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pubmed23n0125_13777
Xenobiotic metabolism in suspensions and primary cultures of isolated hepatocytes prepared from the caudate process of bovine liver.
Isolated hepatocytes were prepared from 100- to 125-kg Holstein male calves (n = 10) by perfusion of the caudate process of the caudate lobe of the liver. The 11th or 12th rib on the right side was resected to provide exposure of the caudate process. Complete postsurgical recovery of the donor from partial lobectomy wa...
Xenobiotic metabolism in suspensions and primary cultures of isolated hepatocytes prepared from the caudate process of bovine liver. Isolated hepatocytes were prepared from 100- to 125-kg Holstein male calves (n = 10) by perfusion of the caudate process of the caudate lobe of the liver. The 11th or 12th rib on the righ...
3,767,111
pubmed23n0125_13778
Pharmacokinetic evaluation of a slow-release cefotaxime suspension in the dog and in sheep.
Three Merino ewes were given cefotaxime IM, and 3 were given cefotaxime subcutaneously (50 mg/kg of body weight each); each dose was suspended in 6 ml of oil. Five dogs were also given an oily suspension of cefotaxime subcutaneously (SC) (50 mg/kg of body weight). The plasma concentrations (Cp) and pharmacokinetic data...
Pharmacokinetic evaluation of a slow-release cefotaxime suspension in the dog and in sheep. Three Merino ewes were given cefotaxime IM, and 3 were given cefotaxime subcutaneously (50 mg/kg of body weight each); each dose was suspended in 6 ml of oil. Five dogs were also given an oily suspension of cefotaxime subcutaneo...
3,767,112
pubmed23n0125_13779
Effects of aflatoxin on the growth performance and immune responses of weanling swine.
Aflatoxin (AF)-contaminated ground corn was mixed with a commercial swine ration to yield 2 concentrations (500 mg of AFB1/kg of feed [A] and 300 mg of AFB1/kg [B]) and was fed to 2 groups of pigs. Groups A and B were fed the AF-containing ration, whereas control group C was fed the same commercial ration mixed with gr...
Effects of aflatoxin on the growth performance and immune responses of weanling swine. Aflatoxin (AF)-contaminated ground corn was mixed with a commercial swine ration to yield 2 concentrations (500 mg of AFB1/kg of feed [A] and 300 mg of AFB1/kg [B]) and was fed to 2 groups of pigs. Groups A and B were fed the AF-cont...
3,767,113
pubmed23n0125_13780
Delta-aminolevulinic acid dehydratase (EC4.3.1.24) activity in erythrocytes from cattle administered low concentrations of lead acetate.
Four different age groups of cattle, which had never been exposed to Pb, were used to determine normal age-related values for erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity. Acute or chronic Pb intoxication was experimentally induced in young calves, and their ALAD values were compared with the norma...
Delta-aminolevulinic acid dehydratase (EC4.3.1.24) activity in erythrocytes from cattle administered low concentrations of lead acetate. Four different age groups of cattle, which had never been exposed to Pb, were used to determine normal age-related values for erythrocyte delta-aminolevulinic acid dehydratase (ALAD) ...
3,767,114
pubmed23n0125_13781
Chloramphenicol concentrations in calf muscle tissue.
Twenty-five 9- to 11-week-old calves were administered 2 doses of chloramphenicol prepared in propylene glycol (13.6 mg/kg of body weight IV; 6.8 mg/kg IM; or 13.6 mg/kg IM) at 24-hour intervals. Calves were euthanatized at designated times from 2 to 72 hours after the last dose was administered. Muscle tissues were co...
Chloramphenicol concentrations in calf muscle tissue. Twenty-five 9- to 11-week-old calves were administered 2 doses of chloramphenicol prepared in propylene glycol (13.6 mg/kg of body weight IV; 6.8 mg/kg IM; or 13.6 mg/kg IM) at 24-hour intervals. Calves were euthanatized at designated times from 2 to 72 hours after ...
3,767,115
pubmed23n0125_13782
Histochemical changes in skeletal muscles of four male horses with neuromuscular disease.
Skeletal muscle biopsy specimens were taken from 4 male horses with neuromuscular disease such as myotonia congenita, chronic myositis, exertional rhabdomyolysis, and shivers. Histologic and histochemical techniques were used to evaluate skeletal muscle morphologic features and fiber-type population, size, and area, as...
Histochemical changes in skeletal muscles of four male horses with neuromuscular disease. Skeletal muscle biopsy specimens were taken from 4 male horses with neuromuscular disease such as myotonia congenita, chronic myositis, exertional rhabdomyolysis, and shivers. Histologic and histochemical techniques were used to e...
3,767,116
pubmed23n0125_13783
Relationships between stride length, stride frequency, velocity, and morphometrics of foals.
Velocity-dependent changes in stride length and frequency were studied in 19 male foals, 6 to 8 months of age, and were related to body morphometrics. Eighteen distance and 8 angle measurements were digitized from 16-mm films of standing foals. The total mass and the percentage of total mass acting through the forelimb...
Relationships between stride length, stride frequency, velocity, and morphometrics of foals. Velocity-dependent changes in stride length and frequency were studied in 19 male foals, 6 to 8 months of age, and were related to body morphometrics. Eighteen distance and 8 angle measurements were digitized from 16-mm films o...
3,767,117
pubmed23n0125_13784
The effects of occupation and smoking on respiratory disease mortality.
The effects of occupation and smoking on respiratory symptoms and ventilatory lung function were examined in 1957 among random samples of men 25 to 34 and 55 to 64 yr of age from 4 occupational categories (miners, foundry workers, mixed dust and chemical workers, and non-dust-exposed workers) living in an industrial En...
The effects of occupation and smoking on respiratory disease mortality. The effects of occupation and smoking on respiratory symptoms and ventilatory lung function were examined in 1957 among random samples of men 25 to 34 and 55 to 64 yr of age from 4 occupational categories (miners, foundry workers, mixed dust and ch...
3,767,120
pubmed23n0125_13785
Isoniazid prophylaxis in hepatitis B carriers.
Both tuberculosis and hepatitis B are endemic in southeast Asia and are common among refugees to the United States from that region. Isoniazid, used for the prophylactic treatment of tuberculosis, is a potentially hepatotoxic drug. Carriers of the hepatitis B virus are likely to have some degree of liver damage due to ...
Isoniazid prophylaxis in hepatitis B carriers. Both tuberculosis and hepatitis B are endemic in southeast Asia and are common among refugees to the United States from that region. Isoniazid, used for the prophylactic treatment of tuberculosis, is a potentially hepatotoxic drug. Carriers of the hepatitis B virus are lik...
3,767,121
pubmed23n0125_13786
Pseudomonas cepacia: decrease in colonization in patients with cystic fibrosis.
The incidence and prevalence of Pseudomonas cepacia pulmonary colonization were noted to be increasing in patients with cystic fibrosis (CF). Previous work had indicated a greater prevalence of P. cepacia among siblings (with CF) of patients colonized by P. cepacia as well as an association of initial positive P. cepac...
Pseudomonas cepacia: decrease in colonization in patients with cystic fibrosis. The incidence and prevalence of Pseudomonas cepacia pulmonary colonization were noted to be increasing in patients with cystic fibrosis (CF). Previous work had indicated a greater prevalence of P. cepacia among siblings (with CF) of patient...
3,767,122
pubmed23n0125_13787
Nutritional intervention in malnourished patients with emphysema.
We have previously reported the association of significant malnutrition with pulmonary emphysema and noted that the degree of malnutrition correlated with some measures of pulmonary function. The purpose of this study was to examine the energy requirements of malnourished patients with emphysema and acute effects of nu...
Nutritional intervention in malnourished patients with emphysema. We have previously reported the association of significant malnutrition with pulmonary emphysema and noted that the degree of malnutrition correlated with some measures of pulmonary function. The purpose of this study was to examine the energy requiremen...
3,767,123
pubmed23n0125_13788
Oxygen consumption and transport in stable patients with chronic obstructive pulmonary disease.
We studied the relationship between oxygen consumption and systemic oxygen transport in 30 clinically stable patients with chronic obstructive pulmonary disease (COPD) before and after increasing oxygen transport by passive leg elevation to raise the cardiac output. Results were compared with those observed in 10 patie...
Oxygen consumption and transport in stable patients with chronic obstructive pulmonary disease. We studied the relationship between oxygen consumption and systemic oxygen transport in 30 clinically stable patients with chronic obstructive pulmonary disease (COPD) before and after increasing oxygen transport by passive ...
3,767,124
pubmed23n0125_13789
Is respiratory mucus hypersecretion really an innocent disorder? A 22-year mortality survey of 1,061 working men.
The relation of chronic air-flow limitation and respiratory mucus hypersecretion to all causes of mortality was studied in a population of 1,061 men working in the Paris area, surveyed initially in 1960/1961, and followed for 22 yr. During this period, 369 deaths occurred; VC, FEV1, FEV1/H3, and FEV1/VC were significan...
Is respiratory mucus hypersecretion really an innocent disorder? A 22-year mortality survey of 1,061 working men. The relation of chronic air-flow limitation and respiratory mucus hypersecretion to all causes of mortality was studied in a population of 1,061 men working in the Paris area, surveyed initially in 1960/196...
3,767,125
pubmed23n0125_13790
Involuntary breath-stacking. An alternative method for vital capacity estimation in poorly cooperative subjects.
Performed correctly, the vital capacity (VC) is a useful indicator of the mechanical properties of the thorax and of neuromuscular performance. Unfortunately, its use is often limited by impaired comprehension, altered mental status, or inability to sustain forceful effort. Our purpose was to develop a measure of VC in...
Involuntary breath-stacking. An alternative method for vital capacity estimation in poorly cooperative subjects. Performed correctly, the vital capacity (VC) is a useful indicator of the mechanical properties of the thorax and of neuromuscular performance. Unfortunately, its use is often limited by impaired comprehensi...
3,767,126
pubmed23n0125_13791
Comparison of tremor responses to orally administered albuterol and terbutaline.
This study was designed to compare the initial tremor response to 4.0 mg albuterol and 5.0 mg terbutaline orally administered and to study the question of tachyphylaxis by rechallenge after 3 wk of maintenance dosing. Twenty fasting patients with severe COPD in whom orally administered sympathomimetics were withheld fo...
Comparison of tremor responses to orally administered albuterol and terbutaline. This study was designed to compare the initial tremor response to 4.0 mg albuterol and 5.0 mg terbutaline orally administered and to study the question of tachyphylaxis by rechallenge after 3 wk of maintenance dosing. Twenty fasting patien...
3,767,127
pubmed23n0125_13792
Ozone enhancement of platinum asthma in a primate model.
Three groups of adult male cynomolgus monkeys (Macaca fascicularis) were exposed to either 200 micrograms/m3 ammonium hexachloroplatinate [(NH4)2PtCl6], 200 micrograms (NH4)2PtCl6 concurrently with 1 ppm ozone (O3), or to 1 ppm O3 only. The animals were exposed by inhalation for 6 h per day, 5 days per week for 12 wk. ...
Ozone enhancement of platinum asthma in a primate model. Three groups of adult male cynomolgus monkeys (Macaca fascicularis) were exposed to either 200 micrograms/m3 ammonium hexachloroplatinate [(NH4)2PtCl6], 200 micrograms (NH4)2PtCl6 concurrently with 1 ppm ozone (O3), or to 1 ppm O3 only. The animals were exposed b...
3,767,128
pubmed23n0125_13793
Impaired exercise performance and pulmonary function in elite cyclists during low-level ozone exposure in a hot environment.
We evaluated the effects of low concentrations of ozone on the exercise performance and pulmonary function of 17 top-caliber endurance cyclists under conditions simulating competition and realistic temperature (31 degrees C). Each subject was randomly exposed to filtered air (FA), 0.12 and 0.20 ppm O3 on separate days ...
Impaired exercise performance and pulmonary function in elite cyclists during low-level ozone exposure in a hot environment. We evaluated the effects of low concentrations of ozone on the exercise performance and pulmonary function of 17 top-caliber endurance cyclists under conditions simulating competition and realist...
3,767,129
pubmed23n0125_13794
Reperfusion of ischemic dog lung results in fever, leukopenia, and lung edema.
Pulmonary artery obstruction results in minimal parenchymal abnormalities in normal lung and diminishes edema formation in dog lungs injured by oleic acid. We tested the hypothesis that reperfusion of ischemic regions would result in significant injury in normal lung and would ablate the protective effect of ischemia i...
Reperfusion of ischemic dog lung results in fever, leukopenia, and lung edema. Pulmonary artery obstruction results in minimal parenchymal abnormalities in normal lung and diminishes edema formation in dog lungs injured by oleic acid. We tested the hypothesis that reperfusion of ischemic regions would result in signifi...
3,767,130
pubmed23n0125_13795
The pathogenesis of experimental pulmonary histoplasmosis. Correlative studies of histopathology, bronchoalveolar lavage, and respiratory function.
A murine model of acute pulmonary histoplasmosis was employed to study the pathogenesis of the disease process by means of histopathology, bronchoalveolar lavage, and respiratory function tests. These studies were performed on C57BL/6 mice from 8 h to 8 wk after intranasal inoculation of 10(5) yeast forms of Histoplasm...
The pathogenesis of experimental pulmonary histoplasmosis. Correlative studies of histopathology, bronchoalveolar lavage, and respiratory function. A murine model of acute pulmonary histoplasmosis was employed to study the pathogenesis of the disease process by means of histopathology, bronchoalveolar lavage, and respi...
3,767,131
pubmed23n0125_13796
Airways hyperreactivity and inflammation produced by aerosolization of human C5A des arg.
The premise of this study was that complement fragments would lead to granulocyte infiltration and to associated changes in airways reactivity. Inflammation was induced in large airways (greater than 1.0 mm) by aerosolization of the complement chemotactic factor, C5a des arg, which was isolated from activated human ser...
Airways hyperreactivity and inflammation produced by aerosolization of human C5A des arg. The premise of this study was that complement fragments would lead to granulocyte infiltration and to associated changes in airways reactivity. Inflammation was induced in large airways (greater than 1.0 mm) by aerosolization of t...
3,767,132
pubmed23n0125_13797
Nontraumatic fat embolization. A rare cause of new pulmonary infiltrates in an immunocompromised patient.
Diffuse pulmonary infiltrates and hypoxemia are common in immunocompromised patients. We describe a patient with lymphoma who developed hypoxemia and diffuse pulmonary infiltrates during treatment with corticosteroids. Open lung biopsy and postmortem examination indicated that the cause of the infiltrates was nontrauma...
Nontraumatic fat embolization. A rare cause of new pulmonary infiltrates in an immunocompromised patient. Diffuse pulmonary infiltrates and hypoxemia are common in immunocompromised patients. We describe a patient with lymphoma who developed hypoxemia and diffuse pulmonary infiltrates during treatment with corticostero...
3,767,133
pubmed23n0125_13798
Sarcoidosis simulating pulmonary veno-occlusive disease.
We describe a young woman who presented with a 6-month history of progressive pulmonary hypertension. At autopsy she was found to have noncaseating granulomas obliterating pulmonary veins, without granulomatous involvement of pulmonary arteries. Noncaseating granulomas were also present in the liver and hilar lymph nod...
Sarcoidosis simulating pulmonary veno-occlusive disease. We describe a young woman who presented with a 6-month history of progressive pulmonary hypertension. At autopsy she was found to have noncaseating granulomas obliterating pulmonary veins, without granulomatous involvement of pulmonary arteries. Noncaseating gran...
3,767,134
pubmed23n0125_13799
Delayed skin oxygenation following distal tibial revascularization (DTR). Implications for wound healing in late amputations.
This article summarizes the authors' experience with prospective transcutaneous oxygen mapping (PtcO2 mm Hg) in patients requiring distal tibial revascularization. Simultaneous measurements were performed measuring preoperatively and early (1-3 days) and late (5-8 days) postoperatively in eight patients undergoing DTR ...
Delayed skin oxygenation following distal tibial revascularization (DTR). Implications for wound healing in late amputations. This article summarizes the authors' experience with prospective transcutaneous oxygen mapping (PtcO2 mm Hg) in patients requiring distal tibial revascularization. Simultaneous measurements were...
3,767,137
pubmed23n0125_13800
Role of preoperative hemodynamic monitoring in intraoperative fluid management.
In this study the hemodynamic factors which contribute to postoperative mortality and morbidity were evaluated in 41 patients. Preoperative data were prospectively collected over a 5-year period. The patients underwent vascular and general surgical operative procedures. Among them, 23 patients had minor or no postopera...
Role of preoperative hemodynamic monitoring in intraoperative fluid management. In this study the hemodynamic factors which contribute to postoperative mortality and morbidity were evaluated in 41 patients. Preoperative data were prospectively collected over a 5-year period. The patients underwent vascular and general ...
3,767,138
pubmed23n0125_13801
Electrocardiographic changes in cardiac patients with acute gallbladder disease.
Acute cholecystitis or biliary colic may be associated with angina pectoris, arrhythmias, or nonspecific ST-T wave changes on the electrocardiogram. A vagally mediated cardio-biliary reflex is the presumed cause of these changes. Three cases of acute exacerbation of biliary tract disease in patients with known coronary...
Electrocardiographic changes in cardiac patients with acute gallbladder disease. Acute cholecystitis or biliary colic may be associated with angina pectoris, arrhythmias, or nonspecific ST-T wave changes on the electrocardiogram. A vagally mediated cardio-biliary reflex is the presumed cause of these changes. Three cas...
3,767,139
pubmed23n0125_13802
Quality assessment of tetanus prophylaxis in the wounded patient.
New guidelines on tetanus prophylaxis in wound management have been prepared by the American College of Surgeons and are available in a poster format or in bulletins. The purpose of this study was to determine the impact of these educational brochures on tetanus prophylaxis in a hospital setting. The results of this st...
Quality assessment of tetanus prophylaxis in the wounded patient. New guidelines on tetanus prophylaxis in wound management have been prepared by the American College of Surgeons and are available in a poster format or in bulletins. The purpose of this study was to determine the impact of these educational brochures on...
3,767,140
pubmed23n0125_13803
Pelvic fractures at a community hospital.
One hundred twenty-eight pelvic fractures were reviewed. Of the 128 patients with pelvic fractures, there were seven deaths. Pelvic fractures associated with the greatest blood loss and complications were those which occurred in crush-type injuries secondary to automobile accidents or other heavy impact injuries. Unles...
Pelvic fractures at a community hospital. One hundred twenty-eight pelvic fractures were reviewed. Of the 128 patients with pelvic fractures, there were seven deaths. Pelvic fractures associated with the greatest blood loss and complications were those which occurred in crush-type injuries secondary to automobile accid...
3,767,141
pubmed23n0125_13804
Perforated gastric ulcers. A retrospective study of 32 patients.
During the last 6 years the authors have treated 99 patients with perforated peptic ulcers. Sixty-six patients had perforated pyloro-duodenal ulcers, while 32 patients were treated for perforated gastric ulcers, a ratio of 2:1. This article deals with the gastric ulcers treated by a surgical unit in an urban, 600-bed m...
Perforated gastric ulcers. A retrospective study of 32 patients. During the last 6 years the authors have treated 99 patients with perforated peptic ulcers. Sixty-six patients had perforated pyloro-duodenal ulcers, while 32 patients were treated for perforated gastric ulcers, a ratio of 2:1. This article deals with the...
3,767,142
pubmed23n0125_13805
The competence and bacteriologic effect of the telescoped intestinal valve after small bowel resection.
In 20 dogs the distal one-third of the small intestine and the proximal 10 cm of the ascending colon were resected. Bowel continuity was established by the telescoping technique to create an intestinal valve in ten dogs (group A) and by conventional end-to-end anastomosis in ten dogs (group B). Diarrhea and weight loss...
The competence and bacteriologic effect of the telescoped intestinal valve after small bowel resection. In 20 dogs the distal one-third of the small intestine and the proximal 10 cm of the ascending colon were resected. Bowel continuity was established by the telescoping technique to create an intestinal valve in ten d...
3,767,143
pubmed23n0125_13806
Splanchnic hemodynamic changes after the distal spleno renal shunt.
Marked changes in preoperative to postoperative corrected sinusoidal pressures (CSP) occurred in 51 per cent of a series of 51 patients undergoing the distal splenorenal shunt. Twenty patients who had the highest incidence of partial portal vein thrombosis, (48%--Group I), showed minimal pre- to postoperative changes i...
Splanchnic hemodynamic changes after the distal spleno renal shunt. Marked changes in preoperative to postoperative corrected sinusoidal pressures (CSP) occurred in 51 per cent of a series of 51 patients undergoing the distal splenorenal shunt. Twenty patients who had the highest incidence of partial portal vein thromb...
3,767,144
pubmed23n0125_13807
Isolation and partial characterization of a protein fraction from the opossum (Didelphis marsupialis) serum, with protecting property against the Bothrops jararaca snake venom.
Two separated methods were used to purify a fraction from the opossum (Didelphis marsupialis) serum able to protect mice against Bothrops jararaca venom. The first of them included an initial batch DEAE-Cellulose ion-exchange of the serum, followed by another ion-exchange chromatography on a Carboxymethyl Sepharose col...
Isolation and partial characterization of a protein fraction from the opossum (Didelphis marsupialis) serum, with protecting property against the Bothrops jararaca snake venom. Two separated methods were used to purify a fraction from the opossum (Didelphis marsupialis) serum able to protect mice against Bothrops jarar...
3,767,145
pubmed23n0125_13808
Intravenous propafenone for termination of reentrant supraventricular tachycardia. A placebo-controlled, randomized, double-blind, crossover study.
To assess the antiarrhythmic efficacy of intravenous propafenone, 20 patients with inducible sustained supraventricular tachycardia received propafenone, 2 mg/kg body weight, or placebo in a double-blind, randomized, crossover study. Three patients had intra-atrial reentrant tachycardia, 3 had atrioventricular nodal re...
Intravenous propafenone for termination of reentrant supraventricular tachycardia. A placebo-controlled, randomized, double-blind, crossover study. To assess the antiarrhythmic efficacy of intravenous propafenone, 20 patients with inducible sustained supraventricular tachycardia received propafenone, 2 mg/kg body weigh...
3,767,146
pubmed23n0125_13809
Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis.
The effects of peripheral cold exposure on myocardial perfusion and function were studied in 13 patients with scleroderma without clinically evident myocardial disease. Ten patients had at least one transient, cold-induced, myocardial perfusion defect visualized by thallium-201 scintigraphy, and 12 had reversible, cold...
Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis. The effects of peripheral cold exposure on myocardial perfusion and function were studied in 13 patients with scleroderma without clinically evident myocardial disease. Ten patients had at least one transient, cold-induced...
3,767,147
pubmed23n0125_13810
Aeromonas intestinal infections in the United States.
To evaluate the clinical and epidemiologic aspects of aeromonas enteritis, we studied the cases of 34 persons nationwide from whom Aeromonas hydrophila had been isolated in large numbers from stool in 1984. Compared with 68 control subjects, these patients were more likely to have drunk untreated water, usually from pr...
Aeromonas intestinal infections in the United States. To evaluate the clinical and epidemiologic aspects of aeromonas enteritis, we studied the cases of 34 persons nationwide from whom Aeromonas hydrophila had been isolated in large numbers from stool in 1984. Compared with 68 control subjects, these patients were more...
3,767,148
pubmed23n0125_13811
Plesiomonas enteric infections in the United States.
Thirty-one persons nationwide from whom Plesiomonas shigelloides was isolated in large numbers from stool in 1984 were compared with 62 matched control subjects. Infection with P. shigelloides was strongly associated with eating uncooked shellfish, usually raw oysters, in the 48 hours before the onset of illness (p les...
Plesiomonas enteric infections in the United States. Thirty-one persons nationwide from whom Plesiomonas shigelloides was isolated in large numbers from stool in 1984 were compared with 62 matched control subjects. Infection with P. shigelloides was strongly associated with eating uncooked shellfish, usually raw oyster...
3,767,149
pubmed23n0125_13812
Clinically silent atrial septal defects with evidence for cerebral embolization.
The cause of stroke in young patients frequently cannot be established. Eleven consecutive patients, age 50 and younger, had clinical evidence of cerebral embolization. Results of physical, radiographic, electrocardiographic, and two-dimensional echocardiographic examinations were normal in all patients. During normal ...
Clinically silent atrial septal defects with evidence for cerebral embolization. The cause of stroke in young patients frequently cannot be established. Eleven consecutive patients, age 50 and younger, had clinical evidence of cerebral embolization. Results of physical, radiographic, electrocardiographic, and two-dimen...
3,767,150
pubmed23n0125_13813
Assessing clinical skills of residents with standardized patients.
Current techniques do not provide a reproducible, reliable, or valid basis for assessing clinical skills. The need for large-scale direct observation and standardized assessment procedures has precluded development of better techniques. A project using standardized patients presenting with common clinical problems eval...
Assessing clinical skills of residents with standardized patients. Current techniques do not provide a reproducible, reliable, or valid basis for assessing clinical skills. The need for large-scale direct observation and standardized assessment procedures has precluded development of better techniques. A project using ...
3,767,153
pubmed23n0125_13814
Digitalis and diuretics: still the standard therapy?
Although digitalis preparations are effective in controlling the ventricular rate in atrial fibrillation and certain other supraventricular tachyarrhythmias, with consequent haemodynamic benefit, there is increasing controversy about significant sustained inotropic efficacy in patients in sinus rhythm. Digoxin toxicity...
Digitalis and diuretics: still the standard therapy? Although digitalis preparations are effective in controlling the ventricular rate in atrial fibrillation and certain other supraventricular tachyarrhythmias, with consequent haemodynamic benefit, there is increasing controversy about significant sustained inotropic e...
3,767,182
pubmed23n0125_13815
Idiopathic calcium urolithiasis: genetic aspects.
Seventy-nine stone-formers underwent a metabolic investigation and ABO blood group determination. Incidence of blood groups in patients was similar to ABO phenotypes distribution in general population. The 37.7 p. 100 showed family history for stones. Idiopathic hypercalciuria was present in 40.3 p. 100 of cases; stone...
Idiopathic calcium urolithiasis: genetic aspects. Seventy-nine stone-formers underwent a metabolic investigation and ABO blood group determination. Incidence of blood groups in patients was similar to ABO phenotypes distribution in general population. The 37.7 p. 100 showed family history for stones. Idiopathic hyperca...
3,767,183
pubmed23n0125_13816
[Clinical value of assays of parathyroid hormone and 25-hydroxyvitamin D in internal medicine].
Over a 3 years period, PTH, 25 OHD, calcium and phosphate levels were measured in all patients admitted to a department of Internal Medicine with abnormal phospho-calcic metabolism or bone disease. The diagnostic value of iPTH was analysed, especially in cases of hyper- and hypocalcaemia. In hypercalcaemia, the iPTH di...
[Clinical value of assays of parathyroid hormone and 25-hydroxyvitamin D in internal medicine]. Over a 3 years period, PTH, 25 OHD, calcium and phosphate levels were measured in all patients admitted to a department of Internal Medicine with abnormal phospho-calcic metabolism or bone disease. The diagnostic value of iP...
3,767,184
pubmed23n0125_13817
Studies on the hydroxylation of vitamin D in man.
The authors have studied some of the factors influencing vitamin D hydroxylases in man, using two indirect experimental approaches. In the first study they have considered the effect of a long-term treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the serum levels of 25-hydroxyvitamin D (25-OHD) in postmenopausa...
Studies on the hydroxylation of vitamin D in man. The authors have studied some of the factors influencing vitamin D hydroxylases in man, using two indirect experimental approaches. In the first study they have considered the effect of a long-term treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the serum level...
3,767,185
pubmed23n0125_13818
Vitamin D status in the extreme age of life.
The aim of the present study was to investigate vitamin D status in the extreme age of life and to assess the ability of elderly people to synthesize vitamin D in skin, in response to artificial ultraviolet irradiation, and to hydroxylate the newly synthesized vitamin in the liver. The authors have determined the serum...
Vitamin D status in the extreme age of life. The aim of the present study was to investigate vitamin D status in the extreme age of life and to assess the ability of elderly people to synthesize vitamin D in skin, in response to artificial ultraviolet irradiation, and to hydroxylate the newly synthesized vitamin in the...
3,767,186
pubmed23n0125_13819
[Bone involvement in hypothyroidism in adults. Apropos of 20 patients].
Although bone changes in hyperthyroidism are well known, they have been much less studied in hypothyroidism and we set out to establish whether they did occur in the latter condition. We present the results of a prospective study of 20 adult patients, with acquired primary hypothyroidism. No changes in urinary or blood...
[Bone involvement in hypothyroidism in adults. Apropos of 20 patients]. Although bone changes in hyperthyroidism are well known, they have been much less studied in hypothyroidism and we set out to establish whether they did occur in the latter condition. We present the results of a prospective study of 20 adult patien...
3,767,187
pubmed23n0125_13820
[Renal lithiasis in idiopathic hypercalciuria and primary hyperparathyroidism].
The high incidence of renal lithiasis in hyperparathyroidism (55 p. 100) suggests that PTH plays a causal role in stone production. It also motivates a systematic search for primary hyperparathyroidism in all patients with renal stones although it is only found in about 7 p. 100 of cases. PTH acts through the stimulati...
[Renal lithiasis in idiopathic hypercalciuria and primary hyperparathyroidism]. The high incidence of renal lithiasis in hyperparathyroidism (55 p. 100) suggests that PTH plays a causal role in stone production. It also motivates a systematic search for primary hyperparathyroidism in all patients with renal stones alth...
3,767,188
pubmed23n0125_13821
[Sensitivity of bone to parathyroid hormone in type I pseudohypoparathyroidism. 6 cases].
The sensitivity of bone to parathormone in pseudoparathyroidism is not well known. Six patients with Type I pseudohypoparathyroidism (4 with Albright's osteodystrophy) had increased alkaline phosphatase levels (5 patients) and radiological signs of periosteal resorption in the hand in one case. All patients had histolo...
[Sensitivity of bone to parathyroid hormone in type I pseudohypoparathyroidism. 6 cases]. The sensitivity of bone to parathormone in pseudoparathyroidism is not well known. Six patients with Type I pseudohypoparathyroidism (4 with Albright's osteodystrophy) had increased alkaline phosphatase levels (5 patients) and rad...
3,767,189
pubmed23n0125_13822
Diagnosis and treatment of heart failure in different European countries: a young AEMIE questionnaire.
To compare diagnosis and treatment of heart failure among different European countries, an anonymous questionnaire was developed and sent to young AEMIE members all over Europe. 159 filled-in questionnaires were received: 30 p. 100 from France (F), 25 p. 100 from Great Britain (GB), 21 p. 100 from the Benelux countries...
Diagnosis and treatment of heart failure in different European countries: a young AEMIE questionnaire. To compare diagnosis and treatment of heart failure among different European countries, an anonymous questionnaire was developed and sent to young AEMIE members all over Europe. 159 filled-in questionnaires were recei...
3,767,190
pubmed23n0125_13823
New inotropic-vasodilating drugs in acute and chronic heart failure.
Clinical trials with new inotropic, non-adrenergic agents with vasodilating properties have open new perspectives for the treatment of acute and chronic heart failure. If their mechanism of action is not exactly known, they are likely to increase C.AMP by phosphodiesterase inhibition. A clear distinction has to be made...
New inotropic-vasodilating drugs in acute and chronic heart failure. Clinical trials with new inotropic, non-adrenergic agents with vasodilating properties have open new perspectives for the treatment of acute and chronic heart failure. If their mechanism of action is not exactly known, they are likely to increase C.AM...
3,767,191
pubmed23n0125_13824
[Usefulness of ambulatory blood pressure monitoring in hypertensive patients].
Treated or untreated hypertensive patients may have very different blood pressure levels when measured by the doctor in his surgery and when measured by ambulatory monitoring during their usual everyday activities. It is now possible to record blood pressure non-invasively with a portable blood pressure measuring devic...
[Usefulness of ambulatory blood pressure monitoring in hypertensive patients]. Treated or untreated hypertensive patients may have very different blood pressure levels when measured by the doctor in his surgery and when measured by ambulatory monitoring during their usual everyday activities. It is now possible to reco...
3,767,192
pubmed23n0125_13825
[Respiratory encephalopathy].
Encephalopathy is a common and sometimes a presenting feature of decompensated chronic respiratory failure. There is a wide number of clinical and paraclinical signs of this condition and four grades of severity without a close correlation with blood gas changes. This condition is the consequence of complex metabolic a...
[Respiratory encephalopathy]. Encephalopathy is a common and sometimes a presenting feature of decompensated chronic respiratory failure. There is a wide number of clinical and paraclinical signs of this condition and four grades of severity without a close correlation with blood gas changes. This condition is the cons...
3,767,193
pubmed23n0125_13826
[Endocrine encephalopathies].
Endocrine encephalopathy, excepting hypoglycaemia and diabetes mellitus, is usually the clinical expression of non specific neuronal suffering secondary to a severe endocrine disturbance. The presentation is sometimes atypical and the prognosis poor but reversible with appropriate treatment; the condition should be rec...
[Endocrine encephalopathies]. Endocrine encephalopathy, excepting hypoglycaemia and diabetes mellitus, is usually the clinical expression of non specific neuronal suffering secondary to a severe endocrine disturbance. The presentation is sometimes atypical and the prognosis poor but reversible with appropriate treatmen...
3,767,195
pubmed23n0125_13827
Cryoglobulinaemia: clinical features and response to treatment.
We report the clinical features and outcome of 16 patients with cryoglobulinaemia. Two patients with Type I cryoglobulinaemia both had IgG kappa monoclonal paraproteins. Nine of 10 with Type II disease had monoclonal IgM kappa and polyclonal IgG; one had monoclonal IgG kappa and polyclonal IgG in the cryoglobulin. Unde...
Cryoglobulinaemia: clinical features and response to treatment. We report the clinical features and outcome of 16 patients with cryoglobulinaemia. Two patients with Type I cryoglobulinaemia both had IgG kappa monoclonal paraproteins. Nine of 10 with Type II disease had monoclonal IgM kappa and polyclonal IgG; one had m...
3,767,196
pubmed23n0125_13828
Cryoproteins.
Proteins producing phenomena after exposure to the cold are reviewed but concentrating mainly on those that can produce aggregates within the laboratory. From three large series the frequencies were I. Mixed Cryoglobulins (polyclonal 50 p. 100, monoclonal 18 p. 100); II. Monoclonal Cryoglobulin (25 p. 100); III. Cryofi...
Cryoproteins. Proteins producing phenomena after exposure to the cold are reviewed but concentrating mainly on those that can produce aggregates within the laboratory. From three large series the frequencies were I. Mixed Cryoglobulins (polyclonal 50 p. 100, monoclonal 18 p. 100); II. Monoclonal Cryoglobulin (25 p. 100...
3,767,197
pubmed23n0125_13829
Lack of correlation of glycosylated haemoglobin level with the duration of diabetes or diabetic angiopathy.
Patients with severe diabetic angiopathy show an increased physiologic haemolysis. The aim of the present study was to evaluate the practical influence of the resulting reduced red cells half-life on the glycosylated haemoglobin (GHb) level as determined by a routine method. 168 diabetics, aged 55.7 +/- 1.3 years, were...
Lack of correlation of glycosylated haemoglobin level with the duration of diabetes or diabetic angiopathy. Patients with severe diabetic angiopathy show an increased physiologic haemolysis. The aim of the present study was to evaluate the practical influence of the resulting reduced red cells half-life on the glycosyl...
3,767,198
pubmed23n0125_13830
An algorithm for differential diagnosis in jaundice and its applications.
During the recent years a broad spectrum of diagnostic methods have appeared for the differentiation of obstructive and nonobstructive jaundice: ultrasound examination, CT-scan, direct cholangiography, etc. These investigations are costly and not without risks. It is therefore essential to devise an optimal diagnostic ...
An algorithm for differential diagnosis in jaundice and its applications. During the recent years a broad spectrum of diagnostic methods have appeared for the differentiation of obstructive and nonobstructive jaundice: ultrasound examination, CT-scan, direct cholangiography, etc. These investigations are costly and not...
3,767,199
pubmed23n0125_13831
[Simulation of mental disorders. 1. Psychopathologic and psychosociodynamic aspects in a military environment].
In this paper, the author studies the malingering as a problem in the relationship between the doctor, patients and environment. Our field is the military community. After descriptive approach in the psychopathological disorders, the psychopathological and psychodynamic points of view give us the possibility to reach t...
[Simulation of mental disorders. 1. Psychopathologic and psychosociodynamic aspects in a military environment]. In this paper, the author studies the malingering as a problem in the relationship between the doctor, patients and environment. Our field is the military community. After descriptive approach in the psychopa...
3,767,204
pubmed23n0125_13832
[Application of D.S.M. III to prison psychiatry: apropos of 100 diagnostic evaluations].
From hundred diagnostic evaluations according to D.S.M.-III classification, the authors bring to light the frequency of psychiatric disorders among the prisoners. "Substance use disorder" (axis 1) and "antisocial personality" (axis 2) are the more frequent diagnosis and they are often associated. "Schizophrenic disorde...
[Application of D.S.M. III to prison psychiatry: apropos of 100 diagnostic evaluations]. From hundred diagnostic evaluations according to D.S.M.-III classification, the authors bring to light the frequency of psychiatric disorders among the prisoners. "Substance use disorder" (axis 1) and "antisocial personality" (axis...
3,767,207
pubmed23n0125_13833
Neodymium: YAG laser surgery: the treatment of pediatric cataract disease.
Cataract extraction in children has undergone dramatic changes during the past 20 years, largely as a result of technologic advances. The neodymium: yttrium aluminum garnet (Nd:YAG) laser has indirectly brought the surgical technique full circle. The posterior capsule may be preserved at surgery and treated successfull...
Neodymium: YAG laser surgery: the treatment of pediatric cataract disease. Cataract extraction in children has undergone dramatic changes during the past 20 years, largely as a result of technologic advances. The neodymium: yttrium aluminum garnet (Nd:YAG) laser has indirectly brought the surgical technique full circle...
3,767,208
pubmed23n0125_13834
Optic disc edema and Lyme disease.
A seven-year-old child developed a febrile rash, migratory arthritis, and neurologic signs. Three days earlier, the child had been bitten by a tick. An eye examination two months later revealed bilateral papilledema, although the cerebrospinal fluid pressure was 170 mm. The IgM antibody titer for the Ixodes dammini spi...
Optic disc edema and Lyme disease. A seven-year-old child developed a febrile rash, migratory arthritis, and neurologic signs. Three days earlier, the child had been bitten by a tick. An eye examination two months later revealed bilateral papilledema, although the cerebrospinal fluid pressure was 170 mm. The IgM antibo...
3,767,210
pubmed23n0125_13835
Neurosyphilis and retrobulbar neuritis in a patient with AIDS.
A 33-year-old homosexual patient with acquired immune deficiency syndrome (AIDS) developed sudden unilateral loss of vision. Slit-lamp and funduscopic examination of the affected eye was completely within normal limits. The patient, however, had a Marcus Gunn pupil, decreased color vision, and a large central scotoma o...
Neurosyphilis and retrobulbar neuritis in a patient with AIDS. A 33-year-old homosexual patient with acquired immune deficiency syndrome (AIDS) developed sudden unilateral loss of vision. Slit-lamp and funduscopic examination of the affected eye was completely within normal limits. The patient, however, had a Marcus Gu...
3,767,211
pubmed23n0125_13836
Opportunistic infections of the retina and posterior segment.
Opportunistic infections of the retina are becoming a more frequent diagnostic and therapeutic challenge as immunosuppressed patients become more common. Viral, fungal, protozoan, and bacterial agents may be encountered. Diagnostic and therapeutic considerations, illustrated by case histories, are presented in this art...
Opportunistic infections of the retina and posterior segment. Opportunistic infections of the retina are becoming a more frequent diagnostic and therapeutic challenge as immunosuppressed patients become more common. Viral, fungal, protozoan, and bacterial agents may be encountered. Diagnostic and therapeutic considerat...
3,767,212
pubmed23n0125_13837
Posterior decompensation syndrome: macular failure versus senile macular degeneration.
Macular cone death in adults is caused by failure of the system that carries away the retinal biologic wastes. This failure may be termed the posterior decompensation syndrome, a name intended to convey the dynamic concept of imbalance between formation and elimination of waste. Because of centripetal fluid flow in the...
Posterior decompensation syndrome: macular failure versus senile macular degeneration. Macular cone death in adults is caused by failure of the system that carries away the retinal biologic wastes. This failure may be termed the posterior decompensation syndrome, a name intended to convey the dynamic concept of imbalan...
3,767,213
pubmed23n0125_13838
Anatomy of the round window niche.
The contributing elements to boundaries of the round window niche are superiorly the tegmen fossula fenestra rotunda (roof support), inferiorly the fustis (depth) and area concamerata, anteriorly the sustentaculum (support) and postis anterior (anterior pillar), and posteriorly the postis posterior (posterior pillar) a...
Anatomy of the round window niche. The contributing elements to boundaries of the round window niche are superiorly the tegmen fossula fenestra rotunda (roof support), inferiorly the fustis (depth) and area concamerata, anteriorly the sustentaculum (support) and postis anterior (anterior pillar), and posteriorly the po...
3,767,214
pubmed23n0125_13839
Middle cranial fossa acoustic neuroma excision: results and complications.
The middle cranial fossa surgical approach has been used for the removal of acoustic neuromas in 43 patients at the University of Iowa since 1974. Hearing was maintained in 50% of patients with tumors 1.5 cm or less outside the porus acusticus. Postoperative hearing, facial nerve function, and complications were simila...
Middle cranial fossa acoustic neuroma excision: results and complications. The middle cranial fossa surgical approach has been used for the removal of acoustic neuromas in 43 patients at the University of Iowa since 1974. Hearing was maintained in 50% of patients with tumors 1.5 cm or less outside the porus acusticus. ...
3,767,216
pubmed23n0125_13840
Verrucous carcinoma of the temporal bone.
Verrucous carcinoma, a familiar lesion of the oral cavity and larynx, is distinctly rare in the ear. We report five cases of verrucous carcinoma of the temporal bone, each of which fulfills Ackerman's histologic and biologic criteria. Only three cases of verrucous carcinoma of the ear have been previously reported. Mos...
Verrucous carcinoma of the temporal bone. Verrucous carcinoma, a familiar lesion of the oral cavity and larynx, is distinctly rare in the ear. We report five cases of verrucous carcinoma of the temporal bone, each of which fulfills Ackerman's histologic and biologic criteria. Only three cases of verrucous carcinoma of ...
3,767,215
pubmed23n0125_13841
Histologic findings in two very small intracanalicular solitary schwannomas of the eighth nerve.
Two very small intracanalicular tumors, resected en bloc with the complete eighth nerve, were serially sectioned in order to study the relationship between the tumors and the nerves of origin. Both cases met the size criteria for hearing conservation surgery; however, the patient with the smaller tumor and the better h...
Histologic findings in two very small intracanalicular solitary schwannomas of the eighth nerve. Two very small intracanalicular tumors, resected en bloc with the complete eighth nerve, were serially sectioned in order to study the relationship between the tumors and the nerves of origin. Both cases met the size criter...
3,767,217
pubmed23n0125_13842
Stapedectomy results in a residency training program.
As the total number of stapedectomy procedures has declined, the adequacy of residency training for this procedure must be evaluated. Results of 5 years of stapedectomies performed by the resident otology service at the Massachusetts Eye and Ear Infirmary from Oct 1, 1979, through Sept 30, 1984, are reviewed and compar...
Stapedectomy results in a residency training program. As the total number of stapedectomy procedures has declined, the adequacy of residency training for this procedure must be evaluated. Results of 5 years of stapedectomies performed by the resident otology service at the Massachusetts Eye and Ear Infirmary from Oct 1...
3,767,219
pubmed23n0125_13843
Perilymphatic fistula: a histopathologic study.
Over the last two decades, clinical criteria for perilymphatic fistulae have been defined to the extent that differentiation can be made between such fistulae and other balance-affecting disorders such as Meniere's syndrome. On the assumption that the specimens in the temporal bone bank of the University of Chicago Med...
Perilymphatic fistula: a histopathologic study. Over the last two decades, clinical criteria for perilymphatic fistulae have been defined to the extent that differentiation can be made between such fistulae and other balance-affecting disorders such as Meniere's syndrome. On the assumption that the specimens in the tem...
3,767,218
pubmed23n0125_13844
Diagnosis and management of anomalies of the craniovertebral junction.
The term craniovertebral junction refers to an area comprising the inferior portion of the occipital bone surrounding the foramen magnum and the first two cervical vertebrae. A variety of anomalies of bony, meningeal, and neural elements are known to occur in this region, producing a wide spectrum of clinical symptoms....
Diagnosis and management of anomalies of the craniovertebral junction. The term craniovertebral junction refers to an area comprising the inferior portion of the occipital bone surrounding the foramen magnum and the first two cervical vertebrae. A variety of anomalies of bony, meningeal, and neural elements are known t...
3,767,220
pubmed23n0125_13845
[Incontinentia pigmenti. Study of 3 families].
Ten cases of incontinentia pigmenti are reported. All patients, corresponding to three families, were female. In one case a Turner's syndrome phenotype (XO) with mosaicism 46 XX/46 X; i (Xq) was observed. This finding seems to confirm that the disease is transmitted through a dominant gene carried on the X chromosome. ...
[Incontinentia pigmenti. Study of 3 families]. Ten cases of incontinentia pigmenti are reported. All patients, corresponding to three families, were female. In one case a Turner's syndrome phenotype (XO) with mosaicism 46 XX/46 X; i (Xq) was observed. This finding seems to confirm that the disease is transmitted throug...
3,767,228
pubmed23n0125_13846
Clinical use of an insert earphone.
There are several applications of and advantages to using an insert earphone. An insert earphone has three parts: a transducer to convert electrical energy to sound, a conduit to deliver the sound into the ear canal, and a coupler connecting the device to the canal. The data from this study indicate that there is a dis...
Clinical use of an insert earphone. There are several applications of and advantages to using an insert earphone. An insert earphone has three parts: a transducer to convert electrical energy to sound, a conduit to deliver the sound into the ear canal, and a coupler connecting the device to the canal. The data from thi...
3,767,222
pubmed23n0125_13847
Comparative study of age-related cochlear hair cell loss.
Age-related hair cell loss has been studied in squirrel monkeys using surface preparation of the organ of Corti. Increasing hair cell loss starting at the apex is seen as a function of age. This finding is discussed in the light of our studies in guinea pigs, chinchillas, and rabbits. Reviewed with other human and expe...
Comparative study of age-related cochlear hair cell loss. Age-related hair cell loss has been studied in squirrel monkeys using surface preparation of the organ of Corti. Increasing hair cell loss starting at the apex is seen as a function of age. This finding is discussed in the light of our studies in guinea pigs, ch...
3,767,221
pubmed23n0125_13848
[Association of a pediatric bullous eruption, cutaneous and muscular atrophy, hyperpigmentation and dysmorphism. A new entity?].
We report the case of a young patient who presented with dysmorphism, bullous eruption of childhood, cutaneous and muscular atrophy and hyperpigmentation. Attempts were made to find out where this case fits in the nosological framework. This young boy without any particular family history was born with facial dysmorphi...
[Association of a pediatric bullous eruption, cutaneous and muscular atrophy, hyperpigmentation and dysmorphism. A new entity?]. We report the case of a young patient who presented with dysmorphism, bullous eruption of childhood, cutaneous and muscular atrophy and hyperpigmentation. Attempts were made to find out where...
3,767,229
pubmed23n0125_13849
[Cutaneous expansion by inflatable implant].
The capacity of the skin to stretch and expand, as shown in pregnancy, has been used by Radovan who, in 1976, introduced skin expanders made of silicone. These are empty balloons of different sizes and shapes which are surgically placed under the skin and gradually filled with saline. The saline solution is introduced ...
[Cutaneous expansion by inflatable implant]. The capacity of the skin to stretch and expand, as shown in pregnancy, has been used by Radovan who, in 1976, introduced skin expanders made of silicone. These are empty balloons of different sizes and shapes which are surgically placed under the skin and gradually filled wi...
3,767,230
pubmed23n0125_13850
Effect of conductive hearing loss and middle ear surgery on binaural hearing.
This study investigated whether conductive hearing loss reduces normal binaural hearing advantages and whether binaural hearing advantages are normal in patients who have had hearing thresholds improved by middle ear surgery. Binaural hearing was assessed at a test frequency of 500 Hz using the masking level difference...
Effect of conductive hearing loss and middle ear surgery on binaural hearing. This study investigated whether conductive hearing loss reduces normal binaural hearing advantages and whether binaural hearing advantages are normal in patients who have had hearing thresholds improved by middle ear surgery. Binaural hearing...
3,767,223
pubmed23n0125_13851
Recurrent mixed tumor.
Recurrence of benign neoplasms can usually be attributed to incomplete excision. Such is the case with benign mixed tumors of salivary glands. Certain histopathologic features of mixed tumors, however, appear to facilitate recurrences. These are: a predominantly myxoid composition, and transcapsular extension by the tu...
Recurrent mixed tumor. Recurrence of benign neoplasms can usually be attributed to incomplete excision. Such is the case with benign mixed tumors of salivary glands. Certain histopathologic features of mixed tumors, however, appear to facilitate recurrences. These are: a predominantly myxoid composition, and transcapsu...
3,767,226
pubmed23n0125_13852
Malleus grip prosthesis.
The malleus grip prosthesis is designed for ears with conductive hearing loss caused by pathologic conditions of the stapes in association with pathologic conditions of the malleus or incus. The malleus grip procedure was performed on 220 ears, and follow-up studies are available on 203. Mild to profound sensorineural ...
Malleus grip prosthesis. The malleus grip prosthesis is designed for ears with conductive hearing loss caused by pathologic conditions of the stapes in association with pathologic conditions of the malleus or incus. The malleus grip procedure was performed on 220 ears, and follow-up studies are available on 203. Mild t...
3,767,224
pubmed23n0125_13853
Effect on biochemical values of heat treatment of plasma for the safe handling of samples from AIDS patients.
There is widespread concern amongst laboratory workers over the risks of exposure to human T cell lymphotrophic virus III [HTLV III] and the possibility of the subsequent development of the acquired immune deficiency syndrome [AIDS]. HTLV III is thermolabile and is completely inactivated by heating at 56 degrees C for ...
Effect on biochemical values of heat treatment of plasma for the safe handling of samples from AIDS patients. There is widespread concern amongst laboratory workers over the risks of exposure to human T cell lymphotrophic virus III [HTLV III] and the possibility of the subsequent development of the acquired immune defi...
3,767,248
pubmed23n0125_13854
Whole blood osmolality.
The osmolality of plasma and heparinised whole blood samples collected from hospital patients was estimated using measurement of the depression of freezing point. There was no clinically significant difference between osmolality measurement made on either whole blood, or plasma taken from the same patient. Neither cell...
Whole blood osmolality. The osmolality of plasma and heparinised whole blood samples collected from hospital patients was estimated using measurement of the depression of freezing point. There was no clinically significant difference between osmolality measurement made on either whole blood, or plasma taken from the sa...
3,767,250
pubmed23n0125_13855
Regional quality assessment of pH and blood gas analysers.
The performance of 41 pH and blood gas analysers in 20 hospitals was assessed using commercially available blood gas ampoules provided by seven manufacturers. The stability of the material and the effect of ambient temperature on Po2 was assessed. The overall mean values were outside the manufacturers' assigned values ...
Regional quality assessment of pH and blood gas analysers. The performance of 41 pH and blood gas analysers in 20 hospitals was assessed using commercially available blood gas ampoules provided by seven manufacturers. The stability of the material and the effect of ambient temperature on Po2 was assessed. The overall m...
3,767,252
pubmed23n0125_13856
Radioimmunoassay of buprenorphine with iodine label: analysis of buprenorphine and metabolites in human plasma.
Quantitative analysis of potent opiate drugs in plasma by radioimmunoassay is potentially inaccurate because of the occurrence of cross-reacting metabolites. This paper describes the chemical synthesis of buprenorphine-3-O-glucuronide, a metabolite of buprenorphine, and an extraction procedure coupled with radioimmunoa...
Radioimmunoassay of buprenorphine with iodine label: analysis of buprenorphine and metabolites in human plasma. Quantitative analysis of potent opiate drugs in plasma by radioimmunoassay is potentially inaccurate because of the occurrence of cross-reacting metabolites. This paper describes the chemical synthesis of bup...
3,767,253
pubmed23n0125_13857
Thyroid function tests in patients with familial dysalbuminaemic hyperthyroxinaemia (FDH).
Two patients with familial dysalbuminaemic hyperthyroxinaemia (FDH) are described in whom the albumin variant resulted in raised total T4 levels, and artefactually raised free T4 using a 'single-step' technique employing an analogue of T4 as tracer. The first patient was clinically euthyroid and presented with relapse ...
Thyroid function tests in patients with familial dysalbuminaemic hyperthyroxinaemia (FDH). Two patients with familial dysalbuminaemic hyperthyroxinaemia (FDH) are described in whom the albumin variant resulted in raised total T4 levels, and artefactually raised free T4 using a 'single-step' technique employing an analo...
3,767,254
pubmed23n0125_13858
Drug screening: evaluation of the Toxi-Lab TLC system.
An evaluation of a commercial TLC Kit System (Toxi-Lab) is described. The performance of the system is assessed in the detection of drugs in overdose and in therapy, and is compared with a GC drug screening system. Toxi-Lab performed well in investigating drug overdoses. We found data on metabolite patterns essential f...
Drug screening: evaluation of the Toxi-Lab TLC system. An evaluation of a commercial TLC Kit System (Toxi-Lab) is described. The performance of the system is assessed in the detection of drugs in overdose and in therapy, and is compared with a GC drug screening system. Toxi-Lab performed well in investigating drug over...
3,767,255
pubmed23n0125_13859
Glycosylated haemoglobin: comparison of five different methods, including measurement on capillary blood samples.
Glycosylated haemoglobin was measured in venous blood samples and in blood collected in 'Unistep' bottles by isoelectric focusing (IEF), as the reference method, and by electroendosmosis (EEO), the thiobarbituric acid method (TBA), ion-exchange chromatography (IEC) and affinity chromatography (AC). Isoelectric focusing...
Glycosylated haemoglobin: comparison of five different methods, including measurement on capillary blood samples. Glycosylated haemoglobin was measured in venous blood samples and in blood collected in 'Unistep' bottles by isoelectric focusing (IEF), as the reference method, and by electroendosmosis (EEO), the thiobarb...
3,767,256
pubmed23n0125_13860
An examination of the hexokinase method for serum glucose assay using external quality assessment data.
Hexokinase methods for serum glucose assay appeared to give slightly but consistently higher inter-laboratory coefficients of variation than all methods combined in the UK External Quality Assessment Scheme; their performance over a two-year period was therefore compared with that for three groups of glucose oxidase me...
An examination of the hexokinase method for serum glucose assay using external quality assessment data. Hexokinase methods for serum glucose assay appeared to give slightly but consistently higher inter-laboratory coefficients of variation than all methods combined in the UK External Quality Assessment Scheme; their pe...
3,767,257
pubmed23n0125_13861
Determination of aluminium in human tissues by flameless atomic absorption spectroscopy and comparison of reference values.
Aluminium in human tissues has been determined by flameless atomic absorption spectroscopy (AAS). Tissues were dried at 110 degrees C and digested with concentrated nitric acid at 50 degrees C overnight. After dilution with distilled water the samples were measured. The aluminium levels of the controls (healthy individ...
Determination of aluminium in human tissues by flameless atomic absorption spectroscopy and comparison of reference values. Aluminium in human tissues has been determined by flameless atomic absorption spectroscopy (AAS). Tissues were dried at 110 degrees C and digested with concentrated nitric acid at 50 degrees C ove...
3,767,258
pubmed23n0125_13862
Testosterone assays: guidelines for the provision of a clinical biochemistry service.
Approximately one year after the devolution of testosterone assays from the SAS, the Analytical Methods Working Party of the Association of Clinical Biochemists set up a working party to investigate the performance of the assays, to survey the available methodology and to give guidance on the factors that influence the...
Testosterone assays: guidelines for the provision of a clinical biochemistry service. Approximately one year after the devolution of testosterone assays from the SAS, the Analytical Methods Working Party of the Association of Clinical Biochemists set up a working party to investigate the performance of the assays, to s...
3,767,259
pubmed23n0125_13863
Acceptance of values assigned to serum-based calibration materials.
A questionnaire sent to laboratories in the UK and Ireland elicited information on acceptance or otherwise of values assigned to serum-based calibration materials for 14 analytes. Overall, 33% of assigned values were changed by users. The reasons for change, together with the degree of magnitude and direction of change...
Acceptance of values assigned to serum-based calibration materials. A questionnaire sent to laboratories in the UK and Ireland elicited information on acceptance or otherwise of values assigned to serum-based calibration materials for 14 analytes. Overall, 33% of assigned values were changed by users. The reasons for c...
3,767,261
pubmed23n0125_13864
Changes in sample isoferritin composition as a possible cause of dilutional discrepancies in ferritin 2-site immunoradiometric assay results.
The effect of changes in sample isoferritin composition on the behaviour of ferritin 2-site immunoradiometric assays was investigated using a computer model and experimental studies. Modelling studies predicted that under conditions where a sample has a different isoferritin composition from the assay standards, progre...
Changes in sample isoferritin composition as a possible cause of dilutional discrepancies in ferritin 2-site immunoradiometric assay results. The effect of changes in sample isoferritin composition on the behaviour of ferritin 2-site immunoradiometric assays was investigated using a computer model and experimental stud...
3,767,263
pubmed23n0125_13865
A fluorimetric method for measurement of erythrocyte transketolase activity.
A method for measuring erythrocyte transketolase activity (ETKA) is described that is precise, economical of reagents and capable of high throughput with partial or full automation. The transketolase-dependent transformation of ribose-5-phosphate, yielding glyceraldehyde-3-phosphate, is linked via 'indicator enzymes' t...
A fluorimetric method for measurement of erythrocyte transketolase activity. A method for measuring erythrocyte transketolase activity (ETKA) is described that is precise, economical of reagents and capable of high throughput with partial or full automation. The transketolase-dependent transformation of ribose-5-phosph...
3,767,264
pubmed23n0125_13866
Reduced serum carnosinase activity in hypothyroidism.
Carnosinase hydrolyses carnosine in muscle, and its deficiency is associated with extensive neuromuscular abnormalities. We measured serum carnosinase activity in patients with thyroid dysfunction which often involves neuromuscular systems. In hyperthyroidism, the carnosinase activity was not significantly different fr...
Reduced serum carnosinase activity in hypothyroidism. Carnosinase hydrolyses carnosine in muscle, and its deficiency is associated with extensive neuromuscular abnormalities. We measured serum carnosinase activity in patients with thyroid dysfunction which often involves neuromuscular systems. In hyperthyroidism, the c...
3,767,265
pubmed23n0125_13867
Screening for early diabetic nephropathy.
An albumin excretion rate of 30-150 micrograms/min is a strong predictor of future clinical diabetic nephropathy. The collection of urine samples commonly used is cumbersome and tedious for both patients and laboratory staff. We have therefore examined the usefulness of albumin:creatinine ratio measurement as a predict...
Screening for early diabetic nephropathy. An albumin excretion rate of 30-150 micrograms/min is a strong predictor of future clinical diabetic nephropathy. The collection of urine samples commonly used is cumbersome and tedious for both patients and laboratory staff. We have therefore examined the usefulness of albumin...
3,767,266
pubmed23n0125_13868
Glycosylated plasma protein measurement by a semi-automated method.
A semi-automated method for determination of glycosylation of plasma proteins using the thiobarbituric acid method is described. Plasma samples (100 microL) and a plasma pool used as a secondary standard were incubated in 0.3 M oxalic acid at 100 degrees C for exactly 2 h. The hydroxymethyl furfural released and the to...
Glycosylated plasma protein measurement by a semi-automated method. A semi-automated method for determination of glycosylation of plasma proteins using the thiobarbituric acid method is described. Plasma samples (100 microL) and a plasma pool used as a secondary standard were incubated in 0.3 M oxalic acid at 100 degre...
3,767,267
pubmed23n0125_13869
Glycosylated haemoglobin by affinity chromatography in diabetic and non-diabetic children.
We have made an evaluation of glycosylated haemoglobin measurements by affinity chromatography in a paediatric population. Age-related reference values for non-diabetic infants and children are reported. A poor correlation (r = 0.24) was found between glycosylated haemoglobin values in 26 insulin-dependent diabetic chi...
Glycosylated haemoglobin by affinity chromatography in diabetic and non-diabetic children. We have made an evaluation of glycosylated haemoglobin measurements by affinity chromatography in a paediatric population. Age-related reference values for non-diabetic infants and children are reported. A poor correlation (r = 0...
3,767,270
pubmed23n0125_13870
Comparison of three parathyroid hormone assays.
The efficiency of three parathyroid hormone (PTH) assays in the diagnosis of primary hyperparathyroidism has been investigated. Two assays used commercial reagents and measured the intact hormone and middle region of parathyroid hormone and the third assay employed the antiserum AS 211/32. Although the intact and mid-m...
Comparison of three parathyroid hormone assays. The efficiency of three parathyroid hormone (PTH) assays in the diagnosis of primary hyperparathyroidism has been investigated. Two assays used commercial reagents and measured the intact hormone and middle region of parathyroid hormone and the third assay employed the an...
3,767,271
pubmed23n0125_13871
Performance and clinical utility of a commercially available 'C-terminal' PTH assay.
The performance and clinical utility of a 'C-terminal' parathyroid hormone (PTH) radioimmunoassay (Dac-Cel, Wellcome Diagnostics) is described. Parathyroid hormone, as measured by the Dac-Cel method, is stable in whole blood samples for at least 24 h. 84% of patients with hypercalcaemia due to primary hyperparathyroidi...
Performance and clinical utility of a commercially available 'C-terminal' PTH assay. The performance and clinical utility of a 'C-terminal' parathyroid hormone (PTH) radioimmunoassay (Dac-Cel, Wellcome Diagnostics) is described. Parathyroid hormone, as measured by the Dac-Cel method, is stable in whole blood samples fo...
3,767,272
pubmed23n0125_13872
The effect of hydropenia and oral water loading on renal lysozyme handling and N-acetyl-beta-D-glucosaminidase excretion in man.
To substantiate the effects of urine flow rate on renal lysozyme handling and N-acetyl-beta-D-glucosaminidase (NAG) excretion, experiments were performed in normal human subjects. Urine flow rate was varied by overnight fluid deprivation and progressive diuresis induced by oral water loading. Lysozyme measurements were...
The effect of hydropenia and oral water loading on renal lysozyme handling and N-acetyl-beta-D-glucosaminidase excretion in man. To substantiate the effects of urine flow rate on renal lysozyme handling and N-acetyl-beta-D-glucosaminidase (NAG) excretion, experiments were performed in normal human subjects. Urine flow ...
3,767,273
pubmed23n0125_13873
Effect of ethanol on erythrocyte acetylcholinesterase activity.
Erythrocyte acetylcholinesterase (AchE) activity was measured in the blood of 36 alcoholic subjects and 41 healthy volunteers. The mean activity in the alcoholics was significantly lower than that in the control subjects. In vitro experiments showed that ethanol inhibited the AchE activity immediately and in proportion...
Effect of ethanol on erythrocyte acetylcholinesterase activity. Erythrocyte acetylcholinesterase (AchE) activity was measured in the blood of 36 alcoholic subjects and 41 healthy volunteers. The mean activity in the alcoholics was significantly lower than that in the control subjects. In vitro experiments showed that e...
3,767,274
pubmed23n0125_13874
The blunder-rate in a clinical biochemistry service.
We describe a study undertaken to investigate the frequency and type of mistake detected in a large biochemistry laboratory. Blunders were recorded over three non-consecutive 3-week periods. The returns to the external quality assessment schemes during a 12-month period were also monitored. Despite changes in laborator...
The blunder-rate in a clinical biochemistry service. We describe a study undertaken to investigate the frequency and type of mistake detected in a large biochemistry laboratory. Blunders were recorded over three non-consecutive 3-week periods. The returns to the external quality assessment schemes during a 12-month per...
3,767,275
pubmed23n0125_13875
Long-term trends in biochemical data obtained from two population surveys.
A study has been made of the variations in monthly mean values of 10 serum constituents in subjects participating in two partly-concurrent long-term epidemiological surveys. Closely similar patterns of variation were found in men in both surveys and in men and women in one survey. During the 6 years of the study, four ...
Long-term trends in biochemical data obtained from two population surveys. A study has been made of the variations in monthly mean values of 10 serum constituents in subjects participating in two partly-concurrent long-term epidemiological surveys. Closely similar patterns of variation were found in men in both surveys...
3,767,276
pubmed23n0125_13876
A simple method for the measurement of glycerol in serum.
An automated enzymic assay for the measurement of glycerol in serum is described. As it uses a centrifugal analyser, this method does not require prior extraction. It is precise, sensitive, and can be performed rapidly at low cost.
A simple method for the measurement of glycerol in serum. An automated enzymic assay for the measurement of glycerol in serum is described. As it uses a centrifugal analyser, this method does not require prior extraction. It is precise, sensitive, and can be performed rapidly at low cost.
3,767,278