This is DNA topoisomerase 1 protein, from Rickettsia typhi (strain ATCC VR-144 / Wilmington), contains 779 amino acids, has 1 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is E3 ubiquitin-protein ligase MSL2 protein, from Mouse, contains 577 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure (By similarity), Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A, This activity is greatly enhanced by heterodimerization with MSL1, H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity)


This is Zinc finger BED domain-containing protein RICESLEEPER 2 protein, from Rice, contains 722 amino acids, has 1 BED-type Zinc finger.

BED-type

Transposase-like protein that is essential for plant growth and development, May regulate global gene expression by recruiting other cellular factors


This is E3 ubiquitin-protein ligase SIRP1 protein, from Rice, contains 323 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Possesses E3 ubiqutin-protein ligase activity in vitro, Acts as negative regulator of salinity stress tolerance mediated by the ubiquitin-proteasome degradation pathway


This is Splicing factor 3A subunit 2 protein, from Rat, contains 471 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex, Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex, Interacts directly with the duplex formed by U2 snRNA and the intron


This is Zinc finger MYND domain-containing protein 10 protein, from Rat, contains 440 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a role in axonemal structure organization and motility, Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity), May act by indirectly regulating transcription of dynein proteins (By similarity)


This is E3 ubiquitin-protein ligase RNF133 protein, from Rat, contains 381 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Has E3 ubiquitin-protein ligase activity


This is Endothelial cell-selective adhesion molecule protein, from Rat, contains 394 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Can mediate aggregation most likely through a homophilic molecular interaction


This is Cell growth-regulating nucleolar protein protein, from Rat, contains 386 amino acids, has 2 C2HC LYAR-type Zinc finger.

C2HC LYAR-type

C2HC LYAR-type

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs, Also acts at the level of transcription regulation, Along with PRMT5, binds embryonic globin promoter (By similarity), Represses the expression of embryonic globin Hbb-y gene (By similarity), In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41, Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity), Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity), In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity), Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells, Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity)


This is Zinc finger protein 660 protein, from Human, contains 331 amino acids, has 10 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Terminal uridylyltransferase 3 protein, from Trypanosoma brucei brucei, contains 889 amino acids, has 1 C2H2-type; atypical Zinc finger.

C2H2-type; atypical

Terminal uridylyltransferase which catalyzes the addition of Us to the 3'-hydroxyl group of single-stranded RNAs (PubMed:15304317), Does not mediate RNA-independent UTP polymerization (PubMed:15304317)

Belongs to the DNA polymerase type-B-like family


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yeast, contains 622 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)

Belongs to the Dus family, Dus3 subfamily


This is Vacuolar protein sorting-associated protein 27 protein, from Yeast, contains 565 amino acids, has 1 FYVE-type; degenerate Zinc finger.

FYVE-type; degenerate

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yeast, contains 665 amino acids, has 2 C3H1-type Zinc finger.


This is Zinc finger protein Pegasus protein, from Zebrafish, contains 419 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Ubiquitin carboxyl-terminal hydrolase 22-B protein, from African clawed frog, contains 523 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA, Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator, Recruited to specific gene promoters by activators, where it is required for transcription (By similarity)

Belongs to the peptidase C19 family, UBP8 subfamily


This is E3 ubiquitin-protein ligase CBL-B protein, from Western clawed frog, contains 982 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome


This is AN1-type zinc finger protein 6 protein, from Rat, contains 223 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger.

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis, Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1, Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6, In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)


This is Probable E3 ubiquitin-protein ligase RNF144A-B protein, from Zebrafish, contains 293 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates

Belongs to the RBR family, RNF144 subfamily


This is Retinoic acid receptor RXR-gamma-B protein, from Zebrafish, contains 452 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is DNA replication licensing factor mcm2 protein, from Western clawed frog, contains 884 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, Required for the entry in S phase and for cell division


This is TNF receptor-associated factor 6-B protein, from African clawed frog, contains 556 amino acids, has 1 RING-type; degenerate Zinc finger, has 2 TRAF-type Zinc finger.

RING-type; degenerate

TRAF-type

TRAF-type

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2, Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation

Belongs to the TNF receptor-associated factor family, A subfamily


This is Zinc finger protein 470 protein, from Human, contains 717 amino acids, has 17 C2H2-type Zinc finger.


This is DNA replication licensing factor MCM6 protein, from Rice, contains 830 amino acids, has 1 C4-type Zinc finger.

Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yeast, contains 640 amino acids, has 2 C3H1-type Zinc finger.


This is Cell wall transcription factor ACE2 protein, from Yeast, contains 703 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis, Regulates expression of genes involved in cell separation or other cell wall genes, Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence


This is Transcription elongation factor SPT4 protein, from Yeast, contains 102 amino acids, has 1 C4-type Zinc finger.

The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing, This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity)


This is Postreplication repair E3 ubiquitin-protein ligase RAD18 protein, from Yeast, contains 411 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group, Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA


This is Vacuolar protein sorting-associated protein 27 protein, from Yeast, contains 603 amino acids, has 1 FYVE-type; atypical Zinc finger.

FYVE-type; atypical


This is E3 ubiquitin-protein ligase BRE1 protein, from Yeast, contains 693 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation


This is DNA topoisomerase 1 protein, from Staphylococcus aureus (strain MSSA476), contains 689 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone


This is DNA topoisomerase 1 protein, from Staphylococcus aureus (strain MRSA252), contains 689 amino acids, has 3 C4-type Zinc finger.


This is DNA replication licensing factor mcm4 protein, from Western clawed frog, contains 863 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity


This is E3 ubiquitin-protein ligase makorin-2 protein, from Western clawed frog, contains 418 amino acids, has 4 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity), Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway (By similarity), Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression (By similarity)


This is N-lysine methyltransferase SMYD2-B protein, from African clawed frog, contains 430 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is E3 ubiquitin-protein ligase rnf146 protein, from African clawed frog, contains 314 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins, Neuroprotective protein, Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest, Promotes cell survival after gamma-irradiation, Facilitates DNA repair


This is Early growth response protein 1-A protein, from African clawed frog, contains 497 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional regulator, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity), Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity), Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia, Plays a role in the regulation of cell survival, proliferation and cell death, Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity), Plays a role in regulating the expression of circadian clock genes (By similarity)

Belongs to the EGR C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase CBL-B-A protein, from African clawed frog, contains 918 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome


This is E3 ubiquitin-protein transferase MAEA protein, from African clawed frog, contains 396 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, MAEA is required for normal cell proliferation, The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity), Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity), Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity), Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis, Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity), May contribute to nuclear architecture and cells division events (By similarity)


This is Protein Jade-3 protein, from Mouse, contains 823 amino acids, has 2 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity


This is Leukocyte-associated immunoglobulin-like receptor 2 protein, from Human, contains 152 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type


This is Zinc finger protein 425 protein, from Human, contains 752 amino acids, has 19 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase RNF114 protein, from Pig, contains 228 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates, In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity, Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3, May promote the ubiquitination of TRAF6 as well, Acts also as a negative regulator of T-cell activation, Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation, Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C, This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence, May play a role in spermatogenesis (By similarity), Inhibits classical swine fever virus replication by mediating 'K27'-linked ubiquitination of viral NS4B and inducing its degradation via the proteasome (PubMed:31413123)


This is E3 ubiquitin-protein ligase RNF114 protein, from Chimpanzee, contains 228 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type

E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates, In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity, Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3, May promote the ubiquitination of TRAF6 as well, Acts also as a negative regulator of T-cell activation, Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation, Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C, This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence, May play a role in spermatogenesis


This is E3 ubiquitin-protein ligase RNF114 protein, from Rat, contains 229 amino acids, has 1 RING-type Zinc finger, has 1 C2HC RNF-type Zinc finger.

RING-type

C2HC RNF-type


This is GATA transcription factor 15 protein, from Rice, contains 279 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Probable transcription factor that regulates organogenesis during transition from the vegetative to the reproductive phase, Regulates the expression of CYP78A11/PLA1, HD3A and MADS1 during reproductive development in rice, May act upstream of CYP78A11/PLA1 during panicle development, Acts independently of the photoperiodic and gibberellin signaling pathways

Belongs to the type IV zinc-finger family, Class B subfamily


This is E3 ubiquitin ligase TRIM40 protein, from Rat, contains 247 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response, Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation, Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation


This is Formamidopyrimidine-DNA glycosylase protein, from Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100), contains 270 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is PAN2-PAN3 deadenylation complex subunit PAN3 protein, from Neosartorya fumigata, contains 662 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1

Belongs to the protein kinase superfamily, PAN3 family


This is Follistatin-related protein 4 protein, from Human, contains 842 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like


This is E3 ubiquitin-protein ligase ATL76 protein, from Mouse-ear cress, contains 225 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro

Belongs to the RING-type zinc finger family, ATL subfamily


This is ERAD-associated E3 ubiquitin-protein ligase HRD1B protein, from Mouse-ear cress, contains 460 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD), Targets the misfolded LRR receptor kinase BRI1, Functions redundantly with HRD3A


This is E3 ubiquitin-protein ligase CBL-B-B protein, from African clawed frog, contains 764 amino acids, has 1 RING-type Zinc finger.

RING-type


This is E3 ubiquitin-protein ligase synoviolin A protein, from African clawed frog, contains 605 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation, Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins, Also promotes the degradation of normal but naturally short-lived proteins, Protects cells from ER stress-induced apoptosis, Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (By similarity)


This is E3 ubiquitin-protein ligase arkadia-B protein, from African clawed frog, contains 959 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity), Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP, Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP, Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity), The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity)


This is Zinc finger protein 366 protein, from Mouse, contains 746 amino acids, has 11 C2H2-type Zinc finger.

Has transcriptional repression activity, Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases


This is Zinc finger and SCAN domain-containing protein 25 protein, from Human, contains 544 amino acids, has 6 C2H2-type Zinc finger, has 1 C2H2-type 7; degenerate Zinc finger.

C2H2-type 7; degenerate

May be involved in transcriptional regulation


This is Ubiquitin carboxyl-terminal hydrolase 44-A protein, from African clawed frog, contains 690 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset, Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity)

Belongs to the peptidase C19 family, USP44 subfamily


This is Mitochondrial ubiquitin ligase activator of nfkb 1 protein, from African clawed frog, contains 353 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology, Promotes mitochondrial fragmentation and influences mitochondrial localization, Inhibits cell growth, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Ubiquitin thioesterase zranb1-B protein, from African clawed frog, contains 701 amino acids, has 3 RanBP2-type Zinc finger.

Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity), Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity), Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity), Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity), Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity), Required in the stress fiber dynamics and cell migration (By similarity)


This is E3 ubiquitin-protein ligase arih1l protein, from Zebrafish, contains 533 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3

Belongs to the RBR family, Ariadne subfamily


This is Transcription factor Sp9 protein, from Zebrafish, contains 439 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor which plays a key role in limb development, Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is DNA replication licensing factor mcm7 protein, from Western clawed frog, contains 720 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity)


This is CXXC-type zinc finger protein 4 protein, from Mouse, contains 198 amino acids, has 1 CXXC-type Zinc finger.

CXXC-type

Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (PubMed:11113207), Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)


This is E3 ubiquitin-protein ligase MARCHF5 protein, from Zebrafish, contains 289 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission, May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control


This is Pre-mRNA-splicing factor RBM22 protein, from Zebrafish, contains 425 amino acids, has 1 C3H1-type Zinc finger.

Required for pre-mRNA splicing as component of the activated spliceosome, Involved in the first step of pre-mRNA splicing, Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity), Required for normal early embryogenesis (PubMed:20013661)


This is Transcription factor Sp8 protein, from Zebrafish, contains 437 amino acids, has 3 C2H2-type Zinc finger.


This is General transcription factor IIH subunit 2-like protein protein, from Human, contains 395 amino acids, has 1 C4-type Zinc finger.

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II


This is Zygotic DNA replication licensing factor mcm6 protein, from Western clawed frog, contains 823 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development, May replace mmcm6 in the mcm2-7 complex (By similarity)


This is E3 ubiquitin-protein ligase CHFR protein, from Western clawed frog, contains 626 amino acids, has 1 RING-type Zinc finger, has 1 PBZ-type Zinc finger.

RING-type

PBZ-type

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons, Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus, Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome, May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress


This is Zinc finger protein 280C protein, from Mouse, contains 742 amino acids, has 5 C2H2-type Zinc finger.


This is Peroxynitrite isomerase THAP4 protein, from Mouse, contains 569 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate, Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively), Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region

In the C-terminal section; belongs to the nitrobindin family


This is E3 ubiquitin-protein ligase znrf1 protein, from Zebrafish, contains 215 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that plays a role in neuron cells differentiation, Plays a role in the establishment and maintenance of neuronal transmission and plasticity


This is B box and SPRY domain-containing protein protein, from Rat, contains 448 amino acids, has 1 B box-type Zinc finger.

B box-type

May regulate epithelial calcium transport by inhibiting TRPV5 activity


This is Ubiquitin carboxyl-terminal hydrolase 49 protein, from Mouse, contains 685 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing, Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity)


This is Zinc finger protein 82 protein, from Mouse, contains 530 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 5; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase RNF185 protein, from Zebrafish, contains 194 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination, Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation, Protects cells from ER stress-induced apoptosis, Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway, Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity, Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity)


This is Embigin protein, from Human, contains 327 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions, Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology, Delays the retraction of terminal sprouts following re-innervation of denervated endplates, May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity)


This is Zinc finger protein 513 protein, from Mouse, contains 541 amino acids, has 8 C2H2-type Zinc finger.

Transcriptional regulator that plays a role in retinal development and maintenance


This is E3 ubiquitin-protein ligase DTX4 protein, from Mouse, contains 616 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity), Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations


This is Zinc finger protein 613 protein, from Human, contains 617 amino acids, has 12 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase ZNF598 protein, from Zebrafish, contains 953 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains, ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs, Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation, Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10, Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides


This is Endoplasmic reticulum junction formation protein lunapark-B protein, from Zebrafish, contains 402 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology, Involved in the stabilization of nascent three-way ER tubular junctions within the ER network, May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network (By similarity)


This is Ras GTPase-activating protein 4 protein, from Mouse, contains 802 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium, Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis, Isoform 2 activates the Ras pathway and promotes RANKL shedding by modulating the expression of MMP14


This is Tripartite motif-containing protein 72 protein, from African clawed frog, contains 477 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites, Specifically binds phosphatidylserine, Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site, This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation, Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity)


This is Nuclear receptor subfamily 2 group F member 1-B protein, from Zebrafish, contains 389 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Putative transcription factor that is required in photoreceptor cells precursors during eye development


This is Leukocyte immunoglobulin-like receptor subfamily A member 6 protein, from Human, contains 481 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May act as receptor for class I MHC antigens


This is B- and T-lymphocyte attenuator protein, from Rat, contains 308 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2, May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14, In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state, In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells


This is Cell surface glycoprotein CD200 receptor 2 protein, from Human, contains 271 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

May be a receptor for the CD200/OX2 cell surface glycoprotein


This is Steroid hormone receptor ERR1 protein, from Dog, contains 422 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3', Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter, May function as a modulator of the estrogen signaling pathway in the uterus, Induces the expression of PERM1 in the skeletal muscle (By similarity)

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is GATA transcription factor 19 protein, from Mouse-ear cress, contains 211 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters, Regulates both flower and shoot apical meristem (SAM) development, especially for establishing organ boundaries in shoots and flowers, probably by controlling the number and position of WUS-expressing cells (PubMed:23335616, PubMed:25077795)


This is Zinc finger protein JAGGED-like protein, from Mouse-ear cress, contains 207 amino acids, has 1 C2H2-type Zinc finger.

Acts with JAG to promote growth and patterning in stamens and carpels, Promotes the growth of the abaxial and adaxial sides of floral organs, Promotes the growth of the pollen-bearing microsporangia in anthers, the carpel walls of the gynoecium and the establishment of the correct number of cell layers in carpel walls, Promotes leaf blade growth and trichome development


This is Zinc finger CCCH domain-containing protein 15 protein, from Rat, contains 426 amino acids, has 2 C3H1-type Zinc finger.

Protects DRG1 from proteolytic degradation, Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions


This is Zinc finger protein 503 protein, from Zebrafish, contains 563 amino acids, has 1 C2H2-type Zinc finger.

Required for segmental gene expression during hindbrain development, May function as a transcriptional repressor


This is Myelin protein zero-like protein 3 protein, from Human, contains 235 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Leucine-rich repeat neuronal protein 1 protein, from Human, contains 716 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type


This is Trem-like transcript 4 protein protein, from Human, contains 200 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Positively regulates Toll-like receptor TLR7 signaling in macrophages


This is Myelin protein P0 protein, from Horse, contains 248 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system, It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction


This is Cell surface glycoprotein CD200 receptor 2 protein, from Mouse, contains 249 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

According to PubMed:15187158 it is a receptor for the CD200 cell surface glycoprotein, According to PubMed:16081818 it is not a receptor for the CD200/OX2 cell surface glycoprotein, Involved in the recruitment or surface expression of the TYROBP receptor


This is E3 ubiquitin-protein ligase RNF130 protein, from Rat, contains 419 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as an E3 ubiquitin-protein ligase (By similarity), May have a role during the programmed cell death of hematopoietic cells


This is Zinc finger protein 653 protein, from Mouse, contains 615 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional repressor, May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity (By similarity)


This is PHD finger protein EHD3 protein, from Rice, contains 563 amino acids, has 3 PHD-type Zinc finger.

PHD-type

PHD-type

PHD-type

Probable transcription factor involved in the regulation of floral induction under long day (LD) conditions, Promotes photoperiodic flowering by repressing GHD7, a major floral repressor, Seems to function independently of HD1


This is Differentially expressed in FDCP 8 homolog protein, from Human, contains 512 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts, Involved in bone resorption


This is Zinc finger protein 574 protein, from Human, contains 896 amino acids, has 18 C2H2-type Zinc finger, has 1 C2H2-type 10; degenerate Zinc finger, has 1 C2H2-type 15; degenerate Zinc finger.

C2H2-type 10; degenerate

C2H2-type 15; degenerate

May be involved in transcriptional regulation


This is NF-X1-type zinc finger protein NFXL1 protein, from Human, contains 911 amino acids, has 1 RING-type; atypical Zinc finger, has 10 NF-X1-type Zinc finger.

RING-type; atypical


This is Lateral signaling target protein 2 homolog protein, from Mouse, contains 905 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Negative regulator of epidermal growth factor receptor (EGFR) signaling, Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity)


This is Zinc finger protein 662 protein, from Human, contains 426 amino acids, has 8 C2H2-type Zinc finger.


This is Tripartite motif-containing protein 67 protein, from Human, contains 783 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type 1; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type; degenerate

B box-type 1; degenerate

B box-type


This is Pleckstrin homology domain-containing family M member 3 protein, from Human, contains 761 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in skeletal muscle differentiation, May act as a scaffold protein for AKT1 during muscle differentiation


This is Squamosa promoter-binding-like protein 9 protein, from Mouse-ear cress, contains 375 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'


This is Ciliary neurotrophic factor receptor subunit alpha protein, from Dog, contains 372 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to CNTF, The alpha subunit provides the receptor specificity (By similarity)

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Formamidopyrimidine-DNA glycosylase protein, from Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough), contains 365 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Formamidopyrimidine-DNA glycosylase protein, from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA), contains 271 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is Transcription elongation factor SPT4 protein, from Yeast, contains 102 amino acids, has 1 C4-type Zinc finger.

The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing, This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity)


This is Vacuolar protein sorting-associated protein 27 protein, from Yeast, contains 604 amino acids, has 1 FYVE-type; atypical Zinc finger.

FYVE-type; atypical

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane


This is E3 ubiquitin-protein ligase BRE1 protein, from Yeast, contains 643 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Yeast, contains 647 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)

Belongs to the Dus family, Dus3 subfamily


This is N-acetyltransferase ECO1 protein, from Yeast, contains 266 amino acids, has 1 CCHH-type Zinc finger.

CCHH-type

Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together, In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase, Acts by acetylating the cohesin complex component SMC3 (By similarity)

Belongs to the acetyltransferase family, ECO subfamily


This is Chromatin modification-related protein YNG2 protein, from Yeast, contains 285 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair, Involved in cell cycle progression and meiosis (By similarity)


This is Postreplication repair E3 ubiquitin-protein ligase RAD18 protein, from Yeast, contains 443 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger.

RING-type

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group, Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA


This is Peroxisome biogenesis factor 2 protein, from Social amoeba, contains 423 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling, The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane, PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase, PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol


This is GATA zinc finger domain-containing protein 3 protein, from Social amoeba, contains 587 amino acids, has 1 GATA-type Zinc finger.

GATA-type


This is Transcriptional adapter ADA2 protein, from Rice, contains 567 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity), The exact mechanism of action is not yet known (By similarity), ADA2 and GCN5 function to acetylate nucleosomes, opening up the promoter region (PubMed:28487409), The ADA2-GCN5 histone acetyltransferase (HAT) module is recruited by WOX11 to regulate crown root cell proliferation and stem cell maintenance of root meristem (PubMed:28487409), The ADA2-GCN5 HAT module together with WOX11 targets and regulates a set of root-specific genes involved in carbon metabolism, cell wall biosynthesis, and auxin transport and response (PubMed:28487409)


This is Serine/threonine-protein phosphatase 1 regulatory subunit 10 protein, from Pig, contains 925 amino acids, has 1 C3H1-type Zinc finger.

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex, The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase, Mediates interaction of WDR82 and PPP1CA, Inhibitor of PPP1CA and PPP1CC phosphatase activities, Has inhibitory activity on PPP1CA only when phosphorylated, Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity)


This is Protein DROOPING LEAF protein, from Rice, contains 194 amino acids, has 1 C4-type Zinc finger.

Regulates carpel specification in flower development, Severe or intermediate mutation in DL causes complete or partial homeotic conversion of carpels into stamens without affecting the identities of other floral organs, Interacts antagonistically with class B genes and controls floral meristem determinacy, Regulates midrib formation in leaves probably by inducing cell proliferation in the central region of the leaf


This is E3 ubiquitin-protein ligase hel2 protein, from Fission yeast, contains 732 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains, Activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs, Acts as a ribosome collision sensor: specifically recognizes and binds collided ribosome and ubiquitinates the 40S ribosomal proteins rps20/uS10 and rps3/uS3, Catalyzes 'Lys-63'-linked polyubiquitination of rps20/uS10, promoting recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides


This is Transcriptional activator VP30 protein, from ZEBOV, contains 288 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical

Multifunctional protein that acts as a viral transcriptional activator, Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription, Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA, Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures, Assists also stop-start transcription at gene junctions to promote transcription of downstream genes, Interaction with NP plays a critical role in transcription initiation by recognizing the RNA stem loop (By similarity), Interaction with host RBBP6 interferes with NP-VP30 interaction and inhibits viral RNA synthesis (PubMed:30550789), Also acts as a suppressor of RNA silencing by interacting with host DICER1 and TARBP2/TRBP (PubMed:21228243)

Belongs to the filoviridae transcriptional activator VP30 family


This is RING finger containing E3 ubiquitin-protein ligase WSV222 protein, from WSSV, contains 844 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2E1/UBCH6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates ubiquitination of host tumor-suppressor-like protein (TSL) targeting it for degradation, Might function as an anti-apoptosis protein by counteracting TSL-induced apoptosis


This is DNA topoisomerase 1 protein, from Staphylococcus aureus (strain N315), contains 689 amino acids, has 3 C4-type Zinc finger.

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand, The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone

Belongs to the type IA topoisomerase family


This is Poly [ADP-ribose] polymerase 1 protein, from Rice, contains 977 amino acids, has 2 PARP-type Zinc finger.

PARP-type

PARP-type

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity)


This is Zinc finger protein GLIS2 homolog protein, from Fruit fly, contains 384 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Transcription factor which represses a set of lipase genes involved in fat catabolism

Belongs to the GLI C2H2-type zinc-finger protein family


This is RING finger protein 44 protein, from Human, contains 432 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical


This is Zinc finger protein 771 protein, from Human, contains 317 amino acids, has 8 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Endogenous retrovirus group K member 6 Gag polyprotein protein, from Human, contains 666 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle, During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell, Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA, Endogenous Gag proteins may have kept, lost or modified their original function during evolution

Belongs to the beta type-B retroviral Gag protein family, HERV class-II K(HML-2) gag subfamily


This is Transposable element P transposase protein, from Fruit fly, contains 751 amino acids, has 1 THAP-type Zinc finger.

THAP-type

P-element transposase that specifically mediates transposition of P-elements, Mediates both; precise and imprecise excision


This is Formamidopyrimidine-DNA glycosylase protein, from Vibrio vulnificus (strain YJ016), contains 269 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Formamidopyrimidine-DNA glycosylase protein, from Gloeobacter violaceus (strain ATCC 29082 / PCC 7421), contains 284 amino acids, has 1 FPG-type Zinc finger.

FPG-type


This is DNA replication licensing factor Mcm6 protein, from African malaria mosquito, contains 814 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity


This is Zinc finger protein 367 protein, from Human, contains 350 amino acids, has 2 C2H2-type Zinc finger.

Transcriptional activator, Isoform 1 may be involved in transcriptional activation of erythroid genes


This is PAN2-PAN3 deadenylation complex subunit pan3 protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 656 amino acids, has 1 C3H1-type Zinc finger.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pabp-1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by rgb-30/xrn1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, par-2/pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit par-1/pan2 to mRNA via its interaction with RNA and with pabp-1


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 737 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)


This is E3 ubiquitin-protein ligase RNF25 protein, from Zebrafish, contains 513 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity), May also acts as a positive regulator of the Wnt signaling (PubMed:27007149)


This is E3 ubiquitin-protein transferase MAEA protein, from Zebrafish, contains 396 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, MAEA is required for normal cell proliferation, The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity), Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity), Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity), Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis, Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity), May contribute to nuclear architecture and cells division events (By similarity)


This is E3 ubiquitin-protein ligase RNF170 protein, from Zebrafish, contains 266 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor (ITPR) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway, Also involved in ITPR turnover in resting cells


This is E3 ubiquitin-protein ligase RNF12-B protein, from African clawed frog, contains 757 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner, Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the formation of a ldb1-lhx1/lim1 complex, Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1 (By similarity)


This is Aprataxin protein, from African clawed frog, contains 347 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair, Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species, Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined, Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity), Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)


This is Fibroblast growth factor receptor-like 1 protein, from Chicken, contains 487 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Has a negative effect on cell proliferation


This is Netrin receptor UNC5C protein, from Chicken, contains 931 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance (By similarity), Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity), Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977)


This is Zygote arrest protein 1.S protein, from African clawed frog, contains 295 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:23827238), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of maternal mRNAs in immature oocytes, inhibiting their translation (PubMed:23827238)

Cytoplasm, Cytoplasmic ribonucleoprotein granule


This is Cytoplasmic 60S subunit biogenesis factor ZNF622 protein, from Rat, contains 386 amino acids, has 2 U1-type Zinc finger.

Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit


This is Zinc finger CCCH domain-containing protein 14 protein, from Rat, contains 736 amino acids, has 5 C3H1-type Zinc finger.

Involved in poly(A) tail length control in neuronal cells, Binds the polyadenosine RNA oligonucleotides


This is Zinc finger protein 24 protein, from Rat, contains 368 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor required for myelination of differentiated oligodendrocytes, Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state, In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle, Specifically binds to the 5'-TCAT-3' DNA sequence, Has transcription repressor activity in vitro (By similarity)


This is Splicing factor U2AF 26 kDa subunit protein, from Rat, contains 220 amino acids, has 2 C3H1-type Zinc finger.

RNA-binding protein that function as a pre-mRNA splicing factor, Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection, Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts, Also participates in the regulation of alternative pre-mRNA splicing, Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1, Binds to RNA at the AG dinucleotide at the 3'-splice site, Shows a preference for AGC or AGA

Belongs to the splicing factor SR family


This is Nexilin protein, from Mouse, contains 607 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Involved in regulating cell migration through association with the actin cytoskeleton, Has an essential role in the maintenance of Z line and sarcomere integrity


This is Fibroblast growth factor receptor-like 1 protein, from Rat, contains 529 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is F-box only protein 11 protein, from Rat, contains 843 amino acids, has 1 UBR-type Zinc finger.

UBR-type

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1, The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells, The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit, Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity, SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG


This is Butyrophilin-like protein 1 protein, from Mouse, contains 509 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Zygote arrest protein 1 protein, from Rat, contains 361 amino acids, has 1 3CxxC-type Zinc finger.

mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes, MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth, Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs, Binds to the 3'-UTR of maternal mRNAs, Maternal mRNAs stored in the MARDO are translationally repressed, Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation


This is Transcription factor MYBS3 protein, from Rice, contains 318 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Transcription repressor that binds to 5'-TATCCA-3' elements in gene promoters, Contributes to the sugar-repressed transcription of promoters containing SRS or 5'-TATCCA-3' elements, Transcription repressor involved in a cold stress response pathway that confers cold tolerance, Suppresses the DREB1-dependent signaling pathway under prolonged cold stress, DREB1 responds quickly and transiently while MYBS3 responds slowly to cold stress, They may act sequentially and complementarily for adaptation to short- and long-term cold stress (PubMed:20130099)


This is Squamosa promoter-binding-like protein 8 protein, from Rice, contains 416 amino acids, has 1 SBP-type Zinc finger.

SBP-type

Probable transcription factor that plays an important role in building the laminar joint between leaf blade and leaf sheath boundary, thereby controlling ligule and auricle development


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like protein, from Rice, contains 685 amino acids, has 1 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs, Specifically modifies U47 in cytoplasmic tRNAs (By similarity), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)


This is Probable E3 ubiquitin-protein ligase HIP1 protein, from Rice, contains 667 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable E3 ubiquitin-protein ligase that functions downstream of HAL3 and is required for HAL3-regulated plant growth, Activation of HIP1 by HAL3 may lead to the degradation of cell cycle suppressors, resulting in enhancement of cell division and plant growth

Belongs to the RING-type zinc finger family


This is Interleukin-1 receptor accessory protein-like 1 protein, from Bornean orangutan, contains 696 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel, May activate the MAP kinase JNK (By similarity), Plays a role in neurite outgrowth (By similarity), During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity)

Belongs to the interleukin-1 receptor family


This is E3 ubiquitin-protein ligase TRIM15 protein, from Chimpanzee, contains 465 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis, Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2, Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN, Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS, Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1, Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm, Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs)


This is Tripartite motif-containing protein 26 protein, from Chimpanzee, contains 539 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs), Plays also a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA, Promotes nuclear IRF3 ubiquitination and proteasomal degradation, Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1, Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling, In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation, Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein, Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity), Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity)


This is Serine/threonine-protein phosphatase 1 regulatory subunit 10 protein, from Chimpanzee, contains 940 amino acids, has 1 C3H1-type Zinc finger.

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex, The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase, Mediates interaction of WDR82 and PPP1CA, Inhibitor of PPP1CA and PPP1CC phosphatase activities, Has inhibitory activity on PPP1CA only when phosphorylated, Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity)


This is TRMT1-like protein protein, from Human, contains 733 amino acids, has 1 C2H2-type Zinc finger.

May play a role in motor coordination and exploratory behavior

Belongs to the class I-like SAM-binding methyltransferase superfamily, Trm1 family


This is Zinc finger protein 551 protein, from Human, contains 670 amino acids, has 14 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger protein 550 protein, from Human, contains 422 amino acids, has 8 C2H2-type Zinc finger.


This is MAM domain-containing glycosylphosphatidylinositol anchor protein 2 protein, from Human, contains 956 amino acids, has 6 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

May be involved in cell-cell interactions


This is Zinc finger and SCAN domain-containing protein 2 protein, from Human, contains 614 amino acids, has 14 C2H2-type Zinc finger.

May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis


This is Endoplasmic reticulum junction formation protein lunapark-A protein, from Zebrafish, contains 393 amino acids, has 1 C4-type; plays a role in ER morphology Zinc finger.

C4-type; plays a role in ER morphology

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology, Involved in the stabilization of nascent three-way ER tubular junctions within the ER network, May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network (By similarity)


This is E3 ubiquitin-protein ligase rnf146 protein, from Zebrafish, contains 364 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation, May regulate many important biological processes, such as cell survival and DNA damage response, Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins, Neuroprotective protein, Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest, Promotes cell survival after gamma-irradiation, Facilitates DNA repair


This is Ubiquitin carboxyl-terminal hydrolase 44 protein, from Zebrafish, contains 695 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinase that plays a key role in the spindle assembly checkpoint by preventing premature anaphase onset, Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity)

Belongs to the peptidase C19 family, USP44 subfamily


This is Protein Mdm4 protein, from Zebrafish, contains 496 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain


This is E3 ubiquitin-protein ligase Siah1 protein, from Zebrafish, contains 282 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, It probably triggers the ubiquitin-mediated degradation of different substrates

Belongs to the SINA (Seven in absentia) family


This is E3 ubiquitin-protein ligase RING2-B protein, from African clawed frog, contains 343 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation, H2AK119Ub gives a specific tag for epigenetic transcriptional repression, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility


This is Zinc finger protein 703-A protein, from African clawed frog, contains 534 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters (By similarity), Regulates cell adhesion, migration and proliferation (By similarity), Involved in specification of the lateral neural plate border (NPB) (PubMed:28716930), May be required for segmental gene expression during hindbrain development (By similarity)


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like protein, from African clawed frog, contains 640 amino acids, has 2 C3H1-type Zinc finger.

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs), Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs, Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation


This is DNA replication licensing factor mcm7-B protein, from African clawed frog, contains 720 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity)


This is E3 SUMO-protein ligase NSE2 protein, from African clawed frog, contains 238 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination, Is not be required for the stability of the complex, The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks, The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components, Required for recruitment of telomeres to PML nuclear bodies, SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity)


This is N-lysine methyltransferase SMYD2-A protein, from African clawed frog, contains 430 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Protein DBF4 homolog A protein, from African clawed frog, contains 661 amino acids, has 1 DBF4-type Zinc finger.

Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation, Not required during the initiation of DNA replication in egg and during early embryonic development but is required later and throughout development, The complex cdc7-dbf4a phosphorylates mcm2 subunit


This is E3 ubiquitin-protein ligase synoviolin protein, from Zebrafish, contains 625 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation, Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins, Also promotes the degradation of normal but naturally short-lived proteins, Protects cells from ER stress-induced apoptosis, Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (By similarity)


This is Synaptotagmin-like protein 5 protein, from Mouse, contains 753 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

May act as Rab effector protein and play a role in vesicle trafficking, Binds phospholipids (By similarity)


This is E3 ubiquitin-protein ligase MARCHF4 protein, from Mouse, contains 409 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is PHD finger protein 24 protein, from Mouse, contains 400 amino acids, has 1 PHD-type Zinc finger.

PHD-type


This is tRNA endonuclease ANKZF1 protein, from Mouse, contains 748 amino acids, has 1 C2H2-type Zinc finger.

Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation, The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts, ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs, ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1, Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress


This is Probable E3 ubiquitin-protein ligase DTX3 protein, from Mouse, contains 347 amino acids, has 1 RING-type Zinc finger.

RING-type

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context, Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity


This is Rabenosyn-5 protein, from Mouse, contains 783 amino acids, has 1 C2H2-type Zinc finger, has 1 FYVE-type Zinc finger.

FYVE-type

Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes, Required for endosome fusion either homotypically or with clathrin coated vesicles, Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes, Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane, Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3), Plays a role in the recycling of transferrin receptor to the plasma membrane (By similarity)


This is E3 ubiquitin-protein ligase RMND5A protein, from Mouse, contains 391 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1, MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, Catalytic activity of the complex is required for normal cell proliferation, The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1


This is E3 ubiquitin-protein ligase ZNF598 protein, from Mouse, contains 908 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains, ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs, Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation, Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10, Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides, E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3, Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs, Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression


This is Zinc finger protein 618 protein, from Mouse, contains 953 amino acids, has 4 C2H2-type Zinc finger.

Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Amphoterin-induced protein 3 protein, from Rat, contains 508 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May mediate heterophilic cell-cell interaction, May contribute to signal transduction through its intracellular domain

Belongs to the immunoglobulin superfamily, AMIGO family


This is Pre-mRNA-splicing factor SLU7 protein, from Rat, contains 586 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for pre-mRNA splicing as component of the spliceosome, Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron, Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region, May be involved in the activation of proximal AG, Probably also involved in alternative splicing regulation


This is Receptor-transporting protein 2 protein, from Mouse, contains 223 amino acids, has 1 3CxxC-type Zinc finger.

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs


This is Juxtaposed with another zinc finger protein 1 protein, from Mouse, contains 243 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger.

C2H2-type 3; degenerate

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (By similarity), Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (PubMed:24380856), Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (PubMed:24930994), Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (PubMed:24380856, PubMed:25614086), Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (PubMed:25614086, PubMed:24380856)


This is E3 ubiquitin-protein ligase TRIM50 protein, from Rat, contains 483 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1, In turn, promotes starvation-induced autophagy activation, Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction, Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity)