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Belongs to the AB hydrolase superfamily.
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MLTSIAERIMYCLTGKTPNSVGPVETSETSDGYDFLEVKPGRVLRVRHILPSCPGDREEEELFEEKNGGQGLVHCKRRITVYRNGQLVIENLGATLRSEILHCRNGNLEPAGTLEVELSDFTSTGNEGGGKESDVPPGKRRKRKPKKVIMVDCQRQVKCCKGTHSDVVLFFIHGVGGSLDIWKEQLDFFSKLGYEVVAPDLVGHGASTAPQIGAAYTFYALAEDMRCIFKRYAKKRNILVGHSYGVSFCTFLAHEYPDLVHKVVMINGGGPTALEPSLCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLREGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPILLVHGMHDKFVPLDEDQRMAEILLITFLKIIEEGSHMVMLECPETVNTLLHEFFLWQPETQNTTAEDTGNE
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Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate. H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein] H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate Inhibited by palmostatin-B. Belongs to the AB hydrolase superfamily.
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MAGVGLAAVPAWVPCRRWGLAAVTFGFHHGLSTLLARKTERAPQWLRACRHKTSISFLSRPDLPNLAYKRLKGKSPGIIFIPGYISNMNGTKALAIEEFCKSLGHAYIRFDYSGVGNSDGNLEECTVGKWRKDVLSIIDDLAEGPQILVGSSLGGWLMFHAAIARPQKVVALVGVATAVDGLVTQFNQLPIETKKEIEMKGVWPMPSKYSEEGVYRIQYSVIKEAEHHCLLHSPIPVKCPVRLLHGMKDDIVPWHTSVQVADRVVSTDVDVILRKNSDHRMKEKADIQLLVYTIDDLIDKLSTIVH
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Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (PubMed:22294686). H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein] H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate Inhibited by palmostatin-B. Belongs to the AB hydrolase superfamily.
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MAVARLAAVAAWVPCRSWGWAAVPFGPHRGLSVLLARIPQRAPRWLPACRQKTSLSFLNRPDLPNLAYKKLKGKSPGIIFIPGYLSYMNGTKALAIEEFCKSLGHACIRFDYSGVGSSDGNSEESTLGKWRKDVLSIIDDLADGPQILVGSSLGGWLMLHAAIARPEKVVALIGVATAADTLVTKFNQLPVELKKEVEMKGVWSMPSKYSEEGVYNVQYSFIKEAEHHCLLHSPIPVNCPIRLLHGMKDDIVPWHTSMQVADRVLSTDVDVILRKHSDHRMREKADIQLLVYTIDDLIDKLSTIVN
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MQPNDITFFQRFQNDILAGRKTITIRDASESHFKAGDVLRVGRFEDDGYFCTIEVTGTSTVTLDTLNEKHAQQENMSLDELKRVIAEIYPNQTQFYVIDFKCL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MQPNDITFFQRFQNDILAGRKTITIRDASESHFKAGDMLRVGRFEDDGYFCTIEVTGTSTVTLDTLNEKHAQQENMSLDELKRVIAEIYPNQTQFYVIDFKCL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MQPNDITFFQRFQNDILAGRKTITIRDASESHFKAGDALRVGRFEDDGYFCTIEVTGTSTVTLDTLNEKHAQQENMSLDELKRVIAEIYPNQTQFYVIDFKCL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MQPNDITFFQRFQNDILAGRKTITIRDASESHFKAGDVLRVGRFEDDGYFCTIEVTGTSTVTLDTLNEKHAQQENMSLDELKRVIAEIYPNQTQFYVIDFKCL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MSREITFFSRFEQDILAGRKTITIRDASESHFQPGEVLRVSRNEDNVFFCQIEVLSVTPVRLDGLTEQHARQENMSLGELKQVIKEIYPGLDELFVITFAKR
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLLSKITFFERFEHDILSGTKTITLRDEAESHVITGQILPVSTFETDRWFCDIQIIDVTPVKLTELTEVHAKQENMTLPQLCDVIAEIYPGLEQLFMIRFRILSQ
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLLNKITFFERFEHDILSGAKTITLRDEAESHVITGQILPVSTFETDRWFCDIQIIDVTPVKLTELTEMHAKQENMTLPQLRDVIAEIYPGLEQLFMIRFRILLQ
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLLNKITFFERFEHDILSGAKTITLRDEAESHVITGQILPVSTFETDRWFCDIQIIDVTPVKLTELTEMHAKQENMTLPQLRDVIAEIYPGLEQLFMIRFMILSQ
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLLNKITFFERFEHDILSGAKTITLRDEAESHVIVGQILPVSTFETERWFCDIQIIDVTPVKLTELTEVHAKQENMTLPQLRDVIAEIYPGLEQLFMIRFRILSQ
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLTEITFFERFEHDILMGKKTITLRNEAESHVIPGQILPVSTFETHRWFCDIQVLEVTPITLSGLTTLHAQQENMTLAELRLVIAEIYPDLEQLYMIRFKVLTK
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLLSKITFFERFEQDILSGAKTITLRDETESHVVAGQILPVSTFETDRWFCDIQIIDVMPVKLTELTDVHAEQENMTLPQLRSVIAEIYPGLEQLYMISFVVL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLTKITFFERFEQDILSGAKTITLRNEAESHVFAGQILPVSTFEADRWFCDIKVIEVVPVLFSALTEQHAAQENMTLPELRRVIQEIYPGLEQLFQIHFCVVNTRAHPIN
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLTKITFFERFEQDILSGAKTITLRDEAESHVFAGQILPVSTFEDDRWFCDIEVIEVVPVLFSELTEQHAAQENMTLPELRRVIQEIYPGLEQLFQIRFCLVQ
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLTKITFFERFEPGILSGAKTITLRDEAESHVFAGQILPVSTFEADRWFCDIEVIDIVPVLFSALTEQHAAQENMTLPELRRVIQEIYPGLEQLFQIRFCLVQ
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MLLSKITFFERFEQDILSGAKTITLRDETESHVVAGQILPVSTFETDRWFCDIQIIDVMPVKLTELTDVHAEQENMTLPQLRSVIAEIYPGLEQLYMISFVVL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MQPNDITFFQRFQDDIMAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELIKVIADIYPGQTQFYVIEFKCL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MQPNDITFSQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELIKVIADIYPGQTQFYVIEFKCL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELKKVIADIYPGQTQFYVIEFKCL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELIKVIADIYPGQTQFYVIEFKCL
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Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C). H2O + N(4)-acetylcytidine = acetate + cytidine + H(+) H2O + N(4)-acetyl-2'-deoxycytidine = 2'-deoxycytidine + acetate + H(+) H2O + N(4)-acetylcytosine = acetate + cytosine + H(+) Belongs to the N(4)-acetylcytidine amidohydrolase family.
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MTAPTTMTFFERFETDILSGKKTITIRDESERNYQPGSVVEVSTLEQGRVFCNLKIISVEPILFYDLGEFHAQQENMTLDVLKDVIQDIYPGISQLYVVSYELV
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GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1. Interacts with ITGB1; required for ITGB1 recycling. PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes. Only one PH domain of one ACAP1 dimer inserts into the membrane, while the other PH domain acts primaryly to interact with adjacent ACAP1 dimers (By similarity). The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions (By similarity). Cells overexpressing Acap1 show accumulation of an electron dense coat containing Acap1 and Cltc on internal membranes as well as accumulation of Tfrc in pericentriolar recycling endosomes. Adipocytes with reduced level of Acap1 or Cltc fail to transport SLC2A4/GLUT4 from recycling endosomes to the cell surface upon insulin stimulation.
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MTVKLDFEECLKDSPRFRASIELVETEVSELETRLEKLLKLGSCLLESGQHYLAAGRAFVVGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFREARRDFWRGAENLEAALTHNAEVPRRRVQEAEEAGTALRTARAGYRSRALDYALQVNVIEDKRKFDIMEFVLRLVEAQATYFQQGHEELNRLAQYRKELGTQLHNLVLNSARQKRDMEQRHVLLKQKELGGEEPEPSLKEGPSGLVMEGHLFKRASNAFKTWSRRWFTIQNNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCFLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQVSGYHAPGSAATLACGGAARGRESGGVGQVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPPIRPHSGIVRSKSECPSDDMGSLHPGALLFQAAGHPPSLPTMADALAHGADVNWVNVGQGNATPLIRATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDTEGRDPLTIAMETTNADIVTLLRLAKMREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRRSHDLHTL
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GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
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MKVTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCLANKQFMNGIRDLAQYSCKDALVETNLTKFSDTLQEMINYHNILFDQTQRSIKAQLQTFVKEDIKKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLTFFHQGYDLFSELGPYMKDLGAQLDQLAVDAAKEKRDMEQKHSTIQQKDYSGDDTKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKQEKKSSPSTGSLESGSETKEKLLKGESALQRVQCIPGNAACCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDSWEPELLKLMCELGNDVINRIYEAKLEKMGVKKPQPGSQRQEKEMYIKAKYVERKFVEKQPAAAVSPLESRTKVLPQSQEEKRHSAPEKSFLAIEQGAASPRVRSSDSGIQQSVDDSREHLASTISANSLYEPEGEKQESSVFYDSRQLNPGLHLYRAAFEKNLPDMAEALAHGAEVNWVNMEENKATPLIQAVRGGSLVTCEFLLQNGANVNIRDMKGRGPLHHATVLGHTGQVCLFLKRGANQHATDEDGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDEIYQDIFRDFSQMASNNPEKLNRFQQSDSQKP
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GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity). Widely expressed. Highest level in lung.
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MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLSISKFGPGDQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
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GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35.
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MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEAANILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDSPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKLEKMGVKKPQPGQRQEKEAYIRAKYVERKFVDKYSALLSPSEQEKRIISKSCEDQRLSHARASVHTPVKSNDSGIQQCSEDGRESLPSTVSANSLYEPEGERQESSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSDENQATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
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GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity).
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MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCLANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALAKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCVPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIKAKYVERKFVDKYSVSSSPPEQEKKVVSKDSEEKRLSIPKLGPGDQVRTSIQSSVKSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
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GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35.
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MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCAANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEAANILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDSPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGSESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKLEKMGVKKPQPGQRQEKEAYIRAKYVERKFVDKYSTLLSPSEQEKRIISKSCEDQRLSHTRVSVHTPVKSNDSGIQQCSDDGRESLPSTVSANSLYEPEGERQESSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSDENQATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
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GTPase-activating protein for the ADP ribosylation factor family.
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MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKETKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLRPHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLARMAEEMREAEAAPGPPGALAGSPTELQFRRCIQEFISLHLEES
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Involved in aspartate and glutamate uptake. Plays no significant role in the excretion of accumulated glutamate. Disruption of the gene leads to strong reduction of aspartate uptake, but only marginally affects glutamate uptake. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) (TC 2.A.3.7) family.
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MDTKKIRWFTVAFIAFNMVWGMGNVVNNFAQQGITVVTSWLLILALYFIPYALIVGQLCSTFKDSKGGVSSWVENTSTKRLAYYAAWTYWVVHIPYLAQKPQAILIAFGWVGQGNGNLVSQMSMTAVALISLAIFLAFLWLSTKGLNTLKVIGGLAGTAMFVMSLLFIVMAIGAPFIAKDFHIATPDMGNIKTYIPKFDFSYFTTISMLVFAVGGAEKISPYVNQTKNPAKEFPRGMFLLAGMVGICAVLGSIAMGMIFSSGNLPKDLMANGAYAAFQILGQHFGVGNFLMIVYALTNGVGQIAALAFSIDAPLRILLADADPEYVPAWLRKKTNKGTLKNGYTLTGILVSIIILLPLLGIGDMNELVKWLTNLNSVVMPMRYLWVFFAFIMLNRAVKHFQSEYKFIKQKRLAMIAGAWCFLFTLIACVLGMVPKLDYAANPSAWWFQLASNILTPIVLILLGMLLPFIARREQRKATSLDLDTIVTPD
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Plays a role in autotrophic carbon fixation via the 3-hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl-CoA dependent NADPH oxidation and formation of propionyl-CoA. NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH Monomer. Belongs to the zinc-containing alcohol dehydrogenase family.
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MKAVVVKGHKQGYEVREVQDPKPASGEVIIKVRRAALCYRDLLQLQGFYPRMKYPVVLGHEVVGEILEVGEGVTGFSPGDRVISLLYAPDGTCHYCRQGEEAYCHSRLGYSEELDGFFSEMAKVKVTSLVKVPTRASDEGAVMVPCVTGMVYRGLRRANLREGETVLVTGASGGVGIHALQVAKAMGARVVGVTTSEEKASIVGKYADRVIVGSKFSEEAKKEDINVVIDTVGTPTFDESLKSLWMGGRIVQIGNVDPTQSYQLRLGYTILKDIAIIGHASATRRDAEGALKLTAEGKIRPVVAGTVHLEEIDKGYEMLKDKHKVGKVLLTT
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Plays a role in autotrophic carbon fixation via the 3-hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl-CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA. NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH Optimum pH is 6.0 at 65 degrees Celsius. Retains half maximum activity at pH 7.5 at 65 degrees Celsius. Monomer. Belongs to the zinc-containing alcohol dehydrogenase family.
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MKAIVVPGPKQGYKLEEVPDPKPGKDEVIIRVDRAALCYRDLLQLQGYYPRMKYPVILGHEVVGTIEEVGENIKGFEVGDKVISLLYAPDGTCEYCQIGEEAYCHHRLGYSEELDGFFAEKAKIKVTSLVKVPKGTPDEGAVLVPCVTGMIYRGIRRAGGIRKGELVLVTGASGGVGIHAIQVAKALGAKVIGVTTSEEKAKIIKQYADYVIVGTKFSEEAKKIGDVTLVIDTVGTPTFDESLKSLWMGGRIVQIGNVDPSQIYNLRLGYIILKDLKIVGHASATKKDAEDTLKLTQEGKIKPVIAGTVSLENIDEGYKMIKDKNKVGKVLVKP
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Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine Belongs to the alkaline ceramidase family.
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MDSSSISRWFEYESGHAWCESAYKYQTLPYVAEFANTCTNLPIIVLPLVNIMLLRRYLHDVNGGLVFPQLLLTFNGLASTYYHATLNLFGQLVDELSLVWIITVFLVVYIPVMKWFPERFSKRLTVVRWVVLIVTAVVSALCFLEPNLNAIALMLFSIPAAVVIRYEGKQSGIPDIENFPSRILALWGVAFSFWFADRLLCDFWLYLGTPYLHALFHLLAGLAGYTIFIMFSMIDIESRSKTHRYTAAVRYFPDKNGSIFSFPYISLKERSQ
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Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine Belongs to the alkaline ceramidase family.
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MESSSINRWFEYESGHAWCESAYKYQTLPYVAEFANTCTNLPIIVLPLVNIMLLRRYLHDVNGGLIFPQLLLTFNGLASTYYHATLNLFGQLVDELSLVWIITVFLVVYIPVMKWFPEKFSKRLTLVRWVVLIVTALVSGLCFLEPNLNAIALMLFSIPAAVVINYEGKQSGIPDIESFPSRILALWGVAFSFWFADRLLCDFWLYLGTPYLHALFHLLAGLAGYTIFIMFSMIDIESRTKTHKYTAAVRYFPGKNGSIFSFPYISLKERSQ
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Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine Expressed in the central midgut of late embryos. In brain, it is present at the interhemispheric junction and in groups of cells in the central brain. Discrete defect in the ellipsoid body. Belongs to the alkaline ceramidase family.
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MGGMGGGGLLDIYAMAWEHLRPGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIWVLLIVVGLSSMYFHATLSLIGQLLDELAILWVFMAAFSLFYPKRYYPKFVKNDRKTFSWLMLLSAIAATGLSWWKPIVNAFVLMFMSVPTMVMLYTELQRVSDQRVYRLGIRSTTVWAVAVFCWINDRIFCEAWSSINFPYLHGFWHIFIFIAAYTVLVLFAYFYVESELPQRQPLLKYWPKNEFEFGIPFISIRNPGKALRNTI
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Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the SLC33A transporter family. Leiden Open Variation Database (LOVD)
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MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNN
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Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:10570973). Negatively regulates BMP signaling (By similarity). Expressed in all adult tissues examined including brain, heart, kidney, liver and spleen, with maximum expression in liver and kidney. Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development. Belongs to the SLC33A transporter family.
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MSPTISHKDSSRQRRSGMFSHALDMKSGPLPPGGWDDSRRDSVGGEGDREVLLGDAGPGDLPKAPRSYRSELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYFKNFGRRKSWLVPTQYTLGIFMIYLSTQVDRLLGNIDGRTPDVVALTVTFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENREASIVKEETQGITDTYKLLFSIIKMPAVLAFCLLILTSKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLLISKYTAGPQPLNIFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPLYYYIIVLLSYALHQVTLYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAIELCKKLGGSCVTALDGYYVESIICVLIGFGWWFFLGPKFKKLQDEGPSSWKCKRNN
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Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling (By similarity). Expressed in brain at all developmental stages. Detected in hippocampus, hypothalamus, cerebellum, cortex, olfactory bulb, and the ventral and dorsal anterior olfactory nucleus. Belongs to the SLC33A transporter family.
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MSPTISHKDNSRQRRSGMFGHALDMKSGPLPPGGWDDNHQDSVGGEGDREVLLGDVGPGDFPKAKRSYRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYFKNFGRRKSWLVPTQYILGIFMIYLSTQVDRLLGNIDGRTPDVVALTVTFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKETREASVVKEETQGITDTYKLLFSIIKMPAVLAFCLLILTSKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLLISKYTAGPQPLNIFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIIVLLSYALHQVTLYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPEAIELCKKLGGSCVTALDGYYVESIVCVLIGFGWWFFLGPKFKKLQDEGPSSWKCKRTN
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Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity). Belongs to the ATG37 family.
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MEGDSNPLYEQRFNAAVKVIQNLPPNGSFQPSHDMMLKFYSYYKQATQGPCNIPRPGFWDPVGKAKWDAWSSLGEMPKEEAMAAYVDDLKLILESMPVSSEVEELLQVIGPFYELVDEKRKITQVSDLSTGFGNLLSSPPKCVTKSIIRTMEMNGNLEGYPIKTAETLKVKSIDLEDREDDDDEDEEGERDEVEEFKEVEKASQPKKRVSAGRPKGPVSNGSISQHKGLSNGTHGSKSDLNRQESEENTEHMNHDGGIVELNGHLNSEKDKEEDVSSSHHVASDSDSEVYCDSVDQFGGEDGSEIHMNRSLEVLEESHSTPSSTGDIRSQDDELLGREEGVQHGGEDGRGSRGGAQRRELPVKRSDSSVVRRGRGSRSPASGSGSAGPQQGSGGDGERWGADGPMTENLNEQIICALARLQDDMQSVLQRLHTLEALTASQARSLALPSDYLTTPANRNKKKPSWWPFDVSLGTVAFAVVWPFVVQWLIRVYVQRRRRRIN
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Binds medium- and long-chain acyl-CoA esters.
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MILRGMEDSKSAQKRFEAAVKVIRSLPEDGSYDLSDDMLVLFYSYYKQATEGPCNTLKPNSWDPIGKAKWEAWKDLGNMSKDQAMTEYVQEIQLIIETLPVTDRMAELLDALDPFYEIVEDDDDDDDEGVSKAAPLFTGSTNADKDAERDEEVESESKEGNLDDYMELVEKQKDLSSTTGEKGSLLVFNRSEENSISSLTDGTHSSLNTVDDEEELVYDGSDDEMDSDSMDKPATPEKGSGVRSVRLADGSVVGANMQHGGNREPQCGSQDGKPQGLISPVPHPPTLGTVRNDRISACSGRERGCQGDGGQRGETADRMDKQAINTQITTILSELEDNMQDVLRRLTTLEQLTASQAEISPSKTWHSDKPKKRLSWWPLNSSPFTAVLTVLWPFAVHWLVQFYLQRRRRR
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Catalyzes the cyclization of D-sedoheptulose 7-phosphate to 2-epi-5-epi-valiolone. Does not use ido-heptulose 7-phosphate and 3-deoxy-arabino-heptulosonate 7-phosphate. Involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate Divalent metal cation such as Co(2+). Belongs to the sugar phosphate cyclases superfamily. EEVS family.
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MSGVETVGVHADAHRDSWQVRAQKQITYEVRFRDDVFGLDSTDLLEAGADGAGSRRRFVVVDSAVDALYGSRIREYFTHHGIDHSILVMRVGETVKDFDTAGRIVAAMDAFGLARRREPMIVVGGGVLMDVAGLVASLYRRGTPFLRVPTTLVGLIDAGVGAKTGVNFNGHKNRLGTYAPADLTLLDRRFLATLDRRHLSNGLAEMLKIALIKDAELFQLLERHGRVLIEERFQGRTGTGDRAAVRALRAATHGMLEELGPNLWESRLERSVDYGHTFSPTIEMRALPALLHGEAVCVDMALTTVLAYRRGLLDVAQRDRIFAVMTALGLPTWHPLLTPEVLEAALQDTVRHRDGWQRLPLPVGIGGVTFVNDVTAAELQAAALMQHRLAEDALLLRA
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Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
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MGIENESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLIPQPGFWDPIGRYKWEAWNSLGQMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQALNGDAEAAPEPPCLPKEPAPPSLESQPPRDQDSEVFCDSVEQLEPELVGEEQRGALGGENDTRNSPEPPAEKGRLEGPLLGPQELDSWLVGTVRALQDSMRDVQGRLQSLESMPMPPEQMPPPSARPRPLRLSGPTLIFFLLWPFIVQWLFRQFRTQKR
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MSSYLDFEKSIKQIDDDIANARIKGDEHAVEILNKNLEKEVAKVYKNLNEYQRLQLARHPDRPYAIDYIRSFLMDAYEIHGDRAFRDDPAIVCYVGYIGGKKAMVIGEQKGRGTKNKLRRNFGMPHPEGYRKALRVAKLAEKFNLPILFLIDTPGAYPGVGAEERGQSEAIARNLFEFANLKVPTIAVVIGEGGSGGALAIGVADKLAMMKNSVFSVISPEGCAAILWNDPSKQEQATKAMKITADDLKNLKLIDDVIKEPINGAHRDKDGAAKELASYFVSKLEKLEKLSIDELVAKRIDKILSVGAYEE
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MASYLDFEKGIKQIDDDIANAKIRGDEHAVEILRKNLEKEITKTYKNLNEFQRLNLARHPDRPYALDYIRALLKDGYEIHGDRAFRDDPSIVCYIGYIGGKRVIVIAEQKGRGTKYKIMRNFGMPHPEGYRKALRIARLAEKFEIPIIFLIDTPGAYPGVGAEERGQSEAIARNLFEFSELKTRTIAVVIGEGGSGGALAIGVADRLAMMKNSVFSVISPEGCAAILWNDPSKNEAATKAMKITADDLKELQLIDDVIDEPVMGAHRDKEGAIKALGEYILKQLDELEKKDINDVVKNRIEKILSVGAYA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MANYLDFEKSIKQIDDDISSAKIRGDDSAVEILKKNLEKEINKVYKNLSEFQRLQLARHPDRPYSLDYVRALLKNYYEIHGDRVFRDDPSIVCFLGYIADKKIVVIAEQKGRGTKYKLKRNFGMPHPEGYRKALRVAKLAEKFSIPIIFFIDTPGAYPGIGAEERGQSEAIARNLFEFSDIKTPTIAIVIGEGGSGGALAIGVADKLAMLSNSIFSVISPEGCAAILWKDPDKSEAATKALKITAEELKELNLIDDVIKEPKMGAHRDKDAAAKAVGNYIIEKLNELEKIPLDEILRKRKEKILNTGVFEEL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MASYLDFEKNIQQIDEDIINAQIKGDTEAVSILKKNLEKEISKTYKNLSDFQRLQLARHPDRPYALDYIELILNDAHEIHGDRAFRDDPAIVCFMGYLGEKKIIVIGEQKGRGTKDKIARNFGMPHPEGYRKALRVARLAEKFQIPILFLIDTPGAYPGIGAEERGQSEAIARNLYELSDLKIPTIAIVIGEGGSGGALAIGVADRLAMMKNSVFSVISPEGCAAILWNDPAKSEAATKAMKVTADDLKSQGLIDDVIDEPTNGAHRNKEAAAVAIADYVKKSLNELENIDVRELSANRMQKILKLGAYQEA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MASYLDFEKNIQQIDEDIINAQIKGDTEAVSILKKNLEKEISKTYKNLSDFQRLQLARHPDRPYTLDYIELILNDAHEIHGDRAFRDDPAIVCFMGYLGEKKIIVIGEQKGRGTKDKIARNFGMPHPEGYRKALRVARLAEKFQIPILFLIDTPGAYPGIGAEERGQSEAIARNLYELSDLKIPTIAIVIGEGGSGGALAIGVADRLAMMKNSVFSVISPEGCAAILWNDPAKSEAATKAMKVTADDLKSQGLIDDVIDEPTNGAHRNKEAAAVAIADYVKKSLNELENIDVRELSANRMQKILKLGAYQEA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MASYLDFEKNIQQIDEDIINAQIKGDTEAVSILKKNLEKEISKTYKNLSDFQRLQLARHPDRPYALDYIELILNDAHEIHGDRAFRDDPAIVCFMGYLGEKKIIVIGEQKGRGTKDKIARNFGMPHPEGYRKALRVAGLAEKFQIPILFLIDTPGAYPGIGAEERGQSEAIARNLYELSDLKIPTIAIVIGEGGSGGALAIGVADKLAMMKNSVFSVISPEGCAAILWNDPAKSEAATKAMKVTADDLKSQGLIDDVIDEPTNGAHRNKEAAAVAIADYVKKSLNELENIDVRELSANRMQKILKLGAYQEA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MASYLDFEKNIQQIDEDIINAQIKGDTEAVSILKKNLEKEISKTYKNLSDFQRLQLARHPDRPYALDYIELILNDAHEIHGDRAFRDDPAIVCFMGYLGEKKIIVIGEQKGRGTKDKIARNFGMPHPEGYRKALRVARLAEKFQIPILFLIDTPGAYPGIGAEERGQSEAIARNLYELSDLKIPTIAIVIGEGGSGGALAIGVADRLAMMKNSVFSVISPEGCAAILWNDPAKSEAATKVMKVTADDLKSQGLIDDVIDEPTNGAHRNKEAAAVAIADYVKKSLNELENIDVRELSANRMQKILKLGAYQEA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MASYLDFEKNIQQIDEDIINAQIKGDTEAVSILKKNLEKEISKTYKNLSDFQRLQLARHPDRPYALDYIELILNDAHEIHGDRAFRDDPAIVCFMGYLGEKKIIVIGEQKGRGTKDKIARNFGMPHPEGYRKALRVARLAEKFQIPILFLIDTPGAYPGIGAEERGQSEAIARNLYELSDLKIPTIAIVIGEGGSGGALAIGVADKLVMMKNSVFSVISPEGCAAILWNDPAKSEAATKAMKVTADDLKSQGLIDDVIDEPTNGAHRNKEAAAVAIADYVKKSLNELENIDVRELSANRMQKILKLGAYQEA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MASYLDFEKNIQQIDEDLANAKIKGDDEAVKILEKNLEKETQKVYKNLSDYQRLQLARHPDRPYALDYIQAILSDAYEIHGDRAFRDDPAIVCYAGYIGGKKIIVIGEQKGRGTKDKLHRNFGMPHPEGYRKALRVAKMAEKFNIPVLFLVDTPGAYPGVGAEERGQSEAIARNLYELSALKTITIAVVIGEGGSGGALAIGVADKLAMMKNSVFSVISPEGCAAILWNDPSKSEAATKAMKVTADDLKTQGLIDDVIEEPMSGAHRDKENAIKNLSDYVLKAIEELEQYDKRELAALRMQKIFKFGAFAE
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MANFLFEFEKPLVELENKISDLKKFAEEKNIDVSRELELLSAKAQQLAKEIYQNLTPWQRVLLARHPERPNTRDYINYLCDDFIELKGDRRFGDDPAMIGGIGIIENIPVTIVGNLKGKDTKENIMRNFGMAHPEGYRKAIRLFKQAEKFGRPVLTFIDTPGAFCGIGAEERGQFQAIAEAIATLISLKTPVLAVITGEGGSGGALALAAGDKLLMLENAVFSVIAPESFAAILWKDSSRAQEASELLKLTSEHLLEFGLIDGIIPEPLGGAHRNPAETLKAVKEEVVKNLQILKETPVEELLRRRYQRYRYIGSGIVEGGVS
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MAAHYLDFERPIADLESKIEELSKLSETAGPGAFESEIQALRDRAQQMRKEAYAGLDAWQKTMVARHPERPHLKDYIAGLIDEFVELRGDRKFADDQAIVGGLGRFRGVPVVVMGHEKGHDTTTRLKHNFGMARPEGYRKAVRLMDMAERFNLPVITFVDTAGAYPGLGAEERGQAEAIARSTERGLVLGTPMVATIVGEGGSGGAIALAGANKVLILEHSIYSVISPEGAASILWRDGARAKDAAANMKITAQDLIQLKIVDRIVEEPAGGAHSDPDAAIQSVGDAVEDELKALMKLSAAELKKQRAARFYAIGREGLQ
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MAAHYLDFERPIADLESKIEELSRLSETAGPGAFDTEIQALRDRAQELRKEAYANLDAWQKTMVARHPQRPHLRDYVAGLIDEFVELRGDRKFADDQAIVGGLGRFRGQPVVVMGHEKGHDTTTRLKHNFGMARPEGYRKAVRLMDMAERFNLPVITFVDTAGAYPGLGAEERGQAEAIARSTERCLTLGVPMVATIVGEGGSGGAIALAGANRVLILEHSIYSVISPEGAASILWRDGARAKDAATQMRITAQDLIKLGIVDRIVEEPAGGAHSDTEAAIQAVGDAVEDELKAMAAMSPAELKKQRSDRFYAIGRAGLQ
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MAAHYLDFERPIADLESKIEELSRLSETAGPGAFDTEIQALRDRAQELRKEAYANLDAWQKTMVARHPQRPHLRDYVAGLIDEFVELRGDRKFADDQAIVGGLGRFRGQPVVVMGHEKGHDTTTRLKHNFGMARPEGYRKAVRLMDMAERFNLPVITFVDTAGAYPGLGAEERGQAEAIARSTERCLTLGVPMVATIVGEGGSGGAIALAGANRVLILEHSIYSVISPEGAASILWRDGARAKDAATQMRITAQDLIKLGIVDRIVEEPAGGAHSDTEAAIQAVGDAVEDELKAMAAMSPAELKKQRSDRFYAIGRAGLQ
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNLNYLDFEQPIAELEGKIEELQLVGNSSDVNLADEVAKLREKSTKLTETIYSKLTAWDIVKVARHPQRPYASDYISRVFTEFDELHGDRHFGDDKAIIGGVGRLDGKPVMVIGEEKGRSVHEKVMRNFGMPRPEGYRKALRLMEMAERFKLPVLTLIDTPGAYPGIDSEERGISESIAQNLAVMSRLRTPIVCTVIGEGSSGGALAIGVGDHLNMLQYSTYFVISPEGCANIIWKTVAKAPEAAQAMGVTSKVLQDLGIVDETIPEPLGGAHRNVDEMARKLQERLVEQVEQLSREPIDALLERRYQRLMSYGN
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNYLEFEKPLSEIEGKAEELRALARGNREMDVEKEASALDKKAETLLKDLYKDLTPWRKCQVARHPDRPHCKDYIEGLFTEYTPLAGDRNFADDHAIMGGLARFNDNPVVVIGQEKGHDTKTRIERNFGMARPEGYRKAIRLMEMAHRFRLPVITLVDTPGAYPGKGAEERGQAEAIARATQKCLEIGVPLVAVVIGEGGSGGAVALATANRIAMLEHSVYSVISPEGCASILWKDAEKMREAAEALRLTAQDLHKLGVIDRIIKEPLGGAQRGRRETVDAVGKAIEMMLKELVGRKPEWLVKDRRNKFLDMGSKGLAA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNYLEFEKPLSEIEGKAEELRALARGNREMDVEKEASALDKKAETLLKDLYKDLTPWRKCQVARHPDRPHCKDYIEGLFTEYTPLAGDRNFADDHAIMGGLARFNDNPVVVIGQEKGHDTKTRIERNFGMARPEGYRKAIRLMEMAHRFRLPVITLVDTPGAYPGKGAEERGQAEAIARATQKCLEIGVPLVAVVIGEGGSGGAVALATANRIAMLEHSVYSVISPEGCASILWKDAEKMREAAEALRLTAQDLHKLGVIDRIIKEPLGGAQRGRRETVDAVGKAIEMMLKELVGRKPEWLVKDRRNKFLDMGSKGLAA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNYLEFEKPLSEIEGKAEELRALARGNKEMDVEKEAAALDRKAEALLKDLYKDLTPWRKCQVARHPDRPHCKDYIEGLFTEYMPLAGDRNFADDHAIMGGLARFNDNPVVVIGQEKGHDTKTRIERNFGMARPEGYRKAIRLMDLAHRFRLPVVTLVDTPGAYPGKGAEERGQAEAIARATQKCLELGVPLVTVVIGEGGSGGAVALATANRIAMLEHSVYSVISPEGCASILWKDAEKMREAAEALRLTAQDLHKLGVIDRIIKEPLGGAQRGRRETVEAVGKAIEMMLKELVGRKPDWLIKDRRNKFLDMGSKGLAA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MYNYLDFEKPVADLEGKILELKKLSESGEAVDVAEEISRLERRSKDALRDVYRALTPWQKAQVARHPDRPHCMDYVRALFTDFTPLAGDRAYGEDEAVVAGFARFKGQSIAIVGQEKGNDTHSRLKHNFGMARPEGYRKAVRIMDLADRFGIPVVSLVDTAGAYPGIGAEERGQAEAIARSTSKCLSLKVPNISVIIGEGGSGGAIAIATANLVYMLEHSIYSVISPEGAASILWHDSTRAKDAATNMKITAQDLLQLKVIDGIIPEPVGGAHRASDVVIRTTGETIENGFRELAEKVGDFREQRREKFLAIGRSL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MELLPHEKQVVEYEKTIAEFKEKNKKNSLLSSSEIQKLERRLDKLKEKIYADLTPWERVQICRHPSRPRSVNYIEGMCEEFVELCGDRTFRDDPAVVGGLAKIQGQRFMLIGQEKGCDTSSRMHRNFGMLCPEGFRKALRLAKMAEKFGLSIVFLVDTPGAFPGLTAEERGQGWAIANNLFQLARLKTPIIVLVIGEGCSGGALGMAIGDVIAMLEHSYYSVISPEGCASILWKDPKKNSEAAAMLKMHGEDLKQFAIVDVVIKEPVGGAHHNPAAVYRDVRDFILREWLRLKDLSIEDLLEQRYQKFRTIGLYETSSESSPEA
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MSAKVVLDFEKPLFELEAKLHEMRECLRNTTRDQSPADADLLYGDIEALERKVELLRRSIYKNLTRWQKVQLARHPERPYSLDYIYMMTTGFVELAGDRHFSDDKAIIGGFARLEDEAAGFSQSVMMIGHQKGRDTKTNLYRNFGMAQPEGYRKALRLMKLAEKFRKPIITLIDTPGAFPGIEAEERGQAEAIARNLMEMAQLTVPVICVIIGEGASGGAIGLGVGNRILMAENSWYSVISPESCSSILWRSWNFKEQAAEALQPTAEDLLAQGIVDRIVPEPLGGAHTDPDAMGATLKAMLIEELQQLLPKEPQLLVRERIEKFSAMGVWNEV
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MTRQFLEFEQPIEELNQKIEALRMVGSDNEVNLSEEIARLEAKCSELTENIFSRLEPWQIAQMARHPLRPQTTDYIERIFTDFQELHGDRSYSSAPAIIGGMARLNGEPVMVLGHQKGKRTKEKVYRNFGMARPEEYRKALRLMRMAEKFKMPVVTFIDTAGAYPGIGAEERNQSEAIARNLFAMSRIKTPIICIVTGEAGSGGALAIGVGDKIIMLQFSIYSVISPEGCASILWKDASKASEAARAMGITADRIFENELVDMVVPEPLGGAHRDVDEMASRLKRLLTSELQALKKVPLDQLIELRYQKFMAMGACD
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MTRQFLEFEQPIEELNQKIEALRMVGSDNEVNLSEEIARLEAKCSELTENIFSRLEPWQIAQMARHPLRPQTTDYIERIFTDFQELHGDRSYSSAPAIIGGMARLNGEPVMVLGHQKGKRTKEKVYRNFGMARPEEYRKALRLMRMAEKFKMPVVTFIDTAGAYPGIGAEERNQSEAIARNLFAMSRIKTPIVCIVTGEAGSGGALAIGVGDKIIMLQFSIYSVISPEGCASILWKDASKASEAARAMGITADRIFENELVDMVVPEPLGGAHRDVDEMASRLKRLLTSELQALKKVPLDQLIELRYQKFMAMGACD
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MTRQFLEFEQPIEELNQKIEALRMVGSDNEVNLSEEIARLEAKCSELTENIFSRLEPWQIAQMARHPLRPQTTDYIERIFTDFQELHGDRSYSSAPAIIGGMARLNGEPVMVLGHQKGKRTKEKVYRNFGMARPEEYRKALRLMRMAEKFKMPVVTFIDTAGAYPGIGAEERNQSEAIARNLFAMSRIKTPIVCIVTGEAGSGGALAIGVGDKIIMLQFSIYSVISPEGCASILWKDASKASEAARAMGITADRIFENELVDMVVPEPLGGAHRDVDEMASRLKRLLTSELQALKKVPLDQLIELRYQKFMAMGACD
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLEASIYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRTFGDDAAIVGGIATFKGTPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGLGNQIFMLENAVFSVISPEGAAAILWKDASLAKKAAESMRITAGDLYELGITDGIIPEVKGGAHRDLAAQAEEINKTITKSLHALMAFSEEQLIEQRYDKFKKIGVYETL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLESSIYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRAFGDDAAIVGGIATFHGIPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGVGNQIFMLENAVFSVISPEGAAAILWKDASQAKKAAESMRITAGDLFELGITDGIIPEVKGGAHRDLNAQAEEINKTITKSLHALMAFSEEQLIEQRYEKFKKIGVYDTL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLESSIYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRAFGDDAAIVGGIATFHGIPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGVGNQIFMLENAVFSVISPEGAAAILWKDASQAKKAAESMRITAGDLFELGITDGIIPEVKGGAHRDLNAQAEEINKTITKSLHALMAFSEEQLIEQRYEKFKKIGVYDTL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLGKLESSIYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRAFGDDAAIVGGIATFKGVPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGVGNQIFMLENAVFSVISPEGAAAILWKDASQAKKAAESMRITAGDLFELGITDGIIPEVKGGAHRDLNAQAEEINKTITKSLHALMAFSEEQLIEQRYEKFKKIGVYDTL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLESSIYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRTFGDDAAIVGGIATFKGIPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGVGNQIFMLENAVFSVISPEGAAAILWKDASLAKKAAESMRITAGDLFELGITDGIIPEVKGGAHRDLTAQAEEINKTITKSLHALMAFSEEQLIKQRYEKFKKIGVYETI
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLEASVYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRAFGDDAAIVGGVATFNGIPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGVGNQIFMLENAVFSVISPEGAAAILWKDAGQAKKAAESMRITADDLFELGITDGIIPEVKGGAHRDLTAQAAEINKTITKSLHALMAFSEEQLMNQRYEKFKKIGVYEIL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MHILEFEKPIAELEGKIEELRHLSDGGDVNIADEVSKLQAKVDKLLRSTYAKLTPWQKTQVARHPERPHTLAYISTLIEDFTPLAGDRAFAEDEAIIGGLGRFRGRSVMIIGHEKGHDTETRLKHNFGMAKPEGYRKAKRLMEMADHFQVPIITLVDTAGAYPGVDAEARGQAEAIARSIETCLNVRVPLVSVIIGEGGSGGAIALATGNTVLMLEHAIYSVISPEGCASILWRSAENAKDAAEQLRLTAQDLHKLSIIDSVVPEPMGGAHRNPDLMMQTLSMALDSALRDLSGLDGGVLRARRREKFLEMGRAGLS
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MSQQNQTEYLDFELPIAELEAKIESLRSVTDQDSKIDLDDEIKRLQKKTAELTKKTFADLDAWQVSRMARHPNRPYTLDYISRIFTEFEELAGDRAFADDKAIVGGLARLDGRPVMVIGHQKGRSVKEKVLRNFGMPAPEGYRKALRLMQMAERFRLPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSTLTVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSAEKASTAAEVMGLTASRLKELELIDNIVTEPLGGAHRQYDEMAQALKQRILSDLEDLDILDKETLLDRRYQRLMNYGYV
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNLDYLPFEQPIAELEQKIEELRLVGNDNELNISDEISRLEDKKIALTKSLFSNLGAWEVSQLARHPKRPYTLDYIKHVFTDFEEMHGDRHYADDRAIVGGIARLDGRPVMVIGHQKGREVKEKVLRNFGMPRPEGYRKALRLMETAERFNMPIVTLIDTPGAYPGIGAEERGQSEAIAFNLAVMSRLKTPIISTVIGEGGSGGALAIGVCDELMMLQYGTYSVISPEGCASILWKSADRASDAAKAMGITAQRLQELGFVDTIIQEPLGGAHISHEEMAQSLKKNVLAALDRMEALTTEELLARRYNRLMSYGL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNPNYLDFEQPIADLEAKIEELRMVGNDTDINITDEISRLKKKSISLTESIFSDLKSWDIARLARHPRRPYTQDYIDLIFEDFDELHGDRRYADDLSIIGGTARLDNTPVMIIGHQKGREVRDKVKRNFGMPRPEGYRKALRLMEMAERFKMPILTFIDTPGAYPGIGAEERGQSEAIAFNLAVMSRLKTPIISTVIGEGGSGGALAIGVCDQLNMLQYSTYAVISPEGCASILWKSAEYAAQAAEAMGVTADRLKELGVADHVIDEPLGGAHRNPEKMAETLKTSLAQGVAELSRLPLDELVSRRYERLTRYDGGR
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MDLKFLDFEQPIAELEAKIEELRHVGFDNEINISEEISKLEEKSRKLTESVFSSLSAWQISQISRHPQRPHSRDYIDLIFQEFHELHGDRAFADDPAIIGGLARLDGAAVLVIGHQKGRDTKEKIHRNFGMPRPEGYRKALRLMRLAERFRLPIVCLIDTPGAYPGINAEERGQSEAIARNLFEMAQLQTPIVCVVIGEGGSGGALAIGVGDRLLMLQYSTYSVISPEGCASILWKSADKAELAAEAMGITSERLMELGLIDSIVPEPLGGAHRDRERMADNLKTELKRNLEELAALPMEELLAMRYERLMGYGVYEEPAT
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MRSYLDFEKPVAELEAKLEELRALGARDGAVAISDDVSRLESKAAAALAELYATLTPWQKTQVARHPQRPHFVDYCAGLIEEFTPLAGDRSFGEDEAVVGGFGRFRGRPVCVIGQEKGATTEARIRHNFGMARPEGYRKAVRLMELAGRFGLPVLTFVDTAGAYPGIEAEERGQAEAIARSTEACLALGTPNVALVIGEGGSGGAIALATANRVLMLEHAIYSVISPEGAASILWRDAGRAQDAATAMKITAQDLLRLGVIDGIVPEPTGGAHREPEAAIRAAGDALAEALTGLADLDADALREQRAQKFLEIGRRL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MRSYLDFEKPVAELEAKLEELRALGARDGAVAIAEDVARLESKAAAALAELYAALTPWQKTQVARHPQRPHFVDYCDALISEFTPLAGDRSFGEDEAIVGGFGRFRGRPVCVIGQEKGASTEARIRHNFGMARPEGYRKAVRLMDLAGRFGLPVLTFVDTAGAYPGIDAEERGQAEAIARSTEACLALGTPNLALVIGEGGSGGAIALATANRVLMLEHAIYSVISPEGAASILWRDAGRAQDAATAMKITAQDLLRLGVIDAIVPEPTGGAHRDPAAAFRAAEEAIAEGLAGLDGLDAEALRDQRAQKFLEIGRKL
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MKPVFLDFEQPIAELTNKIDELRFVQDESAVDISDEIHRLQKKSNDLTKSIFSKLTPAQISQVSRHPQRPYTLDYIDALFTDFEELHGDRHFADDHAIVGGLARFNGQSVVVVGHQKGRDTKEKIRRNFGMPRPEGYRKALRLMKTAEKFGLPVMTFIDTPGAYPGIGAEERGQSEAIGKNLYELTRLRVPVLCTVIGEGGSGGALAVAVGDYVNMLQYSTYSVISPEGCASILWKTAEKAADAAQALGITADRLQKLDLVDTVIKEPLGGAHRDFGQTMKNVKAVLEKQLHEAQSIPLADLLSRRFDRIMAYGKFSEQ
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MKPVFLDFEQPIAELTNKIDELRFVQDESAVDISDEIHRLQKKSNDLTKSIFSKLTPAQISQVSRHPQRPYTLDYIDALFTDFEELHGDRHFADDHAIVGGLARFNGQSVVVVGHQKGRDTKEKIRRNFGMPRPEGYRKALRLMKTAEKFGLPVMTFIDTPGAYPGIGAEERGQSEAIGKNLYELTRLRVPVLCTVIGEGGSGGALAVAVGDYVNMLQYSTYSVISPEGCASILWKTAEKAADAAQALGITADRLQKLDLVDTVIKEPLGGAHRDFGQTMKNVKAVLEKQLHEAQSIPLADLLSRRFDRIMAYGKFS
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MKPVFLDFEQPIAELTNKIDELRFVQDESAVDISDEIHRLQKKSNDLTKSIFSKLTPAQVSQVSRHPQRPYTLDYIEALFTDFEELHGDRHFADDYAIVGGLARFNGQSVMVVGHQKGRDTKEKIRRNFGMPRPEGYRKALRLMKTAEKFGLPVMTFIDTPGAYPGIGAEERGQSEAIGKNLYELTRLHVPVLCTVIGEGGSGGALAVAVGDYVNMLQYSTYSVISPEGCASILWKTAEKAADAAQALGITADRLQKLDLVDTVIKEPLGGAHRDFGQTMKNVKAVLEKQLHEAQSIPLADLLSRRFDRIMAYGKFSEQ
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MKPVFLDFEQPIAELTNKIDELRFVQDESAVDISDEIHRLQKKSNDLTKSIFSKLTPAQISQVSRHPQRPYTLDYIEALFTDFEELHGDRHFADDYAIVGGLARFNGQSVMVVGHQKGRDTKEKIRRNFGMPRPEGYRKALRLMKTAEKFGLPVMTFIDTPGAYPGIGAEERGQSEAIGKNLYELTRLRVPVLCTVIGEGGSGGALAVAVGDYVNMLQYSTYSVISPEGCASILWKTAEKAADAAQALGITADRLQKLDLVDTVIKEPLGGAHRDFGQTMKNVKAVLEKQLHEAQSIPLADLLSRRFDRIMAYGKFSEQ
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Inhibited by pyrrolidine dione antibiotic moiramide B (CPD1). Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEIGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKHAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGSRAMEAAELMKITSHELLEMDVVDKVISEVGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MTDVSRVLKEARDQGRLTTLDYANLIFDDFMELHGDRHFSDDGAIVGGLAYLAGQPVTVIGIQKGKNLQDNLARNFGQPNPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIAKNLMEMSDLKVPIIAIIIGEGGSGGALALAVADQVWMLENTMYAVLSPEGFASILWKDGSRATEAAELMKITAGELYQMGIVDRIIPEHGYFSSEIVDIIKANLIEQITSLQAKPLDQLLDERYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MTDVARILKEARDQGRMTALDYASLIFDEFMELHGDRQFADDGSIVGGIAYLADQPVTVIGIQKGKNLQDNLARNFGQPHPEGYRKALRLMKQAEKFGRPVITFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADQVWMLENTMYAVLSPEGFASILWKDGSRATEAAELMKITAAELYQMGVIDRIIPERGYFSSEIVEMIKLHLIDEITQLQAKPLEELLDQRYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MTKITRIIKEARDQARLTALDFAQGIFENFVELHGDRSFRDDGAVIGGIGTLNGQPVTVVGIQKGRNLQDNLRRNFGQPHPEGYRKTLRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSNLKVPIIAIIIGEGGSGGALALAVADKVWMLENSMYAVLSPEGFASILWKDGSRAMEAAELMKITSHELLQMEVVDKVIPERGFNNHELLAAVKEEIAAELDSLSQLPLEQLLENRYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MSDVARILKEARDQGRLTALDFAKEIFDDFIELHGDRNFRDDGAVIGGIGRLNGQAVTVVGIQKGKNLQDNLNRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADKVWMLENTIYSILSPEGFATILWKDGSRSEEAAELMKITSGELLNMGIVDKVIPERGYFTSEIIEAIKTAIVDELAELSQLSTEDLLEARYQRFRRY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MSDVARILKEARDQGRLTALDFAKEIFDDFIELHGDRNFRDDGAVIGGIGRLNGQAVTVVGIQKGKNLQDNLNRNFGQPHPEGYRKALRLMKQAEKFGRSVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADKVWMLENTIYSILSPEGFATILWKDGSRSEEAAELMKITSGELLNMGIVDKVIPERGYFTSEIIEAIKTAIVDELAELSQLSTEDLLEARYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MSDVARILKEARDQGRLTALDFAKEIFDDFIELHGDRNFRDDGAVIGGIGRLNGQAVTVVGIQKGKNLQDNLNRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADKVWMLENTIYSILSPEGFATILWKDGSRSEEAAELMKITSGELLNMGIVDKVIPERGYFTSEIIEAIKTAIVDELAELSQLSTEDLLEARYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MTDVARILKEARDQGRMTALDYANQLFDDFMELHGDRHFADDGAVVGGIGYLDDIAVTMVGIQKGSHLQDNLFRNFGQPHPEGYRKALRLMKQAEKFGRPIITFINTAGAYPGVGAEERGQGEAIARNLFEMSDLKVPIIAIIIGEGGSGGALALAVADQVWMLENAIYAVLSPEGFASILWKDGSRATEAAELMKITAKELKRMTVIDRIIPERGYFSSEIVEMIKEHLKTEINQLRSLPLEELLENRYQRFRNF
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEIGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MATYLDFEQKIKIIQEDIISAQVRHDDGLVASLKKNLDKEVSKIFTNLSPFQQLQLARHVDRPYALDYINLLMRDKYEIHGDRHFRDDAAILCYIGYIGEEKVVVIGEQKGRGTKNKIKRNFGMPHPEGYRKALRAAKLAEKFNLPLLMLVDTPGAYPGIGAEERNQSEAIARNLLELSQLNTQSISVVIGEGGSGGALAIGVADRFAMMRYSVFSVISPEGCSAILWNDPAKVESATNAMKITSGDLKELNLIDDIIAEPLIGAHRDRDSAAAAIGEYFLSELKKLRQMSNEQRMEERYKKLTSVGAFSE
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MATYLDFESKIEKIQHEIVSAHAIANLEAVEKYQKELEKEIEKTFGSLSDYQKLQLARHPDRPYSLDYIKLLMDDAYEIHGDRAFRDDPAILCYIGWIGGQKTMLIGEQKGRGVKNKIKRNFGMPNPEGYRKALRAVRLAEKFDIPVLMLIDTPGAYPGLGAEERGQSEAIARNLFEFSATKVPMISIVIGEGGSGGALAIGVADKLAMLRYSVFAVISPEGCSAILWNDPSKVETATKALKITPSDLLEHKLVDDVLDEPLIGAHRDKVTTAEAIKTYFLESVKALRELSLDEMLDQRYKRLTAVGAYSEK
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Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). Belongs to the AccA family.
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MQFYLDFEKPLVELEQKLSELRDYSTDEVDFSGEIQRLEKKAEKLRREIFSNLNRWQVTQLARHVNRPFTLDFVEHVFTDWFEVHGDRNFRDDPALVCGFARLDGQPCAVIGHQKGRDTKEKVYRNFGMPNPEGYRKALRVMQMAEQFGLPIFTFVDTPGAFPGIGAEERGQAEAIARNLREMAALKVPVIVTVTGEGGSGGALAVAVGNRVLMMENAVYSVISPEGCAAILWKDGAKGPVAAEALKLTAGDIQNLGCVIDEVIPEPLGGAHSDHKAAAEQVRICLKKHLDDLKDLSSDELREQRYQKLRAMTMVQE
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