Jaafer/graphUmls · Datasets at Hugging Face

CUI1 stringlengths 8 8	RELA stringlengths 3 54	CUI2 stringlengths 8 8	Name1 stringlengths 1 2.86k ⌀	Name2 stringlengths 1 2.86k ⌀	Def1 stringlengths 1 8.95k ⌀	Def2 stringlengths 1 8.95k ⌀
C0000039	mapped_to	C0043950	1,2-dipalmitoylphosphatidylcholine	1,3-dipalmitoyl-2-phosphatidylcholine	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	mapped_to	C0216971	1,2-dipalmitoylphosphatidylcholine	colfosceril palmitate	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	A lung surfactant agent that is used as a replacement for endogenous lung surfactant. Colfosceril palmitate is effective in reducing the surface tension of pulmonary fluids, thereby increasing lung compliance properties to prevent alveolar collapse and improve breathing. This drug is used in the treatment of neonatal respiratory distress.
C0000039	mapped_to	C0381030	1,2-dipalmitoylphosphatidylcholine	DEPN 8	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	mapped_to	C0615231	1,2-dipalmitoylphosphatidylcholine	1-palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	mapped_to	C0621533	1,2-dipalmitoylphosphatidylcholine	2-(3,6-bis(dimethylamino)-10-acridinyl)ethyl-(2,3-di-O-palmitoylglycero)phosphate	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	mapped_to	C1310941	1,2-dipalmitoylphosphatidylcholine	1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	mapped_to	C1611431	1,2-dipalmitoylphosphatidylcholine	palmitoyl-2-(N-4-nitrobenz-2-oxa-1,3-diazol)aminocaproyl-sn-glycero-3-phosphocholine	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	mapped_to	C3253442	1,2-dipalmitoylphosphatidylcholine	ETC 642	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	mapped_to	C3885037	1,2-dipalmitoylphosphatidylcholine	GLA-AF adjuvant	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	associated_with	C0523614	1,2-dipalmitoylphosphatidylcholine	Dipalmitoylphosphatidylcholine measurement	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	inverse_isa	C0031610	1,2-dipalmitoylphosphatidylcholine	Phosphatidic Acid	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	A glycerol backbone covalently bound to a phosphate group in one position, and fatty acids in the 2nd and 3rd positions. Phosphatidic acids thus have a polar head and apolar tails, and occur in cell membranes throughout nature.
C0000039	has_component	C0523614	1,2-dipalmitoylphosphatidylcholine	Dipalmitoylphosphatidylcholine measurement	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	has_measured_component	C0523614	1,2-dipalmitoylphosphatidylcholine	Dipalmitoylphosphatidylcholine measurement	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	same_as	C0216971	1,2-dipalmitoylphosphatidylcholine	colfosceril palmitate	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	A lung surfactant agent that is used as a replacement for endogenous lung surfactant. Colfosceril palmitate is effective in reducing the surface tension of pulmonary fluids, thereby increasing lung compliance properties to prevent alveolar collapse and improve breathing. This drug is used in the treatment of neonatal respiratory distress.
C0000039	measures	C0364349	1,2-dipalmitoylphosphatidylcholine	Dipalmitoylphosphatidylcholine:MCnc:Pt:Ser:Qn	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	parent_of	C2267088	1,2-dipalmitoylphosphatidylcholine	D [Preparations]	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	form_of	C4489915	1,2-dipalmitoylphosphatidylcholine	1,2-dipalmitoylphosphatidylcholine, DL-	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000039	has_component	C0364349	1,2-dipalmitoylphosphatidylcholine	Dipalmitoylphosphatidylcholine:MCnc:Pt:Ser:Qn	Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	null
C0000052	mapped_to	C0253616	1,4-alpha-Glucan Branching Enzyme	GLC3 protein, S cerevisiae	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	mapped_to	C0675638	1,4-alpha-Glucan Branching Enzyme	starch-branching enzyme II	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	mapped_to	C0761538	1,4-alpha-Glucan Branching Enzyme	starch-branching enzyme IIb	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	associated_with	C0523417	1,4-alpha-Glucan Branching Enzyme	1,4-alpha-Glucan branching enzyme measurement	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	measures	C0363784	1,4-alpha-Glucan Branching Enzyme	1,4-Alpha glucan branching enzyme:CCnc:Pt:WBC:Qn	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	measures	C4070224	1,4-alpha-Glucan Branching Enzyme	1,4-Alpha glucan branching enzyme:CCnt:Pt:Fibroblasts:Qn	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	inverse_isa	C0019495	1,4-alpha-Glucan Branching Enzyme	hexosyltransferase	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.
C0000052	inverse_isa	C0443499	1,4-alpha-Glucan Branching Enzyme	Carbohydrate metabolism disorder marker	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	has_component	C0523417	1,4-alpha-Glucan Branching Enzyme	1,4-alpha-Glucan branching enzyme measurement	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	has_measured_component	C0523417	1,4-alpha-Glucan Branching Enzyme	1,4-alpha-Glucan branching enzyme measurement	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	disposition_of	C4541016	1,4-alpha-Glucan Branching Enzyme	Transferase (disposition)	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	same_as	C0628305	1,4-alpha-Glucan Branching Enzyme	1,4-alpha-glucan 6-alpha-glucosyltransferase	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	has_component	C0363784	1,4-alpha-Glucan Branching Enzyme	1,4-Alpha glucan branching enzyme:CCnc:Pt:WBC:Qn	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	has_component	C4070224	1,4-alpha-Glucan Branching Enzyme	1,4-Alpha glucan branching enzyme:CCnt:Pt:Fibroblasts:Qn	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	null
C0000052	exhibited_by	C2256711	1,4-alpha-Glucan Branching Enzyme	glycogen branching enzyme activity	In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.	Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. [EC:2.4.1.18]
C0000084	mapped_to	C0061054	1-Carboxyglutamic Acid	gamma-glutamyl-3-carboxy-4-nitroanilide	Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.	null
C0000084	mapped_to	C0609696	1-Carboxyglutamic Acid	N-carbobenzoxy-(gamma,gamma'-di-tert-butyl)-gamma-carboxyglutamylglycine ethyl ester	Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.	null
C0000084	mapped_to	C0624352	1-Carboxyglutamic Acid	n-heptafluorobutyryl isobutyl ester of gamma-carboxyglutamic acid	Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.	null
C0000096	inverse_isa	C0031638	1-Methyl-3-isobutylxanthine	Phosphodiesterase Inhibitors	A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES	Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
C0000096	mapped_to	C0043937	1-Methyl-3-isobutylxanthine	isbufylline	A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES	null
C0000096	mapped_to	C0044419	1-Methyl-3-isobutylxanthine	1-isoamyl-3-isobutylxanthine	A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES	null
C0000096	mapped_to	C0639896	1-Methyl-3-isobutylxanthine	7-benzyl-3-(2-methylpropyl)xanthine	A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES	null
C0000097	inverse_isa	C0013036	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Dopaminergic Agents	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
C0000097	inverse_isa	C0027934	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Neurotoxins	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.
C0000097	mapped_to	C0044444	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0048671	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0080495	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0080500	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-phenyl-1,2,3,6-(tetrahydropyridine)-N-oxide	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0081018	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4'-amino-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0089511	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-phenyl-1,2,3,6-tetrahydro-3-pyridinol	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0096775	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0213585	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0249738	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-(4-methoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0289949	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1,2,3,6-tetrahydro-4-phenyl-1-((3-phenyl-3-cyclohexen-1-yl)methyl)pyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0299234	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	PD 147693	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0385683	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1,2,3,6-tetrahydro-4-(4-hydroxyphenyl)-1-((3-phenyl-3-cyclohexen-1-yl)methyl)pyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0385685	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1,2,3,6-tetrahydro-4-(p-hydroxyphenyl)-1-((3-(p-hydroxyphenyl)-3-cyclohexen-1-yl)methyl)pyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0387729	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-benzyl-1-cyclopropyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0529636	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-(4-dimethylaminophenylethenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0621704	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	N-propyl-4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0626122	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0628346	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0628348	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-ethyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0628684	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-(3-hydroxyphenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0632085	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-cyclohexyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0633123	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	2'-fluoro-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0633125	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3'-trifluoro-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0633271	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-ethyl-4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0639186	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1,3,3-trimethyl-4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0648633	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-3-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0655672	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0655676	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-cyclopropyl-1-methyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0658895	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-methyl-4-(2-(fluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	mapped_to	C0765514	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-amino-4-phenyl-1,2,3,6-tetrahydropyridine	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	see	C0000098	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-Methyl-4-phenylpyridinium	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
C0000097	inverse_isa	C0576798	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Pyridine and/or pyridine derivative	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	null
C0000097	has_causative_agent	C0270730	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	MPTP Poisoning	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.	A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
C0000098	inverse_isa	C0019236	1-Methyl-4-phenylpyridinium	Herbicides	An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.	Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.
C0000098	mapped_to	C0641039	1-Methyl-4-phenylpyridinium	1-methyl-4-(4'-acetamidophenyl)pyridinium	An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.	null
C0000098	mapped_to	C0641041	1-Methyl-4-phenylpyridinium	1-methyl-4-cyclohexylpyridinium	An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.	null
C0000098	mapped_to	C0652808	1-Methyl-4-phenylpyridinium	1-methyl-4-(2-methylphenyl)pyridinium	An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.	null
C0000098	see_from	C0000097	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.	A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
C0000102	inverse_isa	C0007090	1-Naphthylamine	Carcinogens	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
C0000102	mapped_to	C0067370	1-Naphthylamine	N,N-dimethyl-1-naphthylamine	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0068017	1-Naphthylamine	N-hydroxy-1-naphthylamine	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0068265	1-Naphthylamine	N-phenyl-1-naphthylamine	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0089115	1-Naphthylamine	1-benzoyl-2-(naphth-1-ylamino)ethene	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0170396	1-Naphthylamine	CGS 21595	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0249949	1-Naphthylamine	1,14-bis-(N-hexyl-3'-bromo-1,8'-naphthalimide-4'-yl)-1,4,11,14-tetraazatetradecane-5,10-dione	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0253333	1-Naphthylamine	4-amino-1,8-naphthalimide	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0294009	1-Naphthylamine	3-bromo-4-(hexylamino)-N-hexyl-1,8-naphthalimide	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0600985	1-Naphthylamine	lometraline	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0601381	1-Naphthylamine	N-methyl-N-1-naphthyl-2-fluoroacetamide	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0607117	1-Naphthylamine	N-heptyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthylamine methanesulfonate	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0607864	1-Naphthylamine	1,4-naphthylenediamine	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0616058	1-Naphthylamine	1,5-naphthalenediamine	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0616725	1-Naphthylamine	1-N,N-bis(beta-bromoethyl)amino-3-methylnaphthalene	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0617924	1-Naphthylamine	N-(guanin-8-yl)-1-naphthylamine	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0656020	1-Naphthylamine	FD & C Yellow 11	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0893671	1-Naphthylamine	8-dimethylamino-1-dimethylammonionaphthalene	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C0963559	1-Naphthylamine	1,8-bis(dimethylamino)naphthalene	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null
C0000102	mapped_to	C1144462	1-Naphthylamine	1-naphthylphenylamine	A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.	null

C0000039

mapped_to

C0043950

1,2-dipalmitoylphosphatidylcholine

1,3-dipalmitoyl-2-phosphatidylcholine

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

mapped_to

C0216971

1,2-dipalmitoylphosphatidylcholine

colfosceril palmitate

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

A lung surfactant agent that is used as a replacement for endogenous lung surfactant. Colfosceril palmitate is effective in reducing the surface tension of pulmonary fluids, thereby increasing lung compliance properties to prevent alveolar collapse and improve breathing. This drug is used in the treatment of neonatal respiratory distress.

C0000039

mapped_to

C0381030

1,2-dipalmitoylphosphatidylcholine

DEPN 8

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

mapped_to

C0615231

1,2-dipalmitoylphosphatidylcholine

1-palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

mapped_to

C0621533

1,2-dipalmitoylphosphatidylcholine

2-(3,6-bis(dimethylamino)-10-acridinyl)ethyl-(2,3-di-O-palmitoylglycero)phosphate

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

mapped_to

C1310941

1,2-dipalmitoylphosphatidylcholine

1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

mapped_to

C1611431

1,2-dipalmitoylphosphatidylcholine

palmitoyl-2-(N-4-nitrobenz-2-oxa-1,3-diazol)aminocaproyl-sn-glycero-3-phosphocholine

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

mapped_to

C3253442

1,2-dipalmitoylphosphatidylcholine

ETC 642

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

mapped_to

C3885037

1,2-dipalmitoylphosphatidylcholine

GLA-AF adjuvant

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

associated_with

C0523614

1,2-dipalmitoylphosphatidylcholine

Dipalmitoylphosphatidylcholine measurement

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

inverse_isa

C0031610

1,2-dipalmitoylphosphatidylcholine

Phosphatidic Acid

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

A glycerol backbone covalently bound to a phosphate group in one position, and fatty acids in the 2nd and 3rd positions. Phosphatidic acids thus have a polar head and apolar tails, and occur in cell membranes throughout nature.

C0000039

has_component

C0523614

1,2-dipalmitoylphosphatidylcholine

Dipalmitoylphosphatidylcholine measurement

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

has_measured_component

C0523614

1,2-dipalmitoylphosphatidylcholine

Dipalmitoylphosphatidylcholine measurement

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

same_as

C0216971

1,2-dipalmitoylphosphatidylcholine

colfosceril palmitate

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

A lung surfactant agent that is used as a replacement for endogenous lung surfactant. Colfosceril palmitate is effective in reducing the surface tension of pulmonary fluids, thereby increasing lung compliance properties to prevent alveolar collapse and improve breathing. This drug is used in the treatment of neonatal respiratory distress.

C0000039

measures

C0364349

1,2-dipalmitoylphosphatidylcholine

Dipalmitoylphosphatidylcholine:MCnc:Pt:Ser:Qn

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

parent_of

C2267088

1,2-dipalmitoylphosphatidylcholine

D [Preparations]

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

form_of

C4489915

1,2-dipalmitoylphosphatidylcholine

1,2-dipalmitoylphosphatidylcholine, DL-

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000039

has_component

C0364349

1,2-dipalmitoylphosphatidylcholine

Dipalmitoylphosphatidylcholine:MCnc:Pt:Ser:Qn

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.

null

C0000052

mapped_to

C0253616

1,4-alpha-Glucan Branching Enzyme

GLC3 protein, S cerevisiae

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

mapped_to

C0675638

1,4-alpha-Glucan Branching Enzyme

starch-branching enzyme II

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

mapped_to

C0761538

1,4-alpha-Glucan Branching Enzyme

starch-branching enzyme IIb

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

associated_with

C0523417

1,4-alpha-Glucan Branching Enzyme

1,4-alpha-Glucan branching enzyme measurement

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

measures

C0363784

1,4-alpha-Glucan Branching Enzyme

1,4-Alpha glucan branching enzyme:CCnc:Pt:WBC:Qn

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

measures

C4070224

1,4-alpha-Glucan Branching Enzyme

1,4-Alpha glucan branching enzyme:CCnt:Pt:Fibroblasts:Qn

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

inverse_isa

C0019495

1,4-alpha-Glucan Branching Enzyme

hexosyltransferase

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.

C0000052

inverse_isa

C0443499

1,4-alpha-Glucan Branching Enzyme

Carbohydrate metabolism disorder marker

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

has_component

C0523417

1,4-alpha-Glucan Branching Enzyme

1,4-alpha-Glucan branching enzyme measurement

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

has_measured_component

C0523417

1,4-alpha-Glucan Branching Enzyme

1,4-alpha-Glucan branching enzyme measurement

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

disposition_of

C4541016

1,4-alpha-Glucan Branching Enzyme

Transferase (disposition)

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

same_as

C0628305

1,4-alpha-Glucan Branching Enzyme

1,4-alpha-glucan 6-alpha-glucosyltransferase

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

has_component

C0363784

1,4-alpha-Glucan Branching Enzyme

1,4-Alpha glucan branching enzyme:CCnc:Pt:WBC:Qn

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

has_component

C4070224

1,4-alpha-Glucan Branching Enzyme

1,4-Alpha glucan branching enzyme:CCnt:Pt:Fibroblasts:Qn

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

null

C0000052

exhibited_by

C2256711

1,4-alpha-Glucan Branching Enzyme

glycogen branching enzyme activity

In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.

Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. [EC:2.4.1.18]

C0000084

mapped_to

C0061054

1-Carboxyglutamic Acid

gamma-glutamyl-3-carboxy-4-nitroanilide

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.

null

C0000084

mapped_to

C0609696

1-Carboxyglutamic Acid

N-carbobenzoxy-(gamma,gamma'-di-tert-butyl)-gamma-carboxyglutamylglycine ethyl ester

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.

null

C0000084

mapped_to

C0624352

1-Carboxyglutamic Acid

n-heptafluorobutyryl isobutyl ester of gamma-carboxyglutamic acid

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.

null

C0000096

inverse_isa

C0031638

1-Methyl-3-isobutylxanthine

Phosphodiesterase Inhibitors

A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

C0000096

mapped_to

C0043937

1-Methyl-3-isobutylxanthine

isbufylline

A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

null

C0000096

mapped_to

C0044419

1-Methyl-3-isobutylxanthine

1-isoamyl-3-isobutylxanthine

A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

null

C0000096

mapped_to

C0639896

1-Methyl-3-isobutylxanthine

7-benzyl-3-(2-methylpropyl)xanthine

A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

null

C0000097

inverse_isa

C0013036

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Dopaminergic Agents

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.

C0000097

inverse_isa

C0027934

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Neurotoxins

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.

C0000097

mapped_to

C0044444

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0048671

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0080495

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0080500

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-phenyl-1,2,3,6-(tetrahydropyridine)-N-oxide

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0081018

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

4'-amino-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0089511

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-phenyl-1,2,3,6-tetrahydro-3-pyridinol

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0096775

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0213585

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0249738

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

4-(4-methoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0289949

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1,2,3,6-tetrahydro-4-phenyl-1-((3-phenyl-3-cyclohexen-1-yl)methyl)pyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0299234

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

PD 147693

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0385683

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1,2,3,6-tetrahydro-4-(4-hydroxyphenyl)-1-((3-phenyl-3-cyclohexen-1-yl)methyl)pyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0385685

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1,2,3,6-tetrahydro-4-(p-hydroxyphenyl)-1-((3-(p-hydroxyphenyl)-3-cyclohexen-1-yl)methyl)pyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0387729

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

4-benzyl-1-cyclopropyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0529636

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(4-dimethylaminophenylethenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0621704

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

N-propyl-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0626122

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0628346

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0628348

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-ethyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0628684

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(3-hydroxyphenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0632085

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-cyclohexyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0633123

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

2'-fluoro-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0633125

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

3'-trifluoro-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0633271

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-ethyl-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0639186

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1,3,3-trimethyl-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0648633

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-3-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0655672

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0655676

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

4-cyclopropyl-1-methyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0658895

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(2-(fluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

mapped_to

C0765514

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-amino-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

see

C0000098

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-Methyl-4-phenylpyridinium

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

C0000097

inverse_isa

C0576798

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Pyridine and/or pyridine derivative

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

null

C0000097

has_causative_agent

C0270730

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

MPTP Poisoning

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

C0000098

inverse_isa

C0019236

1-Methyl-4-phenylpyridinium

Herbicides

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.

C0000098

mapped_to

C0641039

1-Methyl-4-phenylpyridinium

1-methyl-4-(4'-acetamidophenyl)pyridinium

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

null

C0000098

mapped_to

C0641041

1-Methyl-4-phenylpyridinium

1-methyl-4-cyclohexylpyridinium

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

null

C0000098

mapped_to

C0652808

1-Methyl-4-phenylpyridinium

1-methyl-4-(2-methylphenyl)pyridinium

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

null

C0000098

see_from

C0000097

1-Methyl-4-phenylpyridinium

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

C0000102

inverse_isa

C0007090

1-Naphthylamine

Carcinogens

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

C0000102

mapped_to

C0067370

1-Naphthylamine

N,N-dimethyl-1-naphthylamine

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0068017

1-Naphthylamine

N-hydroxy-1-naphthylamine

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0068265

1-Naphthylamine

N-phenyl-1-naphthylamine

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0089115

1-Naphthylamine

1-benzoyl-2-(naphth-1-ylamino)ethene

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0170396

1-Naphthylamine

CGS 21595

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0249949

1-Naphthylamine

1,14-bis-(N-hexyl-3'-bromo-1,8'-naphthalimide-4'-yl)-1,4,11,14-tetraazatetradecane-5,10-dione

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0253333

1-Naphthylamine

4-amino-1,8-naphthalimide

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0294009

1-Naphthylamine

3-bromo-4-(hexylamino)-N-hexyl-1,8-naphthalimide

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0600985

1-Naphthylamine

lometraline

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0601381

1-Naphthylamine

N-methyl-N-1-naphthyl-2-fluoroacetamide

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0607117

1-Naphthylamine

N-heptyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthylamine methanesulfonate

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0607864

1-Naphthylamine

1,4-naphthylenediamine

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0616058

1-Naphthylamine

1,5-naphthalenediamine

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0616725

1-Naphthylamine

1-N,N-bis(beta-bromoethyl)amino-3-methylnaphthalene

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0617924

1-Naphthylamine

N-(guanin-8-yl)-1-naphthylamine

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0656020

1-Naphthylamine

FD & C Yellow 11

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0893671

1-Naphthylamine

8-dimethylamino-1-dimethylammonionaphthalene

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C0963559

1-Naphthylamine

1,8-bis(dimethylamino)naphthalene

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null

C0000102

mapped_to

C1144462

1-Naphthylamine

1-naphthylphenylamine

A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

null