This is E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 protein, from Baker's yeast, contains 274 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:18032921, PubMed:17669696, PubMed:17848550, PubMed:18499666, PubMed:18948542, PubMed:31015336), The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921), The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795), The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440), The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737), During replication, the complex helps to prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698), The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332), It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921), Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336)


This is RNA polymerase II subunit B1 CTD phosphatase RTR1 protein, from Baker's yeast, contains 226 amino acids, has 1 RTR1-type Zinc finger.

RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that dephosphorylates 'Ser-5' of the CTD and regulates RNA polymerase II during the transition from 'Ser-5' to 'Ser-2' phosphorylation


This is Interleukin-6 receptor subunit beta protein, from Human, contains 918 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling, Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168), Also blocks IL11 cluster signaling through IL11R (PubMed:30279168)

Belongs to the type I cytokine receptor family, Type 2 subfamily


This is Interleukin-6 receptor subunit beta protein, from Rat, contains 918 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Signal-transducing molecule, The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission, Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways, That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (By similarity), In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop, Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity), Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity), Has a role in embryonic development (By similarity), Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity), Required for expression of TRPA1 in nociceptive neurons (By similarity), Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity), Required for normal trabecular bone mass and cortical bone composition (By similarity)


This is Carcinoembryonic antigen-related cell adhesion molecule 3 protein, from Human, contains 252 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system, Responsible for RAC1 stimulation in the course of pathogen phagocytosis

Belongs to the immunoglobulin superfamily, CEA family


This is Carcinoembryonic antigen-related cell adhesion molecule 6 protein, from Human, contains 344 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051), Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051), Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051), Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764), Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450), Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051), Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575)


This is T-cell surface protein tactile protein, from Human, contains 585 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response, Promotes NK cell-target adhesion by interacting with PVR present on target cells, May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation


This is Granulocyte colony-stimulating factor receptor protein, from Mouse, contains 837 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Receptor for granulocyte colony-stimulating factor (CSF3), In addition it may function in some adhesion or recognition events at the cell surface


This is B-cell antigen receptor complex-associated protein beta chain protein, from Human, contains 229 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation, Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation


This is B-cell antigen receptor complex-associated protein alpha chain protein, from Bovine, contains 223 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation, Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells, Stimulates SYK autophosphorylation and activation, Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK, Also interacts with and increases activity of some Src-family tyrosine kinases, Represses BCR signaling during development of immature B-cells (By similarity)


This is Vacuolar protein sorting-associated protein 27 protein, from Baker's yeast, contains 622 amino acids, has 1 FYVE-type; atypical Zinc finger.

FYVE-type; atypical

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane (PubMed:3062374, PubMed:1493335, PubMed:9265642, PubMed:11416128, PubMed:12055639, PubMed:11872141, PubMed:12900393, PubMed:14581452, PubMed:15166140, PubMed:15107463, PubMed:15086794, PubMed:17135292, PubMed:18508771), Controls exit from the prevacuolar compartment (PVC) in both the forward direction to the vacuole and the return to the Golgi (PubMed:11208109, PubMed:8649377, PubMed:9015300), Allows VPS10 to return to the (trans-Golgi network) TGN from the PVC (PubMed:8649377), Might also function as an alternate adapter in the COPIb clathrin-like coat (PubMed:17101773)


This is DNA replication licensing factor mcm2 protein, from Fission yeast, contains 830 amino acids, has 1 C4-type Zinc finger.

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity), Plays an important role in DNA replication


This is DNA-directed RNA polymerases I, II, and III subunit RPABC4 protein, from Baker's yeast, contains 70 amino acids, has 1 C4-type Zinc finger.

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively, RNA polymerases are composed of mobile elements that move relative to each other, In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center

Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family


This is Protein FYV10 protein, from Baker's yeast, contains 516 amino acids, has 1 RING-Gid-type Zinc finger.

RING-Gid-type

Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:22044534), Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616, PubMed:22044534), May catalyze ubiquitination of target proteins in complex with RMD5 (Probable), Required for survival upon exposure to K1 killer toxin (PubMed:12663529)


This is Protein AIR1 protein, from Baker's yeast, contains 360 amino acids, has 4 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information, Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met, Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome, AIR1 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1


This is DNA-binding protein SMUBP-2 protein, from Mouse, contains 993 amino acids, has 1 AN1-type; degenerate Zinc finger.

AN1-type; degenerate

5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:22965130, PubMed:8493094), Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:8493094), May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19299493, PubMed:19158098), May play a role in regulation of transcription (By similarity), Interacts with tRNA-Tyr (PubMed:19299493)

Belongs to the DNA2/NAM7 helicase family


This is GTPase-activating protein RacGAP84C protein, from Fruit fly, contains 384 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Involved in the morphogenesis of the adult appendages, GTPase-activating protein for p21-Rac, Promotes the exchange of Rac-bound GDP by GTP


This is Protein GTS1 protein, from Baker's yeast, contains 396 amino acids, has 1 C4-type Zinc finger.

Appears to modulate the timing of budding to obtain an appropriate cell size independent of the DNA replication cycle, Transcription factor involved in both heat resistance and flocculation


This is Histone acetyltransferase SAS2 protein, from Baker's yeast, contains 338 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Histone acetyltransferase (HAT) subunit of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3, The SAS complex is however unable to acetylate nucleosomal histones, The complex is involved in transcriptional silencing at telomeres and at HML locus, Also involved in rDNA silencing and G0 control


This is RNA polymerase I-specific transcription initiation factor RRN7 protein, from Baker's yeast, contains 514 amino acids, has 1 RRN7-type Zinc finger.

Component of RNA polymerase I core factor complex (CF) that acts as a SUA7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription, Binds rDNA promoters and plays a role in Pol I recruitment, After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a pre-initiation complex


This is Zinc finger protein on ecdysone puffs protein, from Fruit fly, contains 716 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

May play a role in the process of early and late gene activation, or possibly in RNA processing, for a defined set of developmentally regulated loci


This is B-cell lymphoma 6 protein protein, from Human, contains 706 amino acids, has 6 C2H2-type Zinc finger.

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions, Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes, Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors, In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155, An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response, In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells, Also required for the establishment and maintenance of immunological memory for both T- and B-cells, Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2, In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners, Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation


This is B-cell lymphoma 6 protein homolog protein, from Mouse, contains 707 amino acids, has 6 C2H2-type Zinc finger.


This is OX-2 membrane glycoprotein protein, from Human, contains 278 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Costimulates T-cell proliferation, May regulate myeloid cell activity in a variety of tissues


This is Hepatocyte nuclear factor 4-alpha protein, from Human, contains 474 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922), Activates the transcription of CYP2C38 (By similarity), Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Eukaryotic translation initiation factor 2 subunit 2 protein, from Fruit fly, contains 312 amino acids, has 1 C4-type Zinc finger.

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA, This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region


This is Protein kinase C iota type protein, from Human, contains 596 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway, Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis, In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step, In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD, Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion, In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival, Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR, This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation, Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity, Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs), In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis, Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Nuclear hormone receptor family member nhr-23 protein, from Caenorhabditis elegans, contains 588 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, Transcription factor (PubMed:9521900, PubMed:21910973, PubMed:11416209, PubMed:35968765), Modulates expression of target genes, such as Period protein homolog lin-42 and microRNA let-7, by binding to hormone response elements (HRE) (PubMed:9521900, PubMed:35968765), Involved in promoting oscillatory expression of the primary transcripts of let-7 and paralogous microRNAs miR-48, miR-84, and miR-241 (PubMed:35968765), Plays a role in normal development and required to regulate each larval molt (PubMed:9521900, PubMed:11416209, PubMed:21910973), Involved in regulating both the frequency and number of molts, acting as part of a negative feedback loop with the let-7 family of microRNAs, perhaps contributing to a self-sustaining molecular-genetic oscillator (PubMed:35968765), Positively modulates expression of collagen and hedgehog-related genes (PubMed:21910973, PubMed:11416209), Involved in development of the gonad and associated epidermal structures (PubMed:11416209, PubMed:9521900), Required in spermatogenesis, acting following the sperm/oocyte cell fate decision, downstream of the canonical sex-determination pathway (PubMed:33060131), Involved in regulating formation of the sperm-specific fibrous body-membranous organelle (FB-MO) complexes, acting independently of transcription regulator spe-44 (PubMed:33060131)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Nuclear hormone receptor family member nhr-6 protein, from Caenorhabditis elegans, contains 619 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator that induces gene expression by binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:20506374), Required for proper morphogenesis of the spermatheca and the spermatheca-uterine valve formation (PubMed:18096150, PubMed:25529479), Promotes cell proliferation and differentiation of the spermatheca precursor cells during spermatheca development in larval stage L4 (PubMed:18096150, PubMed:25529479), Might play a role in promoting G1/S phase progression in the spermatheca precursor cell lineage (PubMed:25529479), Also required for the differentiation of the spermatheca-uterine junction core (sujc) cells which are generating the spermatheca-uterine valve (PubMed:18096150)

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is Steroid hormone receptor family member cnr14 protein, from Caenorhabditis elegans, contains 534 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways (PubMed:21471153, PubMed:23666922, PubMed:16139225, PubMed:17720939, PubMed:33372658), Directly binds to five 5'-A(G/C)(G/T)(T/G)C(A/G)-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development (PubMed:23666922), Together with fox-1 is involved in making the distinction between one and two X-chromosomes (PubMed:21471153, PubMed:23666922, PubMed:33372658), Plays a role in the fox-1-mediated repression of the functionally active isoform (isoform b) of the sex-determining factor xol-1 gene to promote hermaphrodite development (PubMed:33372658), Plays a role in the association of the dosage compensation complex proteins dpy-27 and sdc-3 with the hermaphrodite X chromosomes (PubMed:16139225, PubMed:17720939)


This is Nuclear hormone receptor family member odr-7 protein, from Caenorhabditis elegans, contains 457 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants, Acts in a pathway that specifies olfactory neuronal fate, Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function, Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity

Belongs to the nuclear hormone receptor family, NR0 subfamily


This is T-lymphocyte activation antigen CD86 protein, from Human, contains 329 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

(Microbial infection) Acts as a receptor for adenovirus subgroup B


This is T-lymphocyte activation antigen CD86 protein, from Mouse, contains 309 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4, May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation, Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced, Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (PubMed:23241883)


This is Protein tramtrack, alpha isoform protein, from Fruit fly, contains 813 amino acids, has 2 C2H2-type Zinc finger.

Binds to a number of sites in the transcriptional regulatory region of ftz, Isoform alpha is required to repress genes that promote the R7 cell fate, Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en, May bind to the region 5'-AGGG[CT]GG-3', Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk


This is Longitudinals lacking protein, isoform G protein, from Fruit fly, contains 891 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger.

C2H2-type 1; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is CD166 antigen protein, from Chicken, contains 588 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts, Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity), Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity), Mediates homotypic interactions with cells that express ALCAM (PubMed:1931049, PubMed:22421359), Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction, Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions, Required for normal organization of the lymph vessel network, Required for normal hematopoietic stem cell engraftment in the bone marrow, Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow, Promotes in vitro osteoblast proliferation and differentiation (By similarity), Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (PubMed:1873027, PubMed:22421359), Mediates outgrowth and pathfinding for retinal ganglion cell axons (PubMed:22421359)


This is Formamidopyrimidine-DNA glycosylase protein, from Streptococcus cremoris, contains 273 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG), Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Small ribosomal subunit protein eS27 protein, from Human, contains 84 amino acids, has 1 C4-type Zinc finger.

Component of the small ribosomal subunit (PubMed:8706699, PubMed:23636399), The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399), Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Belongs to the eukaryotic ribosomal protein eS27 family


This is Tyrosine-protein kinase Tec protein, from Human, contains 631 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton, Plays a redundant role to ITK in regulation of the adaptive immune response, Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells, Required for TCR-dependent IL2 gene induction, Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling, Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking, Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein, Required in mast cells for efficient cytokine production, Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells, Participates in platelet signaling downstream of integrin activation, Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription, GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC, TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets, Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway, TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215', May also be involved in the regulation of osteoclast differentiation

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Chaperone protein dnaJ 2 protein, from Mouse-ear cress, contains 419 amino acids, has 1 CR-type Zinc finger.

CR-type

Plays a continuous role in plant development probably in the structural organization of compartments

Belongs to the DnaJ family, A/I subfamily


This is Mitochondrial protein import protein ZIM17 protein, from Baker's yeast, contains 174 amino acids, has 1 DNL-type Zinc finger.

DNL-type

Involved in protein import into mitochondria, Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis, May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix


This is Transcription factor IIIB 70 kDa subunit protein, from Yeast, contains 553 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General activator of RNA polymerase III transcription, Interacts with TBP, Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC


This is Cell surface glycoprotein MUC18 protein, from Human, contains 646 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue, Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread, Could be an adhesion molecule active in neural crest cells during embryonic development, Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration


This is COUP transcription factor 2 protein, from Mouse, contains 414 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro), Regulation of the apolipoprotein A-I gene transcription, Binds to DNA site A, May be required to establish ovary identity during early gonad development


This is Nuclear receptor subfamily 2 group F member 6 protein, from Mouse, contains 390 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor predominantly involved in transcriptional repression, Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors, Involved in modulation of hormonal responses, Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene, Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner, The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6, Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity, Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity, Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC)


This is Matrin-3 protein, from Human, contains 847 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network, In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs, Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728), Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947), May bind to specific miRNA hairpins (PubMed:28431233)


This is Matrin-3 protein, from Rat, contains 845 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network, In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs, Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway, Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs, May bind to specific miRNA hairpins


This is E3 ubiquitin-protein ligase COP1 protein, from Mouse-ear cress, contains 675 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1, Down-regulates MYB21, probably via ubiquitination process, Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm, Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways, Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e,g, hypocotyl growth) (PubMed:26474641), Represses CIP7 in darkness (PubMed:9668129)


This is DNA replication licensing factor MCM7 protein, from Mouse-ear cress, contains 716 amino acids, has 1 C4-type Zinc finger.

Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells (By similarity), Required for megagametophyte and embryo development


This is Early growth response protein 3 protein, from Mouse, contains 387 amino acids, has 3 C2H2-type Zinc finger.

Probable transcription factor involved in muscle spindle development

Belongs to the EGR C2H2-type zinc-finger protein family


This is Interleukin-1 receptor type 2 protein, from Rat, contains 416 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Non-signaling receptor for IL1A, IL1B and IL1RN, Reduces IL1B activities, Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1, Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B, IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN, The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity)

Belongs to the interleukin-1 receptor family


This is Pro-neuregulin-1, membrane-bound isoform protein, from Rat, contains 662 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors, The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart, Binds to ERBB4 and ERBB3, Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4, Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity), Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (PubMed:17250808)


This is Nuclear receptor subfamily 4 group A member 2 protein, from Human, contains 598 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development, It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)


This is Erythroid transcription factor protein, from Rat, contains 413 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development, It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells, Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS


This is Interleukin-12 subunit beta protein, from Mouse, contains 335 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity, IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues, IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines, IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis


This is Mast/stem cell growth factor receptor Kit protein, from Bovine, contains 977 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis, In response to KITLG/SCF binding, KIT can activate several signaling pathways, Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL, Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B, Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Ubiquitin thioesterase OTU1 protein, from Baker's yeast, contains 301 amino acids, has 1 C2H2-type Zinc finger.

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation, Participates in the regulation of the ubiquitin conjugation pathway involving CDC48 by hindering multiubiquitination of substrates at the CDC48 chaperone, May be indirectly involved in PIS1 gene expression


This is N-acetyltransferase ECO1 protein, from Baker's yeast, contains 281 amino acids, has 1 CCHH-type Zinc finger.

CCHH-type

Required for establishment of sister chromatid cohesion during S phase but not for its further maintenance during G2 or M phases or for loading the cohesin complex onto DNA, Interacts with the three known alternate replication factor C (RFC) complexes, suggesting that these complexes have essential but redundant activity in cohesion establishment, Acts by acetylating the cohesin complex component SMC3, In vitro, possesses acetyltransferase activity where it can acetylate itself and components of the cohesin complex (MCD1, IRR1 and PDS5), but is unable to acetylate histones

Belongs to the acetyltransferase family, ECO subfamily


This is Chromatin structure-remodeling complex protein RSC8 protein, from Baker's yeast, contains 557 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is essential for mitotic growth and for repression of CHA1 expression


This is Killer cell immunoglobulin-like receptor 2DL1 protein, from Human, contains 348 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6, Inhibits the activity of NK cells thus preventing cell lysis

Belongs to the immunoglobulin superfamily


This is Killer cell immunoglobulin-like receptor 2DL3 protein, from Human, contains 341 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7), Inhibits the activity of NK cells thus preventing cell lysis


This is Killer cell immunoglobulin-like receptor 3DL1 protein, from Human, contains 444 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for HLA Bw4 allele, Inhibits the activity of NK cells thus preventing cell lysis


This is Killer cell immunoglobulin-like receptor 3DL2 protein, from Human, contains 455 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952), Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270), Acts as a receptor on astrocytes for HLA-F, Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464)


This is Killer cell immunoglobulin-like receptor 2DS2 protein, from Human, contains 304 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer (NK) cells for HLA-C alleles, Does not inhibit the activity of NK cells


This is Killer cell immunoglobulin-like receptor 2DS4 protein, from Human, contains 304 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type


This is Transcription factor GATA-4 protein, from Human, contains 442 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724, PubMed:35182466), In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724), Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression, Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity), Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity), Promotes cardiac myocyte enlargement (PubMed:20081228), Required during testicular development (PubMed:21220346), May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735)


This is Nuclear receptor ROR-beta protein, from Rat, contains 470 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina, Regulates the expression of PTF1A synergistically with FOXN4 (By similarity)


This is Nuclear receptor subfamily 5 group A member 2 protein, from Mouse, contains 560 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis, Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism, Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex, Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver, May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development (By similarity), Activates the transcription of CYP2C38 (PubMed:30555544)

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is Ubiquitin carboxyl-terminal hydrolase 5 protein, from Human, contains 858 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers, Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly, Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity, Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition


This is Krueppel-like factor 1 protein, from Mouse, contains 358 amino acids, has 3 C2H2-type Zinc finger.

Transcription regulator of erythrocyte development, Binds to the CACCC box in the beta-globin gene promoter and activates transcription, Probably serves as a general switch factor for erythroid development, When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Transcription factor GATA-4 protein, from Rat, contains 440 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity), In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity), Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity), Promotes cardiac myocyte enlargement (By similarity), Required during testicular development (By similarity), Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343), Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343), May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity)


This is Transcription factor GATA-6 protein, from Rat, contains 587 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator that regulates SEMA3C and PLXNA2, May regulate genes that protect epithelial cells from bacterial infection, Involved in gene regulation specifically in the gastric epithelium, Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression, Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions


This is Interleukin-12 subunit beta protein, from Bovine, contains 327 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity, IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues, IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines, IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity)


This is Zinc finger protein ZIC 1 protein, from Mouse, contains 447 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Acts as a transcriptional activator, Involved in neurogenesis, Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum, Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN), Plays a role in the regulation of MF axon pathway choice, Promotes MF migration towards ipsilaterally-located cerebellar territories, May have a role in shear flow mechanotransduction in osteocytes, Retains nuclear GLI1 and GLI3 in the cytoplasm, Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'

Belongs to the GLI C2H2-type zinc-finger protein family


This is Zinc-responsive transcriptional regulator ZAP1 protein, from Baker's yeast, contains 880 amino acids, has 6 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Transcription regulator controlling zinc-responsive gene expression, Binds to zinc-responsive elements (ZREs) (consensus sequence 5'-ACCYYNAAGGT-3') in the promoter of target genes (PubMed:9786867), Recruits SWI/SNF, SAGA, and Mediator complexes as coactivators in a zinc-responsive manner (PubMed:22950018), Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation of the zinc uptake system genes ZTR1 and ZTR2 (PubMed:9271382), Positively regulates ETR1 expression, affecting mitochondrial function (PubMed:26711224)


This is Histone demethylase JHD2 protein, from Baker's yeast, contains 728 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code, Demethylates trimethylated H3 'Lys-4'

Belongs to the JARID1 histone demethylase family


This is Rabphilin-3A protein, from Mouse, contains 681 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity), At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity), In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability, Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity)

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane


This is Rabphilin-3A protein, from Rat, contains 684 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Plays an essential role in docking and fusion steps of regulated exocytosis (PubMed:8617225, PubMed:16203731), At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:8617225), In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability (PubMed:26679993), Also plays a role in the exocytosis of arginine vasopressin hormone (PubMed:29367474)


This is mRNA decay activator protein ZFP36 protein, from Rat, contains 320 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:27193233), Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery, Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation, Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, Self regulates by destabilizing its own mRNA (By similarity), Binds to 3'-UTR ARE of numerous mRNAs (PubMed:27193233), Binds also to ARE of its own mRNA, Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages, Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response, Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia, Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs), Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA, Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA, Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs, Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs, May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro, Involved in the delivery of target ARE-mRNAs to processing bodies (PBs), In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing, Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages, Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion, Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis, Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (By similarity)


This is mRNA decay activator protein ZFP36L2 protein, from Human, contains 494 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510, PubMed:34611029), Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868), Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868), Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510), Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868), Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs), Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA, Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA, Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation, In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation, Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA


This is mRNA decay factor CTH2 protein, from Baker's yeast, contains 285 amino acids, has 2 C3H1-type Zinc finger.

Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation, In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways, Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay, Also destabilizes target mRNA by modulating 3'-end processing, creating extended transcripts that are prone for degradation


This is Zinc finger protein zfs1 protein, from Fission yeast, contains 404 amino acids, has 2 C3H1-type Zinc finger.

Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation, Binds to ARE present in the arz1 mRNA and stimulates the rate of arz1 mRNA decay, Required for coordination of septum formation with exit from mitosis, Involved in the mating response pathway, Induces sexual development and ascus formation


This is DNA-directed RNA polymerases I, II, and III subunit RPABC4 protein, from Fission yeast, contains 63 amino acids, has 1 C4-type Zinc finger.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively

Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family


This is Vitamin D3 receptor protein, from Mouse, contains 422 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity), Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity), The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity), Plays a central role in calcium homeostasis (PubMed:32354638), Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638)


This is Retinoic acid receptor RXR-gamma protein, from Human, contains 463 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Transcription initiation factor IIB-1 protein, from Mouse-ear cress, contains 312 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity), Interacts with TBP2 and is required for activated transcription and possibly basal transcription (PubMed:10634912), Plays important roles in pollen tube growth, guidance, and reception as well as endosperm development, Is partially functionally different from TFIIB2 and PBRP2 (PubMed:23547107)


This is Pathogenesis-related homeodomain protein protein, from Mouse-ear cress, contains 796 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Specifically binds to the fungal elicitor-responsive DNA element, 5'-CTAATTGTTTA-3', of the gene PR2 promoter

Belongs to the PHD-associated homeobox family


This is Glucocorticoid receptor protein, from Guinea pig, contains 771 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Nuclear receptor subfamily 2 group C member 2 protein, from Human, contains 596 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor that can act as a repressor or activator of transcription, An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways, May regulate gene expression during the late phase of spermatogenesis, Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, Plays a fundamental role in early embryonic development and embryonic stem cells, Required for normal spermatogenesis and cerebellum development, Appears to be important for neurodevelopmentally regulated behavior (By similarity), Activates transcriptional activity of LHCG, Antagonist of PPARA-mediated transactivation


This is Nuclear receptor subfamily 2 group C member 2 protein, from Mouse, contains 596 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor that can act as a repressor or activator of transcription, An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways, May regulate gene expression during the late phase of spermatogenesis, Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation (By similarity), Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, Plays a fundamental role in early embryonic development and embryonic stem cells, Required for normal spermatogenesis and cerebellum development, Appears to be important for neurodevelopmentally regulated behavior


This is Large ribosomal subunit protein eL37A protein, from Baker's yeast, contains 88 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL37 family


This is Diacylglycerol kinase gamma protein, from Human, contains 791 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity), Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597), Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma, Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity)

Belongs to the eukaryotic diacylglycerol kinase family


This is Diacylglycerol kinase gamma protein, from Rat, contains 788 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:7809169), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity), Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity), Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma, Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity)


This is Diacylglycerol kinase beta protein, from Rat, contains 801 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:7689223, PubMed:23949095), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable), Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (PubMed:7689223), Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity)


This is Hepatocyte nuclear factor 4-alpha protein, from Mouse, contains 474 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity), Activates the transcription of CYP2C38 (PubMed:30555544), Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698)


This is Androgen receptor protein, from Rabbit, contains 709 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation, Transcription activation is also down-regulated by NR0B2, Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3


This is Transcriptional repressor CTCF protein, from Human, contains 727 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 11; atypical Zinc finger.

C2H2-type 11; atypical

Chromatin binding factor that binds to DNA sequence specific sites, Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers, Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene, Also binds to the PLK and PIM1 promoters, Acts as a transcriptional activator of APP, Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression, Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription, Seems to act as tumor suppressor, Plays a critical role in the epigenetic regulation, Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus, On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2, Plays a critical role in gene silencing over considerable distances in the genome, Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones, Inversely, binding to target sites is prevented by CpG methylation, Plays an important role in chromatin remodeling, Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping, Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory, Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription, When bound to chromatin, it provides an anchor point for nucleosomes positioning, Seems to be essential for homologous X-chromosome pairing, May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation, May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation, Involved in sister chromatid cohesion, Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites, Regulates asynchronous replication of IGF2/H19, Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640)

Belongs to the CTCF zinc-finger protein family


This is DNA replication licensing factor Mcm2 protein, from Fruit fly, contains 887 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, Required for the entry in S phase and for cell division


This is DNA replication licensing factor MCM2 protein, from Human, contains 904 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232), The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425), Required for the entry in S phase and for cell division (PubMed:8175912), Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677)


This is Retinoic acid receptor RXR-beta protein, from Rat, contains 458 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)


This is Vacuolar protein sorting-associated protein 41 homolog protein, from Human, contains 854 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways, Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion, The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085, PubMed:33851776), Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847), Required for fusion of autophagosomes with lysosomes (PubMed:25783203), Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847, PubMed:21802320), Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049), Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity), May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660)


This is Glucocorticoid receptor protein, from Rainbow trout, contains 758 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC) (PubMed:7649084, PubMed:8766708), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (By similarity), Affects inflammatory responses, cellular proliferation and differentiation in target tissues (By similarity), Involved in chromatin remodeling (By similarity), Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity), Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity), Mediates glucocorticoid-induced apoptosis (By similarity), Promotes accurate chromosome segregation during mitosis (By similarity), May act as a tumor suppressor (By similarity), May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity)


This is Glucocorticoid receptor protein, from African clawed frog, contains 776 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC) (PubMed:8018720), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (By similarity), Affects inflammatory responses, cellular proliferation and differentiation in target tissues (By similarity), Involved in chromatin remodeling (By similarity), Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity), Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity), Mediates glucocorticoid-induced apoptosis (By similarity), Promotes accurate chromosome segregation during mitosis (By similarity), May act as a tumor suppressor (By similarity), May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity)


This is Transcription factor HNF-4 homolog protein, from Fruit fly, contains 704 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptionally controlled transcription factor, Important for the differentiation of various specialized cell types that arise from both endoderm and mesoderm, May have a role in early gut formation, Plays an essential role in lipid catabolism, regulating lipid mobilization and beta-oxidation in response to nutrient deprivation


This is Ecdysone receptor protein, from Yellowfever mosquito, contains 776 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for ecdysone, Binds to ecdysone response elements (ECRES)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Estrogen receptor protein, from Bovine, contains 596 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP, Can activate the transcriptional activity of TFF1, Also mediates membrane-initiated estrogen signaling involving various kinase cascades, Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity)


This is Estrogen receptor protein, from Sheep, contains 111 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Zinc finger protein 165 protein, from Human, contains 485 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 5 C2H2-type Zinc finger.

C2H2-type 1; degenerate

May be involved in transcriptional regulation


This is Wilms tumor protein homolog protein, from Rat, contains 448 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor that plays an important role in cellular development and cell survival, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3', Regulates the expression of numerous target genes, including EPO, Plays an essential role for development of the urogenital system, It has a tumor suppressor as well as an oncogenic role in tumor formation, Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors, Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing, Isoform 1 has lower affinity for DNA, and can bind RNA

Belongs to the EGR C2H2-type zinc-finger protein family


This is Wilms tumor protein homolog protein, from Stripe-faced dunnart, contains 239 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor that plays an important role in cellular development and cell survival, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3', Regulates the expression of numerous target genes, including EPO, Plays an essential role for development of the urogenital system, It has a tumor suppressor as well as an oncogenic role in tumor formation, Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors, Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing


This is Ubiquitin carboxyl-terminal hydrolase 8 protein, from Baker's yeast, contains 471 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Functions as histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK, SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SLIK is proposed to have partly overlapping functions with SAGA, It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus, Together with SGF11, is required for histone H2B deubiquitination

Belongs to the peptidase C19 family, UBP8 subfamily


This is Estrogen receptor protein, from Japanese rice fish, contains 620 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues


This is Endonuclease 8 protein, from Escherichia coli (strain K12), contains 263 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine, Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is E3 ubiquitin-protein ligase msl-2 protein, from Fruit fly, contains 773 amino acids, has 1 RING-type Zinc finger.

RING-type

The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation), Msl-2 is required for translation and/or stability of msl-1 in males, In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B


This is Steroidogenic factor 1 protein, from Rat, contains 462 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator, Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues, Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B, Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes, 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1, The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity, Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3, Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)


This is E3 ubiquitin-protein ligase RNF19A protein, from Mouse, contains 840 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR

Belongs to the RBR family, RNF19 subfamily


This is E3 ubiquitin-protein ligase RNF144A protein, from Human, contains 292 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC

Belongs to the RBR family, RNF144 subfamily


This is Basal cell adhesion molecule protein, from Human, contains 628 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Laminin alpha-5 receptor, May mediate intracellular signaling


This is Wilms tumor protein homolog protein, from American alligator, contains 288 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor that plays an important role in cellular development and cell survival, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3', Regulates the expression of numerous target genes, Plays an essential role for development of the urogenital system, It has a tumor suppressor as well as an oncogenic role in tumor formation, Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors, Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing


This is Transcriptional regulatory protein PHO23 protein, from Baker's yeast, contains 330 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events


This is Retinoic acid receptor alpha protein, from African clawed frog, contains 458 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity), Required for primary neurogenesis and for anteroposterior neural patterning


This is Retinoic acid receptor RXR-alpha protein, from African clawed frog, contains 488 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for retinoic acid that acts as a transcription factor, Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes, The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription, The high affinity ligand for rxrs is 9-cis retinoic acid, In the absence of ligand, the rar/rxr heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression, On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation