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pmcid large_stringlengths 8 11 | pmid large_stringlengths 0 9 | authors large_stringlengths 0 33.4k | title large_stringlengths 0 2.49k | publication_date large_stringlengths 10 10 | keywords large_stringlengths 0 17k | abstract large_stringlengths 0 122k | text large_stringlengths 9 8.39M |
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PMC10000013 | Sayan Chatterjee,Lakshmi Vineela Nalla,Monika Sharma,Nishant Sharma,Aditya A. Singh,Fehmina Mushtaque Malim,Manasi Ghatage,Mohd Mukarram,Abhijeet Pawar,Nidhi Parihar,Neha Arya,Amit Khairnar | Association of COVID-19 with Comorbidities: An Update | 27-02-2023 | COVID-19,comorbidity,diabetes,cancer,Parkinson’s disease,cardiovascular disease | Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) which was identified in Wuhan, China in December 2019 and jeopardized human lives. It spreads at an unprecedented rate worldwide, with serious and still-unfolding health conditions and economic ramifications. Based ... | Association of COVID-19 with Comorbidities: An Update
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) which was identified in Wuhan, China in December 2019 and jeopardized human lives. It spreads at an unprecedented rate worldwide, with serious and still-unfoldi... | |
PMC10000025 | Qi Min,Lu Yang,Yu Wang,Yili Liu,Mingfeng Jiang | Transcriptome-Based Evaluation of Optimal Reference Genes for Quantitative Real-Time PCR in Yak Stomach throughout the Growth Cycle | 03-03-2023 | yak,stomach,transcriptome-wide,reference gene,RT-qPCR | Simple Summary The stomach is one of the primary sites for the digestion and absorption of nutrients. Quantifying related gene expression patterns using quantitative real-time PCR (RT-qPCR) is conducive to further understanding the molecular mechanisms underlying nutrition metabolism in the yak stomach. The authenticit... | Transcriptome-Based Evaluation of Optimal Reference Genes for Quantitative Real-Time PCR in Yak Stomach throughout the Growth Cycle
The stomach is one of the primary sites for the digestion and absorption of nutrients. Quantifying related gene expression patterns using quantitative real-time PCR (RT-qPCR) is conducive... | |
PMC10000032 | Maria Brockmann,Christoph Leineweber,Tom Hellebuyck,An Martel,Frank Pasmans,Michaela Gentil,Elisabeth Müller,Rachel E. Marschang | Establishment of a Real-Time PCR Assay for the Detection of Devriesea agamarum in Lizards | 28-02-2023 | Devriesea agamarum,polymerase chain reaction,Uromastyx sp.,Pogona vitticeps,bearded dragon,lizard,reptile,cheilitis,dermatitis | Simple Summary Bacterial infections can play an important role in dermatitis in lizards. The bacterial species Devriesea (D.) agamarum is a known cause of dermatitis, cheilitis and even fatal disease in lizards. Disease has most often been reported in Uromastyx species, but other lizards may also be affected. However, ... | Establishment of a Real-Time PCR Assay for the Detection of Devriesea agamarum in Lizards
Bacterial infections can play an important role in dermatitis in lizards. The bacterial species Devriesea (D.) agamarum is a known cause of dermatitis, cheilitis and even fatal disease in lizards. Disease has most often been repo... | |
PMC10000039 | Neelam A. Topno,Veerbhan Kesarwani,Sandeep Kumar Kushwaha,Sarwar Azam,Mohammad Kadivella,Ravi Kumar Gandham,Subeer S. Majumdar | Non-Synonymous Variants in Fat QTL Genes among High- and Low-Milk-Yielding Indigenous Breeds | 28-02-2023 | milk fat,whole-genome sequencing,SNPs,genomic variation,variant calling,indigenous breeds | Highlights What are the main findings? Differentially expressed milk fat QTL genes explored with whole genome se-quencing for variant analysis. Identified non-synonymous SNPs for hub and bottleneck QTL genes associated with milk fat traits. What is the implication of the main finding? Identified differential pattern(s)... | Non-Synonymous Variants in Fat QTL Genes among High- and Low-Milk-Yielding Indigenous Breeds
What are the main findings? Differentially expressed milk fat QTL genes explored with whole genome se-quencing for variant analysis. Identified non-synonymous SNPs for hub and bottleneck QTL genes associated with milk fat trai... | |
PMC10000040 | Yue Sun,Yanze Yu,Jinhao Guo,Linqiang Zhong,Minghai Zhang | Alterations in Fecal Microbiota Linked to Environment and Sex in Red Deer (Cervus elaphus) | 04-03-2023 | cervidae,KEGG,fecal microbiota,16s rRNA | Simple Summary The gut microbiota forms a complex microecosystem in vertebrates and is affected by various factors. Wild and captive red deer currently live in the same region but have vastly different diets. In this study, the 16S rRNA sequencing technology was performed to evaluate variations in the fecal microbiota ... | Alterations in Fecal Microbiota Linked to Environment and Sex in Red Deer (Cervus elaphus)
The gut microbiota forms a complex microecosystem in vertebrates and is affected by various factors. Wild and captive red deer currently live in the same region but have vastly different diets. In this study, the 16S rRNA sequen... | |
PMC10000043 | Asmaa Sadat,Alshimaa M. M. Farag,Driss Elhanafi,Amal Awad,Ehab Kotb Elmahallawy,Noorah Alsowayeh,Manal F. El-khadragy,Gehad E. Elshopakey | Immunological and Oxidative Biomarkers in Bovine Serum from Healthy, Clinical, and Sub-Clinical Mastitis Caused by Escherichia coli and Staphylococcus aureus Infection | 01-03-2023 | mastitis,E. coli,S. aureus,oxidative/antioxidant molecules,APP,inflammatory cytokines | Simple Summary Establishing reliable biomarkers of udder bacterial infection and its bovine immune response at the early stage of the mastitic infection is considered an urgent matter. Thus, reliable biomarkers were measured in our study for accurate detection of the changes in biochemical and immunological parameters ... | Immunological and Oxidative Biomarkers in Bovine Serum from Healthy, Clinical, and Sub-Clinical Mastitis Caused by Escherichia coli and Staphylococcus aureus Infection
Establishing reliable biomarkers of udder bacterial infection and its bovine immune response at the early stage of the mastitic infection is considered... | |
PMC10000048 | Duy Ngoc Do,Prashanth Suravajhala | Editorial: Role of Non-Coding RNAs in Animals | 23-02-2023 | Editorial: Role of Non-Coding RNAs in Animals
The importance of non-coding RNAs (ncRNAs), such as microRNAs (miRNA), long non-coding RNAs (lncRNA), and circular RNAs (circRNA), in gene regulation is increasingly being appreciated in many species. Thanks to the next generation of sequencing methods, thousands of ncRNAs... | |||
PMC10000050 | Rosa Marchetti,Valerio Faeti,Maurizio Gallo,Massimo Pindo,Davide Bochicchio,Luca Buttazzoni,Giacinto Della Casa | Protein Content in the Diet Influences Growth and Diarrhea in Weaning Piglets | 22-02-2023 | piglet,post-weaning diarrhea,dietary protein,fecal microbiota,feces composition | Simple Summary Weaning (that is, removal from the sow) and the following two months are the riskiest periods in a pig’s life, especially for pig’s gastrointestinal health. The change in diet due to the suspension of the mother’s milk, accompanied by an acceleration of both morphological and enzymatic maturation of the ... | Protein Content in the Diet Influences Growth and Diarrhea in Weaning Piglets
Weaning (that is, removal from the sow) and the following two months are the riskiest periods in a pig’s life, especially for pig’s gastrointestinal health. The change in diet due to the suspension of the mother’s milk, accompanied by an acc... | |
PMC10000055 | Xin Yang,Xuemei Wu,Shuang Huang,Qian Yao,Xi Chen,Junke Song,Yingying Fan,Guanghui Zhao | C3a/C3aR Affects the Propagation of Cryptosporidium parvum in the Ileum Tissues of Mice by Regulating the Gut Barrier, Cell Proliferation, and CD4+ T Cell Main Effectors | 24-02-2023 | Cryptosporidium parvum,C3a/C3aR signaling,propagation,intestinal barrier function,cell proliferation,CD4+ T cell-related cytokines | Simple Summary The complement system plays important roles in both innate and adaptive immunity. The present study explored the function of host C3a/C3aR signaling during Cryptosporidium parvum infection, and found that the C3a/C3aR signaling likely affected the propagation of C. parvum in mouse ileum tissues by regula... | C3a/C3aR Affects the Propagation of Cryptosporidium parvum in the Ileum Tissues of Mice by Regulating the Gut Barrier, Cell Proliferation, and CD4+ T Cell Main Effectors
The complement system plays important roles in both innate and adaptive immunity. The present study explored the function of host C3a/C3aR signaling ... | |
PMC10000059 | Maria Irene Pacini,Maurizio Mazzei,Micaela Sgorbini,Rossella D’Alfonso,Roberto Amerigo Papini | A One-Year Retrospective Analysis of Viral and Parasitological Agents in Wildlife Animals Admitted to a First Aid Hospital | 04-03-2023 | wildlife,central Italy,viruses,helminths,protozoa,interspecies transmission,zoonotic pathogen | Simple Summary In recent decades, wildlife populations in Italy have continued to expand, and some species are now present in large numbers with a wide geographical distribution. Viral and parasitic agents are an integral part of any wildlife population. The major changes in human land use, the tendency of some wild an... | A One-Year Retrospective Analysis of Viral and Parasitological Agents in Wildlife Animals Admitted to a First Aid Hospital
In recent decades, wildlife populations in Italy have continued to expand, and some species are now present in large numbers with a wide geographical distribution. Viral and parasitic agents are a... | |
PMC10000066 | Yansheng Guo,Feifei Wang,Yongxia Mao,Weiyi Kong,Jiandong Wang,Guijie Zhang | Influence of Parturition on Rumen Bacteria and SCFAs in Holstein Cows Based on 16S rRNA Sequencing and Targeted Metabolomics | 21-02-2023 | parturition,dairy cows,rumen bacterial communities,short-chain fatty acids | Simple Summary The depressed appetite at parturition might induce the changes in the composition and quantity of rumen microbiota. At present, little is known about the influence of parturition on the levels of rumen microbiota and their fermentation ability in dairy cows. The objective of this study was to evaluate th... | Influence of Parturition on Rumen Bacteria and SCFAs in Holstein Cows Based on 16S rRNA Sequencing and Targeted Metabolomics
The depressed appetite at parturition might induce the changes in the composition and quantity of rumen microbiota. At present, little is known about the influence of parturition on the levels o... | |
PMC10000067 | Yang Liu,Xiaomin Wang,Xiaoping Luo,Rui Wang,Bintao Zhai,Penglong Wang,Junyan Li,Xiaoye Yang | Transcriptomics and Proteomics of Haemonchus contortus in Response to Ivermectin Treatment | 03-03-2023 | ivermectin,Haemonchus contortus,transcriptomics,proteomics | Simple Summary Haemonchus contortus has a serious impact on the gastrointestinal health of ruminants and the economic sustainable development of animal husbandry. In this study, we examined transcriptomic and proteomic differences in ivermectin-resistant and -susceptible strains of H. contortus before and after Ivermec... | Transcriptomics and Proteomics of Haemonchus contortus in Response to Ivermectin Treatment
Haemonchus contortus has a serious impact on the gastrointestinal health of ruminants and the economic sustainable development of animal husbandry. In this study, we examined transcriptomic and proteomic differences in ivermecti... | |
PMC10000068 | Xuejia Zhai,Ling Mao,Min Wu,Jie Liu,Shicang Yu | Challenges of Anti-Mesothelin CAR-T-Cell Therapy | 21-02-2023 | chimeric antigen receptor T cells (CAR-T cells),mesothelin,clinical trial,solid tumor,immunotherapy | Simple Summary In recent years, chimeric antigen receptor (CAR)-T-cell therapy has achieved good results in hematological malignancies. Clinical trials on anti-MSLN CAR-T cells have shown that they have a high safety profile but limited efficacy. This article reviews the clinical research status, obstacles, progress an... | Challenges of Anti-Mesothelin CAR-T-Cell Therapy
In recent years, chimeric antigen receptor (CAR)-T-cell therapy has achieved good results in hematological malignancies. Clinical trials on anti-MSLN CAR-T cells have shown that they have a high safety profile but limited efficacy. This article reviews the clinical rese... | |
PMC10000071 | I-Ping Yang,Kwan-Ling Yip,Yu-Tang Chang,Yen-Cheng Chen,Ching-Wen Huang,Hsiang-Lin Tsai,Yung-Sung Yeh,Jaw-Yuan Wang | MicroRNAs as Predictive Biomarkers in Patients with Colorectal Cancer Receiving Chemotherapy or Chemoradiotherapy: A Narrative Literature Review | 21-02-2023 | microRNAs,colorectal cancer,chemoresistance,radioresistance,predictive biomarkers | Simple Summary Nearly two decades would be required for a cancer lesion to develop from normal colon mucosa, but most colorectal cancer (CRC) patients are at an advanced stage at presentation. Chemotherapy, targeted therapy, and radiotherapy can improve the prognosis of patients with advanced CRC, but sometimes the the... | MicroRNAs as Predictive Biomarkers in Patients with Colorectal Cancer Receiving Chemotherapy or Chemoradiotherapy: A Narrative Literature Review
Nearly two decades would be required for a cancer lesion to develop from normal colon mucosa, but most colorectal cancer (CRC) patients are at an advanced stage at presentati... | |
PMC10000074 | Xusheng Dong,Xueyan Lin,Qiuling Hou,Zhiyong Hu,Yun Wang,Zhonghua Wang | Effect of Maternal Gradient Nutritional Restriction during Pregnancy on Mammary Gland Development in Offspring | 06-03-2023 | mammary development,nutritional restrictions,pregnancy,offspring | Simple Summary The embryonic period, together with puberty and pregnancy, are known as the three main stages of mammary gland development. The development of the mammary glands is slowed during the embryonic period due to factors such as inadequate nutrition, which directly affect the development of the mammary glands ... | Effect of Maternal Gradient Nutritional Restriction during Pregnancy on Mammary Gland Development in Offspring
The embryonic period, together with puberty and pregnancy, are known as the three main stages of mammary gland development. The development of the mammary glands is slowed during the embryonic period due to f... | |
PMC10000075 | Tessa Bánki,Jarno Drost,Marry M. van den Heuvel-Eibrink,Annelies M. C. Mavinkurve-Groothuis,Ronald R. de Krijger | Somatic, Genetic and Epigenetic Changes in Nephrogenic Rests and Their Role in the Transformation to Wilms Tumors, a Systematic Review | 21-02-2023 | nephrogenic rests,nephroblastomatosis,Wilms tumors,genetic changes,epigenetic alterations | Simple Summary We reviewed all studies investigating molecular changes in nephrogenic rests (NR), the presumed precursor lesions of Wilms tumors (WT) being the most frequent malignant childhood renal tumors, between 1990 and 2022. Only 23 studies were found, reporting 119 pairs of NR and corresponding WT, which may all... | Somatic, Genetic and Epigenetic Changes in Nephrogenic Rests and Their Role in the Transformation to Wilms Tumors, a Systematic Review
We reviewed all studies investigating molecular changes in nephrogenic rests (NR), the presumed precursor lesions of Wilms tumors (WT) being the most frequent malignant childhood renal... | |
PMC10000085 | Thomas John Lopdell | Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle | 02-03-2023 | mammary biology,mammogenesis,lactation,lactogenesis,quantitative trait loci | Simple Summary Milk and other dairy products are commonly consumed in many parts of the world. Dairy cattle, having millions of milk trait records, make excellent model species for understanding the genetics controlling the production of milk. This manuscript gives a summary of the current understanding of the genetic ... | Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle
Milk and other dairy products are commonly consumed in many parts of the world. Dairy cattle, having millions of milk trait records, make excellent model species for understanding the genetics controlling the... | |
PMC10000087 | Yan Wang,Wencan Ke,Qiang Lu,Guijie Zhang | Effects of Bacillus coagulans and Lactobacillus plantarum on the Fermentation Characteristics, Microbial Community, and Functional Shifts during Alfalfa Silage Fermentation | 04-03-2023 | alfalfa,Bacillus coagulans,fermentation composition,microbial diversity | Simple Summary Dry matter loss (DM loss) occurs during silage production, with the potential to reach up to 4–20% due to the aerobic respiration. Lower water-soluble carbohydrates (WSC) and a higher buffering capacity can contribute to this; however, the presence of Bacillus can help create an anaerobic environment, wh... | Effects of Bacillus coagulans and Lactobacillus plantarum on the Fermentation Characteristics, Microbial Community, and Functional Shifts during Alfalfa Silage Fermentation
Dry matter loss (DM loss) occurs during silage production, with the potential to reach up to 4–20% due to the aerobic respiration. Lower water-sol... | |
PMC10000092 | Brigkita Venardou,John V. O’Doherty,Marco Garcia-Vaquero,Claire Kiely,Gaurav Rajauria,Mary J. McDonnell,Marion T. Ryan,Torres Sweeney | In Vitro Evaluation of Brown Seaweed Laminaria spp. as a Source of Antibacterial and Prebiotic Extracts That Could Modulate the Gastrointestinal Microbiota of Weaned Pigs | 24-02-2023 | brown macroalgae,bifidogenic,antibacterial,seaweed polysaccharides,weaned pig,gastrointestinal microbiota,batch fermentation | Simple Summary The transition from milk to solid feed in commercial pig-production systems negatively affects gut health, particularly the composition of the residing microbial community. This can subsequently impair pig growth and long-term health. Natural dietary supplements including seaweed extracts have the capaci... | In Vitro Evaluation of Brown Seaweed Laminaria spp. as a Source of Antibacterial and Prebiotic Extracts That Could Modulate the Gastrointestinal Microbiota of Weaned Pigs
The transition from milk to solid feed in commercial pig-production systems negatively affects gut health, particularly the composition of the resid... | |
PMC10000098 | Bruno Stefanon,Michela Cintio,Sandy Sgorlon,Elisa Scarsella,Danilo Licastro,Alfonso Zecconi,Monica Colitti | Regulatory Role of microRNA of Milk Exosomes in Mastitis of Dairy Cows | 24-02-2023 | milk,exosomes,miRNA,mastitis,cow | Simple Summary The microRNA (miRNA) cargos of exosomes isolated from milk were investigated in relation to the healthy conditions of the mammary gland. Samples were collected from a group of cows without mastitis (H), a group at risk of mastitis (ARM), and a group with subclinical mastitis (SCM). The differential expre... | Regulatory Role of microRNA of Milk Exosomes in Mastitis of Dairy Cows
The microRNA (miRNA) cargos of exosomes isolated from milk were investigated in relation to the healthy conditions of the mammary gland. Samples were collected from a group of cows without mastitis (H), a group at risk of mastitis (ARM), and a grou... | |
PMC10000099 | Larissa Cuta,Christoph Georg Baums,Kerstin Cramer,Maxi Harzer,Jutta Hauptmann,Kristin Heenemann,Maria-Elisabeth Krautwald-Junghanns,Ines Stegmaier,Thomas W. Vahlenkamp,Volker Schmidt | An Explorative Study of the Causal Pathogenesis of Green Liver Discoloration in Organically Reared Female Bronze Turkeys (Meleagris gallopavo) Considering the Infectious Risk Factors | 03-03-2023 | Turkey Osteomyelitis Complex,green liver,hemorrhagic enteritis virus,aseptic bone necrosis | Simple Summary Organically raised turkeys investigated in a recent study showed a high prevalence of green liver discoloration. The condition is commonly associated with bone alterations and is potentially caused by opportunistic bacteria. This study was performed to determine possible infectious risk factors and reduc... | An Explorative Study of the Causal Pathogenesis of Green Liver Discoloration in Organically Reared Female Bronze Turkeys (Meleagris gallopavo) Considering the Infectious Risk Factors
Organically raised turkeys investigated in a recent study showed a high prevalence of green liver discoloration. The condition is common... | |
PMC10000107 | Alessandra Iannuzzi,Leopoldo Iannuzzi,Pietro Parma | Molecular Cytogenetics in Domestic Bovids: A Review | 06-03-2023 | animal cytogenetics,cattle,river buffalo,sheep,goat,FISH mapping,PCR | Simple Summary Molecular cytogenetics, and particularly the use of fluorescence in situ hybridization (FISH), has allowed deeper investigation of the chromosomes of domestic animals in order to: (a) create physical maps of specific DNA sequences on chromosome regions; (b) use specific chromosome markers to confirm the ... | Molecular Cytogenetics in Domestic Bovids: A Review
Molecular cytogenetics, and particularly the use of fluorescence in situ hybridization (FISH), has allowed deeper investigation of the chromosomes of domestic animals in order to: (a) create physical maps of specific DNA sequences on chromosome regions; (b) use speci... | |
PMC10000111 | Katarzyna Perz,Sebastian Andrzej Kaczmarek,Sebastian Nowaczewski,Aaron Joell Cowieson,Marcin Hejdysz | The Effect of Exogenous Amylase Supplementation on the Nutritional Value of Pea (Pisum sativum L.) for Broiler Chickens | 23-02-2023 | pea,amylase,nutritional value,digestibility,poultry | Simple Summary Pea (Pisum sativum L.) can be successfully grown and harvested in almost all the climatic zones across the world. Currently, the main protein source that is used in animal nutrition is soybean meal (SBM). Pea seeds are characterized by a relatively high content of crude protein and starch; therefore, the... | The Effect of Exogenous Amylase Supplementation on the Nutritional Value of Pea (Pisum sativum L.) for Broiler Chickens
Pea (Pisum sativum L.) can be successfully grown and harvested in almost all the climatic zones across the world. Currently, the main protein source that is used in animal nutrition is soybean meal (... | |
PMC10000112 | Rafał Osiecki,Mieszko Kozikowski,Beata Sarecka-Hujar,Michał Pyzlak,Jakub Dobruch | Prostate Cancer Morphologies: Cribriform Pattern and Intraductal Carcinoma Relations to Adverse Pathological and Clinical Outcomes—Systematic Review and Meta-Analysis | 21-02-2023 | prostate cancer,cribriform pattern,intraductal carcinoma,meta-analysis,radical prostatectomy | Simple Summary Prostate cancer is one of the most common male cancers. A more accurate disease assessment is needed to better stratify patients’ risks and guide treatment decisions. It has already been studied that some prostate cancer submorphologies are associated with worse outcomes. We performed a systematic review... | Prostate Cancer Morphologies: Cribriform Pattern and Intraductal Carcinoma Relations to Adverse Pathological and Clinical Outcomes—Systematic Review and Meta-Analysis
Prostate cancer is one of the most common male cancers. A more accurate disease assessment is needed to better stratify patients’ risks and guide treatm... | |
PMC10000116 | Alexandra Teixeira,Luís Carreira,Sara Abalde-Cela,Belém Sampaio-Marques,Anabela C. Areias,Paula Ludovico,Lorena Diéguez | Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review | 21-02-2023 | acute myeloid leukemia (AML),measurable residual disease (MRD),microfluidics,surface-enhanced Raman scattering (SERS) | Simple Summary Acute myeloid leukemia is the most common type of leukemia in adults. It is frequently associated with a limited response to conventional therapies that have a high recurrence and mortality rate in the elderly population. Even patients with clinical remission after initial treatment eventually relapse du... | Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review
Acute myeloid leukemia is the most common type of leukemia in adults. It is frequently associated with a limited response to conventional therapies that have a high recurrence and mortality rate in the elderly popu... | |
PMC10000120 | Davide Adriano Santeufemia,Giuseppe Palmieri,Gianmaria Miolo,Maria Colombino,Maria Grazia Doro,Laura Frogheri,Panagiotis Paliogiannis,Giampiero Capobianco,Massimo Madonia,Antonio Cossu,Giovanni Lo Re,Giuseppe Corona | Current Trends in Mucosal Melanomas: An Overview | 21-02-2023 | cancer,mucosal melanomas,diagnosis,prognosis,genetic,metabolism,immunotherapy | Simple Summary This review provides an updated overview about molecular features, clinical advancements and therapeutic directions of the primary mucosal melanoma which represents a rare and heterogeneous malignancy characterized by a poor prognosis. Abstract Primary mucosal melanomas (MMs) are uncommon tumors originat... | Current Trends in Mucosal Melanomas: An Overview
This review provides an updated overview about molecular features, clinical advancements and therapeutic directions of the primary mucosal melanoma which represents a rare and heterogeneous malignancy characterized by a poor prognosis.
Primary mucosal melanomas (MMs) a... | |
PMC10000128 | Ajay Major,Pierluigi Porcu,Bradley M. Haverkos | Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma | 21-02-2023 | extranodal NK/T-cell lymphoma (ENKTL),biomarkers,novel therapies | Simple Summary Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive blood cancer with poor survival rates, particularly for patients with advanced-stage and relapsed disease. Emerging research on the genetic and molecular causes of ENKTL have revealed new potential treatment strategies. In this review, we summarize h... | Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma
Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive blood cancer with poor survival rates, particularly for patients with advanced-stage and relapsed disease. Emerging research on the genetic and molecular causes of ENKTL have revealed new potential treat... | |
PMC10000135 | Xianbo Jia,Yang He,Zhe Kang,Shiyi Chen,Wenqiang Sun,Jie Wang,Songjia Lai | Comparison of Fecal Microbiota Communities between Primiparous and Multiparous Cows during Non-Pregnancy and Pregnancy | 27-02-2023 | cow,pregnancy,primiparous and multiparous,fecal microbiota,16S rRNA sequencing | Simple Summary An imbalance of the gut microbiota composition may lead to several reproductive disorders and physiological diseases during pregnancy. This study investigates the fecal microbiome composition between primiparous and multiparous cows during non-pregnancy and pregnancy to analyze the host-microbial balance... | Comparison of Fecal Microbiota Communities between Primiparous and Multiparous Cows during Non-Pregnancy and Pregnancy
An imbalance of the gut microbiota composition may lead to several reproductive disorders and physiological diseases during pregnancy. This study investigates the fecal microbiome composition between ... | |
PMC10000137 | Fubin Wang,Xiaoyun Wu,Xiaoming Ma,Qi Bao,Qingbo Zheng,Min Chu,Xian Guo,Chunnian Liang,Ping Yan | The Novel Structural Variation in the GHR Gene Is Associated with Growth Traits in Yaks (Bos grunniens) | 26-02-2023 | Bos grunniens,growth hormone receptor (GHR) gene,growth traits,SV 246 bp,candidate molecular marker | Simple Summary Yak is the dominant animal species in China’s plateau regions. The development of the yak industry is conducive to protecting the ecosystem of the Qinghai–Tibet Plateau and promoting local economic development. However, the slow growth and development of yak have seriously affected the development of the... | The Novel Structural Variation in the GHR Gene Is Associated with Growth Traits in Yaks (Bos grunniens)
Yak is the dominant animal species in China’s plateau regions. The development of the yak industry is conducive to protecting the ecosystem of the Qinghai–Tibet Plateau and promoting local economic development. Howe... | |
PMC10000145 | Bo Deng,Jie Wu,Xuan Liu,Qian Ma,Xin Tao,Keke Qi,Xinping Diao,Ziwei Xu | Effects of Extruded Corn with Different Gelatinization Degrees on Feed Preference, Growth Performance, Nutrient Digestibility, and Fecal Microbiota of Weaning Piglets | 03-03-2023 | extrusion,corn gelatinization,choice feeding,palatability,growth rate,fecal microbiota,piglets | Simple Summary This study was conducted to evaluate the effects of extruded corn with different gelatinization degrees on the feed preference, growth performance, nutrient digestibility, and fecal microbiota of weaning piglets. The results showed that extruded corn can improve feed preference, increase growth performan... | Effects of Extruded Corn with Different Gelatinization Degrees on Feed Preference, Growth Performance, Nutrient Digestibility, and Fecal Microbiota of Weaning Piglets
This study was conducted to evaluate the effects of extruded corn with different gelatinization degrees on the feed preference, growth performance, nutr... | |
PMC10000146 | Ying Yao,Wenjia Zhao,Guilin Xiang,Ruiqing Lv,Yanpeng Dong,Honglin Yan,Mingxi Li | Bamboo Plant Part Preference Affects the Nutrients Digestibility and Intestinal Microbiota of Geriatric Giant Pandas | 25-02-2023 | giant panda,bamboo part,aging,microbiome,nutrient digestibility | Simple Summary Bamboo part preference and a panda’s age have been shown to shift the gut microbiota composition of the giant panda, thus eliciting changes in their nutrient utilization capacity. The present study compared the differences in nutrient digestibility and fecal microbiota composition between adult and geria... | Bamboo Plant Part Preference Affects the Nutrients Digestibility and Intestinal Microbiota of Geriatric Giant Pandas
Bamboo part preference and a panda’s age have been shown to shift the gut microbiota composition of the giant panda, thus eliciting changes in their nutrient utilization capacity. The present study comp... | |
PMC10000151 | Susan Lalondrelle,Jen Lee,Rosalind J. Cutts,Isaac Garcia Murillas,Nik Matthews,Nicholas Turner,Kevin Harrington,Katherine Vroobel,Emily Moretti,Shreerang A. Bhide | Predicting Response to Radical Chemoradiotherapy with Circulating HPV DNA (cHPV-DNA) in Locally Advanced Uterine Cervix Cancer | 22-02-2023 | cervical cancer,plasma HPV DNA,response prediction,circulating DNA,next generation sequencing | Simple Summary Cervix cancer is largely (95%) caused by human papilloma virus (HPV). Curative treatment for locally advanced cervical cancer (progressed beyond the cervix) is chemotherapy and radiotherapy (CRT), followed by internal radiation (brachytherapy). In approximately 30% of patients the cancer will return, usu... | Predicting Response to Radical Chemoradiotherapy with Circulating HPV DNA (cHPV-DNA) in Locally Advanced Uterine Cervix Cancer
Cervix cancer is largely (95%) caused by human papilloma virus (HPV). Curative treatment for locally advanced cervical cancer (progressed beyond the cervix) is chemotherapy and radiotherapy (C... | |
PMC10000161 | Vince G. Amoroso,Aishi Zhao,Isabel Vargas,Thomas J. Park | Naked Mole-Rats Demonstrate Profound Tolerance to Low Oxygen, High Carbon Dioxide, and Chemical Pain | 24-02-2023 | naked mole-rat,hypoxia,anoxia,pain,NaV1.7,HIF-1a,VEGF,Substance P,KCC2 | Simple Summary Naked mole-rats live in crowded underground burrows where concentrations of oxygen can be low and concentrations of carbon dioxide can be high. Accordingly, this species is tolerant of low oxygen levels and high carbon dioxide levels, which would be deadly to most surface dwellers. The current article re... | Naked Mole-Rats Demonstrate Profound Tolerance to Low Oxygen, High Carbon Dioxide, and Chemical Pain
Naked mole-rats live in crowded underground burrows where concentrations of oxygen can be low and concentrations of carbon dioxide can be high. Accordingly, this species is tolerant of low oxygen levels and high carbon... | |
PMC10000162 | Feng Cheng,Hui Wang,Lei Zhou,Ganqiu Lan,Hanchun Yang,Lixian Wang,Ligang Wang,Jing Liang | Systematic Identification and Comparison of the Expressed Profiles of Exosomal MiRNAs in Pigs Infected with NADC30-like PRRSV Strain | 28-02-2023 | PRRSV,serum exosome,miRNAs | Simple Summary Exosomes play a unique role in virus infection, antigen presentation, and suppression/promotion of body immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most damaging pathogens in the pig industry. Here, we used the PRRSV NADC30-like CHsx1401 strain to artificially infe... | Systematic Identification and Comparison of the Expressed Profiles of Exosomal MiRNAs in Pigs Infected with NADC30-like PRRSV Strain
Exosomes play a unique role in virus infection, antigen presentation, and suppression/promotion of body immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) is one of th... | |
PMC10000164 | Giovanni De Benedetto,Fabiano Capparucci,Sabrina Natale,Serena Savoca,Kristian Riolo,Claudio Gervasi,Marco Albano,Alessia Giannetto,Gabriella Gaglio,Carmelo Iaria | Morphological and Molecular Identification of Mullet Helminth Parasite Fauna from Ganzirri Lagoon (Sicily, Southern Italy) | 25-02-2023 | Acanthocephalan,trematode,Chelon labrosus,Chelon auratus,Oedalechilus labeo | Simple Summary We investigated the role of mullet as a biological tag to evaluate environmental status, mainly in a specific and circumscribed area, between March and June 2021, by conducting a survey of 150 mullet caught from Ganzirri Lagoon (Messina, Sicily, Italy), in order to describe the helminth fauna. All retrie... | Morphological and Molecular Identification of Mullet Helminth Parasite Fauna from Ganzirri Lagoon (Sicily, Southern Italy)
We investigated the role of mullet as a biological tag to evaluate environmental status, mainly in a specific and circumscribed area, between March and June 2021, by conducting a survey of 150 mul... | |
PMC10000167 | Jennifer R. Weinert-Nelson,Amy S. Biddle,Harini Sampath,Carey A. Williams | Fecal Microbiota, Forage Nutrients, and Metabolic Responses of Horses Grazing Warm- and Cool-Season Grass Pastures | 22-02-2023 | equine microbiome,glycemic response,non-structural carbohydrates,rotational grazing | Simple Summary Incorporating warm-season grasses into traditional cool-season grass equine rotational grazing systems can increase pasture availability during hot, dry months and bridge the “summer slump” forage gap. The objective of this study was to evaluate the impacts of this pasture management practice on the equi... | Fecal Microbiota, Forage Nutrients, and Metabolic Responses of Horses Grazing Warm- and Cool-Season Grass Pastures
Incorporating warm-season grasses into traditional cool-season grass equine rotational grazing systems can increase pasture availability during hot, dry months and bridge the “summer slump” forage gap. Th... | |
PMC10000172 | Md. Ariful Islam,Md. Bayazid Hossen,Md. Abu Horaira,Md. Alim Hossen,Md. Kaderi Kibria,Md. Selim Reza,Khanis Farhana Tuly,Md. Omar Faruqe,Firoz Kabir,Rashidul Alam Mahumud,Md. Nurul Haque Mollah | Exploring Core Genes by Comparative Transcriptomics Analysis for Early Diagnosis, Prognosis, and Therapies of Colorectal Cancer | 21-02-2023 | colorectal cancer,gene expression profiles,core genes,early diagnosis,prognosis,therapies,integrated statistics and bioinformatics approaches | Simple Summary Colorectal cancer (CRC) is a complex disease that has a high mortality rate. This study explored CRC-related core genes (CGs) from multiple microarray gene-expression profiles in the NCBI-GEO database by combining some statistics and bioinformatics techniques. It also disclosed their molecular functions,... | Exploring Core Genes by Comparative Transcriptomics Analysis for Early Diagnosis, Prognosis, and Therapies of Colorectal Cancer
Colorectal cancer (CRC) is a complex disease that has a high mortality rate. This study explored CRC-related core genes (CGs) from multiple microarray gene-expression profiles in the NCBI-GEO... | |
PMC10000176 | Angeli Ambayya,Rozaimi Razali,Sarina Sulong,Ezzanie Suffya Zulkefli,Yee Yee Yap,Jameela Sathar,Rosline Hassan | Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing | 22-02-2023 | acute myeloid leukaemia,next generation sequencing,gene expression,somatic variants,functional enrichment | Simple Summary The characterisation of normal-karyotype acute myeloid leukaemia (AML-NK) requires further refinement based on genetic variations. In this study, we ascertained genomic biomarkers via DNA and RNA sequencing in eight AML-NK patients during diagnosis and after achieving complete remission. We discovered pu... | Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing
The characterisation of normal-karyotype acute myeloid leukaemia (AML-NK) requires further refinement based on genetic variations. In this study, we ascertain... | |
PMC10000182 | Hesham Ismail,Doaa Ibrahim,Shorouk El Sayed,Ali Wahdan,Reham M. El-Tarabili,Waleed Rizk El-Ghareeb,Bassam Abdullah Alhawas,Badr Abdul-Hakim Y. Alahmad,Sherief M. Abdel-Raheem,Marwa I. Abd El-Hamid | Prospective Application of Nanoencapsulated Bacillus amyloliquefaciens on Broiler Chickens’ Performance and Gut Health with Efficacy against Campylobacter jejuni Colonization | 21-02-2023 | probiotic-loaded nanoparticle,performance,C. jejuni,colonization,barrier function,poultry | Simple Summary The emergence of antibiotics resistance is a warning sign to limit antibiotics usage as growth promoters in the poultry industry. Probiotics served as superior candidates for replacing antibiotics in the poultry sector. However, the beneficial functions of probiotics did not reach their targeted outcomes... | Prospective Application of Nanoencapsulated Bacillus amyloliquefaciens on Broiler Chickens’ Performance and Gut Health with Efficacy against Campylobacter jejuni Colonization
The emergence of antibiotics resistance is a warning sign to limit antibiotics usage as growth promoters in the poultry industry. Probiotics ser... | |
PMC10000190 | Manuel Blonç,Jennifer Lima,Joan Carles Balasch,Lluis Tort,Carlos Gravato,Mariana Teles | Elucidating the Effects of the Lipids Regulators Fibrates and Statins on the Health Status of Finfish Species: A Review | 22-02-2023 | lipid-lowering agents,fibrates,statins,fish,gemfibrozil,atorvastatin | Simple Summary Pharmaceuticals used to treat abnormal cholesterol levels in the blood are known as lipid regulators (fibrates and statins), and their use is in constant growth. Treatment plants are usually unable to efficiently remove these compounds from wastewater, where their degradation rate is considerably slow, m... | Elucidating the Effects of the Lipids Regulators Fibrates and Statins on the Health Status of Finfish Species: A Review
Pharmaceuticals used to treat abnormal cholesterol levels in the blood are known as lipid regulators (fibrates and statins), and their use is in constant growth. Treatment plants are usually unable t... | |
PMC10000196 | Kazutoshi Fujita,Makoto Matsushita,Marco A. De Velasco,Koji Hatano,Takafumi Minami,Norio Nonomura,Hirotsugu Uemura | The Gut-Prostate Axis: A New Perspective of Prostate Cancer Biology through the Gut Microbiome | 21-02-2023 | gut,microbiome,prostate cancer,castration resistant prostate cancer,microbiota | Simple Summary The gut microbiome plays important roles in the development of several diseases. The gut microbiome is a dynamic system that is affected by several factors, such as dietary habits, and since prostate cancer and diet are closely linked, it is reasonable to hypothesize that a gut microbiome—affected by die... | The Gut-Prostate Axis: A New Perspective of Prostate Cancer Biology through the Gut Microbiome
The gut microbiome plays important roles in the development of several diseases. The gut microbiome is a dynamic system that is affected by several factors, such as dietary habits, and since prostate cancer and diet are clos... | |
PMC10000198 | Jun Chen,Xuehai Cao,Zhouyin Huang,Xingping Chen,Tiande Zou,Jinming You | Research Progress on Lycopene in Swine and Poultry Nutrition: An Update | 28-02-2023 | antioxidant,functional feed additive,lycopene,poultry,swine | Simple Summary Lycopene is a natural, red-colored pigment that is found in plants and has particularly robust antioxidant activity among the carotenoids. Plenty of research has highlighted its antioxidant, anti-inflammatory, anticancer, and antidiabetic properties. Emerging evidence has promoted the development of lyco... | Research Progress on Lycopene in Swine and Poultry Nutrition: An Update
Lycopene is a natural, red-colored pigment that is found in plants and has particularly robust antioxidant activity among the carotenoids. Plenty of research has highlighted its antioxidant, anti-inflammatory, anticancer, and antidiabetic properti... | |
PMC10000201 | Yiyue Ren,Zhen Song,Jens Rieser,Jörg Ackermann,Ina Koch,Xingyu Lv,Tong Ji,Xiujun Cai | USP15 Represses Hepatocellular Carcinoma Progression by Regulation of Pathways of Cell Proliferation and Cell Migration: A System Biology Analysis | 21-02-2023 | USP15,HCC,pathway analysis,system biology,cell behavior | Simple Summary Expression levels of the protein USP15 correlated with slow proliferation and slow migration of HCC cells. In HCC patients, high expression of USP15 in tumor tissue was associated with significantly decreased risk for mortality and cancer relapse. Overexpression of USP15 led to reduced tumor growth in a ... | USP15 Represses Hepatocellular Carcinoma Progression by Regulation of Pathways of Cell Proliferation and Cell Migration: A System Biology Analysis
Expression levels of the protein USP15 correlated with slow proliferation and slow migration of HCC cells. In HCC patients, high expression of USP15 in tumor tissue was ass... | |
PMC10000210 | Yunfa Xie,Zhiying Chen,Yanling Wang,Xiayun Peng,Ni Feng,Xiaoye Wang,Yinsheng Tang,Xun Li,Chunrong Xu,Chuanhuo Hu | Supplementation of Schisandrin B in Semen Extender Improves Quality and Oxidation Resistance of Boar Spermatozoa Stored at 4 °C | 25-02-2023 | schisandrin B,sperm quality,boar,oxidative stress | Simple Summary Sch B is the active component extracted from Sch B Fructus. It shows reproductive protection and spermatogenesis effects in animals. As far as we know, no research has been conducted with Sch B on boar semen preservation at 4 °C. Therefore, the current research aimed to explore the effects of Sch B on qu... | Supplementation of Schisandrin B in Semen Extender Improves Quality and Oxidation Resistance of Boar Spermatozoa Stored at 4 °C
Sch B is the active component extracted from Sch B Fructus. It shows reproductive protection and spermatogenesis effects in animals. As far as we know, no research has been conducted with Sch... | |
PMC10000225 | Cristián A. Valenzuela,Marco Azúa,Claudio A. Álvarez,Paulina Schmitt,Nicolás Ojeda,Luis Mercado | Evidence of the Autophagic Process during the Fish Immune Response of Skeletal Muscle Cells against Piscirickettsia salmonis | 28-02-2023 | autophagy,skeletal muscle,fish,immune response,Piscirickettsia salmonis | Simple Summary In mammals, autophagy plays a fundamental role in the defense against intracellular pathogens; however, in fish, this noncanonical function has not been described. In this context, it was proposed to study whether autophagy was modulated/activated in muscle cells challenged with a bacterial pathogen. Mus... | Evidence of the Autophagic Process during the Fish Immune Response of Skeletal Muscle Cells against Piscirickettsia salmonis
In mammals, autophagy plays a fundamental role in the defense against intracellular pathogens; however, in fish, this noncanonical function has not been described. In this context, it was propos... | |
PMC10000232 | Vincenzo Quagliariello,Irma Bisceglia,Massimiliano Berretta,Martina Iovine,Maria Laura Canale,Carlo Maurea,Vienna Giordano,Andrea Paccone,Alessandro Inno,Nicola Maurea | PCSK9 Inhibitors in Cancer Patients Treated with Immune-Checkpoint Inhibitors to Reduce Cardiovascular Events: New Frontiers in Cardioncology | 22-02-2023 | cardio-oncology,cardioprotection,cancer,immune-checkpoint inhibitors,atherosclerosis,cholesterol,inflammation | Simple Summary Atherosclerosis is a critical cardiovascular disease associated with the use of immune checkpoint inhibitors (ICIs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key orchestrator of atherosclerotic process and it is also involved in cancer progression and immune-resistance. In this context,... | PCSK9 Inhibitors in Cancer Patients Treated with Immune-Checkpoint Inhibitors to Reduce Cardiovascular Events: New Frontiers in Cardioncology
Atherosclerosis is a critical cardiovascular disease associated with the use of immune checkpoint inhibitors (ICIs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a k... | |
PMC10000233 | Chiara Benvenuti,Paola Tiberio,Mariangela Gaudio,Flavia Jacobs,Giuseppe Saltalamacchia,Sebastiano Pindilli,Alberto Zambelli,Armando Santoro,Rita De Sanctis | Potential Role of Circulating miRNAs for Breast Cancer Management in the Neoadjuvant Setting: A Road to Pave | 23-02-2023 | microRNAs,circulating miRNAs,breast cancer,neoadjuvant chemotherapy,pathological complete response | Simple Summary In breast cancer management, neoadjuvant chemotherapy is well established as therapeutic choice for selected high-risk early or locally advanced breast cancer. However, besides there being few clinical genomic classifiers, there is no technology that can predict for certain whether breast cancer patients... | Potential Role of Circulating miRNAs for Breast Cancer Management in the Neoadjuvant Setting: A Road to Pave
In breast cancer management, neoadjuvant chemotherapy is well established as therapeutic choice for selected high-risk early or locally advanced breast cancer. However, besides there being few clinical genomic ... | |
PMC10000238 | Chengbo Zhang,Junmin Chen,Qian Wu,Bo Xu,Zunxi Huang | The Gut Microbiota of Young Asian Elephants with Different Milk-Containing Diets | 02-03-2023 | Asian elephant,intestinal microbiota,diet,elephant milk,goat milk | Simple Summary Insufficient maternal milk is one of the important reasons for the low survival rate of young Asian elephants. Finding the optimal break milk supplementation for young Asian elephants is a matter of urgency. In our study, we investigated the microbiomes of young Asian elephants on different milk-containi... | The Gut Microbiota of Young Asian Elephants with Different Milk-Containing Diets
Insufficient maternal milk is one of the important reasons for the low survival rate of young Asian elephants. Finding the optimal break milk supplementation for young Asian elephants is a matter of urgency. In our study, we investigated ... | |
PMC10000248 | Xiaodong Gao,Xibao Wang,Xiaoyang Wu,Yongquan Shang,Xuesong Mei,Shengyang Zhou,Qinguo Wei,Guolei Sun,Yuehuan Dong,Weijia Cui,Honghai Zhang | Comparative Analyses of the Fecal Microbiome of Five Wild Black-Billed Capercaillie (Tetrao parvirostris) Flocks | 03-03-2023 | black-billed capercaillie (Tetrao parvirostris),fecal microbiome,function prediction,high-throughput sequencing | Simple Summary Black-billed capercaillie (Tetrao parvirostris) were listed as least concern (LC) class by the International Union for Conservation of Nature (IUCN). However, black-billed capercaillie was an endangered species in China and classified as first-class state protection animal (category I). Only a few studie... | Comparative Analyses of the Fecal Microbiome of Five Wild Black-Billed Capercaillie (Tetrao parvirostris) Flocks
Black-billed capercaillie (Tetrao parvirostris) were listed as least concern (LC) class by the International Union for Conservation of Nature (IUCN). However, black-billed capercaillie was an endangered spe... | |
PMC10000249 | Zirong Chen,Yan Fang,Weihong Jiang | Important Cells and Factors from Tumor Microenvironment Participated in Perineural Invasion | 21-02-2023 | perineural invasion (PNI),tumor microenvironment (TME),single-cell spatial transcriptomics (sc-ST) | Simple Summary Perineural invasion (PNI) as the fourth way for solid tumor metastasis and invasion has attracted a lot of attention, and axon growth and possible nerve “invasion” to tumors has also become an important component of PNI. We aim to summarize the current theories on the molecular mediators and pathogenesis... | Important Cells and Factors from Tumor Microenvironment Participated in Perineural Invasion
Perineural invasion (PNI) as the fourth way for solid tumor metastasis and invasion has attracted a lot of attention, and axon growth and possible nerve “invasion” to tumors has also become an important component of PNI. We aim... | |
PMC10000250 | Mit Joshi,Bhoomika M. Patel | Unveiling the Role of the Proton Gateway, Uncoupling Proteins (UCPs), in Cancer Cachexia | 23-02-2023 | cancer cachexia,uncoupling protein,mitochondria,muscle atrophy,metabolism,wasting syndrome,adipose tissue wasting | Simple Summary Cancer cachexia is a wasting syndrome mainly driven by chronic inflammation and high energy expenditure. The hyperactivation of the catabolic pathway leads to higher energy utilization by the body. Uncoupling proteins are involved in uncoupling the electron transport chain and thereby halting the ATP pro... | Unveiling the Role of the Proton Gateway, Uncoupling Proteins (UCPs), in Cancer Cachexia
Cancer cachexia is a wasting syndrome mainly driven by chronic inflammation and high energy expenditure. The hyperactivation of the catabolic pathway leads to higher energy utilization by the body. Uncoupling proteins are involved... | |
PMC10000275 | Ping Xiao,Zhangyue Shi,Chenang Liu,Darren E. Hagen | Characteristics of circulating small noncoding RNAs in plasma and serum during human aging | 22-02-2023 | aging clock,circulating sncRNAs,human aging,machine learning | Abstract Objective Aging is a complicated process that triggers age‐related disease susceptibility through intercellular communication in the microenvironment. While the classic secretome of senescence‐associated secretory phenotype (SASP) including soluble factors, growth factors, and extracellular matrix remodeling e... | Characteristics of circulating small noncoding RNAs in plasma and serum during human aging
Aging is a complicated process that triggers age‐related disease susceptibility through intercellular communication in the microenvironment. While the classic secretome of senescence‐associated secretory phenotype (SASP) includi... | |
PMC10000287 | Sakshi Mathur,Chaitali Gawas,Iffat Zareen Ahmad,Minal Wani,Heena Tabassum | Neurodegenerative disorders: Assessing the impact of natural vs drug‐induced treatment options | 22-02-2023 | herbal,mechanistic approach,neurodegenerative disorders,synthetic,treatment | Abstract Neurodegenerative illnesses refer to the gradual, cumulative loss of neural activity. Neurological conditions are considered to be the second leading cause of mortality in the modern world and the two most prevalent ones are Parkinson's disease and Alzheimer's disease. The negative side effects of pharmaceutic... | Neurodegenerative disorders: Assessing the impact of natural vs drug‐induced treatment options
Neurodegenerative illnesses refer to the gradual, cumulative loss of neural activity. Neurological conditions are considered to be the second leading cause of mortality in the modern world and the two most prevalent ones are... | |
PMC10000298 | Tian Tian,You Cai,Xin Qin,Jiangang Wang,Yali Wang,Xin Yang | Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism | 24-02-2023 | homeostasis,GABA,forebrain,cognition,E-I balance significance statement | Introduction Forebrain neural networks are vital for cognitive functioning, and their excitatory-inhibitory (E-I) balance is governed by neural homeostasis. However, the homeostatic control strategies and transcriptomic mechanisms that maintain forebrain E-I balance and optimal cognition remain unclear. Methods We used... | Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism
Forebrain neural networks are vital for cognitive functioning, and their excitatory-inhibitory (E-I) balance is governed by neural homeostasis. However, the homeostatic control strategies and transcripto... | |
PMC10000302 | Jianwei Zhao,Weihua Wang,Ke Yan,Haifeng Zhao,Zhen Zhang,Yu Wang,Wenyu Zhu,Shiwen Chen | RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus | 07-03-2023 | Traumatic brain injury,RNA-seq,Nup62,Bioinformatics,Hippocampus | Background Hippocampus impairment is a common condition encountered in the clinical diagnosis and treatment of traumatic brain injury (TBI). Several studies have investigated this phenomenon. However, its molecular mechanism remains unclear. Methods In this study, Illumina RNA-seq technology was used to determine the g... | RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus
Hippocampus impairment is a common condition encountered in the clinical diagnosis and treatment of traumatic brain injury (TBI). Several studies have investigated this phenomenon. However, its molecular m... | |
PMC10000306 | Tian Xiang,Longjiang Wu,Murtala Bindawa Isah,Chen Chen,Xiaoying Zhang | Apocynum venetum, a medicinal, economical and ecological plant: a review update | 07-03-2023 | Apocynum venetum L,Medicinal plant,Fibrous plant,CiteSpace | Apocynum venetum L. is an important medicinal perennial rhizome plant with good ecological and economic value. Its leaves have many pharmacological effects such as anti-inflammatory, anti-depression, anti-anxiolytic, etc., while its fibers have the title of “king of wild fibers”. Furthermore, it was suitable for the re... | Apocynum venetum, a medicinal, economical and ecological plant: a review update
Apocynum venetum L. is an important medicinal perennial rhizome plant with good ecological and economic value. Its leaves have many pharmacological effects such as anti-inflammatory, anti-depression, anti-anxiolytic, etc., while its fibers... | |
PMC10000335 | Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022 | 07-03-2023 | Cardiology,Global Health,Heart Health,Cardiovascular Disease,Conference | These are the abstracts from the combined 77th Brazilian Congress of Cardiology, together with the World Congress of Cardiology, held in October 2022. From 1950 to today, the World Heart Federation’s World Congress of Cardiology (WCC) has been a key event on the cardiovascular calendar, offering a global perspective on... | Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022
These are the abstracts from the combined 77th Brazilian Congress of Cardiology, together with the World Congress of Cardiology, held in October 2022. From 1950 to today, the World Heart Federation’s World Congress of Cardiology (WCC... | ||
PMC10000371 | Kai Gai,Yu Ge,Dapeng Liu,He Zhang,Bailin Cong,Shihao Guo,Yizheng Liu,Kai Xing,Xiaolong Qi,Xiangguo Wang,Longfei Xiao,Cheng Long,Yong Guo,Xihui Sheng | Identification of Key Genes Affecting Flavor Formation in Beijing-You Chicken Meat by Transcriptome and Metabolome Analyses | 28-02-2023 | meat flavor,Beijing-You chicken,transcriptome,metabolome,regulatory network | The flavor of chicken meat is influenced by muscle metabolites and regulatory genes and varies with age. In this study, the metabolomic and transcriptomic data of breast muscle at four developmental stages (days 1, 56, 98, and 120) of Beijing-You chickens (BJYs) were integrated and 310 significantly changed metabolites... | Identification of Key Genes Affecting Flavor Formation in Beijing-You Chicken Meat by Transcriptome and Metabolome Analyses
The flavor of chicken meat is influenced by muscle metabolites and regulatory genes and varies with age. In this study, the metabolomic and transcriptomic data of breast muscle at four developmen... | |
PMC10000373 | Samrat Roy Choudhury,Billie Heflin,Erin Taylor,Brian Koss,Nathan L. Avaritt,Alan J. Tackett | CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells | 24-02-2023 | melanoma,S100b,CRISPR,dCas9-KRAB,apoptosis,cell death | Overexpression of S100B is routinely used for disease-staging and for determining prognostic outcomes in patients with malignant melanoma. Intracellular interactions between S100B and wild-type (WT)-p53 have been demonstrated to limit the availability of free WT-p53 in tumor cells, inhibiting the apoptotic signaling ca... | CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
Overexpression of S100B is routinely used for disease-staging and for determining prognostic outcomes in patients with malignant melanoma. Intracellular interactions between S100B and wild-type (WT)-p53 have been demonstr... | |
PMC10000377 | Jung-Won Lee,You-Soub Lee,Min-Kyu Kim,Xin-Zi Chi,Dohun Kim,Suk-Chul Bae | Role of RUNX3 in Restriction Point Regulation | 23-02-2023 | RUNX3,K-RAS,R-point,cell cycle | A cell cycle is a series of events that takes place in a cell as it grows and divides. At the G1 phase of cell cycle, cells monitor their cumulative exposure to specific signals and make the critical decision to pass through the restriction (R)-point. The R-point decision-making machinery is fundamental to normal diffe... | Role of RUNX3 in Restriction Point Regulation
A cell cycle is a series of events that takes place in a cell as it grows and divides. At the G1 phase of cell cycle, cells monitor their cumulative exposure to specific signals and make the critical decision to pass through the restriction (R)-point. The R-point decision-... | |
PMC10000383 | Amol Gupta,Razelle Kurzrock,Jacob J. Adashek | Evolution of the Targeted Therapy Landscape for Cholangiocarcinoma: Is Cholangiocarcinoma the ‘NSCLC’ of GI Oncology? | 03-03-2023 | cholangiocarcinoma,targeted therapy,molecular biomarkers | Simple Summary In the past 20 years, the development of targeted therapies that can be matched to a tumor’s molecular and immune abnormalities has resulted in the improvement of outcomes for patients suffering from advanced aggressive malignancies. Remarkably, non-small cell lung cancer (NSCLC) has become the poster ch... | Evolution of the Targeted Therapy Landscape for Cholangiocarcinoma: Is Cholangiocarcinoma the ‘NSCLC’ of GI Oncology?
In the past 20 years, the development of targeted therapies that can be matched to a tumor’s molecular and immune abnormalities has resulted in the improvement of outcomes for patients suffering from a... | |
PMC10000388 | Fei-Yuan Yu,Qian Xu,Xiao-Yun Zhao,Hai-Ying Mo,Qiu-Hua Zhong,Li Luo,Andy T. Y. Lau,Yan-Ming Xu | The Atypical MAP Kinase MAPK15 Is Required for Lung Adenocarcinoma Metastasis via Its Interaction with NF-κB p50 Subunit and Transcriptional Regulation of Prostaglandin E2 Receptor EP3 Subtype | 22-02-2023 | MAPK15,EP3,p50,LUAD,metastasis | Simple Summary Due to the lack of effective early diagnostic markers for lung cancer and the rich blood circulation in the lungs, it is very easy to cause lymph node metastasis and distant metastasis of lung cancer, making lung cancer as one of the top ten cancer types with the highest mortality rate in the world. This... | The Atypical MAP Kinase MAPK15 Is Required for Lung Adenocarcinoma Metastasis via Its Interaction with NF-κB p50 Subunit and Transcriptional Regulation of Prostaglandin E2 Receptor EP3 Subtype
Due to the lack of effective early diagnostic markers for lung cancer and the rich blood circulation in the lungs, it is very ... | |
PMC10000409 | Eszter Emri,Oisin Cappa,Caoimhe Kelly,Elod Kortvely,John Paul SanGiovanni,Brian S. McKay,Arthur A. Bergen,David A. Simpson,Imre Lengyel | Zinc Supplementation Induced Transcriptional Changes in Primary Human Retinal Pigment Epithelium: A Single-Cell RNA Sequencing Study to Understand Age-Related Macular Degeneration | 28-02-2023 | zinc,retinal pigment epithelium,single-cell RNA sequencing,age-related macular degeneration,maturation | Zinc supplementation has been shown to be beneficial to slow the progression of age-related macular degeneration (AMD). However, the molecular mechanism underpinning this benefit is not well understood. This study used single-cell RNA sequencing to identify transcriptomic changes induced by zinc supplementation. Human ... | Zinc Supplementation Induced Transcriptional Changes in Primary Human Retinal Pigment Epithelium: A Single-Cell RNA Sequencing Study to Understand Age-Related Macular Degeneration
Zinc supplementation has been shown to be beneficial to slow the progression of age-related macular degeneration (AMD). However, the molecu... | |
PMC10000422 | Danielle K. DePalo,Jonathan S. Zager | Advances in Intralesional Therapy for Locoregionally Advanced and Metastatic Melanoma: Five Years of Progress | 23-02-2023 | advanced melanoma,in transit metastases,intralesional therapy,intratumoral therapy,local therapy,locoregional therapy,melanoma,metastatic melanoma,regional therapy,regional chemotherapy | Simple Summary The prognosis for patients with locoregionally advanced and metastatic melanoma remains poor despite advances in systemic therapy. By delivering therapeutics directly to the site(s) of disease, intralesional therapies have the advantage of delivering the oncolytic agent directly into the metastatic melan... | Advances in Intralesional Therapy for Locoregionally Advanced and Metastatic Melanoma: Five Years of Progress
The prognosis for patients with locoregionally advanced and metastatic melanoma remains poor despite advances in systemic therapy. By delivering therapeutics directly to the site(s) of disease, intralesional t... | |
PMC10000424 | Atharva Kale,Natasha M. Rogers | No Time to Die—How Islets Meet Their Demise in Transplantation | 03-03-2023 | islet transplantation,beta cells,rejection,IBMIR,ER stress | Islet transplantation represents an effective treatment for patients with type 1 diabetes mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing impaired counterregulatory pathways that no longer provide protection against low blood glucose levels. The additional beneficial effect of normalizing... | No Time to Die—How Islets Meet Their Demise in Transplantation
Islet transplantation represents an effective treatment for patients with type 1 diabetes mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing impaired counterregulatory pathways that no longer provide protection against low blood... | |
PMC10000425 | Hye-Jung Moon,Youn-Soo Cha,Kyung-Ah Kim | Blackcurrant Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice | 02-03-2023 | blackcurrant,whole foods,ulcerative colitis,anti-inflammation,tight junction proteins,gut microbiota | Previous studies have reported that anthocyanin (ACN)-rich materials have beneficial effects on ulcerative colitis (UC). Blackcurrant (BC) has been known as one of the foods rich in ACN, while studies demonstrating its effect on UC are rare. This study attempted to investigate the protective effects of whole BC in mice... | Blackcurrant Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
Previous studies have reported that anthocyanin (ACN)-rich materials have beneficial effects on ulcerative colitis (UC). Blackcurrant (BC) has been known as one of the foods rich in ACN, while studies demonstrating its effect on UC are rare. ... | |
PMC10000430 | Marta Santiago,Alessandro Liquori,Esperanza Such,Ángel Zúñiga,José Cervera | The Clinical Spectrum, Diagnosis, and Management of GATA2 Deficiency | 03-03-2023 | GATA2 deficiency,GATA2 haploinsufficiency,germline mutation,predisposition to myeloid neoplasms | Simple Summary A predisposition to myeloid neoplasms has recently been recognized as a defined clinical entity by the World Health Organization. One of the most well-known syndromes within this group is GATA2 deficiency, which is a highly heterogeneous disorder that can include pulmonary and vascular involvement, immun... | The Clinical Spectrum, Diagnosis, and Management of GATA2 Deficiency
A predisposition to myeloid neoplasms has recently been recognized as a defined clinical entity by the World Health Organization. One of the most well-known syndromes within this group is GATA2 deficiency, which is a highly heterogeneous disorder tha... | |
PMC10000431 | Carlo Antonio Beretta,Sheng Liu,Alina Stegemann,Zheng Gan,Lirong Wang,Linette Liqi Tan,Rohini Kuner | Quanty-cFOS, a Novel ImageJ/Fiji Algorithm for Automated Counting of Immunoreactive Cells in Tissue Sections | 23-02-2023 | quantitative analysis,immunohistochemistry,in situ hybridization,Fos protein,c-fos mRNA,2D automated cell counts,open-source ImageJ/Fiji tool | Analysis of neural encoding and plasticity processes frequently relies on studying spatial patterns of activity-induced immediate early genes’ expression, such as c-fos. Quantitatively analyzing the numbers of cells expressing the Fos protein or c-fos mRNA is a major challenge owing to large human bias, subjectivity an... | Quanty-cFOS, a Novel ImageJ/Fiji Algorithm for Automated Counting of Immunoreactive Cells in Tissue Sections
Analysis of neural encoding and plasticity processes frequently relies on studying spatial patterns of activity-induced immediate early genes’ expression, such as c-fos. Quantitatively analyzing the numbers of ... | |
PMC10000432 | Enrique Pérez-Riesgo,Elena Hernando-Pérez,Verónica Feijóo,Sendoa Tajada,Lucía Núñez,Carlos Villalobos | Transcriptional Basis of Ca2+ Remodeling Reversal Induced by Polyamine Synthesis Inhibition in Colorectal Cancer Cells | 04-03-2023 | colorectal cancer,polyamines,intracellular calcium,transcriptomic analysis,DFMO,store-operated calcium entry,mitochondria,TRP channels | Simple Summary The common activation of the c-Myc oncogene in colorectal cancer (CRC) induces the overexpression of ornithine decarboxylase (ODC), the limiting step in polyamine synthesis, which is a process blocked by α-Difluoromethylornithine (DFMO), an ODC suicide inhibitor and potential CRC treatment. We showed pre... | Transcriptional Basis of Ca2+ Remodeling Reversal Induced by Polyamine Synthesis Inhibition in Colorectal Cancer Cells
The common activation of the c-Myc oncogene in colorectal cancer (CRC) induces the overexpression of ornithine decarboxylase (ODC), the limiting step in polyamine synthesis, which is a process blocked... | |
PMC10000433 | Marjaana J. Häyrinen,Jenni Kiiskilä,Annamari Ranki,Liisa Väkevä,Henry J. Barton,Milla E. L. Kuusisto,Katja Porvari,Hanne Kuitunen,Kirsi-Maria Haapasaari,Hanna-Riikka Teppo,Outi Kuittinen | The Transcription Factor Twist1 Has a Significant Role in Mycosis Fungoides (MF) Cell Biology: An RNA Sequencing Study of 40 MF Cases | 28-02-2023 | cutaneous T-cell lymphoma,mycosis fungoides,Twist1,Zeb1,RNA sequencing,DNA methylation,laser capture microdissection | Simple Summary Mycosis fungoides (MF) is the most common variety of cutaneous T-cell lymphoma. Our previous studies showed that the epithelial–mesenchymal transition (EMT) transcription factors (TFs) Twist1 and Zeb1 have prognostic value in MF. The main objective of the present study was to gain better knowledge about ... | The Transcription Factor Twist1 Has a Significant Role in Mycosis Fungoides (MF) Cell Biology: An RNA Sequencing Study of 40 MF Cases
Mycosis fungoides (MF) is the most common variety of cutaneous T-cell lymphoma. Our previous studies showed that the epithelial–mesenchymal transition (EMT) transcription factors (TFs) ... | |
PMC10000435 | Javier Feito,Carlos Araújo,Sara Arbulu,Diogo Contente,Beatriz Gómez-Sala,Lara Díaz-Formoso,Estefanía Muñoz-Atienza,Juan Borrero,Luis M. Cintas,Pablo E. Hernández | Design of Lactococcus lactis Strains Producing Garvicin A and/or Garvicin Q, Either Alone or Together with Nisin A or Nisin Z and High Antimicrobial Activity against Lactococcus garvieae | 02-03-2023 | bacteriocins,garvicin,nisin,Lactococcus garvieae,lactic acid bacteria (LAB),heterologous production,Lactococcus lactis,probiotics,paraprobiotics,postbiotics | Lactococcus garvieae is a main ichthyopathogen in rainbow trout (Oncorhynchus mykiss, Walbaum) farming, although bacteriocinogenic L. garvieae with antimicrobial activity against virulent strains of this species have also been identified. Some of the bacteriocins characterized, such as garvicin A (GarA) and garvicin Q ... | Design of Lactococcus lactis Strains Producing Garvicin A and/or Garvicin Q, Either Alone or Together with Nisin A or Nisin Z and High Antimicrobial Activity against Lactococcus garvieae
Lactococcus garvieae is a main ichthyopathogen in rainbow trout (Oncorhynchus mykiss, Walbaum) farming, although bacteriocinogenic L... | |
PMC10000437 | Xiaojing Wei,Leilei Yu,Chuan Zhang,Yongqing Ni,Hao Zhang,Qixiao Zhai,Fengwei Tian | Genetic-Phenotype Analysis of Bifidobacterium bifidum and Its Glycoside Hydrolase Gene Distribution at Different Age Groups | 22-02-2023 | glycoside hydrolase (GH),Bifidobacterium bifidum,6’-sialyllactose,comparative genomics,genotype,phenotype | Human gut microbiota interfere with host development and aging. Bifidobacterium is a microbial genus found in the human digestive tract that has probiotic activities such as improving constipation and enhancing immunity. The species and numbers present change with age, but there has been limited research on probiotic g... | Genetic-Phenotype Analysis of Bifidobacterium bifidum and Its Glycoside Hydrolase Gene Distribution at Different Age Groups
Human gut microbiota interfere with host development and aging. Bifidobacterium is a microbial genus found in the human digestive tract that has probiotic activities such as improving constipatio... | |
PMC10000440 | Xiaoxiu Tan,Linfeng Xu,Xingxing Jian,Jian Ouyang,Bo Hu,Xinrong Yang,Tao Wang,Lu Xie | PGNneo: A Proteogenomics-Based Neoantigen Prediction Pipeline in Noncoding Regions | 01-03-2023 | neoantigen,noncoding regions,proteogenomics,prediction pipeline,tumor immunotherapy | The development of a neoantigen-based personalized vaccine has promise in the hunt for cancer immunotherapy. The challenge in neoantigen vaccine design is the need to rapidly and accurately identify, in patients, those neoantigens with vaccine potential. Evidence shows that neoantigens can be derived from noncoding seq... | PGNneo: A Proteogenomics-Based Neoantigen Prediction Pipeline in Noncoding Regions
The development of a neoantigen-based personalized vaccine has promise in the hunt for cancer immunotherapy. The challenge in neoantigen vaccine design is the need to rapidly and accurately identify, in patients, those neoantigens with ... | |
PMC10000455 | Luogen Peng,Yuchan Li,Sha Yao,Jochen Gaedcke,Victor M. Baart,Cornelis F. M. Sier,Albrecht Neesse,Volker Ellenrieder,Hanibal Bohnenberger,Frieder Fuchs,Julia Kitz,Philipp Ströbel,Stefan Küffer | Urokinase-Type Plasminogen Activator Receptor (uPAR) Cooperates with Mutated KRAS in Regulating Cellular Plasticity and Gemcitabine Response in Pancreatic Adenocarcinomas | 03-03-2023 | pancreatic cancer,uPAR,KRAS,FAK,MEK,ERK,dormancy,gemcitabine | Simple Summary Pancreatic ductal adenocarcinomas (PDACs) with gene amplification or overexpression of urokinase-type plasminogen activator receptor (uPAR) have a particularly dismal prognosis. We show here that uPAR reinforces the MEK/ERK signaling pathway in tumor cells with a KRAS mutation with the suppression of FAK... | Urokinase-Type Plasminogen Activator Receptor (uPAR) Cooperates with Mutated KRAS in Regulating Cellular Plasticity and Gemcitabine Response in Pancreatic Adenocarcinomas
Pancreatic ductal adenocarcinomas (PDACs) with gene amplification or overexpression of urokinase-type plasminogen activator receptor (uPAR) have a p... | |
PMC10000459 | Ozioma S. Chioma,Elizabeth Mallott,Binal Shah-Gandhi,ZaDarreyal Wiggins,Madison Langford,Andrew William Lancaster,Alexander Gelbard,Hongmei Wu,Joyce E. Johnson,Lisa Lancaster,Erin M. Wilfong,Leslie J. Crofford,Courtney G. Montgomery,Luc Van Kaer,Seth Bordenstein,Dawn C. Newcomb,Wonder Puryear Drake | Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease | 28-02-2023 | estrogen,gut microbiome,lung fibrosis,sarcoidosis,Th17 cells | Although profibrotic cytokines, such as IL-17A and TGF-β1, have been implicated in the pathogenesis of interstitial lung disease (ILD), the interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic cytokine expression, such as the phosphorylation of STAT3, have not been defined. ... | Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease
Although profibrotic cytokines, such as IL-17A and TGF-β1, have been implicated in the pathogenesis of interstitial lung disease (ILD), the interactions between gut dysbiosis, gonadotrophic hormones ... | |
PMC10000467 | Liang-Wei Lin,Shih-Wei Wang,Wei-Chien Huang,Thanh Kieu Huynh,Chao-Yang Lai,Chih-Yuan Ko,Yi-Chin Fong,Jie-Jen Lee,Shun-Fa Yang,Chih-Hsin Tang | Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration | 03-03-2023 | melatonin,endothelial progenitor cells,vascular endothelial growth factor (VEGF),platelet-derived growth factor-BB (PDGF-BB),angiogenesis,neovascular age-related macular degeneration | Neovascular age-related macular degeneration (AMD) is described as abnormal angiogenesis in the retina and the leaking of fluid and blood that generates a huge, dark, blind spot in the center of the visual field, causing severe vision loss in over 90% of patients. Bone marrow-derived endothelial progenitor cells (EPCs)... | Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration
Neovascular age-related macular degeneration (AMD) is described as abnormal angiogenesis in the retina and the leaking of fluid and blood that generates a huge, dark, blind spot in the center of the... | |
PMC10000468 | Sang R. Lee,Moeka Mukae,Kang Joo Jeong,Se Hee Park,Hi Jo Shin,Sang Woon Kim,Young Suk Won,Hyo-Jung Kwun,In-Jeoung Baek,Eui-Ju Hong | PGRMC1 Ablation Protects from Energy-Starved Heart Failure by Promoting Fatty Acid/Pyruvate Oxidation | 27-02-2023 | Pgrmc1,heart,starvation,ischemia,metabolism | Heart failure (HF) is an emerging epidemic with a high mortality rate. Apart from conventional treatment methods, such as surgery or use of vasodilation drugs, metabolic therapy has been suggested as a new therapeutic strategy. The heart relies on fatty acid oxidation and glucose (pyruvate) oxidation for ATP-mediated c... | PGRMC1 Ablation Protects from Energy-Starved Heart Failure by Promoting Fatty Acid/Pyruvate Oxidation
Heart failure (HF) is an emerging epidemic with a high mortality rate. Apart from conventional treatment methods, such as surgery or use of vasodilation drugs, metabolic therapy has been suggested as a new therapeutic... | |
PMC10000476 | 36899881 | Kalee N. Holloway,Marisa R. Pinson,James C. Douglas,Tonya M. Rafferty,Cynthia J. M. Kane,Rajesh C. Miranda,Paul D. Drew | Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression | 25-02-2023 | AUD,astrocyte,microglia,oligodendrocyte,neuroinflammation,transcriptomics | Alcohol use disorder (AUD) is one of the most common preventable mental health disorders and can result in pathology within the CNS, including the cerebellum. Cerebellar alcohol exposure during adulthood has been associated with disruptions in proper cerebellar function. However, the mechanisms regulating ethanol-induc... | Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression
Alcohol use disorder (AUD) is one of the most common preventable mental health disorders and can result in pathology within the CNS, including ... |
PMC10000477 | Natasa Nikolic,Branka Basica,Aljosa Mandic,Nela Surla,Vera Gusman,Deana Medic,Tamas Petrovic,Mirjana Strbac,Vladimir Petrovic | E6/E7 mRNA Expression of the Most Prevalent High-Risk HPV Genotypes in Cervical Samples from Serbian Women | 28-02-2023 | E6,E7,HPV,cervical intraepithelial lesion,biomarker,Serbia | Cervical cancer caused by persistent infection with HR HPV genotypes is the second leading cause of death in women aged 15 to 44 in Serbia. The expression of the E6 and E7 HPV oncogenes is considered as a promising biomarker in diagnosing high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate ... | E6/E7 mRNA Expression of the Most Prevalent High-Risk HPV Genotypes in Cervical Samples from Serbian Women
Cervical cancer caused by persistent infection with HR HPV genotypes is the second leading cause of death in women aged 15 to 44 in Serbia. The expression of the E6 and E7 HPV oncogenes is considered as a promisi... | |
PMC10000481 | Kristin E. Zorn,Ashley M. Cunningham,Alison E. Meyer,Karen Sue Carlson,Sridhar Rao | Pediatric Myeloid Sarcoma, More than Just a Chloroma: A Review of Clinical Presentations, Significance, and Biology | 24-02-2023 | myeloid sarcoma,chloroma,acute myeloid leukemia,pediatric | Simple Summary Childhood acute myeloid leukemia (AML) remains a cancer with poor overall outcomes. Myeloid sarcomas (MS) are extramedullary masses of leukemia cells that can develop in patients with AML. In children, MS occurs more frequently than described in adults. Their clinical significance in both pediatric and a... | Pediatric Myeloid Sarcoma, More than Just a Chloroma: A Review of Clinical Presentations, Significance, and Biology
Childhood acute myeloid leukemia (AML) remains a cancer with poor overall outcomes. Myeloid sarcomas (MS) are extramedullary masses of leukemia cells that can develop in patients with AML. In children, M... | |
PMC10000483 | MHD Ouis Al Khatib,Giulia Pinton,Laura Moro,Chiara Porta | Benefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma | 28-02-2023 | EZH2,malignant pleural mesothelioma,epigenetic,tumor microenvironment,macrophages,immune infiltrate,immunotherapy,targeted therapy | Simple Summary Malignant pleural mesothelioma (MPM) is an aggressive cancer linked to asbestos exposure with an extremely poor outcome. Despite the recent approval of immune checkpoint blockade-based therapies, MPM still remains a fatal cancer that challenges physicians and scientists. Enhancer of zeste homolog 2 (EZH2... | Benefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive cancer linked to asbestos exposure with an extremely poor outcome. Despite the recent approval of immune checkpoint blockade-based therapies, MPM still remains a fatal cancer that challeng... | |
PMC10000491 | Lei Wu,Liming Gao,Xiang Jin,Zhikang Chen,Xutong Qiao,Xiting Cui,Jianhua Gao,Liwei Zhang | Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway | 04-03-2023 | Mao Jian Green Tea,ethanol extract,gastrointestinal motility,5-hydroxytryptamine,gut microbiota,flavonoids | In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes gastrointestinal motility. In this study, the effect of MJGT ethanol extract (MJGT_EE) in treating irritable bowel syndrome with constipation (IBS-C) in a rat model constructed via maternal separation combined with an ice ... | Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway
In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT) promotes gastrointestinal motility. In this stud... | |
PMC10000492 | Ching-Hu Wu,Chien-Wei Feng,Chiu-Lin Wang,Zhi-Hong Wen,Cheng-Yu Long,Feng-Hsiang Tang | Zinc Finger Protein 90 Knockdown Promotes Cisplatin Sensitivity via Nrf2/HO-1 Pathway in Ovarian Cancer Cell | 03-03-2023 | zinc finger protein 90,ovarian cancer,cisplatin sensitivity,apoptosis,nuclear factor E2-related factor 2 | Simple Summary Our data suggested that cisplatin treatment generates reactive oxygen species (ROS) that modulate apoptotic proteins expression (p-P38, p-ERK, p-Akt, Bcl-2, Bax, active caspase-3). The anti-oxidative signal (Nrf2, HO-1, SOD) was also activated, which could inhibit cell migration (MMP-2, MMP-9, E-cadherin... | Zinc Finger Protein 90 Knockdown Promotes Cisplatin Sensitivity via Nrf2/HO-1 Pathway in Ovarian Cancer Cell
Our data suggested that cisplatin treatment generates reactive oxygen species (ROS) that modulate apoptotic proteins expression (p-P38, p-ERK, p-Akt, Bcl-2, Bax, active caspase-3). The anti-oxidative signal (Nr... | |
PMC10000495 | Praewa Suthapot,Wararat Chiangjong,Parunya Chaiyawat,Pongsakorn Choochuen,Dumnoensun Pruksakorn,Surasak Sangkhathat,Suradej Hongeng,Usanarat Anurathapan,Somchai Chutipongtanate | Genomics-Driven Precision Medicine in Pediatric Solid Tumors | 23-02-2023 | precision medicine,pediatric solid tumor,actionable mutations | Simple Summary The detection of genomic aberrations in cancers has yielded a wealth of information to discover oncogenic drivers or pathogenic variants that are relevant for the development of precise treatment strategies. Recent studies have shown promising outcomes in adult cancer patients with well characterized can... | Genomics-Driven Precision Medicine in Pediatric Solid Tumors
The detection of genomic aberrations in cancers has yielded a wealth of information to discover oncogenic drivers or pathogenic variants that are relevant for the development of precise treatment strategies. Recent studies have shown promising outcomes in ad... | |
PMC10000504 | Chengcheng Liu,Yuying Huo,Yansong Zhang,Fumei Yin,Taoyu Chen,Zhenyi Wang,Juntao Gao,Peng Jin,Xiangyu Li,Minglei Shi,Michael Q. Zhang | Development and Experimental Validation of a Novel Prognostic Signature for Gastric Cancer | 05-03-2023 | gastric cancer,prognostic signature,tumor microenvironment,oncogenic mutation,clinical outcomes,machine learning | Simple Summary Gastric cancer (GC) accounts for a considerable amount of morbidity and mortality worldwide. This study developed and experimentally validated a prognostic risk gene signature (PRGS). This is a stable and robust signature for assessing the prognosis of gastric cancer. We performed multiple analyses throu... | Development and Experimental Validation of a Novel Prognostic Signature for Gastric Cancer
Gastric cancer (GC) accounts for a considerable amount of morbidity and mortality worldwide. This study developed and experimentally validated a prognostic risk gene signature (PRGS). This is a stable and robust signature for as... | |
PMC10000517 | Sanjive Qazi,Fatih M. Uckun | CD22 Exon 12 Deletion as an Independent Predictor of Poor Treatment Outcomes in B-ALL | 04-03-2023 | B-ALL,CD22,mRNA,relapse,aberrant splicing,SIGLEC-2 | Simple Summary We previously reported that cancer cells from the most common type of childhood cancer, namely, a form of acute leukemia known as B-ALL, are characterized by an abnormality known as CD22 exon 12 deletion. The purpose of the present study was to evaluate the clinical significance of the CD22 exon 12 delet... | CD22 Exon 12 Deletion as an Independent Predictor of Poor Treatment Outcomes in B-ALL
We previously reported that cancer cells from the most common type of childhood cancer, namely, a form of acute leukemia known as B-ALL, are characterized by an abnormality known as CD22 exon 12 deletion. The purpose of the present s... | |
PMC10000519 | Emily L. Chávez-Delgado,Daniel A. Jacobo-Velázquez | Essential Oils: Recent Advances on Their Dual Role as Food Preservatives and Nutraceuticals against the Metabolic Syndrome | 03-03-2023 | essential oils,metabolic syndrome,diabetes,obesity,neuroprotection,antioxidant,antimicrobial,nanoencapsulation | Essential oils (EO) are compounds synthesized by plants as secondary products and are a complex mixture of volatile molecules. Studies have demonstrated their pharmacological activity in the prevention and treatment of metabolic syndrome (MetS). Moreover, they have been used as antimicrobial and antioxidant food additi... | Essential Oils: Recent Advances on Their Dual Role as Food Preservatives and Nutraceuticals against the Metabolic Syndrome
Essential oils (EO) are compounds synthesized by plants as secondary products and are a complex mixture of volatile molecules. Studies have demonstrated their pharmacological activity in the preve... | |
PMC10000521 | Roberto Fernández-Acosta,Behrouz Hassannia,Jurgen Caroen,Bartosz Wiernicki,Daniel Alvarez-Alminaque,Bruno Verstraeten,Johan Van der Eycken,Peter Vandenabeele,Tom Vanden Berghe,Gilberto L. Pardo-Andreu | Molecular Mechanisms of Nemorosone-Induced Ferroptosis in Cancer Cells | 24-02-2023 | nemorosone,ferroptosis,mitochondrial uncoupling,fibrosarcoma,neuroblastoma | Ferroptosis is an iron-dependent cell death-driven by excessive peroxidation of polyunsaturated fatty acids (PUFAs) of membranes. A growing body of evidence suggests the induction of ferroptosis as a cutting-edge strategy in cancer treatment research. Despite the essential role of mitochondria in cellular metabolism, b... | Molecular Mechanisms of Nemorosone-Induced Ferroptosis in Cancer Cells
Ferroptosis is an iron-dependent cell death-driven by excessive peroxidation of polyunsaturated fatty acids (PUFAs) of membranes. A growing body of evidence suggests the induction of ferroptosis as a cutting-edge strategy in cancer treatment resear... | |
PMC10000525 | Rina Bandopadhyay,Ariana Gatt,Tammaryn Lashley | Advances in the Understanding of Frontotemporal Dementia | 01-03-2023 | Advances in the Understanding of Frontotemporal Dementia
Frontotemporal dementia (FTD) encompasses a group of clinically, genetically and pathologically heterogeneous neurodegenerative disorders that mainly affect people under the age of 64 years. However, around 25% of those affected have a later age of onset. FTD re... | |||
PMC10000527 | Jordi Duran | Role of Astrocytes in the Pathophysiology of Lafora Disease and Other Glycogen Storage Disorders | 24-02-2023 | glycogen,aggregation,Lafora disease,neuroinflammation,neurodegeneration,epilepsy | Lafora disease is a rare disorder caused by loss of function mutations in either the EPM2A or NHLRC1 gene. The initial symptoms of this condition are most commonly epileptic seizures, but the disease progresses rapidly with dementia, neuropsychiatric symptoms, and cognitive deterioration and has a fatal outcome within ... | Role of Astrocytes in the Pathophysiology of Lafora Disease and Other Glycogen Storage Disorders
Lafora disease is a rare disorder caused by loss of function mutations in either the EPM2A or NHLRC1 gene. The initial symptoms of this condition are most commonly epileptic seizures, but the disease progresses rapidly wit... | |
PMC10000528 | Abdullah Alfaifi,Mohammed Y. Refai,Mohammed Alsaadi,Salem Bahashwan,Hafiz Malhan,Waiel Al-Kahiry,Enas Dammag,Ageel Ageel,Amjed Mahzary,Raed Albiheyri,Hussein Almehdar,Ishtiaq Qadri | Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma | 23-02-2023 | metabolomics,B-cell non-Hodgkin’s lymphoma,biomarkers,metabolites,early diagnosis,therapeutic | A wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin’s lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essential because early remedial actions taken against destructive subtypes are commonly deliber... | Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma
A wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin’s lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essentia... | |
PMC10000530 | Juanjuan Wang,Ningning Zhu,Xiaomin Su,Yunhuan Gao,Rongcun Yang | Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis | 02-03-2023 | gut microbiota,SCFAs,tryptophan metabolites,bile acid metabolites,tolerogenic macrophages,regulatory T cells | The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the gastrointestinal tract. This commensal microbiota can contribute to the regulation of host immune response and homeostasis. Alterations of the gut microbiota have been found in many immune-related diseases. The metabolites generate... | Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis
The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the gastrointestinal tract. This commensal microbiota can contribute to the regulation of host immune response and homeostasis. Alterations of the gut mic... | |
PMC10000531 | Marcin Czop,Karolina Gasińska,Ewa Kosior-Jarecka,Dominika Wróbel-Dudzińska,Janusz Kocki,Tomasz Żarnowski | Twenty Novel MicroRNAs in the Aqueous Humor of Pseudoexfoliation Glaucoma Patients | 24-02-2023 | miRNA,aqueous humor,pseudoexfoliation glaucoma,PEXG,glaucoma,pseudoexfoliation syndrome,PEX | The microRNAs (miRNAs) are short non-coding RNAs (19–25 nt) that regulate the level of gene expression at the post-transcriptional stage. Altered miRNAs expression can lead to the development of various diseases, e.g., pseudoexfoliation glaucoma (PEXG). In this study, we assessed the levels of miRNA expression in the a... | Twenty Novel MicroRNAs in the Aqueous Humor of Pseudoexfoliation Glaucoma Patients
The microRNAs (miRNAs) are short non-coding RNAs (19–25 nt) that regulate the level of gene expression at the post-transcriptional stage. Altered miRNAs expression can lead to the development of various diseases, e.g., pseudoexfoliation... | |
PMC10000532 | Yao Song,Lei Wang,Kaidong Wang,Yuhua Lu,Pengcheng Zhou | COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation | 26-02-2023 | pancreatic cancer,cancer-associated fibroblasts,COL12A1,TCGA,prognosis | Simple Summary Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that play a crucial role in tumor progression in pancreatic cancer. Thus, uncovering the key genes involved in CAF progression and determining their prognostic value is critically important. Analysis of The Can... | COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation
Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that play a crucial role in tumor progression in pancreatic canc... | |
PMC10000543 | Zhen Chen,Han Bao,Jingfang Long,Peiqi Zhao,Xiaowei Hu,Hao Wang,Ying Zhang,Jianjing Yang,Qichuan Zhuge,Lei Xia | GBE1 Promotes Glioma Progression by Enhancing Aerobic Glycolysis through Inhibition of FBP1 | 03-03-2023 | glucan branching enzyme 1,Warburg effect,glucose metabolism,fructose-bisphosphatase 1,NF-κB | Simple Summary Due to the poor prognosis of glioma patients and the limitations of glioma treatment, our study aimed to find new targets for glioma on metabolic therapy. Our study reveals a role for glycogen branching enzyme 1 (GBE1) in regulating glioma initiation and progression. We found that the expression of GBE1 ... | GBE1 Promotes Glioma Progression by Enhancing Aerobic Glycolysis through Inhibition of FBP1
Due to the poor prognosis of glioma patients and the limitations of glioma treatment, our study aimed to find new targets for glioma on metabolic therapy. Our study reveals a role for glycogen branching enzyme 1 (GBE1) in regul... | |
PMC10000544 | Xiaoming Li,Sebastian Kempf,Stefan Günther,Jiong Hu,Ingrid Fleming | 11,12-EET Regulates PPAR-γ Expression to Modulate TGF-β-Mediated Macrophage Polarization | 23-02-2023 | soluble epoxide hydrolase,PPAR-γ,macrophage,resolution of inflammation,11,12-epoxyeicosatrienoic acid | Macrophages are highly plastic immune cells that can be reprogrammed to pro-inflammatory or pro-resolving phenotypes by different stimuli and cell microenvironments. This study set out to assess gene expression changes associated with the transforming growth factor (TGF)-β-induced polarization of classically activated ... | 11,12-EET Regulates PPAR-γ Expression to Modulate TGF-β-Mediated Macrophage Polarization
Macrophages are highly plastic immune cells that can be reprogrammed to pro-inflammatory or pro-resolving phenotypes by different stimuli and cell microenvironments. This study set out to assess gene expression changes associated ... | |
PMC10000563 | Justine N. van der Beek,Ronald R. de Krijger,Rutger A. J. Nievelstein,Axel Bex,Aart J. Klijn,Marry M. van den Heuvel-Eibrink,Annemieke S. Littooij | MRI Characteristics of Pediatric and Young-Adult Renal Cell Carcinoma: A Single-Center Retrospective Study and Literature Review | 22-02-2023 | renal cell carcinoma,magnetic resonance imaging,pediatrics,radiology,pathology | Simple Summary Whereas renal cell carcinoma (RCC) is the most common renal tumor in adults, pediatric RCC is a rare malignancy. The previous literature focusing on cross-sectional imaging of RCC concerns mainly computed tomography in adults, whereas in children, a different distribution of subtypes is seen, as well as ... | MRI Characteristics of Pediatric and Young-Adult Renal Cell Carcinoma: A Single-Center Retrospective Study and Literature Review
Whereas renal cell carcinoma (RCC) is the most common renal tumor in adults, pediatric RCC is a rare malignancy. The previous literature focusing on cross-sectional imaging of RCC concerns m... | |
PMC10000565 | Hwang-Ju Jeon,Kyeongnam Kim,Chaeeun Kim,Sung-Eun Lee | Antimelanogenic Effects of Curcumin and Its Dimethoxy Derivatives: Mechanistic Investigation Using B16F10 Melanoma Cells and Zebrafish (Danio rerio) Embryos | 22-02-2023 | curcumin derivative,melanogenesis,MC1R signaling pathway,zebrafish,melanin production,whitening agent | Regulation of melanin production via the MC1R signaling pathway is a protective mechanism of the skin of living organisms against exposure to ultraviolet rays. The discovery of human skin-whitening agents has been one of the most intense pursuits of the cosmetic industry. The MC1R signaling pathway is activated by its ... | Antimelanogenic Effects of Curcumin and Its Dimethoxy Derivatives: Mechanistic Investigation Using B16F10 Melanoma Cells and Zebrafish (Danio rerio) Embryos
Regulation of melanin production via the MC1R signaling pathway is a protective mechanism of the skin of living organisms against exposure to ultraviolet rays. Th... | |
PMC10000578 | Laura Boyero,José Francisco Noguera-Uclés,Alejandro Castillo-Peña,Ana Salinas,Amparo Sánchez-Gastaldo,Miriam Alonso,Johana Cristina Benedetti,Reyes Bernabé-Caro,Luis Paz-Ares,Sonia Molina-Pinelo | Aberrant Methylation of the Imprinted C19MC and MIR371-3 Clusters in Patients with Non-Small Cell Lung Cancer | 25-02-2023 | DNA methylation,C19MC and MIR371-3 clusters,miRNA–target mRNA expression,prognosis,non-small cell lung cancer (NSCLC) | Simple Summary Aberrations in DNA methylation profiles may alter the expression of key miRNAs in non-small cell lung cancer. In this study, we focus on the analysis of the imprinted C19MC and MIR371-3 miRNA clusters due to their oncogenic role. We identified the DNA methylation status and discovered its deregulated tar... | Aberrant Methylation of the Imprinted C19MC and MIR371-3 Clusters in Patients with Non-Small Cell Lung Cancer
Aberrations in DNA methylation profiles may alter the expression of key miRNAs in non-small cell lung cancer. In this study, we focus on the analysis of the imprinted C19MC and MIR371-3 miRNA clusters due to t... | |
PMC10000581 | Lara Tinacci,Deyan Stratev,Mariyana Strateva,Georgi Zhelyazkov,Ralica Kyuchukova,Andrea Armani | An Authentication Survey on Retail Seafood Products Sold on the Bulgarian Market Underlines the Need for Upgrading the Traceability System | 02-03-2023 | seafood labeling,authenticity,mislabeling,DNA barcoding,PCR–RFLP analysis seafood,marking | Economically motivated or accidental species substitutions lead to economic and potential health damage to consumers with a loss of confidence in the fishery supply chain. In the present study, a three–year survey on 199 retail seafood products sold on the Bulgarian market was addressed to assess: (1) product authentic... | An Authentication Survey on Retail Seafood Products Sold on the Bulgarian Market Underlines the Need for Upgrading the Traceability System
Economically motivated or accidental species substitutions lead to economic and potential health damage to consumers with a loss of confidence in the fishery supply chain. In the p... |