Daily Papers

Traffic forecasting is a fundamental task in transportation research, however the scope of current research has mainly focused on a single data modality of loop detectors. Recently, the advances in Artificial Intelligence and drone technologies have made possible novel solutions for efficient, accurate and flexible aerial observations of urban traffic. As a promising traffic monitoring approach, drone-captured data can create an accurate multi-sensor mobility observatory for large-scale urban networks, when combined with existing infrastructure. Therefore, this paper investigates the problem of multi-source traffic speed prediction, simultaneously using drone and loop detector data. A simple yet effective graph-based model HiMSNet is proposed to integrate multiple data modalities and learn spatio-temporal correlations. Detailed analysis shows that predicting accurate segment-level speed is more challenging than the regional speed, especially under high-demand scenarios with heavier congestions and varying traffic dynamics. Utilizing both drone and loop detector data, the prediction accuracy can be improved compared to single-modality cases, when the sensors have lower coverages and are subject to noise. Our simulation study based on vehicle trajectories in a real urban road network has highlighted the added value of integrating drones in traffic forecasting and monitoring.

Human perception of the world is shaped by a multitude of viewpoints and modalities. While many existing datasets focus on scene understanding from a certain perspective (e.g. egocentric or third-person views), our dataset offers a panoptic perspective (i.e. multiple viewpoints with multiple data modalities). Specifically, we encapsulate third-person panoramic and front views, as well as egocentric monocular/binocular views with rich modalities including video, multi-channel audio, directional binaural delay, location data and textual scene descriptions within each scene captured, presenting comprehensive observation of the world. Figure 1 offers a glimpse of all 28 scene categories of our 360+x dataset. To the best of our knowledge, this is the first database that covers multiple viewpoints with multiple data modalities to mimic how daily information is accessed in the real world. Through our benchmark analysis, we presented 5 different scene understanding tasks on the proposed 360+x dataset to evaluate the impact and benefit of each data modality and perspective in panoptic scene understanding. We hope this unique dataset could broaden the scope of comprehensive scene understanding and encourage the community to approach these problems from more diverse perspectives.

Multimodal learning combines multiple data modalities, broadening the types and complexity of data our models can utilize: for example, from plain text to image-caption pairs. Most multimodal learning algorithms focus on modeling simple one-to-one pairs of data from two modalities, such as image-caption pairs, or audio-text pairs. However, in most real-world settings, entities of different modalities interact with each other in more complex and multifaceted ways, going beyond one-to-one mappings. We propose to represent these complex relationships as graphs, allowing us to capture data with any number of modalities, and with complex relationships between modalities that can flexibly vary from one sample to another. Toward this goal, we propose Multimodal Graph Learning (MMGL), a general and systematic framework for capturing information from multiple multimodal neighbors with relational structures among them. In particular, we focus on MMGL for generative tasks, building upon pretrained Language Models (LMs), aiming to augment their text generation with multimodal neighbor contexts. We study three research questions raised by MMGL: (1) how can we infuse multiple neighbor information into the pretrained LMs, while avoiding scalability issues? (2) how can we infuse the graph structure information among multimodal neighbors into the LMs? and (3) how can we finetune the pretrained LMs to learn from the neighbor context in a parameter-efficient manner? We conduct extensive experiments to answer these three questions on MMGL and analyze the empirical results to pave the way for future MMGL research.

Clinical diagnosis of the eye is performed over multifarious data modalities including scalar clinical labels, vectorized biomarkers, two-dimensional fundus images, and three-dimensional Optical Coherence Tomography (OCT) scans. Clinical practitioners use all available data modalities for diagnosing and treating eye diseases like Diabetic Retinopathy (DR) or Diabetic Macular Edema (DME). Enabling usage of machine learning algorithms within the ophthalmic medical domain requires research into the relationships and interactions between all relevant data over a treatment period. Existing datasets are limited in that they neither provide data nor consider the explicit relationship modeling between the data modalities. In this paper, we introduce the Ophthalmic Labels for Investigating Visual Eye Semantics (OLIVES) dataset that addresses the above limitation. This is the first OCT and near-IR fundus dataset that includes clinical labels, biomarker labels, disease labels, and time-series patient treatment information from associated clinical trials. The dataset consists of 1268 near-IR fundus images each with at least 49 OCT scans, and 16 biomarkers, along with 4 clinical labels and a disease diagnosis of DR or DME. In total, there are 96 eyes' data averaged over a period of at least two years with each eye treated for an average of 66 weeks and 7 injections. We benchmark the utility of OLIVES dataset for ophthalmic data as well as provide benchmarks and concrete research directions for core and emerging machine learning paradigms within medical image analysis.

Telecom networks are becoming increasingly complex, with diversified deployment scenarios, multi-standards, and multi-vendor support. The intricate nature of the telecom network ecosystem presents challenges to effectively manage, operate, and optimize networks. To address these hurdles, Artificial Intelligence (AI) has been widely adopted to solve different tasks in telecom networks. However, these conventional AI models are often designed for specific tasks, rely on extensive and costly-to-collect labeled data that require specialized telecom expertise for development and maintenance. The AI models usually fail to generalize and support diverse deployment scenarios and applications. In contrast, Foundation Models (FMs) show effective generalization capabilities in various domains in language, vision, and decision-making tasks. FMs can be trained on multiple data modalities generated from the telecom ecosystem and leverage specialized domain knowledge. Moreover, FMs can be fine-tuned to solve numerous specialized tasks with minimal task-specific labeled data and, in some instances, are able to leverage context to solve previously unseen problems. At the dawn of 6G, this paper investigates the potential opportunities of using FMs to shape the future of telecom technologies and standards. In particular, the paper outlines a conceptual process for developing Telecom FMs (TFMs) and discusses emerging opportunities for orchestrating specialized TFMs for network configuration, operation, and maintenance. Finally, the paper discusses the limitations and challenges of developing and deploying TFMs.

Multimodal Large Language Models (MLLMs) have demonstrated remarkable capabilities in processing and generating content across multiple data modalities, including text, images, audio, and video. However, a significant drawback of MLLMs is their reliance on static training data, leading to outdated information and limited contextual awareness. This static nature hampers their ability to provide accurate, up-to-date responses, particularly in dynamic or rapidly evolving contexts. Integrating Multimodal Retrieval-augmented Generation (Multimodal RAG) offers a promising solution, but the system would inevitably encounter the multi-granularity noisy correspondence (MNC) problem, which involves two types of noise: coarse-grained (query-caption) and fine-grained (query-image). This noise hinders accurate retrieval and generation. In this work, we propose RagLLaVA, a novel framework with knowledge-enhanced reranking and noise-injected training, to address these limitations. We instruction-tune the MLLM with a simple yet effective instruction template to induce its ranking ability and serve it as a reranker to precisely filter the top-k retrieved images. For generation, we inject visual noise during training at the data and token levels to enhance the generator's robustness. Extensive experiments are conducted on the subsets of two datasets that require retrieving and reasoning over images to answer a given query. Our results demonstrate the superiority of RagLLaVA in retrieving accurately and generating robustly. Code and models are available at https://github.com/IDEA-FinAI/RagLLaVA.

Self-supervised learning excels in learning representations from large amounts of unlabeled data, demonstrating success across multiple data modalities. Yet, extending self-supervised learning to new modalities is non-trivial because the specifics of existing methods are tailored to each domain, such as domain-specific augmentations which reflect the invariances in the target task. While masked modeling is promising as a domain-agnostic framework for self-supervised learning because it does not rely on input augmentations, its mask sampling procedure remains domain-specific. We present Self-guided Masked Autoencoders (SMA), a fully domain-agnostic masked modeling method. SMA trains an attention based model using a masked modeling objective, by learning masks to sample without any domain-specific assumptions. We evaluate SMA on three self-supervised learning benchmarks in protein biology, chemical property prediction, and particle physics. We find SMA is capable of learning representations without domain-specific knowledge and achieves state-of-the-art performance on these three benchmarks.

Multimodal Large Language Models (MLLMs) have become increasingly important due to their state-of-the-art performance and ability to integrate multiple data modalities, such as text, images, and audio, to perform complex tasks with high accuracy. This paper presents a comprehensive survey on personalized multimodal large language models, focusing on their architecture, training methods, and applications. We propose an intuitive taxonomy for categorizing the techniques used to personalize MLLMs to individual users, and discuss the techniques accordingly. Furthermore, we discuss how such techniques can be combined or adapted when appropriate, highlighting their advantages and underlying rationale. We also provide a succinct summary of personalization tasks investigated in existing research, along with the evaluation metrics commonly used. Additionally, we summarize the datasets that are useful for benchmarking personalized MLLMs. Finally, we outline critical open challenges. This survey aims to serve as a valuable resource for researchers and practitioners seeking to understand and advance the development of personalized multimodal large language models.

Current benchmarks for evaluating Vision Language Models (VLMs) often fall short in thoroughly assessing model abilities to understand and process complex visual and textual content. They typically focus on simple tasks that do not require deep reasoning or the integration of multiple data modalities to solve an original problem. To address this gap, we introduce the PARROT-360V Benchmark, a novel and comprehensive benchmark featuring 2487 challenging visual puzzles designed to test VLMs on complex visual reasoning tasks. We evaluated leading models: GPT-4o, Claude-3.5-Sonnet, and Gemini-1.5-Pro, using PARROT-360V to assess their capabilities in combining visual clues with language skills to solve tasks in a manner akin to human problem-solving. Our findings reveal a notable performance gap: state-of-the-art models scored between 28 to 56 percentage on our benchmark, significantly lower than their performance on popular benchmarks. This underscores the limitations of current VLMs in handling complex, multi-step reasoning tasks and highlights the need for more robust evaluation frameworks to advance the field.

Lack of rigorous reproducibility and validation are major hurdles for scientific development across many fields. Materials science in particular encompasses a variety of experimental and theoretical approaches that require careful benchmarking. Leaderboard efforts have been developed previously to mitigate these issues. However, a comprehensive comparison and benchmarking on an integrated platform with multiple data modalities with both perfect and defect materials data is still lacking. This work introduces JARVIS-Leaderboard, an open-source and community-driven platform that facilitates benchmarking and enhances reproducibility. The platform allows users to set up benchmarks with custom tasks and enables contributions in the form of dataset, code, and meta-data submissions. We cover the following materials design categories: Artificial Intelligence (AI), Electronic Structure (ES), Force-fields (FF), Quantum Computation (QC) and Experiments (EXP). For AI, we cover several types of input data, including atomic structures, atomistic images, spectra, and text. For ES, we consider multiple ES approaches, software packages, pseudopotentials, materials, and properties, comparing results to experiment. For FF, we compare multiple approaches for material property predictions. For QC, we benchmark Hamiltonian simulations using various quantum algorithms and circuits. Finally, for experiments, we use the inter-laboratory approach to establish benchmarks. There are 1281 contributions to 274 benchmarks using 152 methods with more than 8 million data-points, and the leaderboard is continuously expanding. The JARVIS-Leaderboard is available at the website: https://pages.nist.gov/jarvis_leaderboard

The approval success rate of drug candidates is very low with the majority of failure due to safety and efficacy. Increasingly available high dimensional information on targets, drug molecules and indications provides an opportunity for ML methods to integrate multiple data modalities and better predict clinically promising drug targets. Notably, drug targets with human genetics evidence are shown to have better odds to succeed. However, a recent tensor factorization-based approach found that additional information on targets and indications might not necessarily improve the predictive accuracy. Here we revisit this approach by integrating different types of human genetics evidence collated from publicly available sources to support each target-indication pair. We use Bayesian tensor factorization to show that models incorporating all available human genetics evidence (rare disease, gene burden, common disease) modestly improves the clinical outcome prediction over models using single line of genetics evidence. We provide additional insight into the relative predictive power of different types of human genetics evidence for predicting the success of clinical outcomes.

Object pose estimation is a fundamental computer vision problem with broad applications in augmented reality and robotics. Over the past decade, deep learning models, due to their superior accuracy and robustness, have increasingly supplanted conventional algorithms reliant on engineered point pair features. Nevertheless, several challenges persist in contemporary methods, including their dependency on labeled training data, model compactness, robustness under challenging conditions, and their ability to generalize to novel unseen objects. A recent survey discussing the progress made on different aspects of this area, outstanding challenges, and promising future directions, is missing. To fill this gap, we discuss the recent advances in deep learning-based object pose estimation, covering all three formulations of the problem, i.e., instance-level, category-level, and unseen object pose estimation. Our survey also covers multiple input data modalities, degrees-of-freedom of output poses, object properties, and downstream tasks, providing the readers with a holistic understanding of this field. Additionally, it discusses training paradigms of different domains, inference modes, application areas, evaluation metrics, and benchmark datasets, as well as reports the performance of current state-of-the-art methods on these benchmarks, thereby facilitating the readers in selecting the most suitable method for their application. Finally, the survey identifies key challenges, reviews the prevailing trends along with their pros and cons, and identifies promising directions for future research. We also keep tracing the latest works at https://github.com/CNJianLiu/Awesome-Object-Pose-Estimation.

The development of foundation models has revolutionized our ability to interpret the Earth's surface using satellite observational data. Traditional models have been siloed, tailored to specific sensors or data types like optical, radar, and hyperspectral, each with its own unique characteristics. This specialization hinders the potential for a holistic analysis that could benefit from the combined strengths of these diverse data sources. Our novel approach introduces the Dynamic One-For-All (DOFA) model, leveraging the concept of neural plasticity in brain science to integrate various data modalities into a single framework adaptively. This dynamic hypernetwork, adjusting to different wavelengths, enables a single versatile Transformer jointly trained on data from five sensors to excel across 12 distinct Earth observation tasks, including sensors never seen during pretraining. DOFA's innovative design offers a promising leap towards more accurate, efficient, and unified Earth observation analysis, showcasing remarkable adaptability and performance in harnessing the potential of multimodal Earth observation data.

Large Language Models (LLMs) have shown remarkable success, and their multimodal expansions (MLLMs) further unlock capabilities spanning images, videos, and other modalities beyond text. However, despite this shift, prompt optimization approaches, designed to reduce the burden of manual prompt crafting while maximizing performance, remain confined to text, ultimately limiting the full potential of MLLMs. Motivated by this gap, we introduce the new problem of multimodal prompt optimization, which expands the prior definition of prompt optimization to the multimodal space defined by the pairs of textual and non-textual prompts. To tackle this problem, we then propose the Multimodal Prompt Optimizer (MPO), a unified framework that not only performs the joint optimization of multimodal prompts through alignment-preserving updates but also guides the selection process of candidate prompts by leveraging earlier evaluations as priors in a Bayesian-based selection strategy. Through extensive experiments across diverse modalities that go beyond text, such as images, videos, and even molecules, we demonstrate that MPO outperforms leading text-only optimization methods, establishing multimodal prompt optimization as a crucial step to realizing the potential of MLLMs.

Robust and accurate segmentation of scenes has become one core functionality in various visual recognition and navigation tasks. This has inspired the recent development of Segment Anything Model (SAM), a foundation model for general mask segmentation. However, SAM is largely tailored for single-modal RGB images, limiting its applicability to multi-modal data captured with widely-adopted sensor suites, such as LiDAR plus RGB, depth plus RGB, thermal plus RGB, etc. We develop MM-SAM, an extension and expansion of SAM that supports cross-modal and multi-modal processing for robust and enhanced segmentation with different sensor suites. MM-SAM features two key designs, namely, unsupervised cross-modal transfer and weakly-supervised multi-modal fusion, enabling label-efficient and parameter-efficient adaptation toward various sensor modalities. It addresses three main challenges: 1) adaptation toward diverse non-RGB sensors for single-modal processing, 2) synergistic processing of multi-modal data via sensor fusion, and 3) mask-free training for different downstream tasks. Extensive experiments show that MM-SAM consistently outperforms SAM by large margins, demonstrating its effectiveness and robustness across various sensors and data modalities.

We present a self-supervised framework that learns population-level codes for arbitrary ensembles of neural recordings at scale. We address two key challenges in scaling models with neural time-series data: sparse and variable electrode distribution across subjects and datasets. The Population Transformer (PopT) stacks on top of pretrained representations and enhances downstream decoding by enabling learned aggregation of multiple spatially-sparse data channels. The pretrained PopT lowers the amount of data required for downstream decoding experiments, while increasing accuracy, even on held-out subjects and tasks. Compared to end-to-end methods, this approach is computationally lightweight and more interpretable, while still retaining competitive performance. We further show how our framework is generalizable to multiple time-series embeddings and neural data modalities. Beyond decoding, we interpret the pretrained PopT and fine-tuned models to show how they can be used to extract neuroscience insights from massive amounts of data. We release our code as well as a pretrained PopT to enable off-the-shelf improvements in multi-channel intracranial data decoding and interpretability.

Transformers, composed of multiple self-attention layers, hold strong promises toward a generic learning primitive applicable to different data modalities, including the recent breakthroughs in computer vision achieving state-of-the-art (SOTA) standard accuracy. What remains largely unexplored is their robustness evaluation and attribution. In this work, we study the robustness of the Vision Transformer (ViT) against common corruptions and perturbations, distribution shifts, and natural adversarial examples. We use six different diverse ImageNet datasets concerning robust classification to conduct a comprehensive performance comparison of ViT models and SOTA convolutional neural networks (CNNs), Big-Transfer. Through a series of six systematically designed experiments, we then present analyses that provide both quantitative and qualitative indications to explain why ViTs are indeed more robust learners. For example, with fewer parameters and similar dataset and pre-training combinations, ViT gives a top-1 accuracy of 28.10% on ImageNet-A which is 4.3x higher than a comparable variant of BiT. Our analyses on image masking, Fourier spectrum sensitivity, and spread on discrete cosine energy spectrum reveal intriguing properties of ViT attributing to improved robustness. Code for reproducing our experiments is available at https://git.io/J3VO0.

Virtual cell modeling represents an emerging frontier at the intersection of artificial intelligence and biology, aiming to predict quantities such as responses to diverse perturbations quantitatively. However, autonomously building computational models for virtual cells is challenging due to the complexity of biological systems, the heterogeneity of data modalities, and the need for domain-specific expertise across multiple disciplines. Here, we introduce CellForge, an agentic system that leverages a multi-agent framework that transforms presented biological datasets and research objectives directly into optimized computational models for virtual cells. More specifically, given only raw single-cell multi-omics data and task descriptions as input, CellForge outputs both an optimized model architecture and executable code for training virtual cell models and inference. The framework integrates three core modules: Task Analysis for presented dataset characterization and relevant literature retrieval, Method Design, where specialized agents collaboratively develop optimized modeling strategies, and Experiment Execution for automated generation of code. The agents in the Design module are separated into experts with differing perspectives and a central moderator, and have to collaboratively exchange solutions until they achieve a reasonable consensus. We demonstrate CellForge's capabilities in single-cell perturbation prediction, using six diverse datasets that encompass gene knockouts, drug treatments, and cytokine stimulations across multiple modalities. CellForge consistently outperforms task-specific state-of-the-art methods. Overall, CellForge demonstrates how iterative interaction between LLM agents with differing perspectives provides better solutions than directly addressing a modeling challenge. Our code is publicly available at https://github.com/gersteinlab/CellForge.

Image-text multimodal representation learning aligns data across modalities and enables important medical applications, e.g., image classification, visual grounding, and cross-modal retrieval. In this work, we establish a connection between multimodal representation learning and multiple instance learning. Based on this connection, we propose a generic framework for constructing permutation-invariant score functions with many existing multimodal representation learning approaches as special cases. Furthermore, we use the framework to derive a novel contrastive learning approach and demonstrate that our method achieves state-of-the-art results in several downstream tasks.

Machine learning systems are often deployed in domains that entail data from multiple modalities, for example, phenotypic and genotypic characteristics describe patients in healthcare. Previous works have developed multimodal variational autoencoders (VAEs) that generate several modalities. We consider subjective data, where single datapoints from one modality (such as class labels) describe multiple datapoints from another modality (such as images). We theoretically and empirically demonstrate that multimodal VAEs with a mixture of experts posterior can struggle to capture variability in such surjective data.

With the rapid development of AI-generated content, the future internet may be inundated with synthetic data, making the discrimination of authentic and credible multimodal data increasingly challenging. Synthetic data detection has thus garnered widespread attention, and the performance of large multimodal models (LMMs) in this task has attracted significant interest. LMMs can provide natural language explanations for their authenticity judgments, enhancing the explainability of synthetic content detection. Simultaneously, the task of distinguishing between real and synthetic data effectively tests the perception, knowledge, and reasoning capabilities of LMMs. In response, we introduce LOKI, a novel benchmark designed to evaluate the ability of LMMs to detect synthetic data across multiple modalities. LOKI encompasses video, image, 3D, text, and audio modalities, comprising 18K carefully curated questions across 26 subcategories with clear difficulty levels. The benchmark includes coarse-grained judgment and multiple-choice questions, as well as fine-grained anomaly selection and explanation tasks, allowing for a comprehensive analysis of LMMs. We evaluated 22 open-source LMMs and 6 closed-source models on LOKI, highlighting their potential as synthetic data detectors and also revealing some limitations in the development of LMM capabilities. More information about LOKI can be found at https://opendatalab.github.io/LOKI/

Multimodal large language models (MLLMs) recently showed strong capacity in integrating data among multiple modalities, empowered by a generalizable attention architecture. Advanced methods predominantly focus on language-centric tuning while less exploring multimodal tokens mixed through attention, posing challenges in high-level tasks that require fine-grained cognition and emotion understanding. In this work, we identify the attention deficit disorder problem in multimodal learning, caused by inconsistent cross-modal attention and layer-by-layer decayed attention activation. To address this, we propose a novel attention mechanism, termed MOdular Duplex Attention (MODA), simultaneously conducting the inner-modal refinement and inter-modal interaction. MODA employs a correct-after-align strategy to effectively decouple modality alignment from cross-layer token mixing. In the alignment phase, tokens are mapped to duplex modality spaces based on the basis vectors, enabling the interaction between visual and language modality. Further, the correctness of attention scores is ensured through adaptive masked attention, which enhances the model's flexibility by allowing customizable masking patterns for different modalities. Extensive experiments on 21 benchmark datasets verify the effectiveness of MODA in perception, cognition, and emotion tasks. Source code and demo are available in https://zzcheng.top/MODA.

Pose-based action recognition is predominantly tackled by approaches which treat the input skeleton in a monolithic fashion, i.e. joints in the pose tree are processed as a whole. However, such approaches ignore the fact that action categories are often characterized by localized action dynamics involving only small subsets of part joint groups involving hands (e.g. `Thumbs up') or legs (e.g. `Kicking'). Although part-grouping based approaches exist, each part group is not considered within the global pose frame, causing such methods to fall short. Further, conventional approaches employ independent modality streams (e.g. joint, bone, joint velocity, bone velocity) and train their network multiple times on these streams, which massively increases the number of training parameters. To address these issues, we introduce PSUMNet, a novel approach for scalable and efficient pose-based action recognition. At the representation level, we propose a global frame based part stream approach as opposed to conventional modality based streams. Within each part stream, the associated data from multiple modalities is unified and consumed by the processing pipeline. Experimentally, PSUMNet achieves state of the art performance on the widely used NTURGB+D 60/120 dataset and dense joint skeleton dataset NTU 60-X/120-X. PSUMNet is highly efficient and outperforms competing methods which use 100%-400% more parameters. PSUMNet also generalizes to the SHREC hand gesture dataset with competitive performance. Overall, PSUMNet's scalability, performance and efficiency makes it an attractive choice for action recognition and for deployment on compute-restricted embedded and edge devices. Code and pretrained models can be accessed at https://github.com/skelemoa/psumnet

Existing large pre-trained models typically map text input to text output in an end-to-end manner, such as ChatGPT, or map a segment of text input to a hierarchy of action decisions, such as OpenVLA. However, humans can simultaneously generate text and actions when receiving specific input signals. For example, a driver can make precise driving decisions while conversing with a friend in the passenger seat. Motivated by this observation, we consider the following question in this work: is it possible to construct a pre-trained model that can provide both language interaction and precise decision-making capabilities in dynamic open scenarios. We provide a definitive answer to this question by developing a new model architecture termed Visual Language Action model for Chatting and Decision Making (VLA4CD), and further demonstrating its performance in challenging autonomous driving tasks. Specifically, we leverage LoRA to fine-tune a pre-trained LLM with data of multiple modalities covering language, visual, and action. Unlike the existing LoRA operations used for LLM fine-tuning, we have designed new computational modules and training cost functions for VLA4CD. These designs enable VLA4CD to provide continuous-valued action decisions while outputting text responses. In contrast, existing LLMs can only output text responses, and current VLA models can only output action decisions. Moreover, these VLA models handle action data by discretizing and then tokenizing the discretized actions, a method unsuitable for complex decision-making tasks involving high-dimensional continuous-valued action vectors, such as autonomous driving. The experimental results on CARLA validate that: (1) our proposed model construction method is effective; (2) compared to the SOTA VLA model, VLA4CD can provide more accurate real-time decision-making while retaining the text interaction capability inherent to LLMs.

Depression is a serious mental health illness that significantly affects an individual's well-being and quality of life, making early detection crucial for adequate care and treatment. Detecting depression is often difficult, as it is based primarily on subjective evaluations during clinical interviews. Hence, the early diagnosis of depression, thanks to the content of social networks, has become a prominent research area. The extensive and diverse nature of user-generated information poses a significant challenge, limiting the accurate extraction of relevant temporal information and the effective fusion of data across multiple modalities. This paper introduces MMFformer, a multimodal depression detection network designed to retrieve depressive spatio-temporal high-level patterns from multimodal social media information. The transformer network with residual connections captures spatial features from videos, and a transformer encoder is exploited to design important temporal dynamics in audio. Moreover, the fusion architecture fused the extracted features through late and intermediate fusion strategies to find out the most relevant intermodal correlations among them. Finally, the proposed network is assessed on two large-scale depression detection datasets, and the results clearly reveal that it surpasses existing state-of-the-art approaches, improving the F1-Score by 13.92% for D-Vlog dataset and 7.74% for LMVD dataset. The code is made available publicly at https://github.com/rezwanh001/Large-Scale-Multimodal-Depression-Detection.

Multimodal learning seeks to utilize data from multiple sources to improve the overall performance of downstream tasks. It is desirable for redundancies in the data to make multimodal systems robust to missing or corrupted observations in some correlated modalities. However, we observe that the performance of several existing multimodal networks significantly deteriorates if one or multiple modalities are absent at test time. To enable robustness to missing modalities, we propose a simple and parameter-efficient adaptation procedure for pretrained multimodal networks. In particular, we exploit modulation of intermediate features to compensate for the missing modalities. We demonstrate that such adaptation can partially bridge performance drop due to missing modalities and outperform independent, dedicated networks trained for the available modality combinations in some cases. The proposed adaptation requires extremely small number of parameters (e.g., fewer than 1% of the total parameters) and applicable to a wide range of modality combinations and tasks. We conduct a series of experiments to highlight the missing modality robustness of our proposed method on five different multimodal tasks across seven datasets. Our proposed method demonstrates versatility across various tasks and datasets, and outperforms existing methods for robust multimodal learning with missing modalities.

The computer vision domain has greatly benefited from an abundance of data across many modalities to improve on various visual tasks. Recently, there has been a lot of focus on self-supervised pre-training methods through Masked Autoencoders (MAE) he2022masked,bachmann2022multimae, usually used as a first step before optimizing for a downstream task, such as classification or regression. This is very useful as it doesn't require any manually labeled data. In this work, we introduce Probabilistic Hyper-Graphs using Masked Autoencoders (PHG-MAE): a novel model that unifies the classical work on neural graphs leordeanu2021semi with the modern approach of masked autoencoders under a common theoretical framework. Through random masking of entire modalities, not just patches, the model samples from the distribution of hyper-edges on each forward pass. Additionally, the model adapts the standard MAE algorithm by combining pre-training and fine-tuning into a single training loop. Moreover, our approach enables the creation of inference-time ensembles which, through aggregation, boost the final prediction performance and consistency. Lastly, we show that we can apply knowledge distillation on top of the ensembles with little loss in performance, even with models that have fewer than 1M parameters. While our work mostly focuses on outdoor UAV scenes that contain multiple world interpretations and modalities, the same steps can be followed in other similar domains, such as autonomous driving or indoor robotics. In order to streamline the process of integrating external pre-trained experts for computer vision multi-modal multi-task learning (MTL) scenarios, we developed a data-pipeline software. Using this tool, we have created and released a fully-automated extension of the Dronescapes dataset. All the technical details, code and reproduction steps are publicly released.

Full-stack autonomous driving perception modules usually consist of data-driven models based on multiple sensor modalities. However, these models might be biased to the sensor setup used for data acquisition. This bias can seriously impair the perception models' transferability to new sensor setups, which continuously occur due to the market's competitive nature. We envision sensor data abstraction as an interface between sensor data and machine learning applications for highly automated vehicles (HAD). For this purpose, we review the primary sensor modalities, camera, lidar, and radar, published in autonomous-driving related datasets, examine single sensor abstraction and abstraction of sensor setups, and identify critical paths towards an abstraction of sensor data from multiple perception configurations.

Misinformation is becoming increasingly prevalent on social media and in news articles. It has become so widespread that we require algorithmic assistance utilising machine learning to detect such content. Training these machine learning models require datasets of sufficient scale, diversity and quality. However, datasets in the field of automatic misinformation detection are predominantly monolingual, include a limited amount of modalities and are not of sufficient scale and quality. Addressing this, we develop a data collection and linking system (MuMiN-trawl), to build a public misinformation graph dataset (MuMiN), containing rich social media data (tweets, replies, users, images, articles, hashtags) spanning 21 million tweets belonging to 26 thousand Twitter threads, each of which have been semantically linked to 13 thousand fact-checked claims across dozens of topics, events and domains, in 41 different languages, spanning more than a decade. The dataset is made available as a heterogeneous graph via a Python package (mumin). We provide baseline results for two node classification tasks related to the veracity of a claim involving social media, and demonstrate that these are challenging tasks, with the highest macro-average F1-score being 62.55% and 61.45% for the two tasks, respectively. The MuMiN ecosystem is available at https://mumin-dataset.github.io/, including the data, documentation, tutorials and leaderboards.

To effectively exploit the potential of large-scale models, various pre-training strategies supported by massive data from different sources are proposed, including supervised pre-training, weakly-supervised pre-training, and self-supervised pre-training. It has been proved that combining multiple pre-training strategies and data from various modalities/sources can greatly boost the training of large-scale models. However, current works adopt a multi-stage pre-training system, where the complex pipeline may increase the uncertainty and instability of the pre-training. It is thus desirable that these strategies can be integrated in a single-stage manner. In this paper, we first propose a general multi-modal mutual information formula as a unified optimization target and demonstrate that all existing approaches are special cases of our framework. Under this unified perspective, we propose an all-in-one single-stage pre-training approach, named Maximizing Multi-modal Mutual Information Pre-training (M3I Pre-training). Our approach achieves better performance than previous pre-training methods on various vision benchmarks, including ImageNet classification, COCO object detection, LVIS long-tailed object detection, and ADE20k semantic segmentation. Notably, we successfully pre-train a billion-level parameter image backbone and achieve state-of-the-art performance on various benchmarks. Code shall be released at https://github.com/OpenGVLab/M3I-Pretraining.

Canada experienced in 2023 one of the most severe wildfire seasons in recent history, causing damage across ecosystems, destroying communities, and emitting large quantities of CO2. This extreme wildfire season is symptomatic of a climate-change-induced increase in the length and severity of the fire season that affects the boreal ecosystem. Therefore, it is critical to empower wildfire management in boreal communities with better mitigation solutions. Wildfire probability maps represent an important tool for understanding the likelihood of wildfire occurrence and the potential severity of future wildfires. The massive increase in the availability of Earth observation data has enabled the development of deep learning-based wildfire forecasting models, aiming at providing precise wildfire probability maps at different spatial and temporal scales. A main limitation of such methods is their reliance on coarse-resolution environmental drivers and satellite products, leading to wildfire occurrence prediction of reduced resolution, typically around sim 0.1{\deg}. This paper presents a benchmark dataset: CanadaFireSat, and baseline methods for high-resolution: 100 m wildfire forecasting across Canada, leveraging multi-modal data from high-resolution multi-spectral satellite images (Sentinel-2 L1C), mid-resolution satellite products (MODIS), and environmental factors (ERA5 reanalysis data). Our experiments consider two major deep learning architectures. We observe that using multi-modal temporal inputs outperforms single-modal temporal inputs across all metrics, achieving a peak performance of 60.3% in F1 score for the 2023 wildfire season, a season never seen during model training. This demonstrates the potential of multi-modal deep learning models for wildfire forecasting at high-resolution and continental scale.

Detecting out-of-distribution (OOD) samples is important for deploying machine learning models in safety-critical applications such as autonomous driving and robot-assisted surgery. Existing research has mainly focused on unimodal scenarios on image data. However, real-world applications are inherently multimodal, which makes it essential to leverage information from multiple modalities to enhance the efficacy of OOD detection. To establish a foundation for more realistic Multimodal OOD Detection, we introduce the first-of-its-kind benchmark, MultiOOD, characterized by diverse dataset sizes and varying modality combinations. We first evaluate existing unimodal OOD detection algorithms on MultiOOD, observing that the mere inclusion of additional modalities yields substantial improvements. This underscores the importance of utilizing multiple modalities for OOD detection. Based on the observation of Modality Prediction Discrepancy between in-distribution (ID) and OOD data, and its strong correlation with OOD performance, we propose the Agree-to-Disagree (A2D) algorithm to encourage such discrepancy during training. Moreover, we introduce a novel outlier synthesis method, NP-Mix, which explores broader feature spaces by leveraging the information from nearest neighbor classes and complements A2D to strengthen OOD detection performance. Extensive experiments on MultiOOD demonstrate that training with A2D and NP-Mix improves existing OOD detection algorithms by a large margin. Our source code and MultiOOD benchmark are available at https://github.com/donghao51/MultiOOD.

We propose the Multi-Head Gaussian Adaptive Attention Mechanism (GAAM), a novel probabilistic attention framework, and the Gaussian Adaptive Transformer (GAT), designed to enhance information aggregation across multiple modalities, including Speech, Text and Vision. GAAM integrates learnable mean and variance into its attention mechanism, implemented in a Multi-Headed framework enabling it to collectively model any Probability Distribution for dynamic recalibration of feature significance. This method demonstrates significant improvements, especially with highly non-stationary data, surpassing the state-of-the-art attention techniques in model performance (up to approximately +20% in accuracy) by identifying key elements within the feature space. GAAM's compatibility with dot-product-based attention models and relatively low number of parameters showcases its adaptability and potential to boost existing attention frameworks. Empirically, GAAM exhibits superior adaptability and efficacy across a diverse range of tasks, including emotion recognition in speech, image classification, and text classification, thereby establishing its robustness and versatility in handling multi-modal data. Furthermore, we introduce the Importance Factor (IF), a new learning-based metric that enhances the explainability of models trained with GAAM-based methods. Overall, GAAM represents an advancement towards development of better performing and more explainable attention models across multiple modalities.

Advancing machine intelligence requires developing the ability to perceive across multiple modalities, much as humans sense the world. We introduce OmniVinci, an initiative to build a strong, open-source, omni-modal LLM. We carefully study the design choices across model architecture and data curation. For model architecture, we present three key innovations: (i) OmniAlignNet for strengthening alignment between vision and audio embeddings in a shared omni-modal latent space; (ii) Temporal Embedding Grouping for capturing relative temporal alignment between vision and audio signals; and (iii) Constrained Rotary Time Embedding for encoding absolute temporal information in omni-modal embeddings. We introduce a curation and synthesis pipeline that generates 24M single-modal and omni-modal conversations. We find that modalities reinforce one another in both perception and reasoning. Our model, OmniVinci, outperforms Qwen2.5-Omni with +19.05 on DailyOmni (cross-modal understanding), +1.7 on MMAR (audio), and +3.9 on Video-MME (vision), while using just 0.2T training tokens - a 6 times reduction compared to Qwen2.5-Omni's 1.2T. We finally demonstrate omni-modal advantages in downstream applications spanning robotics, medical AI, and smart factory.

In many machine learning systems that jointly learn from multiple modalities, a core research question is to understand the nature of multimodal interactions: the emergence of new task-relevant information during learning from both modalities that was not present in either alone. We study this challenge of interaction quantification in a semi-supervised setting with only labeled unimodal data and naturally co-occurring multimodal data (e.g., unlabeled images and captions, video and corresponding audio) but when labeling them is time-consuming. Using a precise information-theoretic definition of interactions, our key contributions are the derivations of lower and upper bounds to quantify the amount of multimodal interactions in this semi-supervised setting. We propose two lower bounds based on the amount of shared information between modalities and the disagreement between separately trained unimodal classifiers, and derive an upper bound through connections to approximate algorithms for min-entropy couplings. We validate these estimated bounds and show how they accurately track true interactions. Finally, two semi-supervised multimodal applications are explored based on these theoretical results: (1) analyzing the relationship between multimodal performance and estimated interactions, and (2) self-supervised learning that embraces disagreement between modalities beyond agreement as is typically done.

Objective: To allow efficient learning using the Recurrent Inference Machine (RIM) for image reconstruction whereas not being strictly dependent on the training data distribution so that unseen modalities and pathologies are still accurately recovered. Methods: Theoretically, the RIM learns to solve the inverse problem of accelerated-MRI reconstruction whereas being robust to variable imaging conditions. The efficiency and generalization capabilities with different training datasets were studied, as well as recurrent network units with decreasing complexity: the Gated Recurrent Unit (GRU), the Minimal Gated Unit (MGU), and the Independently Recurrent Neural Network (IndRNN), to reduce inference times. Validation was performed against Compressed Sensing (CS) and further assessed based on data unseen during training. A pathology study was conducted by reconstructing simulated white matter lesions and prospectively undersampled data of a Multiple Sclerosis patient. Results: Training on a single modality of 3T T_1-weighted brain data appeared sufficient to also reconstruct 7T T_{2}^*-weighted brain and 3T T_2-weighted knee data. The IndRNN is an efficient recurrent unit, reducing inference time by 68\% compared to CS, whereas maintaining performance. The RIM was able to reconstruct lesions unseen during training more accurately than CS when trained on T_2-weighted knee data. Training on T_1-weighted brain data and on combined data slightly enhanced the signal compared to CS. Conclusion: The RIM is efficient when decreasing its complexity, which reduces the inference time, whereas still being able to reconstruct data and pathology that was unseen during training.

Humans possess the capability to comprehend diverse modalities and seamlessly transfer information between them. In this work, we introduce ModaVerse, a Multi-modal Large Language Model (MLLM) capable of comprehending and transforming content across various modalities including images, videos, and audio. Predominant MLLM frameworks have largely relied on the alignment of latent spaces of textual and non-textual features. This alignment process, which synchronizes a language model trained on textual data with encoders and decoders trained on multi-modal data, often necessitates extensive training of several projection layers in multiple stages. Inspired by LLM-as-agent methodologies, we propose a novel Input/Output (I/O) alignment mechanism that operates directly at the level of natural language. It aligns the LLM's output with the input of generative models, avoiding the complexities associated with latent feature alignments, and simplifying the multiple training stages of existing MLLMs into a single, efficient process. This conceptual advancement leads to significant reductions in both data and computational costs. By conducting experiments on several benchmarks, we demonstrate that our approach attains comparable performance with the state of the art while achieving considerable efficiencies in data usage and training duration.

Data collected from the real world tends to be biased, unbalanced, and at risk of exposing sensitive and private information. This reality has given rise to the idea of creating synthetic datasets to alleviate risk, bias, harm, and privacy concerns inherent in the real data. This concept relies on Generative AI models to produce unbiased, privacy-preserving synthetic data while being true to the real data. In this new paradigm, how can we tell if this approach delivers on its promises? We present an auditing framework that offers a holistic assessment of synthetic datasets and AI models trained on them, centered around bias and discrimination prevention, fidelity to the real data, utility, robustness, and privacy preservation. We showcase our framework by auditing multiple generative models on diverse use cases, including education, healthcare, banking, human resources, and across different modalities, from tabular, to time-series, to natural language. Our use cases demonstrate the importance of a holistic assessment in order to ensure compliance with socio-technical safeguards that regulators and policymakers are increasingly enforcing. For this purpose, we introduce the trust index that ranks multiple synthetic datasets based on their prescribed safeguards and their desired trade-offs. Moreover, we devise a trust-index-driven model selection and cross-validation procedure via auditing in the training loop that we showcase on a class of transformer models that we dub TrustFormers, across different modalities. This trust-driven model selection allows for controllable trust trade-offs in the resulting synthetic data. We instrument our auditing framework with workflows that connect different stakeholders from model development to audit and certification via a synthetic data auditing report.

Self-supervised representation learning follows a paradigm of withholding some part of the data and tasking the network to predict it from the remaining part. Among many techniques, data augmentation lies at the core for creating the information gap. Towards this end, masking has emerged as a generic and powerful tool where content is withheld along the sequential dimension, e.g., spatial in images, temporal in audio, and syntactic in language. In this paper, we explore the orthogonal channel dimension for generic data augmentation by exploiting precision redundancy. The data for each channel is quantized through a non-uniform quantizer, with the quantized value sampled randomly within randomly sampled quantization bins. From another perspective, quantization is analogous to channel-wise masking, as it removes the information within each bin, but preserves the information across bins. Our approach significantly surpasses existing generic data augmentation methods, while showing on par performance against modality-specific augmentations. We comprehensively evaluate our approach on vision, audio, 3D point clouds, as well as the DABS benchmark which is comprised of various data modalities. The code is available at https: //github.com/microsoft/random_quantize.

Geospatial raster data, such as that collected by satellite-based imaging systems at different times and spectral bands, hold immense potential for enabling a wide range of high-impact applications. This potential stems from the rich information that is spatially and temporally contextualized across multiple channels and sensing modalities. Recent work has adapted existing self-supervised learning approaches for such geospatial data. However, they fall short of scalable model architectures, leading to inflexibility and computational inefficiencies when faced with an increasing number of channels and modalities. To address these limitations, we introduce Low-rank Efficient Spatial-Spectral Vision Transformer with three key innovations: i) the LESS Attention Block that approximates high-dimensional spatial-spectral attention through Kronecker's product of the low-dimensional spatial and spectral attention components; ii) the Continuous Positional-Channel Embedding Layer that preserves both the continuity and physical characteristics of each spatial-spectral patch; and iii) the Perception Field Mask that exploits local spatial dependencies by constraining attention to neighboring patches. To evaluate the proposed innovations, we construct GFM-Bench, which serves as a comprehensive benchmark for such geospatial raster data. We pretrain LESS ViT using a Hyperspectral Masked Autoencoder framework with integrated positional and channel masking strategies. Experimental results demonstrate that our proposed method achieves competitive performance against state-of-the-art multi-modal geospatial foundation models while outperforming them on cross-satellite generalization tasks with higher computational efficiency. The flexibility and extensibility of our framework make it a promising direction for future geospatial data analysis tasks that involve a wide range of modalities and channels.

The rapid progression of multimodal large language models (MLLMs) has demonstrated superior performance on various multimodal benchmarks. However, the issue of data contamination during training creates challenges in performance evaluation and comparison. While numerous methods exist for detecting dataset contamination in large language models (LLMs), they are less effective for MLLMs due to their various modalities and multiple training phases. In this study, we introduce a multimodal data contamination detection framework, MM-Detect, designed for MLLMs. Our experimental results indicate that MM-Detect is sensitive to varying degrees of contamination and can highlight significant performance improvements due to leakage of the training set of multimodal benchmarks. Furthermore, We also explore the possibility of contamination originating from the pre-training phase of LLMs used by MLLMs and the fine-tuning phase of MLLMs, offering new insights into the stages at which contamination may be introduced.

For centuries, researchers have sought out ways to connect disparate areas of knowledge. While early scholars (Galileo, da Vinci, etc.) were experts across fields, specialization has taken hold later. With the advent of Artificial Intelligence, we can now explore relationships across areas (e.g., mechanics-biology) or disparate domains (e.g., failure mechanics-art). To achieve this, we use a fine-tuned Large Language Model (LLM), here for a subset of knowledge in multiscale materials failure. The approach includes the use of a general-purpose LLM to distill question-answer pairs from raw sources followed by LLM fine-tuning. The resulting MechGPT LLM foundation model is used in a series of computational experiments to explore its capacity for knowledge retrieval, various language tasks, hypothesis generation, and connecting knowledge across disparate areas. While the model has some ability to recall knowledge from training, we find that LLMs are particularly useful to extract structural insights through Ontological Knowledge Graphs. These interpretable graph structures provide explanatory insights, frameworks for new research questions, and visual representations of knowledge that also can be used in retrieval-augmented generation. Three versions of MechGPT are discussed, featuring different sizes from 13 billion to 70 billion parameters, and reaching context lengths of more than 10,000 tokens. This provides ample capacity for sophisticated retrieval augmented strategies, as well as agent-based modeling where multiple LLMs interact collaboratively and/or adversarially, the incorporation of new data from the literature or web searches, as well as multimodality.

User data spread across multiple modalities has popularized multi-modal recommender systems (MMRS). They recommend diverse content such as products, social media posts, TikTok reels, etc., based on a user-item interaction graph. With rising data privacy demands, recent methods propose unlearning private user data from uni-modal recommender systems (RS). However, methods for unlearning item data related to outdated user preferences, revoked licenses, and legally requested removals are still largely unexplored. Previous RS unlearning methods are unsuitable for MMRS due to the incompatibility of their matrix-based representation with the multi-modal user-item interaction graph. Moreover, their data partitioning step degrades performance on each shard due to poor data heterogeneity and requires costly performance aggregation across shards. This paper introduces MMRecUn, the first approach known to us for unlearning in MMRS and unlearning item data. Given a trained RS model, MMRecUn employs a novel Reverse Bayesian Personalized Ranking (BPR) objective to enable the model to forget marked data. The reverse BPR attenuates the impact of user-item interactions within the forget set, while the forward BPR reinforces the significance of user-item interactions within the retain set. Our experiments demonstrate that MMRecUn outperforms baseline methods across various unlearning requests when evaluated on benchmark MMRS datasets. MMRecUn achieves recall performance improvements of up to 49.85% compared to baseline methods and is up to 1.3x faster than the Gold model, which is trained on retain set from scratch. MMRecUn offers significant advantages, including superiority in removing target interactions, preserving retained interactions, and zero overhead costs compared to previous methods. Code: https://github.com/MachineUnlearn/MMRecUN Extended version: arXiv:2405.15328

Data balancing across multiple modalities and sources appears in various forms in foundation models in machine learning and AI, e.g. in CLIP and DINO. We show that data balancing across modalities and sources actually offers an unsuspected benefit: variance reduction. We present a non-asymptotic statistical bound that quantifies this variance reduction effect and relates it to the eigenvalue decay of Markov operators. Furthermore, we describe how various forms of data balancing in contrastive multimodal learning and self-supervised clustering can be better understood, and even improved upon, owing to our variance reduction viewpoint.

Machine learning models often struggle with distribution shifts in real-world scenarios, whereas humans exhibit robust adaptation. Models that better align with human perception may achieve higher out-of-distribution generalization. In this study, we investigate how various characteristics of large-scale computer vision models influence their alignment with human capabilities and robustness. Our findings indicate that increasing model and data size and incorporating rich semantic information and multiple modalities enhance models' alignment with human perception and their overall robustness. Our empirical analysis demonstrates a strong correlation between out-of-distribution accuracy and human alignment.

Mainstream parameter-efficient fine-tuning (PEFT) methods, such as LoRA or Adapter, project a model's hidden states to a lower dimension, allowing pre-trained models to adapt to new data through this low-rank bottleneck. However, PEFT tasks involving multiple modalities, like vision-language (VL) tasks, require not only adaptation to new data but also learning the relationship between different modalities. Targeting at VL PEFT tasks, we propose a family of operations, called routing functions, to enhance VL alignment in the low-rank bottlenecks. The routing functions adopt linear operations and do not introduce new trainable parameters. In-depth analyses are conducted to study their behavior. In various VL PEFT settings, the routing functions significantly improve performance of the original PEFT methods, achieving over 20% improvement on VQAv2 (RoBERTa_{large}+ViT-L/16) and 30% on COCO Captioning (GPT2-medium+ViT-L/16). Also when fine-tuning a pre-trained multimodal model such as CLIP-BART, we observe smaller but consistent improvements across a range of VL PEFT tasks.

Following its success for vision and text, the "foundation model" (FM) paradigm -- pretraining large models on massive data, then fine-tuning on target tasks -- has rapidly expanded to domains in the sciences, engineering, healthcare, and beyond. Has this achieved what the original FMs accomplished, i.e. the supplanting of traditional supervised learning in their domains? To answer we look at three modalities -- genomics, satellite imaging, and time series -- with multiple recent FMs and compare them to a standard supervised learning workflow: model development, hyperparameter tuning, and training, all using only data from the target task. Across these three specialized domains, we find that it is consistently possible to train simple supervised models -- no more complicated than a lightly modified wide ResNet or UNet -- that match or even outperform the latest foundation models. Our work demonstrates that the benefits of large-scale pretraining have yet to be realized in many specialized areas, reinforces the need to compare new FMs to strong, well-tuned baselines, and introduces two new, easy-to-use, open-source, and automated workflows for doing so.

Foundation models have shown remarkable success across scientific domains, yet their impact in chemistry remains limited due to the absence of diverse, large-scale, high-quality datasets that reflect the field's multifaceted nature. We present the ChemPile, an open dataset containing over 75 billion tokens of curated chemical data, specifically built for training and evaluating general-purpose models in the chemical sciences. The dataset mirrors the human learning journey through chemistry -- from educational foundations to specialized expertise -- spanning multiple modalities and content types including structured data in diverse chemical representations (SMILES, SELFIES, IUPAC names, InChI, molecular renderings), scientific and educational text, executable code, and chemical images. ChemPile integrates foundational knowledge (textbooks, lecture notes), specialized expertise (scientific articles and language-interfaced data), visual understanding (molecular structures, diagrams), and advanced reasoning (problem-solving traces and code) -- mirroring how human chemists develop expertise through diverse learning materials and experiences. Constructed through hundreds of hours of expert curation, the ChemPile captures both foundational concepts and domain-specific complexity. We provide standardized training, validation, and test splits, enabling robust benchmarking. ChemPile is openly released via HuggingFace with a consistent API, permissive license, and detailed documentation. We hope the ChemPile will serve as a catalyst for chemical AI, enabling the development of the next generation of chemical foundation models.

Out-of-distribution (OOD) detection and segmentation are crucial for deploying machine learning models in safety-critical applications such as autonomous driving and robot-assisted surgery. While prior research has primarily focused on unimodal image data, real-world applications are inherently multimodal, requiring the integration of multiple modalities for improved OOD detection. A key challenge is the lack of supervision signals from unknown data, leading to overconfident predictions on OOD samples. To address this challenge, we propose Feature Mixing, an extremely simple and fast method for multimodal outlier synthesis with theoretical support, which can be further optimized to help the model better distinguish between in-distribution (ID) and OOD data. Feature Mixing is modality-agnostic and applicable to various modality combinations. Additionally, we introduce CARLA-OOD, a novel multimodal dataset for OOD segmentation, featuring synthetic OOD objects across diverse scenes and weather conditions. Extensive experiments on SemanticKITTI, nuScenes, CARLA-OOD datasets, and the MultiOOD benchmark demonstrate that Feature Mixing achieves state-of-the-art performance with a 10 times to 370 times speedup. Our source code and dataset will be available at https://github.com/mona4399/FeatureMixing.

We present the Multiview Extended Video with Activities (MEVA) dataset, a new and very-large-scale dataset for human activity recognition. Existing security datasets either focus on activity counts by aggregating public video disseminated due to its content, which typically excludes same-scene background video, or they achieve persistence by observing public areas and thus cannot control for activity content. Our dataset is over 9300 hours of untrimmed, continuous video, scripted to include diverse, simultaneous activities, along with spontaneous background activity. We have annotated 144 hours for 37 activity types, marking bounding boxes of actors and props. Our collection observed approximately 100 actors performing scripted scenarios and spontaneous background activity over a three-week period at an access-controlled venue, collecting in multiple modalities with overlapping and non-overlapping indoor and outdoor viewpoints. The resulting data includes video from 38 RGB and thermal IR cameras, 42 hours of UAV footage, as well as GPS locations for the actors. 122 hours of annotation are sequestered in support of the NIST Activity in Extended Video (ActEV) challenge; the other 22 hours of annotation and the corresponding video are available on our website, along with an additional 306 hours of ground camera data, 4.6 hours of UAV data, and 9.6 hours of GPS logs. Additional derived data includes camera models geo-registering the outdoor cameras and a dense 3D point cloud model of the outdoor scene. The data was collected with IRB oversight and approval and released under a CC-BY-4.0 license.

The goal of diffusion generative models is to align the learned distribution with the real data distribution through gradient score matching. However, inherent limitations in training data quality, modeling strategies, and architectural design lead to inevitable gap between generated outputs and real data. To reduce this gap, we propose Weak-to-Strong Diffusion (W2SD), a novel framework that utilizes the estimated difference between existing weak and strong models (i.e., weak-to-strong difference) to approximate the gap between an ideal model and a strong model. By employing a reflective operation that alternates between denoising and inversion with weak-to-strong difference, we theoretically understand that W2SD steers latent variables along sampling trajectories toward regions of the real data distribution. W2SD is highly flexible and broadly applicable, enabling diverse improvements through the strategic selection of weak-to-strong model pairs (e.g., DreamShaper vs. SD1.5, good experts vs. bad experts in MoE). Extensive experiments demonstrate that W2SD significantly improves human preference, aesthetic quality, and prompt adherence, achieving SOTA performance across various modalities (e.g., image, video), architectures (e.g., UNet-based, DiT-based, MoE), and benchmarks. For example, Juggernaut-XL with W2SD can improve with the HPSv2 winning rate up to 90% over the original results. Moreover, the performance gains achieved by W2SD markedly outweigh its additional computational overhead, while the cumulative improvements from different weak-to-strong difference further solidify its practical utility and deployability.

The integration of artificial intelligence in image-guided interventions holds transformative potential, promising to extract 3D geometric and quantitative information from conventional 2D imaging modalities during complex procedures. Achieving this requires the rapid and precise alignment of 2D intraoperative images (e.g., X-ray) with 3D preoperative volumes (e.g., CT, MRI). However, current 2D/3D registration methods fail across the broad spectrum of procedures dependent on X-ray guidance: traditional optimization techniques require custom parameter tuning for each subject, whereas neural networks trained on small datasets do not generalize to new patients or require labor-intensive manual annotations, increasing clinical burden and precluding application to new anatomical targets. To address these challenges, we present xvr, a fully automated framework for training patient-specific neural networks for 2D/3D registration. xvr uses physics-based simulation to generate abundant high-quality training data from a patient's own preoperative volumetric imaging, thereby overcoming the inherently limited ability of supervised models to generalize to new patients and procedures. Furthermore, xvr requires only 5 minutes of training per patient, making it suitable for emergency interventions as well as planned procedures. We perform the largest evaluation of a 2D/3D registration algorithm on real X-ray data to date and find that xvr robustly generalizes across a diverse dataset comprising multiple anatomical structures, imaging modalities, and hospitals. Across surgical tasks, xvr achieves submillimeter-accurate registration at intraoperative speeds, improving upon existing methods by an order of magnitude. xvr is released as open-source software freely available at https://github.com/eigenvivek/xvr.

Image matching for both cross-view and cross-modality plays a critical role in multimodal perception. In practice, the modality gap caused by different imaging systems/styles poses great challenges to the matching task. Existing works try to extract invariant features for specific modalities and train on limited datasets, showing poor generalization. In this paper, we present MINIMA, a unified image matching framework for multiple cross-modal cases. Without pursuing fancy modules, our MINIMA aims to enhance universal performance from the perspective of data scaling up. For such purpose, we propose a simple yet effective data engine that can freely produce a large dataset containing multiple modalities, rich scenarios, and accurate matching labels. Specifically, we scale up the modalities from cheap but rich RGB-only matching data, by means of generative models. Under this setting, the matching labels and rich diversity of the RGB dataset are well inherited by the generated multimodal data. Benefiting from this, we construct MD-syn, a new comprehensive dataset that fills the data gap for general multimodal image matching. With MD-syn, we can directly train any advanced matching pipeline on randomly selected modality pairs to obtain cross-modal ability. Extensive experiments on in-domain and zero-shot matching tasks, including 19 cross-modal cases, demonstrate that our MINIMA can significantly outperform the baselines and even surpass modality-specific methods. The dataset and code are available at https://github.com/LSXI7/MINIMA .

Predicting multiple real-world tasks in a single model often requires a particularly diverse feature space. Multimodal (MM) models aim to extract the synergistic predictive potential of multiple data types to create a shared feature space with aligned semantic meaning across inputs of drastically varying sizes (i.e. images, text, sound). Most current MM architectures fuse these representations in parallel, which not only limits their interpretability but also creates a dependency on modality availability. We present MultiModN, a multimodal, modular network that fuses latent representations in a sequence of any number, combination, or type of modality while providing granular real-time predictive feedback on any number or combination of predictive tasks. MultiModN's composable pipeline is interpretable-by-design, as well as innately multi-task and robust to the fundamental issue of biased missingness. We perform four experiments on several benchmark MM datasets across 10 real-world tasks (predicting medical diagnoses, academic performance, and weather), and show that MultiModN's sequential MM fusion does not compromise performance compared with a baseline of parallel fusion. By simulating the challenging bias of missing not-at-random (MNAR), this work shows that, contrary to MultiModN, parallel fusion baselines erroneously learn MNAR and suffer catastrophic failure when faced with different patterns of MNAR at inference. To the best of our knowledge, this is the first inherently MNAR-resistant approach to MM modeling. In conclusion, MultiModN provides granular insights, robustness, and flexibility without compromising performance.

Human-generated reward signals are critical for aligning generative models with human preferences, guiding both training and inference-time evaluations. While large language models (LLMs) employed as proxy evaluators, i.e., LLM-as-a-Judge, significantly reduce the costs associated with manual annotations, they typically require extensive modality-specific training data and fail to generalize well across diverse multimodal tasks. In this paper, we propose Flex-Judge, a reasoning-guided multimodal judge model that leverages minimal textual reasoning data to robustly generalize across multiple modalities and evaluation formats. Our core intuition is that structured textual reasoning explanations inherently encode generalizable decision-making patterns, enabling an effective transfer to multimodal judgments, e.g., with images or videos. Empirical results demonstrate that Flex-Judge, despite being trained on significantly fewer text data, achieves competitive or superior performance compared to state-of-the-art commercial APIs and extensively trained multimodal evaluators. Notably, Flex-Judge presents broad impact in modalities like molecule, where comprehensive evaluation benchmarks are scarce, underscoring its practical value in resource-constrained domains. Our framework highlights reasoning-based text supervision as a powerful, cost-effective alternative to traditional annotation-intensive approaches, substantially advancing scalable multimodal model-as-a-judge.

In remote sensing, multi-modal data from various sensors capturing the same scene offers rich opportunities, but learning a unified representation across these modalities remains a significant challenge. Traditional methods have often been limited to single or dual-modality approaches. In this paper, we introduce COP-GEN-Beta, a generative diffusion model trained on optical, radar, and elevation data from the Major TOM dataset. What sets COP-GEN-Beta apart is its ability to map any subset of modalities to any other, enabling zero-shot modality translation after training. This is achieved through a sequence-based diffusion transformer, where each modality is controlled by its own timestep embedding. We extensively evaluate COP-GEN-Beta on thumbnail images from the Major TOM dataset, demonstrating its effectiveness in generating high-quality samples. Qualitative and quantitative evaluations validate the model's performance, highlighting its potential as a powerful pre-trained model for future remote sensing tasks.

Deep Learning (DL) has the potential to optimize machine learning in both the scientific and clinical communities. However, greater expertise is required to develop DL algorithms, and the variability of implementations hinders their reproducibility, translation, and deployment. Here we present the community-driven Generally Nuanced Deep Learning Framework (GaNDLF), with the goal of lowering these barriers. GaNDLF makes the mechanism of DL development, training, and inference more stable, reproducible, interpretable, and scalable, without requiring an extensive technical background. GaNDLF aims to provide an end-to-end solution for all DL-related tasks in computational precision medicine. We demonstrate the ability of GaNDLF to analyze both radiology and histology images, with built-in support for k-fold cross-validation, data augmentation, multiple modalities and output classes. Our quantitative performance evaluation on numerous use cases, anatomies, and computational tasks supports GaNDLF as a robust application framework for deployment in clinical workflows.

In this work, we construct the largest dataset for multimodal pretraining in Chinese, which consists of over 1.9TB images and 292GB texts that cover a wide range of domains. We propose a cross-modal pretraining method called M6, referring to Multi-Modality to Multi-Modality Multitask Mega-transformer, for unified pretraining on the data of single modality and multiple modalities. We scale the model size up to 10 billion and 100 billion parameters, and build the largest pretrained model in Chinese. We apply the model to a series of downstream applications, and demonstrate its outstanding performance in comparison with strong baselines. Furthermore, we specifically design a downstream task of text-guided image generation, and show that the finetuned M6 can create high-quality images with high resolution and abundant details.

In the marketing field, understanding consumer heterogeneity, which is the internal or psychological difference among consumers that cannot be captured by behavioral logs, has long been a critical challenge. However, a number of consumers today usually post their evaluation on the specific product on the online platform, which can be the valuable source of such unobservable differences among consumers. Several previous studies have shown the validity of the analysis on text modality, but on the other hand, such analyses may not necessarily demonstrate sufficient predictive accuracy for text alone, as they may not include information readily available from cross-sectional data, such as consumer profile data. In addition, recent advances in machine learning techniques, such as large-scale language models (LLMs) and multimodal learning have made it possible to deal with the various kind of dataset simultaneously, including textual data and the traditional cross-sectional data, and the joint representations can be effectively obtained from multiple modalities. Therefore, this study constructs a product evaluation model that takes into account consumer heterogeneity by multimodal learning of online product reviews and consumer profile information. We also compare multiple models using different modalities or hyper-parameters to demonstrate the robustness of multimodal learning in marketing analysis.

Multimodal learning is a rapidly growing research field that has revolutionized multitasking and generative modeling in AI. While much of the research has focused on dealing with unstructured data (e.g., language, images, audio, or video), structured data (e.g., tabular data, time series, or signals) has received less attention. However, many industry-relevant use cases involve or can be benefited from both types of data. In this work, we propose a modular, end-to-end multimodal learning method called MAGNUM, which can natively handle both structured and unstructured data. MAGNUM is flexible enough to employ any specialized unimodal module to extract, compress, and fuse information from all available modalities.

Our experience of the world is multimodal - we see objects, hear sounds, feel texture, smell odors, and taste flavors. Modality refers to the way in which something happens or is experienced and a research problem is characterized as multimodal when it includes multiple such modalities. In order for Artificial Intelligence to make progress in understanding the world around us, it needs to be able to interpret such multimodal signals together. Multimodal machine learning aims to build models that can process and relate information from multiple modalities. It is a vibrant multi-disciplinary field of increasing importance and with extraordinary potential. Instead of focusing on specific multimodal applications, this paper surveys the recent advances in multimodal machine learning itself and presents them in a common taxonomy. We go beyond the typical early and late fusion categorization and identify broader challenges that are faced by multimodal machine learning, namely: representation, translation, alignment, fusion, and co-learning. This new taxonomy will enable researchers to better understand the state of the field and identify directions for future research.

Multimodal information retrieval (MIR) faces inherent challenges due to the heterogeneity of data sources and the complexity of cross-modal alignment. While previous studies have identified modal gaps in feature spaces, a systematic approach to address these challenges remains unexplored. In this work, we introduce UNITE, a universal framework that tackles these challenges through two critical yet underexplored aspects: data curation and modality-aware training configurations. Our work provides the first comprehensive analysis of how modality-specific data properties influence downstream task performance across diverse scenarios. Moreover, we propose Modal-Aware Masked Contrastive Learning (MAMCL) to mitigate the competitive relationships among the instances of different modalities. Our framework achieves state-of-the-art results on multiple multimodal retrieval benchmarks, outperforming existing methods by notable margins. Through extensive experiments, we demonstrate that strategic modality curation and tailored training protocols are pivotal for robust cross-modal representation learning. This work not only advances MIR performance but also provides a foundational blueprint for future research in multimodal systems. Our project is available at https://friedrichor.github.io/projects/UNITE.

This book is the result of a seminar in which we reviewed multimodal approaches and attempted to create a solid overview of the field, starting with the current state-of-the-art approaches in the two subfields of Deep Learning individually. Further, modeling frameworks are discussed where one modality is transformed into the other, as well as models in which one modality is utilized to enhance representation learning for the other. To conclude the second part, architectures with a focus on handling both modalities simultaneously are introduced. Finally, we also cover other modalities as well as general-purpose multi-modal models, which are able to handle different tasks on different modalities within one unified architecture. One interesting application (Generative Art) eventually caps off this booklet.

Biomedical data is inherently multimodal, consisting of electronic health records, medical imaging, digital pathology, genome sequencing, wearable sensors, and more. The application of artificial intelligence tools to these multifaceted sensing technologies has the potential to revolutionize the prognosis, diagnosis, and management of human health and disease. However, current approaches to biomedical AI typically only train and evaluate with one or a small set of medical modalities and tasks. This limitation hampers the development of comprehensive tools that can leverage the rich interconnected information across many heterogeneous biomedical sensors. To address this challenge, we present MultiMed, a benchmark designed to evaluate and enable large-scale learning across a wide spectrum of medical modalities and tasks. MultiMed consists of 2.56 million samples across ten medical modalities such as medical reports, pathology, genomics, and protein data, and is structured into eleven challenging tasks, including disease prognosis, protein structure prediction, and medical question answering. Using MultiMed, we conduct comprehensive experiments benchmarking state-of-the-art unimodal, multimodal, and multitask models. Our analysis highlights the advantages of training large-scale medical models across many related modalities and tasks. Moreover, MultiMed enables studies of generalization across related medical concepts, robustness to real-world noisy data and distribution shifts, and novel modality combinations to improve prediction performance. MultiMed will be publicly available and regularly updated and welcomes inputs from the community.

Contrastive learning methods, such as CLIP, leverage naturally paired data-for example, images and their corresponding text captions-to learn general representations that transfer efficiently to downstream tasks. While such approaches are generally applied to two modalities, domains such as robotics, healthcare, and video need to support many types of data at once. We show that the pairwise application of CLIP fails to capture joint information between modalities, thereby limiting the quality of the learned representations. To address this issue, we present Symile, a simple contrastive learning approach that captures higher-order information between any number of modalities. Symile provides a flexible, architecture-agnostic objective for learning modality-specific representations. To develop Symile's objective, we derive a lower bound on total correlation, and show that Symile representations for any set of modalities form a sufficient statistic for predicting the remaining modalities. Symile outperforms pairwise CLIP, even with modalities missing in the data, on cross-modal classification and retrieval across several experiments including on an original multilingual dataset of 33M image, text and audio samples and a clinical dataset of chest X-rays, electrocardiograms, and laboratory measurements. All datasets and code used in this work are publicly available at https://github.com/rajesh-lab/symile.

Sequential recommendations have drawn significant attention in modeling the user's historical behaviors to predict the next item. With the booming development of multimodal data (e.g., image, text) on internet platforms, sequential recommendation also benefits from the incorporation of multimodal data. Most methods introduce modal features of items as side information and simply concatenates them to learn unified user interests. Nevertheless, these methods encounter the limitation in modeling multimodal differences. We argue that user interests and item relationships vary across different modalities. To address this problem, we propose a novel Multimodal Difference Learning framework for Sequential Recommendation, MDSRec for brevity. Specifically, we first explore the differences in item relationships by constructing modal-aware item relation graphs with behavior signal to enhance item representations. Then, to capture the differences in user interests across modalities, we design a interest-centralized attention mechanism to independently model user sequence representations in different modalities. Finally, we fuse the user embeddings from multiple modalities to achieve accurate item recommendation. Experimental results on five real-world datasets demonstrate the superiority of MDSRec over state-of-the-art baselines and the efficacy of multimodal difference learning.

Retrieval-Augmented Generation (RAG) has shown substantial promise in improving factual accuracy by grounding model responses with external knowledge relevant to queries. However, most existing RAG approaches are limited to a text-only corpus, and while recent efforts have extended RAG to other modalities such as images and videos, they typically operate over a single modality-specific corpus. In contrast, real-world queries vary widely in the type of knowledge they require, which a single type of knowledge source cannot address. To address this, we introduce UniversalRAG, a novel RAG framework designed to retrieve and integrate knowledge from heterogeneous sources with diverse modalities and granularities. Specifically, motivated by the observation that forcing all modalities into a unified representation space derived from a single combined corpus causes a modality gap, where the retrieval tends to favor items from the same modality as the query, we propose a modality-aware routing mechanism that dynamically identifies the most appropriate modality-specific corpus and performs targeted retrieval within it. Also, beyond modality, we organize each modality into multiple granularity levels, enabling fine-tuned retrieval tailored to the complexity and scope of the query. We validate UniversalRAG on 8 benchmarks spanning multiple modalities, showing its superiority over modality-specific and unified baselines.

There is increasing interest in the use of multimodal data in various web applications, such as digital advertising and e-commerce. Typical methods for extracting important information from multimodal data rely on a mid-fusion architecture that combines the feature representations from multiple encoders. However, as the number of modalities increases, several potential problems with the mid-fusion model structure arise, such as an increase in the dimensionality of the concatenated multimodal features and missing modalities. To address these problems, we propose a new concept that considers multimodal inputs as a set of sequences, namely, deep multimodal sequence sets (DM^2S^2). Our set-aware concept consists of three components that capture the relationships among multiple modalities: (a) a BERT-based encoder to handle the inter- and intra-order of elements in the sequences, (b) intra-modality residual attention (IntraMRA) to capture the importance of the elements in a modality, and (c) inter-modality residual attention (InterMRA) to enhance the importance of elements with modality-level granularity further. Our concept exhibits performance that is comparable to or better than the previous set-aware models. Furthermore, we demonstrate that the visualization of the learned InterMRA and IntraMRA weights can provide an interpretation of the prediction results.

Alzheimer's disease (AD) is a common neurodegenerative disease among the elderly. Early prediction and timely intervention of its prodromal stage, mild cognitive impairment (MCI), can decrease the risk of advancing to AD. Combining information from various modalities can significantly improve predictive accuracy. However, challenges such as missing data and heterogeneity across modalities complicate multimodal learning methods as adding more modalities can worsen these issues. Current multimodal fusion techniques often fail to adapt to the complexity of medical data, hindering the ability to identify relationships between modalities. To address these challenges, we propose an innovative multimodal approach for predicting MCI conversion, focusing specifically on the issues of missing positron emission tomography (PET) data and integrating diverse medical information. The proposed incomplete triple-modal MCI conversion prediction network is tailored for this purpose. Through the missing modal generation module, we synthesize the missing PET data from the magnetic resonance imaging and extract features using specifically designed encoders. We also develop a channel aggregation module and a triple-modal co-attention fusion module to reduce feature redundancy and achieve effective multimodal data fusion. Furthermore, we design a loss function to handle missing modality issues and align cross-modal features. These components collectively harness multimodal data to boost network performance. Experimental results on the ADNI1 and ADNI2 datasets show that our method significantly surpasses existing unimodal and other multimodal models. Our code is available at https://github.com/justinhxy/ITFC.

The rise in loosely-structured data available through text, images, and other modalities has called for new ways of querying them. Multimedia Information Retrieval has filled this gap and has witnessed exciting progress in recent years. Tasks such as search and retrieval of extensive multimedia archives have undergone massive performance improvements, driven to a large extent by recent developments in multimodal deep learning. However, methods in this field remain limited in the kinds of queries they support and, in particular, their inability to answer database-like queries. For this reason, inspired by recent work on neural databases, we propose a new framework, which we name Multimodal Neural Databases (MMNDBs). MMNDBs can answer complex database-like queries that involve reasoning over different input modalities, such as text and images, at scale. In this paper, we present the first architecture able to fulfill this set of requirements and test it with several baselines, showing the limitations of currently available models. The results show the potential of these new techniques to process unstructured data coming from different modalities, paving the way for future research in the area. Code to replicate the experiments will be released at https://github.com/GiovanniTRA/MultimodalNeuralDatabases

We present the MULTIMODAL UNIVERSE, a large-scale multimodal dataset of scientific astronomical data, compiled specifically to facilitate machine learning research. Overall, the MULTIMODAL UNIVERSE contains hundreds of millions of astronomical observations, constituting 100\,TB of multi-channel and hyper-spectral images, spectra, multivariate time series, as well as a wide variety of associated scientific measurements and "metadata". In addition, we include a range of benchmark tasks representative of standard practices for machine learning methods in astrophysics. This massive dataset will enable the development of large multi-modal models specifically targeted towards scientific applications. All codes used to compile the MULTIMODAL UNIVERSE and a description of how to access the data is available at https://github.com/MultimodalUniverse/MultimodalUniverse

Multimodal embedding models have gained significant attention for their ability to map data from different modalities, such as text and images, into a unified representation space. However, the limited labeled multimodal data often hinders embedding performance. Recent approaches have leveraged data synthesis to address this problem, yet the quality of synthetic data remains a critical bottleneck. In this work, we identify three criteria for high-quality synthetic multimodal data. First, broad scope ensures that the generated data covers diverse tasks and modalities, making it applicable to various downstream scenarios. Second, robust cross-modal alignment makes different modalities semantically consistent. Third, high fidelity ensures that the synthetic data maintains realistic details to enhance its reliability. Guided by these principles, we synthesize datasets that: (1) cover a wide range of tasks, modality combinations, and languages, (2) are generated via a deep thinking process within a single pass of a multimodal large language model, and (3) incorporate real-world images with accurate and relevant texts, ensuring fidelity through self-evaluation and refinement. Leveraging these high-quality synthetic and labeled datasets, we train a multimodal multilingual E5 model mmE5. Extensive experiments demonstrate that mmE5 achieves state-of-the-art performance on the MMEB Benchmark and superior multilingual performance on the XTD benchmark. Our codes, datasets and models are released in https://github.com/haon-chen/mmE5.

The rapid development of large language models (LLMs) has been witnessed in recent years. Based on the powerful LLMs, multi-modal LLMs (MLLMs) extend the modality from text to a broader spectrum of domains, attracting widespread attention due to the broader range of application scenarios. As LLMs and MLLMs rely on vast amounts of model parameters and data to achieve emergent capabilities, the importance of data is receiving increasingly widespread attention and recognition. Tracing and analyzing recent data-oriented works for MLLMs, we find that the development of models and data is not two separate paths but rather interconnected. On the one hand, vaster and higher-quality data contribute to better performance of MLLMs, on the other hand, MLLMs can facilitate the development of data. The co-development of multi-modal data and MLLMs requires a clear view of 1) at which development stage of MLLMs can specific data-centric approaches be employed to enhance which capabilities, and 2) by utilizing which capabilities and acting as which roles can models contribute to multi-modal data. To promote the data-model co-development for MLLM community, we systematically review existing works related to MLLMs from the data-model co-development perspective. A regularly maintained project associated with this survey is accessible at https://github.com/modelscope/data-juicer/blob/main/docs/awesome_llm_data.md.

Brain MRI scans are often found in four modalities, consisting of T1-weighted with and without contrast enhancement (T1ce and T1w), T2-weighted imaging (T2w), and Flair. Leveraging complementary information from these different modalities enables models to learn richer, more discriminative features for understanding brain anatomy, which could be used in downstream tasks such as anomaly detection. However, in clinical practice, not all MRI modalities are always available due to various reasons. This makes missing modality generation a critical challenge in medical image analysis. In this paper, we propose SLaM-DiMM, a novel missing modality generation framework that harnesses the power of diffusion models to synthesize any of the four target MRI modalities from other available modalities. Our approach not only generates high-fidelity images but also ensures structural coherence across the depth of the volume through a dedicated coherence enhancement mechanism. Qualitative and quantitative evaluations on the BraTS-Lighthouse-2025 Challenge dataset demonstrate the effectiveness of the proposed approach in synthesizing anatomically plausible and structurally consistent results. Code is available at https://github.com/BheeshmSharma/SLaM-DiMM-MICCAI-BraTS-Challenge-2025.

We present a systematic investigation of Multi-modal Retrieval Augmented Multi-modal Generation (M^2RAG), a novel task that enables foundation models to process multi-modal web content and generate multi-modal responses, which exhibits better information density and readability. Despite its potential impact, M^2RAG remains understudied, lacking comprehensive analysis and high-quality data resources. To address this gap, we establish a comprehensive benchmark through a rigorous data curation pipeline, and employ text-modal metrics and multi-modal metrics based on foundation models for evaluation. We further propose several strategies for foundation models to process M^2RAG effectively and construct a training set by filtering high-quality samples using designed metrics. Our extensive experiments demonstrate the reliability of our proposed metrics, a landscape of model performance within our designed strategies, and show that our fine-tuned 7B-8B models outperform the state-of-the-art GPT-4o model. Additionally, we perform fine-grained analyses across diverse domains and validate the effectiveness of our designs in data curation pipeline. All resources, including codes, datasets, and model weights, will be publicly released.

Recent text and image foundation models are incredibly impressive, and these models are attracting an ever-increasing portion of research resources. In this position piece we aim to shift the ML research community's priorities ever so slightly to a different modality: tabular data. Tabular data is the dominant modality in many fields, yet it is given hardly any research attention and significantly lags behind in terms of scale and power. We believe the time is now to start developing tabular foundation models, or what we coin a Large Tabular Model (LTM). LTMs could revolutionise the way science and ML use tabular data: not as single datasets that are analyzed in a vacuum, but contextualized with respect to related datasets. The potential impact is far-reaching: from few-shot tabular models to automating data science; from out-of-distribution synthetic data to empowering multidisciplinary scientific discovery. We intend to excite reflections on the modalities we study, and convince some researchers to study large tabular models.

The field of Earth Observations (EO) offers a wealth of data from diverse sensors, presenting a great opportunity for advancing self-supervised multimodal learning. However, current multimodal EO datasets and models focus on a single data type, either mono-date images or time series, which limits their expressivity. We introduce OmniSat, a novel architecture that exploits the spatial alignment between multiple EO modalities to learn expressive multimodal representations without labels. To demonstrate the advantages of combining modalities of different natures, we augment two existing datasets with new modalities. As demonstrated on three downstream tasks: forestry, land cover classification, and crop mapping. OmniSat can learn rich representations in an unsupervised manner, leading to improved performance in the semi- and fully-supervised settings, even when only one modality is available for inference. The code and dataset are available at github.com/gastruc/OmniSat.

Learning from multiple modalities, such as audio and video, offers opportunities for leveraging complementary information, enhancing robustness, and improving contextual understanding and performance. However, combining such modalities presents challenges, especially when modalities differ in data structure, predictive contribution, and the complexity of their learning processes. It has been observed that one modality can potentially dominate the learning process, hindering the effective utilization of information from other modalities and leading to sub-optimal model performance. To address this issue the vast majority of previous works suggest to assess the unimodal contributions and dynamically adjust the training to equalize them. We improve upon previous work by introducing a multi-loss objective and further refining the balancing process, allowing it to dynamically adjust the learning pace of each modality in both directions, acceleration and deceleration, with the ability to phase out balancing effects upon convergence. We achieve superior results across three audio-video datasets: on CREMA-D, models with ResNet backbone encoders surpass the previous best by 1.9% to 12.4%, and Conformer backbone models deliver improvements ranging from 2.8% to 14.1% across different fusion methods. On AVE, improvements range from 2.7% to 7.7%, while on UCF101, gains reach up to 6.1%.

Online video web content is richly multimodal: a single video blends vision, speech, ambient audio, and on-screen text. Retrieval systems typically treat these modalities as independent retrieval sources, which can lead to noisy and subpar retrieval. We explore multimodal video content retrieval, where relevance can be scored from one particular modality or jointly across multiple modalities simultaneously. Consequently, an effective retriever must dynamically choose which modality (or set of modalities) best addresses the query. We introduce CLaMR, a multimodal, late-interaction retriever that jointly indexes 4 modalities: video frames, transcribed speech, on-screen text, and metadata. CLaMR jointly encodes all modalities with a unified multimodal backbone for improved contextualization and is trained to enhance dynamic modality selection via two key innovations. First, given the lack of training data for multimodal retrieval, we introduce MultiVENT 2.0++, a large-scale synthetic training dataset built on MultiVENT 2.0 (event-centric videos in various languages paired with queries) with modality-targeted queries. Next, we propose a modality-aware loss that jointly trains according to a standard contrastive objective alongside an objective for learning correct modality usage. On the test sets of MultiVENT 2.0++ and MSRVTT, conventional aggregation strategies, such as averaging similarities for baseline retrievers, degrade performance by introducing noise from irrelevant modalities. In contrast, CLaMR consistently outperforms existing retrievers: on MultiVENT 2.0++, CLaMR improves nDCG@10 by 25.6 over the best single-modality retriever and by 35.4 over the best multi-modality retriever. We illustrate CLaMR's downstream utility on long-video QA, retrieving relevant frames and obtaining a 3.50% boost over LanguageBind on Video-MME and 1.42% over dense sampling on LongVideoBench.

The advances in remote sensing technologies have boosted applications for Earth observation. These technologies provide multiple observations or views with different levels of information. They might contain static or temporary views with different levels of resolution, in addition to having different types and amounts of noise due to sensor calibration or deterioration. A great variety of deep learning models have been applied to fuse the information from these multiple views, known as deep multi-view or multi-modal fusion learning. However, the approaches in the literature vary greatly since different terminology is used to refer to similar concepts or different illustrations are given to similar techniques. This article gathers works on multi-view fusion for Earth observation by focusing on the common practices and approaches used in the literature. We summarize and structure insights from several different publications concentrating on unifying points and ideas. In this manuscript, we provide a harmonized terminology while at the same time mentioning the various alternative terms that are used in literature. The topics covered by the works reviewed focus on supervised learning with the use of neural network models. We hope this review, with a long list of recent references, can support future research and lead to a unified advance in the area.

Financial organizations collect a huge amount of data about clients that typically has a temporal (sequential) structure and is collected from various sources (modalities). Due to privacy issues, there are no large-scale open-source multimodal datasets of event sequences, which significantly limits the research in this area. In this paper, we present the industrial-scale publicly available multimodal banking dataset, MBD, that contains more than 1.5M corporate clients with several modalities: 950M bank transactions, 1B geo position events, 5M embeddings of dialogues with technical support and monthly aggregated purchases of four bank's products. All entries are properly anonymized from real proprietary bank data. Using this dataset, we introduce a novel benchmark with two business tasks: campaigning (purchase prediction in the next month) and matching of clients. We provide numerical results that demonstrate the superiority of our multi-modal baselines over single-modal techniques for each task. As a result, the proposed dataset can open new perspectives and facilitate the future development of practically important large-scale multimodal algorithms for event sequences. HuggingFace Link: https://huggingface.co/datasets/ai-lab/MBD Github Link: https://github.com/Dzhambo/MBD

In real-world scenarios, using multiple modalities like visible (RGB) and infrared (IR) can greatly improve the performance of a predictive task such as object detection (OD). Multimodal learning is a common way to leverage these modalities, where multiple modality-specific encoders and a fusion module are used to improve performance. In this paper, we tackle a different way to employ RGB and IR modalities, where only one modality or the other is observed by a single shared vision encoder. This realistic setting requires a lower memory footprint and is more suitable for applications such as autonomous driving and surveillance, which commonly rely on RGB and IR data. However, when learning a single encoder on multiple modalities, one modality can dominate the other, producing uneven recognition results. This work investigates how to efficiently leverage RGB and IR modalities to train a common transformer-based OD vision encoder, while countering the effects of modality imbalance. For this, we introduce a novel training technique to Mix Patches (MiPa) from the two modalities, in conjunction with a patch-wise modality agnostic module, for learning a common representation of both modalities. Our experiments show that MiPa can learn a representation to reach competitive results on traditional RGB/IR benchmarks while only requiring a single modality during inference. Our code is available at: https://github.com/heitorrapela/MiPa.

Accurate and interpretable multi-disease diagnosis remains a critical challenge in medical research, particularly when leveraging heterogeneous multimodal medical data. Current approaches often rely on single-modal data, limiting their ability to comprehensively understand complex diseases. To address this, we propose MedTVT-R1, a novel Multimodal Large Language Model (MLLM) framework designed to integrate clinical multimodal data for reasoning and diagnosing multiple diseases. We construct MedTVT-QA, a curated instruction dataset that provides question-answer pairs for physiological-level interpretations and disease-level diagnoses with a Chain of Evidence approach. MedTVT-R1 incorporates a modality perception layer to capture inter-modal dependencies and adaptively weight modality contributions. Additionally, we employ Group Relative Policy Optimization (GRPO)-based Reinforcement Fine-Tuning with a Jaccard Reward function to enhance diagnostic reasoning. Experimental results demonstrate MedTVT-R1's superiority in multimodal feature utilization and multi-disease diagnosis, offering significant potential for clinical applications such as diagnostic report generation and comorbidity reasoning. The dataset and code are available at https://github.com/keke-nice/MedTVT-R1.

Accurate medical classification requires a large number of multi-modal data, and in many cases, different feature types. Previous studies have shown promising results when using multi-modal data, outperforming single-modality models when classifying diseases such as Alzheimer's Disease (AD). However, those models are usually not flexible enough to handle missing modalities. Currently, the most common workaround is discarding samples with missing modalities which leads to considerable data under-utilization. Adding to the fact that labeled medical images are already scarce, the performance of data-driven methods like deep learning can be severely hampered. Therefore, a multi-modal method that can handle missing data in various clinical settings is highly desirable. In this paper, we present Multi-Modal Mixing Transformer (3MAT), a disease classification transformer that not only leverages multi-modal data but also handles missing data scenarios. In this work, we test 3MT for AD and Cognitively normal (CN) classification and mild cognitive impairment (MCI) conversion prediction to progressive MCI (pMCI) or stable MCI (sMCI) using clinical and neuroimaging data. The model uses a novel Cascaded Modality Transformer architecture with cross-attention to incorporate multi-modal information for more informed predictions. We propose a novel modality dropout mechanism to ensure an unprecedented level of modality independence and robustness to handle missing data scenarios. The result is a versatile network that enables the mixing of arbitrary numbers of modalities with different feature types and also ensures full data utilization missing data scenarios. The model is trained and evaluated on the ADNI dataset with the SOTRA performance and further evaluated with the AIBL dataset with missing data.

Scene understanding using multi-modal data is necessary in many applications, e.g., autonomous navigation. To achieve this in a variety of situations, existing models must be able to adapt to shifting data distributions without arduous data annotation. Current approaches assume that the source data is available during adaptation and that the source consists of paired multi-modal data. Both these assumptions may be problematic for many applications. Source data may not be available due to privacy, security, or economic concerns. Assuming the existence of paired multi-modal data for training also entails significant data collection costs and fails to take advantage of widely available freely distributed pre-trained uni-modal models. In this work, we relax both of these assumptions by addressing the problem of adapting a set of models trained independently on uni-modal data to a target domain consisting of unlabeled multi-modal data, without having access to the original source dataset. Our proposed approach solves this problem through a switching framework which automatically chooses between two complementary methods of cross-modal pseudo-label fusion -- agreement filtering and entropy weighting -- based on the estimated domain gap. We demonstrate our work on the semantic segmentation problem. Experiments across seven challenging adaptation scenarios verify the efficacy of our approach, achieving results comparable to, and in some cases outperforming, methods which assume access to source data. Our method achieves an improvement in mIoU of up to 12% over competing baselines. Our code is publicly available at https://github.com/csimo005/SUMMIT.

Multimodal foundation models that can holistically process text alongside images, video, audio, and other sensory modalities are increasingly used in a variety of real-world applications. However, it is challenging to characterize and study progress in multimodal foundation models, given the range of possible modeling decisions, tasks, and domains. In this paper, we introduce Holistic Evaluation of Multimodal Models (HEMM) to systematically evaluate the capabilities of multimodal foundation models across a set of 3 dimensions: basic skills, information flow, and real-world use cases. Basic multimodal skills are internal abilities required to solve problems, such as learning interactions across modalities, fine-grained alignment, multi-step reasoning, and the ability to handle external knowledge. Information flow studies how multimodal content changes during a task through querying, translation, editing, and fusion. Use cases span domain-specific challenges introduced in real-world multimedia, affective computing, natural sciences, healthcare, and human-computer interaction applications. Through comprehensive experiments across the 30 tasks in HEMM, we (1) identify key dataset dimensions (e.g., basic skills, information flows, and use cases) that pose challenges to today's models, and (2) distill performance trends regarding how different modeling dimensions (e.g., scale, pre-training data, multimodal alignment, pre-training, and instruction tuning objectives) influence performance. Our conclusions regarding challenging multimodal interactions, use cases, and tasks requiring reasoning and external knowledge, the benefits of data and model scale, and the impacts of instruction tuning yield actionable insights for future work in multimodal foundation models.

Information Retrieval (IR) methods aim to identify relevant documents in response to a given query, which have gained remarkable attention due to their successful application in various natural language tasks. However, existing approaches typically consider only the textual information within the documents, which overlooks the fact that documents can contain multiple modalities, including texts, images, and tables. Further, they often segment each long document into multiple discrete passages for embedding, preventing them from capturing the overall document context and interactions between paragraphs. We argue that these two limitations lead to suboptimal document representations for retrieval. In this work, to address them, we aim to produce more comprehensive and nuanced document representations by holistically embedding documents interleaved with different modalities. Specifically, we achieve this by leveraging the capability of recent vision-language models that enable the processing and integration of text, images, and tables into a unified format and representation. Moreover, to mitigate the information loss from segmenting documents into passages, instead of representing and retrieving passages individually, we further merge the representations of segmented passages into one single document representation, while we additionally introduce a reranking strategy to decouple and identify the relevant passage within the document if necessary. Then, through extensive experiments on diverse information retrieval scenarios considering both the textual and multimodal queries, we show that our approach substantially outperforms relevant baselines, thanks to the consideration of the multimodal information interleaved within the documents in a unified way.

Multi-modal co-learning is emerging as an effective paradigm in machine learning, enabling models to collaboratively learn from different modalities to enhance single-modality predictions. Earth Observation (EO) represents a quintessential domain for multi-modal data analysis, wherein diverse remote sensors collect data to sense our planet. This unprecedented volume of data introduces novel challenges. Specifically, the access to the same sensor modalities at both training and inference stages becomes increasingly complex based on real-world constraints affecting remote sensing platforms. In this context, multi-modal co-learning presents a promising strategy to leverage the vast amount of sensor-derived data available at the training stage to improve single-modality models for inference-time deployment. Most current research efforts focus on designing customized solutions for either particular downstream tasks or specific modalities available at the inference stage. To address this, we propose a novel multi-modal co-learning framework capable of generalizing across various tasks without targeting a specific modality for inference. Our approach combines contrastive and modality discriminative learning together to guide single-modality models to structure the internal model manifold into modality-shared and modality-specific information. We evaluate our framework on four EO benchmarks spanning classification and regression tasks across different sensor modalities, where only one of the modalities available during training is accessible at inference time. Our results demonstrate consistent predictive improvements over state-of-the-art approaches from the recent machine learning and computer vision literature, as well as EO-specific methods. The obtained findings validate our framework in the single-modality inference scenarios across a diverse range of EO applications.

One important challenge of applying deep learning to electronic health records (EHR) is the complexity of their multimodal structure. EHR usually contains a mixture of structured (codes) and unstructured (free-text) data with sparse and irregular longitudinal features -- all of which doctors utilize when making decisions. In the deep learning regime, determining how different modality representations should be fused together is a difficult problem, which is often addressed by handcrafted modeling and intuition. In this work, we extend state-of-the-art neural architecture search (NAS) methods and propose MUltimodal Fusion Architecture SeArch (MUFASA) to simultaneously search across multimodal fusion strategies and modality-specific architectures for the first time. We demonstrate empirically that our MUFASA method outperforms established unimodal NAS on public EHR data with comparable computation costs. In addition, MUFASA produces architectures that outperform Transformer and Evolved Transformer. Compared with these baselines on CCS diagnosis code prediction, our discovered models improve top-5 recall from 0.88 to 0.91 and demonstrate the ability to generalize to other EHR tasks. Studying our top architecture in depth, we provide empirical evidence that MUFASA's improvements are derived from its ability to both customize modeling for each data modality and find effective fusion strategies.

Conventional multimodal recommender systems predominantly leverage Bayesian Personalized Ranking (BPR) optimization to learn item representations by amalgamating item identity (ID) embeddings with multimodal features. Nevertheless, our empirical and theoretical findings unequivocally demonstrate a pronounced optimization gradient bias in favor of acquiring representations from multimodal features over item ID embeddings. As a consequence, item ID embeddings frequently exhibit suboptimal characteristics despite the convergence of multimodal feature parameters. Given the rich informational content inherent in multimodal features, in this paper, we propose a novel model (i.e., LIRDRec) that learns item representations directly from these features to augment recommendation performance. Recognizing that features derived from each modality may capture disparate yet correlated aspects of items, we propose a multimodal transformation mechanism, integrated with modality-specific encoders, to effectively fuse features from all modalities. Moreover, to differentiate the influence of diverse modality types, we devise a progressive weight copying fusion module within LIRDRec. This module incrementally learns the weight assigned to each modality in synthesizing the final user or item representations. Finally, we utilize the powerful visual understanding of Multimodal Large Language Models (MLLMs) to convert the item images into texts and extract semantics embeddings upon the texts via LLMs. Empirical evaluations conducted on five real-world datasets validate the superiority of our approach relative to competing baselines. It is worth noting the proposed model, equipped with embeddings extracted from MLLMs and LLMs, can further improve the recommendation accuracy of NDCG@20 by an average of 4.21% compared to the original embeddings.

Multimodal magnetic resonance imaging (MRI) constitutes the first line of investigation for clinicians in the care of brain tumors, providing crucial insights for surgery planning, treatment monitoring, and biomarker identification. Pre-training on large datasets have been shown to help models learn transferable representations and adapt with minimal labeled data. This behavior is especially valuable in medical imaging, where annotations are often scarce. However, applying this paradigm to multimodal medical data introduces a challenge: most existing approaches assume that all imaging modalities are available during both pre-training and fine-tuning. In practice, missing modalities often occur due to acquisition issues, specialist unavailability, or specific experimental designs on small in-house datasets. Consequently, a common approach involves training a separate model for each desired modality combination, making the process both resource-intensive and impractical for clinical use. Therefore, we introduce BM-MAE, a masked image modeling pre-training strategy tailored for multimodal MRI data. The same pre-trained model seamlessly adapts to any combination of available modalities, extracting rich representations that capture both intra- and inter-modal information. This allows fine-tuning on any subset of modalities without requiring architectural changes, while still benefiting from a model pre-trained on the full set of modalities. Extensive experiments show that the proposed pre-training strategy outperforms or remains competitive with baselines that require separate pre-training for each modality subset, while substantially surpassing training from scratch on several downstream tasks. Additionally, it can quickly and efficiently reconstruct missing modalities, highlighting its practical value. Code and trained models are available at: https://github.com/Lucas-rbnt/BM-MAE

Multimodal recommendation systems have attracted increasing attention for their improved performance by leveraging items' multimodal information. Prior methods often build modality-specific item-item semantic graphs from raw modality features and use them as supplementary structures alongside the user-item interaction graph to enhance user preference learning. However, these semantic graphs suffer from semantic deficiencies, including (1) insufficient modeling of collaborative signals among items and (2) structural distortions introduced by noise in raw modality features, ultimately compromising performance. To address these issues, we first extract collaborative signals from the interaction graph and infuse them into each modality-specific item semantic graph to enhance semantic modeling. Then, we design a modulus-based personalized embedding perturbation mechanism that injects perturbations with modulus-guided personalized intensity into embeddings to generate contrastive views. This enables the model to learn noise-robust representations through contrastive learning, thereby reducing the effect of structural noise in semantic graphs. Besides, we propose a dual representation alignment mechanism that first aligns multiple semantic representations via a designed Anchor-based InfoNCE loss using behavior representations as anchors, and then aligns behavior representations with the fused semantics by standard InfoNCE, to ensure representation consistency. Extensive experiments on four benchmark datasets validate the effectiveness of our framework.

Multimodal learning, a rapidly evolving field in artificial intelligence, seeks to construct more versatile and robust systems by integrating and analyzing diverse types of data, including text, images, audio, and video. Inspired by the human ability to assimilate information through many senses, this method enables applications such as text-to-video conversion, visual question answering, and image captioning. Recent developments in datasets that support multimodal language models (MLLMs) are highlighted in this overview. Large-scale multimodal datasets are essential because they allow for thorough testing and training of these models. With an emphasis on their contributions to the discipline, the study examines a variety of datasets, including those for training, domain-specific tasks, and real-world applications. It also emphasizes how crucial benchmark datasets are for assessing models' performance in a range of scenarios, scalability, and applicability. Since multimodal learning is always changing, overcoming these obstacles will help AI research and applications reach new heights.

We introduce OmnixR, an evaluation suite designed to benchmark SoTA Omni-modality Language Models, such as GPT-4o and Gemini. Evaluating OLMs, which integrate multiple modalities such as text, vision, and audio, presents unique challenges. Particularly, the user message might often consist of multiple modalities, such that OLMs have to establish holistic understanding and reasoning across modalities to accomplish the task. Existing benchmarks are limited to single modality or dual-modality tasks, overlooking comprehensive multi-modal assessments of model reasoning. To address this, OmnixR offers two evaluation variants: (1)synthetic subset: a synthetic dataset generated automatically by translating text into multiple modalities--audio, images, video, and hybrids (Omnify). (2)realistic subset: a real-world dataset, manually curated and annotated by experts, for evaluating cross-modal reasoning in natural settings. OmnixR presents a unique evaluation towards assessing OLMs over a diverse mix of modalities, such as a question that involves video, audio, and text, providing a rigorous cross-modal reasoning testbed unlike any existing benchmarks. Our experiments find that all state-of-the-art OLMs struggle with OmnixR questions that require integrating information from multiple modalities to answer. Further analysis highlights differences in reasoning behavior, underscoring the challenges of omni-modal AI alignment.

As information exists in various modalities in real world, effective interaction and fusion among multimodal information plays a key role for the creation and perception of multimodal data in computer vision and deep learning research. With superb power in modeling the interaction among multimodal information, multimodal image synthesis and editing has become a hot research topic in recent years. Instead of providing explicit guidance for network training, multimodal guidance offers intuitive and flexible means for image synthesis and editing. On the other hand, this field is also facing several challenges in alignment of multimodal features, synthesis of high-resolution images, faithful evaluation metrics, etc. In this survey, we comprehensively contextualize the advance of the recent multimodal image synthesis and editing and formulate taxonomies according to data modalities and model types. We start with an introduction to different guidance modalities in image synthesis and editing, and then describe multimodal image synthesis and editing approaches extensively according to their model types. After that, we describe benchmark datasets and evaluation metrics as well as corresponding experimental results. Finally, we provide insights about the current research challenges and possible directions for future research. A project associated with this survey is available at https://github.com/fnzhan/Generative-AI.

In the diverse field of medical imaging, automatic segmentation has numerous applications and must handle a wide variety of input domains, such as different types of Computed Tomography (CT) scans and Magnetic Resonance (MR) images. This heterogeneity challenges automatic segmentation algorithms to maintain consistent performance across different modalities due to the requirement for spatially aligned and paired images. Typically, segmentation models are trained using a single modality, which limits their ability to generalize to other types of input data without employing transfer learning techniques. Additionally, leveraging complementary information from different modalities to enhance segmentation precision often necessitates substantial modifications to popular encoder-decoder designs, such as introducing multiple branched encoding or decoding paths for each modality. In this work, we propose a simple Multi-Modal Segmentation (MulModSeg) strategy to enhance medical image segmentation across multiple modalities, specifically CT and MR. It incorporates two key designs: a modality-conditioned text embedding framework via a frozen text encoder that adds modality awareness to existing segmentation frameworks without significant structural modifications or computational overhead, and an alternating training procedure that facilitates the integration of essential features from unpaired CT and MR inputs. Through extensive experiments with both Fully Convolutional Network and Transformer-based backbones, MulModSeg consistently outperforms previous methods in segmenting abdominal multi-organ and cardiac substructures for both CT and MR modalities. The code is available in this {https://github.com/ChengyinLee/MulModSeg_2024{link}}.

In many scientific fields, large language models (LLMs) have revolutionized the way text and other modalities of data (e.g., molecules and proteins) are handled, achieving superior performance in various applications and augmenting the scientific discovery process. Nevertheless, previous surveys on scientific LLMs often concentrate on one or two fields or a single modality. In this paper, we aim to provide a more holistic view of the research landscape by unveiling cross-field and cross-modal connections between scientific LLMs regarding their architectures and pre-training techniques. To this end, we comprehensively survey over 260 scientific LLMs, discuss their commonalities and differences, as well as summarize pre-training datasets and evaluation tasks for each field and modality. Moreover, we investigate how LLMs have been deployed to benefit scientific discovery. Resources related to this survey are available at https://github.com/yuzhimanhua/Awesome-Scientific-Language-Models.

Current multimodal and multitask foundation models like 4M or UnifiedIO show promising results, but in practice their out-of-the-box abilities to accept diverse inputs and perform diverse tasks are limited by the (usually rather small) number of modalities and tasks they are trained on. In this paper, we expand upon the capabilities of them by training a single model on tens of highly diverse modalities and by performing co-training on large-scale multimodal datasets and text corpora. This includes training on several semantic and geometric modalities, feature maps from recent state of the art models like DINOv2 and ImageBind, pseudo labels of specialist models like SAM and 4DHumans, and a range of new modalities that allow for novel ways to interact with the model and steer the generation, for example image metadata or color palettes. A crucial step in this process is performing discrete tokenization on various modalities, whether they are image-like, neural network feature maps, vectors, structured data like instance segmentation or human poses, or data that can be represented as text. Through this, we expand on the out-of-the-box capabilities of multimodal models and specifically show the possibility of training one model to solve at least 3x more tasks/modalities than existing ones and doing so without a loss in performance. This enables more fine-grained and controllable multimodal generation capabilities and allows us to study the distillation of models trained on diverse data and objectives into a unified model. We successfully scale the training to a three billion parameter model using tens of modalities and different datasets. The resulting models and training code are open sourced at 4m.epfl.ch.

Medical decision-making requires integrating diverse medical information, from imaging to clinical narratives. These medical modalities are often acquired in a many-to-many manner. However, current medical vision-language pretraining models (Med-VLPMs) fail to directly account for this many-to-many mapping in their model training and embeddings. To address this, we present Probabilistic Modality-Enhanced Diagnosis (ProbMED), a multimodal Med-VLPM that employs probabilistic contrastive learning to model distributions over embeddings rather than deterministic estimates. ProbMED aligns four distinct modalities -- chest X-rays, electrocardiograms, echocardiograms, and clinical text -- into a unified probabilistic embedding space. We use InfoNCE loss with Hellinger distance to integrate inter-modality distributions. We introduce a probabilistic synthetic sampling loss that captures modality-specific mean and variance to improve intra-modality binding. Extensive experiments across 13 medical datasets demonstrate that our model outperforms current Med-VLPMs in cross-modality retrieval, zero-shot, and few-shot classification. We also demonstrate the robust integration of multiple modalities for prognostication, showing improved intra- and inter-medical modality binding.

The multifaceted nature of human perception and comprehension indicates that, when we think, our body can naturally take any combination of senses, a.k.a., modalities and form a beautiful picture in our brain. For example, when we see a cattery and simultaneously perceive the cat's purring sound, our brain can construct a picture of a cat in the cattery. Intuitively, generative AI models should hold the versatility of humans and be capable of generating images from any combination of modalities efficiently and collaboratively. This paper presents ImgAny, a novel end-to-end multi-modal generative model that can mimic human reasoning and generate high-quality images. Our method serves as the first attempt in its capacity of efficiently and flexibly taking any combination of seven modalities, ranging from language, audio to vision modalities, including image, point cloud, thermal, depth, and event data. Our key idea is inspired by human-level cognitive processes and involves the integration and harmonization of multiple input modalities at both the entity and attribute levels without specific tuning across modalities. Accordingly, our method brings two novel training-free technical branches: 1) Entity Fusion Branch ensures the coherence between inputs and outputs. It extracts entity features from the multi-modal representations powered by our specially constructed entity knowledge graph; 2) Attribute Fusion Branch adeptly preserves and processes the attributes. It efficiently amalgamates distinct attributes from diverse input modalities via our proposed attribute knowledge graph. Lastly, the entity and attribute features are adaptively fused as the conditional inputs to the pre-trained Stable Diffusion model for image generation. Extensive experiments under diverse modality combinations demonstrate its exceptional capability for visual content creation.

Leveraging information across diverse modalities is known to enhance performance on multimodal segmentation tasks. However, effectively fusing information from different modalities remains challenging due to the unique characteristics of each modality. In this paper, we propose a novel fusion strategy that can effectively fuse information from different modality combinations. We also propose a new model named Multi-Modal Segmentation TransFormer (MMSFormer) that incorporates the proposed fusion strategy to perform multimodal material and semantic segmentation tasks. MMSFormer outperforms current state-of-the-art models on three different datasets. As we begin with only one input modality, performance improves progressively as additional modalities are incorporated, showcasing the effectiveness of the fusion block in combining useful information from diverse input modalities. Ablation studies show that different modules in the fusion block are crucial for overall model performance. Furthermore, our ablation studies also highlight the capacity of different input modalities to improve performance in the identification of different types of materials. The code and pretrained models will be made available at https://github.com/csiplab/MMSFormer.

Recent advancements in multimodal large language models (MLLMs) have aimed to integrate and interpret data across diverse modalities. However, the capacity of these models to concurrently process and reason about multiple modalities remains inadequately explored, partly due to the lack of comprehensive modality-wise benchmarks. We introduce OmniBench, a novel benchmark designed to rigorously evaluate models' ability to recognize, interpret, and reason across visual, acoustic, and textual inputs simultaneously. We define models capable of such tri-modal processing as omni-language models (OLMs). OmniBench is distinguished by high-quality human annotations, ensuring that accurate responses require integrated understanding and reasoning across all three modalities. Our main findings reveal that: i) open-source OLMs exhibit critical limitations in instruction-following and reasoning capabilities within tri-modal contexts; and ii) the baseline models perform poorly (below 50% accuracy) even when provided with alternative textual representations of images and audio. These results suggest that the ability to construct a consistent context from text, image, and audio is often overlooked in existing MLLM training paradigms. We advocate for future research to focus on developing more robust tri-modal integration techniques and training strategies to enhance OLM performance across diverse modalities. The codes and live leaderboard could be found at https://m-a-p.ai/OmniBench.

Medical vision-and-language pre-training (Med-VLP) has shown promising improvements on many downstream medical tasks owing to its applicability to extracting generic representations from medical images and texts. Practically, there exist two typical types, i.e., the fusion-encoder type and the dual-encoder type, depending on whether a heavy fusion module is used. The former is superior at multi-modal tasks owing to the sufficient interaction between modalities; the latter is good at uni-modal and cross-modal tasks due to the single-modality encoding ability. To take advantage of these two types, we propose an effective yet straightforward scheme named PTUnifier to unify the two types. We first unify the input format by introducing visual and textual prompts, which serve as a feature bank that stores the most representative images/texts. By doing so, a single model could serve as a foundation model that processes various tasks adopting different input formats (i.e., image-only, text-only, and image-text-pair). Furthermore, we construct a prompt pool (instead of static ones) to improve diversity and scalability. Experimental results show that our approach achieves state-of-the-art results on a broad range of tasks, spanning uni-modal tasks (i.e., image/text classification and text summarization), cross-modal tasks (i.e., image-to-text generation and image-text/text-image retrieval), and multi-modal tasks (i.e., visual question answering), demonstrating the effectiveness of our approach. Note that the adoption of prompts is orthogonal to most existing Med-VLP approaches and could be a beneficial and complementary extension to these approaches.

Multimodal large language models (MLLMs) can simultaneously process visual, textual, and auditory data, capturing insights that complement human analysis. However, existing video question-answering (VidQA) benchmarks and datasets often exhibit a bias toward a single modality, despite the goal of requiring advanced reasoning skills that integrate diverse modalities to answer the queries. In this work, we introduce the modality importance score (MIS) to identify such bias. It is designed to assess which modality embeds the necessary information to answer the question. Additionally, we propose an innovative method using state-of-the-art MLLMs to estimate the modality importance, which can serve as a proxy for human judgments of modality perception. With this MIS, we demonstrate the presence of unimodal bias and the scarcity of genuinely multimodal questions in existing datasets. We further validate the modality importance score with multiple ablation studies to evaluate the performance of MLLMs on permuted feature sets. Our results indicate that current models do not effectively integrate information due to modality imbalance in existing datasets. Our proposed MLLM-derived MIS can guide the curation of modality-balanced datasets that advance multimodal learning and enhance MLLMs' capabilities to understand and utilize synergistic relations across modalities.

Recent advancements in Multimodal Large Language Models (MLLMs) underscore the significance of scalable models and data to boost performance, yet this often incurs substantial computational costs. Although the Mixture of Experts (MoE) architecture has been employed to efficiently scale large language and image-text models, these efforts typically involve fewer experts and limited modalities. To address this, our work presents the pioneering attempt to develop a unified MLLM with the MoE architecture, named Uni-MoE that can handle a wide array of modalities. Specifically, it features modality-specific encoders with connectors for a unified multimodal representation. We also implement a sparse MoE architecture within the LLMs to enable efficient training and inference through modality-level data parallelism and expert-level model parallelism. To enhance the multi-expert collaboration and generalization, we present a progressive training strategy: 1) Cross-modality alignment using various connectors with different cross-modality data, 2) Training modality-specific experts with cross-modality instruction data to activate experts' preferences, and 3) Tuning the Uni-MoE framework utilizing Low-Rank Adaptation (LoRA) on mixed multimodal instruction data. We evaluate the instruction-tuned Uni-MoE on a comprehensive set of multimodal datasets. The extensive experimental results demonstrate Uni-MoE's principal advantage of significantly reducing performance bias in handling mixed multimodal datasets, alongside improved multi-expert collaboration and generalization. Our findings highlight the substantial potential of MoE frameworks in advancing MLLMs and the code is available at https://github.com/HITsz-TMG/UMOE-Scaling-Unified-Multimodal-LLMs.

Multimodal learning is defined as learning over multiple heterogeneous input modalities such as video, audio, and text. In this work, we are concerned with understanding how models behave as the type of modalities differ between training and deployment, a situation that naturally arises in many applications of multimodal learning to hardware platforms. We present a multimodal robustness framework to provide a systematic analysis of common multimodal representation learning methods. Further, we identify robustness short-comings of these approaches and propose two intervention techniques leading to 1.5times-4times robustness improvements on three datasets, AudioSet, Kinetics-400 and ImageNet-Captions. Finally, we demonstrate that these interventions better utilize additional modalities, if present, to achieve competitive results of 44.2 mAP on AudioSet 20K.

Recent advances such as LLaVA and Mini-GPT4 have successfully integrated visual information into LLMs, yielding inspiring outcomes and giving rise to a new generation of multi-modal LLMs, or MLLMs. Nevertheless, these methods struggle with hallucinations and the mutual interference between tasks. To tackle these problems, we propose an efficient and accurate approach to adapt to downstream tasks by utilizing LLM as a bridge to connect multiple expert models, namely u-LLaVA. Firstly, we incorporate the modality alignment module and multi-task modules into LLM. Then, we reorganize or rebuild multi-type public datasets to enable efficient modality alignment and instruction following. Finally, task-specific information is extracted from the trained LLM and provided to different modules for solving downstream tasks. The overall framework is simple, effective, and achieves state-of-the-art performance across multiple benchmarks. We also release our model, the generated data, and the code base publicly available.

Despite the recognized potential of multimodal data to improve model accuracy, many large-scale industrial recommendation systems, including Taobao display advertising system, predominantly depend on sparse ID features in their models. In this work, we explore approaches to leverage multimodal data to enhance the recommendation accuracy. We start from identifying the key challenges in adopting multimodal data in a manner that is both effective and cost-efficient for industrial systems. To address these challenges, we introduce a two-phase framework, including: 1) the pre-training of multimodal representations to capture semantic similarity, and 2) the integration of these representations with existing ID-based models. Furthermore, we detail the architecture of our production system, which is designed to facilitate the deployment of multimodal representations. Since the integration of multimodal representations in mid-2023, we have observed significant performance improvements in Taobao display advertising system. We believe that the insights we have gathered will serve as a valuable resource for practitioners seeking to leverage multimodal data in their systems.

Traditional multimodal learners find unified representations for tasks like visual question answering, but rely heavily on paired datasets. However, an overlooked yet potentially powerful question is: can one leverage auxiliary unpaired multimodal data to directly enhance representation learning in a target modality? We introduce UML: Unpaired Multimodal Learner, a modality-agnostic training paradigm in which a single model alternately processes inputs from different modalities while sharing parameters across them. This design exploits the assumption that different modalities are projections of a shared underlying reality, allowing the model to benefit from cross-modal structure without requiring explicit pairs. Theoretically, under linear data-generating assumptions, we show that unpaired auxiliary data can yield representations strictly more informative about the data-generating process than unimodal training. Empirically, we show that using unpaired data from auxiliary modalities -- such as text, audio, or images -- consistently improves downstream performance across diverse unimodal targets such as image and audio. Our project page: https://unpaired-multimodal.github.io/

Recently, the astonishing performance of large language models (LLMs) in natural language comprehension and generation tasks triggered lots of exploration of using them as central controllers to build agent systems. Multiple studies focus on bridging the LLMs to external tools to extend the application scenarios. However, the current LLMs' perceiving tool-use ability is limited to a single text query, which may result in ambiguity in understanding the users' real intentions. LLMs are expected to eliminate that by perceiving the visual- or auditory-grounded instructions' information. Therefore, in this paper, we propose MLLM-Tool, a system incorporating open-source LLMs and multi-modal encoders so that the learnt LLMs can be conscious of multi-modal input instruction and then select the function-matched tool correctly. To facilitate the evaluation of the model's capability, we collect a dataset featured by consisting of multi-modal input tools from HuggingFace. Another important feature of our dataset is that our dataset also contains multiple potential choices for the same instruction due to the existence of identical functions and synonymous functions, which provides more potential solutions for the same query. The experiments reveal that our MLLM-Tool is capable of recommending appropriate tools for multi-modal instructions. Codes and data are available at https://github.com/MLLM-Tool/MLLM-Tool.

Information retrieval is an ever-evolving and crucial research domain. The substantial demand for high-quality human motion data especially in online acquirement has led to a surge in human motion research works. Prior works have mainly concentrated on dual-modality learning, such as text and motion tasks, but three-modality learning has been rarely explored. Intuitively, an extra introduced modality can enrich a model's application scenario, and more importantly, an adequate choice of the extra modality can also act as an intermediary and enhance the alignment between the other two disparate modalities. In this work, we introduce LAVIMO (LAnguage-VIdeo-MOtion alignment), a novel framework for three-modality learning integrating human-centric videos as an additional modality, thereby effectively bridging the gap between text and motion. Moreover, our approach leverages a specially designed attention mechanism to foster enhanced alignment and synergistic effects among text, video, and motion modalities. Empirically, our results on the HumanML3D and KIT-ML datasets show that LAVIMO achieves state-of-the-art performance in various motion-related cross-modal retrieval tasks, including text-to-motion, motion-to-text, video-to-motion and motion-to-video.

In this work, we introduce Multiple Embedding Model for EHR (MEME), an approach that views Electronic Health Records (EHR) as multimodal data. This approach incorporates "pseudo-notes", textual representations of tabular EHR concepts such as diagnoses and medications, and allows us to effectively employ Large Language Models (LLMs) for EHR representation. This framework also adopts a multimodal approach, embedding each EHR modality separately. We demonstrate the effectiveness of MEME by applying it to several tasks within the Emergency Department across multiple hospital systems. Our findings show that MEME surpasses the performance of both single modality embedding methods and traditional machine learning approaches. However, we also observe notable limitations in generalizability across hospital institutions for all tested models.

People perceive the world with multiple senses (e.g., through hearing sounds, reading words and seeing objects). However, most existing AI systems only process an individual modality. This paper presents an approach that excels at handling multiple modalities of information with a single model. In our "{SkillNet}" model, different parts of the parameters are specialized for processing different modalities. Unlike traditional dense models that always activate all the model parameters, our model sparsely activates parts of the parameters whose skills are relevant to the task. Such model design enables SkillNet to learn skills in a more interpretable way. We develop our model for five modalities including text, image, sound, video and code. Results show that, SkillNet performs comparably to five modality-specific fine-tuned models. Moreover, our model supports self-supervised pretraining with the same sparsely activated way, resulting in better initialized parameters for different modalities. We find that pretraining significantly improves the performance of SkillNet on five modalities, on par with or even better than baselines with modality-specific pretraining. On the task of Chinese text-to-image retrieval, our final system achieves higher accuracy than existing leading systems including Wukong{ViT-B} and Wenlan 2.0 while using less number of activated parameters.

This paper presents OmniDataComposer, an innovative approach for multimodal data fusion and unlimited data generation with an intent to refine and uncomplicate interplay among diverse data modalities. Coming to the core breakthrough, it introduces a cohesive data structure proficient in processing and merging multimodal data inputs, which include video, audio, and text. Our crafted algorithm leverages advancements across multiple operations such as video/image caption extraction, dense caption extraction, Automatic Speech Recognition (ASR), Optical Character Recognition (OCR), Recognize Anything Model(RAM), and object tracking. OmniDataComposer is capable of identifying over 6400 categories of objects, substantially broadening the spectrum of visual information. It amalgamates these diverse modalities, promoting reciprocal enhancement among modalities and facilitating cross-modal data correction. The final output metamorphoses each video input into an elaborate sequential document, virtually transmuting videos into thorough narratives, making them easier to be processed by large language models. Future prospects include optimizing datasets for each modality to encourage unlimited data generation. This robust base will offer priceless insights to models like ChatGPT, enabling them to create higher quality datasets for video captioning and easing question-answering tasks based on video content. OmniDataComposer inaugurates a new stage in multimodal learning, imparting enormous potential for augmenting AI's understanding and generation of complex, real-world data.

Recent advances in learning multi-modal representation have witnessed the success in biomedical domains. While established techniques enable handling multi-modal information, the challenges are posed when extended to various clinical modalities and practical modalitymissing setting due to the inherent modality gaps. To tackle these, we propose an innovative Modality-prompted Heterogeneous Graph for Omnimodal Learning (GTP-4o), which embeds the numerous disparate clinical modalities into a unified representation, completes the deficient embedding of missing modality and reformulates the cross-modal learning with a graph-based aggregation. Specially, we establish a heterogeneous graph embedding to explicitly capture the diverse semantic properties on both the modality-specific features (nodes) and the cross-modal relations (edges). Then, we design a modality-prompted completion that enables completing the inadequate graph representation of missing modality through a graph prompting mechanism, which generates hallucination graphic topologies to steer the missing embedding towards the intact representation. Through the completed graph, we meticulously develop a knowledge-guided hierarchical cross-modal aggregation consisting of a global meta-path neighbouring to uncover the potential heterogeneous neighbors along the pathways driven by domain knowledge, and a local multi-relation aggregation module for the comprehensive cross-modal interaction across various heterogeneous relations. We assess the efficacy of our methodology on rigorous benchmarking experiments against prior state-of-the-arts. In a nutshell, GTP-4o presents an initial foray into the intriguing realm of embedding, relating and perceiving the heterogeneous patterns from various clinical modalities holistically via a graph theory. Project page: https://gtp-4-o.github.io/.

Visible-infrared person re-identification (VIReID) primarily deals with matching identities across person images from different modalities. Due to the modality gap between visible and infrared images, cross-modality identity matching poses significant challenges. Recognizing that high-level semantics of pedestrian appearance, such as gender, shape, and clothing style, remain consistent across modalities, this paper intends to bridge the modality gap by infusing visual features with high-level semantics. Given the capability of CLIP to sense high-level semantic information corresponding to visual representations, we explore the application of CLIP within the domain of VIReID. Consequently, we propose a CLIP-Driven Semantic Discovery Network (CSDN) that consists of Modality-specific Prompt Learner, Semantic Information Integration (SII), and High-level Semantic Embedding (HSE). Specifically, considering the diversity stemming from modality discrepancies in language descriptions, we devise bimodal learnable text tokens to capture modality-private semantic information for visible and infrared images, respectively. Additionally, acknowledging the complementary nature of semantic details across different modalities, we integrate text features from the bimodal language descriptions to achieve comprehensive semantics. Finally, we establish a connection between the integrated text features and the visual features across modalities. This process embed rich high-level semantic information into visual representations, thereby promoting the modality invariance of visual representations. The effectiveness and superiority of our proposed CSDN over existing methods have been substantiated through experimental evaluations on multiple widely used benchmarks. The code will be released at https://github.com/nengdong96/CSDN.

Multimodal learning has recently gained significant popularity, demonstrating impressive performance across various zero-shot classification tasks and a range of perceptive and generative applications. Models such as Contrastive Language-Image Pretraining (CLIP) are designed to bridge different modalities, such as images and text, by learning a shared representation space through contrastive learning. Despite their success, the working mechanisms underlying multimodal learning are not yet well understood. Notably, these models often exhibit a modality gap, where different modalities occupy distinct regions within the shared representation space. In this work, we conduct an in-depth analysis of the emergence of modality gap by characterizing the gradient flow learning dynamics. Specifically, we identify the critical roles of mismatched data pairs and a learnable temperature parameter in causing and perpetuating the modality gap during training. Furthermore, our theoretical insights are validated through experiments on practical CLIP models. These findings provide principled guidance for mitigating the modality gap, including strategies such as appropriate temperature scheduling and modality swapping. Additionally, we demonstrate that closing the modality gap leads to improved performance on tasks such as image-text retrieval.

Information retrieval is indispensable for today's Internet applications, yet traditional semantic matching techniques often fall short in capturing the fine-grained cross-modal interactions required for complex queries. Although late-fusion two-tower architectures attempt to bridge this gap by independently encoding visual and textual data before merging them at a high level, they frequently overlook the subtle interplay essential for comprehensive understanding. In this work, we rigorously assess these limitations and introduce a unified retrieval framework that fuses visual and textual cues from the ground up, enabling early cross-modal interactions for enhancing context interpretation. Through a two-stage training process--comprising post-training adaptation followed by instruction tuning--we adapt MLLMs as retrievers using a simple one-tower architecture. Our approach outperforms conventional methods across diverse retrieval scenarios, particularly when processing complex multi-modal inputs. Notably, the joint fusion encoder yields greater improvements on tasks that require modality fusion compared to those that do not, underscoring the transformative potential of early integration strategies and pointing toward a promising direction for contextually aware and effective information retrieval.

Multimodal learning significantly benefits cancer survival prediction, especially the integration of pathological images and genomic data. Despite advantages of multimodal learning for cancer survival prediction, massive redundancy in multimodal data prevents it from extracting discriminative and compact information: (1) An extensive amount of intra-modal task-unrelated information blurs discriminability, especially for gigapixel whole slide images (WSIs) with many patches in pathology and thousands of pathways in genomic data, leading to an ``intra-modal redundancy" issue. (2) Duplicated information among modalities dominates the representation of multimodal data, which makes modality-specific information prone to being ignored, resulting in an ``inter-modal redundancy" issue. To address these, we propose a new framework, Prototypical Information Bottlenecking and Disentangling (PIBD), consisting of Prototypical Information Bottleneck (PIB) module for intra-modal redundancy and Prototypical Information Disentanglement (PID) module for inter-modal redundancy. Specifically, a variant of information bottleneck, PIB, is proposed to model prototypes approximating a bunch of instances for different risk levels, which can be used for selection of discriminative instances within modality. PID module decouples entangled multimodal data into compact distinct components: modality-common and modality-specific knowledge, under the guidance of the joint prototypical distribution. Extensive experiments on five cancer benchmark datasets demonstrated our superiority over other methods.

Cancer has relational information residing at varying scales, modalities, and resolutions of the acquired data, such as radiology, pathology, genomics, proteomics, and clinical records. Integrating diverse data types can improve the accuracy and reliability of cancer diagnosis and treatment. There can be disease-related information that is too subtle for humans or existing technological tools to discern visually. Traditional methods typically focus on partial or unimodal information about biological systems at individual scales and fail to encapsulate the complete spectrum of the heterogeneous nature of data. Deep neural networks have facilitated the development of sophisticated multimodal data fusion approaches that can extract and integrate relevant information from multiple sources. Recent deep learning frameworks such as Graph Neural Networks (GNNs) and Transformers have shown remarkable success in multimodal learning. This review article provides an in-depth analysis of the state-of-the-art in GNNs and Transformers for multimodal data fusion in oncology settings, highlighting notable research studies and their findings. We also discuss the foundations of multimodal learning, inherent challenges, and opportunities for integrative learning in oncology. By examining the current state and potential future developments of multimodal data integration in oncology, we aim to demonstrate the promising role that multimodal neural networks can play in cancer prevention, early detection, and treatment through informed oncology practices in personalized settings.