This is TNF receptor-associated factor 6 protein, from Mouse, contains 530 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:15322147, PubMed:17633018), Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity), Leads to the activation of NF-kappa-B and JUN, Seems to also play a role in dendritic cells (DCs) maturation and/or activation (PubMed:14499111), Represses c-Myb-mediated transactivation, in B-lymphocytes (By similarity), Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:10421844, PubMed:10215628), Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (PubMed:10421844, PubMed:17092936), Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (PubMed:12881420), Participates also in the TCR signaling by ubiquitinating LAT (By similarity)


This is Semaphorin-3E protein, from Mouse, contains 775 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Plays an important role in signaling via the cell surface receptor PLXND1, Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections, Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix, Regulates angiogenesis, both during embryogenesis and after birth, Can down-regulate sprouting angiogenesis, Required for normal vascular patterning during embryogenesis, Plays an important role in ensuring the specificity of synapse formation


This is Zinc finger protein Gfi-1 protein, from Mouse, contains 423 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor essential for hematopoiesis, Functions in a cell-context and development-specific manner, Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes, Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development, Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:17197705), Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (PubMed:17197705), Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling, Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752), Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth, Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters, Required for the maintenance of inner ear hair cells (PubMed:12441305)


This is TRAF family member-associated NF-kappa-B activator protein, from Mouse, contains 448 amino acids, has 1 UBZ1-type Zinc finger.

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity, Acts as a regulator of TRAF function by maintaining them in a latent state, Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation, Negatively regulates NF-kappaB signaling and cell survival upon DNA damage, Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage, Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage, May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2, Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus


This is Hereditary hemochromatosis protein homolog protein, from Mouse, contains 359 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin


This is RNA-binding protein 10 protein, from Rat, contains 852 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type; atypical Zinc finger.

C2H2-type; atypical

Not known, Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (PubMed:8760884), May bind to specific miRNA hairpins (By similarity)


This is Coxsackievirus and adenovirus receptor protein, from Human, contains 365 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6


This is E3 ubiquitin-protein ligase RNF4 protein, from Human, contains 190 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556), Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951), Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317), Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589), Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770), Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556)


This is Tyrosine-protein phosphatase non-receptor type substrate 1 protein, from Human, contains 504 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Ig-like C1-type

Immunoglobulin-like cell surface receptor for CD47, Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane, Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity), Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin, Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation, CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells, Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity), Receptor for THBS1 (PubMed:24511121), Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity), In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121)


This is Butyrophilin subfamily 3 member A2 protein, from Human, contains 334 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Plays a role in T-cell responses in the adaptive immune response, Inhibits the release of IFNG from activated T-cells

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Zinc finger protein rst2 protein, from Fission yeast, contains 567 amino acids, has 2 C2H2-type Zinc finger.

Key transcription factor for sexual development, Activates the transcription of ste11, Binds to a stress response element-like (SRE) region in the ste11 promoter


This is ATP-dependent helicase rhp16 protein, from Fission yeast, contains 861 amino acids, has 1 RING-type Zinc finger.

RING-type

Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation

Belongs to the SNF2/RAD54 helicase family


This is Glucocorticoid receptor protein, from Cotton-top tamarin, contains 777 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Steroidogenic factor 1 protein, from Pig, contains 461 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator, Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues, Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B, Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes, 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1, The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity, Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3, Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is HLA class II histocompatibility antigen, DR beta 3 chain protein, from Human, contains 266 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M, tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic (PubMed:32341563), Presents immunogenic epitopes derived from C, tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:2788702), Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection (PubMed:16148104)


This is Proline-rich protein 3 protein, from Human, contains 188 amino acids, has 1 C3H1-type Zinc finger.


This is Glucocorticoid receptor protein, from Ma's night monkey, contains 777 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Macrophage colony-stimulating factor 1 receptor 1 protein, from Japanese pufferfish, contains 975 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, Plays an important role in innate immunity and in inflammatory processes, Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development, Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, Activates several signaling pathways in response to ligand binding (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Chicken, contains 156 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome, Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is Zinc finger protein Helios protein, from Mouse, contains 526 amino acids, has 6 C2H2-type Zinc finger.

Associates with Ikaros at centromeric heterochromatin

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Polymeric immunoglobulin receptor protein, from Bovine, contains 757 amino acids, has 1 Ig-like V-type 1; required for binding to polymeric IgA and IgM Immunoglobulin domain, has 4 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens, On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells


This is E3 ubiquitin-protein ligase Midline-1 protein, from Rat, contains 667 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination


This is Transcriptional regulator ATRX protein, from Tammar wallaby, contains 497 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Involved in transcriptional regulation and chromatin remodeling, Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci, Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures, May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3,3-containing nucleosomes, Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3,3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3,3-containing nucleosomes, Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5, May be involved in transcriptional regulation of telomeric repeat-containing RNA (TERRA), Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres, Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels, Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (By similarity)


This is Dystrobrevin beta protein, from Rat, contains 654 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids, May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation, May be required for proper maturation and function of a subset of inhibitory synapses

Belongs to the dystrophin family, Dystrobrevin subfamily


This is MAM domain-containing glycosylphosphatidylinositol anchor protein 1 protein, from Rat, contains 956 amino acids, has 6 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity), Plays a role in the formation or maintenance of inhibitory synapses, May function by inhibiting the activity of NLGN2


This is Zinc finger BED domain-containing protein 6 protein, from Human, contains 979 amino acids, has 2 BED-type Zinc finger.

BED-type

BED-type

Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity), Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity), Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity), Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity), Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity), Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816), Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity), Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity), May also play a role in embryonic beta cell differentiation (By similarity), May play a role in insulin sensitivity and glucose clearance (By similarity)


This is Pre-mRNA-splicing factor cwf2 protein, from Fission yeast, contains 388 amino acids, has 1 C3H1-type Zinc finger.

Involved in the first step of pre-mRNA splicing, Required for cell growth and cell cycle control, Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex, May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA, Associates predominantly with U6 snRNAs in assembled active spliceosomes, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity), Involved in pre-mRNA splicing


This is DNA-(apurinic or apyrimidinic site) endonuclease 2 protein, from Fission yeast, contains 523 amino acids, has 1 GRF-type Zinc finger.

GRF-type

DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA, Provides the majority of the AP-endonuclease (APE) activity, Repairs phleomycin D1-induced DNA damage, Plays a role in oxidative damage repair

Belongs to the DNA repair enzymes AP/ExoA family


This is E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 protein, from Fission yeast, contains 269 amino acids, has 1 RING-type Zinc finger.

RING-type

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains, Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression, Involved in stabilizing, restarting or resolving transiently stalled replication forks, Prevents accumulation of DNA damage during cell cycle progression (By similarity)


This is E3 ubiquitin-protein ligase MIR2 protein, from HHV-8, contains 256 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

Membrane-bound E3 ubiquitin ligase expressed at the immediate early stage of viral reactivation to mediate polyubiquitination of various host membrane proteins related to the immune response (PubMed:10799607, PubMed:10859362, PubMed:11413168, PubMed:24899205), Promotes ubiquitination and subsequent degradation of host MHC-I, CD86, DC-SIGN and DC-SIGNR, ICAM1 and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell (PubMed:11413168, PubMed:23460925), Binds target molecules through transmembrane interaction, E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein, The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed, Alters monocyte metabolism and proliferation by mediating rapid internalization of cellular growth factor-binding receptor tyrosine kinases from the surface leading to increased signaling (PubMed:21490960)


This is E3 ubiquitin-protein ligase MIR1 protein, from HHV-8, contains 333 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

Membrane-bound E3 ubiquitin ligase expressed during late stages of lytic replication to mediate polyubiquitination of various host membrane proteins related to the immune response (PubMed:24899205), Promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, DC-SIGN and DC-SIGNR, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes (PubMed:10859362, PubMed:11756476), Binds target molecules through transmembrane interaction, E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein, The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed, Induces ubiquitination not only on lysines, but also on cysteine residues


This is Fanconi-associated nuclease 1 homolog protein, from Caenorhabditis elegans, contains 865 amino acids, has 1 UBZ4-type Zinc finger.

Nuclease required for the repair of DNA interstrand cross-links (ICL), Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions


This is Protein kinase C-like 2 protein, from Caenorhabditis elegans, contains 682 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (PubMed:22593072), PKC also serves as the receptor for phorbol esters, a class of tumor promoters (Probable), Through phosphorylation of unc-18 in the AFD thermosensory neuron, plays a role in regulating temperature-dependent locomotion (PubMed:22593072)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Structure-specific endonuclease subunit SLX1 homolog protein, from Caenorhabditis elegans, contains 443 amino acids, has 1 SLX1-type Zinc finger.

Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination, Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential), Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures (PubMed:22927825), Required for proper crossover distribution through inhibition of crossover formation at the central region of chromosomes (PubMed:22927825, PubMed:23874210)


This is Nuclear hormone receptor family member nhr-69 protein, from Caenorhabditis elegans, contains 373 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor which, in cooperation with R-SMAD daf-8, modulates the Insulin/IGF-1-like signaling (IIS) pathway, perhaps by regulating expression of the potassium channel exp-2, which in turn modulates the secretion of insulin-like peptide daf-28

Belongs to the nuclear hormone receptor family


This is Protein lin-28 protein, from Caenorhabditis elegans, contains 227 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Heterochronic protein which controls the choice of stage specific cell fates (PubMed:9054503, PubMed:6494891, PubMed:2702689, PubMed:2628162, PubMed:1916265, PubMed:7671811, PubMed:8625405, PubMed:8756295, PubMed:8756296, PubMed:9477318, PubMed:9649524, PubMed:10706289, PubMed:12871707, PubMed:15073154, PubMed:16139228), Regulates the timing of the second larval stage events (L2 events) in the hypodermis (PubMed:2702689, PubMed:2628162), May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3 (PubMed:10706289, PubMed:12871707, PubMed:16139228), Through this regulatory role, controls the timing of the sexual maturation of the nervous system (PubMed:31264582), Also has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153), Plays a role in governing the developmental timing of male tail tip morphogenesis (PubMed:26811380, PubMed:30956008), Plays a role in controlling the seam cell number during larval stages (PubMed:21471153, PubMed:28602583), Plays a role in vulval development (PubMed:28602583)


This is Squamosa promoter-binding-like protein 3 protein, from Mouse-ear cress, contains 131 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3' of AP1 promoter, Binds specifically to the 5'-GTAC-3' core sequence, Promotes both vegetative phase change and flowering, Regulates phase-specific patterns of leaf epidermal differentiation and flowering time, but does not seem to affect leaf shape


This is E3 ubiquitin-protein ligase RMA2 protein, from Mouse-ear cress, contains 193 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of the auxin-binding protein ERABP1


This is Putative E3 ubiquitin-protein ligase SINAT1 protein, from Mouse-ear cress, contains 305 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:28351989, PubMed:32786047), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:28351989, PubMed:32786047), It probably triggers the ubiquitin-mediated degradation of different substrates (PubMed:28351989, PubMed:32786047), Mediates the proteasomal-dependent degradation of ATG6, a component of the autophagosome complex (PubMed:28351989), Requires TRAF1A/MUSE14 and TRAF1B/MUSE13 to target ATG6 for ubiquitination and subsequent regulation of autophagosome assembly (PubMed:28351989), Modulates directly the ubiquitination and proteasomal-dependent degradation of FREE1, a component of the ESCRT-I complex (PubMed:32786047, PubMed:32753431), Modulates directly the ubiquitination and proteasomal-dependent degradation of ELC/VPS23A, a component of the ESCRT-I complex (PubMed:32753431)

Belongs to the SINA (Seven in absentia) family


This is Zinc finger protein 8 protein, from Mouse-ear cress, contains 257 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin, Is not involved in the regulation of trichome branching, Is functionally equivalent to GIS2 (PubMed:17507408), Acts as negative regulator of abscisic acid (ABA) signaling during germination and early seedling development (PubMed:24808098)


This is Chaperone protein DnaJ protein, from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), contains 378 amino acids, has 1 CR-type Zinc finger.

CR-type

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion, Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex, GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle, Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding, Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins


This is Neuroplastin protein, from Mouse, contains 397 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK, May also regulate neurite outgrowth by activating the FGFR1 signaling pathway, May play a role in synaptic plasticity (By similarity), Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity, Promotes localization of XKR8 at the cell membrane (By similarity)


This is SH3 and cysteine-rich domain-containing protein protein, from Mouse, contains 403 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity (PubMed:27149520), Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163), Slows the rate of calcium-mediated inactivation of CACNA1C calcium channel activity (PubMed:29363593)


This is DNA replication licensing factor MCM2 protein, from Mouse, contains 904 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, Required for the entry in S phase and for cell division (PubMed:10567526), Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (By similarity)


This is TATA box-binding protein-associated factor RNA polymerase I subunit B protein, from Mouse, contains 586 amino acids, has 1 RRN7-type Zinc finger.

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription, Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3


This is Next to BRCA1 gene 1 protein protein, from Mouse, contains 988 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:31916398, PubMed:34374750), Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates, Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity), In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (PubMed:31916398), In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (PubMed:31916398), Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (PubMed:34374750)


This is Histone-lysine N-methyltransferase Smyd1 protein, from Mouse, contains 490 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Methylates histone H3 at 'Lys-4' (H3K4me), Acts as a transcriptional repressor, Essential for cardiomyocyte differentiation and cardiac morphogenesis

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Four and a half LIM domains protein 1 protein, from Mouse, contains 280 amino acids, has 1 C4-type Zinc finger.

May have an involvement in muscle development or hypertrophy, Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems


This is Zinc finger protein SNAI2 protein, from Mouse, contains 269 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; atypical Zinc finger.

C2H2-type 5; atypical

Transcriptional repressor that modulates both activator-dependent and basal transcription, Involved in the generation and migration of neural crest cells, Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells, Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells, In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription, Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes, Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes, Represses E-Cadherin/CDH1 transcription via E-box elements, Involved in osteoblast maturation, Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts, Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts, Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity)

Belongs to the snail C2H2-type zinc-finger protein family


This is Leukocyte immunoglobulin-like receptor subfamily B member 3 protein, from Mouse, contains 841 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May act as receptor for class I MHC antigens, Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor, Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)


This is Transcription factor GATA-5 protein, from Mouse, contains 404 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcription factor required during cardiovascular development (By similarity), Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (PubMed:9119112), Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity)


This is Cytoplasmic tyrosine-protein kinase BMX protein, from Mouse, contains 651 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis, Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins, Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation, Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility, Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis, Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation, Also involved in interleukin-6 (IL6) induced differentiation, Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts, May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1, May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Neuroplastin protein, from Rat, contains 393 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (PubMed:10759566, PubMed:16925595), May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (PubMed:10759566, PubMed:16925595), May play a role in synaptic plasticity (PubMed:10759566, PubMed:16925595), Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity, Promotes localization of XKR8 at the cell membrane (By similarity)


This is Tyrosine-protein phosphatase non-receptor type substrate 1 protein, from Rat, contains 509 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Ig-like C1-type

Immunoglobulin-like cell surface receptor for CD47, Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane, Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, May play a key role in intracellular signaling during synaptogenesis and in synaptic function, Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin, Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation, CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells, Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity), Receptor for THBS1 (PubMed:24511121), Interaction with THBS1 stimulates phosphorylation of SIRPA (PubMed:24511121), In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121)


This is Coxsackievirus and adenovirus receptor homolog protein, from Mouse, contains 365 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity, Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes, The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair, Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases, It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair


This is Tyrosine-protein phosphatase non-receptor type substrate 1 protein, from Mouse, contains 513 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Ig-like C1-type

Immunoglobulin-like cell surface receptor for CD47 (PubMed:18045614), Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane, Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, May play a key role in intracellular signaling during synaptogenesis and in synaptic function, Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin, Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation, CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity), Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (PubMed:30726215), Receptor for THBS1 (By similarity), Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity), In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (By similarity)


This is Leukocyte surface antigen CD47 protein, from Rat, contains 303 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Adhesive protein that mediates cell-to-cell interactions, Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins, Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation, Plays a role in modulating pulmonary endothelin EDN1 signaling (By similarity), Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity), Plays an important role in memory formation and synaptic plasticity in the hippocampus (PubMed:9592107), Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells, Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity), Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity), Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (By similarity), In response to THBS1, negatively modulates wound healing, Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity), May play a role in membrane transport and/or integrin dependent signal transduction (By similarity), May prevent premature elimination of red blood cells (By similarity)


This is Sodium channel subunit beta-1 protein, from Mouse, contains 218 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle, Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation, Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A

Belongs to the sodium channel auxiliary subunit SCN1B (TC 8,A,17) family


This is Zinc finger X-linked protein ZXDA protein, from Human, contains 799 amino acids, has 10 C2H2-type Zinc finger.

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes


This is E3 ubiquitin-protein ligase XIAP protein, from Human, contains 497 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (PubMed:11447297, PubMed:12121969, PubMed:9230442, PubMed:11257230, PubMed:11257231, PubMed:12620238, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:17560374), Acts as a direct caspase inhibitor (PubMed:11257230, PubMed:11257231, PubMed:12620238), Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (PubMed:11257230, PubMed:11257231, PubMed:16352606, PubMed:16916640), Inactivates CASP9 by keeping it in a monomeric, inactive state (PubMed:12620238), Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:22607974, PubMed:30026309, PubMed:29452636, PubMed:17560374), Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:19667203, PubMed:22607974, PubMed:30026309, PubMed:29452636), 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (PubMed:22607974, PubMed:29452636), Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (PubMed:17560374), Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (PubMed:20154138), Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (PubMed:17967870, PubMed:22103349), Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (PubMed:14685266), Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (PubMed:21145488), Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (PubMed:29020630), Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (PubMed:22095281), Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (PubMed:22095281), Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (PubMed:22304967), Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (PubMed:22304967)


This is FYVE, RhoGEF and PH domain-containing protein 1 protein, from Human, contains 961 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Plays a role in regulating the actin cytoskeleton and cell shape


This is RNA-binding protein 10 protein, from Human, contains 930 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type; atypical Zinc finger.

C2H2-type; atypical

May be involved in post-transcriptional processing, most probably in mRNA splicing, Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity), May bind to specific miRNA hairpins (PubMed:28431233)


This is Endonuclease 8 1 protein, from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), contains 268 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, DNA glycosylase that recognizes and removes damaged pyrimidines, Excises Tg:A (thymine glycol, prefers 5R isomers), Tg:G, 5,6-dihydrouracil:G base pairs and urea:A, also excises oxidized purine derivatives guanidinohydantoin:C and spiroiminodihydantoin:C, Poorly cleaves dsDNA with uracil substitutions, thus also acting as a weak uracil-DNA glycosylase, Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair, Activity on 7,8-dihydro-8-oxoguanine (8-oxoG) is debated; a report shows weak activity (PubMed:18457574), whereas another shows none (PubMed:20031487), Has AP (apurinic/apyrimidinic) activity and introduces nicks in dsDNA strand, inefficiently cleaves ssDNA with AP sites and uracil, Probably cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates, Cleaves ssDNA containing an AP site, Complements an E,coli fpg mutY but not nei nth double mutant (PubMed:18457574)


This is Endonuclease 8 2 protein, from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), contains 255 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity), Complements an E,coli nei nth double mutant (PubMed:20031487)


This is Formamidopyrimidine-DNA glycosylase 1 protein, from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), contains 289 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG) when paired with C, G or T, as well as methyl-faPy (formanidopyrimidine residues) in poly(dG-dC) and spiroiminodihydantoin:C base pairs, Unlike its E,coli ortholog has no activity on 8-oxoG:A, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates, Cleaves ssDNA containing an AP site, Complements the H(2)O(2) sensitivity of an M,smegmatis fpg disruption mutant; upon expression in M,smegmatis excises 8-oxoG from dsDNA


This is UvrABC system protein A protein, from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), contains 972 amino acids, has 1 C4-type; atypical Zinc finger, has 1 C4-type Zinc finger.

C4-type; atypical

The UvrABC repair system catalyzes the recognition and processing of DNA lesions, UvrA is an ATPase and a DNA-binding protein, A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities, When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate, Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange

Belongs to the ABC transporter superfamily, UvrA family


This is Progesterone receptor protein, from Mouse, contains 926 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator of several progesteron-dependent promoters in a variety of cell types, Involved in activation of SRC-dependent MAPK signaling on hormone stimulation


This is pH-response transcription factor pacC/RIM101 protein, from Aspergillus nidulans, contains 678 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH, At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes, Specifically recognizes and binds the consensus sequence 5'-GCCARG-3', Required for virulence in invasive pulmonary aspergillosis (IPA)


This is Intercellular adhesion molecule 1 protein, from Rat, contains 545 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity)

Belongs to the immunoglobulin superfamily, ICAM family


This is Receptor-type tyrosine-protein kinase FLT3 protein, from Mouse, contains 1000 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells, Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR, Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1, Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B, Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B, Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways


This is Transcription initiation factor IIB protein, from Human, contains 316 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II), Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682), Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312), Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352), Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171), Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841), Modulates transcription start site selection (PubMed:10318856), Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194)


This is Macrophage colony-stimulating factor 1 receptor protein, from Rat, contains 978 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes, Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development, Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy, Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion, Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity), Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL, Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD, Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway, Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1, Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2, Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B, Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1, Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor (By similarity), In the central nervous system, may play a role in the development of microglia macrophages (By similarity)


This is Interleukin-6 receptor subunit beta protein, from Mouse, contains 917 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Signal-transducing molecule (PubMed:1602143), The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission, Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:1602143, PubMed:10661409), That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409), In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (PubMed:9202125), Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (PubMed:25731159), Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649), Has a role in embryonic development (PubMed:10661409), Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352), Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188), Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504), Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596)

Belongs to the type I cytokine receptor family, Type 2 subfamily


This is T-lymphocyte activation antigen CD80 protein, from Mouse, contains 306 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Involved in the costimulatory signal essential for T lymphocytes activation, T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor


This is Pregnancy-specific beta-1-glycoprotein 9 protein, from Human, contains 426 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1 (PubMed:27389696), The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells (PubMed:27389696), Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset (PubMed:27389696), Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells (PubMed:27389696), May reduce the expression of several pro-inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6 (PubMed:27389696)

Belongs to the immunoglobulin superfamily, CEA family


This is Pregnancy-specific beta-1-glycoprotein 4 protein, from Human, contains 419 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Pregnancy-specific beta-1-glycoprotein 6 protein, from Human, contains 435 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Transcriptional repressor protein YY1 protein, from Mouse, contains 414 amino acids, has 4 C2H2-type Zinc finger.

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements

Belongs to the YY transcription factor family


This is Transcription factor STP1 protein, from Baker's yeast, contains 519 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels, Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases AGP1, BAP2, BAP3 and GNP1, Binding to promoters is facilitated by DAL81, Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response, Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes, May be involved in pre-tRNA splicing


This is Sodium channel subunit beta-1 protein, from Rat, contains 218 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle (PubMed:1375395, PubMed:8282123, PubMed:8021275, PubMed:15178439, PubMed:28012039), Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation (PubMed:1375395, PubMed:8282123, PubMed:8021275, PubMed:15178439, PubMed:28012039), Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A (PubMed:1375395, PubMed:8282123, PubMed:8021275, PubMed:15178439, PubMed:28012039)


This is Cyclic AMP-dependent transcription factor ATF-2 protein, from Rat, contains 487 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response, Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'), In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death, In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death, The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF), Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro, In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM, Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (By similarity)

Belongs to the bZIP family, ATF subfamily


This is E3 ubiquitin-protein ligase Mdm2 protein, from Human, contains 491 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome, Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Also acts as a ubiquitin ligase E3 toward itself and ARRB1, Permits the nuclear export of p53/TP53, Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein, Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation, Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53, Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways, Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus, Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911), Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity), Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity), Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903), Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903)


This is Tyrosine-protein kinase receptor UFO protein, from Mouse, contains 888 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation, Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL, Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11, Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2, Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase, GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses, Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Splicing factor U2AF 35 kDa subunit protein, from Human, contains 240 amino acids, has 2 C3H1-type Zinc finger.

Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection, Recruits U2 snRNP to the branch point, Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron

Belongs to the splicing factor SR family


This is Insulinoma-associated protein 1 protein, from Human, contains 510 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 4 C2H2-type Zinc finger.

C2H2-type 1; atypical

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development, Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters, Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner, Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway, Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases, Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism, Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412), Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex, Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system, Promotes cell cycle signaling arrest and inhibition of cellular proliferation


This is CD83 antigen protein, from Human, contains 205 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation


This is Broad-complex core protein isoforms 1/2/3/4/5 protein, from Fruit fly, contains 727 amino acids, has 2 C2H2-type Zinc finger.

Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis


This is Interleukin-1 receptor-like 1 protein, from Human, contains 556 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Belongs to the interleukin-1 receptor family


This is Methionine aminopeptidase 1 protein, from Baker's yeast, contains 387 amino acids, has 1 C6H2-type Zinc finger.

Cotranslationally removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val), Plays the major role in N-terminal methionine removal, Less efficient when the second residue is Val

Belongs to the peptidase M24A family, Methionine aminopeptidase type 1 subfamily


This is Transcription factor Sp1 protein, from Rat, contains 786 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli, Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses, Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation), Binds also the PDGFR-alpha G-box promoter, May have a role in modulating the cellular response to DNA damage, Implicated in chromatin remodeling, Plays an essential role in the regulation of FE65 gene expression, Positively regulates the transcription of the core clock component BMAL1 (By similarity), Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter (PubMed:19081374), Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is RNA-binding protein EWS protein, from Human, contains 656 amino acids, has 1 RanBP2-type Zinc finger.

Might normally function as a transcriptional repressor, EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process, They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex, They may also contribute to an aberrant activation of the fusion protein target genes


This is Zinc finger protein basonuclin-1 protein, from Human, contains 994 amino acids, has 6 C2H2-type Zinc finger.

Transcriptional activator (By similarity), It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748), Required for the maintenance of spermatogenesis (By similarity), It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909), May also play a role in the early development of embryos (By similarity)


This is Peroxisomal biogenesis factor 2 protein, from Yeast, contains 461 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 or PEX20 receptors from peroxisomes to the cytosol, thereby promoting PEX5 and PEX20 recycling (PubMed:23344950), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 and PEX20 through the peroxisomal membrane (By similarity), PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity), PEX2 ubiquitinates PEX5 or PEX20 during their passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 and/or PEX20 at 'Cys-6' and 'Cys-8', respectively, a modification that acts as a signal for PEX5 or PEX20 extraction into the cytosol (By similarity)


This is T-lymphocyte surface antigen Ly-9 protein, from Mouse, contains 654 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922), May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction, Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A, Promotes recruitment of RORC to the IL-17 promoter (By similarity), May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response, May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells (PubMed:23914190), May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (PubMed:23225888), Can promote natural killer (NK) cell activation (PubMed:19648922)


This is Inactive tyrosine-protein kinase transmembrane receptor ROR1 protein, from Human, contains 937 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443), Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350), In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350)

Belongs to the protein kinase superfamily, Tyr protein kinase family, ROR subfamily


This is Tyrosine-protein kinase transmembrane receptor ROR2 protein, from Human, contains 943 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes, It seems to be required for cartilage and growth plate development (By similarity), Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073), In contrast, has also been shown to have very little tyrosine kinase activity in vitro, May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443)


This is DNA-binding protein creA protein, from Aspergillus nidulans, contains 416 amino acids, has 2 C2H2-type Zinc finger.

Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB, Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter, Also plays a role in response to carbon starvation and the control of extracellular proteases activity

Belongs to the creA/MIG C2H2-type zinc-finger protein family


This is Zinc finger protein SNAI1 protein, from Mouse, contains 264 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration, Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription, Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration, Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription, The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (By similarity), During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292), SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292), Associates with EGR1 and SP1 to mediate 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3', In addition, may also activate the CDKN2B promoter by itself


This is Transcription factor Sp2 protein, from Human, contains 613 amino acids, has 3 C2H2-type Zinc finger.

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites


This is Protein kinase C theta type protein, from Mouse, contains 707 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2, In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1, May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway, In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling, Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization, After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR, During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells, May play a minor role in Th1 response, Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways, In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction, May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex, May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway, Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol, Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1, Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Protein kinase C epsilon type protein, from Human, contains 737 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis, Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts, Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes, Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein, In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact, Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration, In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF, During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA, In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1, During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length, Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3), Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement, May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation, Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol, Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons, Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2,2), In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion, Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production, In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2, May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1, Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546)


This is Programmed cell death protein 1 protein, from Mouse, contains 288 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:10485649, PubMed:11698646, PubMed:11209085, PubMed:21300912), Delivers inhibitory signals upon binding to ligands, such as CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:11015443, PubMed:11224527, PubMed:22641383, PubMed:18287011, PubMed:18641123), Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:22641383), Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (PubMed:11698646, PubMed:22641383), The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (By similarity)


This is Pro-neuregulin-1, membrane-bound isoform protein, from Human, contains 640 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors, The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart, Isoform 10 may play a role in motor and sensory neuron development, Binds to ERBB4 (PubMed:10867024, PubMed:7902537), Binds to ERBB3 (PubMed:20682778), Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4, Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling, Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778), Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity)


This is Transcriptional adapter 2 protein, from Baker's yeast, contains 434 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA, SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation, SLIK is proposed to have partly overlapping functions with SAGA, It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus, ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B


This is Metal-response element-binding transcription factor 2 protein, from Mouse, contains 593 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:20144788, PubMed:21367819, PubMed:21059868, PubMed:23104054, PubMed:22438827), Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (PubMed:20144788), Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (PubMed:21367819), Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (PubMed:21059868), In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (PubMed:21059868), Binds to the metal-regulating-element (MRE) of MT1A gene promoter (PubMed:7772254)


This is Transcription factor Sp4 protein, from Human, contains 784 amino acids, has 3 C2H2-type Zinc finger.

Binds to GT and GC boxes promoters elements, Probable transcriptional activator


This is Transcription factor Sp3 protein, from Human, contains 781 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications, Binds to GT and GC boxes promoter elements, Competes with SP1 for the GC-box promoters, Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping


This is Pre-mRNA-splicing factor SLU7 protein, from Baker's yeast, contains 382 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Essential protein involved in the second catalytic step of pre-mRNA splicing, Involved in the selection of 3'-type splice sites; this selection could be done via a 3'-splice site-binding factor, PRP16


This is Gag polyprotein protein, from SIV-agm.gri, contains 513 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Cyclic AMP-responsive element-binding protein 5 protein, from Human, contains 508 amino acids, has 1 C2H2-type Zinc finger.

Binds to the cAMP response element and activates transcription


This is Interleukin-1 receptor type 1 protein, from Rat, contains 576 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for IL1A, IL1B and IL1RN, After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways, Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits, Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex, Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity)


This is Protein kinase C zeta type protein, from Mouse, contains 592 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in late synaptic long term potentiation phase in CA1 hippocampal cells and long term memory maintenance


This is Zinc finger protein 354A protein, from Rat, contains 576 amino acids, has 13 C2H2-type Zinc finger.

It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration

Belongs to the krueppel C2H2-type zinc-finger protein family


This is COMPASS component SPP1 protein, from Baker's yeast, contains 353 amino acids, has 1 PHD-type Zinc finger.

PHD-type

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation


This is SAGA-associated factor 11 protein, from Baker's yeast, contains 99 amino acids, has 1 SGF11-type Zinc finger.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SGF11 is involved in transcriptional regulation of a subset of SAGA-regulated genes, Within the SAGA complex, participates in a subcomplex with SUS1, SGF73 and UBP8 required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels, It is required to recruit UBP8 and SUS1 into the SAGA complex