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Glyburide - induced hepatitis. Drug - induced hepatotoxicity, although common, has been reported only infrequently with sulfonylureas. For glyburide, a second - generation sulfonylurea, only two brief reports of hepatotoxicity exist. Two patients with type II diabetes mellitus developed an acute hepatitis - like syndro... | {
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"text": "Glyburide",
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{
"text": "sulfonylureas",
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{
"text": "glyburide",
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{
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Systolic pressure variation is greater during hemorrhage than during sodium nitroprusside - induced hypotension in ventilated dogs. The systolic pressure variation (SPV), which is the difference between the maximal and minimal values of the systolic blood pressure (SBP) after one positive - pressure breath, was studied... | {
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"text": "sodium nitroprusside",
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{
"text": "sodium nitroprusside",
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{
"text": "SNP",
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{
... | {
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Drug - induced arterial spasm relieved by lidocaine. Case report. Following major intracranial surgery in a 35 - year - old man, sodium pentothal was intravenously infused to minimize cerebral ischaemia. Intense vasospasm with threatened gangrene arose in the arm used for the infusion. Since the cranial condition precl... | {
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{
"text": "lidocaine",
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{
"text": "sodium pentothal",
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"end": 145
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{
"text": "lidocaine",
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],
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Cerebral blood flow and metabolism during isoflurane - induced hypotension in patients subjected to surgery for cerebral aneurysms. Cerebral blood flow and cerebral metabolic rate for oxygen were measured during isoflurane - induced hypotension in 10 patients subjected to craniotomy for clipping of a cerebral aneurysm.... | {
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{
"text": "isoflurane",
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"end": 52
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{
"text": "oxygen",
"start": 184,
"end": 190
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{
"text": "isoflurane",
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"end": 222
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{
"text": "x... | {
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Allergic reaction to 5 - fluorouracil infusion. An allergic reaction consisting of angioneurotic edema secondary to continuous infusion 5 - fluorouracil occurred in a patient with recurrent carcinoma of the oral cavity, cirrhosis, and cisplatin - induced impaired renal function. This reaction occurred during the sixth ... | {
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"text": "5 - fluorouracil",
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{
"text": "5 - fluorouracil",
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{
"text": "cisplatin",
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{
... | {
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Amiodarone - induced sinoatrial block. We observed sinoatrial block due to chronic amiodarone administration in a 5 - year - old boy with primary cardiomyopathy, Wolff - Parkinson - White syndrome and supraventricular tachycardia. Reduction in the dosage of amiodarone resulted in the disappearance of the sinoatrial blo... | {
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"text": "Amiodarone",
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{
"text": "amiodarone",
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{
"text": "amiodarone",
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... | {
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Possible teratogenicity of sulphasalazine. Three infants, born of two mothers with inflammatory bowel disease who received treatment with sulphasalazine throughout pregnancy, were found to have major congenital anomalies. In the singleton pregnancy, the mother had ulcerative colitis, and the infant, a male, had coarcta... | {
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"text": "sulphasalazine",
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{
"text": "sulphasalazine",
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{
"text": "sulphasalazine",
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],
... | {
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Veno - occlusive liver disease after dacarbazine therapy (DTIC) for melanoma. A case of veno - occlusive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant clinical course from start of symptoms until death. At autopsy the liver was enlarged and firm... | {
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"text": "dacarbazine",
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"end": 48
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{
"text": "DTIC",
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{
"text": "dacarbazine",
"start": 151,
"end": 162
},
{
"text": "DTI... | {
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A case of tardive dyskinesia caused by metoclopramide. Abnormal involuntary movements appeared in the mouth, tongue, neck and abdomen of a 64 - year - old male patient after he took metoclopramide for gastrointestinal disorder in a regimen of 30 mg per day for a total of about 260 days. The symptoms exacerbated to a ma... | {
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"text": "metoclopramide",
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{
"text": "metoclopramide",
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{
"text": "metoclopramide",
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],
... | {
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Further observations on the electrophysiologic effects of oral amiodarone therapy. A case is presented of a reversible intra - Hisian block occurring under amiodarone treatment for atrial tachycardia in a patient without clear intraventricular conduction abnormalities. His bundle recordings showed an atrial tachycardia... | {
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{
"text": "amiodarone",
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{
"text": "amiodarone",
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"end": 166
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{
"text": "amiodarone",
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"end": 453
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{
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Busulfan - induced hemorrhagic cystitis. A case of a busulfan - induced hemorrhage cystitis is reported. Spontaneous resolution occurred following cessation of the drug. The similarity between the histologic appearances of busulfan cystitis and both radiation and cyclophosphamide - induced cystitis is discussed and the... | {
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"text": "Busulfan",
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{
"text": "busulfan",
"start": 53,
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{
"text": "busulfan",
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"end": 231
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{
"text": "cycloph... | {
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Rebound hypertensive after sodium nitroprusside prevented by saralasin in rats. The role of the renin - - angiotensin system in the maintenance of blood pressure during halothane anesthesia and sodium nitroprusside (SNP) - induced hypotension was evaluated. Control rats received halothane anesthesia (1 MAC) for one hou... | {
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{
"text": "sodium nitroprusside",
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"end": 47
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{
"text": "saralasin",
"start": 61,
"end": 70
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{
"text": "angiotensin",
"start": 106,
"end": 117
},
{
... | {
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Toxic hepatitis induced by antithyroid drugs: four cases including one with cross - reactivity between carbimazole and benzylthiouracil. OBJECTIVE: This study was conducted to assess the occurrence of hepatic adverse effects encountered with antithyroid drugs. METHODS: Retrospective review of medical records of 236 pat... | {
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"chemical": [
{
"text": "carbimazole",
"start": 103,
"end": 114
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{
"text": "benzylthiouracil",
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"end": 135
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{
"text": "carbimazole",
"start": 608,
"end": 619
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{
... | {
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Study of the role of vitamin B12 and folinic acid supplementation in preventing hematologic toxicity of zidovudine. A prospective, randomized study was conducted to evaluate the role of vitamin B12 and folinic acid supplementation in preventing zidovudine (ZDV) - induced bone marrow suppression. Seventy - five human im... | {
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"text": "vitamin B12",
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{
"text": "folinic acid",
"start": 37,
"end": 49
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{
"text": "zidovudine",
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"end": 114
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Acute confusion induced by a high - dose infusion of 5 - fluorouracil and folinic acid. A 61 - year - old man was treated with combination chemotherapy incorporating cisplatinum, etoposide, high - dose 5 - fluorouracil (2, 250 mg / m2 / 24 hours) and folinic acid for an inoperable gastric adenocarcinoma. He developed a... | {
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{
"text": "5 - fluorouracil",
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{
"text": "folinic acid",
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"end": 86
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{
"text": "cisplatinum",
"start": 166,
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{
... | {
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Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report. Carbamazepine was switched to its 10 - keto analogue oxcarbazepine among six difficult - to - treat schizophrenic or organic psychotic patients using concomitantly haloperidol, chlorpromazine or clozapine. This chang... | {
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{
"text": "carbamazepine",
"start": 20,
"end": 33
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{
"text": "oxcarbazepine",
"start": 37,
"end": 50
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{
"text": "Carbamazepine",
"start": 104,
"end": 117
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{
... | {
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Erythema multiforme and hypersensitivity myocarditis caused by ampicillin. OBJECTIVE: To report a case of erythema multiforme and hypersensitivity myocarditis caused by ampicillin. CASE SUMMARY: A 13 - year - old boy was treated with ampicillin and gentamicin because of suspected septicemia. Medications were discontinu... | {
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{
"text": "ampicillin",
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{
"text": "ampicillin",
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"end": 179
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{
"text": "ampicillin",
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"end": 244
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Immediate allergic reactions to amoxicillin. A large group of patients with suspected allergic reactions to beta - lactam antibiotics was evaluated. A detailed clinical history, together with skin tests, RAST (radioallergosorbent test), and controlled challenge tests, was used to establish whether patients allergic to ... | {
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"text": "amoxicillin",
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{
"text": "beta - lactam",
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{
"text": "beta - lactam",
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"end": 333
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{
... | {
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Persistent paralysis after prolonged use of atracurium in the absence of corticosteroids. Neuromuscular blocking agents (NMBAs) are often used for patients requiring prolonged mechanical ventilation. Reports of persistent paralysis after the discontinuance of these drugs have most often involved aminosteroid - based NM... | {
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{
"text": "atracurium",
"start": 44,
"end": 54
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{
"text": "vecuronium bromide",
"start": 332,
"end": 350
},
{
"text": "Atracurium besylate",
"start": 410,
"end": 429
},
... | {
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Habitual use of acetaminophen as a risk factor for chronic renal failure: a comparison with phenacetin. Six epidemiologic studies in the United States and Europe indicate that habitual use of phenacetin is associated with the development of chronic renal failure and end - stage renal disease (ESRD), with a relative ris... | {
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"text": "acetaminophen",
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{
"text": "phenacetin",
"start": 92,
"end": 102
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{
"text": "phenacetin",
"start": 192,
"end": 202
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Reduction of heparan sulphate - associated anionic sites in the glomerular basement membrane of rats with streptozotocin - induced diabetic nephropathy. Heparan sulphate - associated anionic sites in the glomerular basement membrane were studied in rats 8 months after induction of diabetes by streptozotocin and in age ... | {
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"chemical": [
{
"text": "heparan sulphate",
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{
"text": "streptozotocin",
"start": 106,
"end": 120
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{
"text": "Heparan sulphate",
"start": 153,
"end": 169
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... | {
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Effect of some anticancer drugs and combined chemotherapy on renal toxicity. The nephrotoxic action of anticancer drugs such as nitrogranulogen (NG), methotrexate (MTX), 5 - fluorouracil (5 - FU) and cyclophosphamide (CY) administered alone or in combination [MTX + 5 - FU + CY (CMF)] was evaluated in experiments on Wis... | {
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{
"text": "nitrogranulogen",
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"end": 143
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{
"text": "NG",
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"end": 147
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{
"text": "methotrexate",
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Lithium - associated cognitive and functional deficits reduced by a switch to divalproex sodium: a case series. BACKGROUND: Lithium remains a first - line treatment for the acute and maintenance treatment of bipolar disorder. Although much has been written about the management of the more common adverse effects of lith... | {
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{
"text": "Lithium",
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{
"text": "divalproex sodium",
"start": 78,
"end": 95
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{
"text": "Lithium",
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"end": 131
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{
"text": "... | {
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Treatment of previously treated metastatic breast cancer by mitoxantrone and 48 - hour continuous infusion of high - dose 5 - FU and leucovorin (MFL): low palliative benefit and high treatment - related toxicity. For previously treated advanced breast cancer, there is no standard second - line therapy. Combination chem... | {
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{
"text": "mitoxantrone",
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{
"text": "5 - FU",
"start": 122,
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{
"text": "leucovorin",
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"text": ... | {
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Upregulation of the expression of vasopressin gene in the paraventricular and supraoptic nuclei of the lithium - induced diabetes insipidus rat. The expression of arginine vasopressin (AVP) gene in the paraventricular (PVN) and supraoptic nuclei (SON) was investigated in rats with lithium (Li) - induced polyuria, using... | {
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"chemical": [
{
"text": "vasopressin",
"start": 34,
"end": 45
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{
"text": "lithium",
"start": 103,
"end": 110
},
{
"text": "arginine vasopressin",
"start": 163,
"end": 183
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{
... | {
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Suxamethonium - induced cardiac arrest and death following 5 days of immobilization. The present report describes a case of cardiac arrest and subsequent death as a result of hyperkalaemia following the use of suxamethonium in a 23 - year - old Malawian woman. Five days after the onset of the symptoms of meningitis, th... | {
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"chemical": [
{
"text": "Suxamethonium",
"start": 0,
"end": 13
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{
"text": "suxamethonium",
"start": 210,
"end": 223
},
{
"text": "suxamethonium",
"start": 426,
"end": 439
},
{
... | {
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An unusual toxic reaction to axillary block by mepivacaine with adrenaline. An increase in blood pressure, accompanied by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, was observed in an elderly, ASA classification group II, cardiovascularly medicated male, 12 min after performance ... | {
"entities": {
"chemical": [
{
"text": "mepivacaine",
"start": 47,
"end": 58
},
{
"text": "adrenaline",
"start": 64,
"end": 74
},
{
"text": "mepivacaine",
"start": 343,
"end": 354
},
{
"text"... | {
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},
{
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Clinical and histopathologic examination of renal allografts treated with tacrolimus (FK506) for at least one year. BACKGROUND: We clinically and pathologically analyzed renal allografts from 1 9 renal transplant patients treated with tacrolimus (FK506) for more than 1 year. METHODS: Twenty - six renal allograft biopsy... | {
"entities": {
"chemical": [
{
"text": "tacrolimus",
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"end": 84
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{
"text": "FK506",
"start": 86,
"end": 91
},
{
"text": "tacrolimus",
"start": 235,
"end": 245
},
{
"text": "FK50... | {
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Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the acetylcholine releaser PG - 9. The effects of PG - 9 (3alpha - tropyl 2 - (p - bromophenyl) propionate), the acetylcholine releaser, on memory processes and nerve growth factor (NGF) synthesis were evaluated. In the mouse passive - a... | {
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"chemical": [
{
"text": "acetylcholine",
"start": 87,
"end": 100
},
{
"text": "PG - 9",
"start": 110,
"end": 116
},
{
"text": "PG - 9",
"start": 133,
"end": 139
},
{
"text": "3... | {
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{
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Angioedema due to ACE inhibitors: common and inadequately diagnosed. The estimated incidence of angioedema during angiotensin - converting enzyme (ACE) inhibitor treatment is between 1 and 7 per thousand patients. This potentially serious adverse effect is often preceded by minor manifestations that may serve as a warn... | {
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"chemical": [
{
"text": "ACE inhibitors",
"start": 18,
"end": 32
},
{
"text": "angiotensin - converting enzyme (ACE) inhibitor",
"start": 114,
"end": 161
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],
"disease": [
{
"text": "Angioedema",
... | {
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{
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Recurarization in the recovery room. A case of recurarization in the recovery room is reported. Accumulation of atracurium in the intravenous line led to recurarization after flushing the line in the recovery room. A respiratory arrest with severe desaturation and bradycardia occurred. Circumstances leading to this eve... | {
"entities": {
"chemical": [
{
"text": "atracurium",
"start": 112,
"end": 122
}
],
"disease": [
{
"text": "respiratory arrest",
"start": 217,
"end": 235
},
{
"text": "desaturation",
"start": 248,
"end": ... | {
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"label": "chemical",
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Recurrent use of newer oral contraceptives and the risk of venous thromboembolism. The epidemiological studies that assessed the risk of venous thromboembolism (VTE) associated with newer oral contraceptives (OC) did not distinguish between patterns of OC use, namely first - time users, repeaters and switchers. Data fr... | {
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"text": "oral contraceptives",
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{
"text": "oral contraceptives",
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{
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{
... | {
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Development of apomorphine - induced aggressive behavior: comparison of adult male and female Wistar rats. The development of apomorphine - induced (1. 0 mg / kg s. c. once daily) aggressive behavior of adult male and female Wistar rats obtained from the same breeder was studied in two consecutive sets. In male animals... | {
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{
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{
"text": "apomorphine",
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Serotonergic antidepressants and urinary incontinence. Many new serotonergic antidepressants have been introduced over the past decade. Although urinary incontinence is listed as one side effect of these drugs in their package inserts there is only one report in the literature. This concerns 2 male patients who experie... | {
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{
"text": "serotonergic antidepressants",
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"end": 92
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{
"text": "venlafaxine",
"start": 351,
"end": 3... | {
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Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. Centrally acting alpha - 2 adrenergic agonists are one of several pharmacologic agents used in the treatment of spasticity related to disorders of the central nervous system.... | {
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{
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{
"text": "angiotensin",
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Peritubular capillary basement membrane reduplication in allografts and native kidney disease: a clinicopathologic study of 278 consecutive renal specimens. BACKGROUND: An association has been found between transplant glomerulopathy (TG) and reduplication of peritubular capillary basement membranes (PTCR). Although suc... | {
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"text": "cocaine",
"start": 1259,
"end": 1266
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],
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"end": 93
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{
"text": "transplant glomerulopathy",
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"... | {
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Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti - cocaine effects in mice. Cocaine' s ability to interact with sigma receptors suggests that these proteins mediate some of its behavioral effects. Therefore, three novel sigma receptor ligands wi... | {
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"text": "BD1008",
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{
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"end": 83
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{
"text": "cocaine",
"start": 126,
"end": 133
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Pharmacokinetic / pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog. 1. Torsades de pointes (TDP) is a potentially fatal ventricular tachycardia associated with increases in QT interval and monophasic action potential duration (MAPD)... | {
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"text": "E4031",
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"end": 68
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{
"text": "cisapride",
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"end": 79
},
{
"text": "terfenadine",
"start": 81,
"end": 92
},
{
"text": "terodi... | {
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Fatal myeloencephalopathy due to accidental intrathecal vincristin administration: a report of two cases. We report on two fatal cases of accidental intrathecal vincristine instillation in a 5 - year old girl with recurrent acute lymphoblastic leucemia and a 57 - year old man with lymphoblastic lymphoma. The girl died ... | {
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{
"text": "vincristin",
"start": 56,
"end": 66
},
{
"text": "vincristine",
"start": 161,
"end": 172
},
{
"text": "vincristine",
"start": 382,
"end": 393
},
{
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Intravenous administration of prochlorperazine by 15 - minute infusion versus 2 - minute bolus does not affect the incidence of akathisia: a prospective, randomized, controlled trial. STUDY OBJECTIVE: We sought to compare the rate of akathisia after administration of intravenous prochlorperazine as a 2 - minute bolus o... | {
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"text": "prochlorperazine",
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{
"text": "prochlorperazine",
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"end": 296
},
{
"text": "prochlorperazine",
"start": 526,
"end": 542
},
... | {
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Antithymocyte globulin in the treatment of D - penicillamine - induced aplastic anemia. A patient who received antithymocyte globulin therapy for aplastic anemia due to D - penicillamine therapy is described. Bone marrow recovery and peripheral blood recovery were complete 1 month and 3 months, respectively, after trea... | {
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"chemical": [
{
"text": "Antithymocyte globulin",
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"end": 22
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{
"text": "D - penicillamine",
"start": 43,
"end": 60
},
{
"text": "antithymocyte globulin",
"start": 111,
"end": 133
... | {
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The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal seizure - prone and withdrawal seizure - resistant selected mouse lines. BACKGROUND: The septo - hippocampal cholinergic pathway has been implicated in epileptogenesis, and genetic factors influence the respo... | {
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{
"text": "acetylcholine",
"start": 37,
"end": 50
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{
"text": "alcohol",
"start": 408,
"end": 415
},
{
"text": "alcohol",
"start": 512,
"end": 519
},
{
"text": "... | {
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Prenatal dexamethasone programs hypertension and renal injury in the rat. Dexamethasone is frequently administered to the developing fetus to accelerate pulmonary development. The purpose of the present study was to determine if prenatal dexamethasone programmed a progressive increase in blood pressure and renal injury... | {
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{
"text": "dexamethasone",
"start": 9,
"end": 22
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{
"text": "dexamethasone",
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"end": 251
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{
"text": "dexamethasone",
"start": 411,
"end": 424
},
{
... | {
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The risk of venous thromboembolism in women prescribed cyproterone acetate in combination with ethinyl estradiol: a nested cohort analysis and case - control study. BACKGROUND: Cyproterone acetate combined with ethinyl estradiol (CPA / EE) is licensed in the UK for the treatment of women with acne and hirsutism and is ... | {
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{
"text": "cyproterone acetate",
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"end": 74
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{
"text": "ethinyl estradiol",
"start": 95,
"end": 112
},
{
"text": "Cyproterone acetate",
"start": 177,
"end": 196
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Pseudoacromegaly induced by the long - term use of minoxidil. Acromegaly is an endocrine disorder caused by chronic excessive growth hormone secretion from the anterior pituitary gland. Significant disfiguring changes occur as a result of bone, cartilage, and soft tissue hypertrophy, including the thickening of the ski... | {
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"chemical": [
{
"text": "minoxidil",
"start": 51,
"end": 60
},
{
"text": "minoxidil",
"start": 634,
"end": 643
},
{
"text": "minoxidil",
"start": 741,
"end": 750
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],
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... | {
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Combined androgen blockade - induced anemia in prostate cancer patients without bone involvement. BACKGROUND: To determine the onset and extent of combined androgen blockade (CAB) - induced anemia in prostate cancer patients without bone involvement. PATIENTS AND METHODS: Forty - two patients with biopsy - proven prost... | {
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"chemical": [
{
"text": "leuprolide acetate",
"start": 453,
"end": 471
},
{
"text": "LHRH - A",
"start": 473,
"end": 481
},
{
"text": "flutamide",
"start": 536,
"end": 545
},
{
... | {
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Reversible dilated cardiomyopathy related to amphotericin B therapy. We describe a patient who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abnormalities and heart failure resolved af... | {
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{
"text": "amphotericin B",
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"end": 59
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{
"text": "amphotericin B",
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"end": 211
},
{
"text": "AmB",
"start": 213,
"end": 216
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Risks of the consumption of beverages containing quinine. Although the United States Food and Drug Administration banned its use for nocturnal leg cramps due to lack of safety and efficacy, quinine is widely available in beverages including tonic water and bitter lemon. Numerous anecdotal reports suggest that products ... | {
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"text": "quinine",
"start": 49,
"end": 56
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{
"text": "quinine",
"start": 190,
"end": 197
},
{
"text": "quinine",
"start": 331,
"end": 338
},
{
"text": "quinin... | {
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Organophosphate - induced convulsions and prevention of neuropathological damages. Such organophosphorus (OP) compounds as diisopropylfluorophosphate (DFP), sarin and soman are potent inhibitors of acetylcholinesterases (AChEs) and butyrylcholinesterases (BChEs). The acute toxicity of OPs is the result of their irrever... | {
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"text": "Organophosphate",
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{
"text": "organophosphorus",
"start": 88,
"end": 104
},
{
"text": "OP",
"start": 106,
"end": 108
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{
"text... | {
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},
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Differential modulation by estrogen of alpha2 - adrenergic and I1 - imidazoline receptor - mediated hypotension in female rats. We have recently shown that estrogen negatively modulates the hypotensive effect of clonidine (mixed alpha2 - / I1 - receptor agonist) in female rats and implicates the cardiovascular autonomi... | {
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{
"text": "estrogen",
"start": 27,
"end": 35
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{
"text": "imidazoline",
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"end": 79
},
{
"text": "estrogen",
"start": 156,
"end": 164
},
{
"text": "cl... | {
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Cardioprotective effect of tincture of Crataegus on isoproterenol - induced myocardial infarction in rats. Tincture of Crataegus (TCR), an alcoholic extract of the berries of hawthorn (Crataegus oxycantha), is used in herbal and homeopathic medicine. The present study was done to investigate the protective effect of TC... | {
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{
"text": "tincture of Crataegus",
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"end": 48
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{
"text": "isoproterenol",
"start": 52,
"end": 65
},
{
"text": "Tincture of Crataegus",
"start": 107,
"end": 128
},... | {
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},
{
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Safety and adverse effects associated with raloxifene: multiple outcomes of raloxifene evaluation. OBJECTIVE: To examine the effect of raloxifene on major adverse events that occur with postmenopausal estrogen therapy or tamoxifen. METHODS: The Multiple Outcomes of Raloxifene Evaluation, a multicenter, randomized, doub... | {
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"chemical": [
{
"text": "raloxifene",
"start": 43,
"end": 53
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{
"text": "raloxifene",
"start": 76,
"end": 86
},
{
"text": "raloxifene",
"start": 135,
"end": 145
},
{
"text": ... | {
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Ceftriaxone - associated biliary pseudolithiasis in paediatric surgical patients. It is well known that ceftriaxone leads to pseudolithiasis in some patients. Clinical and experimental studies also suggest that situations causing gallbladder dysfunction, such as fasting, may have a role for the development of pseudolit... | {
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"chemical": [
{
"text": "Ceftriaxone",
"start": 0,
"end": 11
},
{
"text": "ceftriaxone",
"start": 104,
"end": 115
},
{
"text": "ceftriaxone",
"start": 469,
"end": 480
},
{
"tex... | {
"entities": [
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"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
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Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose. The illicit use of cocaine continues in epidemic proportions and treatment for cocaine overdose remains elusive. Current protein - based technology offers a new therapeutic venue by which antibodies bind the drug in the ... | {
"entities": {
"chemical": [
{
"text": "GNC92H2",
"start": 50,
"end": 57
},
{
"text": "cocaine",
"start": 119,
"end": 126
},
{
"text": "GNC92H2",
"start": 420,
"end": 427
},
{
"text": "cocain... | {
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The effects of short - term raloxifene therapy on fibrinolysis markers: TAFI, tPA, and PAI - 1. BACKGROUND: Markers of fibrinolysis, thrombin - activatable fibrinolysis inhibitor (TAFI), tissue - type plasminogen activator (tPA), and plasminogen activator inhibitor - 1 (PAI - 1) levels were studied for the evaluation o... | {
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"chemical": [
{
"text": "raloxifene",
"start": 28,
"end": 38
},
{
"text": "raloxifene",
"start": 346,
"end": 356
},
{
"text": "raloxifene hydrochloride",
"start": 566,
"end": 590
},
{
... | {
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},
{
"label": "disease",
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Ketoconazole induced torsades de pointes without concomitant use of QT interval - prolonging drug. Ketoconazole is not known to be proarrhythmic without concomitant use of QT interval - prolonging drugs. We report a woman with coronary artery disease who developed a markedly prolonged QT interval and torsades de pointe... | {
"entities": {
"chemical": [
{
"text": "Ketoconazole",
"start": 0,
"end": 12
},
{
"text": "Ketoconazole",
"start": 99,
"end": 111
},
{
"text": "ketoconazole",
"start": 341,
"end": 353
},
{
"t... | {
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},
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Pharmacological evidence for the potential of Daucus carota in the management of cognitive dysfunctions. The present study was aimed at investigating the effects of Daucus carota seeds on cognitive functions, total serum cholesterol levels and brain cholinesterase activity in mice. The ethanolic extract of Daucus carot... | {
"entities": {
"chemical": [
{
"text": "cholesterol",
"start": 221,
"end": 232
},
{
"text": "extract of Daucus carota seeds",
"start": 297,
"end": 327
},
{
"text": "DCE",
"start": 329,
"end": 332
},
... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
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Cauda equina syndrome after epidural steroid injection: a case report. OBJECTIVE: Conventional treatment methods of lumbusacral radiculopathy are physical therapy, epidural steroid injections, oral medications, and spinal manipulative therapy. Cauda equina syndrome is a rare complication of epidural anesthesia. The fol... | {
"entities": {
"chemical": [
{
"text": "steroid",
"start": 37,
"end": 44
},
{
"text": "steroid",
"start": 173,
"end": 180
},
{
"text": "triamcinolone",
"start": 410,
"end": 423
},
{
"text": "... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
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High - dose testosterone is associated with atherosclerosis in postmenopausal women. OBJECTIVES: To study the long - term effects of androgen treatment on atherosclerosis in postmenopausal women. METHODS: In a population - based study in 513 naturally postmenopausal women aged 54 - 67 years, we studied the association ... | {
"entities": {
"chemical": [
{
"text": "testosterone",
"start": 12,
"end": 24
},
{
"text": "estrogen",
"start": 385,
"end": 393
},
{
"text": "testosterone",
"start": 396,
"end": 408
},
{
"tex... | {
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},
{
"label": "disease",
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Sirolimus - associated proteinuria and renal dysfunction. Sirolimus is a novel immunosuppressant with potent antiproliferative actions through its ability to inhibit the raptor - containing mammalian target of rapamycin protein kinase. Sirolimus represents a major therapeutic advance in the prevention of acute renal al... | {
"entities": {
"chemical": [
{
"text": "Sirolimus",
"start": 0,
"end": 9
},
{
"text": "Sirolimus",
"start": 58,
"end": 67
},
{
"text": "rapamycin",
"start": 210,
"end": 219
},
{
"text": "Siro... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
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Progressive myopathy with up - regulation of MHC - I associated with statin therapy. Statins can cause a necrotizing myopathy and hyperCKaemia which is reversible on cessation of the drug. What is less well known is a phenomenon whereby statins may induce a myopathy, which persists or may progress after stopping the dr... | {
"entities": {
"chemical": [
{
"text": "statin",
"start": 69,
"end": 75
},
{
"text": "Statins",
"start": 85,
"end": 92
},
{
"text": "statins",
"start": 237,
"end": 244
},
{
"text": "prednisol... | {
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"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
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Direct inhibition of cardiac hyperpolarization - activated cyclic nucleotide - gated pacemaker channels by clonidine. BACKGROUND: Inhibition of cardiac sympathetic tone represents an important strategy for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic heart failure. Acti... | {
"entities": {
"chemical": [
{
"text": "cyclic nucleotide",
"start": 59,
"end": 76
},
{
"text": "clonidine",
"start": 107,
"end": 116
},
{
"text": "clonidine",
"start": 441,
"end": 450
},
{
"... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
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Influence of smoking on developing cochlea. Does smoking during pregnancy affect the amplitudes of transient evoked otoacoustic emissions in newborns? OBJECTIVE: Maternal tobacco smoking has negative effects on fetal growth. The influence of smoking during pregnancy on the developing cochlea has not been estimated, alt... | {
"entities": {
"chemical": [
{
"text": "smoking",
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{
"text": "smoking",
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{
"text": "smoking",
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{
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Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism. Autism is a neurodevelopmental disorder presenting before 3 years of age with deficits in communication and social skills and repetitive behaviors. In addition to genetic influences, recent studies sugg... | {
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{
"text": "terbutaline",
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{
"text": "Terbutaline",
"start": 394,
"end": 405
},
{
"text": "terbutaline",
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{
"te... | {
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Acute myocarditis associated with clozapine. OBJECTIVE: A case of acute myocarditis associated with the commencement of clozapine is described, highlighting the onset, course and possible contributing factors. There is an urgent need to raise awareness about this potentially fatal complication of clozapine use. RESULTS... | {
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{
"text": "clozapine",
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{
"text": "clozapine",
"start": 120,
"end": 129
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{
"text": "clozapine",
"start": 298,
"end": 307
},
{
"text": "... | {
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Encephalopathy induced by levetiracetam added to valproate. BACKGROUND: We report on the manifestation of a levetiracetam (LEV) - induced encephalopathy. FINDINGS: A 28 - year - old man suffering from idiopathic epilepsy with generalized seizures was treated with LEV (3000 mg) added to valproate (VPA) (2000 mg). Freque... | {
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{
"text": "levetiracetam",
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"end": 39
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{
"text": "valproate",
"start": 49,
"end": 58
},
{
"text": "levetiracetam",
"start": 108,
"end": 121
},
{
"te... | {
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Norepinephrine signaling through beta - adrenergic receptors is critical for expression of cocaine - induced anxiety. BACKGROUND: Cocaine is a widely abused psychostimulant that has both rewarding and aversive properties. While the mechanisms underlying cocaine' s rewarding effects have been studied extensively, less a... | {
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{
"text": "Norepinephrine",
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"end": 14
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{
"text": "cocaine",
"start": 91,
"end": 98
},
{
"text": "Cocaine",
"start": 130,
"end": 137
},
{
"text": "co... | {
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Clonidine for attention - deficit / hyperactivity disorder: II. ECG changes and adverse events analysis. OBJECTIVE: To examine the safety and tolerability of clonidine used alone or with methylphenidate in children with attention - deficit / hyperactivity disorder (ADHD). METHOD: In a 16 - week multicenter, double - bl... | {
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"text": "Clonidine",
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{
"text": "clonidine",
"start": 158,
"end": 167
},
{
"text": "methylphenidate",
"start": 187,
"end": 202
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Thalidomide has limited single - agent activity in relapsed or refractory indolent non - Hodgkin lymphomas: a phase II trial of the Cancer and Leukemia Group B. Thalidomide is an immunomodulatory agent with demonstrated activity in multiple myeloma, mantle cell lymphoma and lymphoplasmacytic lymphoma. Its activity is b... | {
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"text": "Thalidomide",
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{
"text": "Thalidomide",
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"end": 172
},
{
"text": "thalidomide",
"start": 541,
"end": 552
},
{
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Intracavernous epinephrine: a minimally invasive treatment for priapism in the emergency department. Priapism is the prolonged erection of the penis in the absence of sexual arousal. A 45 - year - old man, an admitted frequent cocaine user, presented to the Emergency Department (ED) on two separate occasions with a his... | {
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{
"text": "epinephrine",
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{
"text": "cocaine",
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"end": 234
},
{
"text": "cocaine",
"start": 343,
"end": 350
},
{
"text": "ep... | {
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Effect of green tea and vitamin E combination in isoproterenol induced myocardial infarction in rats. The present study was aimed to investigate the combined effects of green tea and vitamin E on heart weight, body weight, serum marker enzymes, lipid peroxidation, endogenous antioxidants and membrane bound ATPases in i... | {
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"text": "green tea",
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{
"text": "vitamin E",
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"end": 33
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{
"text": "isoproterenol",
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},
{
"text": "... | {
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Development of ocular myasthenia during pegylated interferon and ribavirin treatment for chronic hepatitis C. A 63 - year - old male experienced sudden diplopia after 9 weeks of administration of pegylated interferon (IFN) alpha - 2b and ribavirin for chronic hepatitis C (CHC). Ophthalmologic examinations showed ptosis... | {
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{
"text": "pegylated interferon",
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{
"text": "ribavirin",
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"end": 74
},
{
"text": "pegylated interferon (IFN) alpha - 2b",
"start": 196,
"end": 2... | {
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The glycine transporter - 1 inhibitor SSR103800 displays a selective and specific antipsychotic - like profile in normal and transgenic mice. Schizophrenia has been initially associated with dysfunction in dopamine neurotransmission. However, the observation that antagonists of the glutamate N - methyl - D - aspartate ... | {
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"text": "glycine",
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{
"text": "SSR103800",
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},
{
"text": "dopamine",
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"end": 214
},
{
"text": "glutam... | {
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Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia - induced hypotension. BACKGROUND: Vasopressor agents are used to correct anesthesia - induced hypotension. We describe the effect of phenylephrine and ephedrine on frontal lobe oxygenation (S (c) O (2)) following anesthesia - induced... | {
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{
"text": "Phenylephrine",
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{
"text": "ephedrine",
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"end": 31
},
{
"text": "phenylephrine",
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"end": 233
},
{
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A novel, multiple symptom model of obsessive - compulsive - like behaviors in animals. BACKGROUND: Current animal models of obsessive - compulsive disorder (OCD) typically involve acute, drug - induced symptom provocation or a genetic association with stereotypies or anxiety. None of these current models demonstrate mu... | {
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{
"text": "antidepressant",
"start": 404,
"end": 418
},
{
"text": "clomipramine",
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"end": 431
},
{
"text": "Clomipramine",
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"end": 536
},
{
... | {
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Late recovery of renal function in a woman with the hemolytic uremic syndrome. A case is reported of the hemolytic uremic syndrome (HUS) in a woman taking oral contraceptives. She was treated with heparin, dipyridamole and hemodialysis; and after more than three months, her urinary output rose above 500 ml; and six mon... | {
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{
"text": "oral contraceptives",
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},
{
"text": "heparin",
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"end": 204
},
{
"text": "dipyridamole",
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"end": 218
}
],
"d... | {
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Effects of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine - induced myocardial injury in dogs. A reproducible model for producing diffuse myocardial injury (epinephrine infusion) has been developed to study the cardioprotective effects of agents or maneuvers which might alter the evolution of acu... | {
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{
"text": "acetylsalicylic acid",
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{
"text": "dipyridamole",
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"end": 45
},
{
"text": "hydrocortisone",
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"end": 65
},
{
... | {
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Changes in depressive status associated with topical beta - blockers. Depression and sexual dysfunction have been related to side effects of topical beta - blockers. We performed a preliminary study in order to determine any difference between a non selective beta - blocker (timolol) and a selective beta - blocker (bet... | {
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"chemical": [
{
"text": "timolol",
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"end": 283
},
{
"text": "betaxolol",
"start": 317,
"end": 326
},
{
"text": "timolol",
"start": 409,
"end": 416
},
{
"text": "ti... | {
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Long - term follow - up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report. The renal function of 74 children with malignant mesenchymal tumors in complete remission and who have received the same ifosfamide chemotherapy protocol (Int... | {
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{
"text": "ifosfamide",
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{
"text": "ifosfamide",
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},
{
"text": "ifosfamide",
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"end": 525
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Evidence for an involvement of D1 and D2 dopamine receptors in mediating nicotine - induced hyperactivity in rats. Previous studies have suggested that repeated exposure of rats to the drug or to the experimental environment is necessary to observe nicotine - induced locomotor stimulation. In the present study the role... | {
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{
"text": "dopamine",
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{
"text": "nicotine",
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"end": 81
},
{
"text": "nicotine",
"start": 249,
"end": 257
},
{
"text": "nicot... | {
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Neuropsychiatric side effects after the use of mefloquine. This study describes neuropsychiatric side effects in patients after treatment with mefloquine. Reactions consisted mainly of seizures, acute psychoses, anxiety neurosis, and major disturbances of sleep - wake rhythm. Side effects occurred after both therapeuti... | {
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{
"text": "mefloquine",
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{
"text": "mefloquine",
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"end": 153
},
{
"text": "mefloquine",
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"end": 496
},
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Reduction in injection pain using buffered lidocaine as a local anesthetic before cardiac catheterization. Previous reports have suggested that pain associated with the injection of lidocaine is related to the acidic pH of the solution. To determine if the addition of a buffering solution to adjust the pH of lidocaine ... | {
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"chemical": [
{
"text": "lidocaine",
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{
"text": "lidocaine",
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"end": 191
},
{
"text": "lidocaine",
"start": 310,
"end": 319
},
{
"text": "... | {
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Randomized, double - blind trial of mazindol in Duchenne dystrophy. There is evidence that growth hormone may be related to the progression of weakness in Duchenne dystrophy. We conducted a 12 - month controlled trial of mazindol, a putative growth hormone secretion inhibitor, in 83 boys with Duchenne dystrophy. Muscle... | {
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{
"text": "mazindol",
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"end": 44
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{
"text": "mazindol",
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"end": 229
},
{
"text": "mazindol",
"start": 453,
"end": 461
},
{
"text": "Maz... | {
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Pentoxifylline (Trental) does not inhibit dipyridamole - induced coronary hyperemia: implications for dipyridamole - thallium - 201 myocardial imaging. Dipyridamole - thallium - 201 imaging is often performed in patients unable to exercise because of peripheral vascular disease. Many of these patients are taking pentox... | {
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{
"text": "Pentoxifylline",
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{
"text": "Trental",
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"end": 23
},
{
"text": "dipyridamole",
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"end": 54
},
{
"text": ... | {
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Cause of death among patients with Parkinson' s disease: a rare mortality due to cerebral haemorrhage. Causes of death, with special reference to cerebral haemorrhage, among 240 patients with pathologically verified Parkinson' s disease were investigated using the Annuals of the Pathological Autopsy Cases in Japan from... | {
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{
"text": "levodopa",
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"end": 873
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{
"text": "noradrenaline",
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],
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"text": "death",
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... | {
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Tolerance and antiviral effect of ribavirin in patients with Argentine hemorrhagic fever. Tolerance and antiviral effect of ribavirin was studied in 6 patients with Argentine hemorrhagic fever (AHF) of more than 8 days of evolution. Administration of ribavirin resulted in a neutralization of viremia and a drop of endog... | {
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{
"text": "ribavirin",
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{
"text": "ribavirin",
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"end": 133
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{
"text": "ribavirin",
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"end": 260
},
{
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Dipyridamole - induced myocardial ischemia. Angina and ischemic electrocardiographic changes occurred after administration of oral dipyridamole in four patients awaiting urgent myocardial revascularization procedures. To our knowledge, this has not previously been reported as a side effect of preoperative dipyridamole ... | {
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"chemical": [
{
"text": "Dipyridamole",
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{
"text": "dipyridamole",
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{
"text": "dipyridamole",
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"end": 319
},
{
"... | {
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Inhibition of immunoreactive corticotropin - releasing factor secretion into the hypophysial - portal circulation by delayed glucocorticoid feedback. Nitroprusside - induced hypotension evokes ACTH secretion which is primarily mediated by enhanced secretion of immunoreactive corticotropin - releasing factor (irCRF) int... | {
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"chemical": [
{
"text": "Nitroprusside",
"start": 150,
"end": 163
},
{
"text": "arginine vasopressin",
"start": 400,
"end": 420
},
{
"text": "oxytocin",
"start": 425,
"end": 433
},
{
... | {
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Noradrenergic involvement in catalepsy induced by delta 9 - tetrahydrocannabinol. In order to elucidate the role of the catecholaminergic system in the cataleptogenic effect of delta 9 - tetrahydrocannabinol (THC), the effect of pretreatment with 6 - hydroxydopamine (6 - OHDA) or with desipramine and 6 - OHDA and lesio... | {
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"chemical": [
{
"text": "delta 9 - tetrahydrocannabinol",
"start": 50,
"end": 80
},
{
"text": "delta 9 - tetrahydrocannabinol",
"start": 177,
"end": 207
},
{
"text": "THC",
"start": 209,
"end": 21... | {
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{
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Intracranial pressure increases during alfentanil - induced rigidity. Intracranial pressure (ICP) was measured during alfentanil - induced rigidity in rats. Ten rats had arterial, central venous (CVP), and subdural cannulae inserted under halothane anesthesia. The animals were mechanically ventilated to achieve normoca... | {
"entities": {
"chemical": [
{
"text": "alfentanil",
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"end": 49
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{
"text": "alfentanil",
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"end": 128
},
{
"text": "halothane",
"start": 239,
"end": 248
},
{
"text":... | {
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{
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Adverse cardiac effects during induction chemotherapy treatment with cis - platin and 5 - fluorouracil. Survival for patients with advanced head and neck carcinoma and esophageal carcinoma is poor with radiotherapy and / or surgery. Obviously, there is a need for effective chemotherapy. In the present study, cis - plat... | {
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"chemical": [
{
"text": "cis - platin",
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"end": 81
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{
"text": "5 - fluorouracil",
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"end": 102
},
{
"text": "cis - platin",
"start": 310,
"end": 322
},
{
... | {
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Verapamil - induced carbamazepine neurotoxicity. A report of two cases. Two patients with signs of carbamazepine neurotoxicity after combined treatment with verapamil showed complete recovery after discontinuation of the calcium entry blocker. Use of verapamil in combination with carbamazepine should either be avoided ... | {
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{
"text": "Verapamil",
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{
"text": "carbamazepine",
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"end": 33
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{
"text": "carbamazepine",
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"end": 112
},
{
"text"... | {
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Serial studies of auditory neurotoxicity in patients receiving deferoxamine therapy. Visual and auditory neurotoxicity was previously documented in 42 of 89 patients with transfusion - dependent anemia who were receiving iron chelation therapy with daily subcutaneous deferoxamine. Twenty - two patients in the affected ... | {
"entities": {
"chemical": [
{
"text": "deferoxamine",
"start": 63,
"end": 75
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{
"text": "iron",
"start": 221,
"end": 225
},
{
"text": "deferoxamine",
"start": 268,
"end": 280
},
{
"text": ... | {
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},
{
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Flurbiprofen in the treatment of juvenile rheumatoid arthritis. Thirty - four patients with juvenile rheumatoid arthritis, who were treated with flurbiprofen at a maximum dose of 4 mg / kg / day, had statistically significant decreases from baseline in 6 arthritis indices after 12 weeks of treatment. Improvements were ... | {
"entities": {
"chemical": [
{
"text": "Flurbiprofen",
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"end": 12
},
{
"text": "flurbiprofen",
"start": 145,
"end": 157
}
],
"disease": [
{
"text": "juvenile rheumatoid arthritis",
"start": 33,
... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
"description": "A disease, disorder, syndrome, pathological cond... |
The correlation between neurotoxic esterase inhibition and mipafox - induced neuropathic damage in rats. The correlation between neuropathic damage and inhibition of neurotoxic esterase or neuropathy target enzyme (NTE) was examined in rats acutely exposed to Mipafox (N, N' - diisopropylphosphorodiamidofluoridate), a n... | {
"entities": {
"chemical": [
{
"text": "mipafox",
"start": 59,
"end": 66
},
{
"text": "Mipafox",
"start": 260,
"end": 267
},
{
"text": "N, N' - diisopropylphosphorodiamidofluoridate",
"start": 269,
"end": 314
... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
"description": "A disease, disorder, syndrome, pathological cond... |
Cerebral infarction with a single oral dose of phenylpropanolamine. Phenylpropanolamine (PPA), a synthetic sympathomimetic that is structurally similar to amphetamine, is available over the counter in anorectics, nasal congestants, and cold preparations. Its prolonged use or overuse has been associated with seizures, i... | {
"entities": {
"chemical": [
{
"text": "phenylpropanolamine",
"start": 47,
"end": 66
},
{
"text": "Phenylpropanolamine",
"start": 68,
"end": 87
},
{
"text": "PPA",
"start": 89,
"end": 92
},
{
... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
"description": "A disease, disorder, syndrome, pathological cond... |
Treatment of psoriasis with azathioprine. Azathioprine treatment benefited 19 (66%) out of 29 patients suffering from severe psoriasis. Haematological complications were not troublesome and results of biochemical liver function tests remained normal. Minimal cholestasis was seen in two cases and portal fibrosis of a re... | {
"entities": {
"chemical": [
{
"text": "azathioprine",
"start": 28,
"end": 40
},
{
"text": "Azathioprine",
"start": 42,
"end": 54
},
{
"text": "azathioprine",
"start": 406,
"end": 418
}
],
"disease... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
"description": "A disease, disorder, syndrome, pathological cond... |
Maternal lithium and neonatal Ebstein' s anomaly: evaluation with cross - sectional echocardiography. Cross - sectional echocardiography was used to evaluate two neonates whose mothers ingested lithium during pregnancy. In one infant, Ebstein' s anomaly of the tricuspid valve was identified. In the other infant cross -... | {
"entities": {
"chemical": [
{
"text": "lithium",
"start": 9,
"end": 16
},
{
"text": "lithium",
"start": 194,
"end": 201
},
{
"text": "lithium",
"start": 487,
"end": 494
},
{
"text": "lithium... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
"description": "A disease, disorder, syndrome, pathological cond... |
Effects of training on the extent of experimental myocardial infarction in aging rats. The effects of exercise on the severity of isoproterenol - induced myocardial infarction were studied in female albino rats of 20, 40, 60 and 80 weeks of age. The rats were trained to swim for a specific duration and for a particular... | {
"entities": {
"chemical": [
{
"text": "isoproterenol",
"start": 130,
"end": 143
},
{
"text": "isoproterenols",
"start": 464,
"end": 478
}
],
"disease": [
{
"text": "myocardial infarction",
"start": 50,
... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
"description": "A disease, disorder, syndrome, pathological cond... |
Effect of polyethylene glycol 400 on adriamycin toxicity in mice. The effect of a widely used organic solvent, polyethylene glycol 400 (PEG 400), on the toxic action of an acute or chronic treatment with adriamycin (ADR) was evaluated in mice. PEG 400 impressively decreased both acute high - dose and chronic low - dose... | {
"entities": {
"chemical": [
{
"text": "polyethylene glycol 400",
"start": 10,
"end": 33
},
{
"text": "adriamycin",
"start": 37,
"end": 47
},
{
"text": "polyethylene glycol 400",
"start": 111,
"end": 134
}... | {
"entities": [
{
"label": "chemical",
"description": "A chemical substance, including drugs, compounds, elements, ions, metabolites, and other chemical entities mentioned in biomedical text."
},
{
"label": "disease",
"description": "A disease, disorder, syndrome, pathological cond... |
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