OTAR3088/CellFinder-all · Data Studio · Datasets at Hugging Face

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However, when confluent cells were maintained in culture in the presence or absence of 5-AzaC without passage for more than 21 d, expression of specific skeletal muscle markers such as MyoD and fast-switch myosin was observed (Figure 3A).	[ { "end": 168, "label": "Tissue", "start": 162 }, { "end": 161, "label": "Tissue", "start": 153 }, { "end": 168, "label": "Tissue", "start": 153 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
More rapid myogenic differentiation was obtained in the presence of 24-h-conditioned medium from the murine myoblastic cell line C2C12 previously induced to form myotubes [14].	[ { "end": 170, "label": "CellType", "start": 162 }, { "end": 170, "label": "CellType", "start": 162 }, { "end": 19, "label": "Tissue", "start": 11 }, { "end": 134, "label": "CellLine", "start": 129 }, { "end": 123, "label": "CellType", "star...	15971941	[ { "tags": [ "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellType", "I-CellType", "I-CellType", "O", "B-CellLine", "O", "O", "O", "O", ...
Direct coculture of hESMPCs with C2C12 cells led to the formation of hESMPC-derived myotubes, as visualized by expression of human nuclear antigen (Figure 3B), similar to those formed by host C2C12 cells.	[ { "end": 203, "label": "CellType", "start": 192 }, { "end": 44, "label": "CellType", "start": 33 }, { "end": 203, "label": "CellType", "start": 192 }, { "end": 92, "label": "CellType", "start": 84 }, { "end": 27, "label": "CellType", "start...	15971941	[ { "tags": [ "O", "O", "O", "B-CellType", "O", "B-CellType", "I-CellType", "O", "O", "O", "O", "O", "O", "B-CellType", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
After 1 wk of coculture, myotubes composed of human nuclei accounted for more than 10% of the total number of human cells present, and each human myotube was composed of up to ten human nuclei.	[ { "end": 153, "label": "CellType", "start": 140 }, { "end": 33, "label": "CellType", "start": 25 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellType", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
Human cell contribution to myotubes in coculture was confirmed by expression of human muscle-specific transcripts such as MyoD, myosin heavy chain IIa, and myogenin (data not shown).	[ { "end": 92, "label": "Tissue", "start": 86 }, { "end": 35, "label": "CellType", "start": 27 }, { "end": 92, "label": "Tissue", "start": 86 }, { "end": 35, "label": "CellType", "start": 27 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "B-CellType", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
These data demonstrate that hESMPCs can give rise to mesenchymal derivatives typically obtained from primary adult MSCs, as well as to cells expressing markers of skeletal muscle.	[ { "end": 76, "label": "CellType", "start": 53 }, { "end": 171, "label": "Tissue", "start": 163 }, { "end": 64, "label": "Tissue", "start": 53 }, { "end": 178, "label": "Tissue", "start": 172 }, { "end": 119, "label": "CellType", "start": 11...	15971941	[ { "tags": [ "O", "O", "O", "O", "B-CellType", "O", "O", "O", "O", "B-CellType", "I-CellType", "O", "O", "O", "O", "O", "B-CellType", "O", "O", "O", "O", "O", "O", "O", ...
One concern for the clinical application of hESC-derived progeny in regenerative medicine is the risk of teratoma formation due to the presence of residual undifferentiated ES cells among the differentiated progeny.	[ { "end": 214, "label": "CellType", "start": 207 }, { "end": 181, "label": "CellType", "start": 173 }, { "end": 64, "label": "CellType", "start": 57 }, { "end": 113, "label": "Tissue", "start": 105 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellType", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "B-...
We did not detect markers of undifferentiated hESCs, such as Nanog [15] or Oct-4 [16], in any of the hESMPCs by RT-PCR (see Figure 2D) and immunocytochemistry (data not shown), suggesting the lack of any undifferentiated ES cells in hESMPC cultures.	[ { "end": 51, "label": "CellType", "start": 46 }, { "end": 108, "label": "CellType", "start": 101 }, { "end": 229, "label": "CellType", "start": 221 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellType", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellTyp...
However, future in vivo studies are required to rule out the potential of these cells for teratoma formation.	[ { "end": 98, "label": "Tissue", "start": 90 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O" ], "tokens": [ "However", ",", "future", "...
Previous studies have demonstrated the derivation of neural cells [1–3], hematopoietic [17] and endothelial lineages [18], and cardiomyocytes [19] from hESCs.	[ { "end": 142, "label": "CellType", "start": 128 }, { "end": 66, "label": "CellType", "start": 54 }, { "end": 108, "label": "Tissue", "start": 97 }, { "end": 87, "label": "Tissue", "start": 74 }, { "end": 158, "label": "CellType", "start": 1...	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "I-CellType", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
This study presents the induction of paraxial mesoderm with the generation of multipotent mesenchymal precursors.	[ { "end": 112, "label": "CellType", "start": 102 }, { "end": 112, "label": "CellType", "start": 90 }, { "end": 45, "label": "Tissue", "start": 37 }, { "end": 54, "label": "Tissue", "start": 37 }, { "end": 54, "label": "Tissue", "start": 46 ...	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "B-CellType", "I-CellType", "O" ], "tokens": [ "This", "study", "presents", "the", "ind...
We calculate that under these conditions a single undifferentiated hESC yields an average of one CD73+ cell at day 40 of differentiation, suggesting a balance between cell proliferation and cell selection.	[ { "end": 106, "label": "CellType", "start": 97 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellType", "I-CellType", "O", "O", "O", "O", "O", "O", "O", "O", "...
There were no obvious differences in marker and gene-expression profile or in differentiation behavior among the five hESMPC lines generated.	[]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "no", ...
However, some of the lines (e.g., hESMPC9.1) exhibited a tendency of spontaneous osteogenic differentiation after long-term propagation.	[ { "end": 43, "label": "CellLine", "start": 34 }, { "end": 91, "label": "Tissue", "start": 81 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O" ], "tokens": [ "However", ...
Directed differentiation of hESCs into somatic stem-cell-like precursors represents a substantial advancement in harnessing the developmental potential of hESCs.	[ { "end": 72, "label": "CellType", "start": 39 }, { "end": 160, "label": "CellType", "start": 155 }, { "end": 72, "label": "CellType", "start": 62 }, { "end": 56, "label": "CellType", "start": 47 }, { "end": 33, "label": "CellType", "start":...	15971941	[ { "tags": [ "O", "O", "O", "B-CellType", "O", "B-CellType", "I-CellType", "I-CellType", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellType", "O" ], "tokens": [ "Direct...
The high purity, unlimited availability, and multipotentiality of hESMPCs will provide the basis for future therapeutic efforts using these cells in preclinical animal models of disease.	[ { "end": 73, "label": "CellType", "start": 66 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellType", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
Such in vivo studies will also be required to properly assess the safety profile of these cells.	[]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "in", "vivo", "studies", "will", "al...
Furthermore, our system also offers a novel platform to study basic mechanisms of mesodermal induction and differentiation during early human development.	[ { "end": 92, "label": "Tissue", "start": 82 } ]	15971941	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore...
	[]	15971941	[ { "tags": [], "tokens": [] } ]

However, when confluent cells were maintained in culture in the presence or absence of 5-AzaC without passage for more than 21 d, expression of specific skeletal muscle markers such as MyoD and fast-switch myosin was observed (Figure 3A).

[ { "end": 168, "label": "Tissue", "start": 162 }, { "end": 161, "label": "Tissue", "start": 153 }, { "end": 168, "label": "Tissue", "start": 153 } ]

15971941

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More rapid myogenic differentiation was obtained in the presence of 24-h-conditioned medium from the murine myoblastic cell line C2C12 previously induced to form myotubes [14].

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15971941

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Direct coculture of hESMPCs with C2C12 cells led to the formation of hESMPC-derived myotubes, as visualized by expression of human nuclear antigen (Figure 3B), similar to those formed by host C2C12 cells.

[ { "end": 203, "label": "CellType", "start": 192 }, { "end": 44, "label": "CellType", "start": 33 }, { "end": 203, "label": "CellType", "start": 192 }, { "end": 92, "label": "CellType", "start": 84 }, { "end": 27, "label": "CellType", "start...

15971941

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After 1 wk of coculture, myotubes composed of human nuclei accounted for more than 10% of the total number of human cells present, and each human myotube was composed of up to ten human nuclei.

[ { "end": 153, "label": "CellType", "start": 140 }, { "end": 33, "label": "CellType", "start": 25 } ]

15971941

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Human cell contribution to myotubes in coculture was confirmed by expression of human muscle-specific transcripts such as MyoD, myosin heavy chain IIa, and myogenin (data not shown).

[ { "end": 92, "label": "Tissue", "start": 86 }, { "end": 35, "label": "CellType", "start": 27 }, { "end": 92, "label": "Tissue", "start": 86 }, { "end": 35, "label": "CellType", "start": 27 } ]

15971941

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These data demonstrate that hESMPCs can give rise to mesenchymal derivatives typically obtained from primary adult MSCs, as well as to cells expressing markers of skeletal muscle.

[ { "end": 76, "label": "CellType", "start": 53 }, { "end": 171, "label": "Tissue", "start": 163 }, { "end": 64, "label": "Tissue", "start": 53 }, { "end": 178, "label": "Tissue", "start": 172 }, { "end": 119, "label": "CellType", "start": 11...

15971941

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One concern for the clinical application of hESC-derived progeny in regenerative medicine is the risk of teratoma formation due to the presence of residual undifferentiated ES cells among the differentiated progeny.

[ { "end": 214, "label": "CellType", "start": 207 }, { "end": 181, "label": "CellType", "start": 173 }, { "end": 64, "label": "CellType", "start": 57 }, { "end": 113, "label": "Tissue", "start": 105 } ]

15971941

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We did not detect markers of undifferentiated hESCs, such as Nanog [15] or Oct-4 [16], in any of the hESMPCs by RT-PCR (see Figure 2D) and immunocytochemistry (data not shown), suggesting the lack of any undifferentiated ES cells in hESMPC cultures.

[ { "end": 51, "label": "CellType", "start": 46 }, { "end": 108, "label": "CellType", "start": 101 }, { "end": 229, "label": "CellType", "start": 221 } ]

15971941

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However, future in vivo studies are required to rule out the potential of these cells for teratoma formation.

[ { "end": 98, "label": "Tissue", "start": 90 } ]

15971941

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O" ], "tokens": [ "However", ",", "future", "...

Previous studies have demonstrated the derivation of neural cells [1–3], hematopoietic [17] and endothelial lineages [18], and cardiomyocytes [19] from hESCs.

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15971941

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This study presents the induction of paraxial mesoderm with the generation of multipotent mesenchymal precursors.

[ { "end": 112, "label": "CellType", "start": 102 }, { "end": 112, "label": "CellType", "start": 90 }, { "end": 45, "label": "Tissue", "start": 37 }, { "end": 54, "label": "Tissue", "start": 37 }, { "end": 54, "label": "Tissue", "start": 46 ...

15971941

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We calculate that under these conditions a single undifferentiated hESC yields an average of one CD73+ cell at day 40 of differentiation, suggesting a balance between cell proliferation and cell selection.

[ { "end": 106, "label": "CellType", "start": 97 } ]

15971941

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There were no obvious differences in marker and gene-expression profile or in differentiation behavior among the five hESMPC lines generated.

[]

15971941

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "no", ...

However, some of the lines (e.g., hESMPC9.1) exhibited a tendency of spontaneous osteogenic differentiation after long-term propagation.

[ { "end": 43, "label": "CellLine", "start": 34 }, { "end": 91, "label": "Tissue", "start": 81 } ]

15971941

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O" ], "tokens": [ "However", ...

Directed differentiation of hESCs into somatic stem-cell-like precursors represents a substantial advancement in harnessing the developmental potential of hESCs.

[ { "end": 72, "label": "CellType", "start": 39 }, { "end": 160, "label": "CellType", "start": 155 }, { "end": 72, "label": "CellType", "start": 62 }, { "end": 56, "label": "CellType", "start": 47 }, { "end": 33, "label": "CellType", "start":...

15971941

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The high purity, unlimited availability, and multipotentiality of hESMPCs will provide the basis for future therapeutic efforts using these cells in preclinical animal models of disease.

[ { "end": 73, "label": "CellType", "start": 66 } ]

15971941

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Such in vivo studies will also be required to properly assess the safety profile of these cells.

[]

15971941

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Furthermore, our system also offers a novel platform to study basic mechanisms of mesodermal induction and differentiation during early human development.

[ { "end": 92, "label": "Tissue", "start": 82 } ]

15971941

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[]

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