This is B- and T-lymphocyte attenuator protein, from Mouse, contains 306 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006), May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044), In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state, In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044)


This is F-box only protein 5 protein, from Mouse, contains 421 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17190794, PubMed:15526037, PubMed:16809773), During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:16809773), During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase, Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment, As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box co-receptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities, Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (By similarity), During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex, Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (PubMed:15526037), Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (PubMed:17190794), Promotes migration and osteogenic differentiation of mesenchymal stem cells (By similarity)


This is CMRF-35-like molecule 4 protein, from Mouse, contains 228 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Acts as an activating receptor in mast cells and macrophages


This is Immunoglobulin superfamily member 5 protein, from Mouse, contains 370 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells, Mediates calcium-independent homophilic cell adhesion, In testis, it may function as a cell adhesion molecule rather than a tight-junction protein, It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells

Belongs to the immunoglobulin superfamily


This is V-set domain containing T-cell activation inhibitor 1 protein, from Mouse, contains 283 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity, When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity, Involved in promoting epithelial cell transformation

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Kin of IRRE-like protein 2 protein, from Mouse, contains 700 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is PHD finger protein MALE MEIOCYTE DEATH 1 protein, from Mouse-ear cress, contains 704 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Probable transcription factor required for chromosome organization and progression during male meiosis (e,g, microsporogenesis) (PubMed:12782723, PubMed:14573517), Necessary for fertility and meiotic progressive compaction of prophase I chromosomes to metaphase I bivalents (PubMed:27385818), Together with JMJ16, promotes gene expression in male meiocytes in an H3K9me3-dependent manner, and contributes to meiotic chromosome condensation by triggering some condensin promoters (e,g, CAP-D3 and CAP-H) (PubMed:32572214, PubMed:27385818)


This is Zinc finger protein ZOP1 protein, from Mouse-ear cress, contains 242 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Nucleic acid-binding protein that promotes Pol IV-dependent small interfering RNA (siRNA) accumulation, DNA methylation and transcriptional silencing, May possess both RNA-directed DNA methylation (RdDM)-dependent and -independent roles in transcriptional silencing, Acts as a pre-mRNA splicing factor that associates with several typical components of the splicing machinery as well as with Pol II


This is E3 ubiquitin-protein ligase BRE1-like 1 protein, from Rice, contains 884 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1, H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is a prerequisite for H3 Lys-4 methylation (H3K4me), It thereby plays a central role in histone code and gene regulation, H2B monoubiquitination (H2BK143ub1), mediated by HUB1, modulates transcriptional regulation of anther development, likely by promoting histone H3K4 dimethylation (H3K4me2) in the chromatin of the key tapetum degradation-related genes C4, CP1 and UDT1


This is E3 ubiquitin-protein ligase TRIM21 protein, from Bovine, contains 469 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2, Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination, Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes, A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome, Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling, Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3, Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway, Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages, Plays a role in the regulation of the cell cycle progression, Enhances the decapping activity of DCP2, Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules, At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified, The common feature of these proteins is their ability to bind HY RNAs,2, Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma, Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy, Regulates also autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability, Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses, Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI, During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation, When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity


This is Aprataxin protein, from Pig, contains 356 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair, Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species, Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined, Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity), Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)


This is Aprataxin protein, from Bovine, contains 356 amino acids, has 1 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase Mdm2 protein, from Cat, contains 491 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome, Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Also acts as a ubiquitin ligase E3 toward itself and ARRB1, Permits the nuclear export of p53/TP53, Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein, Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation, Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53, Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways, Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus, Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation, Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells, Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity), Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity), Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity)


This is Optineurin protein, from Pig, contains 574 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8, Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation, Negatively regulates the induction of IFNB in response to RNA virus infection, Plays a neuroprotective role in the eye and optic nerve, Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52


This is Aprataxin protein, from Human, contains 356 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567), Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567), Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567), Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001), Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)


This is Zinc finger CCCH-type antiviral protein 1 protein, from Human, contains 902 amino acids, has 4 C3H1-type Zinc finger.

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs, Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end, It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end, Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV), Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation, Isoform 1 is a more potent viral inhibitor than isoform 2, Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs)


This is Neuronal growth regulator 1 protein, from Human, contains 354 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May be involved in cell-adhesion, May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity)

Belongs to the immunoglobulin superfamily, IgLON family


This is Protein mono-ADP-ribosyltransferase TIPARP protein, from Human, contains 657 amino acids, has 1 C3H1-type Zinc finger.

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764), Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764)


This is Zinc finger protein 572 protein, from Human, contains 529 amino acids, has 12 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase RNF144B protein, from Human, contains 303 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation, Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism, However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se

Belongs to the RBR family, RNF144 subfamily


This is Tripartite motif-containing protein 46 protein, from Human, contains 759 amino acids, has 1 RING-type 1; degenerate Zinc finger, has 1 RING-type 2; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type 1; degenerate

RING-type 2; degenerate

B box-type

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon, Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons, Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration


This is Zinc finger protein 438 protein, from Human, contains 828 amino acids, has 4 C2H2-type Zinc finger.

Isoform 1 acts as a transcriptional repressor


This is BRCA1-associated protein protein, from Human, contains 592 amino acids, has 1 RING-type Zinc finger, has 1 UBP-type; degenerate Zinc finger.

RING-type

UBP-type; degenerate

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein, Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation, May also act as a cytoplasmic retention protein with a role in regulating nuclear transport


This is Interferon regulatory factor 2-binding protein 2 protein, from Human, contains 587 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427), Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369), Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774), Plays a role in immature B-cell differentiation (PubMed:27016798)


This is B- and T-lymphocyte attenuator protein, from Human, contains 289 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050), May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044), In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state, In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044)


This is E3 ubiquitin-protein ligase SH3RF1 protein, from Human, contains 888 amino acids, has 1 RING-type Zinc finger.

RING-type

(Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity


This is FYVE, RhoGEF and PH domain-containing protein 2 protein, from Human, contains 655 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Activates JNK1 via CDC42 but not RAC1, Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity)


This is THAP domain-containing protein 5 protein, from Human, contains 395 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952), May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560)


This is Allergin-1 protein, from Human, contains 343 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells, Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity)


This is V-set domain-containing T-cell activation inhibitor 1 protein, from Human, contains 282 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity, When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity, Involved in promoting epithelial cell transformation


This is Retinoic acid receptor alpha-B protein, from Zebrafish, contains 458 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is E3 ubiquitin-protein ligase rnf8-A protein, from African clawed frog, contains 540 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites, Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF), H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins, In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation


This is BUB3-interacting and GLEBS motif-containing protein ZNF207 protein, from African clawed frog, contains 452 amino acids, has 2 C2H2-type Zinc finger.

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly, Znf207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets, Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks


This is mRNA decay activator protein ZFP36L2-A protein, from African clawed frog, contains 363 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10751406, PubMed:12748283), Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity), Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity), Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12748283), Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (PubMed:10751406, PubMed:11279239), Required for tubulogenesis during pronephros development (By similarity)


This is Zygotic DNA replication licensing factor mcm6-B protein, from African clawed frog, contains 825 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development, May replace mmcm6 in the mcm2-7 complex


This is Zinc finger and BTB domain-containing protein 16-A protein, from Zebrafish, contains 671 amino acids, has 9 C2H2-type Zinc finger.

Probable transcription factor, Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity), Inhibits neurogenesis


This is E3 ubiquitin-protein ligase rnf8 protein, from Zebrafish, contains 485 amino acids, has 1 RING-type Zinc finger.

RING-type


This is E3 ubiquitin-protein ligase RING2 protein, from Zebrafish, contains 336 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation, H2AK119Ub gives a specific tag for epigenetic transcriptional repression, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility


This is Protein lin-28 homolog A protein, from Zebrafish, contains 202 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism, Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity), 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis, Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization, Suppressor of microRNA (miRNA) biogenesis, including that of let-7, Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase, This results in the terminal uridylation of target pre-miRNAs, Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity), Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins, Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation, Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity)


This is Fez family zinc finger protein 2 protein, from Zebrafish, contains 430 amino acids, has 6 C2H2-type Zinc finger.

Transcription repressor, Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons


This is mRNA decay activator protein ZFP36L2-B protein, from African clawed frog, contains 364 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10751406), Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity), Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity), Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12914788), Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity), Required for tubulogenesis during pronephros development (PubMed:12914788)


This is Zygote arrest protein 1 protein, from Mouse, contains 361 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes (PubMed:36264786), MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth (PubMed:36264786), Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (PubMed:36264786), Binds to the 3'-UTR of maternal mRNAs (PubMed:31598710), Maternal mRNAs stored in the MARDO are translationally repressed (PubMed:36264786), Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation (PubMed:12539046, PubMed:31598710, PubMed:36264786)

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 2 protein, from Mouse, contains 788 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Promotes neurite outgrowth in hippocampal neurons, Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity), May play a role in redistributing DLG4 to the cell periphery


This is E3 ubiquitin-protein ligase Praja-2 protein, from Mouse, contains 707 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Has E2-dependent E3 ubiquitin-protein ligase activity, Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation, Essential for PKA-mediated long-term memory processes, Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype, Plays a role in ciliogenesis by ubiquitinating OFD1


This is Polycomb protein Suz12 protein, from Mouse, contains 741 amino acids, has 1 C2H2-type Zinc finger.

Polycomb group (PcG) protein, Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene, The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity), Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is Junctional adhesion molecule-like protein, from Mouse, contains 379 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells, The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair, Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases, It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair, It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR


This is tRNA dimethylallyltransferase protein, from Mouse, contains 467 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:23289710), Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (By similarity), TRIT1 is therefore required for selenoprotein expression (PubMed:23289710)


This is Diacylglycerol kinase zeta protein, from Mouse, contains 929 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12883552), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:12883552), Also plays an important role in the biosynthesis of complex lipids (Probable), Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species, Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity), The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (PubMed:12883552), By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity), Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (PubMed:27739494), Regulates RASGRP1 activity (By similarity)

Belongs to the eukaryotic diacylglycerol kinase family


This is E3 ubiquitin-protein ligase KCMF1 protein, from Mouse, contains 381 amino acids, has 1 ZZ-type Zinc finger, has 1 C2H2-type Zinc finger.

ZZ-type

Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination


This is PR domain zinc finger protein 4 protein, from Mouse, contains 803 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger.

C2H2-type 6; degenerate

May function as a transcription factor involved in cell differentiation

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is E3 ubiquitin-protein ligase TRIM62 protein, from Mouse, contains 475 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity), E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (By similarity)


This is E3 ubiquitin-protein ligase TRIM56 protein, from Mouse, contains 734 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21074459, PubMed:29426904), In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (PubMed:21074459), Also mediates monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904), Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling (By similarity), Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity)


This is Zinc finger and SCAN domain containing protein 4C protein, from Mouse, contains 506 amino acids, has 4 C2H2-type Zinc finger.

Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency, Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation, Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells


This is Zinc fingers and homeoboxes protein 2 protein, from Rat, contains 836 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor, Represses the promoter activity of the CDC25C gene stimulated by NFYA, May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells, In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex


This is Serine/threonine-protein phosphatase 1 regulatory subunit 10 protein, from Mouse, contains 888 amino acids, has 1 C3H1-type Zinc finger.

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex, The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase, Mediates interaction of WDR82 and PPP1CA, Inhibitor of PPP1CA and PPP1CC phosphatase activities, Has inhibitory activity on PPP1CA only when phosphorylated, Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers


This is Kin of IRRE-like protein 1 protein, from Mouse, contains 789 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Required for proper function of the glomerular filtration barrier, It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:11416156), Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1


This is E3 ubiquitin-protein ligase Trim36 protein, from Mouse, contains 729 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 B box-type Zinc finger.

RING-type; degenerate

B box-type

B box-type

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:19232519), Involved in chromosome segregation and cell cycle regulation (PubMed:19232519), May play a role in the acrosome reaction and fertilization (PubMed:12917430)


This is Hyaluronan and proteoglycan link protein 4 protein, from Mouse, contains 400 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (PubMed:22121037), Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons (PubMed:30125937)

Secreted, extracellular space, extracellular matrix


This is Nanos homolog 1 protein, from Mouse, contains 267 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type

May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets, Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin, Up-regulates the production of MMP14 to promote tumor cell invasion (By similarity), Not essential for normal development


This is Zinc finger and BTB domain-containing protein 24 protein, from Mouse, contains 710 amino acids, has 8 C2H2-type Zinc finger.

May be involved in BMP2-induced transcription


This is E3 ubiquitin-protein ligase TRIM69 protein, from Mouse, contains 500 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus, Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection, In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity, Plays also a role in cataract formation together with TP53, Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination


This is E3 ubiquitin-protein ligase RNF168 protein, from Mouse, contains 565 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage, Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination, Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates, This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1, Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites, Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region, Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)


This is E3 ubiquitin-protein ligase CBL-C protein, from Mouse, contains 496 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome, Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3, Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR, Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation, Promotes ubiquitination of SRC phosphorylated at 'Tyr-424', has the highest ubiquitin ligase activity among CBL family proteins, In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival


This is Leucine-rich repeat and fibronectin type-III domain-containing protein 4 protein, from Mouse, contains 636 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Promotes neurite outgrowth in hippocampal neurons, May play a role in redistributing DLG4 to the cell periphery


This is Zinc finger C3HC-type protein 1 protein, from Mouse, contains 501 amino acids, has 1 C3HC-type Zinc finger.

Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1), Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase, Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity), Overexpression may be able to protect from apoptosis induced by IL-3 withdrawal


This is B box and SPRY domain-containing protein protein, from Mouse, contains 473 amino acids, has 1 B box-type Zinc finger.

B box-type

May regulate epithelial calcium transport by inhibiting TRPV5 activity


This is Neuronal growth regulator 1 protein, from Mouse, contains 348 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May be involved in cell-adhesion, May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain


This is Zinc fingers and homeoboxes protein 3 protein, from Rat, contains 951 amino acids, has 2 C2H2-type Zinc finger.

Acts as a transcriptional repressor, Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation, Is a regulator of podocyte gene expression during primary glomerula disease, Binds to promoter DNA


This is Amphoterin-induced protein 1 protein, from Rat, contains 493 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Promotes growth and fasciculation of neurites from cultured hippocampal neurons, May be involved in fasciculation as well as myelination of developing neural axons, May have a role in regeneration as well as neural plasticity in the adult nervous system, May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (PubMed:12629050), Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity)

Belongs to the immunoglobulin superfamily, AMIGO family


This is Amphoterin-induced protein 1 protein, from Mouse, contains 492 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Promotes growth and fasciculation of neurites from cultured hippocampal neurons, May be involved in fasciculation as well as myelination of developing neural axons, May have a role in regeneration as well as neural plasticity in the adult nervous system, May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity), Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:22056818)


This is Amphoterin-induced protein 2 protein, from Mouse, contains 519 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Required for depolarization-dependent survival of cultured cerebellar granule neurons, May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3, May contribute to signal transduction through its intracellular domain (By similarity)


This is Sialic acid-binding Ig-like lectin 10 protein, from Mouse, contains 688 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) During infection by RNA viruses inhibits RIG-I signaling in macrophages by promoting its CBL-dependent ubiquitination and degradation via PTPN11/SHP-2

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is E3 ubiquitin-protein ligase LRSAM1 protein, from Mouse, contains 727 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity), Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity), Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity)


This is E3 ubiquitin-protein ligase TRIM50 protein, from Mouse, contains 483 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308), In turn, promotes starvation-induced autophagy activation, Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322), Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (PubMed:36178239)


This is Pregnancy-specific glycoprotein 22 protein, from Mouse, contains 475 amino acids, has 3 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like C2-type

May have an angiogenic function during early placental development, Binds to cell-surface heparan sulfate proteoglycans (HSPGs), and stimulates secretion of the proangiogenic factors VEGFA and TGFB from uterine dendritic cells and natural killer cells, Also induces endothelial tube formation in vitro

Belongs to the immunoglobulin superfamily, CEA family


This is Zinc finger FYVE domain-containing protein 1 protein, from Mouse, contains 777 amino acids, has 2 FYVE-type Zinc finger.

FYVE-type

FYVE-type

Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241), Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241), Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity), Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity)


This is E3 ubiquitin-protein ligase CHFR protein, from Mouse, contains 664 amino acids, has 1 RING-type Zinc finger, has 1 PBZ-type Zinc finger.

RING-type

PBZ-type

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons, Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus, Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome, Promotes the ubiquitination and subsequent degradation of AURKA and PLK1, Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation, May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity)


This is Histone acetyltransferase KAT7 protein, from Rat, contains 612 amino acids, has 1 CCHHC-type Zinc finger, has 1 C2HC MYST-type Zinc finger.

CCHHC-type

C2HC MYST-type

Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development, Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation, Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4, H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II, Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (By similarity), H3K14ac is also required for T-cell development (By similarity), KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing, Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange, Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites, Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (By similarity)


This is Zinc finger and BTB domain-containing protein 42 protein, from Mouse, contains 420 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional repressor, Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes

Belongs to the krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily


This is Polynucleotide 3'-phosphatase ZDP protein, from Mouse-ear cress, contains 694 amino acids, has 3 PARP-type Zinc finger.

PARP-type

PARP-type

PARP-type

Nick-sensing 3'-phosphoesterase involved in a base excision repair pathway required for active DNA demethylation, The N-terminal DNA-binding domain binds specifically to gap sites and sharply bends the target DNA, Lacks 5'-kinase activity but is capable of 3'-phosphoglycolate end processing, Inactive on 3'-alpha,beta-unsaturated aldehyde (3'-dRP), Protects partially genes from transcriptional silencing by preventing promoter DNA hypermethylation

In the C-terminal section; belongs to the DNA 3' phosphatase family


This is E3 ubiquitin-protein ligase SINAT3 protein, from Mouse-ear cress, contains 326 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:32786047), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:32786047), It probably triggers the ubiquitin-mediated degradation of different substrates (PubMed:32786047), Modulates directly the ubiquitination and proteasomal-dependent degradation of FREE1, a component of the ESCRT-I complex (PubMed:32786047, PubMed:32753431), Modulates directly the ubiquitination and proteasomal-dependent degradation of ELC/VPS23A, a component of the ESCRT-I complex (PubMed:32753431)

Belongs to the SINA (Seven in absentia) family


This is E3 ubiquitin-protein ligase HOS1 protein, from Mouse-ear cress, contains 927 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1, Acts as a negative regulator of cold signaling pathways (PubMed:16702557), Probably involved in recruiting the NUP107-160 subcomplex of the nuclear pore complex to chromatin (Probable), Controls flowering time in response to ambient temperatures (16 and 23 degrees Celsius) and intermittent cold, probably via the regulation of FT and TSF levels (PubMed:22960247)


This is Dof zinc finger protein DOF4.7 protein, from Mouse-ear cress, contains 246 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence, Involved in the negative regulation of floral organ abscission by binding to the typical DOF 5'-AAAG-3' sequences in the promoter of ADPG2/PGAZAT, and by down-regulating its expression, ADPG2/PGAZAT is an abscission-related and cell wall hydrolyzing polygalacturonase, May act through the interaction with ZFP2, an abscission-related transcription factor


This is Probable E3 ubiquitin-protein ligase LUL3 protein, from Mouse-ear cress, contains 378 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro)

Belongs to the RING-type zinc finger family, LOG2 subfamily


This is Transcription factor IIIA protein, from Mouse-ear cress, contains 412 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 5 C2H2-type Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger, has 1 C2H2-type 7; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 6; degenerate

C2H2-type 7; degenerate

C2H2-type 9; degenerate

Essential protein (PubMed:22353599), Isoform 1 is a transcription activator the binds both 5S rDNA and 5S rRNA and stimulates the transcription of 5S rRNA gene (PubMed:12711688, PubMed:22353599), Isoform 1 regulates 5S rRNA levels during development (PubMed:22353599)


This is Probable E3 ubiquitin-protein ligase ARI12 protein, from Mouse-ear cress, contains 496 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates

Belongs to the RBR family, Ariadne subfamily


This is Dof zinc finger protein DOF5.3 protein, from Mouse-ear cress, contains 257 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity), The PEAR proteins (e,g, DOF2,4, DOF5,1, DOF3,2, DOF1,1, DOF5,6 and DOF5,3) activate gene expression that promotes radial growth of protophloem sieve elements (PubMed:30626969)


This is Zinc finger protein GIS protein, from Mouse-ear cress, contains 253 amino acids, has 1 C2H2-type Zinc finger.

Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin (GA) (PubMed:16679458, PubMed:17507408), Mediates the induction of GL1 expression by GA in inflorescence organs and is antagonized in its action by the DELLA repressor GAI, Acts upstream of the trichome initiation regulators GL1 and GL3, and downstream of the GA signaling repressor SPINDLY (SPY) (PubMed:16679458), Does not play a significant role in the cytokinin response (PubMed:17507408), Controls trichome branching through GA signaling (PubMed:22210898, PubMed:23825141), Acts downstream of the key regulator STICHEL (STI) in an endoreduplication-independent pathway (PubMed:22210898), Controls trichome cell division indirectly by acting downstream of a key endoreduplication regulator SIAMESE (SIM) (PubMed:23825141)


This is Rho guanine nucleotide exchange factor 2 protein, from Dog, contains 986 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Activates Rho-GTPases by promoting the exchange of GDP for GTP, May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer, Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, May stimulate instead the cortical activity of Rac, Inactive toward CDC42, TC10, or Ras-GTPases, Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens, Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase, Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2, Involved in neuronal progenitor cell division and differentiation, Involved in the migration of precerebellar neurons (By similarity), Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (PubMed:12604587)


This is Longitudinals lacking protein, isoforms F/I/K/T protein, from Fruit fly, contains 970 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is RING finger protein unkempt protein, from Fruit fly, contains 599 amino acids, has 5 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

Essential for late larval/early pupal development


This is Modifier of mdg4 protein, from Fruit fly, contains 610 amino acids, has 1 FLYWCH-type Zinc finger.

FLYWCH-type

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators, Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes, Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV), Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops, This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery, Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional, Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents, Isoform H also plays a role in apoptotic regulatory pathways


This is Polycomb group RING finger protein 5 protein, from Human, contains 256 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332), Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity)


This is Amphoterin-induced protein 2 protein, from Human, contains 522 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Required for depolarization-dependent survival of cultured cerebellar granule neurons, May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3, May contribute to signal transduction through its intracellular domain, May be required for tumorigenesis of a subset of gastric adenocarcinomas


This is Immunoglobulin-like domain-containing receptor 1 protein, from Human, contains 546 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027), Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs, Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine, In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity)

Belongs to the immunoglobulin superfamily, LISCH7 family


This is Transcriptional regulator Kaiso protein, from Human, contains 672 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator with bimodal DNA-binding specificity, Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS), Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters, May contribute to the repression of target genes of the Wnt signaling pathway, May also activate transcription of a subset of target genes by the recruitment of CTNND2, Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453)


This is E3 ubiquitin-protein ligase RNF180 protein, from Human, contains 592 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2


This is Retrotransposon-derived protein PEG10 protein, from Human, contains 708 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232), Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232), Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232), Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity), Involved at the immediate early stage of adipocyte differentiation (By similarity), Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232), Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509), May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity)


This is Transcriptional adapter 2-beta protein, from Human, contains 420 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2


This is E3 ubiquitin-protein ligase synoviolin protein, from Human, contains 617 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405), Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558), Also promotes the degradation of normal but naturally short-lived proteins such as SGK, Protects cells from ER stress-induced apoptosis, Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218), Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702), Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity), During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity)


This is RPA-interacting protein protein, from Human, contains 219 amino acids, has 1 RIP-type Zinc finger.

RIP-type

Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta, Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism


This is E3 ubiquitin-protein ligase MARCHF3 protein, from Human, contains 253 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Zinc finger protein 329 protein, from Human, contains 541 amino acids, has 12 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is E3 ubiquitin-protein ligase ZNF598 protein, from Human, contains 904 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger.

RING-type

(Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10 (PubMed:29719242), Poxvirus encoding mRNAs contain unusual 5' poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts (PubMed:29719242)


This is Zinc finger protein 589 protein, from Human, contains 364 amino acids, has 4 C2H2-type Zinc finger.

May play a role in hematopoietic stem/progenitor cell differentiation, May play a role as a DNA binding-dependent transcriptional repressor


This is Tripartite motif-containing protein 74 protein, from Human, contains 250 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type


This is Probable E3 ubiquitin-protein ligase DTX2 protein, from Human, contains 622 amino acids, has 1 RING-type Zinc finger.

RING-type

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context, Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1, Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity


This is Zinc finger and BTB domain-containing protein 46 protein, from Human, contains 589 amino acids, has 2 C2H2-type Zinc finger.

Functions as a transcriptional repressor for PRDM1


This is MORC family CW-type zinc finger protein 1 protein, from Human, contains 984 amino acids, has 1 CW-type Zinc finger.

CW-type

Required for spermatogenesis (By similarity), Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity)


This is Zinc finger protein 410 protein, from Human, contains 478 amino acids, has 5 C2H2-type Zinc finger.

Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730), Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730), May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286), May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215), However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730)


This is Zinc finger CCCH domain-containing protein 18 protein, from Human, contains 953 amino acids, has 1 C3H1-type Zinc finger.


This is Tax1-binding protein 1 protein, from Human, contains 789 amino acids, has 2 UBZ1-type Zinc finger.

Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:30459273, PubMed:29940186, PubMed:30909570), Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191), Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437), Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191), Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772), As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915), Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133)


This is Juxtaposed with another zinc finger protein 1 protein, from Human, contains 243 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918), Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity), Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity), Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity), Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity)


This is Zinc finger C3HC-type protein 1 protein, from Human, contains 502 amino acids, has 1 C3HC-type Zinc finger.

Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1), Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase, Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry, May have an antiapoptotic role in NPM-ALK-mediated signaling events


This is Amphoterin-induced protein 1 protein, from Human, contains 493 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Promotes growth and fasciculation of neurites from cultured hippocampal neurons, May be involved in fasciculation as well as myelination of developing neural axons, May have a role in regeneration as well as neural plasticity in the adult nervous system, May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain, Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1


This is E3 ubiquitin-protein ligase TRIM69 protein, from Human, contains 500 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292), Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644), In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989), Plays also a role in cataract formation together with TP53 (PubMed:30844644), Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644)


This is Lipolysis-stimulated lipoprotein receptor protein, from Human, contains 649 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Probable role in the clearance of triglyceride-rich lipoprotein from blood, Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity), Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity)


This is Zinc finger protein 575 protein, from Human, contains 245 amino acids, has 6 C2H2-type Zinc finger.


This is F-box only protein 11 protein, from Human, contains 927 amino acids, has 1 UBR-type Zinc finger.

UBR-type

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1, The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells, The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit, Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity, SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53


This is V-set and immunoglobulin domain-containing protein 1 protein, from Human, contains 387 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type


This is RNA-binding protein MEX3D protein, from Human, contains 651 amino acids, has 1 RING-type Zinc finger.

RING-type

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms


This is E3 ubiquitin-protein ligase RNF130 protein, from Human, contains 419 amino acids, has 1 RING-type Zinc finger.

RING-type

May have a role during the programmed cell death of hematopoietic cells (By similarity), Acts as an E3 ubiquitin-protein ligase


This is E3 ubiquitin-protein ligase TRIM50 protein, from Human, contains 487 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308), In turn, promotes starvation-induced autophagy activation, Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322), Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity)


This is E3 ubiquitin-protein ligase DTX1 protein, from Human, contains 620 amino acids, has 1 RING-type Zinc finger.

RING-type

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity), Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context, Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1, Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation, Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1


This is Transmembrane protein 25 protein, from Human, contains 366 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

In neurons, modulates the degradation of NMDA receptor GRIN2B subunit, Plays a role in the regulation of neuronal excitability


This is Cilium assembly protein DZIP1 protein, from Human, contains 867 amino acids, has 1 C2H2-type Zinc finger.

Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:19852954, PubMed:23955340, PubMed:27979967, PubMed:32051257), At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (By similarity), Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium (PubMed:27979967), It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (By similarity), Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (By similarity), It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum (PubMed:32051257), Also indirectly involved in heart development through its function in ciliogenesis (PubMed:31118289)

Cytoplasm, cytoskeleton, cilium basal body

Belongs to the DZIP C2H2-type zinc-finger protein family


This is PHD finger protein 13 protein, from Human, contains 300 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Modulates chromatin structure, Required for normal chromosome condensation during the early stages of mitosis, Required for normal chromosome separation during mitosis


This is E3 ubiquitin-protein ligase MARCHF9 protein, from Human, contains 346 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Transcriptional repressor p66-alpha protein, from Human, contains 633 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional repressor (PubMed:12183469, PubMed:16415179), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666), Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179), Efficient repression requires the presence of GATAD2B (PubMed:16415179)


This is Junctional adhesion molecule-like protein, from Human, contains 394 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells, The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair, Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases, It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair, It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR

Belongs to the immunoglobulin superfamily


This is Trem-like transcript 1 protein protein, from Human, contains 311 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor that may play a role in the innate and adaptive immune response


This is Gag polyprotein protein, from SIV-cpz, contains 524 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is F-box only protein 43 protein, from African clawed frog, contains 651 amino acids, has 1 ZBR-type Zinc finger.

ZBR-type

Required to prevent anaphase onset in cytostatic factor-arrested oocytes, Inhibits the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase and prevents cyclin degradation, Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation


This is Muscle, skeletal receptor tyrosine protein kinase protein, from Chicken, contains 947 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle, Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is E3 ubiquitin-protein ligase TRIM65 protein, from Mouse, contains 522 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:31310649, PubMed:34512673), Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs, This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (By similarity), Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade, Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (By similarity), Plays also a role in limitation of inflammation through different mechanisms, First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649), In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673)


This is E3 ubiquitin-protein ligase RNF187 protein, from Mouse, contains 236 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8


This is E3 ubiquitin-protein ligase RNF152 protein, from Mouse, contains 203 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation, Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802), Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation, Induces apoptosis when overexpressed (By similarity)


This is Leukocyte-associated immunoglobulin-like receptor 1 protein, from Mouse, contains 263 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells, Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11, It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation, May also play its inhibitory role independently of SH2-containing phosphatases, Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta, Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion, Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells, Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity)


This is Protein ZNF365 protein, from Mouse, contains 408 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040), Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis (PubMed:23912123), Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth (PubMed:24481677), Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (PubMed:25983680), Involved in the regulation of neurogenesis, Negatively regulates neurite outgrowth, Involved in homologous recombination (HR) repair pathway, Required for proper resolution of DNA double-strand breaks (DSBs) by HR, Is required for recovery of stalled replication forks, and directly contributes to genomic stability, Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (By similarity)

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome


This is Tripartite motif-containing protein 6 protein, from Mouse, contains 488 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218), In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218), Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504), Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhancement of RIGI-mediated innate antiviral immune response (By similarity)


This is Splicing factor U2AF 26 kDa subunit protein, from Mouse, contains 220 amino acids, has 2 C3H1-type Zinc finger.

RNA-binding protein that function as a pre-mRNA splicing factor, Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection, It can functionally substitute for U2AF1 in constitutive splicing and enhancer-dependent splicing, Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts, Also participates in the regulation of alternative pre-mRNA splicing, Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1, Binds to RNA at the AG dinucleotide at the 3'-splice site, Shows a preference for AGC or AGA (PubMed:11739736, PubMed:16819553, PubMed:18460468), Alternative splicing of U2AF1L4 may play a role in connecting the circadian rhythm to changing external cues: may provide a circadian buffering system in central and periphery clocks that allows synchronized adaption to clock-resetting stimuli in order to prevent potentially pathogenic desynchronization (PubMed:24837677)

Belongs to the splicing factor SR family


This is Zinc finger protein 8 protein, from Mouse, contains 572 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional repressor, May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase TRIM23 protein, from Mouse, contains 574 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type; degenerate Zinc finger.

RING-type; degenerate

B box-type; degenerate

Acts as an E3 ubiquitin-protein ligase, Plays an essential role in autophagy activation during viral infection, Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1, In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes

In the C-terminal section; belongs to the small GTPase superfamily, Arf family


This is E3 ubiquitin-protein ligase NRDP1 protein, from Mouse, contains 317 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 SIAH-type; degenerate Zinc finger.

RING-type; degenerate

SIAH-type; degenerate

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins, Polyubiquitinates MYD88 (By similarity), Negatively regulates MYD88-dependent production of pro-inflammatory cytokines, Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus, Promotes also activation of TBK1 and IRF3 (PubMed:19483718), Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors, Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327), Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation, Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis, Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state, The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy, Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970)