This is Nuclear receptor subfamily 4 group A member 3 protein, from Rat, contains 628 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner (PubMed:7811288), Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (PubMed:10523643), Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation, Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity), Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression (PubMed:16945922), In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (PubMed:24706823), Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner, During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity), Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance, Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation, Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity), Also plays a role in inflammation; Upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity), In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation, Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP-glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1, Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity), Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (By similarity), Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration (By similarity), Also participates in cardiac hypertrophy by activating PARP1 (PubMed:25625556)

Belongs to the nuclear hormone receptor family, NR4 subfamily


This is Large ribosomal subunit protein eL37B protein, from Baker's yeast, contains 88 amino acids, has 1 C4-type Zinc finger.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL37 family


This is Nuclear receptor ROR-alpha protein, from Mouse, contains 523 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence, Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism, Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively, Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts, Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1, Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction, Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1, Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression, Therefore influences the period length and stability of the clock, Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG, In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1, Induces a rhythmic expression of some of these genes, In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism, Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1, In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms, May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding, Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program, Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus, Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A, May inhibit cell growth in response to cellular stress, May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Nuclear receptor ROR-gamma protein, from Human, contains 518 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches, Required for the generation of LTi (lymphoid tissue inducer) cells, Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2, Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program, Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus, May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus


This is Nuclear receptor ROR-gamma protein, from Mouse, contains 516 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches (PubMed:10602018, PubMed:14691482, PubMed:16148126), Required for the generation of LTi (lymphoid tissue inducer) cells, Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2, Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program, Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus (PubMed:16990136, PubMed:18164222, PubMed:26607793), May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus (PubMed:9881970, PubMed:10602018, PubMed:14691482, PubMed:16148126, PubMed:16990136, PubMed:18164222), Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (By similarity)


This is Gag polyprotein protein, from Simian retrovirus SRV-2, contains 654 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag-Pro polyprotein protein, from Simian retrovirus SRV-2, contains 908 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Enhances the activity of the reverse transcriptase, May be part of the mature RT


This is Diacylglycerol kinase alpha protein, from Rat, contains 727 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:22627129), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:22627129), Also plays an important role in the biosynthesis of complex lipids, Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (By similarity), Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129)

Belongs to the eukaryotic diacylglycerol kinase family


This is Nuclear receptor subfamily 4 group A member 1 protein, from Dog, contains 598 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor, May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration, Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3', May inhibit NF-kappa-B transactivation of IL2, Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity)


This is E3 SUMO-protein ligase EGR2 protein, from Rat, contains 470 amino acids, has 3 C2H2-type Zinc finger.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity

Belongs to the EGR C2H2-type zinc-finger protein family


This is Cytoplasmic tyrosine-protein kinase BMX protein, from Human, contains 675 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis, Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins, Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation, Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility, Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis, Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation, Also involved in interleukin-6 (IL6) induced differentiation, Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts, May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1, May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Zinc finger protein 41 protein, from Human, contains 821 amino acids, has 17 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger.

C2H2-type 2; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Platelet endothelial cell adhesion molecule protein, from Bovine, contains 739 amino acids, has 6 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions, Tyr-689 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes, Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions, Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils, Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal, Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes, Modulates bradykinin receptor BDKRB2 activation, Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells, Induces susceptibility to atherosclerosis


This is CDK-activating kinase assembly factor MAT1 protein, from Human, contains 309 amino acids, has 1 RING-type Zinc finger.

RING-type

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex, CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts, Involved in cell cycle control and in RNA transcription by RNA polymerase II


This is CDK-activating kinase assembly factor MAT1 protein, from Mouse, contains 309 amino acids, has 1 RING-type Zinc finger.

RING-type


This is GATA-binding factor A protein, from Fruit fly, contains 540 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development, Involved in determining dorsal cell fate, Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors, It is the only factor to directly activate AS-C genes


This is Diacylglycerol kinase epsilon protein, from Human, contains 567 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:19744926, PubMed:22108654, PubMed:21477596, PubMed:23949095), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:8626589, PubMed:15544348), Also plays an important role in the biosynthesis of complex lipids (PubMed:8626589), Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:19744926, PubMed:22108654, PubMed:23274426), Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (PubMed:22108654)


This is Arf-GAP domain and FG repeat-containing protein 1 protein, from Human, contains 562 amino acids, has 1 C4-type Zinc finger.

Required for vesicle docking or fusion during acrosome biogenesis (By similarity), May play a role in RNA trafficking or localization, In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm, This step is essential for HIV-1 replication


This is FYVE, RhoGEF and PH domain-containing protein 1 protein, from Mouse, contains 960 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Plays a role in regulating the actin cytoskeleton and cell shape


This is Guanine nucleotide exchange factor VAV2 protein, from Human, contains 878 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases, Plays an important role in angiogenesis, Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity)


This is Zinc finger protein 133 protein, from Human, contains 654 amino acids, has 14 C2H2-type Zinc finger, has 1 C2H2-type 15; atypical Zinc finger.

C2H2-type 15; atypical

May be involved in transcriptional regulation as a repressor


This is Zinc finger protein 140 protein, from Human, contains 457 amino acids, has 10 C2H2-type Zinc finger.


This is Zinc finger protein 131 protein, from Human, contains 623 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 4; degenerate

Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity), May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling


This is Zinc finger protein 135 protein, from Human, contains 658 amino acids, has 16 C2H2-type Zinc finger.

Plays a role in the regulation of cell morphology and cytoskeletal organization, May be involved in transcriptional regulation


This is Zinc finger protein 138 protein, from Human, contains 262 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger.

C2H2-type 2; degenerate

C2H2-type 3; degenerate

C2H2-type 5; degenerate

C2H2-type 6; degenerate


This is Zinc finger protein 143 protein, from Human, contains 638 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional activator, Activates the gene for selenocysteine tRNA (tRNAsec), Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters, Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8

Belongs to the GLI C2H2-type zinc-finger protein family


This is RNA-binding protein 5 protein, from Human, contains 815 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type; atypical Zinc finger.

C2H2-type; atypical

Component of the spliceosome A complex, Regulates alternative splicing of a number of mRNAs, May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron, May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2, In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis, In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis


This is Beta-chimaerin protein, from Human, contains 468 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

GTPase-activating protein for p21-rac, Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors


This is Diacylglycerol kinase theta protein, from Human, contains 942 amino acids, has 3 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9099683, PubMed:11309392, PubMed:22627129), Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701), Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281), Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity), Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701)


This is Regulatory protein MIG2 protein, from Baker's yeast, contains 382 amino acids, has 2 C2H2-type Zinc finger.

Involved in glucose repression of the SUC2 gene

Belongs to the creA/MIG C2H2-type zinc-finger protein family


This is Glutamine sensor PIB2 protein, from Baker's yeast, contains 635 amino acids, has 1 FYVE-type; atypical Zinc finger.

FYVE-type; atypical

Functions as an intracellular glutamine sensor that directly activates the TORC1 signaling pathway, to promote cell growth when glutamine is available (PubMed:34535752, PubMed:29698392, PubMed:28483912, PubMed:26510498, PubMed:32801125), May play a role in repressing NPR1 activity independently of TORC1 signaling (PubMed:28993463)


This is Zinc finger chaperone ZPR1 protein, from Baker's yeast, contains 486 amino acids, has 2 C4-type Zinc finger.

Acts as a protein folding chaperone for elongation factor 1-alpha


This is Methionine aminopeptidase 1 protein, from Human, contains 386 amino acids, has 1 C6H2-type Zinc finger.

Cotranslationally removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val), Required for normal progression through the cell cycle

Belongs to the peptidase M24A family, Methionine aminopeptidase type 1 subfamily


This is Pre-mRNA-splicing factor CWC24 protein, from Baker's yeast, contains 259 amino acids, has 1 C3H1-type Zinc finger, has 1 RING-type Zinc finger.

RING-type


This is mRNA decay activator protein ZFP36 protein, from Bovine, contains 324 amino acids, has 2 C3H1-type Zinc finger.

Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis, Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery, Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation, Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, Self regulates by destabilizing its own mRNA, Binds to 3'-UTR ARE of numerous mRNAs, Binds also to ARE of its own mRNA, Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages, Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response, Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia, Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs), Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA, Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA, Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs, Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs, May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro, Involved in the delivery of target ARE-mRNAs to processing bodies (PBs), In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing, Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages, Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion, Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis, Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells


This is DNA-directed RNA polymerases I, II, and III subunit RPABC4 protein, from Human, contains 58 amino acids, has 1 C4-type Zinc finger.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively

Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family


This is CDC48-associated ubiquitin-like/zinc finger protein 1 protein, from Baker's yeast, contains 274 amino acids, has 1 AN1-type Zinc finger.

Promotes efficient arsenite-induced clearance of stress granules (SGs) (PubMed:29804830), May have a role in the ubiquitin-proteasome system (UPS) protecting cells from metalloid-induced proteotoxicity (PubMed:24121501, PubMed:24297164)


This is E3 ubiquitin-protein ligase DMA2 protein, from Baker's yeast, contains 522 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes, Involved in nutritional control of the cell cycle, Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck


This is J domain-containing protein APJ1 protein, from Baker's yeast, contains 528 amino acids, has 1 CR-type Zinc finger.

CR-type

Putative chaperone involved in protein folding, Interferes with propagation of [PSI+] prion when overproduced


This is Transcriptional regulator CRZ1 protein, from Baker's yeast, contains 678 amino acids, has 2 C2H2-type Zinc finger.

Involved in the regulation of calcium ion homeostasis, Binds to the calcineurin-dependent response element, Transcriptionally regulates PMC1, PMR1, PMR2A and FKS2


This is Probable ERAD-associated E3 ubiquitin-protein ligase ASI1 protein, from Baker's yeast, contains 676 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain, Required for ERG11 degradation (PubMed:25236469), Negative regulator of SPS-sensor signaling, Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444), Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748)


This is CCHC-type zinc finger nucleic acid binding protein protein, from Mouse, contains 178 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity), Has a role as transactivator of the Myc promoter (PubMed:12706888), Binds single-stranded RNA in a sequence-specific manner (By similarity), Binds G-rich elements in target mRNA coding sequences (By similarity), Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity)


This is ERAD-associated E3 ubiquitin-protein ligase ASI1 protein, from Baker's yeast, contains 624 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which transfers ubiquitin to substrates promoting their degradation, Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain, Required for ERG11 degradation (PubMed:25236469), Negative regulator of SPS-sensor signaling, Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:16735580, PubMed:17085444), Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748)


This is Proto-oncogene vav protein, from Rat, contains 843 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation


This is Ubiquitin carboxyl-terminal hydrolase A protein, from Social amoeba, contains 837 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate


This is Transcriptional activator/repressor MOT3 protein, from Baker's yeast, contains 490 amino acids, has 2 C2H2-type Zinc finger.

Transcription factor that affects the expression of a large set of genes, Recognizes and binds to the consensus sequence 5'-[CAT]AGG[TC]A-3' in the promoter region, Plays a major role in the repression of a specific subset of hypoxic genes (e,g, ANB1, DAN1 and HEM13) under aerobic conditions, Acts synergistically with the transcription factor ROX1 to recruit the general repression complex SSN6-TUP1 to the promoter of hypoxic genes, Represses transcription of ergosterol biosynthetic genes, Negatively regulates pheromone-induced gene expression, Can act as a transcriptional activator (e,g, of genes like CYC1, SUC2 and the Ty long terminal repeat delta promoter)


This is Sodium channel subunit beta-2 protein, from Rat, contains 215 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel, The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli, Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier

Belongs to the sodium channel auxiliary subunit SCN2B (TC 8,A,17) family


This is Oxysterols receptor LXR-beta protein, from Human, contains 460 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920), Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4), Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8, Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity), Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity), Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity), Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity), Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957)


This is Brevican core protein protein, from Rat, contains 883 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a role in the terminally differentiating and the adult nervous system during postnatal development, Could stabilize interactions between hyaluronan (HA) and brain proteoglycans, Isoform 2 may function as a chondroitin sulfate-bearing cell surface receptor

Belongs to the aggrecan/versican proteoglycan family


This is Microfibril-associated glycoprotein 3 protein, from Human, contains 362 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Component of the elastin-associated microfibrils


This is Nuclear receptor subfamily 2 group C member 2 protein, from Rat, contains 596 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan nuclear receptor that can act as a repressor or activator of transcription, An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways, May regulate gene expression during the late phase of spermatogenesis, Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation, Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, Plays a fundamental role in early embryonic development and embryonic stem cells, Required for normal spermatogenesis and cerebellum development, Appears to be important for neurodevelopmentally regulated behavior (By similarity)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Peroxisome biogenesis factor 2 protein, from Mouse, contains 305 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity), PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity), Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (By similarity), Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883)


This is Tyrosine-protein kinase receptor TYRO3 protein, from Mouse, contains 880 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6, Regulates many physiological processes including cell survival, migration and differentiation, Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules, Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity, Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes, TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization, Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Tyrosine-protein kinase receptor TYRO3 protein, from Rat, contains 880 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6, Regulates many physiological processes including cell survival, migration and differentiation, Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules, Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity, Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes, TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization, Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity)


This is DNA replication licensing factor mcm2 protein, from African clawed frog, contains 886 amino acids, has 1 C4-type Zinc finger.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity, Required for the entry in S phase and for cell division


This is V(D)J recombination-activating protein 2 protein, from Human, contains 527 amino acids, has 1 PHD-type; atypical Zinc finger.

PHD-type; atypical

Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination, V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments, DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends, The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps, The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes, The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele, In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1, It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity)


This is IgG receptor FcRn large subunit p51 protein, from Human, contains 365 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29

Belongs to the immunoglobulin superfamily


This is Myc-associated zinc finger protein protein, from Human, contains 477 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 6; atypical

Binds DNA and functions as a transcriptional activator


This is Ubiquitin carboxyl-terminal hydrolase 5 protein, from Mouse, contains 858 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers, Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly, Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity)


This is Myc-associated zinc finger protein protein, from Mouse, contains 477 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 6; atypical Zinc finger.

C2H2-type 6; atypical

Transcriptional regulator (By similarity), Acts as a transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide (PubMed:1454839)


This is Transcription factor collier protein, from Fruit fly, contains 575 amino acids, has 1 C5-type Zinc finger.

May act as a 'second-level regulator' of head patterning, Required for establishment of the PS(-1)/PS0 parasegmental border and formation of the intercalary segment, Required for expression of the segment polarity genes hedgehog, engrailed and wingless, and the segment-identity genes CAP and collar in the intercalary segment, Required at the onset of the gastrulation for the correct formation of the mandibular segment


This is Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic protein, from Mouse-ear cress, contains 488 amino acids, has 1 C4-type Zinc finger.

Component of the acetyl coenzyme A carboxylase (ACC) complex, Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA


This is E3 ubiquitin-protein ligase Mdm2 protein, from Dog, contains 487 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome, Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Also acts as a ubiquitin ligase E3 toward itself and ARRB1, Permits the nuclear export of p53/TP53, Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein, Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation, Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53, Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways, Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus, Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation, Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells, Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity), Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity), Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity)


This is E3 ubiquitin-protein ligase Mdm2 protein, from Horse, contains 491 amino acids, has 1 RanBP2-type Zinc finger, has 1 RING-type Zinc finger.

RING-type


This is RNA-binding protein FUS protein, from Mouse, contains 518 amino acids, has 1 RanBP2-type Zinc finger.

DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response, Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing, Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay, Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (By similarity), In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (PubMed:16317045, PubMed:25968143)


This is Pro-neuregulin-2, membrane-bound isoform protein, from Mouse, contains 756 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors, May also promote the heterodimerization with the EGF receptor


This is Junctional adhesion molecule B protein, from Human, contains 298 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068), Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068), At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068), Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159), Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135), Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity), Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity), During myogenesis, it is involved in myocyte fusion (By similarity), May also play a role in angiogenesis (By similarity)


This is Tyrosine-protein kinase Mer protein, from Rat, contains 994 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6, Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis), Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules, Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1, MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment, Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis, Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity)


This is Krueppel-like factor 3 protein, from Human, contains 345 amino acids, has 3 C2H2-type Zinc finger.

Binds to the CACCC box of erythroid cell-expressed genes, May play a role in hematopoiesis (By similarity)


This is Estrogen receptor protein, from Zebrafish, contains 569 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Peroxisome proliferator-activated receptor gamma protein, from Chinese hamster, contains 475 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase, It therefore controls the peroxisomal beta-oxidation pathway of fatty acids, Key regulator of adipocyte differentiation and glucose homeostasis, ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer, Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses, Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels


This is Acetylcholine-binding protein protein, from Great pond snail, contains 229 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

Binds to acetylcholine, Modulates neuronal synaptic transmission

To the extracellular portion of ligand-gated ionic channels family


This is Zinc finger protein DPF3 protein, from Mouse, contains 378 amino acids, has 1 C2H2-type Zinc finger, has 2 PHD-type Zinc finger.

PHD-type

PHD-type

Acts as a regulator of myogenesis in cooperation with HDGFL2 (PubMed:32459350), Mediates the interaction of HDGFL2 with the BAF complex (PubMed:32459350), HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350)


This is E3 ubiquitin-protein ligase RNF216 protein, from Mouse, contains 853 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome, Promotes degradation of TRAF3, TLR4 and TLR9, Contributes to the regulation of antiviral responses, Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production, Promotes TNF and RIP mediated apoptosis


This is Krueppel-like factor 16 protein, from Mouse, contains 251 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences, It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Forkhead box protein P1 protein, from Mouse, contains 705 amino acids, has 1 C2H2-type Zinc finger.

Involved in transcriptional regulation in embryonic stem cells (ESCs), Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes, Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (By similarity), Promotes ESC self-renewal and pluripotency (PubMed:21924763)


This is Forkhead box protein P2 protein, from Mouse, contains 714 amino acids, has 1 C2H2-type Zinc finger.

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium, May also play a role in developing neural, gastrointestinal and cardiovascular tissues, Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential, Plays a role in synapse formation by regulating SRPX2 levels


This is Vacuolar protein sorting-associated protein 18 homolog protein, from Zebrafish, contains 974 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways, Believed to act as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity), May be involved in vesicle trafficking to the hepatocyte apical membrane and play a role in development of the intra-hepatic biliary tree, May target endosomes to the pigment granule in melanocytes, Essential for early embryonic development


This is Lethal(3)malignant brain tumor-like protein 2 protein, from Mouse, contains 703 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Putative Polycomb group (PcG) protein, PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility, Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis, Binds to monomethylated and dimethylated 'Lys-20' on histone H4, Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity)


This is Ubiquitin-ribosomal protein eS31y fusion protein protein, from Mouse-ear cress, contains 157 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome

In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family


This is Ubiquitin-ribosomal protein eS31z fusion protein protein, from Mouse-ear cress, contains 156 amino acids, has 1 C4-type Zinc finger.


This is Glucocorticoid receptor protein, from Rabbit, contains 772 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression


This is Zinc finger protein 280A protein, from Human, contains 542 amino acids, has 4 C2H2-type Zinc finger.


This is Interleukin-1 receptor accessory protein protein, from Rhesus macaque, contains 570 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978), Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity)

Belongs to the interleukin-1 receptor family


This is Interleukin-1 receptor accessory protein-like 1 protein, from Mouse, contains 695 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel, May activate the MAP kinase JNK (By similarity), Plays a role in neurite outgrowth (By similarity), During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590, PubMed:21940441)


This is Interleukin-1 receptor accessory protein-like 1 protein, from Rat, contains 696 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:17502602), May activate the MAP kinase JNK (By similarity), Plays a role in neurite outgrowth (PubMed:18801879), During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity)


This is Leukocyte immunoglobulin-like receptor subfamily A member 4 protein, from Human, contains 499 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354), Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760), Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439), Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354), Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760)


This is Interleukin-1 receptor accessory protein-like 1 protein, from Chimpanzee, contains 696 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel, May activate the MAP kinase JNK (By similarity), Plays a role in neurite outgrowth (By similarity), During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity)


This is Nanos homolog 2 protein, from Human, contains 138 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate, Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate, Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased, Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis, Required for the maintenance of the spermatogonial stem cell population, Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity)


This is Nanos homolog 2 protein, from Mouse, contains 136 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate, Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate, Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased, Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis, Required for the maintenance of the spermatogonial stem cell population, Not essential for the assembly of P-bodies but is required for the maintenance of their normal state


This is Nanos homolog 3 protein, from Human, contains 173 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase, Affects cell proliferation probably by repressing translation of specific mRNAs, Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways, Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis


This is Nanos homolog 3 protein, from Mouse, contains 178 amino acids, has 1 Nanos-type Zinc finger.

Nanos-type


This is Nuclear protein localization protein 4 homolog protein, from Mouse, contains 608 amino acids, has 1 RanBP2-type Zinc finger.

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome, The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity), Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity)


This is MAM domain-containing glycosylphosphatidylinositol anchor protein 2 protein, from Mouse, contains 949 amino acids, has 6 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

May be involved in cell-cell interactions


This is E3 ubiquitin-protein ligase SIAH1A protein, from Mouse, contains 282 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes, Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP, Confers constitutive instability to HIPK2 through proteasomal degradation, It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling, Has some overlapping function with SIAH2 (By similarity), Required for completion of meiosis I in males (PubMed:11884614), Induces apoptosis in cooperation with PEG3 (PubMed:10681424), Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus, GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity), Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed:24809345), Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1

Belongs to the SINA (Seven in absentia) family


This is E3 ubiquitin-protein ligase sina protein, from Fruit fly, contains 314 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons, Also involved in external sensory organ development


This is Large ribosomal subunit protein eL43 protein, from Human, contains 92 amino acids, has 1 C4-type Zinc finger.

Component of the large ribosomal subunit, The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell

Belongs to the eukaryotic ribosomal protein eL43 family


This is Large ribosomal subunit protein eL43 protein, from Mouse, contains 92 amino acids, has 1 C4-type Zinc finger.

Component of the large ribosomal subunit (PubMed:36517592), The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)


This is Beta-2-microglobulin protein, from Human, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system, Exogenously applied M,tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553)

Belongs to the beta-2-microglobulin family


This is Beta-2-microglobulin protein, from Western lowland gorilla, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system (By similarity)


This is Aprataxin protein, from Dog, contains 342 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair, Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species, Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined, Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity), Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)


This is Aprataxin protein, from Chicken, contains 316 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair, Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species, Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241), Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity), Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)


This is Large ribosomal subunit protein eL37 protein, from Human, contains 97 amino acids, has 1 C4-type Zinc finger.

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547), The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547)

Belongs to the eukaryotic ribosomal protein eL37 family


This is Estrogen-related receptor gamma protein, from Human, contains 458 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that acts as transcription activator in the absence of bound ligand, Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity), Induces the expression of PERM1 in the skeletal muscle


This is Estrogen-related receptor gamma protein, from Mouse, contains 458 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that acts as transcription activator in the absence of bound ligand, Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements, Induces the expression of PERM1 in the skeletal muscle


This is Estrogen-related receptor gamma protein, from Rat, contains 458 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Orphan receptor that acts as transcription activator in the absence of bound ligand, Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements, Induces the expression of PERM1 in the skeletal muscle (By similarity)


This is CCHC-type zinc finger nucleic acid binding protein protein, from Human, contains 177 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type


This is CCHC-type zinc finger nucleic acid binding protein protein, from Rat, contains 177 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity), Has a role as transactivator of the Myc promoter (By similarity), Binds single-stranded RNA in a sequence-specific manner (PubMed:7788528), Binds G-rich elements in target mRNA coding sequences (By similarity), Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity)


This is E3 ubiquitin-protein ligase RBX1 protein, from Human, contains 108 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:11961546, PubMed:22748924), CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346), The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components, As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation, Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate, Probably also stimulates CDC34 autoubiquitination, May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair, Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M, Involved in the ubiquitination of KEAP1, ENC1 and KLHL41, In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM, As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177)


This is E3 ubiquitin-protein ligase RBX1 protein, from Mouse, contains 108 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460, PubMed:33590678), CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity), The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity), As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity), Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity), Probably also stimulates CDC34 autoubiquitination (By similarity), May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity), Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity), Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity), In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity), As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (By similarity)


This is Transcription initiation factor IIB protein, from Mouse, contains 316 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II), Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA, Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex, Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle, Associates with chromatin to core promoter-specific regions, Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element, Modulates transcription start site selection, Exhibits also autoacetyltransferase activity that contributes to the activated transcription


This is Transcription initiation factor IIB protein, from Rat, contains 316 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Guinea pig, contains 156 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome, Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Human, contains 156 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome (PubMed:9582194), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Rat, contains 156 amino acids, has 1 C4-type Zinc finger.


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Mouse, contains 156 amino acids, has 1 C4-type Zinc finger.

Component of the 40S subunit of the ribosome (PubMed:19754430), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)


This is Ubiquitin-ribosomal protein eS31 fusion protein protein, from Bovine, contains 156 amino acids, has 1 C4-type Zinc finger.


This is DnaJ homolog subfamily A member 1 protein, from Rat, contains 397 amino acids, has 1 CR-type Zinc finger.

CR-type

Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis, Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV, Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (By similarity), Co-chaperone for HSPA8/Hsc70, Plays a role in protein transport into mitochondria via its role as co-chaperone (PubMed:10816573)


This is DnaJ homolog subfamily A member 1 protein, from Mouse, contains 397 amino acids, has 1 CR-type Zinc finger.

CR-type

Co-chaperone for HSPA8/Hsc70, Plays a role in protein transport into mitochondria via its role as co-chaperone, Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro), Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity), Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis


This is Thyroid hormone receptor alpha protein, from Mouse, contains 492 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine, Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Thyroid hormone receptor alpha protein, from Rat, contains 492 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear hormone receptor that can act as a repressor or activator of transcription, High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine


This is Beta-2-microglobulin protein, from White-tufted-ear marmoset, contains 119 amino acids, has 1 Ig-like C1-type Immunoglobulin domain.

Ig-like C1-type

Component of the class I major histocompatibility complex (MHC), Involved in the presentation of peptide antigens to the immune system (By similarity)


This is Transcription elongation factor SPT4 protein, from Human, contains 117 amino acids, has 1 C4-type Zinc finger.

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II, DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A, DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter, Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex, DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II, TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme, Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites, DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat, DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences


This is Protein kinase C gamma type protein, from Mouse, contains 697 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress, Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression, In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning, May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity, May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain, May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors, May also contribute to chronic morphine-induced changes in nociceptive processing, Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation, Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors, During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury, Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum, Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress, Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage, Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding, Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (PubMed:23185022)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Protein kinase C gamma type protein, from Rat, contains 697 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress, Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression, In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning, May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity, May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain, May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors, May also contributes to chronic morphine-induced changes in nociceptive processing, Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation, Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors, During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury, Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum, Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress, Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage, Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding, Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity)


This is Protein kinase C beta type protein, from Rat, contains 671 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation, Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1, Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity, Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer, Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A, In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade, Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4, Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1, Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression, In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction, Also involved in triglyceride homeostasis (By similarity), Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription


This is Protein kinase C beta type protein, from Mouse, contains 671 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation, Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1, Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity, Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer, Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A, In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade, Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4, Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1, Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression, In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction, Also involved in triglyceride homeostasis, Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity)


This is Nuclear receptor subfamily 6 group A member 1 protein, from African clawed frog, contains 435 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Probable orphan nuclear receptor, Binds to a response element containing repeats of the motif 5'-AGGTCA-3', Required for anterior-posterior patterning during organogenesis, Acts with chordin to play a role in patterning the midbrain-hindbrain, Isoform Em is required for integrin-mediated cell matrix interaction during neurulation and for the morphogenetic movements leading to formation of the neural tube, Also mediates the effect of retinoic acid on primary neurogenesis

Belongs to the nuclear hormone receptor family, NR6 subfamily


This is TNF receptor-associated factor 5 protein, from Mouse, contains 558 amino acids, has 1 RING-type Zinc finger, has 2 TRAF-type Zinc finger.

RING-type

TRAF-type

TRAF-type

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases, Mediates activation of NF-kappa-B and probably JNK, Seems to be involved in apoptosis, Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR

Belongs to the TNF receptor-associated factor family, A subfamily