This is Mast/stem cell growth factor receptor kita protein, from Zebrafish, contains 976 amino acids, has 5 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function, Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes, Required for the differentiation of some, but not all, melanocytes, Not essential for hematopoiesis or primordial germ cell development

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Fibroblast growth factor receptor 2 protein, from Zebrafish, contains 817 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development, Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development, Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development, Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts, Phosphorylates PLCG1, FRS2 and PAK4, Ligand binding leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation, Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling, Over-expressed FGFR2 promotes activation of STAT1 (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily


This is Tyrosine-protein kinase BTK protein, from Chicken, contains 657 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:8691147, PubMed:12912915), Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity), After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (By similarity), PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (By similarity), BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (By similarity), Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (By similarity), The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (By similarity), Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (By similarity), Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (By similarity), BTK also plays a critical role in transcription regulation (By similarity), Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:10811866), BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (By similarity), Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity), Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (By similarity), GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (By similarity), ARID3A and NFAT are other transcriptional target of BTK (By similarity), BTK is required for the formation of functional ARID3A DNA-binding complexes (By similarity), There is however no evidence that BTK itself binds directly to DNA (By similarity), BTK has a dual role in the regulation of apoptosis (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Baculoviral IAP repeat-containing protein 7-A protein, from African clawed frog, contains 401 amino acids, has 1 RING-type Zinc finger.

RING-type

Weak apoptotic suppressor, Has E3 ubiquitin-protein ligase activity, Weak inhibitor of caspase activity


This is Zinc finger protein 467 protein, from Mouse, contains 594 amino acids, has 12 C2H2-type Zinc finger.

Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow, Enhances the osteoclast-supporting ability of stromal cells, Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE), Transactivates several promoters including FOS, OSM and PPARG, Recruits a histone deacetylase complex

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger and BTB domain-containing protein 20 protein, from Mouse, contains 741 amino acids, has 5 C2H2-type Zinc finger.

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity), Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912)


This is Sodium channel modifier 1 protein, from Mouse, contains 229 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:17656373, PubMed:12920299), Plays a role in the regulation of primary cilia length and Hedgehog signaling (By similarity)


This is Histone H4 transcription factor protein, from Mouse, contains 503 amino acids, has 8 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 4; degenerate

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter, Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT, Also activates transcription of the ATM and PRKDC genes, Autoregulates its expression by associating with its own promoter


This is Zinc finger protein GLIS1 protein, from Mouse, contains 789 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Acts as both a repressor and activator of transcription (PubMed:12042312, PubMed:12385751, PubMed:21654807), Binds to the consensus sequence 5'-GACCACCCAC-3' (PubMed:12042312), By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807, PubMed:30544251), Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (PubMed:30544251)

Belongs to the GLI C2H2-type zinc-finger protein family


This is Netrin receptor UNC5D protein, from Mouse, contains 956 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for the netrin NTN4 that promotes neuronal cell survival (PubMed:21216843), Plays a role in cell-cell adhesion and cell guidance, Receptor for netrin involved in cell migration (By similarity), Plays a role in the regulation of neuronal cell migration in the developing brain via its interaction with FLRT2 (PubMed:21673655), Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:21673655), May play a role in apoptosis in response to DNA damage, It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity), Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (PubMed:26235030)


This is Netrin receptor UNC5B protein, from Mouse, contains 945 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance, Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding, Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity), Functions as netrin receptor that negatively regulates vascular branching during angiogenesis (PubMed:15510105), Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (PubMed:15510105), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand, Mediates apoptosis by activating DAPK1, In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity)


This is Netrin receptor UNC5A protein, from Mouse, contains 898 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance, Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1, Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin, Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion, It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand


This is Krueppel-like factor 11 protein, from Mouse, contains 502 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor, Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity), Represses transcription of SMAD7 which enhances TGF-beta signaling, Induces apoptosis

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Serine/threonine-protein kinase D3 protein, from Mouse, contains 889 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC, Involved in resistance to oxidative stress (By similarity)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is Endonuclease 8-like 3 protein, from Mouse, contains 606 amino acids, has 1 FPG-type Zinc finger, has 1 RanBP2-type Zinc finger, has 2 GRF-type Zinc finger.

FPG-type

GRF-type

GRF-type

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161), Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity), In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161), No activity on 8-oxoG detected (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161), Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161), In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161)


This is E3 ubiquitin-protein ligase TRIM68 protein, from Mouse, contains 485 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Functions as a ubiquitin E3 ligase, Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity


This is Arf-GAP domain and FG repeat-containing protein 1 protein, from Mouse, contains 561 amino acids, has 1 C4-type Zinc finger.

Required for vesicle docking or fusion during acrosome biogenesis, May play a role in RNA trafficking or localization


This is Matrin-3 protein, from Mouse, contains 846 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network, In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs, Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway, Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs, May bind to specific miRNA hairpins


This is DNA/RNA-binding protein KIN17 protein, from Mouse, contains 391 amino acids, has 1 C2H2-type Zinc finger.

Involved in DNA replication and the cellular response to DNA damage, May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes, May play a role in illegitimate recombination and regulation of gene expression, May participate in mRNA processing, Binds, in vitro, to double-stranded DNA, Also shown to bind preferentially to curved DNA in vitro and in vivo, Binds via its C-terminal domain to RNA in vitro


This is Ubiquitin carboxyl-terminal hydrolase 45 protein, from Mouse, contains 813 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Catalyzes the deubiquitination of SPDL1 (By similarity), Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (By similarity), May be involved in the maintenance of photoreceptor function (PubMed:30573563), May play a role in normal retinal development (By similarity), Plays a role in cell migration (By similarity)


This is Rab effector MyRIP protein, from Mouse, contains 856 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab effector protein involved in melanosome transport, Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A, May link RAB27A-containing vesicles to actin filaments, Functions as a protein kinase A-anchoring protein (AKAP), May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release


This is Zinc finger protein 131 protein, from Mouse, contains 619 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger.

C2H2-type 4; degenerate

May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling (By similarity), Plays a role during development and organogenesis as well as in the function of the adult central nervous system


This is Optineurin protein, from Mouse, contains 584 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8, Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation, Plays a role in the activation of innate immune response during viral infection, Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation, In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta, Plays a neuroprotective role in the eye and optic nerve, May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52


This is Probable E3 ubiquitin-protein ligase IRF2BPL protein, from Mouse, contains 775 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins, Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway, Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity), Also acts as a transcriptional regulator of genes controlling female reproductive function, May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)


This is Protein lin-28 homolog A protein, from Mouse, contains 209 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:17473174, PubMed:18604195, PubMed:18566191, PubMed:18292307, PubMed:19703396, PubMed:23102813, PubMed:24209617), Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (PubMed:26045559), 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis, Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization, Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA, Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (PubMed:17473174), Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c, Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferaseS, This results in the terminal uridylation of target pre-miRNAs, Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation, The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:19703396, PubMed:28671666), Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins (PubMed:23102813), Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation, Which, with the let-7 repression may enhance tissue repair in adult tissue (PubMed:24209617)


This is Zinc finger CCCH-type antiviral protein 1 protein, from Rat, contains 776 amino acids, has 4 C3H1-type Zinc finger.

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs, Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end, It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end, Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV), Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation


This is Metastasis-associated protein MTA1 protein, from Mouse, contains 715 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:20682799, PubMed:20071335), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity), In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180), In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:20071335, PubMed:21965678), Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex (PubMed:17671180, PubMed:21965678), Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (PubMed:20682799), Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:20071335, PubMed:19805145), Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670, PubMed:19805145), Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (PubMed:24089055), Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (PubMed:24089055), Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (PubMed:24089055), With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (PubMed:28982712)


This is CD226 antigen protein, from Mouse, contains 333 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell, Cell surface receptor for NECTIN2, Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG, Competes with PVRIG for NECTIN2-binding


This is Aprataxin protein, from Rat, contains 329 amino acids, has 1 C2H2-type Zinc finger.

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair, Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species, Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined, Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity), Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)


This is Transcription factor COE4 protein, from Mouse, contains 599 amino acids, has 1 C5-type Zinc finger.

Transcription factor (PubMed:12139918), Positively modulates transcription, perhaps less strongly than other early B cell factor/EBF family proteins (PubMed:12139918), Binds an EBF1/Olf-1 consensus site in vitro (PubMed:12139918)


This is E3 ubiquitin-protein ligase CBL-B protein, from Rat, contains 938 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome, Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways, In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production, Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation, In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy, In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation, Slightly promotes SRC ubiquitination, May be involved in EGFR ubiquitination and internalization, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3, In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity)


This is Trem-like transcript 1 protein protein, from Mouse, contains 317 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor that may play a role in the innate and adaptive immune response


This is DNA-directed RNA polymerases II, IV and V subunit 9B protein, from Mouse-ear cress, contains 114 amino acids, has 1 TFIIS-type Zinc finger.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements, Required for RNA silencing

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is E3 ubiquitin-protein ligase BIG BROTHER protein, from Mouse-ear cress, contains 248 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that limits organ size, and possibly seed size, in a dose-dependent manner, Negatively regulates the duration of cell proliferation in leaves and petals independently of the major phytohormones (e,g, auxin, cytokinin, gibberellin, brassinosteroids, ethylene, abscisic acid, jasmonic acid), probably by targeting growth stimulators for degradation (PubMed:16461280, PubMed:18483219), Limits the proliferation of root meristematic cells (PubMed:28922745), Polyubiquitinates DA1 (PubMed:28167503), Involved in the promotion of leaf senescence, in addition to its function in restricting plant growth (PubMed:28003326), Possesses E3 ubiquitin-protein ligase activity in vitro (PubMed:16461280, PubMed:18483219, PubMed:28167503)


This is Ubiquitin carboxyl-terminal hydrolase 14 protein, from Mouse-ear cress, contains 797 amino acids, has 1 UBP-type; degenerate Zinc finger.

UBP-type; degenerate

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin, Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins, Involved in seed and embryo development


This is Polycomb group protein EMBRYONIC FLOWER 2 protein, from Mouse-ear cress, contains 631 amino acids, has 1 C2H2-type Zinc finger.

Polycomb group (PcG) protein, Involved in flowering processes by repressing unknown target genes and preventing reproductive development, Participates in polycomb group (PcG) protein complex-mediated (probably in complex with EMF1) silencing of the flower homeotic genes AGAMOUS (AG), PISTILLATA (PI), and APETALA3 (AP3), as well as of some regulatory genes such as ABSCISIC ACID INSENSITIVE3 (ABI3), LONG VEGETATIVE PHASE1 (LOV1), and FLOWERING LOCUS C (FLC) during vegetative development, by mediating trimethylation of histone 3 lysine 27 on the AG chromatin (H3K27me3), PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is E3 ubiquitin-protein ligase SP1 protein, from Mouse-ear cress, contains 343 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase involved in the regulation of protein import in the chloroplast, Associates with TOC complexes and mediates ubiquitination of TOC components, promoting their degradation via the ubiquitin-proteasome system (UPS), Plays a role in the reorganization of the TOC machinery, Involved in a mechanism that regulates plastid biogenesis via UPS (PubMed:23118188), Promotes stress tolerance by depleting the chloroplast protein import apparatus, which limits photosystem assembly and the potential for reactive oxygen species (ROS) formation (PubMed:26387714), May act as negative regulator of programmed cell death (PCD) during biotic stress (PubMed:20972793)


This is DEAD-box ATP-dependent RNA helicase 3, chloroplastic protein, from Mouse-ear cress, contains 748 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Nuclear genome-encoded factor involved in ribosome biogenesis in chloroplasts (PubMed:22576849, PubMed:23227895, PubMed:25043599), Binds specific group II introns in chloroplasts and facilitates their splicing, Is required for rRNA maturation in plastids and may contribute to the assembly of the large (50S) ribosomal subunit (PubMed:22576849), Required for normal development of chloroplasts (PubMed:22576849, PubMed:23227895, PubMed:25043599), Required for the expression of transcripts encoding plastid-localized enzymes involved in abscisic acid (ABA) biosynthesis, Required for maintenance of ABA levels and response to salt stress (PubMed:23227895), Possesses RNA chaperone activity for proper splicing of introns in chloroplasts, Essential for chloroplast function and abiotic stress responses (PubMed:25043599)

Belongs to the DEAD box helicase family, DDX21/DDX50 subfamily


This is Protein CRABS CLAW protein, from Mouse-ear cress, contains 181 amino acids, has 1 C4-type Zinc finger.

Transcription factor required for the initiation of nectary development, Also involved in suppressing early radial growth of the gynoecium, in promoting its later elongation and in fusion of its carpels by regulating both cell division and expansion, Establishes the polar differentiation in the carpels by specifying abaxial cell fate in the ovary wall, Regulates both cell division and expansion


This is Dof zinc finger protein DOF1.1 protein, from Mouse-ear cress, contains 331 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence, Enhances the DNA binding of OBF transcription factors to OCS elements (By similarity), Involved in the regulation of root development (PubMed:23057675), The PEAR proteins (e,g, DOF2,4, DOF5,1, DOF3,2, DOF1,1, DOF5,6 and DOF5,3) activate gene expression that promotes radial growth of protophloem sieve elements (PubMed:30626969), Element of a regulatory network controlling indole glucosinolates (IGS) biosynthesis, probably by inducing the expression of accurate genes (e,g, CYP83B1), Promotes apical dominance (PubMed:16740150)


This is PHD finger protein ALFIN-LIKE 7 protein, from Mouse-ear cress, contains 252 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Methyl-CpG-binding domain-containing protein 2 protein, from Mouse-ear cress, contains 272 amino acids, has 1 CW-type Zinc finger.

CW-type


This is GATA transcription factor 18 protein, from Mouse-ear cress, contains 295 amino acids, has 1 GATA-type Zinc finger.

GATA-type

Transcriptional factor that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters (including its own promoter and GATA21 promoter), thus regulating the expression of genes mostly involved in hormone responses and floral organ specification (including genes regulating hormones responses) (PubMed:23335616, PubMed:26390296), Regulates both flower and shoot apical meristem (SAM) development, especially for establishing organ boundaries in shoots and flowers, probably by controlling the number and position of WUS-expressing cells (PubMed:15367721, PubMed:23335616), Coregulates, with AGO10/PNH, the shoot apical meristem (SAM) organization, Regulates floral organ development via the promotion of JAG and NPR5/BOP2 expression, Modulates cytokinin homeostasis in organ boundaries by regulating CKX3 expression (PubMed:26390296), Involved in cell proliferation and differentiation (PubMed:15367721), Required to position the inductive proembryo boundary via the regulation of gene expression and for early embryonic development (PubMed:20643354), Together with GIF1/AN3, mediates cotyledon identity by preventing ectopic root formation through the repression of PLT1 expression (PubMed:22669825)

Belongs to the type IV zinc-finger family, Class B subfamily


This is Cyclic dof factor 3 protein, from Mouse-ear cress, contains 448 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity), Regulates a photoperiodic flowering response, Transcriptional repressor of 'CONSTANS' expression


This is E3 ubiquitin-protein ligase ATL31 protein, from Mouse-ear cress, contains 368 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that is required for the plant C/N response during seedling growth transition, May be involved in the early steps of the plant defense signaling pathway

Belongs to the RING-type zinc finger family, ATL subfamily


This is Protein MARD1 protein, from Mouse-ear cress, contains 263 amino acids, has 1 FLZ-type Zinc finger.

FLZ-type

May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway (PubMed:24600465), Involved in seed dormancy control (PubMed:15159630)


This is Cellulose synthase A catalytic subunit 8 [UDP-forming] protein, from Mouse-ear cress, contains 985 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation, Involved in the secondary cell wall formation, Required for the xylem cell wall thickening

Belongs to the glycosyltransferase 2 family, Plant cellulose synthase subfamily


This is Androgen receptor protein, from Spotted hyena, contains 912 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation, Transcription activation is also down-regulated by NR0B2, Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Zinc finger protein 444 protein, from Human, contains 327 amino acids, has 4 C2H2-type Zinc finger.

Transcriptional regulator, Binds to the 5'-flanking critical region of the SCARF1 promoter


This is Cell adhesion molecule 3 protein, from Human, contains 398 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Involved in the cell-cell adhesion, Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3, Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)


This is Leukocyte immunoglobulin-like receptor subfamily A member 2 protein, from Human, contains 483 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839), Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L,pneumophila, M,hyorhinis, S,pneumoniae, S,aureus and C,albicans (PubMed:27572839), Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839), Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839), Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839), In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404), In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506), Does not bind class I MHC antigens (PubMed:19230061)


This is Mitochondrial cardiolipin hydrolase protein, from Human, contains 252 amino acids, has 1 C3H1-type; atypical Zinc finger.

C3H1-type; atypical

Presents phospholipase and nuclease activities, depending on the different physiological conditions (PubMed:17028579, PubMed:21397847, PubMed:28063496), Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity (PubMed:26711011), Plays a key role in mitochondrial fusion and fission via its phospholipase activity (PubMed:17028579, PubMed:24599962, PubMed:26678338), In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid (PubMed:17028579, PubMed:26711011), Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission (PubMed:24599962), Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology, Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis (PubMed:26678338), Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation (PubMed:21397848), Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation (PubMed:26678338), The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis (PubMed:21397847, PubMed:21397848), Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA), MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins, Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts, piRNAs provide essential protection against the activity of mobile genetic elements, piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity), PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs (PubMed:21397847), Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner (By similarity)

Belongs to the phospholipase D family, MitoPLD/Zucchini subfamily


This is Protein odd-skipped-related 2 protein, from Human, contains 312 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger.

C2H2-type 5; degenerate

Belongs to the Odd C2H2-type zinc-finger protein family


This is E3 SUMO-protein ligase PIAS4 protein, from Human, contains 510 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:12511558, PubMed:12631292, PubMed:12727872, PubMed:15831457, PubMed:15976810, PubMed:22508508, PubMed:32832608), Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168 (PubMed:12511558, PubMed:12631292, PubMed:12727872, PubMed:15831457, PubMed:15976810, PubMed:22508508), Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway (PubMed:11388671), Involved in gene silencing (PubMed:11248056), In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations (PubMed:12727872, PubMed:15831457), Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678), Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs) (By similarity), Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:32832608), Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (PubMed:35013556)


This is Zinc finger protein 786 protein, from Human, contains 782 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 13 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 1 C2H2-type 7; degenerate Zinc finger.

C2H2-type 1; degenerate

C2H2-type 3; degenerate

C2H2-type 7; degenerate

May be involved in transcriptional regulation


This is Cell adhesion molecule 2 protein, from Human, contains 435 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation, Important for synapse organization, providing regulated trans-synaptic adhesion, Preferentially binds to oligodendrocytes


This is Zinc finger CCHC domain-containing protein 7 protein, from Human, contains 543 amino acids, has 4 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type


This is Leukocyte immunoglobulin-like receptor subfamily B member 2 protein, from Human, contains 597 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for class I MHC antigens, Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042), Involved in the down-regulation of the immune response and the development of tolerance, Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647), Competes with CD8A for binding to class I MHC antigens, Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885)


This is Fibroblast growth factor receptor-like 1 protein, from Human, contains 504 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Has a negative effect on cell proliferation


This is Ligand of Numb protein X 2 protein, from Human, contains 690 amino acids, has 1 RING-type Zinc finger.

RING-type


This is RING1 and YY1-binding protein protein, from Human, contains 228 amino acids, has 1 RanBP2-type Zinc finger.

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132), Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females, May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity), Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711), May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496), May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439), May bind to DNA (By similarity), May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911)


This is Zinc finger protein 276 protein, from Human, contains 614 amino acids, has 5 C2H2-type Zinc finger.


This is Zinc finger CCCH-type with G patch domain-containing protein protein, from Human, contains 531 amino acids, has 1 C3H1-type Zinc finger.

Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex, Does not bind DNA


This is TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 protein, from Human, contains 712 amino acids, has 1 RanBP2-type Zinc finger.


This is Zinc finger CCCH domain-containing protein 8 protein, from Human, contains 291 amino acids, has 3 C3H1-type Zinc finger.

Acts as a transcriptional repressor of the GATA3 promoter, Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity), Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780), Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis


This is E3 ubiquitin-protein ligase RNF10 protein, from Human, contains 811 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731), Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731), Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161), The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731), May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity), Acts as a regulator of Schwann cell differentiation and myelination (By similarity)


This is Zinc finger and BTB domain-containing protein 2 protein, from Human, contains 514 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 3; atypical

C2H2-type 4; atypical


This is Leukocyte immunoglobulin-like receptor subfamily A member 3 protein, from Human, contains 439 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Acts as soluble receptor for class I MHC antigens, Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2, Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes


This is E3 ubiquitin-protein ligase RNF182 protein, from Human, contains 247 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843), Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514)


This is ADP-ribosylation factor GTPase-activating protein 2 protein, from Human, contains 521 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum, Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes


This is ADP-ribosylation factor GTPase-activating protein 1 protein, from Human, contains 406 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1), Involved in membrane trafficking and /or vesicle transport, Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment, Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2, Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated, Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity)


This is Zinc finger protein 655 protein, from Human, contains 491 amino acids, has 6 C2H2-type Zinc finger.


This is Killer cell immunoglobulin-like receptor 3DL3 protein, from Human, contains 410 amino acids, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor on natural killer cells, May inhibit the activity of NK cells thus preventing cell lysis

Belongs to the immunoglobulin superfamily


This is Probable E3 ubiquitin-protein ligase TRIML2 protein, from Human, contains 437 amino acids, has 1 B box-type Zinc finger.

B box-type


This is E3 ubiquitin-protein ligase CBLL2 protein, from Human, contains 425 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger.

RING-type

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:20657603), May operate on tyrosine-phosphorylated SRC substrates (PubMed:22252131)


This is Zinc finger protein 366 protein, from Human, contains 744 amino acids, has 11 C2H2-type Zinc finger.

Has transcriptional repression activity, Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases


This is Zinc finger protein 513 protein, from Human, contains 541 amino acids, has 8 C2H2-type Zinc finger.

Transcriptional regulator that plays a role in retinal development and maintenance


This is E3 ubiquitin-protein ligase RNF152 protein, from Human, contains 203 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation, Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802), Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation, Induces apoptosis when overexpressed (PubMed:21203937)


This is Probable E3 ubiquitin-protein ligase DTX3 protein, from Human, contains 347 amino acids, has 1 RING-type Zinc finger.

RING-type

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity), Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity


This is Protein SREK1IP1 protein, from Human, contains 155 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Possible splicing regulator involved in the control of cellular survival


This is Zinc finger protein 383 protein, from Human, contains 475 amino acids, has 11 C2H2-type Zinc finger.

May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways


This is Probable E3 ubiquitin-protein ligase MARCHF10 protein, from Human, contains 808 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase (Probable), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Zinc finger and SCAN domain-containing protein 4 protein, from Human, contains 433 amino acids, has 4 C2H2-type Zinc finger.

Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency, Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation, Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity)


This is Zinc finger and BTB domain-containing protein 8B protein, from Human, contains 495 amino acids, has 2 C2H2-type Zinc finger.

May be involved in transcriptional regulation


This is Histone-lysine N-methyltransferase SMYD1 protein, from Human, contains 490 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation, Acts as a transcriptional repressor, Essential for cardiomyocyte differentiation and cardiac morphogenesis

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Zinc finger protein 511 protein, from Human, contains 252 amino acids, has 3 C2H2-type Zinc finger.


This is Lysine-specific histone demethylase 2 protein, from Human, contains 822 amino acids, has 1 CW-type Zinc finger.

CW-type

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor, Required for de novo DNA methylation of a subset of imprinted genes during oogenesis, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Demethylates both mono- and di-methylated 'Lys-4' of histone H3, Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4, Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:30970244)

Belongs to the flavin monoamine oxidase family


This is Zinc finger and SCAN domain-containing protein 1 protein, from Human, contains 408 amino acids, has 3 C2H2-type Zinc finger.


This is Zinc finger protein GLIS1 protein, from Human, contains 620 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Acts as both a repressor and activator of transcription (PubMed:21654807), Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity), By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807), Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity)


This is Zinc finger protein 114 protein, from Human, contains 417 amino acids, has 4 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase RNF149 protein, from Human, contains 400 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase, Ubiquitinates BRAF, inducing its proteasomal degradation


This is E3 ubiquitin-protein ligase RNF169 protein, from Human, contains 708 amino acids, has 1 RING-type Zinc finger.

RING-type

Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage, Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093), Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093), E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair


This is Zinc finger and BTB domain-containing protein 44 protein, from Human, contains 570 amino acids, has 4 C2H2-type Zinc finger.


This is E3 ubiquitin-protein ligase ZNRF1 protein, from Human, contains 227 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation, Plays a role in the establishment and maintenance of neuronal transmission and plasticity, Regulates Schwann cells differentiation by mediating ubiquitination of GLUL, Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable)


This is Zinc finger protein 439 protein, from Human, contains 499 amino acids, has 11 C2H2-type Zinc finger.


This is Zinc finger protein 540 protein, from Human, contains 660 amino acids, has 17 C2H2-type Zinc finger.


This is Polyhomeotic-like protein 3 protein, from Human, contains 983 amino acids, has 1 FCS-type Zinc finger.

FCS-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility


This is Zinc finger protein GLIS3 protein, from Human, contains 775 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger.

C2H2-type 2; atypical

Acts as both a repressor and activator of transcription, Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity)


This is NFAT activation molecule 1 protein, from Human, contains 270 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters, Activates the transcription of IL-13 and TNF-alpha promoters, May be involved in the regulation of B-cell, but not T-cell, development, Overexpression activates downstream effectors without ligand binding or antibody cross-linking


This is Zinc finger MIZ domain-containing protein 2 protein, from Human, contains 920 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors


This is Zinc finger protein 397 protein, from Human, contains 534 amino acids, has 9 C2H2-type Zinc finger.

Isoform 3 acts as a DNA-dependent transcriptional repressor


This is MAM domain-containing glycosylphosphatidylinositol anchor protein 1 protein, from Human, contains 955 amino acids, has 6 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity), Plays a role in the formation or maintenance of inhibitory synapses, May function by inhibiting the activity of NLGN2


This is Protein DBF4 homolog B protein, from Human, contains 615 amino acids, has 1 DBF4-type Zinc finger.

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation, Required for progression of S and M phases, The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle


This is Rab effector MyRIP protein, from Human, contains 859 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Rab effector protein involved in melanosome transport, Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A, May link RAB27A-containing vesicles to actin filaments, Functions as a protein kinase A-anchoring protein (AKAP), May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity)


This is TNFAIP3-interacting protein 2 protein, from Human, contains 429 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG, Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation, Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific, Required for stability of MAP3K8, Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival, May act as transcriptional coactivator when translocated to the nucleus, Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes


This is Cell adhesion molecule 4 protein, from Human, contains 388 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Involved in the cell-cell adhesion, Has calcium- and magnesium-independent cell-cell adhesion activity, May have tumor-suppressor activity


This is E3 ubiquitin-protein ligase TRIM58 protein, from Human, contains 486 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase induced during late erythropoiesis, Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex, May participate in the erythroblast enucleation process through regulation of nuclear polarization


This is E3 ubiquitin-protein ligase Praja-1 protein, from Human, contains 643 amino acids, has 1 RING-type Zinc finger.

RING-type

Has E2-dependent E3 ubiquitin-protein ligase activity, Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity), May be involved in protein sorting


This is E3 ubiquitin-protein ligase ZNRF2 protein, from Human, contains 242 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates


This is Leukocyte immunoglobulin-like receptor subfamily B member 4 protein, from Human, contains 448 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462), Receptor for FN1 (PubMed:34089617), Receptor for apolipoprotein APOE (PubMed:30333625), Receptor for ALCAM/CD166 (PubMed:29263213), Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699), Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736), This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617), Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213), Induces up-regulation of CD86 on dendritic cells (PubMed:19860908), Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462)


This is Leukocyte immunoglobulin-like receptor subfamily B member 1 protein, from Human, contains 650 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Receptor for class I MHC antigens, Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952), Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog, Ligand binding results in inhibitory signals and down-regulation of the immune response, Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis, Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release, Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885), Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647), Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799), Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251)


This is E3 ubiquitin-protein ligase COP1 protein, from Human, contains 731 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Involved in JUN ubiquitination and degradation, Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis, Ubiquitinates p53 independently of MDM2 or RCHY1, Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes, In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1, Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival, Ubiquitinates MTA1 leading to its proteasomal degradation, Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable)


This is Transcriptional repressor CTCFL protein, from Human, contains 663 amino acids, has 10 C2H2-type Zinc finger, has 1 C2H2-type 11; atypical Zinc finger.

C2H2-type 11; atypical

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers, Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR), Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2, This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity), Seems to act as tumor suppressor, In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter, Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters

Belongs to the CTCF zinc-finger protein family


This is Tyrosine-protein kinase receptor TYRO3 protein, from African clawed frog, contains 880 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be involved in cell adhesion processes, particularly in the central nervous system

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is E3 ubiquitin-protein ligase RNF183 protein, from Mouse, contains 190 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29300766), Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity), May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity)


This is Nectin-4 protein, from Mouse, contains 508 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1


This is V-set and transmembrane domain-containing protein 2A protein, from Mouse, contains 236 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation, Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway


This is E3 ubiquitin-protein ligase TRIM31 protein, from Mouse, contains 507 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:27929086, PubMed:27992402), Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402), Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086), Regulator of Src-induced anchorage independent cell growth (PubMed:19665990)


This is Cyclic AMP-dependent transcription factor ATF-7 protein, from Mouse, contains 413 amino acids, has 1 C2H2-type Zinc finger.

Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055), In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as Htr5b, STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (PubMed:19893493, PubMed:31294895, PubMed:30826729), Phosphorylation of ATF7 disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (PubMed:19893493), In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055), Also plays a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (PubMed:31958521)


This is WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 protein, from Mouse, contains 552 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease-inhibitor that contains multiple distinct protease inhibitor domains, Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)


This is T-cell immunoglobulin and mucin domain-containing protein 2 protein, from Mouse, contains 305 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090), Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823), Plays also an important role in the regulation of Th2 immunity (PubMed:16043519), Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982)

Belongs to the immunoglobulin superfamily, TIM family


This is SH3 and cysteine-rich domain-containing protein 2 protein, from Mouse, contains 408 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163), Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593)


This is Nuclear receptor ROR-beta protein, from Mouse, contains 470 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina, Regulates the expression of PTF1A synergistically with FOXN4

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Zinc finger protein 830 protein, from Mouse, contains 363 amino acids, has 1 C2H2-type Zinc finger.

May play a role in pre-mRNA splicing as component of the spliceosome (By similarity), Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity (PubMed:21191184, PubMed:23213458, PubMed:25168238, PubMed:15988037), During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation (PubMed:21191184), Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells (PubMed:23213458), During the embryo preimplantation, controls different aspects of M phase (PubMed:15988037), During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (PubMed:25168238)


This is Zinc finger protein 445 protein, from Mouse, contains 986 amino acids, has 12 C2H2-type Zinc finger.

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation, Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440), Acts together with ZFP57, but ZFP57 plays the predominant role in imprinting maintenance, In contrast, ZNF445 seems to be the major factor in human early embryonic imprinting maintenance (PubMed:30602440)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Cell surface glycoprotein MUC18 protein, from Mouse, contains 648 amino acids, has 2 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue, Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread, Could be an adhesion molecule active in neural crest cells during embryonic development, Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity)


This is Vacuolar protein sorting-associated protein 18 homolog protein, from Mouse, contains 973 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways, Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion, The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes, The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity), Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:14517315, PubMed:22854957), Involved in dendrite development of Pukinje cells (PubMed:22699122)


This is Zinc finger HIT domain-containing protein 1 protein, from Mouse, contains 154 amino acids, has 1 HIT-type Zinc finger.

HIT-type

Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A,Z into the genome to regulate gene expression (PubMed:29138493, PubMed:30842416, PubMed:32694618, PubMed:33913477, PubMed:35413238, PubMed:35167494), Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (PubMed:29138493), Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone variant H2AZ1 to chromatin and induces muscle-specific gene expression (By similarity), Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (PubMed:32694618), Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (PubMed:30842416), Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (PubMed:30842416), Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (PubMed:35413238), Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (PubMed:35167494), During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (PubMed:33913477), In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (By similarity), Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (By similarity), Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (By similarity), Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (PubMed:19501046), Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (PubMed:35472217), Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (By similarity)


This is Immunoglobulin superfamily member 8 protein, from Mouse, contains 611 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function, May regulate proliferation and differentiation of keratinocytes, May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers, May also play a role on integrin-dependent morphology and motility functions, May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain


This is CXADR-like membrane protein protein, from Mouse, contains 373 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

May be involved in the cell-cell adhesion, May play a role in adipocyte differentiation and development of obesity, Is required for normal small intestine development (By similarity)


This is Speckle targeted PIP5K1A-regulated poly(A) polymerase protein, from Mouse, contains 869 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs, Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1, In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs, In addition to adenylyltransferase activity, also has uridylyltransferase activity, However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase, Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA, Not involved in replication-dependent histone mRNA degradation

Belongs to the DNA polymerase type-B-like family


This is Probable E3 ubiquitin-protein ligase DTX2 protein, from Mouse, contains 619 amino acids, has 1 RING-type Zinc finger.

RING-type

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context, Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1, Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity)


This is Cell adhesion molecule 4 protein, from Mouse, contains 388 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Involved in the cell-cell adhesion, Has calcium- and magnesium-independent cell-cell adhesion activity, May have tumor-suppressor activity


This is E3 ubiquitin-protein ligase SIAH2 protein, from Rat, contains 325 amino acids, has 1 RING-type Zinc finger, has 1 SIAH-type Zinc finger.

RING-type

SIAH-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11786535), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11786535), Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (By similarity), Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (By similarity), Promotes monoubiquitination of SNCA (By similarity), Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11786535), It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (By similarity), Has some overlapping function with SIAH1 (By similarity), Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (By similarity), Regulates cellular clock function via ubiquitination of circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation, Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (By similarity), Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity), Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (By similarity)

Belongs to the SINA (Seven in absentia) family


This is NFAT activation molecule 1 protein, from Mouse, contains 264 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters, Activates the transcription of IL-13 and TNF-alpha promoters (By similarity), May be involved in the regulation of B-cell, but not T-cell, development


This is E3 ubiquitin-protein ligase MIB2 protein, from Mouse, contains 973 amino acids, has 1 ZZ-type Zinc finger, has 2 RING-type Zinc finger.

ZZ-type

RING-type

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins, Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors


This is N-lysine methyltransferase SMYD2 protein, from Mouse, contains 433 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1, Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo, The activity requires interaction with HSP90alpha, Shows even higher methyltransferase activity on p53/TP53, Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53, Monomethylates RB1 at 'Lys-860'


This is Zinc finger MYND domain-containing protein 11 protein, from Mouse, contains 602 amino acids, has 1 PHD-type Zinc finger, has 1 MYND-type Zinc finger.

PHD-type

MYND-type

Chromatin reader that specifically recognizes and binds histone H3,3 trimethylated at 'Lys-36' (H3,3K36me3) and regulates RNA polymerase II elongation, Does not bind other histone H3 subtypes (H3,1 or H3,2), Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage (PubMed:24590075), Binds non-specifically to dsDNA (By similarity), Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth (PubMed:24590075)


This is Ubiquitin carboxyl-terminal hydrolase 33 protein, from Mouse, contains 909 amino acids, has 1 UBP-type Zinc finger.

UBP-type

Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling, Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate, Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling, Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1, Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2), Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2, Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2, This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins, Deubiquitinates DIO2, thereby regulating thyroid hormone regulation, Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Belongs to the peptidase C19 family, USP20/USP33 subfamily


This is Optineurin protein, from Rat, contains 585 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8, Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation, Negatively regulates the induction of IFNB in response to RNA virus infection, Plays a neuroprotective role in the eye and optic nerve, Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment, Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52


This is Cell adhesion molecule 1 protein, from Mouse, contains 456 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12202822, PubMed:12799182, PubMed:12826663), Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (PubMed:12826663), Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952), In mast cells, may mediate attachment to and promote communication with nerves (By similarity), CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:15158462, PubMed:16605125), By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (PubMed:19752223), Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959), Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959), Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (PubMed:12202822, PubMed:23209303), May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (PubMed:15707673), May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (PubMed:12606335, PubMed:16612000)


This is Glycine-rich RNA-binding protein RZ1C protein, from Mouse-ear cress, contains 310 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Binds RNA and DNA sequences non-specifically, May be involved in tolerance to cold stress


This is E3 ubiquitin-protein ligase RGLG3 protein, from Mouse-ear cress, contains 367 amino acids, has 1 RING-type Zinc finger.

RING-type

Possesses E3 ubiquitin-protein ligase in vitro, Acts as upstream modulator of jasmonate (JA) signaling in response to various stimuli, such as JA-inhibited root growth, JA-inductive gene expression, coronatine-mediated pathogen susceptibility, wound-stimulated expression of JA-responsive genes and wound-induced JA biosynthesis (PubMed:22898498), Controls fumonisin B1 (FB1)-triggered programmed cell death (PCD) by modulating the JA signaling pathway, May mediate salicylic acid (SA) suppression of JA signaling in FB1-induced responses (PubMed:25788731), May mediate the formation of 'Lys-48'-linked multiubiquitin chains, Mediates the polyubiquitination and subsequent proteasomal degradation of the target protein GRXS17 (PubMed:27497447)


This is E3 ubiquitin-protein ligase AIP2 protein, from Mouse-ear cress, contains 310 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of abscisic acid (ABA) signaling, Mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ABI3


This is Protein BREAST CANCER SUSCEPTIBILITY 1 homolog protein, from Mouse-ear cress, contains 941 amino acids, has 1 RING-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type; degenerate Zinc finger.

RING-type

C2HC pre-PHD-type

PHD-type; degenerate

Plays a role in DNA repair and in cell-cycle control, Required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR)