This is E3 ubiquitin-protein ligase MARCHF6 protein, from Human, contains 910 amino acids, has 1 RING-CH-type Zinc finger.

RING-CH-type

E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (PubMed:15673284), Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899), Promotes ubiquitination of SQLE, leading to its degradation (PubMed:24449766), E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates, May cooperate with UBE2G1 (PubMed:15673284)


This is Zinc finger protein ZIC 3 protein, from Human, contains 467 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Acts as transcriptional activator, Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification, Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'

Belongs to the GLI C2H2-type zinc-finger protein family


This is Myelin protein zero-like protein 2 protein, from Human, contains 215 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is Fas apoptotic inhibitory molecule 3 protein, from Human, contains 390 amino acids, has 1 Ig-like Immunoglobulin domain.

Ig-like

May play a role in the immune system processes, Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL, Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream, May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation


This is Protein arginine N-methyltransferase 3 protein, from Human, contains 531 amino acids, has 1 C2H2-type Zinc finger.

Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (Probable), May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (PubMed:33495566)

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family


This is Peroxisome biogenesis factor 10 protein, from Human, contains 326 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:24662292), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is E3 ubiquitin-protein ligase TRIM13 protein, from Human, contains 407 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD), This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins, Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386), Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway, Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809), Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585), In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375)


This is DNA/RNA-binding protein KIN17 protein, from Human, contains 393 amino acids, has 1 C2H2-type Zinc finger.

Involved in DNA replication and the cellular response to DNA damage, May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes, May play a role in illegitimate recombination and regulation of gene expression, May participate in mRNA processing, Binds, in vitro, to double-stranded DNA, Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity), Binds via its C-terminal domain to RNA in vitro


This is DnaJ homolog subfamily A member 2 protein, from Human, contains 412 amino acids, has 1 CR-type Zinc finger.

CR-type

Co-chaperone of Hsc70, Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877)


This is Sodium channel subunit beta-2 protein, from Human, contains 215 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel, The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli, Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity)

Belongs to the sodium channel auxiliary subunit SCN2B (TC 8,A,17) family


This is Dystrobrevin beta protein, from Human, contains 627 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity), May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470), May be required for proper maturation and function of a subset of inhibitory synapses (By similarity)

Belongs to the dystrophin family, Dystrobrevin subfamily


This is Thy-1 membrane glycoprotein protein, from Rhesus macaque, contains 161 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain


This is Wilms tumor protein homolog protein, from Pig, contains 449 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor that plays an important role in cellular development and cell survival, Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3', Regulates the expression of numerous target genes, including EPO, Plays an essential role for development of the urogenital system, It has a tumor suppressor as well as an oncogenic role in tumor formation, Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors, Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing, Isoform 1 has lower affinity for DNA, and can bind RNA

Belongs to the EGR C2H2-type zinc-finger protein family


This is Peroxisome proliferator-activated receptor gamma protein, from Pig, contains 504 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase, It therefore controls the peroxisomal beta-oxidation pathway of fatty acids, Key regulator of adipocyte differentiation and glucose homeostasis, ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer, Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses, Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is E3 ubiquitin-protein ligase RMA1 protein, from Mouse-ear cress, contains 249 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of aquaporin PIP2-1, Forms a ubiquitin ligase complex in cooperation with the E2 enzymes UCB8/UCB10


This is Zinc-finger homeodomain protein 3 protein, from Mouse-ear cress, contains 310 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger.

ZF-HD dimerization-type; degenerate


This is Protein PHOTOSYSTEM I ASSEMBLY 2, chloroplastic protein, from Mouse-ear cress, contains 186 amino acids, has 1 CR-type Zinc finger.

CR-type

Involved in female gametophyte development, Required for embryo sac development (PubMed:15634699), Nuclear genome-encoded factor required for the accumulation of photosystem I (PSI) during plant development (PubMed:25228689), Required for light acclimation and chloroplast development (PubMed:27047527)


This is Lysine-specific demethylase JMJ15 protein, from Mouse-ear cress, contains 806 amino acids, has 1 C5HC2 Zinc finger.

Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a specific activity for H3K4me3 (PubMed:22555401), No activity on H3K4me2, H3K4me1, H3K9me3/2, H3K27me3/2 and H3K36me3/2 (PubMed:22555401), Involved in the control of flowering time by demethylating H3K4me3 at the FLC locus and repressing its expression (PubMed:22555401), The repression of FLC level and reduction in H3K4me3 at the FLC locus results in induction of the flowering activator FT, which is a downstream target of FLC (PubMed:22555401), Promotes salt tolerance by down-regulating the expression of several transcriptions factors involved in stress responses via H3K4me3 and H3K4me2 demethylation (PubMed:25009544)

Belongs to the JARID1 histone demethylase family


This is E3 ubiquitin-protein ligase ATL9 protein, from Mouse-ear cress, contains 378 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro, May be involved in the early steps of the plant defense signaling pathway

Belongs to the RING-type zinc finger family, ATL subfamily


This is Cold shock protein 1 protein, from Mouse-ear cress, contains 299 amino acids, has 7 CCHC-type Zinc finger.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

Chaperone that binds to RNA, single- (ssDNA) and double-stranded (dsDNA) DNA, and unwinds nucleic acid duplex, Exhibits a DNA melting activity, May be involved in cold resistance, Prevents seed germination under dehydration or salt stress conditions

Belongs to the cold shock protein (CSP) family


This is Zinc finger protein 143 protein, from Mouse, contains 638 amino acids, has 7 C2H2-type Zinc finger.

Transcriptional activator, Activates the gene for selenocysteine tRNA (tRNAsec), Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters, Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity)


This is Zinc finger protein Gfi-1b protein, from Mouse, contains 330 amino acids, has 6 C2H2-type Zinc finger.

Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages, Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation, Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways, Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate, Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells, Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells, Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction, Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression, Alters histone methylation by recruiting histone methyltransferase to target genes promoters, Plays a role in heterochromatin formation


This is Myelin protein zero-like protein 2 protein, from Mouse, contains 215 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type


This is E3 SUMO-protein ligase PIAS3 protein, from Rat, contains 628 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway, The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context, Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation, Sumoylates CCAR2 which promotes its interaction with SIRT1, Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity)


This is E3 ubiquitin-protein ligase LNX protein, from Mouse, contains 728 amino acids, has 1 RING-type Zinc finger.

RING-type

Isoform 2 provides an endocytic scaffold for IGSF5/JAM4


This is Tripartite motif-containing protein 3 protein, from Rat, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:20352094), In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation, Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity), Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (PubMed:20352094), Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity), Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A, Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3, In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity)


This is Butyrophilin-like protein 2 protein, from Mouse, contains 454 amino acids, has 4 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Negative regulator of T-cell proliferation

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Protein CBFA2T2 protein, from Mouse, contains 594 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes, Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency, Involved in primordial germ cell (PCG) formation (PubMed:27281218), Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity), Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863), Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606), Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765)


This is RING finger protein 112 protein, from Rat, contains 631 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development, During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins, Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage, Exhibits GTPase and E3 ubiquitin-protein ligase activities, Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density

Belongs to the TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily


This is Four and a half LIM domains protein 2 protein, from Mouse, contains 279 amino acids, has 1 C4-type Zinc finger.

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation, Negatively regulates the transcriptional repressor E4F1 and may function in cell growth, Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity), Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:22851699)


This is BRCA1-associated RING domain protein 1 protein, from Mouse, contains 765 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase, The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability, Plays a central role in the control of the cell cycle in response to DNA damage, Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function, Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage


This is Protein arginine N-methyltransferase 3 protein, from Rat, contains 528 amino acids, has 1 C2H2-type Zinc finger.

Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:9642256, PubMed:15334060, PubMed:10899106), May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (By similarity)


This is Transcription factor Sp3 protein, from Mouse, contains 783 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications, Binds to GT and GC boxes promoter elements, Competes with SP1 for the GC-box promoters, Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Mucosal addressin cell adhesion molecule 1 protein, from Rat, contains 394 amino acids, has 3 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Ig-like

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria, It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes (By similarity)


This is Polymeric immunoglobulin receptor protein, from Mouse, contains 771 amino acids, has 1 Ig-like V-type 1; required for binding to polymeric IgA and IgM Immunoglobulin domain, has 4 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Ig-like V-type

Ig-like V-type

Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens, On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells


This is E3 ubiquitin-protein ligase Midline-1 protein, from Mouse, contains 680 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger.

RING-type

B box-type

B box-type

Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination


This is Dystrobrevin beta protein, from Mouse, contains 659 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (PubMed:11585924), May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:20530487), May be required for proper maturation and function of a subset of inhibitory synapses (PubMed:16540561)


This is RING finger protein Z protein, from LASV, contains 99 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Plays a crucial role in virion assembly and budding, Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L, Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP, Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway, The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z, Also selectively represses protein production by associating with host eIF4E

Belongs to the arenaviridae Z protein family


This is Glucocorticoid receptor protein, from Bastard halibut, contains 807 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Receptor for glucocorticoids (GC), Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors, Affects inflammatory responses, cellular proliferation and differentiation in target tissues, Involved in chromatin remodeling, Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay, Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth, Mediates glucocorticoid-induced apoptosis, Promotes accurate chromosome segregation during mitosis, May act as a tumor suppressor, May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Zinc finger protein ZIC 1 protein, from African clawed frog, contains 443 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes, Has multiple key roles in the regulation of neural induction and neurogenesis: acts as a neural competence factor, sensitizing the presumptive neuroectoderm to respond to subsequent neuralizing signals, Promotes both preplacodal cell fates and neural crest cell fates, two of the cell populations that arise from the neural plate border, Cooperates with pax3 in concert with wnt signaling to determine neural crest fate, Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2, May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'


This is Branchpoint-bridging protein protein, from Fission yeast, contains 587 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Necessary for the splicing of pre-mRNA, The BPB1(SF1)-u2af59-u2af23 complex has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns


This is E3 ubiquitin-protein ligase brl2 protein, from Fission yeast, contains 680 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation


This is Chromatin modification-related protein png2 protein, from Fission yeast, contains 305 amino acids, has 1 PHD-type Zinc finger.

PHD-type

Component of the clr6 histone deacetylase complex I' responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Has a role in silencing of mating type genes


This is Mitochondrial protein import protein mas5 protein, from Fission yeast, contains 407 amino acids, has 1 CR-type Zinc finger.

CR-type

Probably involved in mitochondrial protein import (By similarity), Plays a role in microtubule cytoskeleton organization


This is ERAD-associated E3 ubiquitin-protein ligase hrd1 protein, from Fission yeast, contains 677 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation, Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD), Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity), Together with ubc7, required for the degradation of the transcription factor sre1 precursor in the absence of its binding partner scp1


This is DNA polymerase kappa protein, from Fission yeast, contains 547 amino acids, has 1 UBZ4-type Zinc finger.

DNA polymerase specifically involved in DNA repair, Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls, Has a role in meiosis


This is Low affinity immunoglobulin gamma Fc region receptor III-B protein, from Human, contains 233 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Receptor for the Fc region of immunoglobulins gamma, Low affinity receptor, Binds complexed or aggregated IgG and also monomeric IgG, Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis, May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils


This is Leukocyte immunoglobulin-like receptor subfamily A member 1 protein, from Human, contains 489 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May act as receptor for class I MHC antigens


This is Leukocyte immunoglobulin-like receptor subfamily B member 3 protein, from Human, contains 631 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May act as receptor for class I MHC antigens, Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor, Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)


This is Leukocyte immunoglobulin-like receptor subfamily B member 5 protein, from Human, contains 590 amino acids, has 4 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type


This is Protein CBFA2T3 protein, from Human, contains 653 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486)


This is Microfibrillar-associated protein 3-like protein, from Human, contains 409 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

May participate in the nuclear signaling of EGFR and MAPK1/ERK2, May a have a role in metastasis


This is ICOS ligand protein, from Human, contains 302 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Ligand for the T-cell-specific cell surface receptor ICOS, Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells, Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity)


This is Zinc finger CCCH domain-containing protein 11A protein, from Human, contains 810 amino acids, has 3 C3H1-type Zinc finger.

(Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1, Required for efficient viral mRNA Export


This is Zinc finger protein ZPR1 protein, from Human, contains 459 amino acids, has 2 C4-type Zinc finger.

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus, It is involved in the positive regulation of cell cycle progression (PubMed:29851065), Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies, Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons, Plays a role in the splicing of cellular pre-mRNAs, May be involved in H(2)O(2)-induced neuronal cell death


This is Semaphorin-7A protein, from Human, contains 666 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses, Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3, Promotes production of pro-inflammatory cytokines by monocytes and macrophages, Plays an important role in modulating inflammation and T-cell-mediated immune responses, Promotes axon growth in the embryonic olfactory bulb, Promotes attachment, spreading and dendrite outgrowth in melanocytes


This is Tripartite motif-containing protein 3 protein, from Human, contains 744 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger.

RING-type

B box-type

E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity), In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation, Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity), Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity), Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity), Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003), Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999), In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999)


This is Deformed epidermal autoregulatory factor 1 homolog protein, from Human, contains 565 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene, Down-regulates transcription of these genes, Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3', Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction, When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase, Required for neural tube closure and skeletal patterning, Regulates epithelial cell proliferation and side-branching in the mammary gland, Controls the expression of peripheral tissue antigens in pancreatic lymph nodes, Isoform 1 displays greater transcriptional activity than isoform 4, Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm, Transcriptional activator of EIF4G3


This is Histone deacetylase complex subunit SAP30 protein, from Human, contains 220 amino acids, has 1 Atypical Zinc finger.

Atypical

(Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC


This is Cytokine receptor-like factor 1 protein, from Human, contains 422 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable), May also play a regulatory role in the immune system

Belongs to the type I cytokine receptor family, Type 3 subfamily


This is Nuclear receptor subfamily 1 group I member 2 protein, from Human, contains 434 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds, Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds, Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones, Response to specific ligands is species-specific, Activated by naturally occurring steroids, such as pregnenolone and progesterone, Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes


This is Transcriptional adapter 2-alpha protein, from Human, contains 443 amino acids, has 1 ZZ-type Zinc finger.

ZZ-type

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4, Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity), Binds double-stranded DNA, Binds dinucleosomes, probably at the linker region between neighboring nucleosomes, Plays a role in chromatin remodeling, May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376), May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376)


This is WW domain-binding protein 4 protein, from Human, contains 376 amino acids, has 1 Matrin-type Zinc finger.

Matrin-type

Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166), May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750)


This is PR domain zinc finger protein 1 protein, from Human, contains 825 amino acids, has 4 C2H2-type Zinc finger.

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs, Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity), Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123), Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569), Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity), Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Ret finger protein-like 1 protein, from Human, contains 317 amino acids, has 1 RING-type Zinc finger.

RING-type

Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase


This is Ret finger protein-like 2 protein, from Human, contains 378 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate


This is Ret finger protein-like 3 protein, from Human, contains 317 amino acids, has 1 RING-type Zinc finger.

RING-type

(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex


This is Arf-GAP with dual PH domain-containing protein 1 protein, from Human, contains 374 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein for the ADP ribosylation factor family (Probable), Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4)


This is Zinc finger MYND domain-containing protein 10 protein, from Human, contains 440 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471), Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity), May act by indirectly regulating transcription of dynein proteins (By similarity)


This is Krueppel-like factor 7 protein, from Human, contains 302 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional factor (PubMed:9774444, PubMed:16339272), Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity), Represses the corneal epithelium differentiation (PubMed:28916725), Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272), Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Carcinoembryonic antigen-related cell adhesion molecule 4 protein, from Human, contains 244 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles

Belongs to the immunoglobulin superfamily, CEA family


This is Matrix metalloproteinase-23 protein, from Human, contains 390 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease, May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity)


This is E3 SUMO-protein ligase PIAS1 protein, from Human, contains 651 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

(Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325), The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325)


This is E3 SUMO-protein ligase PIAS2 protein, from Human, contains 621 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway, The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied, However, it seems to be mostly involved in gene silencing, Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity, Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation, Isoform PIAS2-alpha promotes PARK7 sumoylation, Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha, Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'


This is Natural cytotoxicity triggering receptor 1 protein, from Human, contains 304 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis

Belongs to the natural cytotoxicity receptor (NCR) family


This is E3 ubiquitin-protein ligase NEURL1 protein, from Human, contains 574 amino acids, has 1 RING-type Zinc finger.

RING-type

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory, Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3, Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2, Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway, Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway


This is E3 ubiquitin-protein ligase RNF8 protein, from Human, contains 485 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites, Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF), Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites, Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair, H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates, Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA, Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases, For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains, Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5, Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979), Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta, In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (PubMed:23233665), In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation, Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase, Required in the testis, where it plays a role in the replacement of histones during spermatogenesis, At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis, Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair, May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis, May play a role in the regulation of RXRA-mediated transcriptional activity, Not involved in RXRA ubiquitination by UBE2E2 (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979)


This is AN1-type zinc finger protein 5 protein, from Human, contains 213 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger.

Involved in protein degradation via the ubiquitin-proteasome system, May act by anchoring ubiquitinated proteins to the proteasome, Plays a role in ubiquitin-mediated protein degradation during muscle atrophy, Plays a role in the regulation of NF-kappa-B activation and apoptosis, Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA, Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner, Overexpression sensitizes cells to TNF-induced apoptosis, Is a potent inhibitory factor for osteoclast differentiation


This is Pleckstrin homology domain-containing family F member 1 homolog protein, from Fruit fly, contains 316 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Functions in the regulation of endosome morphology and late endosome formation, Has a role in controlling trafficking from early to late endosomes and from late endosomes to lysosomes, Important for localization of Gdi to the endosomal membranes, May function in controlling the activity of multiple regulators in the endocytic pathway, perhaps by positively controlling those involved in the early steps of endocytosis such as Rab5 and hrs, and negative regulating those involved in the late stages of endocytosis like car and VhaSFD


This is RING finger protein vilya protein, from Fruit fly, contains 237 amino acids, has 1 RING-type Zinc finger.

RING-type

Required for the formation of DNA double-strand breaks during meiosis together with narya and nenya


This is Potential E3 ubiquitin-protein ligase ariadne-2 protein, from Fruit fly, contains 509 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates

Belongs to the RBR family, Ariadne subfamily


This is Transcription factor Ken protein, from Fruit fly, contains 601 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor required for terminalia development, Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles


This is Extra-large guanine nucleotide-binding protein 1 protein, from Mouse-ear cress, contains 888 amino acids, has 1 RING-type; degenerate Zinc finger.

RING-type; degenerate

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity), Binds GTP with specificity, Plays a role in the root morphogenesis by regulation of the cell proliferation

Belongs to the G-alpha family, XLG subfamily


This is Dof zinc finger protein DOF2.4 protein, from Mouse-ear cress, contains 330 amino acids, has 1 Dof-type Zinc finger.

Dof-type

Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity), Probably involved in early processes for vascular development (PubMed:17583520), The PEAR proteins (e,g, DOF2,4, DOF5,1, DOF3,2, DOF1,1, DOF5,6 and DOF5,3) activate gene expression that promotes radial growth of protophloem sieve elements, Triggers the transcription of HD-ZIP III genes, especially in the central domain of vascular tissue (PubMed:30626969)


This is BRAP2 RING ZnF UBP domain-containing protein 2 protein, from Mouse-ear cress, contains 479 amino acids, has 1 RING-type; atypical Zinc finger, has 1 UBP-type; degenerate Zinc finger.

RING-type; atypical

UBP-type; degenerate

RING-type ubiquitin E3 ligase that binds ubiquitin and is required for seed germination and post-germination growth


This is Serine/arginine-rich splicing factor RSZ22 protein, from Mouse-ear cress, contains 200 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Sequence-specific RNA-binding protein probably involved in pre-mRNA splicing, In vitro, can complement efficiently splicing-deficient mammalian SRSF7-depleted HeLa cell extract

Belongs to the splicing factor SR family, RSZ subfamily


This is Serine/arginine-rich splicing factor RSZ21 protein, from Mouse-ear cress, contains 187 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Probably involved in intron recognition and spliceosome assembly


This is Plant-specific TFIIB-related protein PTF2 protein, from Mouse-ear cress, contains 527 amino acids, has 1 TFIIB-type Zinc finger.

TFIIB-type

Plant-specific TFIIB-related protein that plays important roles in pollen germination and embryogenesis, possibly by regulating gene expression through interaction with TBP2 and the subunits of RNA polymerases, Binds double-stranded DNA in vitro


This is E3 ubiquitin-protein ligase BOI protein, from Mouse-ear cress, contains 304 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase involved in the regulation of pathogen and abiotic stress responses by facilitating degradation of MYB108/BOI, Attenuates cell death by preventing caspase activation, Has no effect on the stability of the DELLA proteins, Not regulated by MYB108/BOI


This is ADP-ribosylation factor GTPase-activating protein AGD10 protein, from Mouse-ear cress, contains 395 amino acids, has 1 C4-type Zinc finger.

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF), Activates ARF1 and ARF2, Required for female gametophyte development, Involved in root hair and pollen tube growth


This is E3 ubiquitin-protein ligase RFI2 protein, from Mouse-ear cress, contains 358 amino acids, has 1 RING-type; atypical Zinc finger.

RING-type; atypical

Mediates phytochrome (phyA and phyB)-controlled seedling deetiolation responses such as hypocotyl elongation in response to red and far-red light (PubMed:16709197, PubMed:16384903), Required for light-induced expression of LHCB3 and CHALCONE SYNTHASE (CHS) (PubMed:16384903), Regulates negatively CONSTANS (CO) and FLOWERING LOCUS T (FT) expression and photoperiodic flowering (PubMed:16709197)


This is Matrix metalloproteinase-23 protein, from Rat, contains 391 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease, May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum


This is Peroxisome proliferator-activated receptor gamma protein, from Rat, contains 505 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids, Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase, It therefore controls the peroxisomal beta-oxidation pathway of fatty acids, Key regulator of adipocyte differentiation and glucose homeostasis, ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer, Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses, Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is B-cell CLL/lymphoma 6 member B protein protein, from Mouse, contains 474 amino acids, has 5 C2H2-type Zinc finger.

Acts as a sequence-specific transcriptional repressor in association with BCL6, Necessary for activation of naive T-cells to antigenic stimulation, May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6


This is DBIRD complex subunit ZNF326 protein, from Mouse, contains 580 amino acids, has 2 C2H2 AKAP95-type Zinc finger.

C2H2 AKAP95-type

C2H2 AKAP95-type

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity), May also play a role in neuronal differentiation, Able to bind DNA and activate expression in vitro


This is FYVE, RhoGEF and PH domain-containing protein 4 protein, from Rat, contains 766 amino acids, has 1 FYVE-type Zinc finger.

FYVE-type

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP, Plays a role in regulating the actin cytoskeleton and cell shape, Activates MAPK8


This is Deformed epidermal autoregulatory factor 1 homolog protein, from Rat, contains 565 amino acids, has 1 MYND-type Zinc finger.

MYND-type

Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene, Down-regulates transcription of these genes, Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3', Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction, When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase, Regulates epithelial cell proliferation and side-branching in the mammary gland, Required for neural tube closure and skeletal patterning, Controls the expression of peripheral tissue antigens in pancreatic lymph nodes, Transcriptional activator of EIF4G3, May also involved in behavior (By similarity)


This is Ciliary neurotrophic factor receptor subunit alpha protein, from Mouse, contains 372 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Binds to CNTF, The alpha subunit provides the receptor specificity (By similarity)


This is DNA (cytosine-5)-methyltransferase 3A protein, from Mouse, contains 908 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477), DNA methylation is coordinated with methylation of histones (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477), It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477), May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (PubMed:18823905), Plays a role in paternal and maternal imprinting (PubMed:15215868), Required for methylation of most imprinted loci in germ cells (PubMed:15215868), Acts as a transcriptional corepressor for ZBTB18 (PubMed:11350943), Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (PubMed:20547484), Can actively repress transcription through the recruitment of HDAC activity (PubMed:11350943), Also has weak auto-methylation activity on Cys-706 in absence of DNA (PubMed:21481189)

Belongs to the class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family


This is DNA (cytosine-5)-methyltransferase 3B protein, from Mouse, contains 859 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger.

GATA-type; atypical

PHD-type; atypical

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development, DNA methylation is coordinated with methylation of histones, May preferentially methylates nucleosomal DNA within the nucleosome core region, May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation, Seems to be involved in gene silencing, In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9, Functions as a transcriptional corepressor by associating with ZHX1 (By similarity), Required for DUX4 silencing in somatic cells (By similarity)


This is NF-kappa-B essential modulator protein, from Mouse, contains 412 amino acids, has 1 CCHC NOA-type Zinc finger.

CCHC NOA-type

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:9927690), Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways, Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin, Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity, Essential for viral activation of IRF3, Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity)


This is Histone deacetylase complex subunit SAP30 protein, from Mouse, contains 220 amino acids, has 1 Atypical Zinc finger.

Atypical

Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes, Capable of transcription repression by N-CoR, Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones


This is Semaphorin-3F protein, from Mouse, contains 785 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type


This is Diacylglycerol kinase alpha protein, from Mouse, contains 730 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids, Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes, Also plays an important role in the biosynthesis of complex lipids, Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group, Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol

Belongs to the eukaryotic diacylglycerol kinase family


This is Matrix metalloproteinase-23 protein, from Mouse, contains 391 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Protease, May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity)


This is Embigin protein, from Rat, contains 328 amino acids, has 2 Ig-like Immunoglobulin domain.

Ig-like

Ig-like

Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions, Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology, Delays the retraction of terminal sprouts following re-innervation of denervated endplates (By similarity), Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane


This is Junctional adhesion molecule A protein, from Mouse, contains 300 amino acids, has 2 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Ig-like V-type

Seems to play a role in epithelial tight junction formation, Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11447115), The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (PubMed:11447115), Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (PubMed:9660867), Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (By similarity), Involved in platelet activation (By similarity)

Belongs to the immunoglobulin superfamily


This is E3 ubiquitin-protein ligase RNF4 protein, from Rat, contains 194 amino acids, has 1 RING-type Zinc finger.

RING-type

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:14987998, PubMed:18408734, PubMed:15707587), Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:15707587, PubMed:20943951), Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (By similarity), Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (By similarity), Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:11319220, PubMed:9710597), Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (By similarity)


This is CD160 antigen protein, from Mouse, contains 185 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions


This is AN1-type zinc finger protein 5 protein, from Mouse, contains 213 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger.

Involved in protein degradation via the ubiquitin-proteasome system, May act by anchoring ubiquitinated proteins to the proteasome, Plays a role in ubiquitin-mediated protein degradation during muscle atrophy, Plays a role in the regulation of NF-kappa-B activation and apoptosis, Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA, Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner, Overexpression sensitizes cells to TNF-induced apoptosis, Is a potent inhibitory factor for osteoclast differentiation


This is E3 SUMO-protein ligase PIAS1 protein, from Mouse, contains 651 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway, In vitro, binds A/T-rich DNA (By similarity), The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context, Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation, PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation, Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation, Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474)


This is Zinc finger and BTB domain-containing protein 7A protein, from Mouse, contains 569 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:15337766, PubMed:15662416, PubMed:17495164, PubMed:26816381, PubMed:29813070), Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:15337766, PubMed:15662416, PubMed:26816381, PubMed:29813070), Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (By similarity), That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity), Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (PubMed:29813070), Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (By similarity), Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (By similarity), Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity), Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381), Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381), Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (PubMed:15662416), Efficiently abrogates E2F1-dependent CDKN2A transactivation (PubMed:15662416), Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (PubMed:15337766), Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (By similarity), Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity), Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (PubMed:17495164), Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (PubMed:17495164), Also regulates osteoclast differentiation (By similarity), May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (PubMed:26446488), Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (PubMed:26446488), May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity)


This is Transcription factor Sp1 protein, from Mouse, contains 784 amino acids, has 3 C2H2-type Zinc finger.

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli, Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses, Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation), Binds also the PDGFR-alpha G-box promoter, May have a role in modulating the cellular response to DNA damage, Implicated in chromatin remodeling, Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity), Positively regulates the transcription of the core clock component BMAL1 (PubMed:24030830), Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (PubMed:27918959)


This is Krueppel-like factor 10 protein, from Mouse, contains 479 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3', May play a role in the cell cycle regulation (By similarity), Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity, Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver, Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis


This is Gag polyprotein protein, from HIV-1, contains 492 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1

Belongs to the primate lentivirus group gag polyprotein family


This is Gag polyprotein protein, from HIV-1, contains 495 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Gag polyprotein protein, from HIV-1, contains 512 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Capsid-associated protein Vp91 protein, from BmNPV, contains 839 amino acids, has 1 C2HC BV-type Zinc finger.

C2HC BV-type


This is Gag polyprotein protein, from RSV-SR-B, contains 701 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type

Aspartyl protease that mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane, Cleavages take place as an ordered, step-wise cascade to yield mature proteins, This process is called maturation, Displays maximal activity during the budding process just prior to particle release from the cell


This is Gag polyprotein protein, from HIV-1, contains 500 amino acids, has 2 CCHC-type Zinc finger.

CCHC-type

CCHC-type


This is Histone acetyltransferase mst1 protein, from Fission yeast, contains 463 amino acids, has 1 C2HC MYST-type Zinc finger.

C2HC MYST-type

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A,Z (PubMed:16199868), Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity), The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation (PubMed:18505873, PubMed:33723569), The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (PubMed:33723569), Recruitment to promoters depends on H3K4me (By similarity), Also acetylates non-histone proteins (By similarity), In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (PubMed:29192674)


This is E3 SUMO-protein ligase pli1 protein, from Fission yeast, contains 727 amino acids, has 1 SP-RING-type Zinc finger.

SP-RING-type

Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins, Involved in the maintenance of the centromere and in telomere length, Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats


This is RNA polymerase II transcription factor B subunit 3 protein, from Fission yeast, contains 318 amino acids, has 1 RING-type Zinc finger.

RING-type

Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA, TFIIH has CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity)


This is Transcription factor fil1 protein, from Fission yeast, contains 557 amino acids, has 2 GATA-type Zinc finger.

GATA-type

GATA-type

Activates genes required for amino acid biosynthesis and acts as a master transcriptional regulator during amino acid starvation (PubMed:29432178), Binds variations of the DNA sequence 5'-GAT[AC]GC-3' (PubMed:29432178)


This is Metastasis-associated protein MTA2 protein, from Human, contains 668 amino acids, has 1 GATA-type; atypical Zinc finger.

GATA-type; atypical

May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666)


This is Serine/threonine-protein kinase D3 protein, from Human, contains 890 amino acids, has 2 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Phorbol-ester/DAG-type

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC, Involved in resistance to oxidative stress (By similarity)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily


This is PHD finger protein 14 protein, from Human, contains 948 amino acids, has 4 PHD-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger.

PHD-type

C2HC pre-PHD-type

PHD-type

PHD-type

PHD-type

Histone-binding protein (PubMed:23688586), Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity), Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity), Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity)


This is RING finger protein 37 protein, from Human, contains 541 amino acids, has 1 RING-type Zinc finger.

RING-type

May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates


This is E3 ubiquitin-protein ligase TRIM37 protein, from Human, contains 964 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 B box-type Zinc finger.

RING-type; degenerate

B box-type

E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972), Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972), Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042), Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525), Has anti-HIV activity (PubMed:24317724)


This is Zinc finger protein 202 protein, from Human, contains 648 amino acids, has 8 C2H2-type Zinc finger.

Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism, Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease


This is Zinc finger protein-like 1 protein, from Human, contains 310 amino acids, has 1 B box-type; degenerate Zinc finger, has 1 RING-type; degenerate Zinc finger.

B box-type; degenerate

RING-type; degenerate

Required for cis-Golgi integrity and efficient ER to Golgi transport, Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130

Golgi apparatus, cis-Golgi network membrane


This is Netrin receptor UNC5C protein, from Human, contains 931 amino acids, has 1 Ig-like Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like

Ig-like C2-type

Receptor for netrin required for axon guidance (By similarity), Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity), NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977), Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity), Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity), Also involved in corticospinal tract axon guidance independently of DCC (By similarity), Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977), It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity)


This is Transcriptional repressor RHIT protein, from Human, contains 554 amino acids, has 8 C2H2-type Zinc finger.

Transcriptional repressor involved in regulating MPV17L expression (PubMed:22306510), By regulating MPV17L expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade (PubMed:22306510)


This is Zinc finger Ran-binding domain-containing protein 2 protein, from Human, contains 330 amino acids, has 2 RanBP2-type Zinc finger.

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts, May interfere with constitutive 5'-splice site selection


This is Histone acetyltransferase KAT7 protein, from Human, contains 611 amino acids, has 1 CCHHC-type Zinc finger, has 1 C2HC MYST-type Zinc finger.

CCHHC-type

C2HC MYST-type

Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282), Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282)


This is Interleukin-18 receptor accessory protein protein, from Human, contains 599 amino acids, has 2 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Ig-like C2-type

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532), May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable)

Belongs to the interleukin-1 receptor family


This is RAS guanyl-releasing protein 1 protein, from Human, contains 797 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger.

Phorbol-ester/DAG-type

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103), Activates the Erk/MAP kinase cascade (PubMed:15899849), Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103), Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860), Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses, May also function in differentiation of other cell types (PubMed:12845332)


This is RasGAP-activating-like protein 1 protein, from Human, contains 804 amino acids, has 1 Btk-type Zinc finger.

Btk-type

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798), Plays a role in dendrite formation by melanocytes (PubMed:23999003)


This is Myelin protein zero-like protein 1 protein, from Human, contains 269 amino acids, has 1 Ig-like V-type Immunoglobulin domain.

Ig-like V-type

Cell surface receptor, which is involved in signal transduction processes, Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2, Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases, Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA, Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility


This is Tripartite motif-containing protein 16 protein, from Human, contains 564 amino acids, has 2 B box-type Zinc finger.

B box-type

B box-type

E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages, Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2, Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B, In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage


This is Zinc finger and BTB domain-containing protein 7A protein, from Human, contains 584 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381), Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381), Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493), That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493), Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity), Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059), Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024), Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024), Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381), Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381), Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity), Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity), Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity), Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326), Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838), Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity), Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity), Also regulates osteoclast differentiation (By similarity), May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity), Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity), May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149)


This is E3 ubiquitin-protein ligase ARIH2 protein, from Human, contains 493 amino acids, has 1 RING-type Zinc finger, has 1 IBR-type Zinc finger, has 1 RING-type 2; atypical Zinc finger.

RING-type

IBR-type

RING-type 2; atypical

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655), Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity), The initial ubiquitin is then elongated (By similarity), E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655), Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006), May play a role in myelopoiesis (PubMed:19340006)


This is Pre-mRNA-splicing factor SLU7 protein, from Human, contains 586 amino acids, has 1 CCHC-type Zinc finger.

CCHC-type

Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154), Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron, Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region, May be involved in the activation of proximal AG, Probably also involved in alternative splicing regulation


This is Zinc finger protein ZIC 2 protein, from Human, contains 532 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger.

C2H2-type 1; atypical

C2H2-type 2; atypical

Acts as a transcriptional activator or repressor, Plays important roles in the early stage of organogenesis of the CNS, Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets, Its transcriptional activity is repressed by MDFIC, Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline, Drives the expression of EPHB1 on ipsilaterally projecting growth cones, Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3', Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos

Belongs to the GLI C2H2-type zinc-finger protein family


This is Krueppel-like factor 8 protein, from Human, contains 359 amino acids, has 3 C2H2-type Zinc finger.

Transcriptional repressor and activator, Binds to CACCC-boxes promoter elements, Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is CCR4-NOT transcription complex subunit 4 protein, from Human, contains 575 amino acids, has 1 RING-type; degenerate Zinc finger, has 1 C3H1-type Zinc finger.

RING-type; degenerate

Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292), Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038), Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292), Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391), As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391)


This is Cleavage and polyadenylation specificity factor subunit 4 protein, from Human, contains 269 amino acids, has 5 C3H1-type Zinc finger, has 1 CCHC-type Zinc finger.

CCHC-type

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition, CPSF4 binds RNA polymers with a preference for poly(U)


This is Steroid hormone receptor ERR2 protein, from Human, contains 433 amino acids, has 2 NR C4-type Zinc finger.

NR C4-type

NR C4-type

Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity, Positively regulates ESR1 transcriptional activity upon E2 stimulation

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Cytotoxic and regulatory T-cell molecule protein, from Human, contains 393 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like V-type

Ig-like C2-type

Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity), Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952), Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity), Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity), Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity), By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity), Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity), Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity)


This is Semaphorin-4F protein, from Human, contains 770 amino acids, has 1 Ig-like C2-type Immunoglobulin domain.

Ig-like C2-type

Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity), Might also regulate differentiation of oligodendroglial precursor cells (By similarity), Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)


This is Zinc finger protein SNAI1 protein, from Human, contains 264 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger.

C2H2-type 4; atypical

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration, Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920), The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412), During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity), SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity), Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3, In addition, may also activate the CDKN2B promoter by itself

Belongs to the snail C2H2-type zinc-finger protein family