This is Semaphorin-3A protein, from Mouse, contains 772 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Plays a role in growth cones guidance, May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally, Involved in the development of the olfactory system and in neuronal control of puberty (By similarity)


This is Netrin receptor UNC5A protein, from Rat, contains 898 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance (PubMed:9126742, PubMed:10399920), Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1 (PubMed:19755150), Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin (PubMed:10399920), Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion (PubMed:10399920), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206, PubMed:12598531)


This is Netrin receptor UNC5B protein, from Rat, contains 945 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance, Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding, Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (PubMed:10399920, PubMed:9126742), Functions as netrin receptor that negatively regulates vascular branching during angiogenesis, Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206), Mediates apoptosis by activating DAPK1 (PubMed:18582460), In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (PubMed:15729359)


This is Netrin receptor UNC5C protein, from Mouse, contains 931 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance (PubMed:22685302, PubMed:10399920), Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:10399920, PubMed:22685302), NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977), Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (PubMed:10399920), Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (PubMed:22685302), Also involved in corticospinal tract axon guidance independently of DCC (PubMed:9126743, PubMed:9389662, PubMed:12451134), Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity)


This is Ubiquitin-protein ligase E3A protein, from Mouse, contains 870 amino acids, has 1 C4-type; atypical Zinc finger.

C4-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates, Several substrates have been identified including the BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:20211139, PubMed:24728990), Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins, Finally, UBE3A also promotes its own degradation in vivo (By similarity), Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990), Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (PubMed:20211139), Synergizes with WBP2 in enhancing PGR activity (By similarity)


This is Transcription factor COE3 protein, from Mouse, contains 596 amino acids, has 1 C5-type Zinc finger.

Transcriptional activator (PubMed:9151732), Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)


This is Transcription factor COE2 protein, from Mouse, contains 575 amino acids, has 1 C5-type Zinc finger.

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation, Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'


This is Baculoviral IAP repeat-containing protein 3 protein, from Mouse, contains 600 amino acids, has 1 RING-type Zinc finger.

RING-type

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis, Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling, The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10, Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs), Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner, Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8


This is Krueppel-like factor 10 protein, from Rat, contains 480 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3', Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver, Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis, May play a role in the cell cycle regulation (By similarity), Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Zinc finger protein Aiolos protein, from Mouse, contains 507 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 4; atypical

C2H2-type 6; atypical

Transcription factor that plays an important role in the regulation of lymphocyte differentiation, Binds to GGGAA, Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state, Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Zinc finger protein SNAI2 protein, from Rat, contains 268 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; atypical Zinc finger.

C2H2-type 5; atypical

Transcriptional repressor that modulates both activator-dependent and basal transcription, Involved in the generation and migration of neural crest cells, Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells, Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells, In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription, Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes, Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes, Represses E-Cadherin/CDH1 transcription via E-box elements, Involved in osteoblast maturation, Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts, Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts, Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity)

Belongs to the snail C2H2-type zinc-finger protein family


This is Nuclear receptor subfamily 2 group F member 6 protein, from Rat, contains 390 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor predominantly involved in transcriptional repression, Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors, Involved in modulation of hormonal responses, Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene, Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner, The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6, Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity, Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity, Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC) (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is COUP transcription factor 2 protein, from Rat, contains 414 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro), Regulation of the apolipoprotein A-I gene transcription, Binds to DNA site A, May be required to establish ovary identity during early gonad development


This is Endothelial transcription factor GATA-2 protein, from Mouse, contains 480 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells, Binds to the consensus sequence 5'-AGATAG-3'


This is Semaphorin-4D protein, from Mouse, contains 861 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (By similarity), Regulates GABAergic synapse development (PubMed:23699507, PubMed:29981480), Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (PubMed:23699507, PubMed:29981480), Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity), Promotes the migration of cerebellar granule cells (PubMed:17554007), Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (By similarity), Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (By similarity)


This is Gag polyprotein protein, from HIV-1, contains 496 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Estrogen receptor beta protein, from Japanese eel, contains 573 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is V(D)J recombination-activating protein 2 protein, from Zebrafish, contains 530 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical

Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination, V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments, DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends, In the RAG complex, rag2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1, It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity)


This is Glucocorticoid receptor protein, from Bolivian squirrel monkey, contains 777 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression


This is DNA replication fork-blocking protein FOB1 protein, from Baker's yeast, contains 566 amino acids, has 1 C2H2-type Zinc finger.

Required for replication fork blocking activity at the replication fork barrier (RFB) site in rDNA and for recombination hot-spot (HOT1) activity, regulating the recombination rate and the number of rDNA copies, Binds directly to two separated sequences in the RFB


This is Ribosomal protein arginine N-methyltransferase rmt3 protein, from Fission yeast, contains 543 amino acids, has 1 C2H2-type Zinc finger.

Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in ribosomal protein rps2

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family


This is Uncharacterized ATP-dependent helicase C17A2.12 protein, from Fission yeast, contains 897 amino acids, has 1 RING-type Zinc finger.

RING-type

Belongs to the SNF2/RAD54 helicase family


This is SWI/SNF and RSC complexes subunit ssr1 protein, from Fission yeast, contains 527 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, Controls particularly membrane and organelle development genes, Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors


This is RNA-binding protein involved in heterochromatin assembly dri1 protein, from Fission yeast, contains 604 amino acids, has 3 RanBP2-type Zinc finger.

Mediates heterochromatin assembly by promoting RNAi-mediated heterochromatin silencing and histone deacetylation (PubMed:33693625), Binds pericetromeric transcripts and recruits the RNA-induced transcriptional silencing (RITS) complex to heterochromatin (PubMed:33693625), Recruits sir2 to chromatin to promote deacetylation of 'Lys-9' of histone H3 (PubMed:33693625)


This is Vacuolar protein sorting-associated protein 27 protein, from Fission yeast, contains 610 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane


This is E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1 protein, from Fission yeast, contains 254 amino acids, has 1 RING-type Zinc finger.

RING-type

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains, Involved in maintaining genome stability where it acts in the cellular response to DNA damage, Has a role in meiosis


This is RING-box protein pip1 protein, from Fission yeast, contains 107 amino acids, has 1 RING-type Zinc finger.

RING-type

Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, Seems to recruit the E2 ubiquitination enzyme, like UBC3/CDC34, to the complex and brings it into close proximity to the substrate, Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation, H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci


This is Probable Rho-type GTPase-activating protein 3 protein, from Fission yeast, contains 969 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

GTPase-activating protein for Rho-type proteins


This is ER-phagy receptor 1 protein, from Fission yeast, contains 380 amino acids, has 1 C2H2-type Zinc finger.

Reticulophagy receptor required for autophagosomal sequestration of endoplasmic reticulum (ER) membranes during ER stress (Ref,5), Confers resistance to ER stress by promoting the autophagic degradation of the ER (ER-phagy or reticulophagy) (Ref,5), Acts as a bridging molecule to mediate the association between atg8 on the autophagic membrane and the vesicle-associated membrane protein-associated proteins (VAPs) scs2 and scs22 on the ER (Ref,5), May play a role in meiosis (PubMed:16303567)


This is SWI/SNF and RSC complexes subunit ssr2 protein, from Fission yeast, contains 503 amino acids, has 1 ZZ-type; degenerate Zinc finger.

ZZ-type; degenerate


This is Pro-neuregulin-2, membrane-bound isoform protein, from Human, contains 850 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors, May also promote the heterodimerization with the EGF receptor


This is Zinc finger protein 195 protein, from Human, contains 629 amino acids, has 9 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein 213 protein, from Human, contains 459 amino acids, has 5 C2H2-type Zinc finger.


This is Krueppel-like factor 11 protein, from Human, contains 512 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor (PubMed:9748269, PubMed:10207080), Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492), Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity), Induces apoptosis (By similarity)


This is Natural cytotoxicity triggering receptor 3 protein, from Human, contains 201 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1, Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands, It controls, for instance, NK cells cytotoxicity against tumor cells, Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation

Belongs to the natural cytotoxicity receptor (NCR) family


This is Hepatocyte growth factor-regulated tyrosine kinase substrate protein, from Human, contains 777 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Involved in intracellular signal transduction mediated by cytokines and growth factors, When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF, Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin, May concentrate ubiquitinated receptors within clathrin-coated regions, Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex), The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes, May contribute to the efficient recruitment of SMADs to the activin receptor complex, Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation


This is Zinc finger protein 263 protein, from Human, contains 683 amino acids, has 9 C2H2-type Zinc finger.

Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553), Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553), Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030)


This is Semaphorin-3E protein, from Human, contains 775 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Plays an important role in signaling via the cell surface receptor PLXND1, Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections, Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix, Regulates angiogenesis, both during embryogenesis and after birth, Can down-regulate sprouting angiogenesis, Required for normal vascular patterning during embryogenesis, Plays an important role in ensuring the specificity of synapse formation (By similarity)


This is Zinc finger and BTB domain-containing protein 39 protein, from Human, contains 712 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 8; atypical Zinc finger.

C2H2-type 2; atypical

C2H2-type 3; atypical

C2H2-type 8; atypical


This is Zinc finger and BTB domain-containing protein 5 protein, from Human, contains 677 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical


This is Muscle, skeletal receptor tyrosine-protein kinase protein, from Human, contains 869 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362), Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May positively regulate Rho family GTPases through FNTA, Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is Protein Mdm4 protein, from Human, contains 490 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

Along with MDM2, contributes to TP53 regulation (PubMed:32300648), Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Inhibits degradation of MDM2, Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions


This is Zinc finger and BTB domain-containing protein 7B protein, from Human, contains 539 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors, Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner, Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment, Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively, Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision, Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling, induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate, During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci, Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells, Also functions as an important metabolic regulator in the lactating mammary glands, Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity), Transcriptional repressor of the collagen COL1A1 and COL1A2 genes, May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309), Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation, Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity)


This is Zinc finger and BTB domain-containing protein 22 protein, from Human, contains 634 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 2 C2H2-type Zinc finger.

C2H2-type 1; atypical


This is E3 ubiquitin-protein ligase Midline-1 protein, from Human, contains 667 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination


This is Sialic acid-binding Ig-like lectin 5 protein, from Human, contains 551 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is Transcription factor YY2 protein, from Human, contains 372 amino acids, has 4 C2H2-type Zinc finger.

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes, May antagonize YY1 and function in development and differentiation

Belongs to the YY transcription factor family


This is Neural cell adhesion molecule 2 protein, from Human, contains 837 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons


This is Forkhead box protein P2 protein, from Human, contains 715 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium, May also play a role in developing neural, gastrointestinal and cardiovascular tissues, Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential, Plays a role in synapse formation by regulating SRPX2 levels, Involved in neural mechanisms mediating the development of speech and language


This is Nucleoporin NUP42 protein, from Human, contains 423 amino acids, has 1 C3H1-type Zinc finger.

(Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope


This is Tapasin protein, from Human, contains 448 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)


This is Zinc finger and SCAN domain-containing protein 9 protein, from Human, contains 394 amino acids, has 5 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase RNF113A protein, from Human, contains 343 amino acids, has 1 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

Required for pre-mRNA splicing as component of the spliceosome (PubMed:29361316, PubMed:29360106), As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable), E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457), Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457), Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457), Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524)


This is Pyrin protein, from Human, contains 781 amino acids, has 1 B box-type Zinc finger.

B box-type

Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:16037825, PubMed:27030597, PubMed:28835462, PubMed:16785446, PubMed:17431422, PubMed:26347139), Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139), Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139), However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462), Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity), It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923), Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923)


This is Protein muscleblind protein, from Fruit fly, contains 297 amino acids, has 2 C3H1-type Zinc finger.

Required for terminal differentiation of photoreceptor cells, Vital for embryonic development


This is Chromodomain-helicase-DNA-binding protein 3 protein, from Fruit fly, contains 892 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Helicase which acts in nucleosome-remodeling by catalyzing ATP-dependent nucleosome mobilization (PubMed:18250149), Likely to be involved in the regulation of transcription (PubMed:18250149)


This is Interleukin-6 receptor subunit alpha protein, from Pig, contains 467 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (By similarity), The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling', sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases, In complex with IL6, is required for induction of VEGF production (By similarity), Plays a protective role during liver injury, being required for maintenance of tissue regeneration, 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity)

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Peroxisome proliferator-activated receptor gamma protein, from Rhesus macaque, contains 505 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase, It therefore controls the peroxisomal beta-oxidation pathway of fatty acids, Key regulator of adipocyte differentiation and glucose homeostasis, ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer, Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses, Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Peroxisome proliferator-activated receptor gamma protein, from Bovine, contains 505 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Rab5 GDP/GTP exchange factor protein, from Bovine, contains 492 amino acids, has 1 A20-type Zinc finger.

Rab effector protein acting as linker between gamma-adaptin and RAB5A, Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes, Stimulates nucleotide exchange on RAB5A, Can act as a ubiquitin ligase


This is Cyclin-dependent kinase inhibitor 1 protein, from Cat, contains 164 amino acids, has 1 C4-type Zinc finger.

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity), Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity), Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity), At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity), Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity), Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity)


This is Peroxisome proliferator-activated receptor gamma protein, from Rabbit, contains 475 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type


This is Protein kinase C zeta type protein, from Rabbit, contains 591 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP), Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation, Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator, Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes, In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C, Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6, Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors, In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein, In association with FEZ1, stimulates neuronal differentiation in PC12 cells, In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6, May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response, In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311', Phosphorylates VAMP2 in vitro (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Major histocompatibility complex class I-related gene protein protein, from Rat, contains 343 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells, In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity), Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis, Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity), May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin, Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity), During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity), Acts as an immune sensor of cancer cell metabolome, May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity)


This is Axial regulator YABBY 1 protein, from Mouse-ear cress, contains 229 amino acids, has 1 C4-type Zinc finger.

Involved in the abaxial cell fate determination during embryogenesis and organogenesis, Regulates the initiation of embryonic shoot apical meristem (SAM) development (PubMed:10323860, PubMed:10331982, PubMed:10457020, PubMed:11812777, PubMed:12417699, PubMed:9878633, Ref,3, Ref,6, PubMed:19837869), Required during flower formation and development, particularly for the patterning of floral organs, Positive regulator of class B (AP3 and PI) activity in whorls 2 and 3, Negative regulator of class B activity in whorl 1 and of SUP activity in whorl 3, Interacts with class A proteins (AP1, AP2 and LUG) to repress class C (AG) activity in whorls 1 and 2, Contributes to the repression of KNOX genes (STM, KNAT1/BP and KNAT2) to avoid ectopic meristems, Binds DNA without sequence specificity, In vitro, can compete and displace the AP1 protein binding to DNA containing CArG box (PubMed:10323860, PubMed:10331982, PubMed:10457020, PubMed:11812777, PubMed:12417699, PubMed:9878633, Ref,3, Ref,6)


This is Probable E3 ubiquitin-protein ligase RHC1A protein, from Mouse-ear cress, contains 328 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro


This is Glycine-rich RNA-binding protein RZ1B protein, from Mouse-ear cress, contains 292 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Binds RNA and DNA sequences non-specifically, May be involved in tolerance to cold stress


This is Probable E3 ubiquitin-protein ligase ATL44 protein, from Mouse-ear cress, contains 185 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that possess E3 ubiquitin ligase activity in vitro and mediates protein monoubiquitination (Ref,7), Triggers the monoubiquitination of phosphorylated BIK1 in response to pathogen-associated molecular pattern (PAMP) detection (Ref,7)

Belongs to the RING-type zinc finger family, ATL subfamily


This is Histone deacetylase HDT1 protein, from Maize, contains 307 amino acids, has 1 C2H2-type; degenerate Zinc finger.

C2H2-type; degenerate

Mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Able to deacetylate all 4 core histones

Belongs to the histone deacetylase HD2 family


This is Formamidopyrimidine-DNA glycosylase protein, from Bacillus subtilis (strain 168), contains 276 amino acids, has 1 FPG-type Zinc finger.

FPG-type

Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool, 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A,T to G,C transversions (By similarity), Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Acts as DNA glycosylase that recognizes and removes damaged bases, Has a preference for oxidized purines, such as 8-oxo-dGTP, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base


This is CD166 antigen protein, from Rat, contains 583 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts, Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity), Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity), Mediates homotypic interactions with cells that express ALCAM, Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction, Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions, Required for normal organization of the lymph vessel network, Required for normal hematopoietic stem cell engraftment in the bone marrow, Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow, Promotes in vitro osteoblast proliferation and differentiation (By similarity), Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity), Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)


This is Four and a half LIM domains protein 2 protein, from Rat, contains 279 amino acids, has 1 C4-type Zinc finger.

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation, Negatively regulates the transcriptional repressor E4F1 and may function in cell growth, Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity), Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:22851699)


This is Neural cell adhesion molecule 2 protein, from Mouse, contains 837 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons


This is E3 ubiquitin-protein ligase RNF5 protein, from Mouse, contains 180 amino acids, has 1 RING-type Zinc finger.

RING-type

Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:23093945), May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (By similarity), Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (By similarity), Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (By similarity), Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (By similarity), Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945)


This is Peroxisome proliferator-activated receptor alpha protein, from Guinea pig, contains 467 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Ligand-activated transcription factor, Key regulator of lipid metabolism, Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC), Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety, Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the ACOX1 and P450 genes, Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2, May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity)


This is Pro-neuregulin-2, membrane-bound isoform protein, from Rat, contains 868 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors, May also promote the heterodimerization with the EGF receptor


This is Zinc finger protein ZFPM1 protein, from Mouse, contains 995 amino acids, has 5 CCHC FOG-type Zinc finger, has 4 C2H2-type Zinc finger.

CCHC FOG-type

CCHC FOG-type

CCHC FOG-type

CCHC FOG-type

CCHC FOG-type

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation, Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3, Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context, The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1, May be involved in regulation of some genes in gonads, May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2

Belongs to the FOG (Friend of GATA) family


This is Protein Mdm4 protein, from Mouse, contains 489 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Inhibits degradation of MDM2, Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions, The short isoform is a more potent inhibitor of TP53 activity than the long isoform


This is Nuclear receptor subfamily 1 group I member 3 protein, from Mouse, contains 358 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes, Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity)


This is E3 ubiquitin-protein ligase RING1 protein, from Mouse, contains 406 amino acids, has 1 RING-type Zinc finger.

RING-type

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation, H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility, Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity)


This is Krueppel-like factor 12 protein, from Mouse, contains 402 amino acids, has 3 C2H2-type Zinc finger.

Confers strong transcriptional repression to the AP-2-alpha gene, Binds to a regulatory element (A32) in the AP-2-alpha gene promoter

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Krueppel-like factor 9 protein, from Mouse, contains 244 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds to GC box promoter elements, Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box, Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation


This is Hereditary hemochromatosis protein homolog protein, from Rat, contains 360 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin


This is Krueppel-like factor 6 protein, from Rat, contains 283 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional activator, Binds a GC box motif, Could play a role in B-cell growth and development (By similarity)


This is Zinc finger protein basonuclin-1 protein, from Mouse, contains 961 amino acids, has 6 C2H2-type Zinc finger.

Transcriptional activator (PubMed:9687312, PubMed:23707421), It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (By similarity), Required for the maintenance of spermatogenesis (PubMed:22266914), It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (By similarity), May also play a role in the early development of embryos (PubMed:9687312)


This is E3 ubiquitin-protein ligase MIR1 protein, from MuHV-4, contains 201 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the endoplasmic reticulum-associated degradation (ERAD) system, thus blocking the immune detection of virus-infected cells, Mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules, Promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage


This is E3 ubiquitin-protein ligase Mdm2 protein, from Zebrafish, contains 445 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome


This is Vitamin D3 receptor protein, from Chicken, contains 451 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells, Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR, The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity), Plays a central role in calcium homeostasis (By similarity), Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)


This is DNA-binding protein Ikaros protein, from Chicken, contains 518 amino acids, has 6 C2H2-type Zinc finger.

Binds and activates the enhancer (delta-A element) of the CD3-delta gene, Functions in the specification and the maturation of the T-lymphocyte, Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development, Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is N-acetyltransferase eso1 protein, from Fission yeast, contains 872 amino acids, has 1 UBZ3-type Zinc finger, has 1 CCHH-type Zinc finger.

CCHH-type

Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together, In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase, The relevance of acetyltransferase function remains unclear (By similarity)

In the N-terminal section; belongs to the DNA polymerase type-Y family


This is DSC E3 ubiquitin ligase complex subunit 1 protein, from Fission yeast, contains 695 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions, The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation


This is E3 ubiquitin-protein ligase Praja-2 protein, from Human, contains 708 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175), Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation, Essential for PKA-mediated long-term memory processes (PubMed:21423175), Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450), Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390)


This is Zinc finger and BTB domain-containing protein 24 protein, from Human, contains 697 amino acids, has 8 C2H2-type Zinc finger.

May be involved in BMP2-induced transcription


This is PHD finger protein 1 protein, from Human, contains 567 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, Involved in DNA damage response and is recruited at double-strand breaks (DSBs), Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex, According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982), According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980), Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53


This is E3 ubiquitin-protein ligase SIAH2 protein, from Human, contains 324 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9334332, PubMed:11483518, PubMed:19224863), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9334332, PubMed:11483518, PubMed:19224863), Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:9334332, PubMed:11483518, PubMed:19224863), Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:9334332, PubMed:11483518, PubMed:19224863), Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263), It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:9334332, PubMed:11483518, PubMed:19224863, PubMed:22878263), Has some overlapping function with SIAH1 (PubMed:9334332, PubMed:11483518, PubMed:19224863), Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493), Promotes monoubiquitination of SNCA (PubMed:19224863), Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558), Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558), Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity), Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1

Belongs to the SINA (Seven in absentia) family


This is Zinc finger HIT domain-containing protein 1 protein, from Human, contains 154 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A,Z into the genome to regulate gene expression (PubMed:20473270, PubMed:35175558), Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (By similarity), Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone H2AZ1 to chromatin and induces muscle-specific gene expression (PubMed:20473270), Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (By similarity), Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (By similarity), Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (By similarity), Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (By similarity), Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (By similarity), During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (By similarity), In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (PubMed:35175558), Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (PubMed:17380123), Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (PubMed:17700068), Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (By similarity), Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (By similarity), Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (PubMed:17892483)


This is Zinc finger protein 264 protein, from Human, contains 627 amino acids, has 13 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Zinc finger and BTB domain-containing protein 43 protein, from Human, contains 467 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger.

C2H2-type 1; atypical

C2H2-type 3; atypical


This is Zinc finger and SCAN domain-containing protein 12 protein, from Human, contains 611 amino acids, has 12 C2H2-type Zinc finger.


This is ATM interactor protein, from Human, contains 823 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

Transcription factor, Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage, Involved in regulating the activity of ATM in the absence of DNA damage, May play a role in stabilizing ATM, Binds to the DYNLL1 promoter and activates its transcription


This is Ras GTPase-activating protein 4 protein, from Human, contains 803 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium, Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis


This is 52 kDa repressor of the inhibitor of the protein kinase protein, from Human, contains 761 amino acids, has 1 THAP-type Zinc finger.

THAP-type

Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR), May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth


This is Protein CBFA2T2 protein, from Human, contains 604 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199), Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218), Involved in primordial germ cell (PCG) formation, Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity), Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453), May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21), May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth, May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region, Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity), Required for the maintenance of the secretory cell lineage in the small intestine, Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity)


This is Krueppel-like factor 4 protein, from Human, contains 513 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor; can act both as activator and as repressor, Binds the 5'-CACCC-3' core sequence, Binds to the promoter region of its own gene and can activate its own transcription, Regulates the expression of key transcription factors during embryonic development, Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation, Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface, Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development, Contributes to the down-regulation of p53/TP53 transcription


This is E3 ubiquitin-protein ligase RNF13 protein, from Human, contains 381 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371), Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371), Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371), Also involved in protein trafficking and localization (PubMed:24387786)


This is Zinc finger protein SNAI2 protein, from Human, contains 268 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; atypical Zinc finger.

C2H2-type 5; atypical

Transcriptional repressor that modulates both activator-dependent and basal transcription, Involved in the generation and migration of neural crest cells, Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity), Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells, In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription, Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes, Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes, Represses E-Cadherin/CDH1 transcription via E-box elements, Involved in osteoblast maturation, Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts, Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts, Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis

Belongs to the snail C2H2-type zinc-finger protein family


This is BUB3-interacting and GLEBS motif-containing protein ZNF207 protein, from Human, contains 478 amino acids, has 2 C2H2-type Zinc finger.

Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440), ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets, Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440), Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187), Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186), According to another report, the stabilization is independent of the proteasome (PubMed:24462187)


This is Sialic acid-binding Ig-like lectin 6 protein, from Human, contains 453 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule that mediates sialic-acid dependent binding to cells, Binds to alpha-2,6-linked sialic acid, The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface


This is A-kinase anchor protein 8 protein, from Human, contains 692 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338), Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis, Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380), May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107), Required for cell cycle G2/M transition and histone deacetylation during mitosis, In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585), Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794), May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381), Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation, In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757), May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597), May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274), May play a repressive role in the regulation of rDNA transcription, Preferentially binds GC-rich DNA in vitro, In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827), Involved in modulation of Toll-like receptor signaling, Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity)


This is Zinc finger and BTB domain-containing protein 14 protein, from Human, contains 449 amino acids, has 5 C2H2-type Zinc finger.

Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3', Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene, Transcriptional repressor of MYC and thymidine kinase promoters


This is Autoimmune regulator protein, from Human, contains 545 amino acids, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028), Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box, Binds to nucleosomes (By similarity), Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2', Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression, Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028), Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program, Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression, Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes, In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection, In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells, Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity)


This is Nuclear hormone receptor family member nhr-49 protein, from Caenorhabditis elegans, contains 501 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor (PubMed:25981666), Regulates expression of genes involved in fat metabolism and in maintaining homeostasis of fatty acid saturation, such as lipid desaturase fat-7, and acyl-CoA synthetase acs-2 (PubMed:25981666, PubMed:15719061, PubMed:22511885), May form part of a negative feedback loop with fat-7 to limit mitochondrial beta-oxidation, in which it stimulates expression of fat-7 and acs-2, and in turn fat-7 indirectly inhibits acs-2 and other genes also involved in beta-oxidation (PubMed:15719061), As part of a lysosome-to-nucleus retrograde lipid signaling pathway, acting in concert with nuclear hormone receptor nhr-80, activates the transcription of genes promoting longevity and mitochondrial beta-oxidation (PubMed:25554789, PubMed:26671266), In concert with nuclear hormone receptor nhr-66, involved in regulating target genes with roles in sphingolipid breakdown and lipid remodeling (PubMed:22511885), Also involved in regulating fatty acid desaturase genes, acting in concert with nuclear hormone receptors nhr-13 and nhr-80 (PubMed:22511885), Plays a role in modulating mitochondrial morphology and function (PubMed:22511885), Plays a role in transgenerational lipid accumulation in response to a high-fat diet (PubMed:35140229)

Belongs to the nuclear hormone receptor family


This is Regulation of longevity by E3 ubiquitin-protein ligase protein, from Caenorhabditis elegans, contains 952 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

E3 ubiquitin-protein ligase, Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance (PubMed:17276341), Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic bacterial infection (PubMed:24448648)


This is Splicing factor 3A subunit 3 protein, from Fruit fly, contains 503 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity), Involved in male fertility


This is Glucocorticoid receptor protein, from Common squirrel monkey, contains 778 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC) (PubMed:10775802, PubMed:11703081), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:10775802, PubMed:11703081, PubMed:15857751), Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling (By similarity), Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity), Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity), Mediates glucocorticoid-induced apoptosis (By similarity), Promotes accurate chromosome segregation during mitosis (By similarity), May act as a tumor suppressor (By similarity), May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity)

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Tyrosine-protein phosphatase non-receptor type substrate 1 protein, from Bovine, contains 506 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C1-type Immunoglobulin domain.

Ig-like V-type

Ig-like C1-type

Ig-like C1-type

Immunoglobulin-like cell surface receptor for CD47, Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane, Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, May play a key role in intracellular signaling during synaptogenesis and in synaptic function, Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin, Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation, CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells, Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity), Receptor for THBS1 (By similarity), Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity), In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (By similarity)


This is E3 ubiquitin-protein ligase MBR2 protein, from Mouse-ear cress, contains 666 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that functions as regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way, Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering, May function downstream of HAL3 and be required for HAL3-regulated plant growth, Activation of MBR2 by HAL3 may lead to the degradation of cell cycle suppressors, resulting in enhancement of cell division and plant growth

Belongs to the RING-type zinc finger family


This is Zinc finger protein CONSTANS-LIKE 1 protein, from Mouse-ear cress, contains 355 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger.

B box-type 1; atypical

B box-type 2; atypical

Putative transcription factor that may be involved in the light input to the circadian clock but does not affect flowering time


This is E3 SUMO-protein ligase PIAS3 protein, from Mouse, contains 628 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway, Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth, Repressor of MITF transcriptional activity, Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation, Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity), Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity)


This is Rab effector Noc2 protein, from Rat, contains 302 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells, Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A, Acts as a potential RAB3B effector protein in epithelial cells


This is OX-2 membrane glycoprotein protein, from Mouse, contains 278 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Costimulates T-cell proliferation, May regulate myeloid cell activity in a variety of tissues (By similarity)


This is Nuclear receptor subfamily 1 group I member 2 protein, from Mouse, contains 431 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds, Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs, Response to specific ligands is species-specific, due to differences in the ligand-binding domain, Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity), Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN)


This is Hepatitis A virus cellular receptor 1 homolog protein, from Rat, contains 307 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity), As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses, Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity), Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10, Acts as regulator of T-cell proliferation (By similarity), May play a role in kidney injury and repair (By similarity)

Belongs to the immunoglobulin superfamily, TIM family


This is E3 ubiquitin-protein ligase RNF13 protein, from Mouse, contains 381 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:19292867), Involved in apoptosis regulation (By similarity), Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity), Also involved in protein trafficking and localization (By similarity)


This is Protein CBFA2T3 protein, from Mouse, contains 620 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes, Can repress the expression of MMP7 in a ZBTB33-dependent manner, Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway, Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (By similarity), Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:16407974), Plays a role in granulocyte differentiation (PubMed:15231665)


This is Serine/threonine-protein phosphatase 1 regulatory subunit 10 protein, from Rat, contains 872 amino acids, has 1 C3H1-type Zinc finger.

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex, The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase, Mediates interaction of WDR82 and PPP1CA, Inhibitor of PPP1CA and PPP1CC phosphatase activities, Has inhibitory activity on PPP1CA only when phosphorylated, Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers


This is E3 ubiquitin-protein ligase Praja-1 protein, from Mouse, contains 578 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E2-dependent E3 ubiquitin-protein ligase activity, Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome, May be involved in protein sorting


This is Zinc finger protein ZIC 3 protein, from African clawed frog, contains 441 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Probably acts as a transcriptional activator, May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3', Can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development, Involved in establishing left-right asymmetry in the embryo

Belongs to the GLI C2H2-type zinc-finger protein family


This is Hsk1-interacting molecule 1 protein, from Fission yeast, contains 545 amino acids, has 1 DBF4-type Zinc finger.

Activates hsk1 kinase and is essential for G1/S transition, Has a role in S-phase checkpoint control induced by replication fork blocks after nucleotide deprivation and DNA damage


This is Set1 complex component ash2 protein, from Fission yeast, contains 652 amino acids, has 1 PHD-type Zinc finger.

PHD-type

The Set1 complex specifically methylates 'Lys-4' of histone H3


This is E3 ubiquitin-protein ligase parkin protein, from Human, contains 465 amino acids, has 1 RING-type 0; atypical Zinc finger, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type 0; atypical

RING-type

IBR-type

RING-type 2; atypical

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:32047033, PubMed:29311685, PubMed:22396657), Substrates include SYT11 and VDAC1 (PubMed:32047033, PubMed:29311685), Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:22396657), Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951, PubMed:32047033, PubMed:25474007), Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105), Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:19229105, PubMed:15728840), Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974), Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:32047033, PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:18957282, PubMed:21376232, PubMed:22396657, PubMed:24660806, PubMed:25474007, PubMed:24784582, PubMed:11439185, PubMed:22082830, PubMed:23933751), Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:32047033, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:21376232, PubMed:22396657, PubMed:11439185, PubMed:22082830, PubMed:23933751, PubMed:33499712), Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:25474007, PubMed:24784582, PubMed:25527291), After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033), When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:22396657, PubMed:23933751), Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033), The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051), This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051), Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657), Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232), Limits the production of reactive oxygen species (ROS) (PubMed:18541373), Regulates cyclin-E during neuronal apoptosis (PubMed:12628165), In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830), Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972), May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185), May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis, May represent a tumor suppressor gene (PubMed:12719539)

Belongs to the RBR family, Parkin subfamily


This is E3 ubiquitin-protein ligase MGRN1 protein, from Human, contains 552 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H, Plays a role in the regulation of endosome-to-lysosome trafficking, Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production, Does not inhibit ADRB2-signaling, Does not promote MC1R ubiquitination, Acts also as a negative regulator of hedgehog signaling (By similarity)


This is Zinc finger protein 500 protein, from Human, contains 480 amino acids, has 5 C2H2-type Zinc finger.

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family