Daily Papers

Histopathological analysis is a cornerstone of cancer diagnosis, with Hematoxylin and Eosin (H&E) staining routinely acquired for every patient to visualize cell morphology and tissue architecture. On the other hand, multiplex immunofluorescence (mIF) enables more precise cell type identification via proteomic markers, but has yet to achieve widespread clinical adoption due to cost and logistical constraints. To bridge this gap, we introduce MIPHEI (Multiplex Immunofluorescence Prediction from H&E), a U-Net-inspired architecture that integrates state-of-the-art ViT foundation models as encoders to predict mIF signals from H&E images. MIPHEI targets a comprehensive panel of markers spanning nuclear content, immune lineages (T cells, B cells, myeloid), epithelium, stroma, vasculature, and proliferation. We train our model using the publicly available ORION dataset of restained H&E and mIF images from colorectal cancer tissue, and validate it on two independent datasets. MIPHEI achieves accurate cell-type classification from H&E alone, with F1 scores of 0.88 for Pan-CK, 0.57 for CD3e, 0.56 for SMA, 0.36 for CD68, and 0.30 for CD20, substantially outperforming both a state-of-the-art baseline and a random classifier for most markers. Our results indicate that our model effectively captures the complex relationships between nuclear morphologies in their tissue context, as visible in H&E images and molecular markers defining specific cell types. MIPHEI offers a promising step toward enabling cell-type-aware analysis of large-scale H&E datasets, in view of uncovering relationships between spatial cellular organization and patient outcomes.

Gene expression can be used to subtype breast cancer with improved prediction of risk of recurrence and treatment responsiveness over that obtained using routine immunohistochemistry (IHC). However, in the clinic, molecular profiling is primarily used for ER+ breast cancer, which is costly, tissue destructive, requires specialized platforms and takes several weeks to obtain a result. Deep learning algorithms can effectively extract morphological patterns in digital histopathology images to predict molecular phenotypes quickly and cost-effectively. We propose a new, computationally efficient approach called hist2RNA inspired by bulk RNA-sequencing techniques to predict the expression of 138 genes (incorporated from six commercially available molecular profiling tests), including luminal PAM50 subtype, from hematoxylin and eosin (H&E) stained whole slide images (WSIs). The training phase involves the aggregation of extracted features for each patient from a pretrained model to predict gene expression at the patient level using annotated H&E images from The Cancer Genome Atlas (TCGA, n=335). We demonstrate successful gene prediction on a held-out test set (n = 160, corr = 0.82 across patients, corr = 0.29 across genes) and perform exploratory analysis on an external tissue microarray (TMA) dataset (n = 498) with known IHC and survival information. Our model is able to predict gene expression and luminal PAM50 subtype (Luminal A versus Luminal B) on the TMA dataset with prognostic significance for overall survival in univariate analysis (c-index = 0.56, hazard ratio = 2.16 (95% CI 1.12-3.06), p < 5 x 10-3), and independent significance in multivariate analysis incorporating standard clinicopathological variables (c-index = 0.65, hazard ratio = 1.85 (95% CI 1.30-2.68), p < 5 x 10-3).

The digitization of histology slides has revolutionized pathology, providing massive datasets for cancer diagnosis and research. Contrastive self-supervised and vision-language models have been shown to effectively mine large pathology datasets to learn discriminative representations. On the other hand, generative models, capable of synthesizing realistic and diverse images, present a compelling solution to address unique problems in pathology that involve synthesizing images; overcoming annotated data scarcity, enabling privacy-preserving data sharing, and performing inherently generative tasks, such as virtual staining. We introduce PixCell, the first diffusion-based generative foundation model for histopathology. We train PixCell on PanCan-30M, a vast, diverse dataset derived from 69,184 H\&E-stained whole slide images covering various cancer types. We employ a progressive training strategy and a self-supervision-based conditioning that allows us to scale up training without any annotated data. PixCell generates diverse and high-quality images across multiple cancer types, which we find can be used in place of real data to train a self-supervised discriminative model. Synthetic images shared between institutions are subject to fewer regulatory barriers than would be the case with real clinical images. Furthermore, we showcase the ability to precisely control image generation using a small set of annotated images, which can be used for both data augmentation and educational purposes. Testing on a cell segmentation task, a mask-guided PixCell enables targeted data augmentation, improving downstream performance. Finally, we demonstrate PixCell's ability to use H\&E structural staining to infer results from molecular marker studies; we use this capability to infer IHC staining from H\&E images. Our trained models are publicly released to accelerate research in computational pathology.

Hematoxylin and Eosin (H&E) staining is widely regarded as the standard in pathology for diagnosing diseases and tracking tumor recurrence. While H&E staining shows tissue structures, it lacks the ability to reveal specific proteins that are associated with disease severity and treatment response. Immunohistochemical (IHC) stains use antibodies to highlight the expression of these proteins on their respective cell types, improving diagnostic accuracy, and assisting with drug selection for treatment. Despite their value, IHC stains require additional time and resources, limiting their utilization in some clinical settings. Recent advances in deep learning have positioned Image-to-Image (I2I) translation as a computational, cost-effective alternative for IHC. I2I generates high fidelity stain transformations digitally, potentially replacing manual staining in IHC. Diffusion models, the current state of the art in image generation and conditional tasks, are particularly well suited for virtual IHC due to their ability to produce high quality images and resilience to mode collapse. However, these models require extensive and diverse datasets (often millions of samples) to achieve a robust performance, a challenge in virtual staining applications where only thousands of samples are typically available. Inspired by the success of multitask deep learning models in scenarios with limited data, we introduce STAINDIFFUSER, a novel multitask diffusion architecture tailored to virtual staining that achieves convergence with smaller datasets. STAINDIFFUSER simultaneously trains two diffusion processes: (a) generating cell specific IHC stains from H&E images and (b) performing H&E based cell segmentation, utilizing coarse segmentation labels exclusively during training. STAINDIFFUSER generates high-quality virtual stains for two markers, outperforming over twenty I2I baselines.

Colorectal cancer is one of the most common cancers worldwide, so early pathological examination is very important. However, it is time-consuming and labor-intensive to identify the number and type of cells on H&E images in clinical. Therefore, automatic segmentation and classification task and counting the cellular composition of H&E images from pathological sections is proposed by CoNIC Challenge 2022. We proposed a multi-scale Swin transformer with HTC for this challenge, and also applied the known normalization methods to generate more augmentation data. Finally, our strategy showed that the multi-scale played a crucial role to identify different scale features and the augmentation arose the recognition of model.

Foundation models trained with self-supervised learning (SSL) on large-scale histological images have significantly accelerated the development of computational pathology. These models can serve as backbones for region-of-interest (ROI) image analysis or patch-level feature extractors in whole-slide images (WSIs) based on multiple instance learning (MIL). Existing pathology foundation models (PFMs) are typically pre-trained on Hematoxylin-Eosin (H&E) stained pathology images. However, images with special stains, such as immunohistochemistry, are also frequently used in clinical practice. PFMs pre-trained mainly on H\&E-stained images may be limited in clinical applications involving special stains. To address this issue, we propose StainNet, a specialized foundation model for special stains based on the vision transformer (ViT) architecture. StainNet adopts a self-distillation SSL approach and is trained on over 1.4 million patch images cropping from 20,231 publicly available special staining WSIs in the HISTAI database. To evaluate StainNet, we conduct experiments on an in-house slide-level liver malignancy classification task and two public ROI-level datasets to demonstrate its strong ability. We also perform few-ratio learning and retrieval evaluations, and compare StainNet with recently larger PFMs to further highlight its strengths. We have released the StainNet model weights at: https://huggingface.co/JWonderLand/StainNet.

Nuclei detection and segmentation in hematoxylin and eosin-stained (H&E) tissue images are important clinical tasks and crucial for a wide range of applications. However, it is a challenging task due to nuclei variances in staining and size, overlapping boundaries, and nuclei clustering. While convolutional neural networks have been extensively used for this task, we explore the potential of Transformer-based networks in this domain. Therefore, we introduce a new method for automated instance segmentation of cell nuclei in digitized tissue samples using a deep learning architecture based on Vision Transformer called CellViT. CellViT is trained and evaluated on the PanNuke dataset, which is one of the most challenging nuclei instance segmentation datasets, consisting of nearly 200,000 annotated Nuclei into 5 clinically important classes in 19 tissue types. We demonstrate the superiority of large-scale in-domain and out-of-domain pre-trained Vision Transformers by leveraging the recently published Segment Anything Model and a ViT-encoder pre-trained on 104 million histological image patches - achieving state-of-the-art nuclei detection and instance segmentation performance on the PanNuke dataset with a mean panoptic quality of 0.50 and an F1-detection score of 0.83. The code is publicly available at https://github.com/TIO-IKIM/CellViT

Masked image modelling (MIM) is a powerful self-supervised representation learning paradigm, whose potential has not been widely demonstrated in medical image analysis. In this work, we show the capacity of MIM to capture rich semantic representations of Haemotoxylin & Eosin (H&E)-stained images at the nuclear level. Inspired by Bidirectional Encoder representation from Image Transformers (BEiT), we split the images into smaller patches and generate corresponding discrete visual tokens. In addition to the regular grid-based patches, typically used in visual Transformers, we introduce patches of individual cell nuclei. We propose positional encoding of the irregular distribution of these structures within an image. We pre-train the model in a self-supervised manner on H&E-stained whole-slide images of diffuse large B-cell lymphoma, where cell nuclei have been segmented. The pre-training objective is to recover the original discrete visual tokens of the masked image on the one hand, and to reconstruct the visual tokens of the masked object instances on the other. Coupling these two pre-training tasks allows us to build powerful, context-aware representations of nuclei. Our model generalizes well and can be fine-tuned on downstream classification tasks, achieving improved cell classification accuracy on PanNuke dataset by more than 5% compared to current instance segmentation methods.

In computational pathology, automatic nuclei instance segmentation plays an essential role in whole slide image analysis. While many computerized approaches have been proposed for this task, supervised deep learning (DL) methods have shown superior segmentation performances compared to classical machine learning and image processing techniques. However, these models need fully annotated datasets for training which is challenging to acquire, especially in the medical domain. In this work, we release one of the biggest fully manually annotated datasets of nuclei in Hematoxylin and Eosin (H&E)-stained histological images, called NuInsSeg. This dataset contains 665 image patches with more than 30,000 manually segmented nuclei from 31 human and mouse organs. Moreover, for the first time, we provide additional ambiguous area masks for the entire dataset. These vague areas represent the parts of the images where precise and deterministic manual annotations are impossible, even for human experts. The dataset and detailed step-by-step instructions to generate related segmentation masks are publicly available at https://www.kaggle.com/datasets/ipateam/nuinsseg and https://github.com/masih4/NuInsSeg, respectively.

Background: Cancer remains one of the leading causes of morbidity and mortality worldwide. Comprehensive datasets that combine histopathological images with genetic and survival data across various tumour sites are essential for advancing computational pathology and personalised medicine. Results: We present SurGen, a dataset comprising 1,020 H&E-stained whole slide images (WSIs) from 843 colorectal cancer cases. The dataset includes detailed annotations for key genetic mutations (KRAS, NRAS, BRAF) and mismatch repair status, as well as survival data for 426 cases. To demonstrate SurGen's practical utility, we conducted a proof-of-concept machine learning experiment predicting mismatch repair status from the WSIs, achieving a test AUROC of 0.8316. These preliminary results underscore the dataset's potential to facilitate research in biomarker discovery, prognostic modelling, and advanced machine learning applications in colorectal cancer. Conclusions: SurGen offers a valuable resource for the scientific community, enabling studies that require high-quality WSIs linked with comprehensive clinical and genetic information on colorectal cancer. Our initial findings affirm the dataset's capacity to advance diagnostic precision and foster the development of personalised treatment strategies in colorectal oncology. Data available online at https://doi.org/10.6019/S-BIAD1285.

Rapid progress in computational pathology is increasingly driven by vision foundation models pretrained on vast histopathology datasets. While recent efforts have prioritized training on an ever-larger amount of patches, we take an alternative approach focused on data diversity. Our foundation model, Athena, was initialized from a pretrained model and trained on just 115 million tissue patches, several times fewer than recent histopathology foundation models. Rather than relying on patch volume or complex sampling heuristics, we maximize data diversity by randomly selecting only a moderate number of patches per whole-slide image from our diverse internal repository, which spans multiple countries, institutions, and scanner types. Evaluated on a single patch-level benchmark and four slide-level downstream tasks (two molecular and two morphological), Athena approaches the state-of-the-art and even surpasses several models trained on substantially larger datasets. This indicates that diversity across whole-slide images, rather than patch quantity alone, drives learning in histopathology foundation models.

Tissue segmentation is a routine preprocessing step to reduce the computational cost of whole slide image (WSI) analysis by excluding background regions. Traditional image processing techniques are commonly used for tissue segmentation, but often require manual adjustments to parameter values for atypical cases, fail to exclude all slide and scanning artifacts from the background, and are unable to segment adipose tissue. Pen marking artifacts in particular can be a potential source of bias for subsequent analyses if not removed. In addition, several applications require the separation of individual cross-sections, which can be challenging due to tissue fragmentation and adjacent positioning. To address these problems, we develop a convolutional neural network for tissue and pen marking segmentation using a dataset of 200 H&E stained WSIs. For separating tissue cross-sections, we propose a novel post-processing method based on clustering predicted centroid locations of the cross-sections in a 2D histogram. On an independent test set, the model achieved a mean Dice score of 0.981pm0.033 for tissue segmentation and a mean Dice score of 0.912pm0.090 for pen marking segmentation. The mean absolute difference between the number of annotated and separated cross-sections was 0.075pm0.350. Our results demonstrate that the proposed model can accurately segment H&E stained tissue cross-sections and pen markings in WSIs while being robust to many common slide and scanning artifacts. The model with trained model parameters and post-processing method are made publicly available as a Python package called SlideSegmenter.

Detecting and classifying cells in histopathology H\&E stained whole-slide images is a core task in computational pathology, as it provides valuable insight into the tumor microenvironment. In this work we investigate the impact of ground truth formats on the models performance. Additionally, cell-tissue interactions are considered by providing tissue segmentation predictions as input to the cell detection model. We find that a "soft", probability-map instance segmentation ground truth leads to best model performance. Combined with cell-tissue interaction and test-time augmentation our Soft Cell-Tissue-Model (SoftCTM) achieves 0.7172 mean F1-Score on the Overlapped Cell On Tissue (OCELOT) test set, achieving the third best overall score in the OCELOT 2023 Challenge. The source code for our approach is made publicly available at https://github.com/lely475/ocelot23algo.

Developing self-supervised learning (SSL) models that can learn universal and transferable representations of H&E gigapixel whole-slide images (WSIs) is becoming increasingly valuable in computational pathology. These models hold the potential to advance critical tasks such as few-shot classification, slide retrieval, and patient stratification. Existing approaches for slide representation learning extend the principles of SSL from small images (e.g., 224 x 224 patches) to entire slides, usually by aligning two different augmentations (or views) of the slide. Yet the resulting representation remains constrained by the limited clinical and biological diversity of the views. Instead, we postulate that slides stained with multiple markers, such as immunohistochemistry, can be used as different views to form a rich task-agnostic training signal. To this end, we introduce Madeleine, a multimodal pretraining strategy for slide representation learning. Madeleine is trained with a dual global-local cross-stain alignment objective on large cohorts of breast cancer samples (N=4,211 WSIs across five stains) and kidney transplant samples (N=12,070 WSIs across four stains). We demonstrate the quality of slide representations learned by Madeleine on various downstream evaluations, ranging from morphological and molecular classification to prognostic prediction, comprising 21 tasks using 7,299 WSIs from multiple medical centers. Code is available at https://github.com/mahmoodlab/MADELEINE.

Spatial transcriptomics (ST) enables interrogating the molecular composition of tissue with ever-increasing resolution, depth, and sensitivity. However, costs, rapidly evolving technology, and lack of standards have constrained computational methods in ST to narrow tasks and small cohorts. In addition, the underlying tissue morphology as reflected by H&E-stained whole slide images (WSIs) encodes rich information often overlooked in ST studies. Here, we introduce HEST-1k, a collection of 1,108 spatial transcriptomic profiles, each linked to a WSI and metadata. HEST-1k was assembled using HEST-Library from 131 public and internal cohorts encompassing 25 organs, two species (Homo Sapiens and Mus Musculus), and 320 cancer samples from 25 cancer types. HEST-1k processing enabled the identification of 1.5 million expression--morphology pairs and 60 million nuclei. HEST-1k is tested on three use cases: (1) benchmarking foundation models for histopathology (HEST-Benchmark), (2) biomarker identification, and (3) multimodal representation learning. HEST-1k, HEST-Library, and HEST-Benchmark can be freely accessed via https://github.com/mahmoodlab/hest.

Millions of melanocytic skin lesions are examined by pathologists each year, the majority of which concern common nevi (i.e., ordinary moles). While most of these lesions can be diagnosed in seconds, writing the corresponding pathology report is much more time-consuming. Automating part of the report writing could, therefore, alleviate the increasing workload of pathologists. In this work, we develop a vision-language model specifically for the pathology domain of cutaneous melanocytic lesions. The model follows the Contrastive Captioner framework and was trained and evaluated using a melanocytic lesion dataset of 42,512 H&E-stained whole slide images and 19,645 corresponding pathology reports. Our results show that the quality scores of model-generated reports were on par with pathologist-written reports for common nevi, assessed by an expert pathologist in a reader study. While report generation revealed to be more difficult for rare melanocytic lesion subtypes, the cross-modal retrieval performance for these cases was considerably better.

Vision-language models in pathology enable multimodal case retrieval and automated report generation. Many of the models developed so far, however, have been trained on pathology reports that include information which cannot be inferred from paired whole slide images (e.g., patient history), potentially leading to hallucinated sentences in generated reports. To this end, we investigate how the selection of information from pathology reports for vision-language modeling affects the quality of the multimodal representations and generated reports. More concretely, we compare a model trained on full reports against a model trained on preprocessed reports that only include sentences describing the cell and tissue appearances based on the H&E-stained slides. For the experiments, we built upon the BLIP-2 framework and used a cutaneous melanocytic lesion dataset of 42,433 H&E-stained whole slide images and 19,636 corresponding pathology reports. Model performance was assessed using image-to-text and text-to-image retrieval, as well as qualitative evaluation of the generated reports by an expert pathologist. Our results demonstrate that text preprocessing prevents hallucination in report generation. Despite the improvement in the quality of the generated reports, training the vision-language model on full reports showed better cross-modal retrieval performance.

Gastrointestinal (GI) diseases represent a clinically significant burden, necessitating precise diagnostic approaches to optimize patient outcomes. Conventional histopathological diagnosis suffers from limited reproducibility and diagnostic variability. To overcome these limitations, we develop Digepath, a specialized foundation model for GI pathology. Our framework introduces a dual-phase iterative optimization strategy combining pretraining with fine-screening, specifically designed to address the detection of sparsely distributed lesion areas in whole-slide images. Digepath is pretrained on over 353 million multi-scale images from 210,043 H&E-stained slides of GI diseases. It attains state-of-the-art performance on 33 out of 34 tasks related to GI pathology, including pathological diagnosis, protein expression status prediction, gene mutation prediction, and prognosis evaluation. We further translate the intelligent screening module for early GI cancer and achieve near-perfect 99.70% sensitivity across nine independent medical institutions. This work not only advances AI-driven precision pathology for GI diseases but also bridge critical gaps in histopathological practice.

Foundation models pretrained on large-scale datasets are revolutionizing the field of computational pathology (CPath). The generalization ability of foundation models is crucial for the success in various downstream clinical tasks. However, current foundation models have only been evaluated on a limited type and number of tasks, leaving their generalization ability and overall performance unclear. To address this gap, we established a most comprehensive benchmark to evaluate the performance of off-the-shelf foundation models across six distinct clinical task types, encompassing a total of 39 specific tasks. Our findings reveal that existing foundation models excel at certain task types but struggle to effectively handle the full breadth of clinical tasks. To improve the generalization of pathology foundation models, we propose a unified knowledge distillation framework consisting of both expert and self knowledge distillation, where the former allows the model to learn from the knowledge of multiple expert models, while the latter leverages self-distillation to enable image representation learning via local-global alignment. Based on this framework, a Generalizable Pathology Foundation Model (GPFM) is pretrained on a large-scale dataset consisting of 190 million images from around 86,000 public H&E whole slides across 34 major tissue types. Evaluated on the established benchmark, GPFM achieves an impressive average rank of 1.36, with 29 tasks ranked 1st, while the the second-best model, UNI, attains an average rank of 2.96, with only 4 tasks ranked 1st. The superior generalization of GPFM demonstrates its exceptional modeling capabilities across a wide range of clinical tasks, positioning it as a new cornerstone for feature representation in CPath.

We present WeakSTIL, an interpretable two-stage weak label deep learning pipeline for scoring the percentage of stromal tumor infiltrating lymphocytes (sTIL%) in H&E-stained whole-slide images (WSIs) of breast cancer tissue. The sTIL% score is a prognostic and predictive biomarker for many solid tumor types. However, due to the high labeling efforts and high intra- and interobserver variability within and between expert annotators, this biomarker is currently not used in routine clinical decision making. WeakSTIL compresses tiles of a WSI using a feature extractor pre-trained with self-supervised learning on unlabeled histopathology data and learns to predict precise sTIL% scores for each tile in the tumor bed by using a multiple instance learning regressor that only requires a weak WSI-level label. By requiring only a weak label, we overcome the large annotation efforts required to train currently existing TIL detection methods. We show that WeakSTIL is at least as good as other TIL detection methods when predicting the WSI-level sTIL% score, reaching a coefficient of determination of 0.45pm0.15 when compared to scores generated by an expert pathologist, and an AUC of 0.89pm0.05 when treating it as the clinically interesting sTIL-high vs sTIL-low classification task. Additionally, we show that the intermediate tile-level predictions of WeakSTIL are highly interpretable, which suggests that WeakSTIL pays attention to latent features related to the number of TILs and the tissue type. In the future, WeakSTIL may be used to provide consistent and interpretable sTIL% predictions to stratify breast cancer patients into targeted therapy arms.

The widespread and rapid adoption of AI-generated content, created by models such as Generative Adversarial Networks (GANs) and Diffusion Models, has revolutionized the digital media landscape by allowing efficient and creative content generation. However, these models also blur the difference between real images and AI-generated synthetic images, raising concerns regarding content authenticity and integrity. While many existing solutions to detect fake images focus solely on classification and higher-resolution images, they often lack transparency in their decision-making, making it difficult for users to understand why an image is classified as fake. In this paper, we present VERITAS, a comprehensive framework that not only accurately detects whether a small (32x32) image is AI-generated but also explains why it was classified that way through artifact localization and semantic reasoning. VERITAS produces human-readable explanations that describe key artifacts in synthetic images. We show that this architecture offers clear explanations of the basis of zero-shot synthetic image detection tasks. Code and relevant prompts can be found at https://github.com/V-i-g-n-e-s-h-N/VERITAS .

The Euclid satellite is an ESA mission that was launched in July 2023. \Euclid is working in its regular observing mode with the target of observing an area of 14,000~deg^2 with two instruments, the Visible Camera (VIS) and the Near IR Spectrometer and Photometer (NISP) down to I_{rm E} = 24.5~mag (10, sigma) in the Euclid Wide Survey. Ground-based imaging data in the ugriz bands complement the \Euclid data to enable photo-z determination and VIS PSF modeling for week lensing analysis. Euclid investigates the distance-redshift relation and the evolution of cosmic structures by measuring shapes and redshifts of galaxies and clusters of galaxies out to zsim 2. Generating the multi-wavelength catalogues from \Euclid and ground-based data is an essential part of the \Euclid data processing system. In the framework of the \Euclid Science Ground Segment (SGS), the aim of the MER Processing Function (PF) pipeline is to detect objects in the \Euclid imaging data, measure their properties, and MERge them into a single multi-wavelength catalogue. The MER PF pipeline performs source detection on both visible (VIS) and near-infrared (NIR) images and offers four different photometric measurements: Kron total flux, aperture photometry on PSF-matched images, template fitting photometry, and S\'ersic fitting photometry. Furthermore, the MER PF pipeline measures a set of ancillary quantities, spanning from morphology to quality flags, to better characterise all detected sources. In this paper, we show how the MER PF pipeline is designed, detailing its main steps, and we show that the pipeline products meet the tight requirements that Euclid aims to achieve on photometric accuracy. We also present the other measurements (e.g. morphology) that are included in the OU-MER output catalogues and we list all output products coming out of the MER PF pipeline.

In this work, we present DreamDance, a novel method for animating human images using only skeleton pose sequences as conditional inputs. Existing approaches struggle with generating coherent, high-quality content in an efficient and user-friendly manner. Concretely, baseline methods relying on only 2D pose guidance lack the cues of 3D information, leading to suboptimal results, while methods using 3D representation as guidance achieve higher quality but involve a cumbersome and time-intensive process. To address these limitations, DreamDance enriches 3D geometry cues from 2D poses by introducing an efficient diffusion model, enabling high-quality human image animation with various guidance. Our key insight is that human images naturally exhibit multiple levels of correlation, progressing from coarse skeleton poses to fine-grained geometry cues, and further from these geometry cues to explicit appearance details. Capturing such correlations could enrich the guidance signals, facilitating intra-frame coherency and inter-frame consistency. Specifically, we construct the TikTok-Dance5K dataset, comprising 5K high-quality dance videos with detailed frame annotations, including human pose, depth, and normal maps. Next, we introduce a Mutually Aligned Geometry Diffusion Model to generate fine-grained depth and normal maps for enriched guidance. Finally, a Cross-domain Controller incorporates multi-level guidance to animate human images effectively with a video diffusion model. Extensive experiments demonstrate that our method achieves state-of-the-art performance in animating human images.

Vertebral labelling and segmentation are two fundamental tasks in an automated spine processing pipeline. Reliable and accurate processing of spine images is expected to benefit clinical decision-support systems for diagnosis, surgery planning, and population-based analysis on spine and bone health. However, designing automated algorithms for spine processing is challenging predominantly due to considerable variations in anatomy and acquisition protocols and due to a severe shortage of publicly available data. Addressing these limitations, the Large Scale Vertebrae Segmentation Challenge (VerSe) was organised in conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) in 2019 and 2020, with a call for algorithms towards labelling and segmentation of vertebrae. Two datasets containing a total of 374 multi-detector CT scans from 355 patients were prepared and 4505 vertebrae have individually been annotated at voxel-level by a human-machine hybrid algorithm (https://osf.io/nqjyw/, https://osf.io/t98fz/). A total of 25 algorithms were benchmarked on these datasets. In this work, we present the the results of this evaluation and further investigate the performance-variation at vertebra-level, scan-level, and at different fields-of-view. We also evaluate the generalisability of the approaches to an implicit domain shift in data by evaluating the top performing algorithms of one challenge iteration on data from the other iteration. The principal takeaway from VerSe: the performance of an algorithm in labelling and segmenting a spine scan hinges on its ability to correctly identify vertebrae in cases of rare anatomical variations. The content and code concerning VerSe can be accessed at: https://github.com/anjany/verse.

Coronavirus disease 2019 (COVID-19) has been diagnosed automatically using Machine Learning algorithms over chest X-ray (CXR) images. However, most of the earlier studies used Deep Learning models over scarce datasets bearing the risk of overfitting. Additionally, previous studies have revealed the fact that deep networks are not reliable for classification since their decisions may originate from irrelevant areas on the CXRs. Therefore, in this study, we propose Operational Segmentation Network (OSegNet) that performs detection by segmenting COVID-19 pneumonia for a reliable diagnosis. To address the data scarcity encountered in training and especially in evaluation, this study extends the largest COVID-19 CXR dataset: QaTa-COV19 with 121,378 CXRs including 9258 COVID-19 samples with their corresponding ground-truth segmentation masks that are publicly shared with the research community. Consequently, OSegNet has achieved a detection performance with the highest accuracy of 99.65% among the state-of-the-art deep models with 98.09% precision.

Light emission from galaxies exhibit diverse brightness profiles, influenced by factors such as galaxy type, structural features and interactions with other galaxies. Elliptical galaxies feature more uniform light distributions, while spiral and irregular galaxies have complex, varied light profiles due to their structural heterogeneity and star-forming activity. In addition, galaxies with an active galactic nucleus (AGN) feature intense, concentrated emission from gas accretion around supermassive black holes, superimposed on regular galactic light, while quasi-stellar objects (QSO) are the extreme case of the AGN emission dominating the galaxy. The challenge of identifying AGN and QSO has been discussed many times in the literature, often requiring multi-wavelength observations. This paper introduces a novel approach to identify AGN and QSO from a single image. Diffusion models have been recently developed in the machine-learning literature to generate realistic-looking images of everyday objects. Utilising the spatial resolving power of the Euclid VIS images, we created a diffusion model trained on one million sources, without using any source pre-selection or labels. The model learns to reconstruct light distributions of normal galaxies, since the population is dominated by them. We condition the prediction of the central light distribution by masking the central few pixels of each source and reconstruct the light according to the diffusion model. We further use this prediction to identify sources that deviate from this profile by examining the reconstruction error of the few central pixels regenerated in each source's core. Our approach, solely using VIS imaging, features high completeness compared to traditional methods of AGN and QSO selection, including optical, near-infrared, mid-infrared, and X-rays.

Coronavirus disease (COVID-19) is a pandemic disease, which has already caused thousands of causalities and infected several millions of people worldwide. Any technological tool enabling rapid screening of the COVID-19 infection with high accuracy can be crucially helpful to healthcare professionals. The main clinical tool currently in use for the diagnosis of COVID-19 is the Reverse transcription polymerase chain reaction (RT-PCR), which is expensive, less-sensitive and requires specialized medical personnel. X-ray imaging is an easily accessible tool that can be an excellent alternative in the COVID-19 diagnosis. This research was taken to investigate the utility of artificial intelligence (AI) in the rapid and accurate detection of COVID-19 from chest X-ray images. The aim of this paper is to propose a robust technique for automatic detection of COVID-19 pneumonia from digital chest X-ray images applying pre-trained deep-learning algorithms while maximizing the detection accuracy. A public database was created by the authors combining several public databases and also by collecting images from recently published articles. The database contains a mixture of 423 COVID-19, 1485 viral pneumonia, and 1579 normal chest X-ray images. Transfer learning technique was used with the help of image augmentation to train and validate several pre-trained deep Convolutional Neural Networks (CNNs). The networks were trained to classify two different schemes: i) normal and COVID-19 pneumonia; ii) normal, viral and COVID-19 pneumonia with and without image augmentation. The classification accuracy, precision, sensitivity, and specificity for both the schemes were 99.7%, 99.7%, 99.7% and 99.55% and 97.9%, 97.95%, 97.9%, and 98.8%, respectively.

Bird's-eye-view (BEV) is a powerful and widely adopted representation for road scenes that captures surrounding objects and their spatial locations, along with overall context in the scene. In this work, we focus on bird's eye semantic segmentation, a task that predicts pixel-wise semantic segmentation in BEV from side RGB images. This task is made possible by simulators such as Carla, which allow for cheap data collection, arbitrary camera placements, and supervision in ways otherwise not possible in the real world. There are two main challenges to this task: the view transformation from side view to bird's eye view, as well as transfer learning to unseen domains. Existing work transforms between views through fully connected layers and transfer learns via GANs. This suffers from a lack of depth reasoning and performance degradation across domains. Our novel 2-staged perception pipeline explicitly predicts pixel depths and combines them with pixel semantics in an efficient manner, allowing the model to leverage depth information to infer objects' spatial locations in the BEV. In addition, we transfer learning by abstracting high-level geometric features and predicting an intermediate representation that is common across different domains. We publish a new dataset called BEVSEG-Carla and show that our approach improves state-of-the-art by 24% mIoU and performs well when transferred to a new domain.

The use of convolutional neural networks (CNNs) has accelerated the progress of handwritten character classification/recognition. Handwritten character recognition (HCR) has found applications in various domains, such as traffic signal detection, language translation, and document information extraction. However, the widespread use of existing HCR technology is yet to be seen as it does not provide reliable character recognition with outstanding accuracy. One of the reasons for unreliable HCR is that existing HCR methods do not take the handwriting styles of non-native writers into account. Hence, further improvement is needed to ensure the reliability and extensive deployment of character recognition technologies for critical tasks. In this work, the classification of English characters written by non-native users is performed by proposing a custom-tailored CNN model. We train this CNN with a new dataset called the handwritten isolated English character (HIEC) dataset. This dataset consists of 16,496 images collected from 260 persons. This paper also includes an ablation study of our CNN by adjusting hyperparameters to identify the best model for the HIEC dataset. The proposed model with five convolutional layers and one hidden layer outperforms state-of-the-art models in terms of character recognition accuracy and achieves an accuracy of 97.04%. Compared with the second-best model, the relative improvement of our model in terms of classification accuracy is 4.38%.

We present Envision3D, a novel method for efficiently generating high-quality 3D content from a single image. Recent methods that extract 3D content from multi-view images generated by diffusion models show great potential. However, it is still challenging for diffusion models to generate dense multi-view consistent images, which is crucial for the quality of 3D content extraction. To address this issue, we propose a novel cascade diffusion framework, which decomposes the challenging dense views generation task into two tractable stages, namely anchor views generation and anchor views interpolation. In the first stage, we train the image diffusion model to generate global consistent anchor views conditioning on image-normal pairs. Subsequently, leveraging our video diffusion model fine-tuned on consecutive multi-view images, we conduct interpolation on the previous anchor views to generate extra dense views. This framework yields dense, multi-view consistent images, providing comprehensive 3D information. To further enhance the overall generation quality, we introduce a coarse-to-fine sampling strategy for the reconstruction algorithm to robustly extract textured meshes from the generated dense images. Extensive experiments demonstrate that our method is capable of generating high-quality 3D content in terms of texture and geometry, surpassing previous image-to-3D baseline methods.

Machine Learning methods can learn how to reconstruct Magnetic Resonance Images and thereby accelerate acquisition, which is of paramount importance to the clinical workflow. Physics-informed networks incorporate the forward model of accelerated MRI reconstruction in the learning process. With increasing network complexity, robustness is not ensured when reconstructing data unseen during training. We aim to embed data consistency (DC) in deep networks while balancing the degree of network complexity. While doing so, we will assess whether either explicit or implicit enforcement of DC in varying network architectures is preferred to optimize performance. We propose a scheme called Cascades of Independently Recurrent Inference Machines (CIRIM) to assess DC through unrolled optimization. Herein we assess DC both implicitly by gradient descent and explicitly by a designed term. Extensive comparison of the CIRIM to CS as well as to other methods is performed: the E2EVN, CascadeNet, KIKINet, LPDNet, RIM, IRIM, and UNet. Models were trained and evaluated on T1-weighted and FLAIR contrast brain data, and T2-weighted knee data. Both 1D and 2D undersampling patterns were evaluated. Robustness was tested by reconstructing 7.5x prospectively undersampled 3D FLAIR MRI data of Multiple Sclerosis (MS) patients with white matter lesions. The CIRIM performed best when implicitly enforcing DC, while the E2EVN required an explicit DC formulation. In reconstructing MS patient data, prospectively acquired with a sampling pattern unseen during model training, the CIRIM maintained lesion contrast while efficiently denoising the images. The CIRIM showed highly promising generalization capabilities maintaining a very fair trade-off between reconstructed image quality and fast reconstruction times, which is crucial in the clinical workflow.

This study developed a novel method for detecting hypernuclear events recorded in nuclear emulsion sheets using machine learning techniques. The artificial neural network-based object detection model was trained on surrogate images created through Monte Carlo simulations and image-style transformations using generative adversarial networks. The performance of the proposed model was evaluated using alpha-decay events obtained from the J-PARC E07 emulsion data. The model achieved approximately twice the detection efficiency of conventional image processing and reduced the time spent on manual visual inspection by approximately 1/17. The established method was successfully applied to the detection of hypernuclear events. This approach is a state-of-the-art tool for discovering rare events recorded in nuclear emulsion sheets without any real data for training.

As a promising scheme of self-supervised learning, masked autoencoding has significantly advanced natural language processing and computer vision. Inspired by this, we propose a neat scheme of masked autoencoders for point cloud self-supervised learning, addressing the challenges posed by point cloud's properties, including leakage of location information and uneven information density. Concretely, we divide the input point cloud into irregular point patches and randomly mask them at a high ratio. Then, a standard Transformer based autoencoder, with an asymmetric design and a shifting mask tokens operation, learns high-level latent features from unmasked point patches, aiming to reconstruct the masked point patches. Extensive experiments show that our approach is efficient during pre-training and generalizes well on various downstream tasks. Specifically, our pre-trained models achieve 85.18% accuracy on ScanObjectNN and 94.04% accuracy on ModelNet40, outperforming all the other self-supervised learning methods. We show with our scheme, a simple architecture entirely based on standard Transformers can surpass dedicated Transformer models from supervised learning. Our approach also advances state-of-the-art accuracies by 1.5%-2.3% in the few-shot object classification. Furthermore, our work inspires the feasibility of applying unified architectures from languages and images to the point cloud.

Tuberculosis (TB) is a chronic lung disease that occurs due to bacterial infection and is one of the top 10 leading causes of death. Accurate and early detection of TB is very important, otherwise, it could be life-threatening. In this work, we have detected TB reliably from the chest X-ray images using image pre-processing, data augmentation, image segmentation, and deep-learning classification techniques. Several public databases were used to create a database of 700 TB infected and 3500 normal chest X-ray images for this study. Nine different deep CNNs (ResNet18, ResNet50, ResNet101, ChexNet, InceptionV3, Vgg19, DenseNet201, SqueezeNet, and MobileNet), which were used for transfer learning from their pre-trained initial weights and trained, validated and tested for classifying TB and non-TB normal cases. Three different experiments were carried out in this work: segmentation of X-ray images using two different U-net models, classification using X-ray images, and segmented lung images. The accuracy, precision, sensitivity, F1-score, specificity in the detection of tuberculosis using X-ray images were 97.07 %, 97.34 %, 97.07 %, 97.14 % and 97.36 % respectively. However, segmented lungs for the classification outperformed than whole X-ray image-based classification and accuracy, precision, sensitivity, F1-score, specificity were 99.9 %, 99.91 %, 99.9 %, 99.9 %, and 99.52 % respectively. The paper also used a visualization technique to confirm that CNN learns dominantly from the segmented lung regions results in higher detection accuracy. The proposed method with state-of-the-art performance can be useful in the computer-aided faster diagnosis of tuberculosis.

We present griz light curves of 251 Type Ia Supernovae (SNe Ia) from the first 3 years of the Dark Energy Survey Supernova Program's (DES-SN) spectroscopically classified sample. The photometric pipeline described in this paper produces the calibrated fluxes and associated uncertainties used in the cosmological parameter analysis (Brout et al. 2018-SYS, DES Collaboration et al. 2018) by employing a scene modeling approach that simultaneously forward models a variable transient flux and temporally constant host galaxy. We inject artificial point sources onto DECam images to test the accuracy of our photometric method. Upon comparison of input and measured artificial supernova fluxes, we find flux biases peak at 3 mmag. We require corrections to our photometric uncertainties as a function of host galaxy surface brightness at the transient location, similar to that seen by the DES Difference Imaging Pipeline used to discover transients. The public release of the light curves can be found at https://des.ncsa.illinois.edu/releases/sn.

This paper presents the specification, design, and development of the Visible Camera (VIS) on the ESA Euclid mission. VIS is a large optical-band imager with a field of view of 0.54 deg^2 sampled at 0.1" with an array of 609 Megapixels and spatial resolution of 0.18". It will be used to survey approximately 14,000 deg^2 of extragalactic sky to measure the distortion of galaxies in the redshift range z=0.1-1.5 resulting from weak gravitational lensing, one of the two principal cosmology probes of Euclid. With photometric redshifts, the distribution of dark matter can be mapped in three dimensions, and, from how this has changed with look-back time, the nature of dark energy and theories of gravity can be constrained. The entire VIS focal plane will be transmitted to provide the largest images of the Universe from space to date, reaching m_AB>24.5 with S/N >10 in a single broad I_E~(r+i+z) band over a six year survey. The particularly challenging aspects of the instrument are the control and calibration of observational biases, which lead to stringent performance requirements and calibration regimes. With its combination of spatial resolution, calibration knowledge, depth, and area covering most of the extra-Galactic sky, VIS will also provide a legacy data set for many other fields. This paper discusses the rationale behind the VIS concept and describes the instrument design and development before reporting the pre-launch performance derived from ground calibrations and brief results from the in-orbit commissioning. VIS should reach fainter than m_AB=25 with S/N>10 for galaxies of full-width half-maximum of 0.3" in a 1.3" diameter aperture over the Wide Survey, and m_AB>26.4 for a Deep Survey that will cover more than 50 deg^2. The paper also describes how VIS works with the other Euclid components of survey, telescope, and science data processing to extract the cosmological information.

The DESI Legacy Imaging Surveys are a combination of three public projects (the Dark Energy Camera Legacy Survey, the Beijing-Arizona Sky Survey, and the Mayall z-band Legacy Survey) that will jointly image approximately 14,000 deg^2 of the extragalactic sky visible from the northern hemisphere in three optical bands (g, r, and z) using telescopes at the Kitt Peak National Observatory and the Cerro Tololo Inter-American Observatory. The combined survey footprint is split into two contiguous areas by the Galactic plane. The optical imaging is conducted using a unique strategy of dynamically adjusting the exposure times and pointing selection during observing that results in a survey of nearly uniform depth. In addition to calibrated images, the project is delivering a catalog, constructed by using a probabilistic inference-based approach to estimate source shapes and brightnesses. The catalog includes photometry from the grz optical bands and from four mid-infrared bands (at 3.4, 4.6, 12 and 22 micorons) observed by the Wide-field Infrared Survey Explorer (WISE) satellite during its full operational lifetime. The project plans two public data releases each year. All the software used to generate the catalogs is also released with the data. This paper provides an overview of the Legacy Surveys project.

We present the MULTIMODAL UNIVERSE, a large-scale multimodal dataset of scientific astronomical data, compiled specifically to facilitate machine learning research. Overall, the MULTIMODAL UNIVERSE contains hundreds of millions of astronomical observations, constituting 100\,TB of multi-channel and hyper-spectral images, spectra, multivariate time series, as well as a wide variety of associated scientific measurements and "metadata". In addition, we include a range of benchmark tasks representative of standard practices for machine learning methods in astrophysics. This massive dataset will enable the development of large multi-modal models specifically targeted towards scientific applications. All codes used to compile the MULTIMODAL UNIVERSE and a description of how to access the data is available at https://github.com/MultimodalUniverse/MultimodalUniverse

Vision foundation models (FMs) are accelerating the development of digital pathology algorithms and transforming biomedical research. These models learn, in a self-supervised manner, to represent histological features in highly heterogeneous tiles extracted from whole-slide images (WSIs) of real-world patient samples. The performance of these FMs is significantly influenced by the size, diversity, and balance of the pre-training data. However, data selection has been primarily guided by expert knowledge at the WSI level, focusing on factors such as disease classification and tissue types, while largely overlooking the granular details available at the tile level. In this paper, we investigate the potential of unsupervised automatic data curation at the tile-level, taking into account 350 million tiles. Specifically, we apply hierarchical clustering trees to pre-extracted tile embeddings, allowing us to sample balanced datasets uniformly across the embedding space of the pretrained FM. We further identify these datasets are subject to a trade-off between size and balance, potentially compromising the quality of representations learned by FMs, and propose tailored batch sampling strategies to mitigate this effect. We demonstrate the effectiveness of our method through improved performance on a diverse range of clinically relevant downstream tasks.

Modern astronomical surveys, such as the Euclid mission, produce high-dimensional, multi-modal data sets that include imaging and spectroscopic information for millions of galaxies. These data serve as an ideal benchmark for large, pre-trained multi-modal models, which can leverage vast amounts of unlabelled data. In this work, we present the first exploration of Euclid data with AstroPT, an autoregressive multi-modal foundation model trained on approximately 300 000 optical and infrared Euclid images and spectral energy distributions (SEDs) from the first Euclid Quick Data Release. We compare self-supervised pre-training with baseline fully supervised training across several tasks: galaxy morphology classification; redshift estimation; similarity searches; and outlier detection. Our results show that: (a) AstroPT embeddings are highly informative, correlating with morphology and effectively isolating outliers; (b) including infrared data helps to isolate stars, but degrades the identification of edge-on galaxies, which are better captured by optical images; (c) simple fine-tuning of these embeddings for photometric redshift and stellar mass estimation outperforms a fully supervised approach, even when using only 1% of the training labels; and (d) incorporating SED data into AstroPT via a straightforward multi-modal token-chaining method improves photo-z predictions, and allow us to identify potentially more interesting anomalies (such as ringed or interacting galaxies) compared to a model pre-trained solely on imaging data.

We present a re-discovery of G278.94+1.35 as possibly one of the largest known Galactic supernova remnants (SNR) - that we name Diprotodon. While previously established as a Galactic SNR, Diprotodon is visible in our new EMU and GLEAM radio continuum images at an angular size of 3.33x3.23 deg, much larger than previously measured. At the previously suggested distance of 2.7 kpc, this implies a diameter of 157x152 pc. This size would qualify Diprotodon as the largest known SNR and pushes our estimates of SNR sizes to the upper limits. We investigate the environment in which the SNR is located and examine various scenarios that might explain such a large and relatively bright SNR appearance. We find that Diprotodon is most likely at a much closer distance of sim1 kpc, implying its diameter is 58x56 pc and it is in the radiative evolutionary phase. We also present a new Fermi-LAT data analysis that confirms the angular extent of the SNR in gamma-rays. The origin of the high-energy emission remains somewhat puzzling, and the scenarios we explore reveal new puzzles, given this unexpected and unique observation of a seemingly evolved SNR having a hard GeV spectrum with no breaks. We explore both leptonic and hadronic scenarios, as well as the possibility that the high-energy emission arises from the leftover particle population of a historic pulsar wind nebula.

African agriculture is undergoing rapid transformation. Annual maps of crop fields are key to understanding the nature of this transformation, but such maps are currently lacking and must be developed using advanced machine learning models trained on high resolution remote sensing imagery. To enable the development of such models, we delineated field boundaries in 33,746 Planet images captured between 2017 and 2023 across the continent using a custom labeling platform with built-in procedures for assessing and mitigating label error. We collected 42,403 labels, including 7,204 labels arising from tasks dedicated to assessing label quality (Class 1 labels), 32,167 from sites mapped once by a single labeller (Class 2) and 3,032 labels from sites where 3 or more labellers were tasked to map the same location (Class 4). Class 1 labels were used to calculate labeller-specific quality scores, while Class 1 and 4 sites mapped by at least 3 labellers were used to further evaluate label uncertainty using a Bayesian risk metric. Quality metrics showed that label quality was moderately high (0.75) for measures of total field extent, but low regarding the number of individual fields delineated (0.33), and the position of field edges (0.05). These values are expected when delineating small-scale fields in 3-5 m resolution imagery, which can be too coarse to reliably distinguish smaller fields, particularly in dense croplands, and therefore requires substantial labeller judgement. Nevertheless, previous work shows that such labels can train effective field mapping models. Furthermore, this large, probabilistic sample on its own provides valuable insight into regional agricultural characteristics, highlighting variations in the median field size and density. The imagery and vectorized labels along with quality information is available for download from two public repositories.

Lack of rigorous reproducibility and validation are major hurdles for scientific development across many fields. Materials science in particular encompasses a variety of experimental and theoretical approaches that require careful benchmarking. Leaderboard efforts have been developed previously to mitigate these issues. However, a comprehensive comparison and benchmarking on an integrated platform with multiple data modalities with both perfect and defect materials data is still lacking. This work introduces JARVIS-Leaderboard, an open-source and community-driven platform that facilitates benchmarking and enhances reproducibility. The platform allows users to set up benchmarks with custom tasks and enables contributions in the form of dataset, code, and meta-data submissions. We cover the following materials design categories: Artificial Intelligence (AI), Electronic Structure (ES), Force-fields (FF), Quantum Computation (QC) and Experiments (EXP). For AI, we cover several types of input data, including atomic structures, atomistic images, spectra, and text. For ES, we consider multiple ES approaches, software packages, pseudopotentials, materials, and properties, comparing results to experiment. For FF, we compare multiple approaches for material property predictions. For QC, we benchmark Hamiltonian simulations using various quantum algorithms and circuits. Finally, for experiments, we use the inter-laboratory approach to establish benchmarks. There are 1281 contributions to 274 benchmarks using 152 methods with more than 8 million data-points, and the leaderboard is continuously expanding. The JARVIS-Leaderboard is available at the website: https://pages.nist.gov/jarvis_leaderboard

The Ultraviolet Near-Infrared Optical Northern Survey (UNIONS) is a "collaboration of collaborations" that is using the Canada-France-Hawai'i Telescope, the Pan-STARRS telescopes, and the Subaru Observatory to obtain ugriz images of a core survey region of 6250 deg^2 of the northern sky. The 10sigma point source depth of the data, as measured within a 2-arcsecond diameter aperture, are [u,g,r,i,z] = [23.7, 24.5, 24.2, 23.8, 23.3]\ in AB magnitudes. UNIONS is addressing some of the most fundamental questions in astronomy, including the properties of dark matter, the growth of structure in the Universe from the very smallest galaxies to large-scale structure, and the assembly of the Milky Way. It is set to become the major ground-based legacy survey for the northern hemisphere for the next decade and provides an essential northern complement to the static-sky science of the Vera C. Rubin Observatory's Legacy Survey of Space and Time. UNIONS supports the core science mission of the {\it Euclid} space mission by providing the data necessary in the northern hemisphere for the calibration of the wavelength dependence of the {\it Euclid} point-spread function and derivation of photometric redshifts in the North Galactic Cap. This region contains the highest quality sky for {\it Euclid}, with low backgrounds from the zodiacal light, stellar density, extinction, and emission from Galactic cirrus. Here, we describe the UNIONS survey components, science goals, data products, and the current status of the overall program.

Hand shadow puppetry, also known as shadowgraphy or ombromanie, is a form of theatrical art and storytelling where hand shadows are projected onto flat surfaces to create illusions of living creatures. The skilled performers create these silhouettes by hand positioning, finger movements, and dexterous gestures to resemble shadows of animals and objects. Due to the lack of practitioners and a seismic shift in people's entertainment standards, this art form is on the verge of extinction. To facilitate its preservation and proliferate it to a wider audience, we introduce {rm H{small A}SP{small E}R}, a novel dataset consisting of 15,000 images of hand shadow puppets across 15 classes extracted from both professional and amateur hand shadow puppeteer clips. We provide a detailed statistical analysis of the dataset and employ a range of pretrained image classification models to establish baselines. Our findings show a substantial performance superiority of skip-connected convolutional models over attention-based transformer architectures. We also find that lightweight models, such as MobileNetV2, suited for mobile applications and embedded devices, perform comparatively well. We surmise that such low-latency architectures can be useful in developing ombromanie teaching tools, and we create a prototype application to explore this surmission. Keeping the best-performing model ResNet34 under the limelight, we conduct comprehensive feature-spatial, explainability, and error analyses to gain insights into its decision-making process. To the best of our knowledge, this is the first documented dataset and research endeavor to preserve this dying art for future generations, with computer vision approaches. Our code and data will be publicly available.

Immunohistochemical (IHC) staining highlights the molecular information critical to diagnostics in tissue samples. However, compared to H&E staining, IHC staining can be much more expensive in terms of both labor and the laboratory equipment required. This motivates recent research that demonstrates that the correlations between the morphological information present in the H&E-stained slides and the molecular information in the IHC-stained slides can be used for H&E-to-IHC stain translation. However, due to a lack of pixel-perfect H&E-IHC groundtruth pairs, most existing methods have resorted to relying on expert annotations. To remedy this situation, we present a new loss function, Adaptive Supervised PatchNCE (ASP), to directly deal with the input to target inconsistencies in a proposed H&E-to-IHC image-to-image translation framework. The ASP loss is built upon a patch-based contrastive learning criterion, named Supervised PatchNCE (SP), and augments it further with weight scheduling to mitigate the negative impact of noisy supervision. Lastly, we introduce the Multi-IHC Stain Translation (MIST) dataset, which contains aligned H&E-IHC patches for 4 different IHC stains critical to breast cancer diagnosis. In our experiment, we demonstrate that our proposed method outperforms existing image-to-image translation methods for stain translation to multiple IHC stains. All of our code and datasets are available at https://github.com/lifangda01/AdaptiveSupervisedPatchNCE.

In this paper, a multi-scale visual transformer model, referred as GasHis-Transformer, is proposed for Gastric Histopathological Image Detection (GHID), which enables the automatic global detection of gastric cancer images. GasHis-Transformer model consists of two key modules designed to extract global and local information using a position-encoded transformer model and a convolutional neural network with local convolution, respectively. A publicly available hematoxylin and eosin (H&E) stained gastric histopathological image dataset is used in the experiment. Furthermore, a Dropconnect based lightweight network is proposed to reduce the model size and training time of GasHis-Transformer for clinical applications with improved confidence. Moreover, a series of contrast and extended experiments verify the robustness, extensibility and stability of GasHis-Transformer. In conclusion, GasHis-Transformer demonstrates high global detection performance and shows its significant potential in GHID task.

Image-to-image translation (I2I) methods allow the generation of artificial images that share the content of the original image but have a different style. With the advances in Generative Adversarial Networks (GANs)-based methods, I2I methods enabled the generation of artificial images that are indistinguishable from natural images. Recently, I2I methods were also employed in histopathology for generating artificial images of in silico stained tissues from a different type of staining. We refer to this process as stain transfer. The number of I2I variants is constantly increasing, which makes a well justified choice of the most suitable I2I methods for stain transfer challenging. In our work, we compare twelve stain transfer approaches, three of which are based on traditional and nine on GAN-based image processing methods. The analysis relies on complementary quantitative measures for the quality of image translation, the assessment of the suitability for deep learning-based tissue grading, and the visual evaluation by pathologists. Our study highlights the strengths and weaknesses of the stain transfer approaches, thereby allowing a rational choice of the underlying I2I algorithms. Code, data, and trained models for stain transfer between H&E and Masson's Trichrome staining will be made available online.

Assessing resection margins is central to pathological specimen evaluation and has profound implications for patient outcomes. Current practice employs physical inking, which is applied variably, and cautery artifacts can obscure the true margin on histological sections. We present a virtual inking network (VIN) that autonomously localizes the surgical cut surface on whole-slide images, reducing reliance on inks and standardizing margin-focused review. VIN uses a frozen foundation model as the feature extractor and a compact two-layer multilayer perceptron trained for patch-level classification of cautery-consistent features. The dataset comprised 120 hematoxylin and eosin (H&E) stained slides from 12 human tonsil tissue blocks, resulting in ~2 TB of uncompressed raw image data, where a board-certified pathologist provided boundary annotations. In blind testing with 20 slides from previously unseen blocks, VIN produced coherent margin overlays that qualitatively aligned with expert annotations across serial sections. Quantitatively, region-level accuracy was ~73.3% across the test set, with errors largely confined to limited areas that did not disrupt continuity of the whole-slide margin map. These results indicate that VIN captures cautery-related histomorphology and can provide a reproducible, ink-free margin delineation suitable for integration into routine digital pathology workflows and for downstream measurement of margin distances.

Autoregressive models, built based on the Next Token Prediction (NTP) paradigm, show great potential in developing a unified framework that integrates both language and vision tasks. In this work, we rethink the NTP for autoregressive image generation and propose a novel Next Patch Prediction (NPP) paradigm. Our key idea is to group and aggregate image tokens into patch tokens containing high information density. With patch tokens as a shorter input sequence, the autoregressive model is trained to predict the next patch, thereby significantly reducing the computational cost. We further propose a multi-scale coarse-to-fine patch grouping strategy that exploits the natural hierarchical property of image data. Experiments on a diverse range of models (100M-1.4B parameters) demonstrate that the next patch prediction paradigm could reduce the training cost to around 0.6 times while improving image generation quality by up to 1.0 FID score on the ImageNet benchmark. We highlight that our method retains the original autoregressive model architecture without introducing additional trainable parameters or specifically designing a custom image tokenizer, thus ensuring flexibility and seamless adaptation to various autoregressive models for visual generation.

The Euclid mission seeks to understand the Universe expansion history and the nature of dark energy, which requires a very accurate estimate of redshift distribution. Achieving this accuracy relies on reference samples with spectroscopic redshifts, together with a procedure to match them to survey sources for which only photometric redshifts are available. One important source of systematic uncertainty is the mismatch in photometric properties between galaxies in the Euclid survey and the reference objects. We develop a method to degrade the photometry of objects with deep photometry to match the properties of any shallower survey in the multi-band photometric space, preserving all the correlations between the fluxes and their uncertainties. We compare our transfer method with more demanding image-based methods, such as Balrog from the Dark Energy Survey Collaboration. According to metrics, our method outperforms Balrog. We implement it in the redshift distribution reconstruction, based on the self-organising map approach of arXiv:1509.03318, and test it using a realistic sample from the Euclid Flagship Simulation. We find that the key ingredient is to ensure that the reference objects are distributed in the colour space the same way as the wide-survey objects, which can be efficiently achieved with our transfer method. In our best implementation, the mean redshift biases are consistently reduced across the tomographic bins, bringing a significant fraction of them within the Euclid accuracy requirements in all tomographic bins. Equally importantly, the tests allow us to pinpoint which step in the calibration pipeline has the strongest impact on achieving the required accuracy. Our approach also reproduces the overall redshift distributions, which are crucial for applications such as angular clustering.

Foundation models applied to bio-molecular space hold promise to accelerate drug discovery. Molecular representation is key to building such models. Previous works have typically focused on a single representation or view of the molecules. Here, we develop a multi-view foundation model approach, that integrates molecular views of graph, image and text. Single-view foundation models are each pre-trained on a dataset of up to 200M molecules and then aggregated into combined representations. Our multi-view model is validated on a diverse set of 18 tasks, encompassing ligand-protein binding, molecular solubility, metabolism and toxicity. We show that the multi-view models perform robustly and are able to balance the strengths and weaknesses of specific views. We then apply this model to screen compounds against a large (>100 targets) set of G Protein-Coupled receptors (GPCRs). From this library of targets, we identify 33 that are related to Alzheimer's disease. On this subset, we employ our model to identify strong binders, which are validated through structure-based modeling and identification of key binding motifs.

The Circle of Willis (CoW) is an important network of arteries connecting major circulations of the brain. Its vascular architecture is believed to affect the risk, severity, and clinical outcome of serious neurovascular diseases. However, characterizing the highly variable CoW anatomy is still a manual and time-consuming expert task. The CoW is usually imaged by two non-invasive angiographic imaging modalities, magnetic resonance angiography (MRA) and computed tomography angiography (CTA), but there exist limited datasets with annotations on CoW anatomy, especially for CTA. Therefore, we organized the TopCoW challenge with the release of an annotated CoW dataset. The TopCoW dataset is the first public dataset with voxel-level annotations for 13 CoW vessel components, enabled by virtual reality technology. It is also the first large dataset using 200 pairs of MRA and CTA from the same patients. As part of the benchmark, we invited submissions worldwide and attracted over 250 registered participants from six continents. The submissions were evaluated on both internal and external test datasets of 226 scans from over five centers. The top performing teams achieved over 90% Dice scores at segmenting the CoW components, over 80% F1 scores at detecting key CoW components, and over 70% balanced accuracy at classifying CoW variants for nearly all test sets. The best algorithms also showed clinical potential in classifying fetal-type posterior cerebral artery and locating aneurysms with CoW anatomy. TopCoW demonstrated the utility and versatility of CoW segmentation algorithms for a wide range of downstream clinical applications with explainability. The annotated datasets and best performing algorithms have been released as public Zenodo records to foster further methodological development and clinical tool building.

The rapid rise of accessibility of unmanned aerial vehicles or drones pose a threat to general security and confidentiality. Most of the commercially available or custom-built drones are multi-rotors and are comprised of multiple propellers. Since these propellers rotate at a high-speed, they are generally the fastest moving parts of an image and cannot be directly "seen" by a classical camera without severe motion blur. We utilize a class of sensors that are particularly suitable for such scenarios called event cameras, which have a high temporal resolution, low-latency, and high dynamic range. In this paper, we model the geometry of a propeller and use it to generate simulated events which are used to train a deep neural network called EVPropNet to detect propellers from the data of an event camera. EVPropNet directly transfers to the real world without any fine-tuning or retraining. We present two applications of our network: (a) tracking and following an unmarked drone and (b) landing on a near-hover drone. We successfully evaluate and demonstrate the proposed approach in many real-world experiments with different propeller shapes and sizes. Our network can detect propellers at a rate of 85.1% even when 60% of the propeller is occluded and can run at upto 35Hz on a 2W power budget. To our knowledge, this is the first deep learning-based solution for detecting propellers (to detect drones). Finally, our applications also show an impressive success rate of 92% and 90% for the tracking and landing tasks respectively.

The X-ray polarization observations made possible with the Imaging X-ray Polarimetry Explorer (IXPE) offer new ways of probing high-energy emission processes in astrophysical jets from blazars. Here we report on the first X-ray polarization observation of the blazar S4 0954+65 in a high optical and X-ray state. During our multi-wavelength campaign on the source, we detected an optical flare whose peak coincided with the peak of an X-ray flare. This optical-X-ray flare most likely took place in a feature moving along the parsec-scale jet, imaged at 43 GHz by the Very Long Baseline Array. The 43 GHz polarization angle of the moving component underwent a rotation near the time of the flare. In the optical band, prior to the IXPE observation, we measured the polarization angle to be aligned with the jet axis. In contrast, during the optical flare the optical polarization angle was perpendicular to the jet axis; after the flare, it reverted to being parallel to the jet axis. Due to the smooth behavior of the optical polarization angle during the flare, we favor shocks as the main acceleration mechanism. We also infer that the ambient magnetic field lines in the jet were parallel to the jet position angle. The average degree of optical polarization during the IXPE observation was (14.3pm4.1)%. Despite the flare, we only detected an upper limit of 14% (at 3sigma level) on the X-ray polarization degree; although a reasonable assumption on the X-ray polarization angle results in an upper limit of 8.8% (3sigma). We model the spectral energy distribution (SED) and spectral polarization distribution (SPD) of S4 0954+65 with leptonic (synchrotron self-Compton) and hadronic (proton and pair synchrotron) models. The constraints we obtain with our combined multi-wavelength polarization observations and SED modeling tentatively disfavor hadronic models for the X-ray emission in S4 0954+65.

Timely and accurate lymphoma diagnosis is essential for guiding cancer treatment. Standard diagnostic practice combines hematoxylin and eosin (HE)-stained whole slide images with immunohistochemistry, flow cytometry, and molecular genetic tests to determine lymphoma subtypes, a process requiring costly equipment, skilled personnel, and causing treatment delays. Deep learning methods could assist pathologists by extracting diagnostic information from routinely available HE-stained slides, yet comprehensive benchmarks for lymphoma subtyping on multicenter data are lacking. In this work, we present the first multicenter lymphoma benchmarking dataset covering four common lymphoma subtypes and healthy control tissue. We systematically evaluate five publicly available pathology foundation models (H-optimus-1, H0-mini, Virchow2, UNI2, Titan) combined with attention-based (AB-MIL) and transformer-based (TransMIL) multiple instance learning aggregators across three magnifications (10x, 20x, 40x). On in-distribution test sets, models achieve multiclass balanced accuracies exceeding 80% across all magnifications, with all foundation models performing similarly and both aggregation methods showing comparable results. The magnification study reveals that 40x resolution is sufficient, with no performance gains from higher resolutions or cross-magnification aggregation. However, on out-of-distribution test sets, performance drops substantially to around 60%, highlighting significant generalization challenges. To advance the field, larger multicenter studies covering additional rare lymphoma subtypes are needed. We provide an automated benchmarking pipeline to facilitate such future research.

Recent large reconstruction models have made notable progress in generating high-quality 3D objects from single images. However, these methods often struggle with controllability, as they lack information from multiple views, leading to incomplete or inconsistent 3D reconstructions. To address this limitation, we introduce LucidFusion, a flexible end-to-end feed-forward framework that leverages the Relative Coordinate Map (RCM). Unlike traditional methods linking images to 3D world thorough pose, LucidFusion utilizes RCM to align geometric features coherently across different views, making it highly adaptable for 3D generation from arbitrary, unposed images. Furthermore, LucidFusion seamlessly integrates with the original single-image-to-3D pipeline, producing detailed 3D Gaussians at a resolution of 512 times 512, making it well-suited for a wide range of applications.

The rapid development of generative AI facilitates content creation and makes image manipulation easier and more difficult to detect. While multimodal Large Language Models (LLMs) have encoded rich world knowledge, they are not inherently tailored for combating AI-generated Content (AIGC) and struggle to comprehend local forgery details. In this work, we investigate the application of multimodal LLMs in forgery detection. We propose a framework capable of evaluating image authenticity, localizing tampered regions, providing evidence, and tracing generation methods based on semantic tampering clues. Our method demonstrates that the potential of LLMs in forgery analysis can be effectively unlocked through meticulous prompt engineering and the application of few-shot learning techniques. We conduct qualitative and quantitative experiments and show that GPT4V can achieve an accuracy of 92.1% in Autosplice and 86.3% in LaMa, which is competitive with state-of-the-art AIGC detection methods. We further discuss the limitations of multimodal LLMs in such tasks and propose potential improvements.

Building extraction aims to segment building pixels from remote sensing images and plays an essential role in many applications, such as city planning and urban dynamic monitoring. Over the past few years, deep learning methods with encoder-decoder architectures have achieved remarkable performance due to their powerful feature representation capability. Nevertheless, due to the varying scales and styles of buildings, conventional deep learning models always suffer from uncertain predictions and cannot accurately distinguish the complete footprints of the building from the complex distribution of ground objects, leading to a large degree of omission and commission. In this paper, we realize the importance of uncertain prediction and propose a novel and straightforward Uncertainty-Aware Network (UANet) to alleviate this problem. To verify the performance of our proposed UANet, we conduct extensive experiments on three public building datasets, including the WHU building dataset, the Massachusetts building dataset, and the Inria aerial image dataset. Results demonstrate that the proposed UANet outperforms other state-of-the-art algorithms by a large margin.

Reinforcement learning (RL) provides a principled framework for improving Vision-Language Models (VLMs) on complex reasoning tasks. However, existing RL approaches often rely on human-annotated labels or task-specific heuristics to define verifiable rewards, both of which are costly and difficult to scale. We introduce VisPlay, a self-evolving RL framework that enables VLMs to autonomously improve their reasoning abilities using large amounts of unlabeled image data. Starting from a single base VLM, VisPlay assigns the model into two interacting roles: an Image-Conditioned Questioner that formulates challenging yet answerable visual questions, and a Multimodal Reasoner that generates silver responses. These roles are jointly trained with Group Relative Policy Optimization (GRPO), which incorporates diversity and difficulty rewards to balance the complexity of generated questions with the quality of the silver answers. VisPlay scales efficiently across two model families. When trained on Qwen2.5-VL and MiMo-VL, VisPlay achieves consistent improvements in visual reasoning, compositional generalization, and hallucination reduction across eight benchmarks, including MM-Vet and MMMU, demonstrating a scalable path toward self-evolving multimodal intelligence. The project page is available at https://bruno686.github.io/VisPlay/

We present StdGEN, an innovative pipeline for generating semantically decomposed high-quality 3D characters from single images, enabling broad applications in virtual reality, gaming, and filmmaking, etc. Unlike previous methods which struggle with limited decomposability, unsatisfactory quality, and long optimization times, StdGEN features decomposability, effectiveness and efficiency; i.e., it generates intricately detailed 3D characters with separated semantic components such as the body, clothes, and hair, in three minutes. At the core of StdGEN is our proposed Semantic-aware Large Reconstruction Model (S-LRM), a transformer-based generalizable model that jointly reconstructs geometry, color and semantics from multi-view images in a feed-forward manner. A differentiable multi-layer semantic surface extraction scheme is introduced to acquire meshes from hybrid implicit fields reconstructed by our S-LRM. Additionally, a specialized efficient multi-view diffusion model and an iterative multi-layer surface refinement module are integrated into the pipeline to facilitate high-quality, decomposable 3D character generation. Extensive experiments demonstrate our state-of-the-art performance in 3D anime character generation, surpassing existing baselines by a significant margin in geometry, texture and decomposability. StdGEN offers ready-to-use semantic-decomposed 3D characters and enables flexible customization for a wide range of applications. Project page: https://stdgen.github.io

Recent studies have demonstrated the efficacy of using Reinforcement Learning (RL) in building reasoning models that articulate chains of thoughts prior to producing final answers. However, despite ongoing advances that aim at enabling reasoning for vision-language tasks, existing open-source visual reasoning models typically generate reasoning content with pure natural language, lacking explicit integration of visual information. This limits their ability to produce clearly articulated and visually grounded reasoning chains. To this end, we propose Grounded Reasoning with Images and Texts (GRIT), a novel method for training MLLMs to think with images. GRIT introduces a grounded reasoning paradigm, in which models generate reasoning chains that interleave natural language and explicit bounding box coordinates. These coordinates point to regions of the input image that the model consults during its reasoning process. Additionally, GRIT is equipped with a reinforcement learning approach, GRPO-GR, built upon the GRPO algorithm. GRPO-GR employs robust rewards focused on the final answer accuracy and format of the grounded reasoning output, which eliminates the need for data with reasoning chain annotations or explicit bounding box labels. As a result, GRIT achieves exceptional data efficiency, requiring as few as 20 image-question-answer triplets from existing datasets. Comprehensive evaluations demonstrate that GRIT effectively trains MLLMs to produce coherent and visually grounded reasoning chains, showing a successful unification of reasoning and grounding abilities.

Vision-Language Models (VLMs) have advanced multimodal understanding, yet still struggle when targets are embedded in cluttered backgrounds requiring figure-ground segregation. To address this, we introduce ChromouVQA, a large-scale, multi-task benchmark based on Ishihara-style chromatic camouflaged images. We extend classic dot plates with multiple fill geometries and vary chromatic separation, density, size, occlusion, and rotation, recording full metadata for reproducibility. The benchmark covers nine vision-question-answering tasks, including recognition, counting, comparison, and spatial reasoning. Evaluations of humans and VLMs reveal large gaps, especially under subtle chromatic contrast or disruptive geometric fills. We also propose a model-agnostic contrastive recipe aligning silhouettes with their camouflaged renderings, improving recovery of global shapes. ChromouVQA provides a compact, controlled benchmark for reproducible evaluation and extension. Code and dataset are available at https://github.com/Chromou-VQA-Benchmark/Chromou-VQA.

In this paper, we investigate the effectiveness of various LLMs in interpreting tabular data through different prompting strategies and data formats. Our analysis extends across six benchmarks for table-related tasks such as question-answering and fact-checking. We introduce for the first time the assessment of LLMs' performance on image-based table representations. Specifically, we compare five text-based and three image-based table representations, demonstrating the influence of representation and prompting on LLM performance. Our study provides insights into the effective use of LLMs on table-related tasks.

Text-to-image customization, which takes given texts and images depicting given subjects as inputs, aims to synthesize new images that align with both text semantics and subject appearance. This task provides precise control over details that text alone cannot capture and is fundamental for various real-world applications, garnering significant interest from academia and industry. Existing works follow the pseudo-word paradigm, which involves representing given subjects as pseudo-words and combining them with given texts to collectively guide the generation. However, the inherent conflict and entanglement between the pseudo-words and texts result in a dual-optimum paradox, where subject similarity and text controllability cannot be optimal simultaneously. We propose a novel real-words paradigm termed RealCustom++ that instead represents subjects as non-conflict real words, thereby disentangling subject similarity from text controllability and allowing both to be optimized simultaneously. Specifically, RealCustom++ introduces a novel "train-inference" decoupled framework: (1) During training, RealCustom++ learns the alignment between vision conditions and all real words in the text, ensuring high subject-similarity generation in open domains. This is achieved by the cross-layer cross-scale projector to robustly and finely extract subject features, and a curriculum training recipe that adapts the generated subject to diverse poses and sizes. (2) During inference, leveraging the learned general alignment, an adaptive mask guidance is proposed to only customize the generation of the specific target real word, keeping other subject-irrelevant regions uncontaminated to ensure high text-controllability in real-time.

Recent progress in multimodal reasoning has been significantly advanced by textual Chain-of-Thought (CoT), a paradigm where models conduct reasoning within language. This text-centric approach, however, treats vision as a static, initial context, creating a fundamental "semantic gap" between rich perceptual data and discrete symbolic thought. Human cognition often transcends language, utilizing vision as a dynamic mental sketchpad. A similar evolution is now unfolding in AI, marking a fundamental paradigm shift from models that merely think about images to those that can truly think with images. This emerging paradigm is characterized by models leveraging visual information as intermediate steps in their thought process, transforming vision from a passive input into a dynamic, manipulable cognitive workspace. In this survey, we chart this evolution of intelligence along a trajectory of increasing cognitive autonomy, which unfolds across three key stages: from external tool exploration, through programmatic manipulation, to intrinsic imagination. To structure this rapidly evolving field, our survey makes four key contributions. (1) We establish the foundational principles of the think with image paradigm and its three-stage framework. (2) We provide a comprehensive review of the core methods that characterize each stage of this roadmap. (3) We analyze the critical landscape of evaluation benchmarks and transformative applications. (4) We identify significant challenges and outline promising future directions. By providing this structured overview, we aim to offer a clear roadmap for future research towards more powerful and human-aligned multimodal AI.

3D AI-generated content (AIGC) is a passionate field that has significantly accelerated the creation of 3D models in gaming, film, and design. Despite the development of several groundbreaking models that have revolutionized 3D generation, the field remains largely accessible only to researchers, developers, and designers due to the complexities involved in collecting, processing, and training 3D models. To address these challenges, we introduce Hunyuan3D 2.1 as a case study in this tutorial. This tutorial offers a comprehensive, step-by-step guide on processing 3D data, training a 3D generative model, and evaluating its performance using Hunyuan3D 2.1, an advanced system for producing high-resolution, textured 3D assets. The system comprises two core components: the Hunyuan3D-DiT for shape generation and the Hunyuan3D-Paint for texture synthesis. We will explore the entire workflow, including data preparation, model architecture, training strategies, evaluation metrics, and deployment. By the conclusion of this tutorial, you will have the knowledge to finetune or develop a robust 3D generative model suitable for applications in gaming, virtual reality, and industrial design.

Pretrained vision-language models (VLMs) such as CLIP excel in general multimodal comprehension but often struggle to capture nuanced, context-dependent visual cues. This makes it difficult to distinguish between similar-looking concepts with potentially different cultural meanings. Such deficiencies are mainly due to a limited amount of high-quality cultural data, contextual information, and the lack of negative examples that highlight subtle differences. To mitigate this, we design a data curation pipeline leveraging open-sourced VLMs and text-to-image models to construct CulTwin, a synthetic cultural dataset. This dataset consists of paired concept-caption-image triplets, where concepts visually resemble each other but are culturally different. Then, we fine-tune CLIP on CulTwin to develop CultureCLIP, which aligns cultural concepts with contextually enhanced captions and synthetic images through tailored contrastive learning. Experiments on culture-specific benchmarks show that CultureCLIP outperforms the base CLIP, achieving up to a notable 5.49% improvement in fine-grained concept recognition on certain tasks while preserving CLIP's original generalization ability, validating the effectiveness of our data synthesis and VLM backbone training paradigm in capturing subtle cultural distinctions.

Dataset distillation and dataset pruning are two prominent techniques for compressing datasets to improve computational and storage efficiency. Despite their overlapping objectives, these approaches are rarely compared directly. Even within each field, the evaluation protocols are inconsistent across various methods, which complicates fair comparisons and hinders reproducibility. Considering these limitations, we introduce in this paper a benchmark that equitably evaluates methodologies across both distillation and pruning literatures. Notably, our benchmark reveals that in the mainstream dataset distillation setting for large-scale datasets, which heavily rely on soft labels from pre-trained models, even randomly selected subsets can achieve surprisingly competitive performance. This finding suggests that an overemphasis on soft labels may be diverting attention from the intrinsic value of the image data, while also imposing additional burdens in terms of generation, storage, and application. To address these issues, we propose a new framework for dataset compression, termed Prune, Combine, and Augment (PCA), which focuses on leveraging image data exclusively, relies solely on hard labels for evaluation, and achieves state-of-the-art performance in this setup. By shifting the emphasis back to the images, our benchmark and PCA framework pave the way for more balanced and accessible techniques in dataset compression research. Our code is available at: https://github.com/ArmandXiao/Rethinking-Dataset-Compression

State-of-the-art Text-to-Image models like Stable Diffusion and DALLEcdot2 are revolutionizing how people generate visual content. At the same time, society has serious concerns about how adversaries can exploit such models to generate unsafe images. In this work, we focus on demystifying the generation of unsafe images and hateful memes from Text-to-Image models. We first construct a typology of unsafe images consisting of five categories (sexually explicit, violent, disturbing, hateful, and political). Then, we assess the proportion of unsafe images generated by four advanced Text-to-Image models using four prompt datasets. We find that these models can generate a substantial percentage of unsafe images; across four models and four prompt datasets, 14.56% of all generated images are unsafe. When comparing the four models, we find different risk levels, with Stable Diffusion being the most prone to generating unsafe content (18.92% of all generated images are unsafe). Given Stable Diffusion's tendency to generate more unsafe content, we evaluate its potential to generate hateful meme variants if exploited by an adversary to attack a specific individual or community. We employ three image editing methods, DreamBooth, Textual Inversion, and SDEdit, which are supported by Stable Diffusion. Our evaluation result shows that 24% of the generated images using DreamBooth are hateful meme variants that present the features of the original hateful meme and the target individual/community; these generated images are comparable to hateful meme variants collected from the real world. Overall, our results demonstrate that the danger of large-scale generation of unsafe images is imminent. We discuss several mitigating measures, such as curating training data, regulating prompts, and implementing safety filters, and encourage better safeguard tools to be developed to prevent unsafe generation.

In an era where images and visual content dominate our digital landscape, the ability to manipulate and personalize these images has become a necessity. Envision seamlessly substituting a tabby cat lounging on a sunlit window sill in a photograph with your own playful puppy, all while preserving the original charm and composition of the image. We present Photoswap, a novel approach that enables this immersive image editing experience through personalized subject swapping in existing images. Photoswap first learns the visual concept of the subject from reference images and then swaps it into the target image using pre-trained diffusion models in a training-free manner. We establish that a well-conceptualized visual subject can be seamlessly transferred to any image with appropriate self-attention and cross-attention manipulation, maintaining the pose of the swapped subject and the overall coherence of the image. Comprehensive experiments underscore the efficacy and controllability of Photoswap in personalized subject swapping. Furthermore, Photoswap significantly outperforms baseline methods in human ratings across subject swapping, background preservation, and overall quality, revealing its vast application potential, from entertainment to professional editing.

While diffusion models have revolutionized text-to-image generation with their ability to synthesize realistic and diverse scenes, they continue to struggle to generate consistent and legible text within images. This shortcoming is commonly attributed to the locality bias inherent in diffusion-based generation, which limits their ability to model long-range spatial dependencies. In this paper, we introduce STRICT, a benchmark designed to systematically stress-test the ability of diffusion models to render coherent and instruction-aligned text in images. Our benchmark evaluates models across multiple dimensions: (1) the maximum length of readable text that can be generated; (2) the correctness and legibility of the generated text, and (3) the ratio of not following instructions for generating text. We evaluate several state-of-the-art models, including proprietary and open-source variants, and reveal persistent limitations in long-range consistency and instruction-following capabilities. Our findings provide insights into architectural bottlenecks and motivate future research directions in multimodal generative modeling. We release our entire evaluation pipeline at https://github.com/tianyu-z/STRICT-Bench.

While recent multimodal large language models (MLLMs) have advanced automated ECG interpretation, they still face two key limitations: (1) insufficient multimodal synergy between time series signals and visual ECG representations, and (2) limited explainability in linking diagnoses to granular waveform evidence. We introduce GEM, the first MLLM unifying ECG time series, 12-lead ECG images and text for grounded and clinician-aligned ECG interpretation. GEM enables feature-grounded analysis, evidence-driven reasoning, and a clinician-like diagnostic process through three core innovations: a dual-encoder framework extracting complementary time series and image features, cross-modal alignment for effective multimodal understanding, and knowledge-guided instruction generation for generating high-granularity grounding data (ECG-Grounding) linking diagnoses to measurable parameters (e.g., QRS/PR Intervals). Additionally, we propose the Grounded ECG Understanding task, a clinically motivated benchmark designed to comprehensively assess the MLLM's capability in grounded ECG understanding. Experimental results on both existing and our proposed benchmarks show GEM significantly improves predictive performance (CSN 7.4% uparrow), explainability (22.7% uparrow), and grounding (24.8% uparrow), making it more suitable for real-world clinical applications. GitHub repository: https://github.com/lanxiang1017/GEM.git

While current face animation methods can manipulate expressions individually, they suffer from several limitations. The expressions manipulated by some motion-based facial reenactment models are crude. Other ideas modeled with facial action units cannot generalize to arbitrary expressions not covered by annotations. In this paper, we introduce a novel Geometry-aware Facial Expression Translation (GaFET) framework, which is based on parametric 3D facial representations and can stably decoupled expression. Among them, a Multi-level Feature Aligned Transformer is proposed to complement non-geometric facial detail features while addressing the alignment challenge of spatial features. Further, we design a De-expression model based on StyleGAN, in order to reduce the learning difficulty of GaFET in unpaired "in-the-wild" images. Extensive qualitative and quantitative experiments demonstrate that we achieve higher-quality and more accurate facial expression transfer results compared to state-of-the-art methods, and demonstrate applicability of various poses and complex textures. Besides, videos or annotated training data are omitted, making our method easier to use and generalize.

Image-text interleaved data, consisting of multiple images and texts arranged in a natural document format, aligns with the presentation paradigm of internet data and closely resembles human reading habits. Recent studies have shown that such data aids multimodal in-context learning and maintains the capabilities of large language models during multimodal fine-tuning. However, the limited scale and diversity of current image-text interleaved data restrict the development of multimodal large language models. In this paper, we introduce OmniCorpus, a 10 billion-scale image-text interleaved dataset. Using an efficient data engine, we filter and extract large-scale high-quality documents, which contain 8.6 billion images and 1,696 billion text tokens. Compared to counterparts (e.g., MMC4, OBELICS), our dataset 1) has 15 times larger scales while maintaining good data quality; 2) features more diverse sources, including both English and non-English websites as well as video-centric websites; 3) is more flexible, easily degradable from an image-text interleaved format to pure text corpus and image-text pairs. Through comprehensive analysis and experiments, we validate the quality, usability, and effectiveness of the proposed dataset. We hope this could provide a solid data foundation for future multimodal model research. Code and data are released at https://github.com/OpenGVLab/OmniCorpus.

Recently, GPT-4o has garnered significant attention for its strong performance in image generation, yet open-source models still lag behind. Several studies have explored distilling image data from GPT-4o to enhance open-source models, achieving notable progress. However, a key question remains: given that real-world image datasets already constitute a natural source of high-quality data, why should we use GPT-4o-generated synthetic data? In this work, we identify two key advantages of synthetic images. First, they can complement rare scenarios in real-world datasets, such as surreal fantasy or multi-reference image generation, which frequently occur in user queries. Second, they provide clean and controllable supervision. Real-world data often contains complex background noise and inherent misalignment between text descriptions and image content, whereas synthetic images offer pure backgrounds and long-tailed supervision signals, facilitating more accurate text-to-image alignment. Building on these insights, we introduce Echo-4o-Image, a 180K-scale synthetic dataset generated by GPT-4o, harnessing the power of synthetic image data to address blind spots in real-world coverage. Using this dataset, we fine-tune the unified multimodal generation baseline Bagel to obtain Echo-4o. In addition, we propose two new evaluation benchmarks for a more accurate and challenging assessment of image generation capabilities: GenEval++, which increases instruction complexity to mitigate score saturation, and Imagine-Bench, which focuses on evaluating both the understanding and generation of imaginative content. Echo-4o demonstrates strong performance across standard benchmarks. Moreover, applying Echo-4o-Image to other foundation models (e.g., OmniGen2, BLIP3-o) yields consistent performance gains across multiple metrics, highlighting the datasets strong transferability.

Recent multimodal reasoning models, inspired by DeepSeek-R1, have significantly advanced vision-language systems. However, in remote sensing (RS) tasks, we observe widespread pseudo reasoning: models narrate the process of reasoning rather than genuinely reason toward the correct answer based on visual evidence. We attribute this to the Glance Effect, where a single, coarse perception of large-scale RS imagery results in incomplete understanding and reasoning based on linguistic self-consistency instead of visual evidence. To address this, we propose RS-EoT (Remote Sensing Evidence-of-Thought), a language-driven, iterative visual evidence-seeking paradigm. To instill this paradigm, we propose SocraticAgent, a self-play multi-agent system that synthesizes reasoning traces via alternating cycles of reasoning and visual inspection. To enhance and generalize these patterns, we propose a two-stage progressive RL strategy: first, RL on fine-grained Grounding tasks to enhance RS-EoT capabilities, followed by RL on RS VQA to generalize to broader understanding scenarios. Experiments show RS-EoT achieves state-of-the-art performance on multiple RS VQA and grounding benchmarks. Analyses reveal clear iterative cycles of reasoning and evidence seeking, confirming RS-EoT mitigates the Glance Effect and enables genuine evidence-grounded reasoning. Our code, data, and models are available at https://geox-lab.github.io/Asking_like_Socrates

High-resolution segmentation is critical for precise disease diagnosis by extracting fine-grained morphological details. Existing hierarchical encoder-decoder frameworks have demonstrated remarkable adaptability across diverse medical segmentation tasks. While beneficial, they usually require the huge computation and memory cost when handling large-size segmentation, which limits their applications in foundation model building and real-world clinical scenarios. To address this limitation, we propose a holistically efficient framework for high-resolution medical image segmentation, called HER-Seg. Specifically, we first devise a computation-efficient image encoder (CE-Encoder) to model long-range dependencies with linear complexity while maintaining sufficient representations. In particular, we introduce the dual-gated linear attention (DLA) mechanism to perform cascaded token filtering, selectively retaining important tokens while ignoring irrelevant ones to enhance attention computation efficiency. Then, we introduce a memory-efficient mask decoder (ME-Decoder) to eliminate the demand for the hierarchical structure by leveraging cross-scale segmentation decoding. Extensive experiments reveal that HER-Seg outperforms state-of-the-arts in high-resolution medical 2D, 3D and video segmentation tasks. In particular, our HER-Seg requires only 0.59GB training GPU memory and 9.39G inference FLOPs per 1024times1024 image, demonstrating superior memory and computation efficiency. The code is available at https://github.com/xq141839/HER-Seg.

The rapid advancement of deep learning has facilitated the automated processing of electron microscopy (EM) big data stacks. However, designing a framework that eliminates manual labeling and adapts to domain gaps remains challenging. Current research remains entangled in the dilemma of pursuing complete automation while still requiring simulations or slight manual annotations. Here we demonstrate tandem generative adversarial network (tGAN), a fully label-free and simulation-free pipeline capable of generating EM images for computer vision training. The tGAN can assimilate key features from new data stacks, thus producing a tailored virtual dataset for the training of automated EM analysis tools. Using segmenting nanoparticles for analyzing size distribution of supported catalysts as the demonstration, our findings showcased that the recognition accuracy of tGAN even exceeds the manually-labeling method by 5%. It can also be adaptively deployed to various data domains without further manual manipulation, which is verified by transfer learning from HAADF-STEM to BF-TEM. This generalizability may enable it to extend its application to a broader range of imaging characterizations, liberating microscopists and materials scientists from tedious dataset annotations.

Existing volumetric medical image segmentation models are typically task-specific, excelling at specific target but struggling to generalize across anatomical structures or modalities. This limitation restricts their broader clinical use. In this paper, we introduce SAM-Med3D for general-purpose segmentation on volumetric medical images. Given only a few 3D prompt points, SAM-Med3D can accurately segment diverse anatomical structures and lesions across various modalities. To achieve this, we gather and process a large-scale 3D medical image dataset, SA-Med3D-140K, from a blend of public sources and licensed private datasets. This dataset includes 22K 3D images and 143K corresponding 3D masks. Then SAM-Med3D, a promptable segmentation model characterized by the fully learnable 3D structure, is trained on this dataset using a two-stage procedure and exhibits impressive performance on both seen and unseen segmentation targets. We comprehensively evaluate SAM-Med3D on 16 datasets covering diverse medical scenarios, including different anatomical structures, modalities, targets, and zero-shot transferability to new/unseen tasks. The evaluation shows the efficiency and efficacy of SAM-Med3D, as well as its promising application to diverse downstream tasks as a pre-trained model. Our approach demonstrates that substantial medical resources can be utilized to develop a general-purpose medical AI for various potential applications. Our dataset, code, and models are available at https://github.com/uni-medical/SAM-Med3D.

Coronary artery disease (CAD) is a leading cause of cardiovascular-related mortality, and accurate stenosis detection is crucial for effective clinical decision-making. Coronary angiography remains the gold standard for diagnosing CAD, but manual analysis of angiograms is prone to errors and subjectivity. This study aims to develop a deep learning-based approach for the automatic segmentation of coronary arteries from angiographic images and the quantitative detection of stenosis, thereby improving the accuracy and efficiency of CAD diagnosis. We propose a novel deep learning-based method for the automatic segmentation of coronary arteries in angiographic images, coupled with a dynamic cohort method for stenosis detection. The segmentation model combines the MedSAM and VM-UNet architectures to achieve high-performance results. After segmentation, the vascular centerline is extracted, vessel diameter is computed, and the degree of stenosis is measured with high precision, enabling accurate identification of arterial stenosis. On the mixed dataset (including the ARCADE, DCA1, and GH datasets), the model achieved an average IoU of 0.6308, with sensitivity and specificity of 0.9772 and 0.9903, respectively. On the ARCADE dataset, the average IoU was 0.6303, with sensitivity of 0.9832 and specificity of 0.9933. Additionally, the stenosis detection algorithm achieved a true positive rate (TPR) of 0.5867 and a positive predictive value (PPV) of 0.5911, demonstrating the effectiveness of our model in analyzing coronary angiography images. SAM-VMNet offers a promising tool for the automated segmentation and detection of coronary artery stenosis. The model's high accuracy and robustness provide significant clinical value for the early diagnosis and treatment planning of CAD. The code and examples are available at https://github.com/qimingfan10/SAM-VMNet.

Foundation models have demonstrated remarkable potential in medical domain. However, their application to complex cardiovascular diagnostics remains underexplored. In this paper, we present Cardiac-CLIP, a multi-modal foundation model designed for 3D cardiac CT images. Cardiac-CLIP is developed through a two-stage pre-training strategy. The first stage employs a 3D masked autoencoder (MAE) to perform self-supervised representation learning from large-scale unlabeled volumetric data, enabling the visual encoder to capture rich anatomical and contextual features. In the second stage, contrastive learning is introduced to align visual and textual representations, facilitating cross-modal understanding. To support the pre-training, we collect 16641 real clinical CT scans, supplemented by 114k publicly available data. Meanwhile, we standardize free-text radiology reports into unified templates and construct the pathology vectors according to diagnostic attributes, based on which the soft-label matrix is generated to supervise the contrastive learning process. On the other hand, to comprehensively evaluate the effectiveness of Cardiac-CLIP, we collect 6,722 real-clinical data from 12 independent institutions, along with the open-source data to construct the evaluation dataset. Specifically, Cardiac-CLIP is comprehensively evaluated across multiple tasks, including cardiovascular abnormality classification, information retrieval and clinical analysis. Experimental results demonstrate that Cardiac-CLIP achieves state-of-the-art performance across various downstream tasks in both internal and external data. Particularly, Cardiac-CLIP exhibits great effectiveness in supporting complex clinical tasks such as the prospective prediction of acute coronary syndrome, which is notoriously difficult in real-world scenarios.

The scarcity of high-quality, labelled retinal imaging data, which presents a significant challenge in the development of machine learning models for ophthalmology, hinders progress in the field. Existing methods for synthesising Colour Fundus Photographs (CFPs) largely rely on predefined disease labels, which restricts their ability to generate images that reflect fine-grained anatomical variations, subtle disease stages, and diverse pathological features beyond coarse class categories. To overcome these challenges, we first introduce an innovative pipeline that creates a large-scale, captioned retinal dataset comprising 1.4 million entries, called RetinaLogos-1400k. Specifically, RetinaLogos-1400k uses the visual language model(VLM) to describe retinal conditions and key structures, such as optic disc configuration, vascular distribution, nerve fibre layers, and pathological features. Building on this dataset, we employ a novel three-step training framework, RetinaLogos, which enables fine-grained semantic control over retinal images and accurately captures different stages of disease progression, subtle anatomical variations, and specific lesion types. Through extensive experiments, our method demonstrates superior performance across multiple datasets, with 62.07% of text-driven synthetic CFPs indistinguishable from real ones by ophthalmologists. Moreover, the synthetic data improves accuracy by 5%-10% in diabetic retinopathy grading and glaucoma detection. Codes are available at https://github.com/uni-medical/retina-text2cfp.

Medical image segmentation and video object segmentation are essential for diagnosing and analyzing diseases by identifying and measuring biological structures. Recent advances in natural domain have been driven by foundation models like the Segment Anything Model 2 (SAM 2). To explore the performance of SAM 2 in biomedical applications, we designed two evaluation pipelines for single-frame image segmentation and multi-frame video segmentation with varied prompt designs, revealing SAM 2's limitations in medical contexts. Consequently, we developed BioSAM 2, an enhanced foundation model optimized for biomedical data based on SAM 2. Our experiments show that BioSAM 2 not only surpasses the performance of existing state-of-the-art foundation models but also matches or even exceeds specialist models, demonstrating its efficacy and potential in the medical domain.

Personalized image generation with text-to-image diffusion models generates unseen images based on reference image content. Zero-shot adapter methods such as IP-Adapter and OminiControl are especially interesting because they do not require test-time fine-tuning. However, they struggle to balance preserving personalized content and adherence to the text prompt. We identify a critical design flaw resulting in this performance gap: current adapters inadequately integrate personalization images with the textual descriptions. The generated images, therefore, replicate the personalized content rather than adhere to the text prompt instructions. Yet the base text-to-image has strong conceptual understanding capabilities that can be leveraged. We propose Conceptrol, a simple yet effective framework that enhances zero-shot adapters without adding computational overhead. Conceptrol constrains the attention of visual specification with a textual concept mask that improves subject-driven generation capabilities. It achieves as much as 89% improvement on personalization benchmarks over the vanilla IP-Adapter and can even outperform fine-tuning approaches such as Dreambooth LoRA. The source code is available at https://github.com/QY-H00/Conceptrol.

In this work, we investigate the capability of generating images from pre-trained diffusion models at much higher resolutions than the training image sizes. In addition, the generated images should have arbitrary image aspect ratios. When generating images directly at a higher resolution, 1024 x 1024, with the pre-trained Stable Diffusion using training images of resolution 512 x 512, we observe persistent problems of object repetition and unreasonable object structures. Existing works for higher-resolution generation, such as attention-based and joint-diffusion approaches, cannot well address these issues. As a new perspective, we examine the structural components of the U-Net in diffusion models and identify the crucial cause as the limited perception field of convolutional kernels. Based on this key observation, we propose a simple yet effective re-dilation that can dynamically adjust the convolutional perception field during inference. We further propose the dispersed convolution and noise-damped classifier-free guidance, which can enable ultra-high-resolution image generation (e.g., 4096 x 4096). Notably, our approach does not require any training or optimization. Extensive experiments demonstrate that our approach can address the repetition issue well and achieve state-of-the-art performance on higher-resolution image synthesis, especially in texture details. Our work also suggests that a pre-trained diffusion model trained on low-resolution images can be directly used for high-resolution visual generation without further tuning, which may provide insights for future research on ultra-high-resolution image and video synthesis.

Introducing user-specified visual concepts in image editing is highly practical as these concepts convey the user's intent more precisely than text-based descriptions. We propose FreeEdit, a novel approach for achieving such reference-based image editing, which can accurately reproduce the visual concept from the reference image based on user-friendly language instructions. Our approach leverages the multi-modal instruction encoder to encode language instructions to guide the editing process. This implicit way of locating the editing area eliminates the need for manual editing masks. To enhance the reconstruction of reference details, we introduce the Decoupled Residual ReferAttention (DRRA) module. This module is designed to integrate fine-grained reference features extracted by a detail extractor into the image editing process in a residual way without interfering with the original self-attention. Given that existing datasets are unsuitable for reference-based image editing tasks, particularly due to the difficulty in constructing image triplets that include a reference image, we curate a high-quality dataset, FreeBench, using a newly developed twice-repainting scheme. FreeBench comprises the images before and after editing, detailed editing instructions, as well as a reference image that maintains the identity of the edited object, encompassing tasks such as object addition, replacement, and deletion. By conducting phased training on FreeBench followed by quality tuning, FreeEdit achieves high-quality zero-shot editing through convenient language instructions. We conduct extensive experiments to evaluate the effectiveness of FreeEdit across multiple task types, demonstrating its superiority over existing methods. The code will be available at: https://freeedit.github.io/.

Domain generalization (DG) for object detection aims to enhance detectors' performance in unseen scenarios. This task remains challenging due to complex variations in real-world applications. Recently, diffusion models have demonstrated remarkable capabilities in diverse scene generation, which inspires us to explore their potential for improving DG tasks. Instead of generating images, our method extracts multi-step intermediate features during the diffusion process to obtain domain-invariant features for generalized detection. Furthermore, we propose an efficient knowledge transfer framework that enables detectors to inherit the generalization capabilities of diffusion models through feature and object-level alignment, without increasing inference time. We conduct extensive experiments on six challenging DG benchmarks. The results demonstrate that our method achieves substantial improvements of 14.0% mAP over existing DG approaches across different domains and corruption types. Notably, our method even outperforms most domain adaptation methods without accessing any target domain data. Moreover, the diffusion-guided detectors show consistent improvements of 15.9% mAP on average compared to the baseline. Our work aims to present an effective approach for domain-generalized detection and provide potential insights for robust visual recognition in real-world scenarios. The code is available at https://github.com/heboyong/Generalized-Diffusion-Detector.

Foundation models for interactive segmentation in 2D natural images and videos have sparked significant interest in building 3D foundation models for medical imaging. However, the domain gaps and clinical use cases for 3D medical imaging require a dedicated model that diverges from existing 2D solutions. Specifically, such foundation models should support a full workflow that can actually reduce human effort. Treating 3D medical images as sequences of 2D slices and reusing interactive 2D foundation models seems straightforward, but 2D annotation is too time-consuming for 3D tasks. Moreover, for large cohort analysis, it's the highly accurate automatic segmentation models that reduce the most human effort. However, these models lack support for interactive corrections and lack zero-shot ability for novel structures, which is a key feature of "foundation". While reusing pre-trained 2D backbones in 3D enhances zero-shot potential, their performance on complex 3D structures still lags behind leading 3D models. To address these issues, we present VISTA3D, Versatile Imaging SegmenTation and Annotation model, that targets to solve all these challenges and requirements with one unified foundation model. VISTA3D is built on top of the well-established 3D segmentation pipeline, and it is the first model to achieve state-of-the-art performance in both 3D automatic (supporting 127 classes) and 3D interactive segmentation, even when compared with top 3D expert models on large and diverse benchmarks. Additionally, VISTA3D's 3D interactive design allows efficient human correction, and a novel 3D supervoxel method that distills 2D pretrained backbones grants VISTA3D top 3D zero-shot performance. We believe the model, recipe, and insights represent a promising step towards a clinically useful 3D foundation model. Code and weights are publicly available at https://github.com/Project-MONAI/VISTA.

Recent text-to-image generation models have shown promising results in generating high-fidelity photo-realistic images. Though the results are astonishing to human eyes, how applicable these generated images are for recognition tasks remains under-explored. In this work, we extensively study whether and how synthetic images generated from state-of-the-art text-to-image generation models can be used for image recognition tasks, and focus on two perspectives: synthetic data for improving classification models in data-scarce settings (i.e. zero-shot and few-shot), and synthetic data for large-scale model pre-training for transfer learning. We showcase the powerfulness and shortcomings of synthetic data from existing generative models, and propose strategies for better applying synthetic data for recognition tasks. Code: https://github.com/CVMI-Lab/SyntheticData.

Existing deep convolutional neural networks (CNNs) require a fixed-size (e.g., 224x224) input image. This requirement is "artificial" and may reduce the recognition accuracy for the images or sub-images of an arbitrary size/scale. In this work, we equip the networks with another pooling strategy, "spatial pyramid pooling", to eliminate the above requirement. The new network structure, called SPP-net, can generate a fixed-length representation regardless of image size/scale. Pyramid pooling is also robust to object deformations. With these advantages, SPP-net should in general improve all CNN-based image classification methods. On the ImageNet 2012 dataset, we demonstrate that SPP-net boosts the accuracy of a variety of CNN architectures despite their different designs. On the Pascal VOC 2007 and Caltech101 datasets, SPP-net achieves state-of-the-art classification results using a single full-image representation and no fine-tuning. The power of SPP-net is also significant in object detection. Using SPP-net, we compute the feature maps from the entire image only once, and then pool features in arbitrary regions (sub-images) to generate fixed-length representations for training the detectors. This method avoids repeatedly computing the convolutional features. In processing test images, our method is 24-102x faster than the R-CNN method, while achieving better or comparable accuracy on Pascal VOC 2007. In ImageNet Large Scale Visual Recognition Challenge (ILSVRC) 2014, our methods rank #2 in object detection and #3 in image classification among all 38 teams. This manuscript also introduces the improvement made for this competition.

Recovering the geometry and materials of objects from a single image is challenging due to its under-constrained nature. In this paper, we present Neural LightRig, a novel framework that boosts intrinsic estimation by leveraging auxiliary multi-lighting conditions from 2D diffusion priors. Specifically, 1) we first leverage illumination priors from large-scale diffusion models to build our multi-light diffusion model on a synthetic relighting dataset with dedicated designs. This diffusion model generates multiple consistent images, each illuminated by point light sources in different directions. 2) By using these varied lighting images to reduce estimation uncertainty, we train a large G-buffer model with a U-Net backbone to accurately predict surface normals and materials. Extensive experiments validate that our approach significantly outperforms state-of-the-art methods, enabling accurate surface normal and PBR material estimation with vivid relighting effects. Code and dataset are available on our project page at https://projects.zxhezexin.com/neural-lightrig.

We present GazeGen, a user interaction system that generates visual content (images and videos) for locations indicated by the user's eye gaze. GazeGen allows intuitive manipulation of visual content by targeting regions of interest with gaze. Using advanced techniques in object detection and generative AI, GazeGen performs gaze-controlled image adding/deleting, repositioning, and surface material changes of image objects, and converts static images into videos. Central to GazeGen is the DFT Gaze (Distilled and Fine-Tuned Gaze) agent, an ultra-lightweight model with only 281K parameters, performing accurate real-time gaze predictions tailored to individual users' eyes on small edge devices. GazeGen is the first system to combine visual content generation with real-time gaze estimation, made possible exclusively by DFT Gaze. This real-time gaze estimation enables various visual content generation tasks, all controlled by the user's gaze. The input for DFT Gaze is the user's eye images, while the inputs for visual content generation are the user's view and the predicted gaze point from DFT Gaze. To achieve efficient gaze predictions, we derive the small model from a large model (10x larger) via novel knowledge distillation and personal adaptation techniques. We integrate knowledge distillation with a masked autoencoder, developing a compact yet powerful gaze estimation model. This model is further fine-tuned with Adapters, enabling highly accurate and personalized gaze predictions with minimal user input. DFT Gaze ensures low-latency and precise gaze tracking, supporting a wide range of gaze-driven tasks. We validate the performance of DFT Gaze on AEA and OpenEDS2020 benchmarks, demonstrating low angular gaze error and low latency on the edge device (Raspberry Pi 4). Furthermore, we describe applications of GazeGen, illustrating its versatility and effectiveness in various usage scenarios.

Modern music producers commonly use MIDI (Musical Instrument Digital Interface) to store their musical compositions. However, MIDI files created with digital software may lack the expressive characteristics of human performances, essentially leaving the velocity parameter - a control for note loudness - undefined, which defaults to a flat value. The task of filling MIDI velocity is termed MIDI velocity prediction, which uses regression models to enhance music expressiveness by adjusting only this parameter. In this paper, we introduce the U-Net, a widely adopted architecture in image colorization, to this task. By conceptualizing MIDI data as images, we adopt window attention and develop a custom loss function to address the sparsity of MIDI-converted images. Current dataset availability restricts our experiments to piano data. Evaluated on the MAESTRO v3 and SMD datasets, our proposed method for filling MIDI velocity outperforms previous approaches in both quantitative metrics and qualitative listening tests.

Dynamic scene video deblurring aims to remove undesirable blurry artifacts captured during the exposure process. Although previous video deblurring methods have achieved impressive results, they suffer from significant performance drops due to the domain gap between training and testing videos, especially for those captured in real-world scenarios. To address this issue, we propose a domain adaptation scheme based on a blurring model to achieve test-time fine-tuning for deblurring models in unseen domains. Since blurred and sharp pairs are unavailable for fine-tuning during inference, our scheme can generate domain-adaptive training pairs to calibrate a deblurring model for the target domain. First, a Relative Sharpness Detection Module is proposed to identify relatively sharp regions from the blurry input images and regard them as pseudo-sharp images. Next, we utilize a blurring model to produce blurred images based on the pseudo-sharp images extracted during testing. To synthesize blurred images in compliance with the target data distribution, we propose a Domain-adaptive Blur Condition Generation Module to create domain-specific blur conditions for the blurring model. Finally, the generated pseudo-sharp and blurred pairs are used to fine-tune a deblurring model for better performance. Extensive experimental results demonstrate that our approach can significantly improve state-of-the-art video deblurring methods, providing performance gains of up to 7.54dB on various real-world video deblurring datasets. The source code is available at https://github.com/Jin-Ting-He/DADeblur.

The rapid advances in generative AI models have empowered the creation of highly realistic images with arbitrary content, raising concerns about potential misuse and harm, such as Deepfakes. Current research focuses on training detectors using large datasets of generated images. However, these training-based solutions are often computationally expensive and show limited generalization to unseen generated images. In this paper, we propose a training-free method to distinguish between real and AI-generated images. We first observe that real images are more robust to tiny noise perturbations than AI-generated images in the representation space of vision foundation models. Based on this observation, we propose RIGID, a training-free and model-agnostic method for robust AI-generated image detection. RIGID is a simple yet effective approach that identifies whether an image is AI-generated by comparing the representation similarity between the original and the noise-perturbed counterpart. Our evaluation on a diverse set of AI-generated images and benchmarks shows that RIGID significantly outperforms existing trainingbased and training-free detectors. In particular, the average performance of RIGID exceeds the current best training-free method by more than 25%. Importantly, RIGID exhibits strong generalization across different image generation methods and robustness to image corruptions.

Conditional diffusion models can create unseen images in various settings, aiding image interpolation. Interpolation in latent spaces is well-studied, but interpolation with specific conditions like text or poses is less understood. Simple approaches, such as linear interpolation in the space of conditions, often result in images that lack consistency, smoothness, and fidelity. To that end, we introduce a novel training-free technique named Attention Interpolation via Diffusion (AID). Our key contributions include 1) proposing an inner/outer interpolated attention layer; 2) fusing the interpolated attention with self-attention to boost fidelity; and 3) applying beta distribution to selection to increase smoothness. We also present a variant, Prompt-guided Attention Interpolation via Diffusion (PAID), that considers interpolation as a condition-dependent generative process. This method enables the creation of new images with greater consistency, smoothness, and efficiency, and offers control over the exact path of interpolation. Our approach demonstrates effectiveness for conceptual and spatial interpolation. Code and demo are available at https://github.com/QY-H00/attention-interpolation-diffusion.

Gaze redirection is the task of changing the gaze to a desired direction for a given monocular eye patch image. Many applications such as videoconferencing, films, games, and generation of training data for gaze estimation require redirecting the gaze, without distorting the appearance of the area surrounding the eye and while producing photo-realistic images. Existing methods lack the ability to generate perceptually plausible images. In this work, we present a novel method to alleviate this problem by leveraging generative adversarial training to synthesize an eye image conditioned on a target gaze direction. Our method ensures perceptual similarity and consistency of synthesized images to the real images. Furthermore, a gaze estimation loss is used to control the gaze direction accurately. To attain high-quality images, we incorporate perceptual and cycle consistency losses into our architecture. In extensive evaluations we show that the proposed method outperforms state-of-the-art approaches in terms of both image quality and redirection precision. Finally, we show that generated images can bring significant improvement for the gaze estimation task if used to augment real training data.

This paper studies the problem of generalized zero-shot learning which requires the model to train on image-label pairs from some seen classes and test on the task of classifying new images from both seen and unseen classes. Most previous models try to learn a fixed one-directional mapping between visual and semantic space, while some recently proposed generative methods try to generate image features for unseen classes so that the zero-shot learning problem becomes a traditional fully-supervised classification problem. In this paper, we propose a novel model that provides a unified framework for three different approaches: visual-> semantic mapping, semantic->visual mapping, and metric learning. Specifically, our proposed model consists of a feature generator that can generate various visual features given class embeddings as input, a regressor that maps each visual feature back to its corresponding class embedding, and a discriminator that learns to evaluate the closeness of an image feature and a class embedding. All three components are trained under the combination of cyclic consistency loss and dual adversarial loss. Experimental results show that our model not only preserves higher accuracy in classifying images from seen classes, but also performs better than existing state-of-the-art models in in classifying images from unseen classes.

This paper enables high-fidelity, transferable NeRF editing by frequency decomposition. Recent NeRF editing pipelines lift 2D stylization results to 3D scenes while suffering from blurry results, and fail to capture detailed structures caused by the inconsistency between 2D editings. Our critical insight is that low-frequency components of images are more multiview-consistent after editing compared with their high-frequency parts. Moreover, the appearance style is mainly exhibited on the low-frequency components, and the content details especially reside in high-frequency parts. This motivates us to perform editing on low-frequency components, which results in high-fidelity edited scenes. In addition, the editing is performed in the low-frequency feature space, enabling stable intensity control and novel scene transfer. Comprehensive experiments conducted on photorealistic datasets demonstrate the superior performance of high-fidelity and transferable NeRF editing. The project page is at https://aigc3d.github.io/freditor.

In this paper, we propose ZipAR, a training-free, plug-and-play parallel decoding framework for accelerating auto-regressive (AR) visual generation. The motivation stems from the observation that images exhibit local structures, and spatially distant regions tend to have minimal interdependence. Given a partially decoded set of visual tokens, in addition to the original next-token prediction scheme in the row dimension, the tokens corresponding to spatially adjacent regions in the column dimension can be decoded in parallel, enabling the ``next-set prediction'' paradigm. By decoding multiple tokens simultaneously in a single forward pass, the number of forward passes required to generate an image is significantly reduced, resulting in a substantial improvement in generation efficiency. Experiments demonstrate that ZipAR can reduce the number of model forward passes by up to 91% on the Emu3-Gen model without requiring any additional retraining.

Is it possible to develop an "AI Pathologist" to pass the board-certified examination of the American Board of Pathology? To achieve this goal, the first step is to create a visual question answering (VQA) dataset where the AI agent is presented with a pathology image together with a question and is asked to give the correct answer. Our work makes the first attempt to build such a dataset. Different from creating general-domain VQA datasets where the images are widely accessible and there are many crowdsourcing workers available and capable of generating question-answer pairs, developing a medical VQA dataset is much more challenging. First, due to privacy concerns, pathology images are usually not publicly available. Second, only well-trained pathologists can understand pathology images, but they barely have time to help create datasets for AI research. To address these challenges, we resort to pathology textbooks and online digital libraries. We develop a semi-automated pipeline to extract pathology images and captions from textbooks and generate question-answer pairs from captions using natural language processing. We collect 32,799 open-ended questions from 4,998 pathology images where each question is manually checked to ensure correctness. To our best knowledge, this is the first dataset for pathology VQA. Our dataset will be released publicly to promote research in medical VQA.

Virtual Try-On (VTON) is a transformative technology in e-commerce and fashion design, enabling realistic digital visualization of clothing on individuals. In this work, we propose VTON 360, a novel 3D VTON method that addresses the open challenge of achieving high-fidelity VTON that supports any-view rendering. Specifically, we leverage the equivalence between a 3D model and its rendered multi-view 2D images, and reformulate 3D VTON as an extension of 2D VTON that ensures 3D consistent results across multiple views. To achieve this, we extend 2D VTON models to include multi-view garments and clothing-agnostic human body images as input, and propose several novel techniques to enhance them, including: i) a pseudo-3D pose representation using normal maps derived from the SMPL-X 3D human model, ii) a multi-view spatial attention mechanism that models the correlations between features from different viewing angles, and iii) a multi-view CLIP embedding that enhances the garment CLIP features used in 2D VTON with camera information. Extensive experiments on large-scale real datasets and clothing images from e-commerce platforms demonstrate the effectiveness of our approach. Project page: https://scnuhealthy.github.io/VTON360.

We present LAM, an innovative Large Avatar Model for animatable Gaussian head reconstruction from a single image. Unlike previous methods that require extensive training on captured video sequences or rely on auxiliary neural networks for animation and rendering during inference, our approach generates Gaussian heads that are immediately animatable and renderable. Specifically, LAM creates an animatable Gaussian head in a single forward pass, enabling reenactment and rendering without additional networks or post-processing steps. This capability allows for seamless integration into existing rendering pipelines, ensuring real-time animation and rendering across a wide range of platforms, including mobile phones. The centerpiece of our framework is the canonical Gaussian attributes generator, which utilizes FLAME canonical points as queries. These points interact with multi-scale image features through a Transformer to accurately predict Gaussian attributes in the canonical space. The reconstructed canonical Gaussian avatar can then be animated utilizing standard linear blend skinning (LBS) with corrective blendshapes as the FLAME model did and rendered in real-time on various platforms. Our experimental results demonstrate that LAM outperforms state-of-the-art methods on existing benchmarks.

Dense contrastive representation learning (DCRL) has greatly improved the learning efficiency for image-dense prediction tasks, showing its great potential to reduce the large costs of medical image collection and dense annotation. However, the properties of medical images make unreliable correspondence discovery, bringing an open problem of large-scale false positive and negative (FP&N) pairs in DCRL. In this paper, we propose GEoMetric vIsual deNse sImilarity (GEMINI) learning which embeds the homeomorphism prior to DCRL and enables a reliable correspondence discovery for effective dense contrast. We propose a deformable homeomorphism learning (DHL) which models the homeomorphism of medical images and learns to estimate a deformable mapping to predict the pixels' correspondence under topological preservation. It effectively reduces the searching space of pairing and drives an implicit and soft learning of negative pairs via a gradient. We also propose a geometric semantic similarity (GSS) which extracts semantic information in features to measure the alignment degree for the correspondence learning. It will promote the learning efficiency and performance of deformation, constructing positive pairs reliably. We implement two practical variants on two typical representation learning tasks in our experiments. Our promising results on seven datasets which outperform the existing methods show our great superiority. We will release our code on a companion link: https://github.com/YutingHe-list/GEMINI.

Recent research shows that emotions can enhance users' cognition and influence information communication. While research on visual emotion analysis is extensive, limited work has been done on helping users generate emotionally rich image content. Existing work on emotional image generation relies on discrete emotion categories, making it challenging to capture complex and subtle emotional nuances accurately. Additionally, these methods struggle to control the specific content of generated images based on text prompts. In this work, we introduce the new task of continuous emotional image content generation (C-EICG) and present EmotiCrafter, an emotional image generation model that generates images based on text prompts and Valence-Arousal values. Specifically, we propose a novel emotion-embedding mapping network that embeds Valence-Arousal values into textual features, enabling the capture of specific emotions in alignment with intended input prompts. Additionally, we introduce a loss function to enhance emotion expression. The experimental results show that our method effectively generates images representing specific emotions with the desired content and outperforms existing techniques.

This paper presents a novel iterative deep learning framework and apply it for document enhancement and binarization. Unlike the traditional methods which predict the binary label of each pixel on the input image, we train the neural network to learn the degradations in document images and produce the uniform images of the degraded input images, which allows the network to refine the output iteratively. Two different iterative methods have been studied in this paper: recurrent refinement (RR) which uses the same trained neural network in each iteration for document enhancement and stacked refinement (SR) which uses a stack of different neural networks for iterative output refinement. Given the learned uniform and enhanced image, the binarization map can be easy to obtain by a global or local threshold. The experimental results on several public benchmark data sets show that our proposed methods provide a new clean version of the degraded image which is suitable for visualization and promising results of binarization using the global Otsu's threshold based on the enhanced images learned iteratively by the neural network.

Diffusion models have demonstrated remarkable efficacy across various image-to-image tasks. In this research, we introduce Imagine yourself, a state-of-the-art model designed for personalized image generation. Unlike conventional tuning-based personalization techniques, Imagine yourself operates as a tuning-free model, enabling all users to leverage a shared framework without individualized adjustments. Moreover, previous work met challenges balancing identity preservation, following complex prompts and preserving good visual quality, resulting in models having strong copy-paste effect of the reference images. Thus, they can hardly generate images following prompts that require significant changes to the reference image, \eg, changing facial expression, head and body poses, and the diversity of the generated images is low. To address these limitations, our proposed method introduces 1) a new synthetic paired data generation mechanism to encourage image diversity, 2) a fully parallel attention architecture with three text encoders and a fully trainable vision encoder to improve the text faithfulness, and 3) a novel coarse-to-fine multi-stage finetuning methodology that gradually pushes the boundary of visual quality. Our study demonstrates that Imagine yourself surpasses the state-of-the-art personalization model, exhibiting superior capabilities in identity preservation, visual quality, and text alignment. This model establishes a robust foundation for various personalization applications. Human evaluation results validate the model's SOTA superiority across all aspects (identity preservation, text faithfulness, and visual appeal) compared to the previous personalization models.

Bridging different modalities lies at the heart of cross-modality generation. While conventional approaches treat the text modality as a conditioning signal that gradually guides the denoising process from Gaussian noise to the target image modality, we explore a much simpler paradigm-directly evolving between text and image modalities through flow matching. This requires projecting both modalities into a shared latent space, which poses a significant challenge due to their inherently different representations: text is highly semantic and encoded as 1D tokens, whereas images are spatially redundant and represented as 2D latent embeddings. To address this, we introduce FlowTok, a minimal framework that seamlessly flows across text and images by encoding images into a compact 1D token representation. Compared to prior methods, this design reduces the latent space size by 3.3x at an image resolution of 256, eliminating the need for complex conditioning mechanisms or noise scheduling. Moreover, FlowTok naturally extends to image-to-text generation under the same formulation. With its streamlined architecture centered around compact 1D tokens, FlowTok is highly memory-efficient, requires significantly fewer training resources, and achieves much faster sampling speeds-all while delivering performance comparable to state-of-the-art models. Code will be available at https://github.com/bytedance/1d-tokenizer.

Recently, large-scale generative models have demonstrated outstanding text-to-image generation capabilities. However, generating high-fidelity personalized images with specific subjects still presents challenges, especially in cases involving multiple subjects. In this paper, we propose AnyStory, a unified approach for personalized subject generation. AnyStory not only achieves high-fidelity personalization for single subjects, but also for multiple subjects, without sacrificing subject fidelity. Specifically, AnyStory models the subject personalization problem in an "encode-then-route" manner. In the encoding step, AnyStory utilizes a universal and powerful image encoder, i.e., ReferenceNet, in conjunction with CLIP vision encoder to achieve high-fidelity encoding of subject features. In the routing step, AnyStory utilizes a decoupled instance-aware subject router to accurately perceive and predict the potential location of the corresponding subject in the latent space, and guide the injection of subject conditions. Detailed experimental results demonstrate the excellent performance of our method in retaining subject details, aligning text descriptions, and personalizing for multiple subjects. The project page is at https://aigcdesigngroup.github.io/AnyStory/ .

Image matching, which aims to identify corresponding pixel locations between images, is crucial in a wide range of scientific disciplines, aiding in image registration, fusion, and analysis. In recent years, deep learning-based image matching algorithms have dramatically outperformed humans in rapidly and accurately finding large amounts of correspondences. However, when dealing with images captured under different imaging modalities that result in significant appearance changes, the performance of these algorithms often deteriorates due to the scarcity of annotated cross-modal training data. This limitation hinders applications in various fields that rely on multiple image modalities to obtain complementary information. To address this challenge, we propose a large-scale pre-training framework that utilizes synthetic cross-modal training signals, incorporating diverse data from various sources, to train models to recognize and match fundamental structures across images. This capability is transferable to real-world, unseen cross-modality image matching tasks. Our key finding is that the matching model trained with our framework achieves remarkable generalizability across more than eight unseen cross-modality registration tasks using the same network weight, substantially outperforming existing methods, whether designed for generalization or tailored for specific tasks. This advancement significantly enhances the applicability of image matching technologies across various scientific disciplines and paves the way for new applications in multi-modality human and artificial intelligence analysis and beyond.

Object detection systems must reliably perceive objects of interest without being overly confident to ensure safe decision-making in dynamic environments. Filtering techniques based on out-of-distribution (OoD) detection are commonly added as an extra safeguard to filter hallucinations caused by overconfidence in novel objects. Nevertheless, evaluating YOLO-family detectors and their filters under existing OoD benchmarks often leads to unsatisfactory performance. This paper studies the underlying reasons for performance bottlenecks and proposes a methodology to improve performance fundamentally. Our first contribution is a calibration of all existing evaluation results: Although images in existing OoD benchmark datasets are claimed not to have objects within in-distribution (ID) classes (i.e., categories defined in the training dataset), around 13% of objects detected by the object detector are actually ID objects. Dually, the ID dataset containing OoD objects can also negatively impact the decision boundary of filters. These ultimately lead to a significantly imprecise performance estimation. Our second contribution is to consider the task of hallucination reduction as a joint pipeline of detectors and filters. By developing a methodology to carefully synthesize an OoD dataset that semantically resembles the objects to be detected, and using the crafted OoD dataset in the fine-tuning of YOLO detectors to suppress the objectness score, we achieve a 88% reduction in overall hallucination error with a combined fine-tuned detection and filtering system on the self-driving benchmark BDD-100K. Our code and dataset are available at: https://gricad-gitlab.univ-grenoble-alpes.fr/dnn-safety/m-hood.

Pan-sharpening involves reconstructing missing high-frequency information in multi-spectral images with low spatial resolution, using a higher-resolution panchromatic image as guidance. Although the inborn connection with frequency domain, existing pan-sharpening research has not almost investigated the potential solution upon frequency domain. To this end, we propose a novel Frequency Adaptive Mixture of Experts (FAME) learning framework for pan-sharpening, which consists of three key components: the Adaptive Frequency Separation Prediction Module, the Sub-Frequency Learning Expert Module, and the Expert Mixture Module. In detail, the first leverages the discrete cosine transform to perform frequency separation by predicting the frequency mask. On the basis of generated mask, the second with low-frequency MOE and high-frequency MOE takes account for enabling the effective low-frequency and high-frequency information reconstruction. Followed by, the final fusion module dynamically weights high-frequency and low-frequency MOE knowledge to adapt to remote sensing images with significant content variations. Quantitative and qualitative experiments over multiple datasets demonstrate that our method performs the best against other state-of-the-art ones and comprises a strong generalization ability for real-world scenes. Code will be made publicly at https://github.com/alexhe101/FAME-Net.

Accurate 3D cardiac reconstruction from cine magnetic resonance imaging (cMRI) is crucial for improved cardiovascular disease diagnosis and understanding of the heart's motion. However, current cardiac MRI-based reconstruction technology used in clinical settings is 2D with limited through-plane resolution, resulting in low-quality reconstructed cardiac volumes. To better reconstruct 3D cardiac volumes from sparse 2D image stacks, we propose a morphology-guided diffusion model for 3D cardiac volume reconstruction, DMCVR, that synthesizes high-resolution 2D images and corresponding 3D reconstructed volumes. Our method outperforms previous approaches by conditioning the cardiac morphology on the generative model, eliminating the time-consuming iterative optimization process of the latent code, and improving generation quality. The learned latent spaces provide global semantics, local cardiac morphology and details of each 2D cMRI slice with highly interpretable value to reconstruct 3D cardiac shape. Our experiments show that DMCVR is highly effective in several aspects, such as 2D generation and 3D reconstruction performance. With DMCVR, we can produce high-resolution 3D cardiac MRI reconstructions, surpassing current techniques. Our proposed framework has great potential for improving the accuracy of cardiac disease diagnosis and treatment planning. Code can be accessed at https://github.com/hexiaoxiao-cs/DMCVR.

Today's image generation systems are capable of producing realistic and high-quality images. However, user prompts often contain ambiguities, making it difficult for these systems to interpret users' actual intentions. Consequently, many users must modify their prompts several times to ensure the generated images meet their expectations. While some methods focus on enhancing prompts to make the generated images fit user needs, the model is still hard to understand users' real needs, especially for non-expert users. In this research, we aim to enhance the visual parameter-tuning process, making the model user-friendly for individuals without specialized knowledge and better understand user needs. We propose a human-machine co-adaption strategy using mutual information between the user's prompts and the pictures under modification as the optimizing target to make the system better adapt to user needs. We find that an improved model can reduce the necessity for multiple rounds of adjustments. We also collect multi-round dialogue datasets with prompts and images pairs and user intent. Various experiments demonstrate the effectiveness of the proposed method in our proposed dataset. Our annotation tools and several examples of our dataset are available at https://zenodo.org/records/14876029 for easier review. We will make open source our full dataset and code.

Concept Bottleneck Models (CBMs) offer inherent interpretability by initially translating images into human-comprehensible concepts, followed by a linear combination of these concepts for classification. However, the annotation of concepts for visual recognition tasks requires extensive expert knowledge and labor, constraining the broad adoption of CBMs. Recent approaches have leveraged the knowledge of large language models to construct concept bottlenecks, with multimodal models like CLIP subsequently mapping image features into the concept feature space for classification. Despite this, the concepts produced by language models can be verbose and may introduce non-visual attributes, which hurts accuracy and interpretability. In this study, we investigate to avoid these issues by constructing CBMs directly from multimodal models. To this end, we adopt common words as base concept vocabulary and leverage auxiliary unlabeled images to construct a Vision-to-Concept (V2C) tokenizer that can explicitly quantize images into their most relevant visual concepts, thus creating a vision-oriented concept bottleneck tightly coupled with the multimodal model. This leads to our V2C-CBM which is training efficient and interpretable with high accuracy. Our V2C-CBM has matched or outperformed LLM-supervised CBMs on various visual classification benchmarks, validating the efficacy of our approach.

Training-free diffusion models have achieved remarkable progress in generating multi-subject consistent images within open-domain scenarios. The key idea of these methods is to incorporate reference subject information within the attention layer. However, existing methods still obtain suboptimal performance when handling numerous subjects. This paper reveals the two primary issues contributing to this deficiency. Firstly, there is undesired interference among different subjects within the target image. Secondly, tokens tend to reference nearby tokens, which reduces the effectiveness of the attention mechanism when there is a significant positional difference between subjects in reference and target images. To address these challenges, we propose a training-free diffusion model with Isolation and Reposition Attention, named IR-Diffusion. Specifically, Isolation Attention ensures that multiple subjects in the target image do not reference each other, effectively eliminating the subject fusion. On the other hand, Reposition Attention involves scaling and repositioning subjects in both reference and target images to the same position within the images. This ensures that subjects in the target image can better reference those in the reference image, thereby maintaining better consistency. Extensive experiments demonstrate that the proposed methods significantly enhance multi-subject consistency, outperforming all existing methods in open-domain scenarios.

Text logo design heavily relies on the creativity and expertise of professional designers, in which arranging element layouts is one of the most important procedures. However, few attention has been paid to this specific task which needs to take precise textural details and user constraints into consideration, but only on the broader tasks such as document/poster layout generation. In this paper, we propose a VLM-based framework that generates content-aware text logo layouts by integrating multi-modal inputs with user constraints, supporting a more flexible and stable layout design in real-world applications. We introduce two model techniques to reduce the computation for processing multiple glyph images simultaneously, while does not face performance degradation. To support instruction-tuning of out model, we construct two extensive text logo datasets, which are 5x more larger than the existing public dataset. Except for the geometric annotations (e.g. text masks and character recognition), we also compliment with comprehensive layout descriptions in natural language format, for more effective training to have reasoning ability when dealing with complex layouts and custom user constraints. Experimental studies demonstrate the effectiveness of our proposed model and datasets, when comparing with previous methods in various benchmarks to evaluate geometric aesthetics and human preferences. The code and datasets will be publicly available.

Large-scale vision foundation models such as Segment Anything (SAM) demonstrate impressive performance in zero-shot image segmentation at multiple levels of granularity. However, these zero-shot predictions are rarely 3D-consistent. As the camera viewpoint changes in a scene, so do the segmentation predictions, as well as the characterizations of "coarse" or "fine" granularity. In this work, we address the challenging task of lifting multi-granular and view-inconsistent image segmentations into a hierarchical and 3D-consistent representation. We learn a novel feature field within a Neural Radiance Field (NeRF) representing a 3D scene, whose segmentation structure can be revealed at different scales by simply using different thresholds on feature distance. Our key idea is to learn an ultrametric feature space, which unlike a Euclidean space, exhibits transitivity in distance-based grouping, naturally leading to a hierarchical clustering. Put together, our method takes view-inconsistent multi-granularity 2D segmentations as input and produces a hierarchy of 3D-consistent segmentations as output. We evaluate our method and several baselines on synthetic datasets with multi-view images and multi-granular segmentation, showcasing improved accuracy and viewpoint-consistency. We additionally provide qualitative examples of our model's 3D hierarchical segmentations in real world scenes. The code and dataset are available at https://github.com/hardyho/ultrametric_feature_fields

Skin disease is one of the most common types of human diseases, which may happen to everyone regardless of age, gender or race. Due to the high visual diversity, human diagnosis highly relies on personal experience; and there is a serious shortage of experienced dermatologists in many countries. To alleviate this problem, computer-aided diagnosis with state-of-the-art (SOTA) machine learning techniques would be a promising solution. In this paper, we aim at understanding the performance of convolutional neural network (CNN) based approaches. We first build two versions of skin disease datasets from Internet images: (a) Skin-10, which contains 10 common classes of skin disease with a total of 10,218 images; (b) Skin-100, which is a larger dataset that consists of 19,807 images of 100 skin disease classes. Based on these datasets, we benchmark several SOTA CNN models and show that the accuracy of skin-100 is much lower than the accuracy of skin-10. We then implement an ensemble method based on several CNN models and achieve the best accuracy of 79.01\% for Skin-10 and 53.54\% for Skin-100. We also present an object detection based approach by introducing bounding boxes into the Skin-10 dataset. Our results show that object detection can help improve the accuracy of some skin disease classes.