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A_N_A_Lobar_Degeneration

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subject stringlengths 64 104	txt_report stringlengths 1.37k 4.93k	gold_diagnosis stringclasses 5 values	cognitive_txt stringlengths 99 3.62k
ADNI_099_S_6038_MR_Accelerated_Sag_IR-FSPGR___br_raw_20170920110402990_188_S610151_I905866	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the putamen - accumbens appears within normal limits without apparent atrophy - no observable atrophic changes in the amygdala - no evident atrophy or tissue thinning seen in the pallidum - caudate maintains a normal appearance with no observable atrophic features - mild atrophy of the left thalamus; the right thalamus is normal - hippocampus maintains a normal appearance with no observable atrophic features For the cerebral cortex: - limbic cortex maintains a normal appearance with no observable atrophic features - no observable atrophic changes in the temporal lobe - no observable atrophic changes in the frontal lobe - mild atrophy of the left parietal lobe and mild-to-moderate atrophy of the right parietal lobe; focal volume loss observed in the following subregions: precuneus (mild atrophy both left and right) and angular gyrus (mild atrophy on the right) - occipital lobe appears within normal limits without apparent atrophy - mild atrophy of the left insular cortex; the right insular cortex is normal; focal volume loss observed in the following subregions: central operculum (mild atrophy on the left and normal-to-mild atrophy on the right) and posterior insula (mild atrophy on the left) For the ventricles: - lateral ventricle appears to be of normal dimensions, with no observable increase in size - 4th ventricle maintains a typical volume without observable enlargement - inf. lateral ventricle maintains its expected proportions without signs of enlargement - moderate enlargement of the external csf - no findings suggestive of enlargement are seen in the 3rd ventricle For additional Regions of Interest: - the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a male of 77.7 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 22 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 26. On the Trail Making Test Part B, his total number of seconds to complete is 181. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203522833_02332_MR_Sagittal_MP-Rage_br_raw_20230209101231374_I10183395	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild atrophy of the left amygdala; normal-to-mild atrophy of the right amygdala - mild atrophy of the right caudate; normal-to-mild atrophy of the left caudate - mild atrophy of the left accumbens; normal-to-mild atrophy of the right accumbens - mild bilateral atrophy of the thalamus - mild bilateral atrophy of the putamen - no clear atrophic alterations are visible in the hippocampus - mild bilateral atrophy of the pallidum For the cerebral cortex: - mild atrophy of the right limbic cortex; the left limbic cortex is normal; focal volume loss observed in the following subregions: posterior cingulate gyrus (mild atrophy both left and right), parahippocampal gyrus (mild atrophy both left and right) and entorhinal area (normal on the left and mild atrophy on the right) - the parietal lobe shows no notable changes suggestive of atrophy - no appreciable degenerative or atrophic changes observed in the occipital lobe - the temporal lobe shows no notable changes suggestive of atrophy - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: central operculum (mild atrophy on the left and normal-to-mild atrophy on the right), posterior insula (normal on the left and mild atrophy on the right) and anterior insula (mild atrophy on the left and normal on the right) - frontal lobe appears within normal limits without apparent atrophy For the ventricles: - mild enlargement of the 4th ventricle - mild-to-moderate enlargement of the left inf. lateral ventricle and mild enlargement of the right inf. lateral ventricle - mild-to-moderate enlargement of the external csf - mild-to-moderate bilateral enlargement of the lateral ventricle - mild enlargement of the 3rd ventricle For additional Regions of Interest: - mild atrophy of the right speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex); the left speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) is normal	BV	We have the following subject's personal information: - The subject is a male of 75.0 years old. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 21 animals in 60 seconds. He named 12 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 18. - On the Number Span forward test, his longest span forward was 7. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 37, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in irritability or lability, appetite and eating, a moderate (significant, but not dramatic) change in agitation or aggression, depression or dysphoria, anxiety, apathy or indifference, disinhibition. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 8.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 2.0 (moderate impairment). Description: Severely impaired in handling problems, similarities, and differences; social judgment usually impaired. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 2.0 (moderate impairment). Description: Requires much help with personal care; frequent incontinence. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
FTLD_203553373_03375_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10450626	On a T1-weighted brain MRI we observed: For the ventricles: - 4th ventricle maintains its expected proportions without signs of enlargement - no clear enlargement or abnormal growth seen in the 3rd ventricle - no evident size increase noted in the inf. lateral ventricle - external csf appears to be of normal dimensions, with no observable increase in size - no findings suggestive of enlargement are seen in the lateral ventricle For the cerebral cortex: - the occipital lobe shows no notable changes suggestive of atrophy - limbic cortex maintains a normal appearance with no observable atrophic features - the parietal lobe shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the temporal lobe - the frontal lobe shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the insular cortex For the subcortical structures: - hippocampus maintains a normal appearance with no observable atrophic features - thalamus appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the amygdala - no observable atrophic changes in the putamen - no appreciable degenerative or atrophic changes observed in the accumbens - caudate maintains a normal appearance with no observable atrophic features - pallidum appears within normal limits without apparent atrophy For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a female of 57.0 years old. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 29. - On the semantic categorical fluency test, the subject named 27 animals in 60 seconds. She named 17 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 7. - On the Number Span forward test, her longest span forward was 7. On the Number Span backward test, her longest span backward was 4. - On the Trail Making Test Part A, her total number of seconds to complete is 22, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 42, her number of commission errors is 0, her number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in anxiety. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_100_S_6713_MR_Sagittal_3D_Accelerated_MPRAGE_br_raw_20190418160341621_1_S817034_I1156438	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild atrophy of the right frontal lobe; the left frontal lobe is normal; focal volume loss observed in the following subregions: anterior orbital gyrus (mild atrophy on the right), triangular inf. frontal gyrus (mild atrophy both left and right), medial frontal cortex (mild atrophy on the right), medial orbital gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and supplementary motor cortex (mild-to-moderate atrophy on the right) - no evident atrophy or tissue thinning seen in the temporal lobe - insular cortex demonstrates a healthy morphology without signs of atrophy - no evident atrophy or tissue thinning seen in the occipital lobe - no clear atrophic alterations are visible in the parietal lobe - limbic cortex maintains a normal appearance with no observable atrophic features For the subcortical structures: - mild-to-moderate atrophy of the left amygdala and mild atrophy of the right amygdala - no appreciable degenerative or atrophic changes observed in the accumbens - caudate appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the pallidum - mild-to-moderate atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild atrophy of the right thalamus; normal-to-mild atrophy of the left thalamus - putamen maintains a normal appearance with no observable atrophic features For the ventricles: - inf. lateral ventricle maintains a typical volume without observable enlargement - no evident size increase noted in the 4th ventricle - 3rd ventricle maintains its expected proportions without signs of enlargement - no findings suggestive of enlargement are seen in the external csf - the lateral ventricle shows no notable changes suggestive of enlargement For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears preserved, with no observable tissue loss	AD	We have the following subject's personal information: - The subject is a female of 71.2 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for shopping alone for clothes, household necessities, or groceries, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for playing a game of skill such as bridge or chess, working on a hobby, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject requires assitance for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, her total number of seconds to complete is 18. On the Trail Making Test Part B, her total number of seconds to complete is 42. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_941_S_7074_MR_Accelerated_Sagittal_MPRAGE__br_raw_20220608093519339_189_S1139524_I1588331	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the limbic cortex - insular cortex appears preserved, with no observable tissue loss - the parietal lobe shows no notable changes suggestive of atrophy - frontal lobe demonstrates a healthy morphology without signs of atrophy - occipital lobe appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the temporal lobe For the ventricles: - 3rd ventricle maintains its expected proportions without signs of enlargement - 4th ventricle appears within normal size limits with no apparent enlargement - inf. lateral ventricle maintains its expected proportions without signs of enlargement - no evident size increase noted in the lateral ventricle - no clear enlargement or abnormal growth seen in the external csf For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the hippocampus - amygdala appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the thalamus - mild atrophy of the right pallidum; the left pallidum is normal - no findings suggestive of atrophy are seen in the caudate - accumbens appears within normal limits without apparent atrophy - putamen appears preserved, with no observable tissue loss For additional Regions of Interest: - no appreciable degenerative or atrophic changes observed in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	CN	We have the following subject's personal information: - The subject is a male of 70.9 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 11. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203920149_02942_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178067	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the caudate - mild-to-moderate atrophy of the right pallidum; the left pallidum is normal - the accumbens shows no notable changes suggestive of atrophy - mild atrophy of the left thalamus; normal-to-mild atrophy of the right thalamus - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - no findings suggestive of atrophy are seen in the amygdala - mild bilateral atrophy of the putamen For the cerebral cortex: - frontal lobe maintains a normal appearance with no observable atrophic features - occipital lobe appears within normal limits without apparent atrophy - parietal lobe appears within normal limits without apparent atrophy - insular cortex appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the temporal lobe - no findings suggestive of atrophy are seen in the limbic cortex For the ventricles: - no appreciable enlargement noted in the external csf - inf. lateral ventricle maintains its expected proportions without signs of enlargement - no clear enlargement or abnormal growth seen in the 3rd ventricle - no evident size increase noted in the lateral ventricle - 4th ventricle maintains its expected proportions without signs of enlargement For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears preserved, with no observable tissue loss	BV	We have the following subject's personal information: - The subject is a male of 66.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 37 animals in 60 seconds. He named 17 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 27. - On the Number Span forward test, his longest span forward was 9. On the Number Span backward test, his longest span backward was 5. - On the Trail Making Test Part A, his total number of seconds to complete is 19, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 46, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in agitation or aggression, apathy or indifference, a moderate (significant, but not dramatic) change in depression or dysphoria, anxiety, disinhibition, irritability or lability, motor disturbance, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_033_S_10144_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20240710183736482_1_I10873175	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the 3rd ventricle - mild-to-moderate enlargement of the 4th ventricle - mild enlargement of the external csf - mild bilateral enlargement of the lateral ventricle - severe enlargement of the left inf. lateral ventricle and moderate-to-severe enlargement of the right inf. lateral ventricle For the subcortical structures: - the pallidum shows no notable changes suggestive of atrophy - mild atrophy of the right thalamus; the left thalamus is normal - no findings suggestive of atrophy are seen in the amygdala - no findings suggestive of atrophy are seen in the putamen - caudate demonstrates a healthy morphology without signs of atrophy - mild atrophy of the left accumbens; normal-to-mild atrophy of the right accumbens - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus For the cerebral cortex: - mild atrophy of the right parietal lobe; the left parietal lobe is normal; focal volume loss observed in the following subregions: supramarginal gyrus (normal on the left and mild-to-moderate atrophy on the right) and precuneus (normal on the left and mild atrophy on the right) - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild atrophy on the left and mild-to-moderate atrophy on the right) and central operculum (mild atrophy on the left and normal-to-mild atrophy on the right) - mild-to-moderate bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), opercular inf. frontal gyrus (normal on the left and mild atrophy on the right), precentral gyrus (mild atrophy on the left and normal on the right), triangular inf. frontal gyrus (mild atrophy on the right) and sup. frontal gyrus (mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the occipital lobe - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: fusiform gyrus (mild atrophy both left and right), transverse temporal gyrus (mild atrophy both left and right) and temporal pole (mild atrophy on the right) - mild atrophy of the left limbic cortex; the right limbic cortex is normal; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy on the left and normal on the right) and posterior cingulate gyrus (mild atrophy on the left and normal on the right) For additional Regions of Interest: - mild atrophy of the left speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) and mild-to-moderate atrophy of the right speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	AD	We have the following subject's personal information: - The subject is a female of 77.4 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following subject's family history information: - Her dad is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 20. In her MMSE test, she has an orientation to time score of 1. In her MMSE test, she has an orientation to place score of 2.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 5.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0217_MR_T1_mprage_S3_DIS3D_br_raw_20170817134937636_129_S598229_I891831	On a T1-weighted brain MRI we observed: For the ventricles: - no observable enlargement of the lateral ventricle - 4th ventricle appears to be of normal dimensions, with no observable increase in size - mild enlargement of the external csf - inf. lateral ventricle appears within normal size limits with no apparent enlargement - mild enlargement of the 3rd ventricle For the cerebral cortex: - limbic cortex appears preserved, with no observable tissue loss - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild atrophy both left and right) and central operculum (normal on the left and mild atrophy on the right) - frontal lobe appears preserved, with no observable tissue loss - occipital lobe appears within normal limits without apparent atrophy - parietal lobe appears within normal limits without apparent atrophy - temporal lobe maintains a normal appearance with no observable atrophic features For the subcortical structures: - no clear atrophic alterations are visible in the pallidum - amygdala maintains a normal appearance with no observable atrophic features - hippocampus demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the caudate - no evident atrophy or tissue thinning seen in the putamen - thalamus maintains a normal appearance with no observable atrophic features - accumbens demonstrates a healthy morphology without signs of atrophy For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	CN	We have the following subject's personal information: - The subject is a male of 56.0 years old. - He has 18.0 years of education (equivalent to master’s degree) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 28. - The subject has a Montreal Cognitive Assessment (MoCA) total score, corrected for education, of 26. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2.
FTLD_203822627_03722_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10451106	On a T1-weighted brain MRI we observed: For the subcortical structures: - accumbens appears preserved, with no observable tissue loss - pallidum appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the putamen - hippocampus maintains a normal appearance with no observable atrophic features - mild atrophy of the left thalamus; normal-to-mild atrophy of the right thalamus - no findings suggestive of atrophy are seen in the caudate - no clear atrophic alterations are visible in the amygdala For the ventricles: - no evident size increase noted in the inf. lateral ventricle - no observable enlargement of the 4th ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size - moderate enlargement of the external csf - mild enlargement of the 3rd ventricle For the cerebral cortex: - temporal lobe appears within normal limits without apparent atrophy - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: triangular inf. frontal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), middle frontal gyrus (mild atrophy both left and right), medial orbital gyrus (normal on the left and mild atrophy on the right) and supplementary motor cortex (normal on the left and mild atrophy on the right) - no evident atrophy or tissue thinning seen in the occipital lobe - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild atrophy both left and right) and frontal operculum (mild atrophy both left and right) - limbic cortex appears preserved, with no observable tissue loss - parietal lobe maintains a normal appearance with no observable atrophic features For additional Regions of Interest: - mild atrophy of the left speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) and mild-to-moderate atrophy of the right speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	CN	We have the following subject's personal information: - The subject is a male of 40.0 years old. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 26. - On the semantic categorical fluency test, the subject named 35 animals in 60 seconds. He named 12 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 15. - On the Number Span forward test, his longest span forward was 9. On the Number Span backward test, his longest span backward was 4. - On the Trail Making Test Part A, his total number of seconds to complete is 30, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 44, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in anxiety, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_037_S_0627_MR_MPR__GradWarp__N3__Scaled_Br_20071030172722998_S16313_I79831	On a T1-weighted brain MRI we observed: For the cerebral cortex: - insular cortex demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the parietal lobe - no observable atrophic changes in the temporal lobe - mild atrophy of the left occipital lobe; the right occipital lobe is normal; focal volume loss observed in the following subregions: sup. occipital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) and occipital fusiform gyrus (mild atrophy on the left) - no observable atrophic changes in the frontal lobe - no findings suggestive of atrophy are seen in the limbic cortex For the subcortical structures: - caudate maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the accumbens - mild bilateral atrophy of the amygdala - mild-to-moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - no observable atrophic changes in the pallidum - thalamus maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the putamen For the ventricles: - no evident size increase noted in the 3rd ventricle - no appreciable enlargement noted in the external csf - 4th ventricle appears within normal size limits with no apparent enlargement - mild-to-moderate enlargement of the left inf. lateral ventricle; the right inf. lateral ventricle is normal - mild bilateral enlargement of the lateral ventricle For additional Regions of Interest: - no appreciable degenerative or atrophic changes observed in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	AD	We have the following subject's personal information: - The subject is a female of 58.6 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 23. In her MMSE test, she has an orientation to time score of 3. In her MMSE test, she has an orientation to place score of 2.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 5.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
FTLD_203709993_03390_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10450653	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no evident atrophy or tissue thinning seen in the limbic cortex - temporal lobe maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the insular cortex - the frontal lobe shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the parietal lobe - occipital lobe appears preserved, with no observable tissue loss For the ventricles: - 3rd ventricle appears within normal size limits with no apparent enlargement - external csf maintains its expected proportions without signs of enlargement - no appreciable enlargement noted in the inf. lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - no appreciable enlargement noted in the lateral ventricle For the subcortical structures: - no observable atrophic changes in the amygdala - mild bilateral atrophy of the putamen - no appreciable degenerative or atrophic changes observed in the hippocampus - mild atrophy of the left accumbens; the right accumbens is normal - thalamus appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the caudate - pallidum appears within normal limits without apparent atrophy For additional Regions of Interest: - the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a female of 47.0 years old. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 29. - On the semantic categorical fluency test, the subject named 23 animals in 60 seconds. She named 12 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 29. - On the Number Span forward test, her longest span forward was 7. On the Number Span backward test, her longest span backward was 8. - On the Trail Making Test Part A, her total number of seconds to complete is 20, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 47, her number of commission errors is 0, her number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_016_S_5251_MR_Accelerated_SAG_IR-SPGR__br_raw_20130814141948383_107_S197579_I385048	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the thalamus - mild-to-moderate atrophy of the right amygdala; normal-to-mild atrophy of the left amygdala - no evident atrophy or tissue thinning seen in the hippocampus - mild-to-moderate atrophy of the left accumbens and mild atrophy of the right accumbens - mild bilateral atrophy of the pallidum - no clear atrophic alterations are visible in the caudate - no findings suggestive of atrophy are seen in the putamen For the cerebral cortex: - mild atrophy of the right parietal lobe; normal-to-mild atrophy of the left parietal lobe; focal volume loss observed in the following subregions: postcentral gyrus (mild atrophy on the left and normal on the right) and precuneus (mild atrophy on the left and normal on the right) - no evident atrophy or tissue thinning seen in the temporal lobe - no clear atrophic alterations are visible in the occipital lobe - frontal lobe appears within normal limits without apparent atrophy - limbic cortex appears within normal limits without apparent atrophy - insular cortex appears within normal limits without apparent atrophy For the ventricles: - mild enlargement of the 4th ventricle - no appreciable enlargement noted in the external csf - mild bilateral enlargement of the lateral ventricle - moderate enlargement of the 3rd ventricle - mild enlargement of the left inf. lateral ventricle; the right inf. lateral ventricle is normal For additional Regions of Interest: - no clear atrophic alterations are visible in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	AD	We have the following subject's personal information: - The subject is a female of 66.2 years old. - Subject's current marrietal status is: married. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following subject's health history information: - She has quit smoking at the age of 33.She smoked a pack to a pack and a half a day. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 26. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 1. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0145_MR_T1_mprage_S7_DIS3D_br_raw_20170817100405763_97_S597290_I890597	On a T1-weighted brain MRI we observed: For the cerebral cortex: - moderate atrophy of the left temporal lobe and mild-to-moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: fusiform gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), inf. temporal gyrus (normal on the left and mild-to-moderate atrophy on the right), sup. temporal gyrus (mild-to-moderate atrophy on the left and normal on the right), temporal pole (mild atrophy on the left and normal-to-mild atrophy on the right), middle temporal gyrus (mild atrophy on the left and normal on the right) and planum temporale (mild atrophy on the left) - no observable atrophic changes in the frontal lobe - the parietal lobe shows no notable changes suggestive of atrophy - moderate atrophy of the left insular cortex and mild-to-moderate atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (moderate atrophy on the left and mild-to-moderate atrophy on the right), posterior insula (mild atrophy both left and right), frontal operculum (normal on the left and mild-to-moderate atrophy on the right) and parietal operculum (mild-to-moderate atrophy on the left) - mild atrophy of the left limbic cortex and mild-to-moderate atrophy of the right limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), entorhinal area (mild atrophy both left and right) and middle cingulate gyrus (mild atrophy on the left and normal on the right) - no evident atrophy or tissue thinning seen in the occipital lobe For the subcortical structures: - moderate atrophy of the left caudate and moderate-to-severe atrophy of the right caudate - moderate bilateral atrophy of the putamen - moderate-to-severe atrophy of the left accumbens and severe atrophy of the right accumbens - moderate atrophy of the left hippocampus, moderate atrophy of the right hippocampus - mild bilateral atrophy of the thalamus - severe bilateral atrophy of the amygdala - mild bilateral atrophy of the pallidum For the ventricles: - moderate enlargement of the left lateral ventricle and moderate-to-severe enlargement of the right lateral ventricle - severe enlargement of the 3rd ventricle - 4th ventricle maintains its expected proportions without signs of enlargement - severe bilateral enlargement of the inf. lateral ventricle - mild enlargement of the external csf For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) demonstrates a healthy morphology without signs of atrophy	BV	We have the following subject's personal information: - The subject is a male of 57.0 years old. - He has 14.0 years of education We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 24. - The subject has a Montreal Cognitive Assessment (MoCA) total score, corrected for education, of 17. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Functional Activities Questionnaire (FAQ), the subject requires assitance for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in elation or euphoria, apathy or indifference, irritability or lability, motor disturbance, appetite and eating, a moderate (significant, but not dramatic) change in agitation or aggression. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 7.0. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
ADNI_003_S_10082_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20240508180659124_1_I10454163	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the 4th ventricle - mild enlargement of the left inf. lateral ventricle; the right inf. lateral ventricle is normal - no evident size increase noted in the 3rd ventricle - mild enlargement of the left lateral ventricle; the right lateral ventricle is normal - mild enlargement of the external csf For the subcortical structures: - no evident atrophy or tissue thinning seen in the thalamus - no appreciable degenerative or atrophic changes observed in the caudate - hippocampus demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the accumbens - mild atrophy of the left putamen; the right putamen is normal - mild atrophy of the left pallidum; the right pallidum is normal - the amygdala shows no notable changes suggestive of atrophy For the cerebral cortex: - the limbic cortex shows no notable changes suggestive of atrophy - temporal lobe maintains a normal appearance with no observable atrophic features - mild atrophy of the right insular cortex; the left insular cortex is normal; focal volume loss observed in the following subregions: anterior insula (mild atrophy both left and right) and posterior insula (mild atrophy both left and right) - the frontal lobe shows no notable changes suggestive of atrophy - parietal lobe maintains a normal appearance with no observable atrophic features - occipital lobe appears within normal limits without apparent atrophy For additional Regions of Interest: - no clear atrophic alterations are visible in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	CN	We have the following subject's personal information: - The subject is a female of 75.2 years old. - Subject's current marrietal status is: married. - She has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following subject's family history information: - Her dad is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 10. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203551893_02395_MR_Sagittal_MP-Rage_br_raw_20230124212843779_I10178656	On a T1-weighted brain MRI we observed: For the subcortical structures: - hippocampus appears within normal limits without apparent atrophy - caudate maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the thalamus - no findings suggestive of atrophy are seen in the amygdala - putamen appears preserved, with no observable tissue loss - no observable atrophic changes in the accumbens - pallidum maintains a normal appearance with no observable atrophic features For the ventricles: - no appreciable enlargement noted in the external csf - lateral ventricle appears within normal size limits with no apparent enlargement - no evident size increase noted in the 4th ventricle - no observable enlargement of the inf. lateral ventricle - no clear enlargement or abnormal growth seen in the 3rd ventricle For the cerebral cortex: - no observable atrophic changes in the limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) - frontal lobe maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the occipital lobe - the parietal lobe shows no notable changes suggestive of atrophy - insular cortex appears within normal limits without apparent atrophy - temporal lobe appears preserved, with no observable tissue loss For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a male of 38.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is left-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 28. - On the semantic categorical fluency test, the subject named 17 animals in 60 seconds. He named 12 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 10. - On the Number Span forward test, his longest span forward was 4. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 22, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 71, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in depression or dysphoria, anxiety, apathy or indifference, motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_032_S_0677_MR_MPR____N3__Scaled_Br_20070123200558482_S16051_I37228	On a T1-weighted brain MRI we observed: For the cerebral cortex: - the occipital lobe shows no notable changes suggestive of atrophy - the frontal lobe shows no notable changes suggestive of atrophy - parietal lobe appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the insular cortex - mild atrophy of the right limbic cortex; the left limbic cortex is normal; focal volume loss observed in the following subregions: entorhinal area (normal on the left and mild atrophy on the right) - temporal lobe appears preserved, with no observable tissue loss For the subcortical structures: - putamen demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the pallidum - accumbens appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the amygdala - caudate appears preserved, with no observable tissue loss - thalamus maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the hippocampus For the ventricles: - lateral ventricle appears to be of normal dimensions, with no observable increase in size - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - no clear enlargement or abnormal growth seen in the 4th ventricle - external csf maintains its expected proportions without signs of enlargement - the inf. lateral ventricle shows no notable changes suggestive of enlargement For additional Regions of Interest: - no appreciable degenerative or atrophic changes observed in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	CN	We have the following subject's personal information: - The subject is a male of 70.9 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 28. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 12. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_027_S_1081_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070327152141858_S25357_I47168	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild atrophy of the right caudate; the left caudate is normal - mild atrophy of the right pallidum; the left pallidum is normal - moderate atrophy of the left hippocampus, mild atrophy of the right hippocampus - moderate bilateral atrophy of the amygdala - mild atrophy of the right accumbens; normal-to-mild atrophy of the left accumbens - mild-to-moderate atrophy of the right putamen; the left putamen is normal - mild atrophy of the right thalamus; normal-to-mild atrophy of the left thalamus For the ventricles: - 4th ventricle maintains its expected proportions without signs of enlargement - moderate bilateral enlargement of the inf. lateral ventricle - mild enlargement of the external csf - mild-to-moderate bilateral enlargement of the lateral ventricle - 3rd ventricle maintains a typical volume without observable enlargement For the cerebral cortex: - mild atrophy of the left occipital lobe and moderate atrophy of the right occipital lobe; focal volume loss observed in the following subregions: cuneus (normal on the left and mild-to-moderate atrophy on the right), middle occipital gyrus (normal on the left and mild-to-moderate atrophy on the right) and lingual gyrus (normal on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the insular cortex - mild-to-moderate atrophy of the right limbic cortex; the left limbic cortex is normal; focal volume loss observed in the following subregions: entorhinal area (mild atrophy on the left and mild-to-moderate atrophy on the right), anterior cingulate gyrus (normal on the left and mild-to-moderate atrophy on the right) and parahippocampal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) - frontal lobe maintains a normal appearance with no observable atrophic features - mild atrophy of the left temporal lobe; the right temporal lobe is normal; focal volume loss observed in the following subregions: fusiform gyrus (mild atrophy both left and right), temporal pole (mild atrophy both left and right) and inf. temporal gyrus (mild atrophy on the left) - parietal lobe appears preserved, with no observable tissue loss For additional Regions of Interest: - mild atrophy of the left speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex); normal-to-mild atrophy of the right speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	AD	We have the following subject's personal information: - The subject is a male of 84.6 years old. - Subject's current marrietal status is: married. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 23. In his MMSE test, he has an orientation to time score of 3. In his MMSE test, he has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 7.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0013_MR_T1_MPRAGE_long_S4_DIS3D__br_raw_20110204153537827_10_S99076_I216017	On a T1-weighted brain MRI we observed: For the cerebral cortex: - severe atrophy of the left temporal lobe; the right temporal lobe is normal; focal volume loss observed in the following subregions: temporal pole (moderate-to-severe atrophy on the left), inf. temporal gyrus (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right), fusiform gyrus (mild atrophy on the left), planum polare (mild atrophy on the left and normal-to-mild atrophy on the right), middle temporal gyrus (mild-to-moderate atrophy on the left), transverse temporal gyrus (mild atrophy on the left and normal on the right) and sup. temporal gyrus (mild atrophy on the left) - mild atrophy of the left occipital lobe; the right occipital lobe is normal; focal volume loss observed in the following subregions: calcarine cortex (mild atrophy on the left and normal-to-mild atrophy on the right), cuneus (mild atrophy on the left and normal on the right) and lingual gyrus (mild atrophy on the left) - mild atrophy of the left insular cortex; the right insular cortex is normal; focal volume loss observed in the following subregions: central operculum (normal-to-mild atrophy on the left and mild atrophy on the right), anterior insula (mild-to-moderate atrophy on the left) and posterior insula (mild atrophy on the left) - moderate atrophy of the left limbic cortex; the right limbic cortex is normal; focal volume loss observed in the following subregions: entorhinal area (mild-to-moderate atrophy on the left and normal on the right), parahippocampal gyrus (mild-to-moderate atrophy on the left), anterior cingulate gyrus (mild atrophy on the left and normal on the right) and posterior cingulate gyrus (mild atrophy on the left and normal on the right) - no findings suggestive of atrophy are seen in the frontal lobe - parietal lobe appears preserved, with no observable tissue loss For the ventricles: - no findings suggestive of enlargement are seen in the 3rd ventricle - external csf maintains a typical volume without observable enlargement - 4th ventricle appears to be of normal dimensions, with no observable increase in size - severe enlargement of the left inf. lateral ventricle; the right inf. lateral ventricle is normal - mild enlargement of the left lateral ventricle; the right lateral ventricle is normal For the subcortical structures: - severe atrophy of the left amygdala; the right amygdala is normal - no clear atrophic alterations are visible in the putamen - moderate atrophy of the left hippocampus - accumbens maintains a normal appearance with no observable atrophic features - caudate maintains a normal appearance with no observable atrophic features - pallidum appears within normal limits without apparent atrophy - thalamus maintains a normal appearance with no observable atrophic features For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) demonstrates a healthy morphology without signs of atrophy	SV	We have the following subject's personal information: - The subject is a male of 61.0 years old. - He has 18.0 years of education (equivalent to master’s degree) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications. The subject has difficulity, but does by himself, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in agitation or aggression, depression or dysphoria, anxiety, apathy or indifference, irritability or lability, motor disturbance, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 1.5. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
ADNI_099_S_6016_MR_Accelerated_Sag_IR-FSPGR___br_raw_20170607105839338_156_S571311_I859714	On a T1-weighted brain MRI we observed: For the subcortical structures: - hippocampus demonstrates a healthy morphology without signs of atrophy - mild atrophy of the right accumbens; the left accumbens is normal - no observable atrophic changes in the amygdala - mild bilateral atrophy of the thalamus - no findings suggestive of atrophy are seen in the caudate - mild bilateral atrophy of the putamen - pallidum maintains a normal appearance with no observable atrophic features For the ventricles: - moderate enlargement of the left inf. lateral ventricle and mild enlargement of the right inf. lateral ventricle - severe enlargement of the left lateral ventricle and moderate enlargement of the right lateral ventricle - external csf maintains a typical volume without observable enlargement - mild-to-moderate enlargement of the 3rd ventricle - severe enlargement of the 4th ventricle For the cerebral cortex: - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (mild atrophy both left and right), lingual gyrus (normal on the left and mild-to-moderate atrophy on the right), inf. occipital gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), occipital pole (normal-to-mild atrophy on the left and mild atrophy on the right) and cuneus (normal on the left and mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the frontal lobe - parietal lobe appears preserved, with no observable tissue loss - limbic cortex demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild-to-moderate atrophy both left and right) and parietal operculum (mild atrophy on the left) - temporal lobe demonstrates a healthy morphology without signs of atrophy For additional Regions of Interest: - mild atrophy of the right speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex); the left speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) is normal	CN	We have the following subject's personal information: - The subject is a female of 65.6 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 8. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203575598_02897_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10177141	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the amygdala - caudate maintains a normal appearance with no observable atrophic features - the pallidum shows no notable changes suggestive of atrophy - the thalamus shows no notable changes suggestive of atrophy - accumbens appears within normal limits without apparent atrophy - mild atrophy of the left putamen; the right putamen is normal - no clear atrophic alterations are visible in the hippocampus For the ventricles: - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - inf. lateral ventricle maintains a typical volume without observable enlargement - lateral ventricle appears to be of normal dimensions, with no observable increase in size - no appreciable enlargement noted in the 4th ventricle - no observable enlargement of the external csf For the cerebral cortex: - limbic cortex appears preserved, with no observable tissue loss - mild atrophy of the right insular cortex; normal-to-mild atrophy of the left insular cortex; focal volume loss observed in the following subregions: posterior insula (mild atrophy on the left and normal-to-mild atrophy on the right) and parietal operculum (mild atrophy on the left and normal on the right) - no evident atrophy or tissue thinning seen in the frontal lobe - parietal lobe appears within normal limits without apparent atrophy - occipital lobe appears preserved, with no observable tissue loss - temporal lobe maintains a normal appearance with no observable atrophic features For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a female of 44.0 years old. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 24 animals in 60 seconds. She named 17 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 22. - On the Number Span forward test, her longest span forward was 7. On the Number Span backward test, her longest span backward was 3. - On the Trail Making Test Part A, her total number of seconds to complete is 28, her number of commission errors is 1, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 68, her number of commission errors is 2, her number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
FTLD_203479335_01537_MR_Sagittal_MP-Rage_br_raw_20230206173239686_I10182122	On a T1-weighted brain MRI we observed: For the ventricles: - moderate enlargement of the external csf - no evident size increase noted in the 4th ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - moderate enlargement of the left inf. lateral ventricle and severe enlargement of the right inf. lateral ventricle - mild-to-moderate enlargement of the left lateral ventricle and mild enlargement of the right lateral ventricle For the cerebral cortex: - no findings suggestive of atrophy are seen in the insular cortex - moderate atrophy of the right temporal lobe; the left temporal lobe is normal; focal volume loss observed in the following subregions: middle temporal gyrus (mild atrophy on the left and moderate atrophy on the right), temporal pole (mild atrophy on the left and moderate atrophy on the right), planum polare (normal on the left and mild-to-moderate atrophy on the right) and inf. temporal gyrus (mild atrophy on the right) - occipital lobe appears preserved, with no observable tissue loss - mild-to-moderate atrophy of the right frontal lobe; normal-to-mild atrophy of the left frontal lobe; focal volume loss observed in the following subregions: precentral gyrus medial segment (mild atrophy on the right), frontal pole (mild atrophy on the left and normal-to-mild atrophy on the right), triangular inf. frontal gyrus (mild-to-moderate atrophy on the left), precentral gyrus (normal on the left and mild atrophy on the right), sup. frontal gyrus (normal on the left and mild atrophy on the right) and orbital inf. frontal gyrus (mild atrophy on the right) - no clear atrophic alterations are visible in the parietal lobe - mild-to-moderate atrophy of the left limbic cortex and moderate atrophy of the right limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy on the left and moderate atrophy on the right), parahippocampal gyrus (mild atrophy both left and right), posterior cingulate gyrus (mild atrophy both left and right) and entorhinal area (normal on the left and mild-to-moderate atrophy on the right) For the subcortical structures: - mild-to-moderate atrophy of the left hippocampus, moderate-to-severe atrophy of the right hippocampus - moderate atrophy of the left amygdala and severe atrophy of the right amygdala - mild atrophy of the left pallidum and mild-to-moderate atrophy of the right pallidum - moderate bilateral atrophy of the accumbens - mild-to-moderate atrophy of the left caudate and moderate atrophy of the right caudate - mild-to-moderate atrophy of the left putamen and moderate atrophy of the right putamen - mild-to-moderate atrophy of the right thalamus; the left thalamus is normal For additional Regions of Interest: - mild bilateral atrophy of the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	BV	We have the following subject's personal information: - The subject is a female of 74.0 years old. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 26. - On the semantic categorical fluency test, the subject named 18 animals in 60 seconds. She named 16 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 13. - On the Number Span forward test, her longest span forward was 7. On the Number Span backward test, her longest span backward was 5. - On the Trail Making Test Part A, her total number of seconds to complete is 23, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 61, her number of commission errors is 0, her number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in disinhibition, a moderate (significant, but not dramatic) change in elation or euphoria, apathy or indifference, irritability or lability, appetite and eating, a mild (noticeable, but not significant) change in delusions, anxiety, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.5 (questionnable impairment). Description: Consistent mild word-finding difficulties; simplification of word choice; circumlocution; decreased phrase length; and/or mild comprehension difficulties.
FTLD_203415713_03311_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10176817	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the right lateral ventricle; the left lateral ventricle is normal - 3rd ventricle appears within normal size limits with no apparent enlargement - moderate enlargement of the external csf - moderate-to-severe enlargement of the left inf. lateral ventricle and severe enlargement of the right inf. lateral ventricle - no clear enlargement or abnormal growth seen in the 4th ventricle For the subcortical structures: - no evident atrophy or tissue thinning seen in the thalamus - mild-to-moderate atrophy of the left accumbens and moderate atrophy of the right accumbens - mild atrophy of the left putamen and mild-to-moderate atrophy of the right putamen - severe bilateral atrophy of the amygdala - moderate atrophy of the left hippocampus, moderate-to-severe atrophy of the right hippocampus - mild atrophy of the left caudate and moderate atrophy of the right caudate - mild atrophy of the right pallidum; the left pallidum is normal For the cerebral cortex: - severe bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: temporal pole (moderate-to-severe atrophy on the left and severe atrophy on the right), inf. temporal gyrus (moderate atrophy on the left and moderate-to-severe atrophy on the right), fusiform gyrus (mild-to-moderate atrophy on the left and moderate atrophy on the right), middle temporal gyrus (mild atrophy on the left and moderate-to-severe atrophy on the right) and sup. temporal gyrus (mild atrophy both left and right) - parietal lobe maintains a normal appearance with no observable atrophic features - mild-to-moderate atrophy of the left limbic cortex and moderate atrophy of the right limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild-to-moderate atrophy both left and right), parahippocampal gyrus (mild-to-moderate atrophy both left and right), anterior cingulate gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right) and posterior cingulate gyrus (mild atrophy both left and right) - the frontal lobe shows no notable changes suggestive of atrophy - no findings suggestive of atrophy are seen in the occipital lobe - mild-to-moderate atrophy of the right insular cortex; the left insular cortex is normal; focal volume loss observed in the following subregions: posterior insula (moderate atrophy both left and right), anterior insula (mild atrophy on the left and mild-to-moderate atrophy on the right) and frontal operculum (mild atrophy on the right) For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears within normal limits without apparent atrophy	BV	We have the following subject's personal information: - The subject is a female of 65.0 years old. - She has 14.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 4. - On the semantic categorical fluency test, the subject named 5 animals in 60 seconds. She named 1 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 8. - On the Number Span forward test, her longest span forward was 5. On the Number Span backward test, her longest span backward was 3. - On the Trail Making Test Part A, her total number of seconds to complete is 62, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 125, her number of commission errors is 0, her number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in delusions, hallucinations, anxiety, elation or euphoria, a moderate (significant, but not dramatic) change in disinhibition, irritability or lability, motor disturbance, appetite and eating, a mild (noticeable, but not significant) change in agitation or aggression. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. Her standard CDR Sum of Boxes score is 10.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 2.0 (moderate impairment). Description: Severely impaired in handling problems, similarities, and differences; social judgment usually impaired. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 2.0 (moderate impairment). Description: Requires much help with personal care; frequent incontinence. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
FTLD_203945852_01254_MR_Sagittal_MP-Rage_br_raw_20230124210916522_I10178544	On a T1-weighted brain MRI we observed: For the subcortical structures: - no observable atrophic changes in the putamen - mild atrophy of the right amygdala; normal-to-mild atrophy of the left amygdala - mild atrophy of the left accumbens; the right accumbens is normal - no observable atrophic changes in the hippocampus - thalamus maintains a normal appearance with no observable atrophic features - no observable atrophic changes in the caudate - pallidum maintains a normal appearance with no observable atrophic features For the ventricles: - no evident size increase noted in the inf. lateral ventricle - mild enlargement of the 3rd ventricle - mild enlargement of the external csf - mild bilateral enlargement of the lateral ventricle - severe enlargement of the 4th ventricle For the cerebral cortex: - mild atrophy of the left limbic cortex; normal-to-mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and middle cingulate gyrus (mild atrophy on the left and normal on the right) - no appreciable degenerative or atrophic changes observed in the frontal lobe - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: planum temporale (moderate atrophy on the left and normal on the right), temporal pole (mild atrophy both left and right), transverse temporal gyrus (normal on the left and mild atrophy on the right) and middle temporal gyrus (mild atrophy on the left and normal on the right) - parietal lobe maintains a normal appearance with no observable atrophic features - mild atrophy of the right insular cortex; the left insular cortex is normal; focal volume loss observed in the following subregions: central operculum (normal on the left and mild atrophy on the right) - no findings suggestive of atrophy are seen in the occipital lobe For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a female of 57.0 years old. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is left-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 14 animals in 60 seconds. She named 18 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 19. - On the Number Span forward test, her longest span forward was 7. On the Number Span backward test, her longest span backward was 6. - On the Trail Making Test Part A, her total number of seconds to complete is 18, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 48, her number of commission errors is 0, her number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_114_S_6039_MR__br_raw_20190820093029061_120_S587860_I879209	On a T1-weighted brain MRI we observed: For the cerebral cortex: - the occipital lobe shows no notable changes suggestive of atrophy - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right) and middle temporal gyrus (normal on the left and mild atrophy on the right) - limbic cortex demonstrates a healthy morphology without signs of atrophy - moderate atrophy of the left parietal lobe and mild atrophy of the right parietal lobe; focal volume loss observed in the following subregions: precuneus (mild atrophy both left and right), angular gyrus (mild-to-moderate atrophy on the left and normal on the right), sup. parietal lobule (mild-to-moderate atrophy on the left and normal on the right) and supramarginal gyrus (mild atrophy on the left) - mild atrophy of the left frontal lobe; normal-to-mild atrophy of the right frontal lobe; focal volume loss observed in the following subregions: sup. frontal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), lateral orbital gyrus (mild atrophy on the left and normal on the right), precentral gyrus medial segment (mild atrophy on the left and normal on the right), triangular inf. frontal gyrus (mild atrophy on the right) and middle frontal gyrus (mild atrophy on the left) - insular cortex appears preserved, with no observable tissue loss For the subcortical structures: - mild bilateral atrophy of the putamen - hippocampus appears within normal limits without apparent atrophy - caudate appears within normal limits without apparent atrophy - mild bilateral atrophy of the accumbens - no appreciable degenerative or atrophic changes observed in the pallidum - amygdala maintains a normal appearance with no observable atrophic features - thalamus maintains a normal appearance with no observable atrophic features For the ventricles: - no observable enlargement of the inf. lateral ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size - 4th ventricle appears within normal size limits with no apparent enlargement - moderate enlargement of the external csf - no findings suggestive of enlargement are seen in the 3rd ventricle For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears preserved, with no observable tissue loss	AD	We have the following subject's personal information: - The subject is a male of 56.0 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 22. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications. The subject has difficulity, but does by himself, for assembling tax records, business affairs, or other paper. The subject requires assitance for writing checks, paying bills, or balancing a checkbook, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 150. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_012_S_4545_MR_MPRAGE_SENSE2__br_raw_20120315112934375_1_S143908_I290409	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the insular cortex - no clear atrophic alterations are visible in the temporal lobe - frontal lobe appears within normal limits without apparent atrophy - no findings suggestive of atrophy are seen in the parietal lobe - occipital lobe maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the limbic cortex For the subcortical structures: - hippocampus demonstrates a healthy morphology without signs of atrophy - mild bilateral atrophy of the pallidum - no evident atrophy or tissue thinning seen in the putamen - caudate demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the amygdala - no findings suggestive of atrophy are seen in the thalamus - no clear atrophic alterations are visible in the accumbens For the ventricles: - the inf. lateral ventricle shows no notable changes suggestive of enlargement - 4th ventricle maintains a typical volume without observable enlargement - no evident size increase noted in the lateral ventricle - the external csf shows no notable changes suggestive of enlargement - no findings suggestive of enlargement are seen in the 3rd ventricle For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) demonstrates a healthy morphology without signs of atrophy	CN	We have the following subject's personal information: - The subject is a female of 67.1 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 30. - On the semantic categorical fluency test, the subject named 27 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 21. On the Trail Making Test Part B, her total number of seconds to complete is 38. From genetic data, APOE genotype is e3,e2 with no e4 allele.
ADNI_016_S_6839_MR_Accelerated_Sagittal_MPRAGE__br_raw_20191207184545003_53_S902460_I1263249	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild-to-moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - mild-to-moderate atrophy of the left pallidum; the right pallidum is normal - mild-to-moderate atrophy of the left thalamus and mild atrophy of the right thalamus - mild-to-moderate atrophy of the left accumbens and mild atrophy of the right accumbens - mild atrophy of the left caudate; the right caudate is normal - moderate atrophy of the left putamen and mild-to-moderate atrophy of the right putamen - moderate atrophy of the left amygdala and mild-to-moderate atrophy of the right amygdala For the ventricles: - moderate-to-severe enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - mild-to-moderate enlargement of the external csf - moderate bilateral enlargement of the lateral ventricle - mild enlargement of the 4th ventricle - moderate enlargement of the 3rd ventricle For the cerebral cortex: - no findings suggestive of atrophy are seen in the occipital lobe - no observable atrophic changes in the insular cortex - no findings suggestive of atrophy are seen in the parietal lobe - mild atrophy of the left temporal lobe; the right temporal lobe is normal; focal volume loss observed in the following subregions: middle temporal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), temporal pole (mild atrophy on the left and normal on the right) and fusiform gyrus (mild atrophy on the left) - no findings suggestive of atrophy are seen in the frontal lobe - mild atrophy of the left limbic cortex; the right limbic cortex is normal; focal volume loss observed in the following subregions: entorhinal area (mild atrophy both left and right) and anterior cingulate gyrus (mild-to-moderate atrophy on the left and normal on the right) For additional Regions of Interest: - the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) shows no notable changes suggestive of atrophy	AD	We have the following subject's personal information: - The subject is a female of 70.3 years old. - Subject's current marrietal status is: married. - She has 17.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 23. In her MMSE test, she has an orientation to time score of 4. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 2. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 3.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_021_S_10293_MR_Accelerated_Sag_IR-FSPGR_MSV21_br_raw_20241025184353116_1_I10989652	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the accumbens - hippocampus maintains a normal appearance with no observable atrophic features - amygdala appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the thalamus - putamen maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the caudate - no clear atrophic alterations are visible in the pallidum For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the insular cortex - limbic cortex demonstrates a healthy morphology without signs of atrophy - no appreciable degenerative or atrophic changes observed in the parietal lobe - no findings suggestive of atrophy are seen in the frontal lobe - mild atrophy of the left occipital lobe; the right occipital lobe is normal; focal volume loss observed in the following subregions: lingual gyrus (moderate atrophy on the left and mild atrophy on the right), cuneus (normal on the left and mild atrophy on the right) and sup. occipital gyrus (mild atrophy on the left) - no clear atrophic alterations are visible in the temporal lobe For the ventricles: - external csf maintains its expected proportions without signs of enlargement - no observable enlargement of the 4th ventricle - the inf. lateral ventricle shows no notable changes suggestive of enlargement - no clear enlargement or abnormal growth seen in the 3rd ventricle - no evident size increase noted in the lateral ventricle For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	CN	We have the following subject's personal information: - The subject is a female of 67.7 years old. - Subject's current marrietal status is: divorced. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following subject's family history information: - One of Her first degree family member (sibling or child) is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 16. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_129_S_4422_MR_Accelerated_Sag_IR-FSPGR___br_raw_20180319093631811_61_S667848_I974779	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no findings suggestive of atrophy are seen in the frontal lobe - no findings suggestive of atrophy are seen in the occipital lobe - no findings suggestive of atrophy are seen in the parietal lobe - mild atrophy of the left temporal lobe and severe atrophy of the right temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild atrophy on the left and moderate atrophy on the right), inf. temporal gyrus (mild atrophy on the left and moderate atrophy on the right), fusiform gyrus (normal on the left and mild-to-moderate atrophy on the right), planum polare (normal on the left and mild-to-moderate atrophy on the right), middle temporal gyrus (normal on the left and mild-to-moderate atrophy on the right) and sup. temporal gyrus (mild atrophy on the right) - mild-to-moderate atrophy of the right limbic cortex; the left limbic cortex is normal; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy both left and right), entorhinal area (normal on the left and mild-to-moderate atrophy on the right) and parahippocampal gyrus (normal on the left and mild atrophy on the right) - mild-to-moderate atrophy of the right insular cortex; the left insular cortex is normal; focal volume loss observed in the following subregions: anterior insula (normal-to-mild atrophy on the left and moderate atrophy on the right) and posterior insula (mild-to-moderate atrophy on the right) For the ventricles: - moderate enlargement of the external csf - moderate enlargement of the 3rd ventricle - mild enlargement of the left lateral ventricle and moderate enlargement of the right lateral ventricle - mild enlargement of the 4th ventricle - severe bilateral enlargement of the inf. lateral ventricle For the subcortical structures: - mild atrophy of the right putamen; the left putamen is normal - mild-to-moderate atrophy of the left hippocampus, severe atrophy of the right hippocampus - mild atrophy of the left thalamus and moderate atrophy of the right thalamus - mild atrophy of the right caudate; the left caudate is normal - mild-to-moderate atrophy of the left amygdala and severe atrophy of the right amygdala - mild-to-moderate atrophy of the right accumbens; the left accumbens is normal - mild atrophy of the right pallidum; the left pallidum is normal For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	AD	We have the following subject's personal information: - The subject is a female of 77.1 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 24. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 2.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 5. - The subject has a 32-item Multilingual Naming Test (MINT) total score of 21. - On the semantic categorical fluency test, the subject named 8 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 7. - On the Functional Activities Questionnaire (FAQ), the subject has difficulity, but does by himself, for shopping alone for clothes, household necessities, or groceries, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for remembering appointments, family occasions, holidays, medications. The subject requires assitance for writing checks, paying bills, or balancing a checkbook, for playing a game of skill such as bridge or chess, working on a hobby, for preparing a balanced meal, for paying attention to and understanding a TV program, book, or magazine. The subject is dependent for assembling tax records, business affairs, or other paper, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 40. On the Trail Making Test Part B, her total number of seconds to complete is 87. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 5.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e2 with no e4 allele.
ADNI_941_S_10023_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20231204181620142_1_I10298439	On a T1-weighted brain MRI we observed: For the cerebral cortex: - moderate atrophy of the left occipital lobe and mild-to-moderate atrophy of the right occipital lobe; focal volume loss observed in the following subregions: inf. occipital gyrus (mild-to-moderate atrophy both left and right), lingual gyrus (mild atrophy both left and right), sup. occipital gyrus (mild-to-moderate atrophy on the left and normal on the right) and middle occipital gyrus (mild atrophy on the left) - moderate atrophy of the left temporal lobe and mild-to-moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: middle temporal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), inf. temporal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), temporal pole (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), fusiform gyrus (normal on the left and mild atrophy on the right) and transverse temporal gyrus (mild atrophy on the left) - no clear atrophic alterations are visible in the limbic cortex - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (mild-to-moderate atrophy on the left and mild atrophy on the right) and frontal operculum (mild atrophy on the left) - no findings suggestive of atrophy are seen in the frontal lobe - no findings suggestive of atrophy are seen in the parietal lobe For the subcortical structures: - caudate maintains a normal appearance with no observable atrophic features - accumbens appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the pallidum - moderate atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - no appreciable degenerative or atrophic changes observed in the thalamus - no clear atrophic alterations are visible in the putamen - moderate atrophy of the left amygdala and mild-to-moderate atrophy of the right amygdala For the ventricles: - 4th ventricle maintains a typical volume without observable enlargement - 3rd ventricle maintains a typical volume without observable enlargement - no clear enlargement or abnormal growth seen in the external csf - lateral ventricle appears within normal size limits with no apparent enlargement - no appreciable enlargement noted in the inf. lateral ventricle For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	AD	We have the following subject's personal information: - The subject is a female of 71.4 years old. - Subject's current marrietal status is: living as married. - She has 17.0 years of education - The subject is left-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 24. In her MMSE test, she has an orientation to time score of 1. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 0. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 3.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203234203_02303_MR_Sagittal_MP-Rage_br_raw_20230124212746027_I10178649	On a T1-weighted brain MRI we observed: For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the putamen - no findings suggestive of atrophy are seen in the hippocampus - pallidum appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the thalamus - mild atrophy of the left accumbens; the right accumbens is normal - no observable atrophic changes in the amygdala - mild atrophy of the right caudate; the left caudate is normal For the cerebral cortex: - occipital lobe maintains a normal appearance with no observable atrophic features - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: triangular inf. frontal gyrus (mild atrophy both left and right), middle frontal gyrus (normal on the left and mild atrophy on the right), medial orbital gyrus (normal on the left and mild atrophy on the right), sup. frontal gyrus medial segment (mild atrophy on the right) and supplementary motor cortex (mild atrophy on the right) - no findings suggestive of atrophy are seen in the temporal lobe - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild atrophy both left and right) and parietal operculum (mild atrophy on the left and normal-to-mild atrophy on the right) - parietal lobe appears within normal limits without apparent atrophy - mild atrophy of the left limbic cortex; normal-to-mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: middle cingulate gyrus (mild atrophy on the left) and anterior cingulate gyrus (mild atrophy on the left) For the ventricles: - no evident size increase noted in the 3rd ventricle - lateral ventricle maintains a typical volume without observable enlargement - no clear enlargement or abnormal growth seen in the 4th ventricle - no evident size increase noted in the external csf - inf. lateral ventricle maintains its expected proportions without signs of enlargement For additional Regions of Interest: - mild atrophy of the left speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) and mild-to-moderate atrophy of the right speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	CN	We have the following subject's personal information: - The subject is a female of 30.0 years old. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 15 animals in 60 seconds. She named 10 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 15. - On the Number Span forward test, her longest span forward was 6. On the Number Span backward test, her longest span backward was 4. - On the Trail Making Test Part A, her total number of seconds to complete is 17, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 71, her number of commission errors is 0, her number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_019_S_4252_MR_MPRAGE_br_raw_20110929160944680_32_S123970_I258947	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the amygdala - mild atrophy of the right accumbens; the left accumbens is normal - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - caudate appears within normal limits without apparent atrophy - mild atrophy of the left putamen; normal-to-mild atrophy of the right putamen - no findings suggestive of atrophy are seen in the thalamus - mild atrophy of the left pallidum; normal-to-mild atrophy of the right pallidum For the cerebral cortex: - temporal lobe appears within normal limits without apparent atrophy - the insular cortex shows no notable changes suggestive of atrophy - no observable atrophic changes in the occipital lobe - no findings suggestive of atrophy are seen in the frontal lobe - no appreciable degenerative or atrophic changes observed in the parietal lobe - limbic cortex appears preserved, with no observable tissue loss For the ventricles: - no observable enlargement of the 3rd ventricle - moderate enlargement of the left lateral ventricle and mild-to-moderate enlargement of the right lateral ventricle - no appreciable enlargement noted in the external csf - severe enlargement of the left inf. lateral ventricle and mild-to-moderate enlargement of the right inf. lateral ventricle - no appreciable enlargement noted in the 4th ventricle For additional Regions of Interest: - no clear atrophic alterations are visible in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	AD	We have the following subject's personal information: - The subject is a female of 86.5 years old. - Subject's current marrietal status is: widowed. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 22. In her MMSE test, she has an orientation to time score of 3. In her MMSE test, she has an orientation to place score of 3.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 5. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 5.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_006_S_0498_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070812122608843_S15857_I67057	On a T1-weighted brain MRI we observed: For the ventricles: - 4th ventricle appears within normal size limits with no apparent enlargement - no clear enlargement or abnormal growth seen in the lateral ventricle - the 3rd ventricle shows no notable changes suggestive of enlargement - mild enlargement of the left inf. lateral ventricle; the right inf. lateral ventricle is normal - external csf appears to be of normal dimensions, with no observable increase in size For the subcortical structures: - amygdala appears preserved, with no observable tissue loss - mild atrophy of the right thalamus; the left thalamus is normal - no evident atrophy or tissue thinning seen in the accumbens - no findings suggestive of atrophy are seen in the caudate - putamen appears within normal limits without apparent atrophy - early/mild-grade volumetric reduction of the left hippocampus - no appreciable degenerative or atrophic changes observed in the pallidum For the cerebral cortex: - parietal lobe appears preserved, with no observable tissue loss - the temporal lobe shows no notable changes suggestive of atrophy - insular cortex appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the occipital lobe - no evident atrophy or tissue thinning seen in the frontal lobe - no clear atrophic alterations are visible in the limbic cortex For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) maintains a normal appearance with no observable atrophic features	CN	We have the following subject's personal information: - The subject is a male of 70.5 years old. - Subject's current marrietal status is: married. - He has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 25. In his MMSE test, he has an orientation to time score of 4. In his MMSE test, he has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 12. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e4,e2 with 1 copy of e4 allele.
ADNI_070_S_6386_MR_Accelerated_Sagittal_MPRAGE__br_raw_20180607115931858_160_S692949_I1006805	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild bilateral atrophy of the caudate - no findings suggestive of atrophy are seen in the putamen - no appreciable degenerative or atrophic changes observed in the accumbens - no observable atrophic changes in the pallidum - no findings suggestive of atrophy are seen in the thalamus - the hippocampus shows no notable changes suggestive of atrophy - amygdala demonstrates a healthy morphology without signs of atrophy For the ventricles: - lateral ventricle appears to be of normal dimensions, with no observable increase in size - 3rd ventricle appears within normal size limits with no apparent enlargement - external csf appears within normal size limits with no apparent enlargement - inf. lateral ventricle maintains its expected proportions without signs of enlargement - 4th ventricle maintains a typical volume without observable enlargement For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the occipital lobe - mild-to-moderate atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex; focal volume loss observed in the following subregions: middle cingulate gyrus (normal on the left and mild atrophy on the right) - no observable atrophic changes in the parietal lobe - temporal lobe appears within normal limits without apparent atrophy - no findings suggestive of atrophy are seen in the frontal lobe - insular cortex maintains a normal appearance with no observable atrophic features For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) demonstrates a healthy morphology without signs of atrophy	CN	We have the following subject's personal information: - The subject is a female of 69.0 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 21 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 29. On the Trail Making Test Part B, her total number of seconds to complete is 69. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_031_S_4042_MR_MPRAGE_br_raw_20130221141013704_141_S182868_I360940	On a T1-weighted brain MRI we observed: For the subcortical structures: - no findings suggestive of atrophy are seen in the amygdala - no clear atrophic alterations are visible in the hippocampus - pallidum appears preserved, with no observable tissue loss - caudate maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the thalamus - mild atrophy of the left putamen; the right putamen is normal - no findings suggestive of atrophy are seen in the accumbens For the cerebral cortex: - no clear atrophic alterations are visible in the parietal lobe - the limbic cortex shows no notable changes suggestive of atrophy - mild-to-moderate atrophy of the left insular cortex; normal-to-mild atrophy of the right insular cortex; focal volume loss observed in the following subregions: frontal operculum (normal-to-mild atrophy on the left and mild atrophy on the right), parietal operculum (mild-to-moderate atrophy on the left and normal on the right) and anterior insula (mild atrophy on the left and normal on the right) - mild-to-moderate atrophy of the left temporal lobe and mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: fusiform gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), planum temporale (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right), temporal pole (mild atrophy both left and right), sup. temporal gyrus (mild atrophy on the left and normal on the right) and inf. temporal gyrus (normal on the left and mild atrophy on the right) - frontal lobe appears within normal limits without apparent atrophy - occipital lobe appears preserved, with no observable tissue loss For the ventricles: - no appreciable enlargement noted in the lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - no appreciable enlargement noted in the inf. lateral ventricle - no evident size increase noted in the 4th ventricle - no findings suggestive of enlargement are seen in the external csf For additional Regions of Interest: - no findings suggestive of atrophy are seen in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	AD	We have the following subject's personal information: - The subject is a male of 59.0 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 26. In his MMSE test, he has an orientation to time score of 4. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - The subject has a Boston Naming Test (BNT) total score of 26. - On the semantic categorical fluency test, the subject named 17 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 4. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 35. On the Trail Making Test Part B, his total number of seconds to complete is 71. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 3.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203490360_03069_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10450224	On a T1-weighted brain MRI we observed: For the subcortical structures: - thalamus maintains a normal appearance with no observable atrophic features - hippocampus appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the amygdala - the caudate shows no notable changes suggestive of atrophy - mild atrophy of the right accumbens; the left accumbens is normal - pallidum maintains a normal appearance with no observable atrophic features - mild atrophy of the right putamen; the left putamen is normal For the ventricles: - no findings suggestive of enlargement are seen in the 4th ventricle - no evident size increase noted in the external csf - lateral ventricle appears within normal size limits with no apparent enlargement - inf. lateral ventricle maintains its expected proportions without signs of enlargement - no observable enlargement of the 3rd ventricle For the cerebral cortex: - no findings suggestive of atrophy are seen in the occipital lobe - temporal lobe appears preserved, with no observable tissue loss - frontal lobe appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the parietal lobe - no evident atrophy or tissue thinning seen in the insular cortex - no observable atrophic changes in the limbic cortex For additional Regions of Interest: - no appreciable degenerative or atrophic changes observed in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	CN	We have the following subject's personal information: - The subject is a female of 30.0 years old. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 30 animals in 60 seconds. She named 11 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 30. - On the Number Span forward test, her longest span forward was 8. On the Number Span backward test, her longest span backward was 2. - On the Trail Making Test Part A, her total number of seconds to complete is 45, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 63, her number of commission errors is 0, her number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in depression or dysphoria, anxiety. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_027_S_5288_MR_Accelerated_Sag_IR-FSPGR_br_raw_20130918141640842_23_S201426_I390934	On a T1-weighted brain MRI we observed: For the cerebral cortex: - limbic cortex appears within normal limits without apparent atrophy - insular cortex appears within normal limits without apparent atrophy - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: sup. occipital gyrus (normal-to-mild atrophy on the left and moderate atrophy on the right), calcarine cortex (mild atrophy both left and right), lingual gyrus (normal on the left and mild atrophy on the right) and inf. occipital gyrus (mild atrophy on the left) - temporal lobe appears within normal limits without apparent atrophy - frontal lobe maintains a normal appearance with no observable atrophic features - parietal lobe appears preserved, with no observable tissue loss For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - the 3rd ventricle shows no notable changes suggestive of enlargement - mild enlargement of the left lateral ventricle; normal-to-mild enlargement of the right lateral ventricle - no observable enlargement of the external csf - mild enlargement of the 4th ventricle For the subcortical structures: - the caudate shows no notable changes suggestive of atrophy - amygdala appears within normal limits without apparent atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - the putamen shows no notable changes suggestive of atrophy - accumbens appears preserved, with no observable tissue loss - pallidum appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the thalamus For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) demonstrates a healthy morphology without signs of atrophy	CN	We have the following subject's personal information: - The subject is a female of 81.9 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 28. - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 33. On the Trail Making Test Part B, her total number of seconds to complete is 85. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203192379_02979_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178310	On a T1-weighted brain MRI we observed: For the subcortical structures: - thalamus appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the pallidum - no evident atrophy or tissue thinning seen in the hippocampus - mild atrophy of the left caudate; normal-to-mild atrophy of the right caudate - no appreciable degenerative or atrophic changes observed in the amygdala - no evident atrophy or tissue thinning seen in the putamen - mild atrophy of the right accumbens; normal-to-mild atrophy of the left accumbens For the ventricles: - inf. lateral ventricle appears within normal size limits with no apparent enlargement - no findings suggestive of enlargement are seen in the lateral ventricle - no appreciable enlargement noted in the external csf - the 3rd ventricle shows no notable changes suggestive of enlargement - mild enlargement of the 4th ventricle For the cerebral cortex: - no findings suggestive of atrophy are seen in the temporal lobe - no findings suggestive of atrophy are seen in the occipital lobe - frontal lobe maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the parietal lobe - mild atrophy of the right limbic cortex; the left limbic cortex is normal; focal volume loss observed in the following subregions: anterior cingulate gyrus (normal on the left and mild atrophy on the right) and middle cingulate gyrus (mild atrophy on the right) - no clear atrophic alterations are visible in the insular cortex For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) maintains a normal appearance with no observable atrophic features	BV	We have the following subject's personal information: - The subject is a female of 67.0 years old. - She has 15.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 20 animals in 60 seconds. She named 11 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 18. - On the Number Span forward test, her longest span forward was 5. On the Number Span backward test, her longest span backward was 5. - On the Trail Making Test Part A, her total number of seconds to complete is 40, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 105, her number of commission errors is 3, her number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in apathy or indifference, disinhibition, nighttime behaviors, appetite and eating, a mild (noticeable, but not significant) change in agitation or aggression, depression or dysphoria, anxiety, irritability or lability. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 3.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_027_S_10430_MR_Accelerated_Sagittal_MPRAGE_MSV22_br_raw_20250120192736055_1_I11097431	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no observable atrophic changes in the parietal lobe - mild atrophy of the right limbic cortex; the left limbic cortex is normal; focal volume loss observed in the following subregions: parahippocampal gyrus (mild-to-moderate atrophy on the left and normal on the right) and anterior cingulate gyrus (mild atrophy on the right) - no clear atrophic alterations are visible in the frontal lobe - no clear atrophic alterations are visible in the insular cortex - occipital lobe appears preserved, with no observable tissue loss - mild bilateral atrophy of the temporal lobe; focal volume loss observed in the following subregions: middle temporal gyrus (mild atrophy both left and right), temporal pole (mild atrophy both left and right) and planum polare (mild atrophy on the right) For the subcortical structures: - mild bilateral atrophy of the caudate - pallidum appears within normal limits without apparent atrophy - early/mild-grade volumetric reduction of the left hippocampus - mild atrophy of the right thalamus; normal-to-mild atrophy of the left thalamus - no findings suggestive of atrophy are seen in the amygdala - accumbens appears preserved, with no observable tissue loss - mild bilateral atrophy of the putamen For the ventricles: - mild-to-moderate enlargement of the left inf. lateral ventricle; normal-to-mild enlargement of the right inf. lateral ventricle - no appreciable enlargement noted in the 3rd ventricle - 4th ventricle maintains a typical volume without observable enlargement - the external csf shows no notable changes suggestive of enlargement - no clear enlargement or abnormal growth seen in the lateral ventricle For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears within normal limits without apparent atrophy	CN	We have the following subject's personal information: - The subject is a female of 56.5 years old. - Subject's current marrietal status is: married. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following subject's family history information: - Both of her parents are reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 14. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
FTLD_203380795_03598_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10450964	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the caudate - no appreciable degenerative or atrophic changes observed in the hippocampus - no evident atrophy or tissue thinning seen in the thalamus - no observable atrophic changes in the amygdala - the pallidum shows no notable changes suggestive of atrophy - no findings suggestive of atrophy are seen in the accumbens - no observable atrophic changes in the putamen For the cerebral cortex: - mild bilateral atrophy of the limbic cortex; focal volume loss observed in the following subregions: parahippocampal gyrus (mild atrophy both left and right) - insular cortex demonstrates a healthy morphology without signs of atrophy - parietal lobe demonstrates a healthy morphology without signs of atrophy - mild atrophy of the left temporal lobe; the right temporal lobe is normal; focal volume loss observed in the following subregions: middle temporal gyrus (mild atrophy on the left and normal on the right) and fusiform gyrus (mild atrophy on the left and normal on the right) - no evident atrophy or tissue thinning seen in the frontal lobe - the occipital lobe shows no notable changes suggestive of atrophy For the ventricles: - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - external csf appears within normal size limits with no apparent enlargement - the lateral ventricle shows no notable changes suggestive of enlargement For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears within normal limits without apparent atrophy	BV	We have the following subject's personal information: - The subject is a male of 68.0 years old. - He has 20.0 years of education (equivalent to doctorate) - The subject is left-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 23 animals in 60 seconds. He named 16 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 26. - On the Number Span forward test, his longest span forward was 9. On the Number Span backward test, his longest span backward was 8. - On the Trail Making Test Part A, his total number of seconds to complete is 23, his number of commission errors is 1, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 59, his number of commission errors is 1, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in depression or dysphoria, a mild (noticeable, but not significant) change in disinhibition. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_021_S_0424_MR_MPR__GradWarp__N3__Scaled_Br_20101111161351528_S84608_I204863	On a T1-weighted brain MRI we observed: For the subcortical structures: - caudate appears preserved, with no observable tissue loss - no observable atrophic changes in the putamen - thalamus appears within normal limits without apparent atrophy - pallidum demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the accumbens - the hippocampus shows no notable changes suggestive of atrophy - no findings suggestive of atrophy are seen in the amygdala For the ventricles: - no clear enlargement or abnormal growth seen in the 4th ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - external csf appears to be of normal dimensions, with no observable increase in size - mild-to-moderate bilateral enlargement of the lateral ventricle - moderate bilateral enlargement of the inf. lateral ventricle For the cerebral cortex: - no findings suggestive of atrophy are seen in the occipital lobe - mild bilateral atrophy of the parietal lobe; focal volume loss observed in the following subregions: sup. parietal lobule (mild atrophy both left and right), postcentral gyrus (normal on the left and mild-to-moderate atrophy on the right) and supramarginal gyrus (mild atrophy on the left) - no appreciable degenerative or atrophic changes observed in the insular cortex - frontal lobe appears within normal limits without apparent atrophy - temporal lobe maintains a normal appearance with no observable atrophic features - no observable atrophic changes in the limbic cortex For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) appears within normal limits without apparent atrophy	AD	We have the following subject's personal information: - The subject is a male of 84.7 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 23. In his MMSE test, he has an orientation to time score of 3. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - The subject has a Boston Naming Test (BNT) total score of 29. - On the semantic categorical fluency test, the subject named 19 animals in 60 seconds. He named 10 vegetables in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 6. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for heating water, making a cup of coffee, turning off the stove. The subject has difficulity, but does by himself, for preparing a balanced meal. The subject requires assitance for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for remembering appointments, family occasions, holidays, medications. - On the Digit Span test of the Wechsler Memory Scale-Revised, his digit span forward length is 6, his digit span forward trials correct is 8, his digit span backward length is 3., his digit span forward trials correct is 3. - On the Trail Making Test Part A, his total number of seconds to complete is 100. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in anxiety, elation or euphoria, motor disturbance, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 4.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0106_MR_T1_mprage_S3_DIS3D_br_raw_20170815140458478_142_S595499_I888146	On a T1-weighted brain MRI we observed: For the subcortical structures: - amygdala maintains a normal appearance with no observable atrophic features - thalamus appears within normal limits without apparent atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - no evident atrophy or tissue thinning seen in the putamen - pallidum appears preserved, with no observable tissue loss - the accumbens shows no notable changes suggestive of atrophy - no findings suggestive of atrophy are seen in the caudate For the cerebral cortex: - no findings suggestive of atrophy are seen in the limbic cortex - mild-to-moderate atrophy of the left insular cortex and mild atrophy of the right insular cortex; focal volume loss observed in the following subregions: central operculum (mild-to-moderate atrophy on the left and mild atrophy on the right) and posterior insula (mild atrophy on the left and normal on the right) - moderate atrophy of the left frontal lobe and mild atrophy of the right frontal lobe; focal volume loss observed in the following subregions: frontal pole (mild atrophy both left and right), middle frontal gyrus (mild atrophy both left and right), lateral orbital gyrus (mild-to-moderate atrophy on the left and normal on the right), gyrus rectus (mild atrophy on the left and normal on the right), triangular inf. frontal gyrus (mild atrophy on the left and normal on the right), medial frontal cortex (mild atrophy on the left and normal on the right), posterior orbital gyrus (normal on the left and mild atrophy on the right), precentral gyrus (mild atrophy on the left and normal on the right) and sup. frontal gyrus medial segment (mild atrophy on the left and normal on the right) - mild atrophy of the left parietal lobe; the right parietal lobe is normal; focal volume loss observed in the following subregions: sup. parietal lobule (mild atrophy both left and right) - temporal lobe appears preserved, with no observable tissue loss - occipital lobe appears within normal limits without apparent atrophy For the ventricles: - mild-to-moderate enlargement of the 3rd ventricle - severe enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - no findings suggestive of enlargement are seen in the external csf - moderate bilateral enlargement of the lateral ventricle - 4th ventricle maintains a typical volume without observable enlargement For additional Regions of Interest: - mild atrophy of the left speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex); the right speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) is normal	PNFA	We have the following subject's personal information: - The subject is a female of 78.0 years old. - She has 14.0 years of education We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 23. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for remembering appointments, family occasions, holidays, medications. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for shopping alone for clothes, household necessities, or groceries, for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in agitation or aggression, anxiety, irritability or lability, motor disturbance, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. Her standard CDR Sum of Boxes score is 3.0. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 0.5 (questionnable impairment). Description: Questionable changes in comportment, empathy, appropriateness of actions. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
FTLD_203232136_02633_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10177738	On a T1-weighted brain MRI we observed: For the cerebral cortex: - frontal lobe maintains a normal appearance with no observable atrophic features - no appreciable degenerative or atrophic changes observed in the parietal lobe - no observable atrophic changes in the occipital lobe - moderate bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: anterior insula (severe atrophy on the left and mild-to-moderate atrophy on the right), posterior insula (mild-to-moderate atrophy on the left and mild atrophy on the right), central operculum (mild-to-moderate atrophy on the left and normal on the right) and frontal operculum (normal on the left and mild-to-moderate atrophy on the right) - moderate atrophy of the left limbic cortex and mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: entorhinal area (moderate atrophy on the left and mild-to-moderate atrophy on the right), parahippocampal gyrus (moderate atrophy on the left and mild-to-moderate atrophy on the right), anterior cingulate gyrus (mild-to-moderate atrophy on the left and normal on the right) and posterior cingulate gyrus (mild atrophy on the left and normal on the right) - severe atrophy of the left temporal lobe and moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: fusiform gyrus (moderate atrophy both left and right), temporal pole (moderate atrophy both left and right), inf. temporal gyrus (moderate atrophy on the left and mild atrophy on the right), sup. temporal gyrus (mild atrophy on the left and normal on the right) and middle temporal gyrus (mild atrophy on the left) For the ventricles: - mild-to-moderate enlargement of the external csf - 4th ventricle maintains its expected proportions without signs of enlargement - severe bilateral enlargement of the inf. lateral ventricle - lateral ventricle appears within normal size limits with no apparent enlargement - 3rd ventricle maintains a typical volume without observable enlargement For the subcortical structures: - the pallidum shows no notable changes suggestive of atrophy - no observable atrophic changes in the caudate - thalamus demonstrates a healthy morphology without signs of atrophy - severe bilateral atrophy of the amygdala - severe atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - mild-to-moderate atrophy of the left accumbens; normal-to-mild atrophy of the right accumbens - mild-to-moderate atrophy of the left putamen; the right putamen is normal For additional Regions of Interest: - no clear atrophic alterations are visible in the speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex)	BV	We have the following subject's personal information: - The subject is a male of 56.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 1. - On the semantic categorical fluency test, the subject named 3 animals in 60 seconds. He named 0 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 0. - On the Number Span forward test, his longest span forward was 4. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 44, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 162, his number of commission errors is 1, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in depression or dysphoria, disinhibition, motor disturbance, a moderate (significant, but not dramatic) change in agitation or aggression, anxiety, elation or euphoria, irritability or lability, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 6.0. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
ADNI_021_S_6918_MR_Accelerated_Sag_IR-FSPGR_br_raw_20210322141028136_3_S1008709_I1423357	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no observable atrophic changes in the insular cortex - no clear atrophic alterations are visible in the limbic cortex - no observable atrophic changes in the parietal lobe - no appreciable degenerative or atrophic changes observed in the frontal lobe - no evident atrophy or tissue thinning seen in the occipital lobe - the temporal lobe shows no notable changes suggestive of atrophy For the subcortical structures: - no evident atrophy or tissue thinning seen in the putamen - amygdala demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the accumbens - pallidum appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the hippocampus - mild bilateral atrophy of the thalamus - no evident atrophy or tissue thinning seen in the caudate For the ventricles: - mild-to-moderate enlargement of the 3rd ventricle - the 4th ventricle shows no notable changes suggestive of enlargement - no findings suggestive of enlargement are seen in the lateral ventricle - no findings suggestive of enlargement are seen in the inf. lateral ventricle - external csf maintains its expected proportions without signs of enlargement For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) demonstrates a healthy morphology without signs of atrophy	CN	We have the following subject's personal information: - The subject is a male of 57.4 years old. - Subject's current marrietal status is: never married. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 15. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203836920_02023_MR_Sagittal_MP-Rage_br_raw_20230206183939680_I10182606	On a T1-weighted brain MRI we observed: For the subcortical structures: - no observable atrophic changes in the accumbens - no clear atrophic alterations are visible in the caudate - no findings suggestive of atrophy are seen in the pallidum - thalamus appears preserved, with no observable tissue loss - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus - no findings suggestive of atrophy are seen in the amygdala - no observable atrophic changes in the putamen For the ventricles: - no findings suggestive of enlargement are seen in the inf. lateral ventricle - no appreciable enlargement noted in the 3rd ventricle - 4th ventricle maintains its expected proportions without signs of enlargement - external csf appears to be of normal dimensions, with no observable increase in size - mild enlargement of the right lateral ventricle; normal-to-mild enlargement of the left lateral ventricle For the cerebral cortex: - frontal lobe appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the occipital lobe - insular cortex appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the limbic cortex - the parietal lobe shows no notable changes suggestive of atrophy - temporal lobe appears within normal limits without apparent atrophy For additional Regions of Interest: - speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) maintains a normal appearance with no observable atrophic features	CN	We have the following subject's personal information: - The subject is a female of 29.0 years old. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 29. - On the semantic categorical fluency test, the subject named 22 animals in 60 seconds. She named 14 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 25. - On the Number Span forward test, her longest span forward was 5. On the Number Span backward test, her longest span backward was 5. - On the Trail Making Test Part A, her total number of seconds to complete is 22, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 45, her number of commission errors is 0, her number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_003_S_4373_MR_Accelerated_SAG_IR-SPGR__br_raw_20111227095734176_117_S134978_I274607	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the left lateral ventricle and moderate enlargement of the right lateral ventricle - severe enlargement of the external csf - mild enlargement of the 3rd ventricle - no findings suggestive of enlargement are seen in the 4th ventricle - severe bilateral enlargement of the inf. lateral ventricle For the subcortical structures: - moderate bilateral atrophy of the amygdala - moderate bilateral atrophy of the accumbens - thalamus appears preserved, with no observable tissue loss - mild atrophy of the left pallidum; the right pallidum is normal - early/mild-grade volumetric reduction of the left hippocampus, early/mild-grade volumetric reduction of the right hippocampus - mild-to-moderate bilateral atrophy of the caudate - moderate atrophy of the left putamen and mild atrophy of the right putamen For the cerebral cortex: - the occipital lobe shows no notable changes suggestive of atrophy - moderate atrophy of the left parietal lobe and mild-to-moderate atrophy of the right parietal lobe; focal volume loss observed in the following subregions: precuneus (moderate atrophy both left and right), angular gyrus (mild atrophy both left and right), sup. parietal lobule (mild atrophy on the left and normal on the right), supramarginal gyrus (normal on the left and mild atrophy on the right) and postcentral gyrus (mild atrophy on the left) - moderate atrophy of the left limbic cortex and mild-to-moderate atrophy of the right limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (moderate atrophy on the left and mild-to-moderate atrophy on the right), posterior cingulate gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), middle cingulate gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) and parahippocampal gyrus (mild atrophy on the left) - moderate atrophy of the left frontal lobe and mild atrophy of the right frontal lobe; focal volume loss observed in the following subregions: medial frontal cortex (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right), middle frontal gyrus (mild atrophy both left and right), supplementary motor cortex (mild atrophy on the left and normal-to-mild atrophy on the right), gyrus rectus (mild atrophy on the left and normal on the right), medial orbital gyrus (normal on the left and mild atrophy on the right), precentral gyrus medial segment (mild atrophy on the left and normal on the right), sup. frontal gyrus medial segment (normal on the left and mild atrophy on the right), sup. frontal gyrus (mild atrophy on the left and normal on the right) and precentral gyrus (mild atrophy on the left) - moderate atrophy of the left insular cortex and mild-to-moderate atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (moderate atrophy on the left and mild atrophy on the right), posterior insula (mild-to-moderate atrophy on the left and mild atrophy on the right), central operculum (mild-to-moderate atrophy on the left and mild atrophy on the right), parietal operculum (mild atrophy on the left and normal on the right) and frontal operculum (mild atrophy on the right) - moderate atrophy of the left temporal lobe and mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: middle temporal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), inf. temporal gyrus (mild-to-moderate atrophy on the left and normal on the right), fusiform gyrus (mild atrophy on the left and normal on the right) and temporal pole (mild atrophy on the left and normal on the right) For additional Regions of Interest: - mild atrophy of the left speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex); the right speech motor network (broca's area + frontal operculum + precentral gyrus + supplementary motor cortex) is normal	AD	We have the following subject's personal information: - The subject is a female of 71.2 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 11. - On the semantic categorical fluency test, the subject named 3 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has difficulity, but does by himself, for heating water, making a cup of coffee, turning off the stove, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for keeping track of current events, for remembering appointments, family occasions, holidays, medications. The subject is dependent for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for preparing a balanced meal, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 150. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.

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