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In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A patient who developed paraplegia f... | A patient who developed paraplegia following the intrathecal instillation of <span class="chemical">methotrexate</span> is discribed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The ten previously reported cases of... | The ten previously reported cases of this unusual complication are reviewed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The following factors appear to pred... | The following factors appear to predispose to the development of this complication : abnormal cerebrospinal dynamics related to the presence of central nervous system leukemia , and epidural cerebrospinal leakage ; elevated cerebrospinal fluid <span class="chemical">methothexate</span> concentration related to abnormal... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The role of methotrexate contaminant... | The role of <span class="chemical">methotrexate</span> contaminants , local folate deficiency , and cranial irradiation in the pathogenesis of intrathecal <span class="chemical">methotrexate</span> toxicity is unclear . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The incidence of neurotoxicity may b... | The incidence of neurotoxicity may be reduced by employing lower doses of <span class="chemical">methotrexate</span> in the presence of central nervous system leukemia , in older children and adults , and in the presence of epidural leakage . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Only preservative - free methotrexat... | Only preservative - free <span class="chemical">methotrexate</span> in Elliott ' s B Solution at a concentration of not more than 1 mg / ml should be used for intrathecal administration . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Periodic monitoring of cerebruspinal... | Periodic monitoring of cerebruspinal fluid <span class="chemical">methotrexate</span> levels may be predictive of the development of serious neurotoxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Hyperosmolar nonketotic coma precipi... | Hyperosmolar nonketotic coma precipitated by <span class="chemical">lithium</span> - induced nephrogenic diabetes insipidus . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A 45 - year - old man , with a 10 - ... | A 45 - year - old man , with a 10 - year history of manic depression treated with <span class="chemical">lithium</span> , was admitted with hyperosmolar , nonketotic coma . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: He gave a five - year history of pol... | He gave a five - year history of polyuria and polydipsia , during which time urinalysis had been negative for <span class="chemical">glucose</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After recovery from hyperglycaemia ,... | After recovery from hyperglycaemia , he remained polyuric despite normal blood <span class="chemical">glucose</span> concentrations ; water deprivation testing indicated nephrogenic diabetes insipidus , likely to be <span class="chemical">lithium</span> - induced . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We hypothesize that when this man de... | We hypothesize that when this man developed type 2 diabetes , chronic polyuria due to nephrogenic diabetes insipidus was sufficient to precipitate hyperosmolar dehydration . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Effects of the intracoronary infusio... | Effects of the intracoronary infusion of <span class="chemical">cocaine</span> on left ventricular systolic and diastolic function in humans . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: BACKGROUND : In dogs , a large amoun... | BACKGROUND : In dogs , a large amount of intravenous <span class="chemical">cocaine</span> causes a profound deterioration of left ventricular ( LV ) systolic function and an increase in LV end - diastolic pressure . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This study was done to assess the in... | This study was done to assess the influence of a high intracoronary <span class="chemical">cocaine</span> concentration on LV systolic and diastolic function in humans . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: METHODS AND RESULTS : In 20 patients... | METHODS AND RESULTS : In 20 patients ( 14 men and 6 women aged 39 to 72 years ) referred for cardiac catheterization for the evaluation of chest pain , we measured heart rate , systemic arterial pressure , LV pressure and its first derivative ( dP / dt ) , and LV volumes and ejection fraction before and during the fina... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: No variable changed with saline .
##... | No variable changed with saline . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: With cocaine , the drug concentratio... | With <span class="chemical">cocaine</span> , the drug concentration in blood obtained from the coronary sinus was 3 . 0 + / - 0 . 4 ( mean + / - SD ) mg / L , similar in magnitude to the blood <span class="chemical">cocaine</span> concentration reported in abusers dying of <span class="chemical">cocaine</span> intoxica... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Cocaine induced no significant chang... | <span class="chemical">Cocaine</span> induced no significant change in heart rate , LV dP / dt ( positive or negative ) , or LV end - diastolic volume , but it caused an increase in systolic and mean arterial pressures , LV end - diastolic pressure , and LV end - systolic volume , as well as a decrease in LV ejection f... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSIONS : In humans , the intrac... | CONCLUSIONS : In humans , the intracoronary infusion of <span class="chemical">cocaine</span> sufficient in amount to achieve a high drug concentration in coronary sinus blood causes a deterioration of LV systolic and diastolic performance . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Ascending dose tolerance study of in... | Ascending dose tolerance study of intramuscular <span class="chemical">carbetocin</span> administered after normal vaginal birth . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: OBJECTIVE : To determine the maximum... | OBJECTIVE : To determine the maximum tolerated dose ( MTD ) of <span class="chemical">carbetocin</span> ( a long - acting synthetic analogue of <span class="chemical">oxytocin</span> ) , when administered immediately after vaginal delivery at term . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: MATERIALS AND METHODS : Carbetocin w... | MATERIALS AND METHODS : <span class="chemical">Carbetocin</span> was given as an intramuscular injection immediately after the birth of the infant in 45 healthy women with normal singleton pregnancies who delivered vaginally at term . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Dosage groups of 15 , 30 , 50 , 75 ,... | Dosage groups of 15 , 30 , 50 , 75 , 100 , 125 , 150 , 175 or 200 microg <span class="chemical">carbetocin</span> were assigned to blocks of three women according to the continual reassessment method ( CRM ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: RESULTS : All dosage groups consiste... | RESULTS : All dosage groups consisted of three women , except those with 100 microg ( n = 6 ) and 200 microg ( n = 18 ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Recorded were dose - limiting advers... | Recorded were dose - limiting adverse events : hyper - or hypotension ( three ) , severe abdominal pain ( 0 ) , vomiting ( 0 ) and retained placenta ( four ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Serious adverse events occurred in s... | Serious adverse events occurred in seven women : six cases with blood loss > or = 1000 ml , four cases of manual placenta removal , five cases of additional oxytocics administration and five cases of blood transfusion . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Maximum blood loss was greatest at t... | Maximum blood loss was greatest at the upper and lower dose levels , and lowest in the 70 - 125 microg dose range . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Four out of six cases with blood los... | Four out of six cases with blood loss > or = 1000 ml occurred in the 200 microg group . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: The majority of additional administr... | The majority of additional administration of oxytocics ( 4 / 5 ) and blood transfusion ( 3 / 5 ) occurred in the dose groups of 200 microg . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: All retained placentae were found in... | All retained placentae were found in the group of 200 microg . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSION : The MTD was calculated ... | CONCLUSION : The MTD was calculated to be at 200 microg <span class="chemical">carbetocin</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Heparin - induced thrombocytopenia ,... | <span class="chemical">Heparin</span> - induced thrombocytopenia , paradoxical thromboembolism , and other side effects of <span class="chemical">heparin</span> therapy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Although several new anticoagulant d... | Although several new anticoagulant drugs are in development , <span class="chemical">heparin</span> remains the drug of choice for most anticoagulation needs . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The clinical effects of heparin are ... | The clinical effects of <span class="chemical">heparin</span> are meritorious , but side effects do exist . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Important untoward effects of hepari... | Important untoward effects of <span class="chemical">heparin</span> therapy including <span class="chemical">heparin</span> - induced thrombocytopenia , <span class="chemical">heparin</span> - associated osteoporosis , eosinophilia , skin reactions , allergic reactions other than thrombocytopenia and alopecia will be d... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Nonopaque crystal deposition causing... | Nonopaque crystal deposition causing ureteric obstruction in patients with HIV undergoing <span class="chemical">indinavir</span> therapy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: OBJECTIVE : We describe the unique C... | OBJECTIVE : We describe the unique CT features of ureteric calculi in six HIV - infected patients receiving <span class="chemical">indinavir</span> , the most commonly used HIV protease inhibitor , which is associated with an increased incidence of urolithiasis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSION : Ureteric obstruction ca... | CONCLUSION : Ureteric obstruction caused by precipitated <span class="chemical">indinavir</span> crystals may be difficult to diagnose with unenhanced CT . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The calculi are not opaque , and sec... | The calculi are not opaque , and secondary signs of obstruction may be absent or minimal and should be sought carefully . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Images may need to be obtained using... | Images may need to be obtained using i . v . contrast material to enable diagnosis of ureteric stones or obstruction in patients with HIV infection who receive <span class="chemical">indinavir</span> therapy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Ischemic colitis and sumatriptan use... | Ischemic colitis and <span class="chemical">sumatriptan</span> use . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Sumatriptan succinate , a serotonin ... | <span class="chemical">Sumatriptan succinate</span> , a <span class="chemical">serotonin</span> - 1 ( <span class="chemical">5 - hydroxytryptamine</span> - 1 ) receptor agonist , is an antimigraine drug that is reported to act by selectively constricting intracranial arteries . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Recently , vasopressor responses tha... | Recently , vasopressor responses that are distinct from the cranial circulation have been demonstrated to occur in the systemic , pulmonary , and coronary circulations . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Cases have been published of coronar... | Cases have been published of coronary vasospasm , myocardial ischemia , and myocardial infarction occurring after <span class="chemical">sumatriptan</span> use . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We report on the development of 8 se... | We report on the development of 8 serious cases of ischemic colitis in patients with migraine treated with <span class="chemical">sumatriptan</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Pallidotomy with the gamma knife : a... | Pallidotomy with the gamma knife : a positive experience . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: 51 patients with medically refractor... | 51 patients with medically refractory Parkinson ' s disease underwent stereotactic posteromedial pallidotomy between August 1993 and February 1997 for treatment of bradykinesia , rigidity , and <span class="chemical">L - DOPA</span> - induced dyskinesias . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In 29 patients , the pallidotomies w... | In 29 patients , the pallidotomies were performed with the Leksell Gamma Knife and in 22 they were performed with the standard radiofrequency ( RF ) method . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Clinical assessment as well as blind... | Clinical assessment as well as blinded ratings of Unified Parkinson ' s Disease Rating Scale ( UPDRS ) scores were carried out pre - and postoperatively . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Mean follow - up time is 20 . 6 mont... | Mean follow - up time is 20 . 6 months ( range 6 - 48 ) and all except 4 patients have been followed more than one year . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: 85 percent of patients with dyskines... | 85 percent of patients with dyskinesias were relieved of symptoms , regardless of whether the pallidotomies were performed with the Gamma Knife or radiofrequency methods . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: About 2 / 3 of the patients in both ... | About 2 / 3 of the patients in both Gamma Knife and radiofrequency groups showed improvements in bradykinesia and rigidity , although when considered as a group neither the Gamma Knife nor the radiofrequency group showed statistically significant improvements in UPDRS scores . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: One patient in the Gamma Knife group... | One patient in the Gamma Knife group ( 3 . 4 % ) developed a homonymous hemianopsia 9 months following treatment and 5 patients ( 27 . 7 % ) in the radiofrequency group became transiently confused postoperatively . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: No other complications were seen .
#... | No other complications were seen . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Gamma Knife pallidotomy is as effect... | Gamma Knife pallidotomy is as effective as radiofrequency pallidotomy in controlling certain of the symptoms of Parkinson ' s disease . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: It may be the only practical techniq... | It may be the only practical technique available in certain patients , such as those who take anticoagulants , have bleeding diatheses or serious systemic medical illnesses . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: It is a viable option for other pati... | It is a viable option for other patients as well . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Centrally mediated cardiovascular ef... | Centrally mediated cardiovascular effects of intracisternal application of <span class="chemical">carbachol</span> in anesthetized rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: The pressor response to the intracis... | The pressor response to the intracisternal ( i . c . ) injection of <span class="chemical">carbachol</span> ( 1 mug ) in anesthetized rats was analyzed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: This response was significantly redu... | This response was significantly reduced by the intravenous ( i . v . ) injection of <span class="chemical">guanethidine</span> ( 5 mg ) , <span class="chemical">hexamethonium</span> ( 10 mg ) or <span class="chemical">phentolamine</span> ( 5 mg ) , and conversely , potentiated by i . v . <span class="chemical">desmethy... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: On the other hand , the pressor resp... | On the other hand , the pressor response to i . c . <span class="chemical">carbachol</span> ( 1 mug ) was almost completely blocked by i . c . <span class="chemical">atropine</span> ( 3 mug ) or <span class="chemical">hexamethonium</span> ( 500 mug ) , and significantly reduced by i . c . <span class="chemical">chlorpr... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: The pressor response to i . c . carb... | The pressor response to i . c . <span class="chemical">carbachol</span> ( 1 mug ) remained unchanged after sectioning of the bilateral cervical vagal nerves but disappeared after sectioning of the spinal cord ( C7 - C8 ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: From the above result it is suggeste... | From the above result it is suggested that the pressor response to i . c . <span class="chemical">carbachol</span> ortral and peripheral adrenergic mechanisms , and that the sympathetic trunk is the main pathway . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Neuroleptic malignant syndrome and m... | Neuroleptic malignant syndrome and <span class="chemical">methylphenidate</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: A 1 - year - old female presented wi... | A 1 - year - old female presented with neuroleptic malignant syndrome probably caused by <span class="chemical">methylphenidate</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: She had defects in the supratentoria... | She had defects in the supratentorial brain including the basal ganglia and the striatum ( multicystic encephalomalacia ) due to severe perinatal hypoxic - ischemic encephalopathy , which was considered to be a possible predisposing factor causing neuroleptic malignant syndrome . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: A dopaminergic blockade mechanism ge... | A dopaminergic blockade mechanism generally is accepted as the pathogenesis of this syndrome . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: However , methylphenidate is a dopam... | However , <span class="chemical">methylphenidate</span> is a <span class="chemical">dopamine</span> agonist via the inhibition of uptake of <span class="chemical">dopamine</span> , and therefore dopaminergic systems in the brainstem ( mainly the midbrain ) and the spinal cord were unlikely to participate in the onset o... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: A relative gamma - aminobutyric acid... | A relative <span class="chemical">gamma - aminobutyric acid</span> - ergic deficiency might occur because <span class="chemical">diazepam</span> , a <span class="chemical">gamma - aminobutyric acid</span> - mimetic agent , was strikingly effective . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This is the first reported patient w... | This is the first reported patient with neuroleptic malignant syndrome probably caused by <span class="chemical">methylphenidate</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Differential effects of 17alpha - et... | Differential effects of <span class="chemical">17alpha - ethinylestradiol</span> on the neutral and acidic pathways of <span class="chemical">bile salt</span> synthesis in the rat . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Effects of 17alpha - ethinylestradio... | Effects of <span class="chemical">17alpha - ethinylestradiol</span> ( <span class="chemical">EE</span> ) on the neutral and acidic biosynthetic pathways of <span class="chemical">bile salt</span> ( <span class="chemical">BS</span> ) synthesis were evaluated in rats with an intact enterohepatic circulation and in rats w... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: For this purpose , bile salt pool co... | For this purpose , <span class="chemical">bile salt</span> pool composition , synthesis of individual <span class="chemical">BS</span> in vivo , hepatic activities , and expression levels of <span class="chemical">cholesterol</span> 7alpha - hydroxylase ( CYP7A ) , and <span class="chemical">sterol</span> 27 - hydroxyl... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: BS pool size was decreased by 27 % b... | <span class="chemical">BS</span> pool size was decreased by 27 % but total <span class="chemical">BS</span> synthesis was not affected by <span class="chemical">EE</span> in intact rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Synthesis of cholate was reduced by ... | Synthesis of <span class="chemical">cholate</span> was reduced by 68 % in <span class="chemical">EE</span> - treated rats , while that of <span class="chemical">chenodeoxycholate</span> was increased by 60 % . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The recently identified Delta22 - is... | The recently identified Delta22 - isomer of beta - muricholate contributed for 5 . 4 % and 18 . 3 % ( P < 0 . 01 ) to the pool in control and <span class="chemical">EE</span> - treated rats , respectively , but could not be detected in bile after exhaustion of the pool . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A clear reduction of BS synthesis wa... | A clear reduction of <span class="chemical">BS</span> synthesis was found in bile - diverted rats treated with <span class="chemical">EE</span> , yet biliary <span class="chemical">BS</span> composition was only minimally affected . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Activity of CYP7A was decreased by E... | Activity of CYP7A was decreased by <span class="chemical">EE</span> in both intact and bile - diverted rats , whereas the activity of the CYP27 was not affected . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Hepatic mRNA levels of CYP7A were si... | Hepatic mRNA levels of CYP7A were significantly reduced by <span class="chemical">EE</span> in bile - diverted rats only ; CYP27 mRNA levels were not affected by <span class="chemical">EE</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In addition , mRNA levels of sterol ... | In addition , mRNA levels of <span class="chemical">sterol</span> 12alpha - hydroxylase and lithocholate 6beta - hydroxylase were increased by bile diversion and suppressed by <span class="chemical">EE</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This study shows that 17alpha - ethi... | This study shows that <span class="chemical">17alpha - ethinylestradiol</span> ( <span class="chemical">EE</span> ) - induced intrahepatic cholestasis in rats is associated with selective inhibition of the neutral pathway of <span class="chemical">bile salt</span> ( <span class="chemical">BS</span> ) synthesis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Simultaneous impairment of other enz... | Simultaneous impairment of other enzymes in the <span class="chemical">BS</span> biosynthetic pathways may contribute to overall effects of <span class="chemical">EE</span> on <span class="chemical">BS</span> synthesis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Glibenclamide - sensitive hypotensio... | <span class="chemical">Glibenclamide</span> - sensitive hypotension produced by <span class="chemical">helodermin</span> assessed in the rat . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The effects of helodermin , a basic ... | The effects of <span class="chemical">helodermin</span> , a basic 35 - <span class="chemical">amino acid</span> peptide isolated from the venom of a lizard salivary gland , on arterial blood pressure and heart rate were examined in the rat , focusing on the possibility that activation of <span class="chemical">ATP</spa... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The results were also compared with ... | The results were also compared with those of vasoactive intestinal polypeptide ( VIP ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Helodermin produced hypotension in a... | <span class="chemical">Helodermin</span> produced hypotension in a dose - dependent manner with approximately similar potency and duration to VIP . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Hypotension induced by both peptides... | Hypotension induced by both peptides was significantly attenuated by <span class="chemical">glibenclamide</span> , which abolished a <span class="chemical">levcromakalim</span> - produced decrease in arterial blood pressure . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Oxyhemoglobin did not affect heloder... | Oxyhemoglobin did not affect <span class="chemical">helodermin</span> - induced hypotension , whereas it shortened the duration of <span class="chemical">acetylcholine</span> ( <span class="chemical">ACh</span> ) - produced hypotension . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These findings suggest that heloderm... | These findings suggest that <span class="chemical">helodermin</span> - produced hypotension is partly attributable to the activation of <span class="chemical">glibenclamide</span> - sensitive <span class="chemical">K</span> + channels ( <span class="chemical">K</span> ( <span class="chemical">ATP</span> ) channels ) , ... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: EDRF ( endothelium - derived relaxin... | EDRF ( endothelium - derived relaxing factor ) / <span class="chemical">nitric oxide</span> does not seem to play an important role in the peptide - produced hypotension . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Long - term efficacy and adverse eve... | Long - term efficacy and adverse event of <span class="chemical">nifedipine</span> sustained - release tablets for <span class="chemical">cyclosporin A</span> - induced hypertension in patients with psoriasis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Thirteen psoriatic patients with hyp... | Thirteen psoriatic patients with hypertension during the course of <span class="chemical">cyclosporin A</span> therapy were treated for 25 months with a <span class="chemical">calcium</span> channel blocker , sustained - release <span class="chemical">nifedipine</span> , to study the clinical antihypertensive effects a... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Seven of the 13 patients had exhibit... | Seven of the 13 patients had exhibited a subclinical hypertensive state before <span class="chemical">cyclosporin A</span> therapy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Both systolic and diastolic blood pr... | Both systolic and diastolic blood pressures of these 13 patients were decreased significantly after 4 weeks of <span class="chemical">nifedipine</span> therapy , and blood pressure was maintained within the normal range thereafter for 25 months . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The adverse events during combined t... | The adverse events during combined therapy with <span class="chemical">cyclosporin A</span> and <span class="chemical">nifedipine</span> included an increase in <span class="chemical">blood urea nitrogen</span> levels in 9 of the 13 patients and development of gingival hyperplasia in 2 of the 13 patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Our findings indicate that sustained... | Our findings indicate that sustained - release <span class="chemical">nifedipine</span> is useful for hypertensive psoriatic patients under long - term treatment with <span class="chemical">cyclosporin A</span> , but that these patients should be monitored for gingival hyperplasia . |
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