positive regulator of grain width and size by influencing cell proliferation (PubMed:30796160), Functions partially antagonistically with GW2 in the regulation of grain width (PubMed:30796160), Possesses deubiquitinating enzyme activity in vitro (PubMed:30796160)


This is B-box zinc finger protein 20 protein, from Mouse-ear cress, contains 242 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Acts as positive regulator of seedling photomorphogenesis, Plays a negative role in brassinosteroid responses


This is E3 ubiquitin-protein ligase RNF126 protein, from Bovine, contains 313 amino acids, has 1 C4-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins, Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates, Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome, Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome, May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor, May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination, By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation, May monoubiquitinate AICDA


This is E3 ubiquitin-protein ligase RNF168 protein, from Bovine, contains 573 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage, Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination, Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates, This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1, Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites, Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region, Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)


This is Chaperone protein dnaJ A6 protein, from Rice, contains 416 amino acids, has 1 CR-type Zinc finger.

CR-type

Involved in disease resistance, Acts as negative regulator of innate immunity to the rice blast fungus (Magnaporthe oryzae), Acts as negative regulator of the pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) response through the inhibition of reactive oxygen species (ROS) accumulation and expression of defense-related genes, May function via the ubiquitin-proteasome degradation pathway


This is E3 ubiquitin-protein ligase NEURL1B protein, from Mouse, contains 546 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands


This is Sine oculis-binding protein homolog protein, from Mouse, contains 864 amino acids, has 2 FCS-type Zinc finger.

FCS-type

FCS-type

Implicated in development of the cochlea


This is Tripartite motif-containing protein 5 protein, from Rhesus macaque, contains 497 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses, Blocks viral replication early in the life cycle, after viral entry but before reverse transcription, In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice, Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3), Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell, Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm), Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057), Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057)


This is MAM domain-containing glycosylphosphatidylinositol anchor protein 1 protein, from Mouse, contains 956 amino acids, has 6 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Required for radial migration of cortical neurons in the superficial layer of the neocortex, Plays a role in the formation or maintenance of inhibitory synapses, May function by inhibiting the activity of NLGN2


CCHC-type

CCHC-type


This is Nuclear receptor subfamily 4 group A member 1 protein, from Bovine, contains 598 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration, Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3', May inhibit NF-kappa-B transactivation of IL2, Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity), Plays a role in the vascular response to injury (By similarity)

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is Hepatocyte growth factor-regulated tyrosine kinase substrate protein, from Bovine, contains 777 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Involved in intracellular signal transduction mediated by cytokines and growth factors, When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF, Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin, May concentrate ubiquitinated receptors within clathrin-coated regions, Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex), The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes, May contribute to the efficient recruitment of SMADs to the activin receptor complex, Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity)


This is F-box only protein 5 protein, from Zebrafish, contains 384 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

During embryonic development, regulates the integrity of the genome and therefore the cell cycle progression by preventing rereplication through an APC-Cdh1-dependent mechanism


This is Ubiquitin carboxyl-terminal hydrolase 16 protein, from Western clawed frog, contains 864 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator, Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis, Regulates Hox gene expression via histone H2A deubiquitination, Prefers nucleosomal substrates, Does not deubiquitinate histone H2B

Belongs to the peptidase C19 family, USP16 subfamily


This is E3 ubiquitin-protein ligase RNF13 protein, from Bovine, contains 380 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that regulates cell proliferation, Involved in apoptosis regulation, Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA, Also involved in protein trafficking and localization


This is E3 ubiquitin-protein ligase MARCHF8 protein, from Bovine, contains 289 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity, Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins, Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation, Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway, Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination, Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity


This is Fez family zinc finger protein 1 protein, from Mouse, contains 475 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor, Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN), Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation, Expression is required in OSN to cell-autonomously regulate OSN axon projections, Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons, May be required for correct rostral migration of the interneuron progenitors

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Polyadenylation and cleavage factor homolog 4 protein, from Mouse-ear cress, contains 808 amino acids, has 1 C2H2-type Zinc finger.

Promotes flowering by suppressing FLC-mediated inhibition of flowering through the regulation of FCA pre-mRNA alternative processing (PubMed:18298670), Regulates mRNA maturation including alternative polyadenylation, splicing or transcription initiation of stress-associated genes (PubMed:21364912)


This is E3 ubiquitin-protein ligase APD1 protein, from Mouse-ear cress, contains 441 amino acids, has 1 RING-type Zinc finger.

RING-type

Involved in pollen mitosis II (PMII) regulation during male gametogenesis


This is DNA replication licensing factor MCM4 protein, from Mouse-ear cress, contains 847 amino acids, has 1 C4-type Zinc finger.

Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells


This is Putative E3 ubiquitin-protein ligase RING1b protein, from Mouse-ear cress, contains 460 amino acids, has 1 RING-type Zinc finger.

RING-type

As part of the PRC1-like complex, repress class I KNOX gene expression, PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility


This is Nexilin protein, from Human, contains 675 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Involved in regulating cell migration through association with the actin cytoskeleton, Has an essential role in the maintenance of Z line and sarcomere integrity


This is Iron-sensing transcriptional repressor protein, from Fission yeast, contains 564 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional repressor that binds the consensus promoter sequence 5'-[AT]GATAA-3' during iron-replete conditions to down-regulate transcription of target genes (PubMed:11956219, PubMed:25733668), Represses the expression of the iron transporter fio1 in response to high iron concentrations (PubMed:11956219, PubMed:25733668), Also represses the expression of str1, str2 and str3 (PubMed:12888492, PubMed:29549126), Represses the expression of shu1 in presence of iron (PubMed:25733668)


This is Transcription factor gaf1 protein, from Fission yeast, contains 855 amino acids, has 1 GATA-type Zinc finger.

GATA-type


This is Probable E3 ubiquitin-protein ligase dma1 protein, from Fission yeast, contains 267 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised, Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation, The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB

Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body


This is Histone acetyltransferase mst2 protein, from Fission yeast, contains 407 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation, Negatively regulates telomere silencing, Telomere silencing is increased due to histone hypoacetylation and/or an increase in the ratio of methylated histones to acetylated histones, Telomeric histone acetylation contributes to normal meiotic progression


This is Transcription factor elt-2 protein, from Caenorhabditis elegans, contains 433 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:7782329, PubMed:15733671, PubMed:18003741, PubMed:18024960, PubMed:18448117, PubMed:26700680, PubMed:26016853, PubMed:26963674), Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1, vit-2 and lev-11, and itself (PubMed:9659934, PubMed:10518545, PubMed:15733671, PubMed:18448117, PubMed:19111532, PubMed:26700680, PubMed:26963674), Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527), Regulates intestinal gene expression in response to hypoxia to promote longevity (PubMed:25284791), Modulation of longevity may, in part, be the result of regulation of expression of daf-16 isoforms d and f in the intestine (PubMed:24834345), Regulates tissue specific gene expression at basal levels and in response to bacterial infection in the intestine to control innate immunity (PubMed:16968778, PubMed:21168435, PubMed:25340560, PubMed:26016853), Plays a role in the induction of metal-responsive genes, activating gene expression from zinc-activated promoters and iron-dependent promoters and enhancers (PubMed:18024960, PubMed:22194696, PubMed:25552416), May regulate the expression of genes that control sensitivity to oxidative stress, in a mab-3-dependent manner, and osmotic stress, in conjunction with the GATA region-binding transcription factor elt-3 (PubMed:17901115, PubMed:20498281, PubMed:20126308), May play a role in sphingolipid signaling by regulating the expression of the sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735), May act with the Notch signaling pathway to promote endodermal gene expression (PubMed:18003741), Has a protective role in response to infection by Gram-negative bacteria such as S,enterica, E,coli, P,aeruginosa and B,pseudomallei, Gram-positive bacterium E,faecalis and fungal pathogen C,neoformans (PubMed:16968778, PubMed:17183709, PubMed:21168435, PubMed:23980181, PubMed:30265660), An association with the 26S proteasome regulatory subunit rpt-6, in part, controls gene expression in response to infection by P,aeruginosa (PubMed:30265660), Regulates gene expression during the recovery phase following a bacterial infection (PubMed:25340560, PubMed:30265660), May act with p38-activated transcription factors to control p38 gene induction in response to bacterial infection (PubMed:22967128, PubMed:26016853), Controls lysosome formation in the intestine by controlling lysosomal gene expression (PubMed:26828939)


This is tRNA:m(4)X modification enzyme TRM13 protein, from Rice, contains 250 amino acids, has 1 CHHC U11-48K-type Zinc finger.

CHHC U11-48K-type

tRNA methylase that catalyzes 2'-O-methyladenosine (Am) nucleoside formation on tRNA(Gly)(GCC) in vitro, May 2'-O-methylate cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His) (PubMed:28369540), Involved in salt stress tolerance (PubMed:28369540)

Belongs to the methyltransferase TRM13 family


This is E3 ubiquitin-protein ligase DIS1 protein, from Rice, contains 301 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 SIAH-type; degenerate Zinc finger.

RING-type; degenerate

SIAH-type; degenerate

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (Probable), Plays a negative role in drought stress tolerance through transcriptional and post-translational regulation of diverse stress-related genes, Interacts with the serine/threonine-protein kinase NEK6 and promotes its degradation via the 26S proteasome-dependent pathway (PubMed:21719639)

Belongs to the SINA (Seven in absentia) family


This is Transcriptional regulator MET32 protein, from Baker's yeast, contains 191 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Auxiliary transcriptional regulator of sulfur amino acid metabolism, Involved in the transcriptional activation of MET28


This is Pre-mRNA-splicing factor CWC2 protein, from Baker's yeast, contains 339 amino acids, has 1 C3H1-type Zinc finger.

Involved in the first step of pre-mRNA splicing, Required for cell growth and cell cycle control, Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex, May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA, Associates predominantly with U6 snRNAs in assembled active spliceosomes, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle, Binds also to U1, U4, U5 and U6 snRNAs and to pre-mRNAs, in vitro, Is not required for the Prp2-mediated remodeling of the activated spliceosome


This is Anaphase-promoting complex subunit 11 protein, from Baker's yeast, contains 165 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome, In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition, In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication, APC11 is required to recruit the ubiquitin-conjugating enzyme E2 to the APC/C


This is Transposon Ty3-G Gag polyprotein protein, from Baker's yeast, contains 290 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Nucleocapsid protein p9 (NC) forms the nucleocore that coats the retro-elements dimeric RNA, Binds these RNAs through its zinc fingers (By similarity), Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription


This is Branchpoint-bridging protein protein, from Baker's yeast, contains 476 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing, 2 commitment complexes, CC1 and CC2, have been defined, CC1 is a basal complex dependent only on the 5'-splice site, CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5'-splice site region, This protein is involved in CC2 formation where it binds to the snRNP U1-associated protein PRP40, bridging the U1 snRNP-associated 5'-splice site and the MSL5-associated branch point 3' intron splice site, Involved in nuclear retention of pre-mRNA


This is E3 SUMO-protein ligase SIZ2 protein, from Baker's yeast, contains 726 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

May act as an E3 ligase mediating SUMO/Smt3 attachment to septins, May be involved in chromosome maintenance


This is NuA3 HAT complex component NTO1 protein, from Baker's yeast, contains 748 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3, Recruitment of NuA3 to nucleosomes requires methylated histone H3, In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation


This is tRNA:m(4)X modification enzyme TRM13 protein, from Baker's yeast, contains 476 amino acids, has 1 CHHC U11-48K-type Zinc finger.

CHHC U11-48K-type

tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His)


This is Protein AIR2 protein, from Baker's yeast, contains 344 amino acids, has 3 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

Component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information, Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met, Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome, AIR2 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1


This is E3 ubiquitin-protein ligase RMD5 protein, from Baker's yeast, contains 421 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

E3 ubiquitin-protein ligase component of the GID complex (PubMed:12686616, PubMed:18508925), Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:9737955, PubMed:18508925), Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:9737955, PubMed:12686616, PubMed:18508925, PubMed:28126757)


This is Tyrosine-protein kinase Mer protein, from Human, contains 999 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6, Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis), Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules, Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1, MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697), Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis, Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Splicing factor 3A subunit 3 protein, from Human, contains 501 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:8022796, PubMed:10882114, PubMed:11533230), Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277)


This is Tripartite motif-containing protein 26 protein, from Human, contains 539 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

(Microbial infection) Promotes herpes simplex virus type 2/HHV-2 infection in vaginal epithelial cells by decreasing the nuclear localization of IRF3, the primary mediator of type I interferon activation


This is TNF receptor-associated factor 2 protein, from Human, contains 501 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:22212761), Required for normal antibody isotype switching from IgM to IgG, Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1, Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases, Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain, Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR, In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE

Belongs to the TNF receptor-associated factor family, A subfamily


This is E3 ubiquitin-protein ligase TRIM32 protein, from Human, contains 653 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

(Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269), Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269)


This is Probable E3 ubiquitin-protein ligase makorin-3 protein, from Human, contains 507 amino acids, has 3 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins


This is Zinc finger and BTB domain-containing protein 17 protein, from Human, contains 803 amino acids, has 13 C2H2-type Zinc finger.

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression, Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment, Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription, Required for early embryonic development during gastrulation, Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946)


This is TNF receptor-associated factor 3 protein, from Human, contains 568 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556), In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081), Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines, Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768), Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development, Required for normal antibody isotype switching from IgM to IgG, Plays a role T-cell dependent immune responses, Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B, Promotes ubiquitination and proteasomal degradation of MAP3K14


This is Krueppel-like factor 10 protein, from Human, contains 480 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3', Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity, Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver, Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity), May play a role in the cell cycle regulation

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Oxysterols receptor LXR-alpha protein, from Human, contains 447 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920), Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity), LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity), Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530), Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity), Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity), Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles, Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Calcium-binding and coiled-coil domain-containing protein 2 protein, from Human, contains 446 amino acids, has 1 UBZ1-type Zinc finger.

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation, Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324), Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791), Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791), May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994)


This is E3 ubiquitin-protein ligase CBL-B protein, from Human, contains 982 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome, Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways, In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production, Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation, In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy, In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation, Slightly promotes SRC ubiquitination, May be involved in EGFR ubiquitination and internalization, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3, In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity)


This is Semaphorin-3B protein, from Human, contains 749 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons


This is Transcription intermediary factor 1-beta protein, from Human, contains 835 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger, has 1 PHD-type Zinc finger.

RING-type

B box-type 1; atypical

B box-type

PHD-type

(Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection, This inhibition is mediated through interaction with herpes virus 8 protein LANA1


This is Semaphorin-3F protein, from Human, contains 785 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May play a role in cell motility and cell adhesion


This is Steroidogenic factor 1 protein, from Human, contains 461 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator, Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692), Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B, Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes, 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692), The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity, Binds phosphatidylcholine (By similarity), Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3, Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is Signaling lymphocytic activation molecule protein, from Human, contains 335 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for Measles virus; also including isoform 4


This is Metastasis-associated protein MTA1 protein, from Human, contains 715 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses


This is Nuclear body protein SP140 protein, from Human, contains 867 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577), May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577), May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382)


This is Krueppel-like factor 1 protein, from Human, contains 362 amino acids, has 3 C2H2-type Zinc finger.

Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis, Is a dual regulator of fetal-to-adult globin switching, Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene, Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes, This dual activity ensures that, in most adults, fetal hemoglobin levels are low, Able to activate CD44 and AQP1 promoters, When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation


This is Zinc finger protein 177 protein, from Human, contains 481 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 7 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 3; atypical

May be involved in transcriptional regulation


This is Zinc finger protein 211 protein, from Human, contains 564 amino acids, has 12 C2H2-type Zinc finger.


This is Butyrophilin subfamily 1 member A1 protein, from Human, contains 526 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

May function in the secretion of milk-fat droplets, May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity), Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity)

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is DNA-binding protein Ikaros protein, from Human, contains 519 amino acids, has 6 C2H2-type Zinc finger.

Transcription regulator of hematopoietic cell differentiation (PubMed:17934067), Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594), Plays a role in the development of lymphocytes, B- and T-cells, Binds and activates the enhancer (delta-A element) of the CD3-delta gene, Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation, Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes, Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes, Increases normal apoptosis in adult erythroid cells, Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity), Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Limbic system-associated membrane protein protein, from Human, contains 338 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Mediates selective neuronal growth and axon targeting, Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system, Essential for normal growth of the hippocampal mossy fiber projection (By similarity)

Belongs to the immunoglobulin superfamily, IgLON family


This is Mucosal addressin cell adhesion molecule 1 protein, from Human, contains 382 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria, It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes, Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding


This is Interleukin-18 receptor 1 protein, from Human, contains 541 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532), Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850), Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity)

Belongs to the interleukin-1 receptor family


This is Baculoviral IAP repeat-containing protein 3 protein, from Human, contains 604 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis, Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling, The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10, Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs), Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner, Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8


This is Baculoviral IAP repeat-containing protein 2 protein, from Human, contains 618 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis, Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling, The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1, Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation, Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs), Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner, Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8, Can stimulate the transcriptional activity of E2F1, Plays a role in the modulation of the cell cycle


This is Sequestosome-1 protein, from Human, contains 440 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Autophagy receptor required for selective macroautophagy (aggrephagy) (PubMed:34471133, PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177, PubMed:33509017), Functions as a bridge between polyubiquitinated cargo and autophagosomes (PubMed:34471133), Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177), Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures), Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092), Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566), May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1, May play a role in titin/TTN downstream signaling in muscle cells, May regulate signaling cascades through ubiquitination, Adapter that mediates the interaction between TRAF6 and CYLD (By similarity), May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels, Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102), Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741), Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215), Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860)


This is Diacylglycerol kinase zeta protein, from Human, contains 928 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Belongs to the eukaryotic diacylglycerol kinase family


This is Four and a half LIM domains protein 1 protein, from Human, contains 323 amino acids, has 1 C4-type Zinc finger.

May have an involvement in muscle development or hypertrophy


This is Four and a half LIM domains protein 3 protein, from Human, contains 280 amino acids, has 1 C4-type Zinc finger.

Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1


This is 43 kDa receptor-associated protein of the synapse protein, from Human, contains 412 amino acids, has 1 RING-type Zinc finger.

RING-type

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction, It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin


This is CD166 antigen protein, from Human, contains 583 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Inhibits activities of membrane-bound isoforms by competing for the same interaction partners, Inhibits cell attachment via homotypic interactions, Promotes endothelial cell migration, Inhibits endothelial cell tube formation


This is Krueppel-like factor 9 protein, from Human, contains 244 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to GC box promoter elements, Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box, Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835)


This is Krueppel-like factor 5 protein, from Human, contains 457 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to GC box promoter elements, Activates the transcription of these genes


This is General transcription factor IIH subunit 2 protein, from Human, contains 395 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription, The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter


This is General transcription factor IIH subunit 3 protein, from Human, contains 308 amino acids, has 1 C4-type Zinc finger.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription


This is Carcinoembryonic antigen-related cell adhesion molecule 7 protein, from Human, contains 265 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, CEA family


This is Vascular endothelial zinc finger 1 protein, from Human, contains 521 amino acids, has 6 C2H2-type Zinc finger.

Possible transcription factor, Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3


This is Tripartite motif-containing protein 29 protein, from Human, contains 588 amino acids, has 1 B box-type Zinc finger.

B box-type

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract, Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation, In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited, Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation


This is Tripartite motif-containing protein 14 protein, from Human, contains 442 amino acids, has 1 B box-type Zinc finger.

B box-type

Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352), Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373), Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593), Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression (PubMed:32404352), Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity)


This is MORC family CW-type zinc finger protein 3 protein, from Human, contains 939 amino acids, has 1 CW-type Zinc finger.

CW-type

(Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233)


This is ARF GTPase-activating protein GIT2 protein, from Human, contains 759 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for ADP ribosylation factor family members, including ARF1


This is Four and a half LIM domains protein 2 protein, from Human, contains 279 amino acids, has 1 C4-type Zinc finger.

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation, Negatively regulates the transcriptional repressor E4F1 and may function in cell growth, Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation, Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008)


This is E3 ubiquitin/ISG15 ligase TRIM25 protein, from Human, contains 630 amino acids, has 1 RING-type Zinc finger.

RING-type

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599), Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:30193849, PubMed:33849980, PubMed:29357390, PubMed:31710640), Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712), Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849), Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755), Mediates estrogen action in various target organs (PubMed:22452784), Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784), Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity), Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses, Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28202764, PubMed:28060952), Mediates also the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236)


This is Hypermethylated in cancer 1 protein protein, from Human, contains 733 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional repressor (PubMed:12052894, PubMed:15231840), Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840), May act as a tumor suppressor (PubMed:20154726), Involved in development of head, face, limbs and ventral body wall (By similarity), Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335), The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755), In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755), Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116), Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893), Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726)

Belongs to the krueppel C2H2-type zinc-finger protein family, Hic subfamily


This is Hepatocyte nuclear factor 4-gamma protein, from Human, contains 408 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor, Has a lower transcription activation potential than HNF4-alpha

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Semaphorin-3A protein, from Human, contains 771 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Involved in the development of the olfactory system and in neuronal control of puberty, Induces the collapse and paralysis of neuronal growth cones, Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism, Binds to the complex neuropilin-1/plexin-1


This is Zinc finger protein 266 protein, from Human, contains 549 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 12 C2H2-type Zinc finger.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

May be involved in transcriptional regulation


This is Zinc finger protein 345 protein, from Human, contains 488 amino acids, has 15 C2H2-type Zinc finger.


This is Zinc finger protein 268 protein, from Human, contains 947 amino acids, has 24 C2H2-type Zinc finger.

Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex


This is Zinc finger protein 460 protein, from Human, contains 562 amino acids, has 11 C2H2-type Zinc finger.


This is Next to BRCA1 gene 1 protein protein, from Human, contains 966 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:33577621, PubMed:24692539), Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133), Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352), In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity), In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity), Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity)


This is Interleukin-11 receptor subunit alpha protein, from Human, contains 422 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177), The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177)

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Ras GTPase-activating protein 3 protein, from Human, contains 834 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Inhibitory regulator of the Ras-cyclic AMP pathway, Binds inositol tetrakisphosphate (IP4) with high affinity, Might be a specific IP4 receptor


This is Intercellular adhesion molecule 4 protein, from Human, contains 271 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins

Belongs to the immunoglobulin superfamily, ICAM family


This is Metal regulatory transcription factor 1 protein, from Human, contains 753 amino acids, has 6 C2H2-type Zinc finger.

Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932), Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932), Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity)


This is Zinc finger protein 169 protein, from Human, contains 603 amino acids, has 11 C2H2-type Zinc finger, has 1 C2H2-type 11; degenerate Zinc finger, has 1 C2H2-type 13; degenerate Zinc finger.

C2H2-type 11; degenerate

C2H2-type 13; degenerate

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Killer cell immunoglobulin-like receptor 3DS1 protein, from Human, contains 382 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for MHC class I molecules, Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production

Belongs to the immunoglobulin superfamily


This is Killer cell immunoglobulin-like receptor 2DS5 protein, from Human, contains 304 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles, Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925), Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691), Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972)


This is Killer cell immunoglobulin-like receptor 2DS1 protein, from Human, contains 304 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for some HLA-C alleles such as w6, Does not inhibit the activity of NK cells


This is Opioid-binding protein/cell adhesion molecule protein, from Human, contains 345 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Binds opioids in the presence of acidic lipids; probably involved in cell contact


This is Nuclear receptor subfamily 1 group I member 3 protein, from Human, contains 352 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes, Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element


This is Nuclear receptor subfamily 1 group D member 2 protein, from Human, contains 579 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK, Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1, Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN, Regulates hepatic lipid metabolism via the repression of APOC3, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), In addition to its activity as a repressor, can also act as a transcriptional activator, Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity), Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity), Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity), May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity)


This is Cytotoxic and regulatory T-cell molecule protein, from Mouse, contains 393 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (PubMed:15811952, PubMed:18329370, PubMed:19752223, PubMed:24687959), Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952), Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (PubMed:18329370), Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (PubMed:19752223), Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (PubMed:18329370), By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (PubMed:19752223), Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959), Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959)


This is E3 ubiquitin-protein ligase RNF133 protein, from Mouse, contains 382 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Has E3 ubiquitin-protein ligase activity


This is Ataxin-7-like protein 3 protein, from Human, contains 347 amino acids, has 1 SGF11-type Zinc finger.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination, Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879), The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription, Required for nuclear receptor-mediated transactivation, Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972), Regulates H2B monoubiquitination (H2Bub1) levels, Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583)


This is Hepatic and glial cell adhesion molecule protein, from Human, contains 416 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Involved in regulating cell motility and cell-matrix interactions, May inhibit cell growth through suppression of cell proliferation


This is Receptor-transporting protein 5 protein, from Human, contains 572 amino acids, has 1 3CxxC-type Zinc finger.


This is Polycomb protein SUZ12 protein, from Human, contains 739 amino acids, has 1 C2H2-type Zinc finger.

Polycomb group (PcG) protein, Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557), The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464), Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557)

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 protein, from Human, contains 740 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface, Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration


This is Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 protein, from Human, contains 778 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6)


This is Zinc finger protein OZF protein, from Human, contains 292 amino acids, has 10 C2H2-type Zinc finger.


This is Advanced glycosylation end product-specific receptor protein, from Human, contains 404 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed:27572515, PubMed:28515150, PubMed:34743181), Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed:21565706), These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses, Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B (PubMed:21829704), Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (PubMed:19386136), Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity), Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed:19906677), ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space, Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (PubMed:27572515), Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (PubMed:34743181), Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (PubMed:24081950, PubMed:28515150)


This is Programmed cell death protein 1 protein, from Human, contains 288 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311), The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311), The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552)


This is Serine/threonine-protein kinase D1 protein, from Human, contains 912 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839), Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301), Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS), Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway, In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane, May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface, Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989), Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion, In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061), In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells, May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression, Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway, Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134), Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics, The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839), In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration, During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790), In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957), Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity), May play a role in inflammatory response by mediating activation of NF-kappa-B, May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852), Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306), Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S,enterica infection (By similarity)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is Nectin-1 protein, from Human, contains 517 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV


This is Ras GTPase-activating protein 2 protein, from Human, contains 850 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Inhibitory regulator of the Ras-cyclic AMP pathway, Binds inositol tetrakisphosphate (IP4)


This is Zinc finger MYND domain-containing protein 11 protein, from Human, contains 602 amino acids, has 1 PHD-type Zinc finger, has 1 MYND-type Zinc finger.

PHD-type

MYND-type

(Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction


This is Nuclear receptor subfamily 6 group A member 1 protein, from Human, contains 480 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Binds to a response element containing the sequence 5'-TCAAGGTCA-3', May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity)

Belongs to the nuclear hormone receptor family, NR6 subfamily


This is Splicing factor 3A subunit 2 protein, from Human, contains 464 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230), Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29361316, PubMed:29360106, PubMed:30315277), Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106)


This is Transcription elongation factor A protein 2 protein, from Human, contains 299 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites, The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes, Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus


This is Splicing factor 1 protein, from Human, contains 639 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Necessary for the ATP-dependent first step of spliceosome assembly, Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA, May act as transcription repressor


This is Zinc finger HIT domain-containing protein 3 protein, from Human, contains 155 amino acids, has 1 HIT-type Zinc finger.

HIT-type


This is Activating signal cointegrator 1 protein, from Human, contains 581 amino acids, has 1 C4-type Zinc finger.

Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (PubMed:10454579, PubMed:25219498), May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498), Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498), Also involved in androgen receptor transactivation (By similarity), Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 (PubMed:12077347), Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347), May play a role in the development of neuromuscular junction (PubMed:26924529), May play a role in late myogenic differentiation (By similarity), Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773)


This is U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 protein, from Human, contains 482 amino acids, has 2 C3H1-type Zinc finger.

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns, Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing, Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes, For U2-type introns, it is selectively and specifically required for the second step of splicing


This is Zinc finger protein 174 protein, from Human, contains 407 amino acids, has 3 C2H2-type Zinc finger.


This is CD226 antigen protein, from Human, contains 336 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704), Cell surface receptor for NECTIN2, Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG, Competes with PVRIG for NECTIN2-binding (PubMed:26755705)


This is Zinc finger protein with KRAB and SCAN domains 8 protein, from Human, contains 578 amino acids, has 9 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein ZIC 1 protein, from Human, contains 447 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Acts as a transcriptional activator, Involved in neurogenesis, Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum, Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN), Plays a role in the regulation of MF axon pathway choice, Promotes MF migration towards ipsilaterally-located cerebellar territories, May have a role in shear flow mechanotransduction in osteocytes, Retains nuclear GLI1 and GLI3 in the cytoplasm, Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity)

Belongs to the GLI C2H2-type zinc-finger protein family


This is Zinc finger and BTB domain-containing protein 6 protein, from Human, contains 424 amino acids, has 4 C2H2-type Zinc finger.


This is Zinc finger protein 141 protein, from Human, contains 474 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 10 C2H2-type Zinc finger.

C2H2-type 1; atypical

May be involved in transcriptional regulation as a repressor, Plays a role in limb development


This is Zinc finger protein 124 protein, from Human, contains 351 amino acids, has 8 C2H2-type Zinc finger.


This is Insulin-like growth factor-binding protein 7 protein, from Human, contains 282 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds IGF-I and IGF-II with a relatively low affinity, Stimulates prostacyclin (PGI2) production, Stimulates cell adhesion


This is NT-3 growth factor receptor protein, from Human, contains 839 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in nervous system and probably heart development, Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is Programmed cell death protein 2 protein, from Human, contains 344 amino acids, has 1 MYND-type; atypical Zinc finger.

MYND-type; atypical

May be a DNA-binding protein with a regulatory function, May play an important role in cell death and/or in regulation of cell proliferation


This is Zinc finger protein 74 protein, from Human, contains 644 amino acids, has 12 C2H2-type Zinc finger.


This is Zinc finger protein 239 protein, from Human, contains 458 amino acids, has 9 C2H2-type Zinc finger.


This is BDNF/NT-3 growth factors receptor protein, from Human, contains 822 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity), Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731), Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731), Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions, May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia


This is Serine/arginine-rich splicing factor 7 protein, from Human, contains 238 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for pre-mRNA splicing, Can also modulate alternative splicing in vitro, Represses the splicing of MAPT/Tau exon 10, May function as export adapter involved in mRNA nuclear export such as of histone H2A, Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity, RNA-binding is semi-sequence specific

Belongs to the splicing factor SR family


This is Myelin-oligodendrocyte glycoprotein protein, from Human, contains 247 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

(Microbial infection) Acts as a receptor for rubella virus

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Zinc finger and SCAN domain-containing protein 26 protein, from Human, contains 478 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 7 C2H2-type Zinc finger.

C2H2-type 1; degenerate


This is Endoplasmic reticulum junction formation protein lunapark-1 protein, from Caenorhabditis elegans, contains 342 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity), May be involved in central nervous system development, Has a presynaptic role in neurotransmission, Likely to operate in synaptogenesis by regulating vesicular transport or localization, Required for correct localization of rab-3 and snb-1


This is LON peptidase N-terminal domain and RING finger protein 1 protein, from Human, contains 773 amino acids, has 2 RING-type Zinc finger.

RING-type

RING-type


This is Early growth response factor homolog 1 protein, from Caenorhabditis elegans, contains 461 amino acids, has 3 C2H2-type Zinc finger.

Sequence-specific DNA-binding transcription factor (By similarity), Plays a role in oocyte development, acting cell-autonomously in the somatic gonad (PubMed:20736289), Involved in negative regulation of oocyte MAPK activation and inhibits oocyte maturation and ovulation (PubMed:20736289)

Belongs to the EGR C2H2-type zinc-finger protein family