This is E3 ubiquitin-protein ligase BRE1A protein, from Human, contains 975 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively), It thereby plays a central role inb histone code and gene regulation, The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory, Required for transcriptional activation of Hox genes, Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator, Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation


This is Ubiquitin thioesterase OTU1 protein, from Human, contains 348 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore, Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel, Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains, Also able to hydrolyze 'Lys-11'-linked ubiquitin chains, Cleaves both polyubiquitin and di-ubiquitin, May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes, May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622)


This is Transcription initiation factor TFIID subunit 3 protein, from Human, contains 929 amino acids, has 1 PHD-type Zinc finger.

PHD-type

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473), TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473), The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473), The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473), TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473), Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666), The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666)


This is Muscleblind-like protein 2 protein, from Human, contains 373 amino acids, has 4 C3H1-type Zinc finger.

Mediates pre-mRNA alternative splicing regulation, Acts either as activator or repressor of splicing on specific pre-mRNA targets, Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle, Antagonizes the alternative splicing activity pattern of CELF proteins, RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3, Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs, Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques, May play a role in myotonic dystrophy pathophysiology (DM)


This is ORC ubiquitin ligase 1 protein, from Human, contains 726 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578), Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578)


This is ADP-ribosylation factor GTPase-activating protein AGD3 protein, from Mouse-ear cress, contains 827 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF), Involved in the spatial control of provascular differentiation, Required for the formation of the normal pattern of continuous secondary veins, Involved in auxin signaling but not in polar auxin transport or in auxin responses, Required for PIN1 internalization in roots


This is Histone acetyltransferase KAT8 protein, from Rat, contains 458 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Histone acetyltransferase which may be involved in transcriptional activation, May influence the function of ATM, As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac, As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues, That activity is less specific than the one of the MSL complex, Can also acetylate TP53/p53 at 'Lys-120'


This is E3 ubiquitin-protein ligase MARCHF7 protein, from Rat, contains 692 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity), May be involved in T-cell proliferation by regulating LIF secretion (By similarity), May play a role in lysosome homeostasis (By similarity)


This is E3 ubiquitin-protein ligase RNF10 protein, from Rat, contains 802 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling, Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome, Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation, The action of RNF10 in iRQC is counteracted by USP10 (By similarity), May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (PubMed:18941509), Acts as a regulator of Schwann cell differentiation and myelination (PubMed:18941509)


This is E3 ubiquitin-protein ligase MARCHF3 protein, from Rat, contains 253 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is E3 ubiquitin-protein ligase RNF146 protein, from Rat, contains 352 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex, Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2, Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation, Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48', May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location, Neuroprotective protein (By similarity), Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity), Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity), Does not affect PARP1 activation, Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity), Promotes cell survival after gamma-irradiation, Facilitates DNA repair (By similarity)


This is E3 ubiquitin-protein ligase RNF167 protein, from Rat, contains 349 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway, Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1, Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex, Also involved in protein trafficking and localization, Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2, Does not catalyze ubiquitination of GluA1/GRIA1, Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3, Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B, Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18, Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N


This is Protein Mdm4 protein, from Rat, contains 490 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Inhibits degradation of MDM2, Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity)


This is E3 ubiquitin-protein ligase MGRN1 protein, from Rat, contains 533 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, Mediates TSG101 monoubiquitination at multiple sites, Plays a role in the regulation of endosome-to-lysosome trafficking, Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production, Does not inhibit ADRB2-signaling, Does not promote MC1R ubiquitination, Acts also as a negative regulator of hedgehog signaling (By similarity)


This is Serine/threonine-protein kinase D2 protein, from Rat, contains 875 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion, May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression, In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-718 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B, In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77, Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation, During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens, In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway, During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors, In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane, Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis, In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN, Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is Protein odd-skipped-related 1 protein, from Zebrafish, contains 264 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional repressor (By similarity), Regulates mesoderm versus endoderm differentiation during gastrulation to regulate kidney versus vascular cell fate, Acts upstream of pax2a in kidney development and functions in glomerular maturation, after podocyte specification

Belongs to the Odd C2H2-type zinc-finger protein family


This is DNA replication licensing factor mcm4-A protein, from African clawed frog, contains 858 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity


This is TATA box-binding protein-associated factor RNA polymerase I subunit B protein, from Mouse-ear cress, contains 666 amino acids, has 1 RRN7-type Zinc finger.

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription, Binds rDNA promoters and plays a role in Pol I recruitment (By similarity), Required for the development of the one-cell zygote and endosperm in embryos (PubMed:15634699), Required for micropylar pollen tube guidance, but has no effect on ovule development and gametophytic cell fate specification (PubMed:18055609), May regulate the transcription of secreted cysteine-rich peptide (CRP) genes in the embryo sac (PubMed:26462908)


This is Zinc finger CCCH domain-containing protein 46 protein, from Rice, contains 390 amino acids, has 1 C3H1-type Zinc finger.

Transcriptional activator that binds double-stranded DNA and the single-stranded RNA polymers poly(rA), poly(rU) and poly(rG), but not poly(rC), Mediates optimal plant architecture through brassinosteroid (BR) signaling, May act as a negative regulator in sterol homeostasis (PubMed:18953406), Acts as negative regulator of BR signaling, Binds to the specific DNA sequence 5'-CTCGC-3' of BZR1 promoter and negatively regulates BZR1, Acts as an antagonistic transcription factor of BZR1 to attenuate the BR signaling pathway and regulate leaf bending, Represses the expression of ILI1, and activates that of IBH1 to balance the regulation activity of BZR1 (PubMed:22570626)


This is E3 ubiquitin-protein ligase IPI1 protein, from Rice, contains 455 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Functions as an E3 ligase that promotes polyubiquitination of SPL14/IPA1 for subsequent proteasomal degradation (PubMed:28298520), Regulates plant architecture by modulating SPL14/IPA1 abundance (PubMed:28298520), Promotes the degradation of SPL14/IPA1 in panicles, while it stabilizes SPL14/IPA1 in shoot apices (PubMed:28298520), Ubiquitinates the SPL14/IPA1-mediated complex with 'Lys-48'-linked polyubiquitin in panicles and 'Lys-63'-linked polyubiquitin chains in the shoot apex (PubMed:28298520)


This is B-cell lymphoma 6 protein homolog protein, from Chicken, contains 708 amino acids, has 6 C2H2-type Zinc finger.

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions, Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes, Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors, In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response, In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells, Also required for the establishment and maintenance of immunological memory for both T- and B-cells, Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2, In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners, Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation (By similarity)


This is CD276 antigen protein, from Human, contains 534 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like V-type

Ig-like C2-type

May participate in the regulation of T-cell-mediated immune response, May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells, May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces, Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy, Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses, Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Low affinity immunoglobulin gamma Fc region receptor II protein, from Guinea pig, contains 341 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Binds to the Fc region of immunoglobulins gamma, Low affinity receptor


This is E3 ubiquitin-protein ligase Mdm2 protein, from Golden hamster, contains 466 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome, Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Also acts as a ubiquitin ligase E3 toward itself and ARRB1, Permits the nuclear export of p53/TP53, Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein, Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation, Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53, Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways, Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus, Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation, Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells, Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity), Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity), Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity)


This is DNA-binding protein SMUBP-2 protein, from Golden hamster, contains 989 amino acids, has 1 AN1-type Zinc finger.

5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (By similarity), Specific to 5'-phosphorylated single-stranded guanine-rich sequences (By similarity), May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (By similarity), May play a role in regulation of transcription (By similarity), Interacts with tRNA-Tyr (By similarity)

Belongs to the DNA2/NAM7 helicase family


This is Intercellular adhesion molecule 5 protein, from Mouse, contains 917 amino acids, has 9 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

Belongs to the immunoglobulin superfamily, ICAM family


This is COUP transcription factor 1 protein, from Mouse, contains 422 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription, Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif, Represses transcriptional activity of LHCG (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is PR domain zinc finger protein 1 protein, from Mouse, contains 856 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484), Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484), Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity), Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity), Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484), Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (PubMed:32741026)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Bile acid receptor protein, from Mouse, contains 488 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Activates transcription of IBAP and SDC1

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Oxysterols receptor LXR-beta protein, from Mouse, contains 446 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281), Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281), Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281), Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281, PubMed:24206663, PubMed:28846071), Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:28846071, PubMed:25806685), Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685), Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663), Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity)


This is Nuclear receptor subfamily 1 group D member 2 protein, from Mouse, contains 576 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK, Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1, Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN, Regulates hepatic lipid metabolism via the repression of APOC3, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), In addition to its activity as a repressor, can also act as a transcriptional activator, Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle, Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (PubMed:29355503), Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (PubMed:29723273), May play a role in the circadian control of neutrophilic inflammation in the lung (PubMed:29533925)


This is Tumor necrosis factor alpha-induced protein 3 protein, from Mouse, contains 775 amino acids, has 7 A20-type Zinc finger.

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity, Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways, In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3, In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3, Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains, This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B, Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin, Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation, Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation, Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2, Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation, Targets TRAF2 for lysosomal degradation, In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains, Inhibitor of programmed cell death, Has a role in the function of the lymphoid system, Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages


This is Krueppel-like factor 4 protein, from Mouse, contains 483 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor; can act both as activator and as repressor, Binds the 5'-CACCC-3' core sequence (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216), Binds to the promoter region of its own gene and can activate its own transcription (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216), Regulates the expression of key transcription factors during embryonic development (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216), Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216), Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface, Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development, Contributes to the down-regulation of p53/TP53 transcription (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is TNF receptor-associated factor 3 protein, from Mouse, contains 567 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:17015635), In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:19898473, PubMed:23871208, PubMed:26305951, PubMed:23150880), Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines (PubMed:16306937), Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance, Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development (PubMed:17723217), Required for normal antibody isotype switching from IgM to IgG (PubMed:19228877), Plays a role T-cell dependent immune responses (PubMed:8934568), Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B, Promotes ubiquitination and proteasomal degradation of MAP3K14

Belongs to the TNF receptor-associated factor family, A subfamily


This is Tyrosine-protein kinase Mer protein, from Mouse, contains 994 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6, Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis), Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules, Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1, MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment, Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis, Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Zinc finger and BTB domain-containing protein 17 protein, from Mouse, contains 794 amino acids, has 13 C2H2-type Zinc finger.

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression, Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription, Required for early embryonic development during gastrulation, Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment, Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 (By similarity)


This is Krueppel-like factor 2 protein, from Mouse, contains 354 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription, Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (By similarity)


This is Rho guanine nucleotide exchange factor 2 protein, from Mouse, contains 985 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Activates Rho-GTPases by promoting the exchange of GDP for GTP, May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer, Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, May stimulate instead the cortical activity of Rac, Inactive toward CDC42, TC10, or Ras-GTPases, Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens, Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase, Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2, Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity), Involved in neuronal progenitor cell division and differentiation (PubMed:28453519), Involved in the migration of precerebellar neurons (PubMed:28453519)


This is Protein PML protein, from Mouse, contains 885 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms, Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions, Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation), Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum, Regulates RB1 phosphorylation and activity, Acts as both a negative regulator of PPARGC1A acetylation and a potent activator of PPAR signaling and fatty acid oxidation, Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization, Regulates PER2 nuclear localization and circadian function, Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway, Required for normal development of the brain cortex during embryogenesis, Plays a role in granulopoiesis or monopoiesis of myeloid progenitor cells, May play a role regulating stem and progenitor cell fate in tissues as diverse as blood, brain and breast, Shows antiviral activity towards lymphocytic choriomeningitis virus (LCMV) and the vesicular stomatitis virus (VSV)


This is Krueppel-like factor 3 protein, from Mouse, contains 344 amino acids, has 3 C2H2-type Zinc finger.

Binds to the CACCC box of erythroid cell-expressed genes, May play a role in hematopoiesis


This is E3 ubiquitin-protein ligase XIAP protein, from Mouse, contains 496 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (By similarity), Acts as a direct caspase inhibitor (By similarity), Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (By similarity), Inhibits apoptosis in intestinal crypt cells, its activity is mitigated via its interaction with SEPTIN4 isoform ARTS (PubMed:30389919), Inactivates CASP9 by keeping it in a monomeric, inactive state (By similarity), Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:18761086, PubMed:19473982), Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:29452636), 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (By similarity), Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (By similarity), Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (By similarity), Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (By similarity), Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (By similarity), Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (By similarity), Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (By similarity), Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (By similarity), Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (By similarity), Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (By similarity), Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (By similarity), Positive regulator of dermal wound repair, potentially via its interaction with SEPTIN4 (PubMed:23788729)


This is Guanine nucleotide exchange factor VAV2 protein, from Mouse, contains 868 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases, Plays an important role in angiogenesis, Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly


This is MHC class I-like protein MILL1 protein, from Rat, contains 404 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type


This is Muscle, skeletal receptor tyrosine-protein kinase protein, from Mouse, contains 868 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle, Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May positively regulate Rho family GTPases through FNTA, Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is E3 ubiquitin-protein ligase DTX1 protein, from Mouse, contains 627 amino acids, has 1 RING-type Zinc finger.

RING-type

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context, Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1, Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation, Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1, Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity


This is WW domain-binding protein 4 protein, from Mouse, contains 376 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the spliceosome, May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex


This is Kinase suppressor of Ras 1 protein, from Mouse, contains 873 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (PubMed:10409742, PubMed:12932319, PubMed:21102438, PubMed:21441104), Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (By similarity), Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (PubMed:21102438), Its kinase activity is unsure (PubMed:21441104), Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (PubMed:21441104)

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family


This is Interleukin-18 receptor 1 protein, from Mouse, contains 537 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B, Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity), Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (PubMed:26099046)

Belongs to the interleukin-1 receptor family


This is Zinc finger protein ubi-d4 protein, from Mouse, contains 391 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Plays an active role in transcriptional regulation by binding modified histones H3 and H4, Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity), Might also have a role in the development and maturation of lymphoid cells (PubMed:7961935), Involved in the regulation of non-canonical NF-kappa-B pathway (By similarity)


This is Transcriptional repressor CTCF protein, from Mouse, contains 736 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 11; atypical Zinc finger.

C2H2-type 11; atypical

Chromatin binding factor that binds to DNA sequence specific sites, Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers, Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene, Also binds to the PLK and PIM1 promoters, Acts as a transcriptional activator of APP, Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression, Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription, Seems to act as tumor suppressor, Plays a critical role in the epigenetic regulation, Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus, On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2, Plays a critical role in gene silencing over considerable distances in the genome, Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones, Inversely, binding to target sites is prevented by CpG methylation, Plays an important role in chromatin remodeling, Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (By similarity), Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory, Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription, When bound to chromatin, it provides an anchor point for nucleosomes positioning, Seems to be essential for homologous X-chromosome pairing, May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation, May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation, Involved in sister chromatid cohesion, Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites, Regulates asynchronous replication of IGF2/H19, Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (By similarity)

Belongs to the CTCF zinc-finger protein family


This is Transcription factor GATA-6 protein, from Mouse, contains 589 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519), May regulate genes that protect epithelial cells from bacterial infection (By similarity), Involved in gene regulation specifically in the gastric epithelium (By similarity), Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343), Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343)


This is Brevican core protein protein, from Mouse, contains 883 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a role in the terminally differentiating and the adult nervous system during postnatal development, Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

Secreted, extracellular space, extracellular matrix

Belongs to the aggrecan/versican proteoglycan family


This is TNF receptor-associated factor 4 protein, from Mouse, contains 470 amino acids, has 1 RING-type Zinc finger, has 3 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

TRAF-type

Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis, Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation, Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation, Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair, In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (By similarity), Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors, Required for normal skeleton development, and for normal development of the respiratory tract, Required for activation of RPS6KB1 in response to TNF signaling, Modulates TRAF6 functions, Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (By similarity)

Belongs to the TNF receptor-associated factor family, B subfamily


This is Leukocyte immunoglobulin-like receptor subfamily B member 4B protein, from Mouse, contains 303 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is CD166 antigen protein, from Mouse, contains 583 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts, Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity), Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity), Mediates homotypic interactions with cells that express ALCAM (PubMed:24740813), Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction, Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:23169771), Required for normal organization of the lymph vessel network (PubMed:23169771), Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813), Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow (PubMed:25730656), Promotes in vitro osteoblast proliferation and differentiation (PubMed:25730656), Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity), Mediates outgrowth and pathfinding for retinal ganglion cell axons (PubMed:15345243)


This is E3 ubiquitin/ISG15 ligase TRIM25 protein, from Mouse, contains 634 amino acids, has 1 RING-type Zinc finger.

RING-type

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase, Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1, Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection, Mediates 'Lys-63'-linked polyubiquitination of IFIH1, Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway, Mediates estrogen action in various target organs, Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (By similarity), Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (PubMed:29125140), Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses, Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA, Mediates also the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (By similarity)


This is Steroid hormone receptor ERR2 protein, from Mouse, contains 433 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcriptional activity (PubMed:27601327, PubMed:23169531, PubMed:23508100, PubMed:26206133, PubMed:20534447, PubMed:18662995, PubMed:18957414, PubMed:27723719, PubMed:23019124), Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways (PubMed:18957414, PubMed:26206133, PubMed:20534447, PubMed:23040478, PubMed:23040477, PubMed:23019124, PubMed:23169531), Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells (PubMed:26206133), Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (PubMed:20534447), Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:18662995, PubMed:23508100, PubMed:18957414), Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity), During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase (PubMed:27723719), Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation (PubMed:23019124, PubMed:23169531, PubMed:18662995, PubMed:26206133), This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program (PubMed:23169531), Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (PubMed:9285590, PubMed:17765677)

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is RNA-binding protein EWS protein, from Mouse, contains 655 amino acids, has 1 RanBP2-type Zinc finger.

Might function as a transcriptional repressor


This is IgG receptor FcRn large subunit p51 protein, from Mouse, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn, Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7504013), IgG in the milk is bound at the apical surface of the intestinal epithelium, The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids, Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation, Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation, In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB

Belongs to the immunoglobulin superfamily


This is Insulin-like growth factor-binding protein 7 protein, from Mouse, contains 281 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production, Stimulates cell adhesion (By similarity)


This is Zinc finger protein 148 protein, from Mouse, contains 794 amino acids, has 4 C2H2-type Zinc finger.

Involved in transcriptional regulation, Represses the transcription of a number of genes including gastrin, stromelysin and enolase, Binds to the G-rich box in the enhancer region of these genes


This is Interleukin-1 receptor accessory protein protein, from Mouse, contains 570 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Required for Src phosphorylation by IL1B, Required for IL1B-potentiated NMDA-induced calcium influx in neurons acting in cooperation with IL1R1 isoform 2 to mediate Akt kinase activation


This is Leukocyte surface antigen CD47 protein, from Mouse, contains 303 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Adhesive protein that mediates cell-to-cell interactions (By similarity), Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (By similarity), Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:27742621, PubMed:20610415, PubMed:23591719), Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621), Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (PubMed:20610415), Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity), Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity), Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity), Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (PubMed:15917238), Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764), In response to THBS1, negatively modulates wound healing (PubMed:18156939), Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (PubMed:23591719), May play a role in membrane transport and/or integrin dependent signal transduction (By similarity), May prevent premature elimination of red blood cells (PubMed:10856220)


This is Lymphocyte activation gene 3 protein protein, from Mouse, contains 521 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response


This is Mucosal addressin cell adhesion molecule 1 protein, from Mouse, contains 405 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria, It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes, Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7, Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding


This is Fibroblast growth factor receptor 3 protein, from Mouse, contains 801 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis, Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development, Regulates both osteogenesis and postnatal bone mineralization by osteoblasts, Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation, Required for normal development of the inner ear, Phosphorylates PLCG1, CBL and FRS2, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Plays a role in the regulation of vitamin D metabolism, Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling, Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, STAT5A and STAT5B, Plays a role in postnatal lung development

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Myelin-oligodendrocyte glycoprotein protein, from Mouse, contains 246 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Minor component of the myelin sheath, May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication, Mediates homophilic cell-cell adhesion

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Protein CBFA2T1 protein, from Mouse, contains 577 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes, Can repress the expression of MMP7 in a ZBTB33-dependent manner, Can repress transactivation mediated by TCF12 (By similarity), Acts as a negative regulator of adipogenesis (PubMed:23527555)


This is Zinc finger protein 90 protein, from Mouse, contains 636 amino acids, has 13 C2H2-type Zinc finger.

Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes


This is Protein kinase C iota type protein, from Mouse, contains 595 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway, Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis, In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step, In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD, Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion, In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival, Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR, This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation, Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity, Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs), In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis (By similarity), Downstream of PI3K is required for insulin-stimulated glucose transport, Activates RAB4A and promotes its association with KIF3A which is required for the insulin-induced SLC2A4/GLUT4 translocation in adipocytes, Is essential in early embryogenesis and development of differentiating photoreceptors by playing a role in the establishment of epithelial and neuronal polarity, Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Serine/threonine-protein kinase D1 protein, from Mouse, contains 918 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:12407104, PubMed:14963034, PubMed:15192707, PubMed:20463010, PubMed:24161911, PubMed:28716882), Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation, Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS) (PubMed:11784866), Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway, In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane (PubMed:11239398), May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface, Under oxidative stress, is phosphorylated at Tyr-469 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1, Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion (PubMed:15192707), In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:19029091), In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells, May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression, Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway (PubMed:14963034, PubMed:20463010), Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:24161911), Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics, The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation, In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration, During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents, In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines, Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:28716882), May play a role in inflammatory response by mediating activation of NF-kappa-B, May be involved in pain transmission by directly modulating TRPV1 receptor, Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (By similarity), Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S,enterica infection (PubMed:27184844)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is Advanced glycosylation end product-specific receptor protein, from Mouse, contains 402 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Down-regulates receptor for advanced glycosylation end products (RAGE)-ligand induced signaling through various MAPK pathways including ERK1/2, p38 and SAPK/JNK, Significantly affects tumor cell properties through decreasing cell migration, invasion, adhesion and proliferation, and increasing cellular apoptosis, Exhibits drastic inhibition on tumorigenesis in vitro


This is Zinc finger protein RFP protein, from Mouse, contains 513 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:24144979), Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation (By similarity), Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (By similarity), Has a transcriptional repressor activity by cooperating with EPC1 (By similarity), Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events (By similarity), May function in male germ cell development (By similarity), Has DNA-binding activity and preferentially bound to double-stranded DNA (By similarity), Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis (PubMed:24144979), In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (By similarity), Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (By similarity), Alternatively, facilitates mitophagy via TBK1 activation (By similarity), Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (By similarity), During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (By similarity)


This is Semaphorin-4A protein, from Mouse, contains 760 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:20043131, PubMed:17318185), Regulates glutamatergic and GABAergic synapse development (PubMed:29981480), Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480), Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988), Promotes phosphorylation of TIMD2 (PubMed:12374982), Inhibits angiogenesis (PubMed:17318185), Promotes axon growth cone collapse (PubMed:20043131), Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131)


This is Semaphorin-4B protein, from Mouse, contains 823 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons


This is Semaphorin-3C protein, from Mouse, contains 751 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to plexin family members and plays an important role in the regulation of developmental processes, Required for normal cardiovascular development during embryogenesis, Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance


This is E3 ubiquitin-protein ligase TRIM21 protein, from Mouse, contains 470 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2, Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination, Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes, A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome, Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling, Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3, Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway, Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages, Plays a role in the regulation of the cell cycle progression, Enhances the decapping activity of DCP2, Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules, At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified, The common feature of these proteins is their ability to bind HY RNAs,2, Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma, Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy, Regulates also autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability, Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:17579016), Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI, During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation, When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity


This is Baculoviral IAP repeat-containing protein 2 protein, from Mouse, contains 612 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis, Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling, The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1, Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation, Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs), Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner, Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8, Can stimulate the transcriptional activity of E2F1, Plays a role in the modulation of the cell cycle


This is Transcription intermediary factor 1-beta protein, from Mouse, contains 834 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger, has 1 PHD-type Zinc finger.

RING-type

B box-type

B box-type

PHD-type

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs) (PubMed:20164836, PubMed:22110054, PubMed:25247314, PubMed:27658112), Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes, Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression, Recruitment of SETDB1 induces heterochromatinization, May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1, Also a corepressor for ERBB4, Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation, May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1, Important regulator of CDKN1A/p21(CIP1), Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger, Specifically sumoylates IRF7, thereby inhibiting its transactivation activity, Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6, Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors, Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells, Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:20164836), In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (PubMed:20164836), Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing, The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity), Acts as a corepressor for ZFP568 (PubMed:22110054, PubMed:27658112)


This is Zinc finger protein ZPR1 protein, from Mouse, contains 459 amino acids, has 2 C4-type Zinc finger.

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus, It is involved in the positive regulation of cell cycle progression (By similarity), Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies, Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons, Plays a role in the splicing of cellular pre-mRNAs, May be involved in H(2)O(2)-induced neuronal cell death


This is Zinc finger protein ZIC 2 protein, from Mouse, contains 530 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Acts as a transcriptional activator or repressor, Plays important roles in the early stage of organogenesis of the CNS, Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets, Its transcriptional activity is repressed by MDFIC, Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline, Drives the expression of EPHB1 on ipsilaterally projecting growth cones, Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3', Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos

Belongs to the GLI C2H2-type zinc-finger protein family


This is Zinc finger protein ZIC 3 protein, from Mouse, contains 466 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Acts as transcriptional activator, Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification, Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'


This is Metastasis-associated protein MTA1 protein, from Rat, contains 703 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (By similarity), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity), In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (By similarity), In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (By similarity), Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (By similarity), Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (), Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (By similarity), Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (By similarity), Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity), Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity), Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity), With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity)


This is Interleukin-1 receptor-like 1 protein, from Rat, contains 566 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Oxysterols receptor LXR-alpha protein, from Rat, contains 445 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity, Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES, LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides, Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8, Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity), Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity), Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity), Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Neurotrimin protein, from Rat, contains 344 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Belongs to the immunoglobulin superfamily, IgLON family


This is Bile acid receptor protein, from Rat, contains 469 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA), Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation, Also regulates lipid and glucose homeostasis and is involved innate immune response, The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands, It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity, In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs), Activates transcription of the repressor MAFG (involved in regulation of BA synthesis), Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine), Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine), In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression, The function also involves the coordinated induction of hepatic KLB/beta-klotho expression, Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA, Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly), Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance), Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element, Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase), Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes, Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3), Modulates glucose-stimulated insulin secretion and is involved in insulin resistance, Involved in intestinal innate immunity, Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier, Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells, Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2, Involved in the TLR9-mediated protective mechanism in intestinal inflammation, Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling


This is Oxysterols receptor LXR-beta protein, from Rat, contains 446 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity), Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4), Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8, Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity), Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity), Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles, Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity), Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity)


This is Zinc finger protein 148 protein, from Rat, contains 794 amino acids, has 4 C2H2-type Zinc finger.

Involved in transcriptional regulation, Represses the transcription of a number of genes including gastrin, stromelysin and enolase, Binds to the G-rich box in the enhancer region of these genes

Belongs to the krueppel C2H2-type zinc-finger protein family